A plant medicine preparation production control method, system and storage medium

Abstract

The present invention discloses a plant medicine preparation production control method, system and storage medium, which relates to the field of production control technology, including obtaining plant raw material information, obtaining plant active ingredient information based on plant medicine preparation requirements, and obtaining plant active ingredient extraction parameter information based on plant ingredient extraction requirements according to the plant active ingredient information and plant raw material information. The present invention classifies plant raw materials by plant state index, thereby ensuring the reliability and stability of plant raw material component extraction, adjusts plant extraction initial parameters by plant medicine initial raw material quality index, improves plant active ingredient extraction efficiency, accurately evaluates plant active ingredient separation state by plant medicine separation difference coefficient, improves predictability and stability of drug efficacy, and realizes monitoring and analysis of plant medicine preparation production process by plant medicine quality index, thereby ensuring product quality and safety.

Description

Technical Field

[0001] The present invention relates to the technical field of production control, and in particular to a plant medicine preparation production control method, system and storage medium. Background Art

[0002] Phytomedicine preparation refers to the use of plants (such as herbs, trees, plant parts) as raw materials, through a series of processing and preparation processes, to make drugs or medicines for medical or health purposes. These preparation processes may include steps such as collection, drying, grinding, extraction, separation, purification, etc., and finally obtain plant extracts with concentrated active ingredients or purified single ingredients. Many medicinal plants contain various chemical components, such as alkaloids, flavonoids, polysaccharides, volatile oils, etc. These components have various physiological effects on the human body, including anti-inflammatory, antioxidant, antimicrobial, anti-tumor and other effects.

[0003] At present, there are still problems in the production control of herbal medicine preparation, such as the inability to set different plant ingredient extraction parameters according to the specific status of plant active ingredients and plant raw materials, the inability to efficiently and stably extract plant active ingredients, the inability to accurately evaluate the herbal medicine raw materials when separating and purifying the extracted mixture, and the inability to accurately evaluate the quality of the prepared herbal medicine products. Summary of the invention

[0004] In order to solve the above-mentioned technical problems, a method, system and storage medium for controlling the preparation and production of herbal medicines are provided. The technical scheme solves the problems raised in the above-mentioned background technology that different plant component extraction parameters cannot be set according to the specific states of plant active ingredients and plant raw materials, and that efficient and stable extraction of plant active ingredients cannot be performed. When the extracted mixture is separated and purified, the herbal medicine raw materials cannot be accurately evaluated, and the quality of the prepared herbal medicine products cannot be accurately evaluated.

[0005] In order to achieve the above purpose, the technical solution adopted by the present invention is:

[0006] A plant medicine preparation production control method, comprising:

[0007] Acquiring plant raw material information, wherein the plant raw material information includes plant species information, plant state characteristic information and plant collection information;

[0008] According to the plant raw material information, based on the requirements for the preparation of plant medicines, the plant active ingredient information is obtained, wherein the plant active ingredient information is the plant components required for the preparation of plant medicines in each plant;

[0009] According to the plant active ingredient information and the plant raw material information, based on the plant ingredient extraction requirements, the plant active ingredient extraction parameter information is obtained, wherein the plant active ingredient extraction parameter information includes plant ingredient extraction reagent type information, plant ingredient extraction reagent ratio information and plant ingredient extraction environment information;

[0010] Extracting the plant active ingredients according to the plant active ingredient extraction parameter information to obtain the initial raw material information of the plant medicine, wherein the initial raw material information of the plant medicine is a mixture containing the plant active ingredients;

[0011] According to the initial raw material information of plant medicine, based on the separation and purification of plant active ingredients, obtain the raw material information of plant medicine;

[0012] According to the information of plant medicine raw materials and based on plant medicine preparation, obtain plant medicine products.

[0013] Preferably, the obtaining of plant active ingredient extraction parameter information based on plant active ingredient information and plant raw material information and plant ingredient extraction requirements specifically includes:

[0014] According to the plant raw material information, obtain plant state characteristic information, plant species information and plant collection information;

[0015] According to the plant species information, obtain the plant standard status information corresponding to each plant;

[0016] Obtaining a plant state index according to plant standard state information, plant state characteristic information and plant collection information;

[0017] According to the plant state index, based on the plant state index sorting, a maximum value of the plant state index and a minimum value of the plant state index are obtained;

[0018] Based on the extraction requirements of plant active ingredients, the threshold of plant status index is obtained;

[0019] According to the maximum value of the plant state index, the minimum value of the plant state index and the threshold value of the plant state index, it is judged whether the plant raw material needs to be classified. If the difference between the maximum value of the plant state index and the minimum value of the plant state index is lower than the threshold value of the plant state index, the plant raw material does not need to be classified;

[0020] If the difference between the maximum value of the plant state index and the minimum value of the plant state index is higher than the plant state index threshold, the plant raw material needs to be classified, and the plant raw material classification parameters are obtained according to the maximum value of the plant state index, the minimum value of the plant state index and the plant state index threshold;

[0021] Classify the plant raw materials according to the plant raw material classification parameters and obtain the plant raw material classification information;

[0022] According to the classification information of plant raw materials and the information of plant effective components, the initial parameter information of plant extraction is obtained;

[0023] According to the initial parameter information of plant extraction and the plant state index, the quality index of the initial raw material of the plant medicine is obtained;

[0024] According to the quality index of the initial raw materials of the plant medicine, the initial parameters of the plant extraction are adjusted until the initial parameters of the plant extraction reach the maximum value, and the extraction parameter information of the plant active ingredients is obtained.

[0025] Preferably, the step of obtaining the quality index of the initial raw material of the botanical medicine according to the initial parameter information of the plant extraction and the plant state index specifically includes:

[0026] According to the plant active ingredient information, the water-soluble influence coefficient of the plant active ingredient is obtained;

[0027] Obtain plant state index according to plant standard state information, plant state characteristic information, water-soluble influence coefficient of plant active ingredients and plant collection information;

[0028] According to the initial parameter information of plant extraction and the plant state index, the quality index of the initial raw material of the plant medicine is obtained;

[0029] Among them, the calculation formula for the water-soluble influence coefficient of plant active ingredients is:

[0030]

[0031] In the formula, μ is the water-soluble influence coefficient of the plant active ingredient, C is the moisture content of the plant raw material, α is the water-soluble ratio of the plant active ingredient, and β is the water-soluble stability index of the plant active ingredient;

[0032] The calculation formula of plant status index is:

[0033]

[0034] Where Q is the plant status index, is the standard content of plant active ingredients, ΔC=C0-C, where C0 is the standard moisture content of plant raw materials, A is the size of plant raw materials, A0 is the standard size of plant raw materials, B is the color index of plant raw materials, B0 is the standard color index of plant raw materials, and t is the collection time of plant raw materials;

[0035] The calculation formula for the quality index of the initial raw materials of herbal medicines is:

[0036]

[0037] Where E(τ, T, D) is the quality index of the initial raw material of the plant medicine, τ is the ratio of the plant component extraction reagent to the plant raw material, T is the environmental temperature for plant component extraction, D is the environmental humidity for plant component extraction, σ(T) is the temperature influence coefficient of the plant active ingredient, and Z(τ) is the time coefficient for the extraction of the plant active ingredient.

[0038] Preferably, the step of obtaining the botanical drug raw material information based on the initial raw material information of the botanical drug and separation and purification of the plant active ingredients specifically includes:

[0039] According to the initial raw material information of the plant medicine, based on the separation and purification of the plant's active ingredients, the initial processing information of the plant medicine is obtained;

[0040] According to the initial processing information of the plant medicine, based on the high performance liquid chromatography method, the plant medicine component information is obtained, wherein the plant medicine component information includes the plant medicine component retention time information, the plant medicine component type information and the plant medicine component content information;

[0041] According to the information of plant drug components and the quality index of the initial raw materials of plant drugs, the separation difference coefficient of plant drugs is obtained;

[0042] Based on the requirements of plant drug preparation, the threshold of plant drug separation difference coefficient is obtained;

[0043] According to the plant drug separation difference coefficient and the plant drug separation difference coefficient threshold, it is judged whether the separation of plant active ingredients meets the production standard. If the plant drug separation difference coefficient is higher than the plant drug separation difference coefficient threshold, the separation of plant active ingredients does not meet the production standard. According to the plant drug separation difference coefficient, the separation of plant active ingredients is adjusted;

[0044] If the plant drug separation difference coefficient is lower than the plant drug separation difference coefficient threshold, the separation of the plant active ingredients meets the production standards, and the plant drug raw material information is obtained;

[0045] Among them, the calculation formula of the plant drug separation difference coefficient is:

[0046]

[0047] Where W is the coefficient of difference in separation of plant medicines, N x N is the theoretical plate number of ineffective plant components, y is the theoretical plate number of the plant active ingredient, k x is the balance coefficient of the ineffective components of plants, k y is the balance coefficient of the plant's active ingredients, N i is the theoretical plate number of the ineffective components of the i-th plant, t i is the retention time of the ineffective components of the i-th plant, t y ky is the retention time of the active ingredient of the plant, t0 is the retention time of the phaseless substance, E is the quality index of the initial raw material of the plant medicine, and n is the total number of types of ineffective ingredients of the plant.

[0048] Preferably, the step of obtaining the botanical drug product based on the botanical drug raw material information and the botanical drug preparation specifically includes:

[0049] Obtain plant medicine ingredient information based on plant medicine raw material information;

[0050] Based on the preparation of plant medicines, obtain the demand information of plant medicine ingredients;

[0051] According to the plant drug component information and the plant drug component demand information, obtaining the plant drug component combination information, wherein the plant drug component combination information includes the plant active ingredients required for the preparation of the plant drug;

[0052] Obtain the quality index of herbal medicines according to the combination information of herbal medicine ingredients;

[0053] Based on the preparation standards of herbal medicines, the threshold values ​​of herbal medicine quality index are obtained;

[0054] According to the botanical drug quality index and the botanical drug quality index threshold, determine whether the botanical drug component combination meets the botanical drug preparation requirements; if the botanical drug quality index is lower than the botanical drug quality index threshold, adjust the botanical drug component combination according to the botanical drug quality index;

[0055] If the botanical drug quality index is higher than the botanical drug quality index threshold, the botanical drug product is obtained based on the botanical drug component combination information;

[0056] The calculation formula of the plant drug quality index is:

[0057]

[0058] Where G is the quality index of herbal medicine, t j is the retention time of the jth component of the herbal medicine, t ij is the retention time of the i-th plant ineffective component of the botanical drug raw material of the j-th component of the botanical drug, W(j) is the botanical drug separation difference coefficient of the j-th component of the botanical drug, ω j is the peak width of the jth component of the herbal medicine, ω ij The peak width of the i-th plant ineffective ingredient of the botanical drug raw material which is the j-th ingredient of the botanical drug.

[0059] Furthermore, a plant medicine preparation production control system is proposed, which is used to implement the above-mentioned production control method, including:

[0060] A main control module, wherein the main control module is used to determine whether the plant raw materials need to be classified according to the maximum value of the plant state index, the minimum value of the plant state index and the threshold value of the plant state index, determine whether the separation of plant active ingredients meets the production standard according to the plant drug separation difference coefficient and the plant drug separation difference coefficient threshold value, determine whether the combination of plant drug ingredients meets the requirements of plant drug preparation according to the plant drug quality index and the plant drug quality index threshold value, obtain plant raw material classification parameters according to the maximum value of the plant state index, the minimum value of the plant state index and the plant state index threshold value, classify the plant raw materials according to the plant raw material classification parameters, obtain plant raw material classification information, adjust the plant extraction initial parameters according to the plant drug initial raw material quality index until the plant extraction initial parameters reach the maximum value, obtain plant active ingredient extraction parameter information, adjust the plant active ingredient separation according to the plant drug separation difference coefficient, and adjust the plant drug ingredient combination according to the plant drug quality index;

[0061] An information acquisition module, the information acquisition module is used to acquire plant raw material information, plant species information, plant state characteristic information and plant collection information, and acquire plant drug component information, plant drug component retention time information, plant drug component type information and plant drug component content information based on high performance liquid chromatography according to the initial processing information of the plant drug, and transmit the information to the evaluation module;

[0062] An evaluation module, the evaluation module is used to obtain the water-soluble influence coefficient of the plant active ingredient according to the plant active ingredient information, obtain the plant state index according to the plant standard state information, the plant state characteristic information, the water-soluble influence coefficient of the plant active ingredient and the plant collection information, obtain the plant drug initial raw material quality index according to the plant extraction initial parameter information and the plant state index, obtain the plant drug separation difference coefficient according to the plant drug ingredient information and the plant drug initial raw material quality index, obtain the plant drug ingredient combination information according to the plant drug ingredient information and the plant drug ingredient demand information, and obtain the plant drug quality index according to the plant drug ingredient combination information;

[0063] A display module interacts with the main control module and is used to display the water-soluble influence coefficient of the plant active ingredient, the plant state index, the quality index of the initial raw material of the plant medicine, the plant medicine separation difference coefficient and the plant medicine quality index.

[0064] Optionally, the main control module specifically includes:

[0065] A control unit, the control unit is used to obtain plant raw material classification parameters according to the maximum value of the plant state index, the minimum value of the plant state index and the threshold value of the plant state index, classify the plant raw materials according to the plant raw material classification parameters, obtain plant raw material classification information, adjust the plant extraction initial parameters according to the plant drug initial raw material quality index until the plant extraction initial parameters reach the maximum value, obtain plant active ingredient extraction parameter information, adjust the plant active ingredient separation according to the plant drug separation difference coefficient, and adjust the plant drug component combination according to the plant drug quality index;

[0066] An information receiving unit, which interacts with the information acquisition module and the evaluation unit to receive data and transmit it to the judgment unit;

[0067] A judgment unit is used to judge whether it is necessary to classify the plant raw materials according to the maximum value of the plant state index, the minimum value of the plant state index and the plant state index threshold value, judge whether the separation of plant active ingredients meets the production standards according to the plant drug separation difference coefficient and the plant drug separation difference coefficient threshold value, and judge whether the combination of plant drug ingredients meets the requirements of plant drug preparation according to the plant drug quality index and the plant drug quality index threshold value.

[0068] Optionally, the information acquisition module specifically includes:

[0069] A first acquisition unit, the first acquisition unit is used to acquire plant material information, plant species information, plant state characteristic information and plant collection information;

[0070] The second acquisition unit is used to acquire plant drug component information, plant drug component retention time information, plant drug component type information and plant drug component content information based on high performance liquid chromatography according to the initial processing information of the plant drug, and transmit it to the evaluation module.

[0071] Optionally, the evaluation module specifically includes:

[0072] A plant raw material evaluation unit, the plant raw material evaluation unit is used to obtain the water-soluble influence coefficient of the plant active ingredient according to the plant active ingredient information, obtain the plant state index according to the plant standard state information, the plant state characteristic information, the water-soluble influence coefficient of the plant active ingredient and the plant collection information, and obtain the plant medicine initial raw material quality index according to the plant extraction initial parameter information and the plant state index;

[0073] A component separation evaluation unit, the component separation evaluation unit is used to obtain a plant drug separation difference coefficient based on the plant drug component information and the plant drug initial raw material quality index;

[0074] The botanical drug evaluation unit is used to obtain botanical drug component combination information based on botanical drug component information and botanical drug component demand information, and obtain the botanical drug quality index based on the botanical drug component combination information.

[0075] Furthermore, a computer-readable storage medium is proposed, on which a computer-readable program is stored, and when the computer-readable program is called, the production control method as described above is executed.

[0076] Compared with the prior art, the present invention has the following beneficial effects:

[0077] The present invention proposes a botanical medicine preparation production control method, system and storage medium, which classifies plant raw materials through a plant state index to ensure the reliability and stability of plant raw material component extraction, adjusts the initial parameters of plant extraction through the botanical medicine initial raw material quality index, improves the extraction efficiency of plant effective components, accurately evaluates the separation state of plant effective components through the botanical medicine separation difference coefficient, improves the predictability and stability of drug efficacy, and realizes monitoring and analysis of the botanical medicine preparation production process through the botanical medicine quality index to ensure product quality and safety. BRIEF DESCRIPTION OF THE DRAWINGS

[0078] Figure 1 A flow chart of a plant medicine preparation and production control method proposed by the present invention;

[0079] Figure 2 This is a flow chart for obtaining parameter information for extracting active ingredients from plants in the present invention;

[0080] Figure 3 This is a flow chart for obtaining information on botanical drug raw materials in the present invention;

[0081] Figure 4 A flow chart for obtaining the quality index of the botanical drug in the present invention;

[0082] Figure 5 This is a structural block diagram of a plant medicine preparation production control system proposed by the present invention. DETAILED DESCRIPTION

[0083] The following description is used to disclose the present invention so that those skilled in the art can implement the present invention. The preferred embodiments described below are only examples, and those skilled in the art may think of other obvious variations.

[0084] Reference Figure 1 - Figure 4 As shown, a botanical drug preparation and production control method in an embodiment of the present invention comprises:

[0085] S100: Acquire plant raw material information, wherein the plant raw material information includes plant species information, plant state characteristic information and plant collection information;

[0086] S200: According to the plant raw material information and based on the requirements for preparing the plant medicine, obtaining plant active ingredient information, wherein the plant active ingredient information is the plant ingredients required for preparing the plant medicine in each plant;

[0087] S300: According to the plant active ingredient information and the plant raw material information, based on the plant ingredient extraction requirements, obtaining plant active ingredient extraction parameter information, wherein the plant active ingredient extraction parameter information includes plant ingredient extraction reagent type information, plant ingredient extraction reagent ratio information and plant ingredient extraction environment information;

[0088] Specifically, according to the plant active ingredient information and plant raw material information, based on the plant ingredient extraction requirements, the plant active ingredient extraction parameter information is obtained, including:

[0089] According to the plant raw material information, obtain plant state characteristic information, plant species information and plant collection information;

[0090] According to the plant species information, obtain the plant standard status information corresponding to each plant;

[0091] Obtaining a plant state index according to plant standard state information, plant state characteristic information and plant collection information;

[0092] According to the plant state index, based on the plant state index sorting, a maximum value of the plant state index and a minimum value of the plant state index are obtained;

[0093] Based on the extraction requirements of plant active ingredients, the threshold of plant status index is obtained;

[0094] According to the maximum value of the plant state index, the minimum value of the plant state index and the threshold value of the plant state index, it is judged whether the plant raw material needs to be classified. If the difference between the maximum value of the plant state index and the minimum value of the plant state index is lower than the threshold value of the plant state index, the plant raw material does not need to be classified;

[0095] If the difference between the maximum value of the plant state index and the minimum value of the plant state index is higher than the plant state index threshold, the plant raw material needs to be classified, and the plant raw material classification parameters are obtained according to the maximum value of the plant state index, the minimum value of the plant state index and the plant state index threshold;

[0096] Among them, the classification parameters of plant raw materials are:

[0097]

[0098] In the formula, H is the classification parameter of plant raw materials, Qmax is the maximum value of the plant state index, Q min is the minimum value of the plant state index, L is the threshold value of the plant state index, and H is an integer value upward;

[0099] Classify the plant raw materials according to the plant raw material classification parameters and obtain the plant raw material classification information;

[0100] According to the classification information of plant raw materials and the information of plant effective components, the initial parameter information of plant extraction is obtained;

[0101] According to the initial parameter information of plant extraction and the plant state index, the quality index of the initial raw material of the plant medicine is obtained;

[0102] According to the quality index of the initial raw materials of the plant medicine, the initial parameters of the plant extraction are adjusted until the initial parameters of the plant extraction reach the maximum value, and the extraction parameter information of the plant active ingredients is obtained.

[0103] Specifically, according to the plant extraction initial parameter information and the plant state index, the quality index of the initial raw material of the plant medicine is obtained, which specifically includes:

[0104] According to the plant active ingredient information, the water-soluble influence coefficient of the plant active ingredient is obtained;

[0105] Obtain plant state index according to plant standard state information, plant state characteristic information, water-soluble influence coefficient of plant active ingredients and plant collection information;

[0106] According to the initial parameter information of plant extraction and the plant state index, the quality index of the initial raw material of the plant medicine is obtained;

[0107] Among them, the calculation formula for the water-soluble influence coefficient of plant active ingredients is:

[0108]

[0109] In the formula, μ is the water-soluble influence coefficient of the plant active ingredient, C is the moisture content of the plant raw material, α is the water-soluble ratio of the plant active ingredient, and β is the water-soluble stability index of the plant active ingredient;

[0110] The calculation formula of plant status index is:

[0111]

[0112] Where Q is the plant status index, is the standard content of plant active ingredients, ΔC=C0-C, where C0 is the standard moisture content of plant raw materials, A is the size of plant raw materials, A0 is the standard size of plant raw materials, B is the color index of plant raw materials, B0 is the standard color index of plant raw materials, and t is the collection time of plant raw materials;

[0113] The calculation formula for the quality index of the initial raw materials of herbal medicines is:

[0114]

[0115] Where E(τ, T, D) is the quality index of the initial raw material of the plant medicine, τ is the ratio of the plant component extraction reagent to the plant raw material, T is the environmental temperature for plant component extraction, D is the environmental humidity for plant component extraction, σ(T) is the temperature influence coefficient of the plant active ingredient, and Z(τ) is the time coefficient for the extraction of the plant active ingredient.

[0116] In this scheme, the plant state index is obtained through plant standard state information, plant state characteristic information and plant collection information, and whether the plant raw materials need to be classified is determined according to the maximum value of the plant state index, the minimum value of the plant state index and the threshold value of the plant state index;

[0117] It is understandable that the state of plants can often accurately reflect the specific state of plant active ingredients. By using the maximum value of the plant state index, the minimum value of the plant state index and the threshold value of the plant state index, it is possible to avoid excessive differences in the overall state when processing plant raw materials, resulting in the inability to maximize the extraction of plant active ingredients under the same component extraction parameters, thereby ensuring the reliability and stability of the extraction of plant raw material components.

[0118] In this embodiment, plant raw materials are classified according to plant raw material classification parameters to obtain plant raw material classification information, plant extraction initial parameter information is obtained based on the plant raw material classification information and plant effective ingredient information, and the plant medicine initial raw material quality index is obtained based on the plant extraction initial parameter information and the plant state index. Based on the plant medicine initial raw material quality index, the plant extraction initial parameters are adjusted until the plant extraction initial parameters reach the maximum value, and the plant effective ingredient extraction parameter information is obtained, thereby improving the plant effective ingredient extraction efficiency.

[0119] S400: extracting the plant active ingredients according to the plant active ingredient extraction parameter information to obtain the initial raw material information of the plant medicine, wherein the initial raw material information of the plant medicine is a mixture containing the plant active ingredients;

[0120] S500: obtaining plant medicine raw material information based on the separation and purification of plant active ingredients according to the initial raw material information of the plant medicine;

[0121] Specifically, according to the initial raw material information of the plant medicine, based on the separation and purification of the plant's active ingredients, the plant medicine raw material information is obtained, including:

[0122] According to the initial raw material information of the plant medicine, based on the separation and purification of the plant's active ingredients, the initial processing information of the plant medicine is obtained;

[0123] According to the initial processing information of the plant medicine, based on the high performance liquid chromatography method, the plant medicine component information is obtained, wherein the plant medicine component information includes the plant medicine component retention time information, the plant medicine component type information and the plant medicine component content information;

[0124] According to the information of plant drug components and the quality index of the initial raw materials of plant drugs, the separation difference coefficient of plant drugs is obtained;

[0125] Based on the requirements of plant drug preparation, the threshold of plant drug separation difference coefficient is obtained;

[0126] According to the plant drug separation difference coefficient and the plant drug separation difference coefficient threshold, it is judged whether the separation of plant active ingredients meets the production standard. If the plant drug separation difference coefficient is higher than the plant drug separation difference coefficient threshold, the separation of plant active ingredients does not meet the production standard. According to the plant drug separation difference coefficient, the separation of plant active ingredients is adjusted;

[0127] If the plant drug separation difference coefficient is lower than the plant drug separation difference coefficient threshold, the separation of the plant active ingredients meets the production standards, and the plant drug raw material information is obtained;

[0128] Among them, the calculation formula of the plant drug separation difference coefficient is:

[0129]

[0130] Where W is the coefficient of difference in separation of plant medicines, N x N is the theoretical plate number of ineffective plant components, y is the theoretical plate number of the plant active ingredient, k x is the balance coefficient of the ineffective components of plants, k y is the balance coefficient of the plant's active ingredients, N i is the theoretical plate number of the ineffective components of the i-th plant, t i is the retention time of the ineffective components of the i-th plant, t y k y is the retention time of the active ingredient of the plant, t0 is the retention time of the phaseless substance, E is the quality index of the initial raw material of the plant medicine, and n is the total number of types of ineffective ingredients of the plant.

[0131] In this scheme, the plant drug component information is obtained based on the high performance liquid chromatography method through the initial processing information of the plant drug, and the plant drug separation difference coefficient is obtained according to the plant drug component information and the plant drug initial raw material quality index. According to the plant drug separation difference coefficient and the plant drug separation difference coefficient threshold, it is judged whether the separation of the plant active ingredients meets the production standard. The separation state of the plant active ingredients is accurately evaluated through the plant drug separation difference coefficient, thereby improving the predictability and stability of the efficacy;

[0132] It is understandable that when separating and purifying the initial raw materials of botanical medicines, it is impossible to completely remove impurities in the mixture. The botanical medicine component information is obtained through high performance liquid chromatography, and the plant active ingredients in the botanical medicine raw materials are analyzed through the retention time information of the botanical medicine components. The botanical medicine component information and the quality index of the initial raw materials of the botanical medicine are compared to obtain the botanical medicine separation difference coefficient, thereby ensuring that abnormalities in the separation and purification of the initial raw materials of the botanical medicine are discovered in time, thereby improving product quality.

[0133] S600: Obtain a botanical drug product based on botanical drug preparation according to botanical drug raw material information.

[0134] Specifically, according to the information of botanical drug raw materials and based on botanical drug preparation, botanical drug products are obtained, including:

[0135] Obtain plant medicine ingredient information based on plant medicine raw material information;

[0136] Based on the preparation of plant medicines, obtain the demand information of plant medicine ingredients;

[0137] According to the plant drug component information and the plant drug component demand information, obtaining the plant drug component combination information, wherein the plant drug component combination information includes the plant active ingredients required for the preparation of the plant drug;

[0138] Obtain the quality index of herbal medicines according to the combination information of herbal medicine ingredients;

[0139] Based on the preparation standards of herbal medicines, the threshold values ​​of herbal medicine quality index are obtained;

[0140] According to the botanical drug quality index and the botanical drug quality index threshold, determine whether the botanical drug component combination meets the botanical drug preparation requirements; if the botanical drug quality index is lower than the botanical drug quality index threshold, adjust the botanical drug component combination according to the botanical drug quality index;

[0141] If the botanical drug quality index is higher than the botanical drug quality index threshold, the botanical drug product is obtained based on the botanical drug component combination information;

[0142] The calculation formula of the plant drug quality index is:

[0143]

[0144] Where G is the quality index of herbal medicine, t j is the retention time of the jth component of the herbal medicine, t ijis the retention time of the i-th plant ineffective component of the botanical drug raw material of the j-th component of the botanical drug, W(j) is the botanical drug separation difference coefficient of the j-th component of the botanical drug, ω j is the peak width of the jth component of the herbal medicine, ω ij The peak width of the i-th plant ineffective ingredient of the botanical drug raw material which is the j-th ingredient of the botanical drug.

[0145] In this scheme, plant drug ingredient information is obtained through plant drug raw material information, plant drug ingredient combination information is obtained based on the plant drug ingredient information and plant drug ingredient demand information, and the plant drug quality index is obtained based on the plant drug ingredient combination information. According to the plant drug quality index and the plant drug quality index threshold, it is judged whether the plant drug ingredient combination meets the plant drug preparation requirements. The plant drug quality index is used to monitor and analyze the plant drug preparation production process, thereby ensuring product quality and safety.

[0146] It is understandable that when preparing herbal medicines, it is often necessary to combine multiple plant active ingredients to finally prepare the herbal medicine. However, during the preparation process, the ingredient content of the herbal medicine raw materials containing different plant active ingredients is quite different. If the herbal medicine ingredients are combined only according to the required types of plant active ingredients to prepare the herbal medicine, it is often necessary to further analyze and adjust the mixture to ensure the ratio of different plant active ingredients to avoid affecting the quality of the herbal medicine. In this embodiment, the herbal medicine ingredient combination is adjusted through the herbal medicine quality index to improve the efficiency of herbal medicine preparation.

[0147] Reference Figure 5 As shown, further, in combination with the above-mentioned plant medicine preparation production control method, a plant medicine preparation production control system is proposed, comprising:

[0148] A main control module, wherein the main control module is used to determine whether the plant raw materials need to be classified according to the maximum value of the plant state index, the minimum value of the plant state index and the threshold value of the plant state index, determine whether the separation of plant active ingredients meets the production standard according to the plant drug separation difference coefficient and the plant drug separation difference coefficient threshold value, determine whether the combination of plant drug ingredients meets the requirements of plant drug preparation according to the plant drug quality index and the plant drug quality index threshold value, obtain plant raw material classification parameters according to the maximum value of the plant state index, the minimum value of the plant state index and the plant state index threshold value, classify the plant raw materials according to the plant raw material classification parameters, obtain plant raw material classification information, adjust the plant extraction initial parameters according to the plant drug initial raw material quality index until the plant extraction initial parameters reach the maximum value, obtain plant active ingredient extraction parameter information, adjust the plant active ingredient separation according to the plant drug separation difference coefficient, and adjust the plant drug ingredient combination according to the plant drug quality index;

[0149] An information acquisition module, the information acquisition module is used to acquire plant raw material information, plant species information, plant state characteristic information and plant collection information, and acquire plant drug component information, plant drug component retention time information, plant drug component type information and plant drug component content information based on high performance liquid chromatography according to the initial processing information of the plant drug, and transmit the information to the evaluation module;

[0150] An evaluation module, the evaluation module is used to obtain the water-soluble influence coefficient of the plant active ingredient according to the plant active ingredient information, obtain the plant state index according to the plant standard state information, the plant state characteristic information, the water-soluble influence coefficient of the plant active ingredient and the plant collection information, obtain the plant drug initial raw material quality index according to the plant extraction initial parameter information and the plant state index, obtain the plant drug separation difference coefficient according to the plant drug ingredient information and the plant drug initial raw material quality index, obtain the plant drug ingredient combination information according to the plant drug ingredient information and the plant drug ingredient demand information, and obtain the plant drug quality index according to the plant drug ingredient combination information;

[0151] A display module interacts with the main control module and is used to display the water-soluble influence coefficient of the plant active ingredient, the plant state index, the quality index of the initial raw material of the plant medicine, the plant medicine separation difference coefficient and the plant medicine quality index.

[0152] Main control module, including:

[0153] A control unit, the control unit is used to obtain plant raw material classification parameters according to the maximum value of the plant state index, the minimum value of the plant state index and the threshold value of the plant state index, classify the plant raw materials according to the plant raw material classification parameters, obtain plant raw material classification information, adjust the plant extraction initial parameters according to the plant drug initial raw material quality index until the plant extraction initial parameters reach the maximum value, obtain plant active ingredient extraction parameter information, adjust the plant active ingredient separation according to the plant drug separation difference coefficient, and adjust the plant drug component combination according to the plant drug quality index;

[0154] An information receiving unit, which interacts with the information acquisition module and the evaluation unit to receive data and transmit it to the judgment unit;

[0155] A judgment unit is used to judge whether it is necessary to classify the plant raw materials according to the maximum value of the plant state index, the minimum value of the plant state index and the plant state index threshold value, judge whether the separation of plant active ingredients meets the production standards according to the plant drug separation difference coefficient and the plant drug separation difference coefficient threshold value, and judge whether the combination of plant drug ingredients meets the requirements of plant drug preparation according to the plant drug quality index and the plant drug quality index threshold value.

[0156] Information acquisition module, specifically including:

[0157] A first acquisition unit, the first acquisition unit is used to acquire plant material information, plant species information, plant state characteristic information and plant collection information;

[0158] The second acquisition unit is used to acquire plant drug component information, plant drug component retention time information, plant drug component type information and plant drug component content information based on high performance liquid chromatography according to the initial processing information of the plant drug, and transmit it to the evaluation module.

[0159] Assessment modules include:

[0160] A plant raw material evaluation unit, the plant raw material evaluation unit is used to obtain the water-soluble influence coefficient of the plant active ingredient according to the plant active ingredient information, obtain the plant state index according to the plant standard state information, the plant state characteristic information, the water-soluble influence coefficient of the plant active ingredient and the plant collection information, and obtain the plant medicine initial raw material quality index according to the plant extraction initial parameter information and the plant state index;

[0161] A component separation evaluation unit, the component separation evaluation unit is used to obtain a plant drug separation difference coefficient based on the plant drug component information and the plant drug initial raw material quality index;

[0162] The botanical drug evaluation unit is used to obtain botanical drug component combination information based on botanical drug component information and botanical drug component demand information, and obtain the botanical drug quality index based on the botanical drug component combination information.

[0163] Furthermore, the present solution also proposes a computer-readable storage medium, on which a computer-readable program is stored, and when the computer-readable program is called, the production control method as described above is executed;

[0164] It is understandable that the computer-readable storage medium may be a magnetic medium, such as a floppy disk, a hard disk, or a magnetic tape; an optical medium, such as a DVD; or a semiconductor medium, such as a solid state disk (SSD).

[0165] In summary, the advantages of the present invention are: plant active ingredient information, obtaining the water-soluble influence coefficient of the plant active ingredient, evaluating the water solubility of the required plant active ingredient through the water-soluble influence coefficient of the plant active ingredient, judging whether the plant raw materials need to be classified through the plant state index, ensuring the reliability and stability of the plant raw material component extraction, obtaining the plant medicine initial raw material quality index through the plant extraction initial parameter information and the plant state index, adjusting the plant extraction initial parameters through the plant medicine initial raw material quality index, improving the plant active ingredient extraction efficiency, obtaining the plant medicine separation difference coefficient through the plant medicine component information and the plant medicine initial raw material quality index, accurately evaluating the separation state of the plant active ingredient through the plant medicine separation difference coefficient, improving the predictability and stability of the efficacy, and realizing the monitoring and analysis of the plant medicine preparation production process through the plant medicine quality index, ensuring product quality and safety.

[0166] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The above embodiments and descriptions only describe the principles of the present invention. The present invention may be subject to various changes and improvements without departing from the spirit and scope of the present invention. These changes and improvements fall within the scope of the present invention. The scope of protection claimed by the present invention is defined by the attached claims and their equivalents.

Claims

1. A method for controlling the production of plant medicines, characterized in that: include: Acquiring plant raw material information, wherein the plant raw material information includes plant species information, plant state characteristic information and plant collection information; According to the plant raw material information, based on the requirements for the preparation of plant medicines, the plant active ingredient information is obtained, wherein the plant active ingredient information is the plant ingredients required for the preparation of plant medicines in each plant; According to the plant active ingredient information and the plant raw material information, based on the plant ingredient extraction requirements, the plant active ingredient extraction parameter information is obtained, wherein the plant active ingredient extraction parameter information includes plant ingredient extraction reagent type information, plant ingredient extraction reagent ratio information and plant ingredient extraction environment information; Extracting the plant active ingredients according to the plant active ingredient extraction parameter information to obtain the initial raw material information of the plant medicine, wherein the initial raw material information of the plant medicine is a mixture containing the plant active ingredients; According to the initial raw material information of plant medicine, based on the separation and purification of plant active ingredients, obtain the raw material information of plant medicine; According to the information of plant drug raw materials and based on plant drug preparation, obtain plant drug products; The step of obtaining plant active ingredient extraction parameter information based on plant active ingredient information and plant raw material information and plant ingredient extraction requirements specifically includes: According to the plant raw material information, obtain plant state characteristic information, plant species information and plant collection information; According to the plant species information, obtain the plant standard status information corresponding to each plant; Obtaining a plant state index according to plant standard state information, plant state characteristic information and plant collection information; According to the plant state index, based on the plant state index sorting, a maximum value of the plant state index and a minimum value of the plant state index are obtained; Based on the extraction requirements of plant active ingredients, the threshold of plant status index is obtained; According to the maximum value of the plant state index, the minimum value of the plant state index and the threshold value of the plant state index, it is judged whether the plant raw material needs to be classified. If the difference between the maximum value of the plant state index and the minimum value of the plant state index is lower than the threshold value of the plant state index, the plant raw material does not need to be classified; If the difference between the maximum value of the plant state index and the minimum value of the plant state index is higher than the plant state index threshold, the plant raw material needs to be classified, and the plant raw material classification parameters are obtained according to the maximum value of the plant state index, the minimum value of the plant state index and the plant state index threshold; Classify the plant raw materials according to the plant raw material classification parameters and obtain the plant raw material classification information; According to the classification information of plant raw materials and the information of plant effective components, the initial parameter information of plant extraction is obtained; According to the initial parameter information of plant extraction and the plant state index, the quality index of the initial raw material of the plant medicine is obtained; According to the quality index of the initial raw material of the plant medicine, the initial parameters of the plant extraction are adjusted until the initial parameters of the plant extraction reach the maximum value, and the extraction parameter information of the plant active ingredient is obtained; The method of obtaining the botanical drug raw material information based on the initial raw material information of the botanical drug and the separation and purification of the plant active ingredients specifically includes: According to the initial raw material information of the plant medicine, based on the separation and purification of the plant's active ingredients, the initial processing information of the plant medicine is obtained; According to the initial processing information of the plant medicine, based on the high performance liquid chromatography method, the plant medicine component information is obtained, wherein the plant medicine component information includes the plant medicine component retention time information, the plant medicine component type information and the plant medicine component content information; According to the information of plant drug components and the quality index of the initial raw materials of plant drugs, the separation difference coefficient of plant drugs is obtained; Based on the requirements of plant drug preparation, the threshold of plant drug separation difference coefficient is obtained; According to the plant drug separation difference coefficient and the plant drug separation difference coefficient threshold, it is judged whether the separation of plant active ingredients meets the production standard. If the plant drug separation difference coefficient is higher than the plant drug separation difference coefficient threshold, the separation of plant active ingredients does not meet the production standard. According to the plant drug separation difference coefficient, the separation of plant active ingredients is adjusted; If the plant drug separation difference coefficient is lower than the plant drug separation difference coefficient threshold, the separation of the plant active ingredients meets the production standards, and the plant drug raw material information is obtained; Among them, the calculation formula of the plant drug separation difference coefficient is: Where W is the coefficient of difference in separation of plant medicines, N x N is the theoretical plate number of ineffective plant components, y is the theoretical plate number of the plant active ingredient, k x is the balance coefficient of the ineffective components of plants, k y is the balance coefficient of plant active ingredients, N i is the theoretical plate number of the ineffective components of the i-th plant, t i is the retention time of the ineffective components of the i-th plant, t y k y is the retention time of the active ingredient of the plant, t0 is the retention time of the phaseless substance, E is the quality index of the initial raw material of the plant medicine, and n is the total number of types of ineffective ingredients in the plant The method of obtaining a botanical drug product based on botanical drug raw material information and botanical drug preparation specifically includes: Obtain plant medicine ingredient information based on plant medicine raw material information; Based on the preparation of plant medicines, obtain the demand information of plant medicine ingredients; According to the plant drug component information and the plant drug component demand information, obtaining the plant drug component combination information, wherein the plant drug component combination information includes the plant active ingredients required for the preparation of the plant drug; Obtain the quality index of herbal medicines according to the combination information of herbal medicine ingredients; Based on the preparation standards of herbal medicines, the threshold values ​​of herbal medicine quality index are obtained; According to the botanical drug quality index and the botanical drug quality index threshold, determine whether the botanical drug component combination meets the botanical drug preparation requirements; if the botanical drug quality index is lower than the botanical drug quality index threshold, adjust the botanical drug component combination according to the botanical drug quality index; If the botanical drug quality index is higher than the botanical drug quality index threshold, the botanical drug product is obtained based on the botanical drug component combination information; The calculation formula of the plant drug quality index is: Where G is the quality index of herbal medicine, t j is the retention time of the jth component of the herbal medicine, t ij is the retention time of the i-th plant ineffective component of the botanical drug raw material of the j-th component of the botanical drug, W(j) is the botanical drug separation difference coefficient of the j-th component of the botanical drug, ω j is the peak width of the jth component of the herbal medicine, ω ij The peak width of the i-th plant ineffective ingredient of the botanical drug raw material which is the j-th ingredient of the botanical drug.

2. A plant medicine preparation and production control method according to claim 1, characterized in that: The method of obtaining the quality index of the initial raw material of the botanical medicine according to the initial parameter information of the plant extraction and the plant state index specifically includes: According to the plant active ingredient information, the water-soluble influence coefficient of the plant active ingredient is obtained; Obtain plant state index according to plant standard state information, plant state characteristic information, water-soluble influence coefficient of plant active ingredients and plant collection information; According to the initial parameter information of plant extraction and the plant state index, the quality index of the initial raw material of the plant medicine is obtained; Among them, the calculation formula for the water-soluble influence coefficient of plant active ingredients is: In the formula, μ is the water-soluble influence coefficient of the plant active ingredient, C is the moisture content of the plant raw material, α is the water-soluble ratio of the plant active ingredient, and β is the water-soluble stability index of the plant active ingredient; The calculation formula of plant status index is: Where Q is the plant status index, is the standard content of plant active ingredients, ΔC=C0-C, where C0 is the standard moisture content of plant raw materials, A is the size of plant raw materials, A0 is the standard size of plant raw materials, B is the color index of plant raw materials, B0 is the standard color index of plant raw materials, and t is the collection time of plant raw materials; The calculation formula for the quality index of the initial raw materials of herbal medicines is: Where E(τ, T, D) is the quality index of the initial raw material of the plant medicine, τ is the ratio of the plant component extraction reagent to the plant raw material, T is the environmental temperature for plant component extraction, D is the environmental humidity for plant component extraction, σ(T) is the temperature influence coefficient of the plant active ingredient, and Z(τ) is the time coefficient for the extraction of the plant active ingredient.

3. A plant medicine preparation production control system, used to implement the production control method according to any one of claims 1-2, characterized in that: include: A main control module, wherein the main control module is used to determine whether the plant raw materials need to be classified according to the maximum value of the plant state index, the minimum value of the plant state index and the threshold value of the plant state index, determine whether the separation of plant active ingredients meets the production standard according to the plant drug separation difference coefficient and the plant drug separation difference coefficient threshold value, determine whether the combination of plant drug ingredients meets the requirements of plant drug preparation according to the plant drug quality index and the plant drug quality index threshold value, obtain plant raw material classification parameters according to the maximum value of the plant state index, the minimum value of the plant state index and the plant state index threshold value, classify the plant raw materials according to the plant raw material classification parameters, obtain plant raw material classification information, adjust the plant extraction initial parameters according to the plant drug initial raw material quality index until the plant extraction initial parameters reach the maximum value, obtain plant active ingredient extraction parameter information, adjust the plant active ingredient separation according to the plant drug separation difference coefficient, and adjust the plant drug ingredient combination according to the plant drug quality index; An information acquisition module, the information acquisition module is used to acquire plant raw material information, plant species information, plant state characteristic information and plant collection information, and acquire plant drug component information, plant drug component retention time information, plant drug component type information and plant drug component content information based on high performance liquid chromatography according to the initial processing information of the plant drug, and transmit the information to the evaluation module; An evaluation module, the evaluation module is used to obtain the water-soluble influence coefficient of the plant active ingredient according to the plant active ingredient information, obtain the plant state index according to the plant standard state information, the plant state characteristic information, the water-soluble influence coefficient of the plant active ingredient and the plant collection information, obtain the plant drug initial raw material quality index according to the plant extraction initial parameter information and the plant state index, obtain the plant drug separation difference coefficient according to the plant drug ingredient information and the plant drug initial raw material quality index, obtain the plant drug ingredient combination information according to the plant drug ingredient information and the plant drug ingredient demand information, and obtain the plant drug quality index according to the plant drug ingredient combination information; A display module interacts with the main control module and is used to display the water-soluble influence coefficient of the plant active ingredient, the plant state index, the quality index of the initial raw material of the plant medicine, the plant medicine separation difference coefficient and the plant medicine quality index.

4. A plant medicine preparation and production control system according to claim 3, characterized in that: The main control module specifically includes: A control unit, the control unit is used to obtain plant raw material classification parameters according to the maximum value of the plant state index, the minimum value of the plant state index and the threshold value of the plant state index, classify the plant raw materials according to the plant raw material classification parameters, obtain plant raw material classification information, adjust the plant extraction initial parameters according to the plant drug initial raw material quality index until the plant extraction initial parameters reach the maximum value, obtain plant active ingredient extraction parameter information, adjust the plant active ingredient separation according to the plant drug separation difference coefficient, and adjust the plant drug component combination according to the plant drug quality index; An information receiving unit, which interacts with the information acquisition module and the evaluation unit to receive data and transmit it to the judgment unit; A judgment unit is used to judge whether it is necessary to classify the plant raw materials according to the maximum value of the plant state index, the minimum value of the plant state index and the plant state index threshold value, judge whether the separation of plant active ingredients meets the production standards according to the plant drug separation difference coefficient and the plant drug separation difference coefficient threshold value, and judge whether the combination of plant drug ingredients meets the requirements of plant drug preparation according to the plant drug quality index and the plant drug quality index threshold value.

5. A plant medicine preparation and production control system according to claim 3, characterized in that: The information acquisition module specifically includes: A first acquisition unit, the first acquisition unit is used to acquire plant material information, plant species information, plant state characteristic information and plant collection information; The second acquisition unit is used to acquire plant drug component information, plant drug component retention time information, plant drug component type information and plant drug component content information based on high performance liquid chromatography according to the initial processing information of the plant drug, and transmit it to the evaluation module.

6. A plant medicine preparation production control system according to claim 3, characterized in that: The evaluation module specifically includes: A plant raw material evaluation unit, the plant raw material evaluation unit is used to obtain the water-soluble influence coefficient of the plant active ingredient according to the plant active ingredient information, obtain the plant state index according to the plant standard state information, the plant state characteristic information, the water-soluble influence coefficient of the plant active ingredient and the plant collection information, and obtain the plant medicine initial raw material quality index according to the plant extraction initial parameter information and the plant state index; A component separation evaluation unit, the component separation evaluation unit is used to obtain a plant drug separation difference coefficient based on the plant drug component information and the plant drug initial raw material quality index; The botanical drug evaluation unit is used to obtain botanical drug component combination information based on botanical drug component information and botanical drug component demand information, and obtain the botanical drug quality index based on the botanical drug component combination information.

7. A computer-readable storage medium having a computer-readable program stored thereon, characterized in that: When the computer-readable program is called, it executes the production control method according to any one of claims 1-2.

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