Whitening skin care product containing smart microcapsules and preparation method thereof

Abstract

The present invention provides a whitening skincare product containing smart microcapsules and a preparation method thereof, belonging to the field of whitening skincare products. The whitening skincare product containing the smart microcapsules primarily comprises the following ingredients in parts by weight: 25-30 parts by weight of Galla chinensis, 5-10 parts by weight of a calyx leaf extract, 1-2 parts by weight of sodium hyaluronate, 1-5 parts by weight of ectoine, 10-20 parts by weight of smart microcapsules, and an appropriate amount of solvent. The whitening skincare product containing the smart microcapsules can achieve long-lasting whitening effects through the use of the smart microcapsules.

Description

Technical Field

[0001] The present invention relates to a whitening skin care product containing smart microcapsules and a preparation method thereof, in particular to a whitening skin care product containing smart microcapsules, which can achieve long-lasting whitening skin care effects through the smart microcapsules. Background Art

[0002] With economic development and the gradual improvement of living standards in my country, women's desire for youthful beauty is also increasing. An ancient Chinese saying, "A white complexion hides a hundred flaws," vividly reflects this desire. Even, fair skin is a form of beauty sought after by Chinese people, especially women.

[0003] In the pursuit of fair skin, different people encounter various problems and employ different methods to solve them. For example, some people exfoliate to promote rapid skin renewal, thereby achieving fair and even skin. This method accelerates keratin metabolism, making it faster than the rate of melanin metabolism and transfer to the stratum corneum. While it can quickly and evenly brighten the skin, it also thins the stratum corneum. Long-term use can damage the skin barrier and cause sensitivity. However, this method is more damaging to the skin and is also costly.

[0004] For the majority of consumers who love beauty and are cautious, whitening skin care products are still the first choice for whitening and skin care. Whitening skin care products are a type of cosmetics that whitens the skin. They can generally be divided into four categories: (1) those with white or light pigments, which can cover dark skin after use, producing a physical whitening effect; (2) those containing (water) fruit acid, which can accelerate the exfoliation of the stratum corneum of aged skin, that is, using skin peeling to whiten the skin; (3) those containing sunscreens to reduce the darkening caused by ultraviolet radiation on the skin; (4) those containing substances that inhibit tyrosinase activity and block the production of melanin. Strictly speaking, only the fourth category can be considered true whitening skin care products.

[0005] On the other hand, existing whitening skincare products offer very limited protection. Their effectiveness typically disappears within one to two hours of application, leaving only a film on the surface. Because existing skincare products largely follow the R&D practices of a few major international companies, they often use ingredients containing various chemicals. While China has various performance testing and ingredient safety requirements, some ingredients can still adversely affect the skin if left unwashed for extended periods, potentially leading to serious skin diseases in susceptible individuals.

[0006] Gallnut, also known as Manila clam, was first mentioned in the Kaibao Materia Medica and has a long history of medicinal use. It is cold in nature, bitter, sour, and astringent, and is non-toxic. Its primary benefits include astringing the lungs, astringing the intestines, stopping sweating, stopping bleeding, detoxifying, and healing wounds. It has antibacterial and antifungal properties, and can soften scars. It is used for eczema, tinea manuum, pedis, neurodermatitis, and keloids. The Jiangsu Traditional Chinese Medicine Miscellanea also records that gallnut has skin-tonifying and detoxifying properties, treats chapped hands and feet, regulates the skin, enhances beauty, and promotes longevity. The Compendium of Materia Medica states that Schisandra chinensis "enhances the human body," and its nutrient-rich properties contribute to a rosy complexion and fair skin.

[0007] Microencapsulation technology involves encapsulating dispersed solid particles, liquid droplets, or even gases into tiny, semipermeable or sealed capsules using natural or synthetic polymer materials. The resulting tiny particles are called microcapsules, and the material encapsulated within them becomes the core material or capsule core. These capsules are typically single-layer structures, but can also be multi-layered. Microcapsules typically have a particle size of 1-1000 microns, with microcapsules smaller than 1 micron being called nanocapsules. Currently, microencapsulation technology is used in the chemical industry, construction, medicine, and other fields. However, its use in skin care products has not yet been seen, and microcapsules also face significant technical hurdles in achieving skin compatibility.

[0008] During the research process, the inventor intended to use improved microcapsule technology and beneficial whitening skin care components to obtain a skin care product that can achieve a mild and long-lasting whitening skin care effect, so as to meet the actual needs of the Chinese people for high-end whitening skin care products. Summary of the Invention

[0009] The present invention provides a whitening skin care product containing smart microcapsules and a preparation method thereof, aiming to provide a whitening skin care product that can achieve long-lasting whitening skin care effects, reduce the use of chemical preparations in skin care products, reduce skin irritation, improve the skin-friendliness of skin care products, and prolong the whitening effect.

[0010] The purpose of the present invention is to overcome the shortcomings of the prior art and provide a whitening skin care product containing smart microcapsules. To achieve this technical purpose, the technical solution adopted by the present invention is:

[0011] A whitening skin care product containing smart microcapsules is characterized by mainly comprising the following ingredients in percentage by weight: 25-30 parts by weight of gallnut, 5-10 parts by weight of calyx leaf extract, 1-2 parts by weight of sodium hyaluronate, 1-5 parts by weight of ectoine, 10-20 parts by weight of smart microcapsules, and an appropriate amount of solvent.

[0012] Preferably, the smart microcapsules are hydrogel smart microcapsules.

[0013] Preferably, the raw materials for preparing the hydrogel smart microcapsules include polyvinyl alcohol, microcapsules, and collagen.

[0014] Preferably, the mass ratio of the polyvinyl alcohol, microcapsules and collagen is 1-10:1-10:0.1-2.

[0015] Preferably, the microcapsule comprises a core material and a wall material, wherein the wall material is selected from carbohydrates, colloidal substances, proteins, and cellulose; and the core material is selected from lauric acid or polyethylene glycol.

[0016] Preferably, the carbohydrate is selected from maltodextrin, cyclodextrin, corn starch, monosaccharide or polysaccharide; the colloidal substance is selected from gum arabic, alginate or locust gum; the protein is selected from soy protein or gelatin; and the cellulose is selected from methylcellulose, ethylcellulose or carboxymethylcellulose.

[0017] Preferably, the calyx leaf extract is an extract obtained by extracting, alkalizing and purifying the calyx leaves.

[0018] Preferably, the solvent is distilled water or deionized water.

[0019] Preferably, the method for preparing the smart microcapsules comprises the following steps:

[0020] 1) dispersing the microcapsules and collagen in a solvent to prepare a dispersion;

[0021] 2) dissolving polyvinyl alcohol in a solvent to prepare a polyvinyl alcohol solution;

[0022] 3) uniformly mixing the dispersion and the polyvinyl alcohol solution, and allowing to stand for defoaming to obtain a mixed solution;

[0023] 4) The mixed solution of step 3) is frozen and then immersed in water to obtain smart microcapsules.

[0024] On the other hand, the present invention also provides a method for preparing a whitening skin care product containing smart microcapsules, characterized in that the method comprises the following steps:

[0025] a) mixing 25-30 parts by weight of gallnut, 5-10 parts by weight of calyx leaf extract, 1-2 parts by weight of sodium hyaluronate, 1-5 parts by weight of ectoine, and an appropriate amount of solvent, and dispersing the mixture at high speed by ultrasonication to obtain a mixture;

[0026] b) mixing 10-20 parts by weight of the smart microcapsules with the mixture of step a), and dispersing the mixture by low-speed mechanical stirring to obtain a skin care product.

[0027] Preferably, the method for preparing the smart microcapsules comprises the following steps:

[0028] 1) dispersing the microcapsules and collagen in a solvent to prepare a dispersion;

[0029] 2) dissolving polyvinyl alcohol in a solvent to prepare a polyvinyl alcohol solution;

[0030] 3) uniformly mixing the dispersion and the polyvinyl alcohol solution, and allowing to stand for defoaming to obtain a mixed solution;

[0031] 4) The mixed solution of step 3) is frozen and then immersed in water to obtain smart microcapsules.

[0032] Compared with the prior art, the present invention has the following advantages and beneficial effects.

[0033] (1) The whitening skin care product of the present invention does not contain any oily antioxidant ingredients such as grease, wax, hydrocarbons, preservatives, mildew inhibitors, moisturizers, surfactants, pH regulators such as acids or alkalis, pigments and other chemical agents, and has very little irritation to human skin, thereby significantly improving the skin-friendliness of the skin care product.

[0034] (2) The present invention creatively introduces smart microcapsules. Due to the special structure of the microcapsules, whitening and skin care components such as gallnut, calyx leaf extract, sodium hyaluronate, and ectoine can be embedded in the microcapsules and gradually released to achieve a long-term whitening and skin care effect.

[0035] (3) The present invention adopts specific microcapsule core materials and wall materials, and combines them with whitening skin care components such as gallnut, calyx leaf extract, sodium hyaluronate, and ectoine, thereby increasing the encapsulation capacity of the microcapsules for the whitening components and prolonging the release time.

[0036] (4) The present invention has made a breakthrough discovery that the use of the extract of the calyx leaves in combination with ectoine can improve the whitening effect of skin care products.

[0037] (5) The smart microcapsules of the present invention use collagen components with good biocompatibility and bioactivity. Even if the whitening and skin care components such as gallnut, calyx leaf extract, sodium hyaluronate, and ectoine are lost too quickly due to external factors, the smart microcapsules will still slowly release collagen to maintain a long-term whitening and skin care effect. DETAILED DESCRIPTION

[0038] The following embodiments are merely examples of the present invention and do not constitute any limitation to the scope of implementation.

[0039] Example 1

[0040] A method for preparing a whitening skin care product containing smart microcapsules, comprising:

[0041] a) mixing 25 parts by weight of gallnut, 10 parts by weight of calyx leaf extract, 1.5 parts by weight of sodium hyaluronate, 3 parts by weight of ectoine, and an appropriate amount of solvent, and dispersing the mixture at high speed by ultrasonication to obtain a mixture;

[0042] b) mixing 10 parts by weight of the smart microcapsules with the mixture obtained in step a), and dispersing the mixture by low-speed mechanical stirring to obtain a skin care product.

[0043] The preparation method of the smart microcapsule comprises the following steps:

[0044] 1) dispersing the microcapsules and collagen in a solvent to prepare a dispersion;

[0045] 2) dissolving polyvinyl alcohol in a solvent to prepare a polyvinyl alcohol solution;

[0046] 3) uniformly mixing the dispersion and the polyvinyl alcohol solution, and allowing to stand for defoaming to obtain a mixed solution;

[0047] 4) The mixed solution of step 3) is frozen and then immersed in water to obtain smart microcapsules.

[0048] Example 2

[0049] A method for preparing a whitening skin care product containing smart microcapsules, comprising:

[0050] a) mixing 30 parts by weight of Galla chinensis, 5 parts by weight of a calyx leaf extract, 1 part by weight of sodium hyaluronate, 1 part by weight of Ectoin, and an appropriate amount of a solvent, and dispersing the mixture at high speed by ultrasonication to obtain a mixture;

[0051] b) mixing 20 parts by weight of the smart microcapsules with the mixture obtained in step a), and dispersing the mixture by low-speed mechanical stirring to obtain a skin care product.

[0052] The preparation method of the smart microcapsules is the same as that in Example 1.

[0053] Example 3

[0054] A method for preparing a whitening skin care product containing smart microcapsules, comprising:

[0055] a) mixing 28 parts by weight of Galla chinensis, 8 parts by weight of a calyx leaf extract, 2 parts by weight of sodium hyaluronate, 5 parts by weight of Ectoin, and an appropriate amount of a solvent, and dispersing the mixture at high speed by ultrasonication to obtain a mixture;

[0056] b) 15 parts by weight of the smart microcapsules were mixed with the mixture obtained in step a), and the mixture was dispersed by low-speed mechanical stirring to obtain a skin care product.

[0057] The preparation method of the smart microcapsules is the same as that in Example 1.

[0058] Example 4

[0059] A method for preparing a whitening skin care product containing smart microcapsules, comprising:

[0060] a) mixing 25 parts by weight of gallnut, 5 parts by weight of calyx leaf extract, 1 part by weight of sodium hyaluronate, 5 parts by weight of ectoine, and an appropriate amount of solvent, and dispersing the mixture at high speed by ultrasonication to obtain a mixture;

[0061] b) 15 parts by weight of the smart microcapsules were mixed with the mixture obtained in step a), and the mixture was dispersed by low-speed mechanical stirring to obtain a skin care product.

[0062] The preparation method of the smart microcapsules is the same as that in Example 1.

[0063] Example 5

[0064] A method for preparing a whitening skin care product containing smart microcapsules, comprising:

[0065] a) mixing 25 parts by weight of gallnut, 8 parts by weight of calyx leaf extract, 1 part by weight of sodium hyaluronate, 2 parts by weight of ectoine, and an appropriate amount of solvent, and dispersing the mixture at high speed by ultrasonication to obtain a mixture;

[0066] b) 15 parts by weight of the smart microcapsules were mixed with the mixture obtained in step a), and the mixture was dispersed by low-speed mechanical stirring to obtain a skin care product.

[0067] The preparation method of the smart microcapsules is the same as that in Example 1.

[0068] Example 6

[0069] A method for preparing a whitening skin care product containing smart microcapsules, comprising:

[0070] a) mixing 25 parts by weight of Galla chinensis, 10 parts by weight of a calyx leaf extract, 1 part by weight of sodium hyaluronate, 1 part by weight of Ectoin, and an appropriate amount of a solvent, and dispersing the mixture at high speed by ultrasonication to obtain a mixture;

[0071] b) 15 parts by weight of the smart microcapsules were mixed with the mixture obtained in step a), and the mixture was dispersed by low-speed mechanical stirring to obtain a skin care product.

[0072] The preparation method of the smart microcapsules is the same as that in Example 1.

[0073] Example 7

[0074] A method for preparing a whitening skin care product containing smart microcapsules, comprising:

[0075] a) mixing 25 parts by weight of gallnut, 1 part by weight of sodium hyaluronate, 5 parts by weight of ectoine, and an appropriate amount of solvent, and dispersing the mixture at high speed by ultrasonication to obtain a mixture;

[0076] b) 15 parts by weight of the smart microcapsules were mixed with the mixture obtained in step a), and the mixture was dispersed by low-speed mechanical stirring to obtain a skin care product.

[0077] The preparation method of the smart microcapsules is the same as that in Example 1.

[0078] Example 8

[0079] A method for preparing a whitening skin care product containing smart microcapsules, comprising:

[0080] a) mixing 25 parts by weight of Galla chinensis, 5 parts by weight of a calyx leaf extract, 1 part by weight of sodium hyaluronate, and an appropriate amount of a solvent, and dispersing the mixture by ultrasonic high-speed dispersing to obtain a mixture;

[0081] b) 15 parts by weight of the smart microcapsules were mixed with the mixture obtained in step a), and the mixture was dispersed by low-speed mechanical stirring to obtain a skin care product.

[0082] The preparation method of the smart microcapsules is the same as that in Example 1.

[0083] Example 9

[0084] A method for preparing a whitening skin care product containing smart microcapsules, comprising:

[0085] a) mixing 28 parts by weight of Galla chinensis, 8 parts by weight of a calyx leaf extract, 2 parts by weight of sodium hyaluronate, 5 parts by weight of Ectoin, and an appropriate amount of a solvent, and dispersing the mixture at high speed by ultrasonication to obtain a mixture;

[0086] b) The mixtures prepared in step a) are mixed and dispersed by low-speed mechanical stirring to obtain a skin care product.

[0087] The preparation method of the smart microcapsules is the same as that in Example 1.

[0088] Example 10

[0089] A method for preparing a whitening skin care product containing smart microcapsules, comprising:

[0090] a) mixing 28 parts by weight of Chinese gallnut, 2 parts by weight of sodium hyaluronate, and an appropriate amount of solvent, and dispersing the mixture by ultrasonic high-speed dispersion to obtain a mixture;

[0091] b) 15 parts by weight of the smart microcapsules were mixed with the mixture obtained in step a), and the mixture was dispersed by low-speed mechanical stirring to obtain a skin care product.

[0092] The preparation method of the smart microcapsules is the same as that in Example 1.

[0093] Comparative Example 1

[0094] A foreign whitening skin care product K on the market

[0095] Comparative Example 2

[0096] A foreign whitening skin care product S on the market

[0097] Table 1: List of main ingredients of Examples and Comparative Examples (parts by weight)

[0098]

[0099] The performance test adopts the "in vitro zebrafish embryo melanin production inhibition test". The specific method refers to the whitening efficacy evaluation model in the "Study on the Skin Care Efficacy of Brown Rice Fermentation Filtrate-Zebrafish Experiment". The experiment of this whitening efficacy evaluation model refers to T / SHRH036-2021 Cosmetic Melanin Inhibition Test-Zebrafish Embryo Test Method.

[0100] Test process: The experiment refers to the T / SHRH036-2021 Cosmetic Melanin Inhibition - Zebrafish Embryo Test Method. 96 8-hour-old zebrafish embryos were placed in a 96-well plate, with one fish embryo per well. They were randomly divided into four groups: a blank control group, a 100% melanin inhibition group, a positive control group, and a sample treatment group. 0.2 mL of fish embryo culture medium, 0.2 mL of 1.5 mg / mL phenylthiourea solution (completely inhibits melanin production and serves as a benchmark for 100% whitening effect), 0.2 mL of 2.5 g / L kojic acid solution, and 0.2 mL of 5 g / L sample solution were added to the plates. After incubation in a 28±1°C incubator for 48 hours, the fish embryos were photographed under a microscope. Image J was used to measure the transmittance of the fish embryos as the pigment signal intensity and perform statistical analysis.

[0101] The formula for calculating the zebrafish melanin inhibition rate is:

[0102] Inhibition rate = (CT) / (CP)×100%

[0103] Where: T—average melanin signal intensity of fish embryos in sample treatment group;

[0104] C—average melanin signal intensity of fish embryos in the blank control group;

[0105] P—mean value of melanin signal intensity in the 100% melanin inhibition group;

[0106] The test results are shown in Table 2. Phenylthiourea was used as a positive control. Taking the melanin inhibition rate of the positive control as 100%, the melanin inhibition rates of the zebrafish embryos of Examples 1-10 and Comparative Examples 1-2 are shown in Table 2 below:

[0107] Table 2:

[0108] Experimental group Inhibition rate Example 1 67％ Example 2 66％ Example 3 71％ Example 4 68％ Example 5 65％ Example 6 64％ Example 7 23％ Example 8 25％ Example 9 16％ Example 10 18％ Comparative Example 1 17％ Comparative Example 2 15％

[0109] The above test results show that Example 3 has the most significant inhibitory effect. The melanin inhibition rate of a commercially available foreign whitening skincare product, K / S, is at a standard level. For this skincare product, even without the calyx ulina leaf extract, ectoine, and smart microcapsules, the melanin inhibition rate is also at a standard level. When the skincare product with this formula is used in its entirety, the melanin inhibition rate is significantly improved. This demonstrates that the combined use of calyx ulina leaf extract, ectoine, and smart microcapsules significantly improves the melanin inhibition rate, demonstrating a synergistic effect between the components.

[0110] On the other hand, to evaluate the sustained-release effect of the whitening skin care product of this formula, the whitening skin care products of each of the above examples were applied to pig skin. The pig skin was then tested at different time intervals to determine whether it contained whitening skin care components such as gallnut, calyx leaf extract, sodium hyaluronate, ectoine, and collagen. The duration of the whitening skin care product's effect was determined by the time when these components were no longer detected. The test results of Examples 1-10 are shown in Table 3 below:

[0111] Table 3:

[0112] Experimental group Time until whitening components are undetectable (h) Example 1 ＞6 Example 2 ＞6 Example 3 ＞6 Example 4 ＞6 Example 5 ＞6 Example 6 ＞6 Example 7 4 Example 8 4 Example 9 1 Example 10 3

[0113] In addition, the same method was used to test the whitening skin care products K and S from a certain foreign country on the market. Since they do not contain the smart microcapsule components of this formula, the duration of action of their whitening components is less than 1 hour.

[0114] The test results above show that, in whitening skincare products without smart microcapsules, the whitening components are completely lost within one hour. However, in formulas with smart microcapsules, the inclusion of the smart microcapsules allows for the slow, long-term release of the whitening component, collagen, through the encapsulation of the microcapsules. During the preparation of the skincare products, some whitening components, such as gallnut, calyx leaf extract, and ectoine, are also absorbed into the smart microcapsules. These components are then slowly released from the smart microcapsules during use, achieving a long-lasting whitening effect. In contrast, in commercially available whitening skincare products without smart microcapsules, the whitening components are completely lost within one hour.

[0115] It can be seen that the coordinated use of the smart microcapsules in this formula and the whitening skin care components such as gallnut, calyx leaf extract, and ectoine can significantly prolong the effective duration of the whitening skin care product.

[0116] The above embodiments and test data are only some applications and implementation methods of the present invention and do not limit the scope of the present invention. Through the above description, any person skilled in the art can see that the present invention is innovatively created using novel ideas and means and has obvious practicality and creativity.

Claims

1. A whitening skin care product comprising smart microcapsules, characterized in that: The invention mainly comprises the following ingredients in parts by weight: 25-30 parts by weight of gallnut, 5-10 parts by weight of calyx leaf extract, 1-2 parts by weight of sodium hyaluronate, 1-5 parts by weight of ectoine, 10-20 parts by weight of smart microcapsules, and an appropriate amount of solvent; Wherein, the calyx leaf extract is an extract obtained by extracting, alkalizing and purifying the calyx leaf; The smart microcapsules are prepared by the following steps: 1) dispersing the microcapsules and collagen in a solvent to prepare a dispersion; 2) dissolving polyvinyl alcohol in a solvent to prepare a polyvinyl alcohol solution; 3) uniformly mixing the dispersion and the polyvinyl alcohol solution, and allowing to stand for defoaming to obtain a mixed solution; 4) freezing the mixed solution from step 3) and then soaking it in water to obtain smart microcapsules; The smart microcapsules are hydrogel smart microcapsules, and the raw materials for preparing the hydrogel smart microcapsules include polyvinyl alcohol, microcapsules, and collagen. The mass ratio of the polyvinyl alcohol, microcapsules, and collagen is 1-10:1-10:0.1-2; The whitening skin care product containing the smart microcapsules is prepared by the following steps: a) mixing 25-30 parts by weight of gallnut, 5-10 parts by weight of calyx leaf extract, 1-2 parts by weight of sodium hyaluronate, 1-5 parts by weight of ectoine, and an appropriate amount of solvent, and dispersing the mixture at high speed by ultrasonication to obtain a mixture; b) mixing 10-20 parts by weight of the smart microcapsules with the mixture of step a), and dispersing the mixture by low-speed mechanical stirring to obtain a whitening skin care product.

2. The whitening skin care product comprising smart microcapsules according to any one of claim 1, characterized in that: The microcapsule comprises a core material and a wall material, wherein the wall material is selected from carbohydrates, colloidal substances, proteins or cellulose; and the core material is selected from lauric acid or polyethylene glycol.

3. The whitening skin care product comprising smart microcapsules according to claim 2, characterized in that: The carbohydrate is selected from maltodextrin, cyclodextrin or corn starch; the colloid substance is selected from gum arabic, alginate or locust gum; the protein is selected from soy protein or gelatin; and the cellulose is selected from methyl cellulose, ethyl cellulose or carboxymethyl cellulose.

4. A method for preparing a whitening skin care product comprising smart microcapsules according to claim 1, characterized in that: include: a) mixing 25-30 parts by weight of gallnut, 5-10 parts by weight of calyx leaf extract, 1-2 parts by weight of sodium hyaluronate, 1-5 parts by weight of ectoine, and an appropriate amount of solvent, and dispersing the mixture at high speed by ultrasonication to obtain a mixture; b) mixing 10-20 parts by weight of the smart microcapsules with the mixture of step a), and dispersing the mixture by low-speed mechanical stirring to obtain a whitening skin care product.

5. The preparation method according to claim 4, characterized in that: The preparation method of the smart microcapsule comprises the following steps: 1) dispersing the microcapsules and collagen in a solvent to prepare a dispersion; 2) dissolving polyvinyl alcohol in a solvent to prepare a polyvinyl alcohol solution; 3) uniformly mixing the dispersion and the polyvinyl alcohol solution, and allowing to stand for defoaming to obtain a mixed solution; 4) The mixed solution of step 3) is frozen and then immersed in water to obtain smart microcapsules.

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