Eye mask using microcapsule technology and preparation method thereof

Abstract

The invention discloses an eye mask using microcapsule technology and a preparation method thereof, and belongs to the technical field of eye mask preparation. The preparation method of the eye mask using microcapsule technology comprises the following steps: step (1): evenly apply an antibacterial and moisturizing gel on the surface of a non-woven fabric, dry it, then spray a microcapsule eye protection substance on the surface of the non-woven fabric to obtain an inner cover layer, then add a heating substance to the non-woven fabric to obtain a heating layer, and then use glue to bond the inner cover layer, the heating layer and the outer cover layer to obtain an eye mask body; step (2): bond the eye mask body and the ear loops by glue to obtain an eye mask using microcapsule technology. The eye mask prepared by the method has antibacterial, moisturizing and comfortable properties, and can also reduce dark circles and relieve eye fatigue.

Description

Technical Field

[0001] The invention belongs to the technical field of eye mask preparation, and in particular relates to an eye mask utilizing microcapsule technology and a preparation method thereof. Background Art

[0002] As the pace of modern life accelerates, people are under increasing pressure, and sleep quality has become a common concern. As a tool to assist sleep, the effectiveness of eye masks is gradually recognized by people. However, most traditional eye masks have a single function and cannot meet people's pursuit of diversified and personalized needs. Therefore, researching and developing eye mask products with more functions and better experience has become an important trend in the industry.

[0003] Microencapsulation technology is a technology that encapsulates solid, liquid or gaseous substances in tiny, sealed capsules. This technology has been widely used in many fields in recent years, especially in the fields of healthcare and personal care products. As a common personal care product, the functions and experience of eye masks are constantly being innovated and improved. Microencapsulation technology, with its unique advantages, provides the possibility for the innovation of eye mask products. By encapsulating active ingredients such as nutrients, drugs or fragrances in microcapsules, these ingredients can be slowly released and have a lasting effect.

[0004] Patent CN 104622681 B discloses a steam eye mask, including a steam heating generating part and an essential oil generating part, wherein the steam heating generating part heats the essential oil generating part through an oxidative metal oxidation reaction, and the essential oil generating part is made of the following raw materials (volume fraction): 15-20% emulsifier, 30-35% compound essential oil, 45-55% water; wherein the compound essential oil includes the following raw materials (volume fraction): 0.1% to 5% agarwood essential oil, 0.2-5% lily essential oil or 0.2-5% green tea essential oil, 90-95% sweet almond essential oil. The invention applies agarwood essential oil to the steam eye mask, and by appropriately reducing the proportion of agarwood essential oil in the compound essential oil, not only does it not cause a burning sensation to the eyes, but it plays a key role in relieving eye fatigue, relieving eye fatigue and sleep problems, but the antibacterial and moisturizing properties of the eye mask obtained by this method, as well as its ability to reduce dark circles and relieve eye fatigue, still have room for improvement. Summary of the invention

[0005] The purpose of the present invention is to provide an eye mask using microcapsule technology and a preparation method thereof, so as to solve the technical problems of the prior art eye masks in terms of antibacterial and moisturizing properties and poor effects on reducing dark circles and relieving eye fatigue.

[0006] In order to achieve the above object, the present invention adopts the following technical solutions:

[0007] The invention provides an eye mask using microcapsule technology, comprising an eye mask body and hanging ears connected to the eye mask body, wherein the eye mask body comprises an inner cover layer, a heating layer and an outer cover layer, wherein the inner cover layer is composed of non-woven fabric, antibacterial moisturizing gel and microcapsule eye protection material, the heating layer is composed of non-woven fabric and heating material, the outer side of the heating layer is tightly combined with the outer cover layer, and the eye mask body and the hanging ears are bonded by glue.

[0008] Preferably, the method for preparing the antibacterial moisturizing gel comprises the following steps:

[0009] S1: dissolving chitosan in an acetic acid solution, bubbling with nitrogen to remove oxygen, to obtain a chitosan solution, and simultaneously dissolving disuccinimidyl suberate sulfonic acid sodium salt and 4-hydroxy-3-methoxy-DL-mandelic acid in an ethanol solution to obtain a mixed solution, adding the mixed solution to the chitosan solution with a syringe, stirring at room temperature for reaction, and after the reaction is completed, transferring it to a dialysis membrane, dialyzing, and drying to obtain a chitosan-based substance;

[0010] S2: Add the chitosan-based substance into deionized water, stir and dissolve, and obtain an antibacterial moisturizing gel.

[0011] In the above process, chitosan reacts with the carboxyl group in 4-hydroxy-3-methoxy-DL-mandelic acid to form an amide bond, and 4-hydroxy-3-methoxy-DL-mandelic acid is connected to chitosan to form a chitosan-based substance, which is then dissolved by deionized water to obtain an antibacterial moisturizing gel.

[0012] Preferably, in S1, the amount ratio of chitosan, acetic acid, disuccinimidyl suberate sulfonic acid sodium salt, 4-hydroxy-3-methoxy-DL-mandelic acid and ethanol is (1-2) g: (50-60) mL: (0.17-0.21) g: (0.15-0.45) g: (25-30) mL, the mass concentration of the acetic acid solution is 1wt%, the mass concentration of the ethanol solution is 50wt%, the stirring reaction time is 20-24h, and during the dialysis process, it is first dialyzed with a hydrochloric acid solution with a pH=4.5 for 48-50h, and then dialyzed with deionized water for 5-7h; in S2, the amount ratio of chitosan-based substance and deionized water is (1-2) g: (5-8) mL, and the stirring time is 2-4h.

[0013] Preferably, the method for preparing the microcapsule eye-protecting substance comprises the following steps:

[0014] Q1: Add triethylene glycol and n-octanoic acid to a container equipped with a water separator, a condenser, and a thermometer, slowly heat the system, stir, and measure the initial acid value of the reaction system after sufficient mixing, then add p-toluenesulfonic acid and cyclohexane, and heat the system again. Stop the reaction when the acid value no longer changes, perform vacuum distillation, add sodium bicarbonate to neutralize the unreacted raw materials, and then wash with water until neutral, and remove water by distillation under negative pressure to obtain intermediate product 1;

[0015] Q2: Add intermediate product 1 and L-lactic acid to a container, heat and stir to record the initial acid value, then add p-toluenesulfonic acid and cyclohexane, heat the system, react until the acid value no longer changes, stop the reaction, distill under reduced pressure, add sodium bicarbonate to neutralize the unreacted raw materials, wash with water to neutrality, and distill under reduced pressure to obtain intermediate product 2; add intermediate product 2 to a container, then add acetic anhydride, continue stirring to complete the reaction, distill under reduced pressure, add ammonium bicarbonate to neutralize the unreacted raw materials, and wash with water to neutrality to obtain a modified toughening agent;

[0016] Q3: Dry the raw Rehmannia root material, cool and crush it, then sieve it, and then place it in a reflux device, add petroleum ether, reflux and defatted it, and then dry it to obtain Rehmannia root residue; mix the Rehmannia root residue with distilled water, heat and extract it under water bath conditions, centrifuge, filter it with suction, combine the filtrate, and concentrate it to obtain a concentrated solution, discard the residue, deproteinize the concentrated solution, precipitate Rehmannia root crude polysaccharide with ethanol, dissolve it, dialyze it, centrifuge it, concentrate it, adjust the pH, and decolorize it in a water bath to obtain Rehmannia root polysaccharide;

[0017] Q4: Add soy protein isolate, Rehmannia glutinosa polysaccharide and modified toughening agent into distilled water, stir to obtain a shell solution, use the eye protection mixture as a receiver, add the shell solution dropwise into the receiver, react, let stand, and obtain microcapsule eye protection substance.

[0018] In the above process, triethylene glycol, n-octanoic acid, L-lactic acid and acetic anhydride are first used as raw materials, and p-toluenesulfonic acid and cyclohexane are used as catalysts to prepare a modified toughening agent. Subsequently, Rehmannia glutinosa polysaccharide is extracted by hot water, and the eye protection mixture is used as the core material, and soy protein isolate, Rehmannia glutinosa polysaccharide and the modified toughening agent are used as the wall material to prepare a microcapsule eye protection substance, wherein the synthesis process of the modified toughening agent is as follows:

[0019]

[0020] Preferably, in Q1, the molar ratio of triethylene glycol to n-octanoic acid is (1.2-2):(1-1.8), the heating temperature is 50-60°C, the stirring time is 30-40 min, the mass ratio of p-toluenesulfonic acid to cyclohexane is (0.8-1):(10-12), the heating temperature is 130-140°C, and the mass fraction of sodium bicarbonate is 5wt%.

[0021] Preferably, in Q2, the molar ratio of the intermediate product 1 and L-lactic acid is (1-2): (1.5-3), the heating and stirring temperature is 50-60°C, the mass ratio of p-toluenesulfonic acid and cyclohexane is (0.8-1): (10-12), the heating system temperature is 130-140°C, and the mass fraction of sodium bicarbonate is 5wt%; the molar ratio of the intermediate product 2 and acetic anhydride is (1-1.5): (1.2-1.8), the continuous stirring time is 4-6h, and the mass fraction of sodium bicarbonate is 5wt%.

[0022] Preferably, in Q3, the drying temperature is 60-70°C, the time is 3-4h, the sieve mesh is 40-50 mesh, the mass ratio of raw Rehmannia root material and petroleum ether is 1:(1.9-2.2), the reflux degreasing temperature is 65-70°C, the time is 2-3h, the drying temperature is 60-70°C, the dosage ratio of Rehmannia root residue and distilled water is 1g:(9-12)mL, the water bath temperature is 80-90°C, the extraction time is 3-4h, the centrifugal speed is 4000-5000rpm, the volume concentration of ethanol is 80vt%, the dialysis bag with a molecular weight of 1000Da is used for dialysis for 4h, the centrifugal speed is 3000-4000rpm, the time is 10-15min, the pH is adjusted to 8-8.2, the water bath temperature is 40-45°C, and the decolorization time is 2-3h.

[0023] Preferably, in Q4, the amount ratio of soy protein isolate, rehmannia polysaccharide, modified toughening agent and distilled water is (30-40) g: (10-22) g: (1-2) g: (50-60) mL, the stirring time is 3-4 h, and the eye protection mixture is a combination of one or more of sodium hyaluronate, sialic acid, ceramide, cactus polysaccharide, polypeptide, oligopeptide, positron, niacinamide, tremella heteropolysaccharide, glycerin, lutein extract, anthocyanin, carotene, retinol, dipotassium glycyrrhizate, aloe powder, menthol and natural borneol.

[0024] Preferably, the method for preparing an eye mask using microcapsule technology comprises the following steps:

[0025] Step (1): evenly apply the antibacterial moisturizing gel on the surface of the non-woven fabric, dry it, then spray the microcapsule eye protection material on the surface of the non-woven fabric to obtain an inner cover layer, then add the heat-generating material into the non-woven fabric to obtain a heating layer, and then use glue to bond the inner cover layer, the heating layer and the outer cover layer to obtain an eye mask body;

[0026] Step (2): The eye mask body and the ear loops are bonded together by glue to obtain an eye mask using microcapsule technology.

[0027] In summary, due to the adoption of the above technical solution, the beneficial effects of the present invention are:

[0028] 1. The present invention firstly uses chitosan, disuccinimidyl suberate sulfonic acid sodium salt and 4-hydroxy-3-methoxy-DL-mandelic acid to prepare an antibacterial moisturizing gel through a coupling method, then uses triethylene glycol, n-octanoic acid, L-lactic acid and acetic anhydride as raw materials to synthesize a modified toughening agent, then extracts Rehmannia glutinosa polysaccharide from raw Rehmannia glutinosa medicinal materials, uses soybean protein isolate, Rehmannia glutinosa polysaccharide and the modified toughening agent as wall materials, and uses the eye protection mixture as a core material to prepare a microcapsule eye protection substance, and adds the antibacterial moisturizing gel and the microcapsule eye protection substance into an eye mask, so as to improve the comfort, moisture retention and antibacterial property of the eye mask, and under the action of a heating system, effectively promotes the absorption of the gel and the eye protection substance by the eye skin, relieves eye fatigue, dilutes dark circles, and protects the eye skin.

[0029] 2. The present invention uses chitosan, disuccinimidyl suberate sulfonic acid sodium salt and 4-hydroxy-3-methoxy-DL-mandelic acid as raw materials, prepares an antibacterial moisturizing gel by a coupling method, and coats the gel on the surface of a non-woven fabric to prepare an inner cover layer, which is used in an eye mask to effectively improve the antibacterial property, moisturizing property and comfort of the eye mask. Chitosan interacts with the negative charge on the surface of bacterial cells through its positive charge to destroy the cell membrane structure of the bacteria, thereby achieving an antibacterial effect. The coupling reaction that occurs forms a more stable complex between chitosan and 4-hydroxy-3-methoxy-DL-mandelic acid. Enhanced its antibacterial properties; 4-hydroxy-3-methoxy-DL-mandelic acid is a compound containing multiple hydroxyl groups and has strong hydrophilicity. After the inner cover layer is coated with antibacterial moisturizing gel, it can absorb and lock the surrounding moisture to form a stable moisturizing environment. The presence of chitosan also helps to enhance the water retention of the gel, making the moisturizing effect more lasting; the antibacterial moisturizing gel has a certain elasticity and fluidity, and can be fine-tuned according to the shape of the eye skin, reducing friction and discomfort, and can also effectively isolate dust, bacteria and other harmful substances in the external environment, thereby improving the comfort of the eye mask.

[0030] 3. The present invention uses soybean protein isolate, rehmannia polysaccharide and modified toughening agent as wall materials and eye protection mixture as core material to prepare microcapsule eye protection material, and adds the microcapsule eye protection material to the non-woven fabric layer to prepare the inner cover layer. Under the action of the heating system, the eye mask can effectively improve the long-term eye protection of the eye skin, and also enhance the comfort of the eye mask. The wall material of the microcapsule structure can be gradually degraded within a certain period of time, so as to release the eye protection mixture in the core material, and the eye protection mixture can be continuously acted on the eye skin under the sustained release effect, thereby improving the eye protection effect; the substance in the core material can increase the moisture content of the skin, improve the elasticity and glossiness of the skin, remove free radicals, reduce the damage of oxidative stress to the skin, and dilute dark circles; it also has a cooling and soothing effect, and can relieve eye fatigue; and the porous structure of the non-woven fabric allows air to circulate freely, keeps the eye skin breathing unobstructed, and its soft texture also enhances the comfort of the eye mask. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0032] Figure 1 It is a front view of the eye mask with eye protection function of the present invention;

[0033] Figure 2 is a schematic diagram of the eye mask with eye protection effect of the present invention when the ears are not unfolded;

[0034] Figure 3 The invention discloses a cross-sectional view of an eye mask body structure of an eye mask having eye protection function.

[0035] Description of the drawings: 1. Eye mask body, 2. Ear loops, 3. Heating material, 4. Connection between the eye mask body and the elastic ear loops, 1-1. Inner cover layer, 1-2. Heating layer, 1-3. Outer cover layer. DETAILED DESCRIPTION

[0036] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0037] Example 1

[0038] See also Figure 1-Figure 3 As shown, the eye mask using microcapsule technology of this embodiment includes an eye mask body 1 and an ear hook 2 connected to the eye mask body, the eye mask body includes an inner cover layer 1-1, a heating layer 1-2 and an outer cover layer 1-3, the inner cover layer is composed of non-woven fabric, antibacterial moisturizing gel and microcapsule eye protection material, the heating layer is composed of non-woven fabric and heating material 3, the outer side of the heating layer is tightly combined with the outer cover layer, and the eye mask body and the ear hook are bonded by glue to form a connection 4.

[0039] Example 2

[0040] This embodiment discloses a method for preparing an antibacterial moisturizing gel, comprising the following steps:

[0041] S1: 1.5 g of chitosan was dissolved in 55 mL of acetic acid solution with a mass concentration of 1 wt%, and nitrogen was bubbled to remove oxygen to obtain a chitosan solution. Meanwhile, 0.19 g of disuccinimidyl suberate sulfonic acid sodium salt and 0.30 g of 4-hydroxy-3-methoxy-DL-mandelic acid were dissolved in 27.5 mL of ethanol solution with a mass concentration of 50 wt% to obtain a mixed solution. The mixed solution was added to the chitosan solution with a syringe, and the reaction was stirred at room temperature for 24 h. After the reaction was completed, it was transferred to a dialysis membrane and dialyzed, first with a hydrochloric acid solution with a pH of 4.5 for 48 h, and then with deionized water for 6 h, and dried to obtain a chitosan-based substance;

[0042] S2: Add 1.5 g of chitosan-based substance into 6.5 mL of deionized water and stir for 4 h to dissolve to obtain an antibacterial moisturizing gel.

[0043] This embodiment discloses a method for preparing a microcapsule eye-protecting substance, comprising the following steps:

[0044] Q1: 1.69 g of triethylene glycol and 1.4 g of n-octanoic acid were added to a container equipped with a water separator, a condenser, and a thermometer, the system was slowly heated to 50°C, stirred for 40 min, and the initial acid value of the reaction system was measured after sufficient mixing. Then, 0.09 g of p-toluenesulfonic acid and 1.1 g of cyclohexane were added, and the system was heated to 130°C. The reaction was stopped when the acid value no longer changed, and the reaction was distilled under reduced pressure. 5 wt% of sodium bicarbonate was added to neutralize the unreacted raw materials, and then washed with water until neutral, and water was removed by distillation under negative pressure to obtain intermediate product 1;

[0045] Q2: 3.8g of intermediate product 1 and 1.5g of L-lactic acid were added to a container, heated and stirred at 60°C to record the initial acid value, and then 0.09g of p-toluenesulfonic acid and 1.1g of cyclohexane were added, and the system was heated at 140°C. The reaction was stopped when the acid value no longer changed, and the reaction was distilled under reduced pressure. 5wt% of sodium bicarbonate was added to neutralize the unreacted raw materials, and then washed with water until neutral, and distilled under reduced pressure to obtain intermediate product 2; 4.29g of intermediate product 2 was added to a container, and 1.25g of acetic anhydride was added, and the reaction was completed by stirring for 6h, and distilled under reduced pressure. 5wt% of ammonium bicarbonate was added to neutralize the unreacted raw materials and washed with water until neutral to obtain a modified toughening agent;

[0046] Q3: 1g of raw Rehmannia root was dried at 70℃ for 4h, cooled and crushed, and then passed through a 50-mesh sieve, then placed in a reflux device, 2.1g of petroleum ether was added, refluxed at 70℃ for degreasing for 3h, and then dried at 60℃ to obtain Rehmannia root residue; 1g of Rehmannia root residue was mixed with 11mL of distilled water, heated and extracted in a water bath at 90℃ for 4h, centrifuged at 5000rpm, filtered, the filtrate was combined, and concentrated to obtain a concentrated solution, the residue was discarded, the concentrated solution was deproteinized, and crude Rehmannia root polysaccharide was precipitated with ethanol with a volume concentration of 80vt%, dissolved, dialyzed with a dialysis bag with a molecular weight of 1000Da for 4h, centrifuged at 4000rpm for 15min, concentrated, adjusted to pH=8, and decolorized in a water bath at 45℃ for 3h to obtain Rehmannia root polysaccharide;

[0047] Q4: Add 35g of soy protein isolate, 16g of Rehmannia glutinosa polysaccharide and 1.5g of modified toughening agent to 55mL of distilled water and stir for 3h to obtain a shell solution. Use the eye protection mixture as the receiver. The eye protection mixture is a mixture of sodium hyaluronate, sialic acid, ceramide, cactus polysaccharide, polypeptide, oligopeptide, bosine, niacinamide and dipotassium glycyrrhizinate. Add the shell solution dropwise to the receiver, react, and let stand to obtain microcapsule eye protection substance.

[0048] This embodiment discloses a method for preparing an eye mask using microcapsule technology, comprising the following steps:

[0049] Step (1): evenly apply the antibacterial moisturizing gel on the surface of the non-woven fabric and dry it, then spray the microcapsule eye protection material on the surface of the non-woven fabric to obtain an inner cover layer, then add a heating material to the non-woven fabric, the heating material is composed of 11g iron powder, 6g activated carbon and 1.5mL water, to obtain a heating layer, and then use glue to bond the inner cover layer, the heating layer and the outer cover layer to obtain an eye mask body;

[0050] Step (2): The eye mask body and the ear loops are bonded together by glue to obtain an eye mask using microcapsule technology.

[0051] Example 3

[0052] This embodiment discloses a method for preparing an antibacterial moisturizing gel, comprising the following steps:

[0053] S1: Dissolve 1g of chitosan in 50mL of acetic acid solution with a mass concentration of 1wt%, and bubbling with nitrogen to remove oxygen to obtain a chitosan solution. Meanwhile, dissolve 0.17g of disuccinimidyl suberate sulfonic acid sodium salt and 0.15g of 4-hydroxy-3-methoxy-DL-mandelic acid in 25mL of ethanol solution with a mass concentration of 50wt% to obtain a mixed solution. Add the mixed solution to the chitosan solution with a syringe, stir and react at room temperature for 24h. After the reaction is completed, transfer it to a dialysis membrane and dialyze it, first with a hydrochloric acid solution with a pH of 4.5 for 48h, then with deionized water for 6h, and dry it to obtain a chitosan-based substance.

[0054] S2: Add 1 g of chitosan-based substance into 5 mL of deionized water and stir for 4 h to dissolve to obtain an antibacterial moisturizing gel.

[0055] This embodiment discloses a method for preparing a microcapsule eye-protecting substance, comprising the following steps:

[0056] Q1: 1.27 g of triethylene glycol and 1 g of n-octanoic acid were added to a container equipped with a water separator, a condenser, and a thermometer, the system was slowly heated to 50°C, stirred for 40 min, and the initial acid value of the reaction system was measured after sufficient mixing. Then, 0.09 g of p-toluenesulfonic acid and 1.1 g of cyclohexane were added, and the system was heated to 130°C. The reaction was stopped when the acid value no longer changed, and the reaction was distilled under reduced pressure. 5 wt% of sodium bicarbonate was added to neutralize the unreacted raw materials, and then washed with water until neutral, and water was removed by distillation under negative pressure to obtain intermediate product 1;

[0057] Q2: 2.53g of intermediate product 1 and 2g of L-lactic acid were added to a container, heated and stirred at 60°C to record the initial acid value, and then 0.09g of p-toluenesulfonic acid and 1.1g of cyclohexane were added, and the system was heated at 140°C. The reaction was stopped when the acid value no longer changed, and the reaction was distilled under reduced pressure. 5wt% of sodium bicarbonate was added to neutralize the unreacted raw materials, and then washed with water until neutral, and distilled under reduced pressure to obtain intermediate product 2; 3.43g of intermediate product 2 was added to a container, and 1g of acetic anhydride was added, and the reaction was completed by stirring for 6h, and distilled under reduced pressure. 5wt% of ammonium bicarbonate was added to neutralize the unreacted raw materials and washed with water until neutral to obtain a modified toughening agent;

[0058] Q3: 1g of raw Rehmannia root material was dried at 70℃ for 4h, cooled and crushed, and then passed through a 50-mesh sieve, and then placed in a reflux device, 2.2g of petroleum ether was added, and refluxed at 70℃ for degreasing for 3h, and then dried at 60℃ to obtain Rehmannia root residue; 1g of Rehmannia root residue was mixed with 9mL of distilled water, heated and extracted in a water bath at 90℃ for 4h, centrifuged at 5000rpm, filtered, the filtrate was combined, and concentrated to obtain a concentrated solution, the residue was discarded, and the concentrated solution was deproteinized, and the crude Rehmannia root polysaccharide was precipitated with ethanol with a volume concentration of 80vt%, dissolved, dialyzed with a dialysis bag with a molecular weight of 1000Da for 4h, centrifuged at 4000rpm for 15min, concentrated, adjusted to pH=8, and decolorized in a water bath at 45℃ for 3h to obtain Rehmannia root polysaccharide;

[0059] Q4: Add 30g of soy protein isolate, 10g of Rehmannia glutinosa polysaccharide and 1g of modified toughening agent to 50mL of distilled water, stir for 3h to obtain a shell solution, and use the eye protection mixture as the receiver. The eye protection mixture is a mixture of sodium hyaluronate, sialic acid, ceramide, cactus polysaccharide, polypeptide, oligopeptide, bosine, niacinamide and dipotassium glycyrrhizinate. Add the shell solution dropwise to the receiver, react, and let stand to obtain microcapsule eye protection substance.

[0060] This embodiment discloses a method for preparing an eye mask using microcapsule technology, comprising the following steps:

[0061] Step (1): Step (1): evenly apply the antibacterial moisturizing gel on the surface of the non-woven fabric, dry it, then spray the microcapsule eye protection material on the surface of the non-woven fabric to obtain an inner cover layer, then add a heating material to the non-woven fabric, the heating material is composed of 11g iron powder, 6g activated carbon and 1.5mL water, to obtain a heating layer, and then use glue to bond the inner cover layer, the heating layer and the outer cover layer to obtain an eye mask body;

[0062] Step (2): The eye mask body and the ear loops are bonded together by glue to obtain an eye mask using microcapsule technology.

[0063] Example 4

[0064] This embodiment discloses a method for preparing an antibacterial moisturizing gel, comprising the following steps:

[0065] S1: 2 g of chitosan was dissolved in 60 mL of acetic acid solution with a mass concentration of 1 wt%, and nitrogen was bubbled to remove oxygen to obtain a chitosan solution. Meanwhile, 0.21 g of disuccinimidyl suberate sulfonic acid sodium salt and 0.45 g of 4-hydroxy-3-methoxy-DL-mandelic acid were dissolved in 30 mL of ethanol solution with a mass concentration of 50 wt% to obtain a mixed solution. The mixed solution was added to the chitosan solution with a syringe, and the mixture was stirred at room temperature for 24 h. After the reaction was completed, the mixture was transferred to a dialysis membrane and dialyzed, first with a hydrochloric acid solution with a pH of 4.5 for 48 h, and then with deionized water for 6 h, and dried to obtain a chitosan-based substance;

[0066] S2: Add 2 g of chitosan-based substance into 8 mL of deionized water and stir for 4 h to dissolve to obtain an antibacterial moisturizing gel.

[0067] This embodiment discloses a method for preparing a microcapsule eye-protecting substance, comprising the following steps:

[0068] Q1: 2.11 g of triethylene glycol and 1.8 g of n-octanoic acid were added to a container equipped with a water separator, a condenser, and a thermometer, the system was slowly heated to 50°C, stirred for 40 min, and the initial acid value of the reaction system was measured after sufficient mixing. Then, 0.09 g of p-toluenesulfonic acid and 1.1 g of cyclohexane were added, and the system was heated to 130°C. The reaction was stopped when the acid value no longer changed, and the reaction was performed under reduced pressure distillation. 5 wt% of sodium bicarbonate was added to neutralize the unreacted raw materials, and then washed with water until neutral, and water was removed by distillation under negative pressure to obtain intermediate product 1;

[0069] Q2: 5.07g of intermediate product 1 and 1.7g of L-lactic acid were added to a container, first heated and stirred at 60°C to record the initial acid value, then 0.09g of p-toluenesulfonic acid and 1.1g of cyclohexane were added, and the system was heated at 140°C. The reaction was stopped when the acid value no longer changed, and the reaction was distilled under reduced pressure. After adding 5wt% sodium bicarbonate to neutralize the unreacted raw materials, the mixture was washed with water until neutral, and distilled under reduced pressure to obtain intermediate product 2; 5.15g of intermediate product 2 was added to a container, and then 1.5g of acetic anhydride was added. The reaction was stirred for 6h to complete the reaction, and distilled under reduced pressure. After adding 5wt% ammonium bicarbonate to neutralize the unreacted raw materials, the mixture was washed with water until neutral, and a modified toughening agent was obtained;

[0070] Q3: 1g of raw Rehmannia root material was dried at 70℃ for 4h, cooled and crushed, and then passed through a 50-mesh sieve, and then placed in a reflux device, 1.9g of petroleum ether was added, and refluxed at 70℃ for degreasing for 3h, and then dried at 60℃ to obtain Rehmannia root residue; 1g of Rehmannia root residue was mixed with 12mL of distilled water, heated and extracted in a water bath at 90℃ for 4h, centrifuged at 5000rpm, filtered, the filtrate was combined, and concentrated to obtain a concentrated solution, the residue was discarded, and the concentrated solution was deproteinized, and crude Rehmannia root polysaccharide was precipitated with ethanol with a volume concentration of 80vt%, dissolved, dialyzed with a dialysis bag with a molecular weight of 1000Da for 4h, centrifuged at 4000rpm for 15min, concentrated, adjusted to pH=8, and decolorized in a water bath at 45℃ for 3h to obtain Rehmannia root polysaccharide;

[0071] Q4: Add 40g of soy protein isolate, 22g of Rehmannia glutinosa polysaccharide and 2g of modified toughening agent to 60mL of distilled water and stir for 3h to obtain a shell solution. Use the eye protection mixture as the receiver. The eye protection mixture is a mixture of sodium hyaluronate, sialic acid, ceramide, cactus polysaccharide, polypeptide, oligopeptide, bosine, niacinamide and dipotassium glycyrrhizinate. Add the shell solution dropwise to the receiver, react, and let stand to obtain microcapsule eye protection substance.

[0072] This embodiment discloses a method for preparing an eye mask using microcapsule technology, comprising the following steps:

[0073] Step (1): Step (1): evenly apply the antibacterial moisturizing gel on the surface of the non-woven fabric, dry it, then spray the microcapsule eye protection material on the surface of the non-woven fabric to obtain an inner cover layer, then add a heating material to the non-woven fabric, the heating material is composed of 11g iron powder, 6g activated carbon and 1.5mL water, to obtain a heating layer, and then use glue to bond the inner cover layer, the heating layer and the outer cover layer to obtain an eye mask body;

[0074] Step (2): The eye mask body and the ear loops are bonded together by glue to obtain an eye mask using microcapsule technology.

[0075] Comparative Example 1

[0076] Comparative Example 1 Compared with Example 2, in the process of preparing the antibacterial moisturizing gel in Comparative Example 1, no chitosan was added, and other conditions remained unchanged.

[0077] Comparative Example 2

[0078] Comparative Example 2 Compared with Example 2, in the process of preparing the antibacterial moisturizing gel in Comparative Example 2, 4-hydroxy-3-methoxy-DL-mandelic acid was not added, and other conditions remained unchanged.

[0079] Comparative Example 3

[0080] Comparative Example 3 Compared with Example 2, in the process of preparing the microcapsule eye protection material in Comparative Example 3, no modified toughening agent is added, and other conditions remain unchanged.

[0081] Comparative Example 4

[0082] Comparative Example 4 Compared with Example 2, in the process of preparing the microcapsule eye-protecting substance in Comparative Example 4, no Rehmannia glutinosa polysaccharide was added, and other conditions remained unchanged.

[0083] Comparative Example 5

[0084] Comparative Example 5 Compared with Example 2, in the process of preparing the microcapsule eye-protecting substance in Comparative Example 5, no eye-protecting mixture is added, and other conditions remain unchanged.

[0085] Comparative Example 6

[0086] Comparative Example 6 Compared with Example 2, in the process of preparing the eye mask using microcapsule technology, no antibacterial moisturizing gel is added in Comparative Example 6, and other conditions remain unchanged.

[0087] Comparative Example 7

[0088] Comparative Example 7 Compared with Example 2, in the process of preparing the eye mask using microcapsule technology, no microcapsule eye protection substance is added in Comparative Example 7, and other conditions remain unchanged.

[0089] 1. Evaluation of antibacterial and moisturizing properties

[0090] The performance of the eye masks prepared using microcapsule technology in Examples 2-4 and Comparative Examples 1-7 was tested. The antibacterial properties of the samples were tested according to the standard GB / T 20944.1-2007, and the moisturizing properties of the samples were evaluated according to the standard QB / T4256-2011. The test results are shown in Table 1:

[0091] Table 1

[0092]

[0093]

[0094] From the test results in Table 1, it can be seen that the eye mask prepared by the microcapsule technology in Examples 2-4 of the present invention has excellent antibacterial and moisturizing properties. According to the standard QB / T 4256-2011, the moisturizing properties of the samples are evaluated. The positive results show that the moisture content of the stratum corneum in the test area before and after the use of the product is significantly different, indicating that the tested sample has a moisturizing effect. The negative results show that there is no significant difference in the moisture content of the stratum corneum in the test area before and after the use of the product, indicating that the tested sample does not have a moisturizing effect. From the comparison between Comparative Example 1 and Examples 2-4, it can be seen that the addition of chitosan can effectively improve the antibacterial property of the eye mask; from the comparison between Comparative Example 2 and Examples 2-4, it can be seen that the addition of 4-hydroxy-3-methoxy-DL-mandelic acid can effectively improve the moisturizing property of the eye mask; from the comparison between Comparative Example 6 and Examples 2-4, it can be seen that the addition of antibacterial moisturizing gel can effectively improve the antibacterial and moisturizing properties of the eye mask.

[0095] 2. Evaluation of dark circles reduction performance

[0096] 50 volunteers were selected and divided into 10 groups on average. The skin around the left eye or right eye was randomly selected as the experimental group and the control group. The volunteers used the corresponding eye mask once in the morning and evening every day. The experimental group used the prepared sample eye mask, and the control group did not use the eye mask for 30 consecutive days. No other cosmetics were used on the test site during the test. Follow-up was once at 0d and 30d, for a total of 2 times. Before each test, the subjects were required to clean their eyes with clean water, wipe the eyes with a paper towel without fluorescent agent, and sit quietly for at least 20 minutes at 20-22℃ and 40-60% relative humidity. The measurement personnel used the stratum corneum moisture content test probe and the skin color probe to measure the fixed area positions around the left and right eyes of the subjects, and recorded the stratum corneum moisture content value and the skin ITA value. Each measurement area was measured 3 times and the average value was taken. The test of the same subject must be completed by the same tester using the same instrument. The test probe was cleaned between 2 measurements. The test results are shown in Table 2:

[0097] Table 2

[0098]

[0099]

[0100] From the test results in Table 2, it can be seen that the eye masks prepared by microcapsule technology in Examples 2-4 of the present invention have the effect of reducing dark circles. The larger the ITA difference, the more obvious the effect of reducing dark circles. From the comparison between Comparative Example 3 and Examples 2-4, it can be seen that adding a modified toughening agent can effectively reduce dark circles; from the comparison between Comparative Example 4 and Examples 2-4, it can be seen that adding Rehmannia glutinosa polysaccharide can effectively reduce dark circles; from the comparison between Comparative Example 5 and Examples 2-4, it can be seen that adding an eye protection mixture can effectively reduce dark circles; from the comparison between Comparative Example 7 and Examples 2-4, it can be seen that adding a microcapsule eye protection substance can effectively reduce dark circles.

[0101] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

[0102] The preferred embodiments of the present invention disclosed above are only used to help explain the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to only specific implementation methods. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can understand and use the present invention well. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. Eye mask using microcapsule technology, characterized in that: The invention comprises an eye mask body and a hanging ear connected to the eye mask body, wherein the eye mask body comprises an inner cover layer, a heating layer and an outer cover layer, wherein the inner cover layer is composed of a non-woven fabric, an antibacterial moisturizing gel and a microcapsule eye protection substance, the heating layer is composed of a non-woven fabric and a heating substance, the outer side of the heating layer is tightly combined with the outer cover layer, and the eye mask body and the hanging ear are bonded by glue, wherein the antibacterial moisturizing gel is prepared from chitosan and 4-hydroxy-3-methoxy-DL-mandelic acid, and the microcapsule eye protection substance is prepared from a modified toughening agent, Rehmannia glutinosa polysaccharide, soy protein isolate and an eye protection mixture; The method for preparing the antibacterial moisturizing gel comprises the following steps: S1: dissolving chitosan in an acetic acid solution, bubbling with nitrogen to remove oxygen, to obtain a chitosan solution, and simultaneously dissolving disuccinimidyl suberate sulfonic acid sodium salt and 4-hydroxy-3-methoxy-DL-mandelic acid in an ethanol solution to obtain a mixed solution, adding the mixed solution to the chitosan solution with a syringe, stirring at room temperature for reaction, and after the reaction is completed, transferring it to a dialysis membrane, dialyzing, and drying to obtain a chitosan-based substance; S2: adding chitosan-based substances into deionized water, stirring and dissolving, and obtaining an antibacterial moisturizing gel; The method for preparing the microcapsule eye-protecting substance comprises the following steps: Q1: Add triethylene glycol and n-octanoic acid to a container equipped with a water separator, a condenser, and a thermometer, slowly heat the system, stir, and measure the initial acid value of the reaction system after sufficient mixing, then add p-toluenesulfonic acid and cyclohexane, and heat the system again. Stop the reaction when the acid value no longer changes, perform vacuum distillation, add sodium bicarbonate to neutralize the unreacted raw materials, and then wash with water until neutral, and remove water by distillation under negative pressure to obtain intermediate product 1; Q2: Add intermediate product 1 and L-lactic acid to a container, heat and stir to record the initial acid value, then add p-toluenesulfonic acid and cyclohexane, heat the system, react until the acid value no longer changes, stop the reaction, distill under reduced pressure, add sodium bicarbonate to neutralize the unreacted raw materials, wash with water to neutrality, and distill under reduced pressure to obtain intermediate product 2; add intermediate product 2 to a container, then add acetic anhydride, continue stirring to complete the reaction, distill under reduced pressure, add ammonium bicarbonate to neutralize the unreacted raw materials, and wash with water to neutrality to obtain a modified toughening agent; Q3: Dry the raw Rehmannia root material, cool and crush it, then sieve it, and then place it in a reflux device, add petroleum ether, reflux and defatted it, and then dry it to obtain Rehmannia root residue; mix the Rehmannia root residue with distilled water, heat and extract it under water bath conditions, centrifuge, filter it with suction, combine the filtrate, and concentrate it to obtain a concentrated solution, discard the residue, deproteinize the concentrated solution, precipitate Rehmannia root crude polysaccharide with ethanol, dissolve it, dialyze it, centrifuge it, concentrate it, adjust the pH, and decolorize it in a water bath to obtain Rehmannia root polysaccharide; Q4: Add soy protein isolate, Rehmannia glutinosa polysaccharide and modified toughening agent into distilled water, stir to obtain a shell solution, use the eye protection mixture as a receiver, add the shell solution dropwise into the receiver, react, let stand, and obtain microcapsule eye protection substance.

2. The eye mask using microcapsule technology according to claim 1, characterized in that: In the S1, the amount ratio of chitosan, acetic acid, disuccinimidyl suberate sulfonic acid sodium salt, 4-hydroxy-3-methoxy-DL-mandelic acid and ethanol is (1-2) g: (50-60) mL: (0.17-0.21) g: (0.15-0.45) g: (25-30) mL, the mass concentration of the acetic acid solution is 1wt%, the mass concentration of the ethanol solution is 50wt%, the stirring reaction time is 20-24h, and during the dialysis process, the dialyzate is first used with a hydrochloric acid solution with a pH value of 4.5 for 48-50h, and then dialyzed with deionized water for 5-7h; in the S2, the amount ratio of the chitosan-based substance and deionized water is (1-2) g: (5-8) mL, and the stirring time is 2-4h.

3. The eye mask using microcapsule technology according to claim 1, characterized in that: In Q1, the molar ratio of triethylene glycol to n-octanoic acid is (1.2-2): (1-1.8), the heating temperature is 50-60°C, the stirring time is 30-40 min, the mass ratio of p-toluenesulfonic acid to cyclohexane is (0.8-1): (10-12), the heating temperature is 130-140°C, and the mass fraction of sodium bicarbonate is 5wt%.

4. The eye mask using microcapsule technology according to claim 1, characterized in that: In Q2, the molar ratio of the intermediate product 1 and L-lactic acid is (1-2): (1.5-3), the heating and stirring temperature is 50-60°C, the mass ratio of p-toluenesulfonic acid and cyclohexane is (0.8-1): (10-12), the heating system temperature is 130-140°C, and the mass fraction of sodium bicarbonate is 5wt%; the molar ratio of the intermediate product 2 and acetic anhydride is (1-1.5): (1.2-1.8), the continuous stirring time is 4-6h, and the mass fraction of sodium bicarbonate is 5wt%.

5. The eye mask using microcapsule technology according to claim 1, characterized in that: In the Q3, the drying temperature is 60-70°C, the time is 3-4h, the sieve mesh is 40-50 mesh, the mass ratio of raw Rehmannia root material and petroleum ether is 1:(1.9-2.2), the reflux degreasing temperature is 65-70°C, the time is 2-3h, the drying temperature is 60-70°C, the dosage ratio of Rehmannia root residue and distilled water is 1g:(9-12)mL, the water bath temperature is 80-90°C, the extraction time is 3-4h, the centrifugal speed is 4000-5000rpm, the volume concentration of ethanol is 80vt%, the dialysis bag with a molecular weight of 1000Da is used for dialysis for 4h, the centrifugal speed is 3000-4000rpm, the time is 10-15min, the pH is adjusted to 8-8.2, the water bath temperature is 40-45°C, and the decolorization time is 2-3h.

6. The eye mask using microcapsule technology according to claim 1, characterized in that: In the Q4, the dosage ratio of soy protein isolate, rehmannia polysaccharide, modified toughening agent and distilled water is (30-40) g: (10-22) g: (1-2) g: (50-60) mL, the stirring time is 3-4 hours, and the eye protection mixture is a combination of one or more of sodium hyaluronate, sialic acid, ceramide, cactus polysaccharide, polypeptide, oligopeptide, positron, niacinamide, tremella heteropolysaccharide, glycerin, lutein extract, anthocyanin, carotene, retinol, dipotassium glycyrrhizate, aloe powder, menthol and natural borneol.

7. The method for preparing an eye mask using microcapsule technology according to any one of claims 1 to 6, characterized in that: The following steps are involved: Step (1): evenly apply the antibacterial moisturizing gel on the surface of the non-woven fabric, dry it, then spray the microcapsule eye protection material on the surface of the non-woven fabric to obtain an inner cover layer, then add the heat-generating material into the non-woven fabric to obtain a heating layer, and then use glue to bond the inner cover layer, the heating layer and the outer cover layer to obtain an eye mask body; Step (2): The eye mask body and the ear loops are bonded together by glue to obtain an eye mask using microcapsule technology.

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