A closed-loop electrode for monitoring cerebral cortex and nuclei and micro-drug administration

Abstract

The present invention relates to the field of biological electrodes, and in particular to a closed-loop electrode for monitoring cerebral cortex and nuclei and micro-dosing, including a signal acquisition component and a micro-dosing component, the signal acquisition component including an electrode unit, a skull nail and an electrode connector, the electrode unit is attached to the surface of the skull, the skull nail penetrates the electrode unit and the skull and is inserted into the cerebral cortex, and the electrode connector connects the electrode unit and the recording terminal; the micro-dosing component includes a dosing sleeve, a dosing inner core and a protective cap, the dosing sleeve passes through the skull and is implanted into the dosing site of the brain area, the dosing inner core and the protective cap are both detachably connected to the dosing sleeve, the dosing sleeve is used to guide the dosing inner core through itself to reach the dosing site, and the protective cap is used to connect the dosing sleeve to seal the dosing sleeve. The embodiment of the present invention integrates a signal acquisition component and a micro-dosing component, and can administer drugs to the target brain area without removing the electrodes, while collecting activity signals of neural units.

Description

Technical Field

[0001] The invention relates to the field of biological electrodes, and in particular to a closed-loop electrode for monitoring cerebral cortex and nuclei and micro-drug administration. Background Art

[0002] EEG signals are generated by the discharge of numerous neurons in the brain. Obtaining these neural discharge signals can help people identify or understand the brain's mechanism of action or conduct regulatory intervention. The traditional method of intervening and recording neuronal activity is to administer drugs to the receptor neurons and then record the neuronal activity.

[0003] The traditional method of recording EEG signals is to implant a drug delivery tube into the target area (such as under the skull) of a recipient (such as a mouse) to deliver the drug, and then implant a recording electrode under the skull to record neuronal activity. When the drug needs to be delivered again, the recording electrode is removed and then implanted again after delivery.

[0004] Multiple experiments require multiple electrode implantations, which causes greater damage to the receptors, high surgical risks, and low surgical efficiency. In addition, the positions of multiple implanted recording electrodes may deviate, resulting in low experimental accuracy. Summary of the invention

[0005] The purpose of the present invention is to provide a closed-loop electrode for monitoring the cerebral cortex and nuclei and for micro-drug administration, so as to solve the problem that the traditional method of recording EEG signals requires the removal of electrodes before each drug administration and the repeated implantation of electrodes after drug administration.

[0006] In order to solve the above technical problems, the present invention specifically provides the following technical solutions:

[0007] A closed-loop electrode for monitoring cerebral cortex and nuclei and micro-dosing, comprising a signal acquisition component and a micro-dosing component, both of which are fixed to the surface of the skull and penetrate the skull to contact the cerebral cortex; the signal acquisition component comprises an electrode unit, a skull nail and an electrode connector, the electrode unit is attached to the surface of the skull, the skull nail penetrates the electrode unit and the skull and is inserted into the cerebral cortex, and the electrode connector connects the electrode unit and a recording terminal; the micro-dosing component comprises a dosing sleeve, a dosing core and a protective cap, the dosing sleeve is implanted into a dosing site in the brain region through the skull, the dosing core and the protective cap are both detachably connected to the dosing sleeve, the dosing sleeve is used to guide the dosing core to pass through itself to reach the dosing site, and the protective cap is used to connect the dosing sleeve to seal the dosing sleeve.

[0008] Furthermore, the electrode unit includes: a base layer and a conductive layer, wherein the base layer is used to wrap the conductive layer, the base layer has flexibility and insulation, and the conductive layer is used to electrically connect the skull nail and the electrode connector.

[0009] Furthermore, a plurality of conductive contacts are installed inside the base layer, and the conductive contacts are evenly and densely distributed according to the shape of the skull. The conductive layer includes a plurality of circuits, and the electrode connector is connected to each of the conductive contacts through the circuits.

[0010] Furthermore, a mounting hole is formed at a position of the base layer corresponding to the conductive contact, and the conductive contact is exposed inside the mounting hole. The mounting hole allows the skull nail to pass through the base layer to fix the connection between the skull and the electrode unit and ensure effective contact between the skull nail and the conductive contact.

[0011] Furthermore, the base layer is made of a flexible film material with biocompatibility, the circuit is made of a non-absorbable conductive material, and the skull nail is made of a conductive material with biocompatibility.

[0012] Furthermore, the drug delivery sleeve includes a fixing part and a first capillary, wherein the fixing part is fixed on the skull, the fixing part and the first capillary are integrated, the fixing part is used to support the first capillary, and the first capillary is implanted into the target brain area to deliver the drug.

[0013] Furthermore, the protective cap includes a second nut and a blocking wire, the second nut can be threadedly connected to the fixing piece, the blocking wire and the second nut form a whole, and the blocking wire is used to be inserted into the first capillary to prevent body fluids inside the skull from entering the first capillary.

[0014] Furthermore, the drug delivery inner core includes a first nut and a second capillary, the first nut can be threadedly connected to the fixing piece, the second capillary is integrated with the first nut, and when the first nut is tightened on the fixing piece, the second capillary passes through the first capillary to reach the drug delivery site.

[0015] In another embodiment of the present invention, the drug delivery sleeve includes a fixing member and a third capillary, one end of the third capillary is implanted in the target brain area, the other end of the third capillary extends to the top of the fixing member, and the middle part of the third capillary forms a spherical chamber with a diameter larger than the third capillary, and the spherical chamber is provided with a through hole at a position deviating from the axis of the third capillary, and an incision is formed on one side of the upper half of the fixing member, and the incision starts from the top surface of the fixing member and extends downward along the axis direction of the fixing member to the through hole, so that the through hole is exposed to the outside of the fixing member; the protective cap includes a second nut and a blocking wire, the second nut can be threadedly connected to the fixing member, the blocking wire and the second nut form a whole, and the blocking wire is formed in one piece. The end of the wire is connected to a plug, which is a sphere or cylinder with a diameter larger than that of the blocking wire. The diameter of the plug is the same as that of the third capillary. The diameter of the through hole is larger than the diameter of the blocking wire and smaller than the diameter of the plug, so that the blocking wire can pass through the through hole but the plug cannot. The plug is used to be inserted into the third capillary to prevent body fluids inside the skull from entering the third capillary. One end of the blocking wire connected to the second nut is connected to a rotating part, and the rotating part is in the shape of a disk that can rotate around the second nut. The blocking wire is eccentrically connected to the rotating part, so that when the second nut is screwed on the fixing part, the blocking wire can always be located inside the incision.

[0016] Furthermore, the drug delivery inner core includes a first nut and a second capillary, the first nut can be threadedly connected to the fixing piece, the second capillary is integrated with the first nut, and when the first nut is tightened on the fixing piece, the second capillary passes through the third capillary to reach the drug delivery site.

[0017] Compared with the prior art, this application has the following beneficial effects:

[0018] Provided is a closed-loop electrode for monitoring cerebral cortex and nuclei and micro-drug administration. The embodiment of the present invention integrates a signal acquisition component and a micro-drug administration component, and can administer drugs to the target brain area without removing the electrodes, while acquiring activity signals of neural units, thereby solving the problem of traditional EEG signal recording methods that require the removal of electrodes before each drug administration and the need for repeated implantation of electrodes after drug administration. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the implementation methods of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for the implementation methods or the description of the prior art. Obviously, the drawings in the following description are only exemplary, and for ordinary technicians in this field, other implementation drawings can be derived from the provided drawings without creative work.

[0020] Figure 1 is a three-dimensional diagram of the drug administration state of the first embodiment of the present invention;

[0021] Figure 2 A three-dimensional diagram of a long-term maintenance state of the first embodiment of the present invention;

[0022] Figure 3 is a perspective view of an electrode unit according to a first embodiment of the present invention;

[0023] Figure 4 is a cross-sectional view of a micro-dosing assembly in a dosing state according to a second embodiment of the present invention;

[0024] Figure 5 A cross-sectional view of a micro-dose administration assembly in a long-term maintenance state according to a second embodiment of the present invention;

[0025] The numbers in the figure represent the following:

[0026] 1-electrode unit; 11-base layer; 111-mounting hole; 12-conductive layer; 121-circuit; 122-conductive contact; 2-skull nail; 3-electrode connector; 4-drug sleeve; 41-fixing piece; 411-incision; 42-first capillary; 43-third capillary; 431-spherical chamber; 432-through hole; 5-drug core; 51-first nut; 52-second capillary; 6-protective cap; 61-second nut; 62-plug wire; 621-plug; 63-rotating part; 7-micro drug delivery pump; 71-drug delivery hose. DETAILED DESCRIPTION

[0027] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0028] Multiple experiments require multiple electrode implantations, which causes greater damage to the receptors, high surgical risks, and low surgical efficiency. In addition, the positions of multiple implanted recording electrodes may deviate, resulting in low experimental accuracy.

[0029] In order to solve the above-mentioned problems, a closed-loop electrode for monitoring cerebral cortex and nuclei and micro-dosing is provided below.

[0030] (First embodiment)

[0031] Combination Figure 1 , Figure 2 The EEG signal acquisition electrode includes a signal acquisition component and a micro-dose administration component. Both the signal acquisition component and the micro-dose administration component are fixed on the surface of the skull and penetrate the skull to contact the cerebral cortex.

[0032] The signal acquisition component includes an electrode unit 1, a skull nail 2 and an electrode connector 3. The electrode unit 1 is attached to the surface of the skull, the skull nail 2 penetrates the electrode unit 1 and the skull and is inserted into the cerebral cortex, the electrode connector 3 connects the electrode unit 1 and the recording terminal, and finally the neural units of the cerebral cortex are electrically connected through the skull nail 2, the electrode unit 1 and the recording terminal.

[0033] The micro-dosing component includes a dosing sleeve 4, a dosing inner core 5 and a protective cap 6. The dosing sleeve 4 is implanted into the dosing site of the brain area through the skull. The dosing inner core 5 is connected to a micro-dosing pump 7 through a dosing hose 71. The micro-dosing pump 7 is used to output the drug solution to achieve dosing. The dosing inner core 5 and the protective cap 6 are both detachably connected to the dosing sleeve 4. When the dosing inner core 5 is separated from the dosing sleeve 4, the protective cap 6 is connected to the dosing sleeve 4 to achieve the purpose of sealing the dosing sleeve 4.

[0034] Combination Figure 3 Regarding the structure of the electrode unit 1, Figure 2 The electrode unit 1 includes: a base layer 11 and a conductive layer 12, the base layer 11 is used to wrap the conductive layer 12 to provide mechanical support, flexibility and insulation for the conductive layer 12, and the conductive layer 12 is used to electrically connect the skull nail 2 and the electrode connector 3.

[0035] At least one conductive layer 12 is formed inside the base layer 11, and each conductive layer 12 includes a plurality of circuits 121. One end of the circuit 121 is connected to the electrode connector 3, and the other end of the circuit 121 is connected to the conductive contact 122. The conductive contacts 122 are evenly and densely distributed according to the shape of the skull.

[0036] A mounting hole 111 is formed at a position of the base layer 11 corresponding to the conductive contact 122, and the conductive contact 122 is exposed inside the mounting hole 111. The mounting hole 111 allows the skull nail 2 to pass through the base layer 11 to fix the connection between the skull and the electrode unit 1, and ensures effective contact between the skull nail 2 and the conductive contact 122, so that the conductive contact 122 can directly obtain EEG signals through the skull nail 2.

[0037] The electrode connector 3 is connected to each conductive contact 122 through the circuit 121 in the electrode unit 1. The electrode connector 3 is used to transmit the EEG signal collected by each skull nail 2 to an external signal amplification, processing and recording terminal to ensure the integrity and reliability of the signal.

[0038] Regarding the material of the electrode unit 1.

[0039] The base layer 11 is made of a biocompatible flexible film material, such as polyimide (PI), parylene, polydimethylsiloxane (PDMS), polyurethane (PU), silicone or silicone rubber.

[0040] The circuit 121 is made of non-absorbable conductive materials, such as gold, silver, carbon nanotubes, etc. The circuit 121 can also be made of absorbable conductive materials, such as magnesium and magnesium alloys. The circuit 121 is formed by wiring, etching, sputtering, printing, printing, etc.

[0041] The skull nail 2 is made of a biocompatible conductive material, such as stainless steel, titanium or titanium alloy, gold, carbon, silver / silver chloride, etc.

[0042] Combination Figure 2 Regarding the structure of the drug delivery cannula 4, the drug delivery cannula 4 includes a fixing part 41 and a first capillary 42. The fixing part 41 has an external thread. The fixing part 41 is fixed to the skull by a biocompatible glue such as dental cement. The fixing part 41 and the first capillary 42 are integrated. The fixing part 41 is used to provide stable support for the first capillary 42. The first capillary 42 is implanted into the target brain area. The first capillary 42 is used to accurately deliver drugs. The implantation process of the first capillary 42 includes: opening a hole in the skull by a skull drill, clamping the fixing part 41 with a clamp on a brain stereotaxic instrument, positioning it in the drug delivery brain area, and driving the first capillary 42 to the brain area of ​​corresponding depth through the brain stereotaxic Z axis.

[0043] As for the material of the drug delivery sleeve 4 , the fixing member 41 may be made of titanium, titanium alloy and stainless steel, and the first capillary tube 42 may be made of stainless steel.

[0044] Combination Figure 1 , Figure 2Regarding the structure of the drug-delivering core 5, the drug-delivering core 5 includes a first nut 51 and a second capillary 52. ​​The first nut 51 has an internal thread, and the first nut 51 can be threadedly connected to the fixing piece 41. The second capillary 52 is integrated with the first nut 51. One end of the second capillary 52 is connected to the drug-delivering hose 71. When the first nut 51 is tightened on the fixing piece 41, the other end of the second capillary 52 is connected to the first capillary 42 to form a continuous drug-delivering channel. Specifically, the first capillary 42 serves as a guide tube for the second capillary 52, and the second capillary 52 moves along the inner wall of the first capillary 42 to the drug-delivering area.

[0045] As for the material of the drug delivery core 5 , the first nut 51 can be made of titanium, titanium alloy and stainless steel, and the second capillary 52 can be made of stainless steel.

[0046] Combination Figure 2 Regarding the structure of the protective cap 6, the protective cap 6 includes a second nut 61 and a blocking wire 62. The second nut 61 has an internal thread. The second nut 61 can be threadedly connected to the fixing piece 41. The blocking wire 62 and the second nut 61 form a whole. When the first nut 51 is separated from the fixing piece 41, the second nut 61 can be screwed onto the fixing piece 41 to prevent animals from gnawing and contaminating it during long-term burial. At this time, the blocking wire 62 is inserted into the first capillary 42, thereby preventing the body fluid inside the skull from entering the first capillary 42 to avoid internal blockage of the first capillary 42.

[0047] As for the material of the protection cap 6 , the second nut 61 can be made of titanium, titanium alloy and stainless steel, and the plugging wire 62 can be made of stainless steel.

[0048] The following provides specific application methods of EEG signal acquisition electrodes.

[0049] S1, install electrode unit 1.

[0050] S11, Preparation: Cut the skin on the head of the experimental subject (such as a mouse), clean the mucous membrane on the surface of the skull, and expose the skull.

[0051] S12, positioning: positioning the electrode unit 1 on the skull surface and marking the position of the conductive contact 122.

[0052] S13, drilling: using a skull drill, drill holes of appropriate sizes at the mounting holes 111 corresponding to the conductive contacts 122 and at the embedding holes 112 corresponding to the fixing members 41.

[0053] S13, installation: reattach the electrode unit 1 to the skull surface, and ensure that the installation hole 111 and the embedding hole 112 are aligned with the drilled hole.

[0054] S14, fixation: sequentially pass the corresponding skull nails 2 through the mounting holes 111 and drill holes and screw them into the skull, fix the electrode unit 1 tightly to the skull, ensure that the skull nails 2 are in close contact with the conductive contacts 122, and the EEG signals are transmitted to the circuit 121 in the electrode unit 1 through the skull nails 2, and then transmitted to the electrode connector 3, and finally transmitted to the recording terminal at the rear end.

[0055] S2, install the microdosing assembly.

[0056] S21 , positioning: implanting the fixing member 41 and the first capillary 42 into the embedding hole 112 .

[0057] S22, fixation: implant the drug delivery cannula 4 into a specific brain region using a clamp, and fix the fixture 41 on the skull using a biocompatible glue (such as dental cement).

[0058] S23, connection: screw on the first nut 51 to connect the second capillary 52 with the first capillary 42 to form a complete drug delivery channel.

[0059] S24, drug administration: connect the drug administration hose 71 and connect it to the micro-dosing pump 7 to deliver the drug.

[0060] S3, protective measures.

[0061] S31, packaging: use biocompatible glue to seal and fix the electrode unit 1 and the drug delivery sleeve 4, leaving only the electrode connector 3 and the fixing part 41 exposed to the outside, to prevent the recipient's body fluid from contacting the conductive contact 122, avoid corrosion and affect the signal quality.

[0062] S31, long-term maintenance: when no medication is given for a long time, remove the first nut 51, screw on the second nut 61, and insert the blocking wire 62 into the first capillary 42 to prevent body fluids from entering and clogging, and to prevent the subject from biting or contaminating.

[0063] (Second embodiment)

[0064] Since the protective cap 6 needs to be removed when administering the drug, it is often difficult to find the protective cap 6 after the experiment, and the blocking wire 62 of the protective cap 6 is exposed to the outside. The blocking wire 62 is easily contaminated by bacteria in the air. Inserting the blocking wire 62 into the third capillary 43 may cause infection of the recipient. In order to solve this problem, an improved micro-dosing component is provided below.

[0065] Combination Figure 4 and Figure 5 The micro-dosing assembly of the second embodiment is different from that of the first embodiment in that:

[0066] The drug delivery sleeve 4 includes a fixing member 41 and a third capillary 43 . One end of the third capillary 43 is implanted in the target brain region, and the other end of the third capillary 43 extends to the top of the fixing member 41 and is used to connect to the second capillary 52 .

[0067] A spherical chamber 431 with a larger diameter than the third capillary 43 is formed in the middle of the third capillary 43 . A through hole 432 is provided in the spherical chamber 431 at a position deviating from the axis of the third capillary 43 . The blocking wire 62 can be inserted into the third capillary 43 through the through hole 432 .

[0068] The end of the blocking wire 62 is connected to a plug 621, which is a sphere or a cylinder with a diameter larger than that of the blocking wire 62. The diameter of the plug 621 is the same as the diameter of the third capillary 43. The diameter of the through hole 432 is larger than the diameter of the blocking wire 62 and smaller than the diameter of the plug 621, so that the blocking wire 62 can pass through the through hole 432 but the plug 621 cannot. The plug 621 is used to complete the operation of closing the third capillary 43.

[0069] A cutout 411 is formed on one side of the upper half of the fixing member 41 , and the cutout 411 starts from the top surface of the fixing member 41 and extends downward along the axial direction of the fixing member 41 to the through hole 432 of the spherical chamber 431 , so that the through hole 432 of the spherical chamber 431 is exposed to the outside of the fixing member 41 .

[0070] One end of the blocking wire 62 connected to the second nut 61 is connected to a rotating member 63, which is in the shape of a disc that can rotate around the second nut 61. The blocking wire 62 is eccentrically connected to the rotating member 63 so that when the second nut 61 is screwed onto the fixing member 41, the blocking wire 62 can always be located inside the incision 411.

[0071] The specific application of the second embodiment is provided below.

[0072] Prepare for drug administration: unscrew the second nut 61, and the plugging wire 62 is withdrawn from the third capillary 43, and the plug 621 remains in the spherical chamber 431 to block the through hole 432 to prevent body fluids from entering and contaminating.

[0073] Drug administration: Tighten the first nut 51 and the fixing part 41, connect the second capillary 52 to the third capillary 43, and establish a drug administration pathway. Specifically, the third capillary 43 serves as a guide tube for the second capillary 52, and the second capillary 52 moves along the inner wall of the third capillary 43 to the drug administration area, and then the drug solution is transported to the target brain area through the drug administration hose 71, the second capillary 52 and the third capillary 43 by the micro-dosing pump 7. At this time, the second nut 61 is always connected to the side of the fixing part 41 through the rotating part 63, the blocking wire 62 and the plug 621, and will not be lost. The plug 621 is always located inside the spherical chamber 431 and will not be contaminated by bacteria in the air.

[0074] End of drug administration: After drug administration is completed, unscrew the first nut 51 to disconnect the drug administration passage, tighten the second nut 61, reinsert the plugging wire 62 into the third capillary 43, and move the plug 621 out of the spherical chamber 431 and into the third capillary 43 to block the pipeline to prevent leakage or contamination of body fluids.

[0075] The above embodiments are only exemplary embodiments of the present invention and are not intended to limit the present invention. The protection scope of the present invention is defined by the claims. Those skilled in the art may make various modifications or equivalent substitutions to the present invention within the essence and protection scope of the present invention, and such modifications or equivalent substitutions shall also be deemed to fall within the protection scope of the present invention.

Claims

1. A closed-loop electrode for monitoring cerebral cortex and nuclei and micro-dosing, characterized in that: It includes a signal collection component and a micro-dosing component, wherein the signal collection component and the micro-dosing component are both fixed to the surface of the skull and penetrate the skull to contact the cerebral cortex; The signal acquisition assembly includes an electrode unit, a skull nail and an electrode connector, wherein the electrode unit is attached to the surface of the skull, the skull nail penetrates the electrode unit and the skull and is inserted into the cerebral cortex, and the electrode connector connects the electrode unit and the recording terminal; The micro-dosing assembly comprises a dosing sleeve, a dosing inner core and a protective cap. The dosing sleeve is implanted into a dosing site in the brain region through the skull. The dosing inner core and the protective cap are both detachably connected to the dosing sleeve. The dosing sleeve is used to guide the dosing inner core to pass through itself to reach the dosing site. The protective cap is used to connect the dosing sleeve to seal the dosing sleeve. The drug delivery sleeve comprises a fixing member and a third capillary tube, one end of the third capillary tube is implanted in the target brain region, the other end of the third capillary tube extends to the top of the fixing member, a spherical chamber with a diameter larger than the third capillary tube is formed in the middle of the third capillary tube, a through hole is provided at a position of the spherical chamber deviating from the axis of the third capillary tube, a cutout is formed on one side of the upper half of the fixing member, the cutout starts from the top surface of the fixing member and extends downward along the axis direction of the fixing member to the through hole, so that the through hole is exposed outside the fixing member; The protective cap includes a second nut and a plugging wire. The second nut can be threadedly connected to the fixing member. The plugging wire and the second nut form an integral body. A plug is connected to the end of the plugging wire. The plug is a sphere or a cylinder with a diameter larger than the plugging wire. The diameter of the plug is the same as the diameter of the third capillary. The diameter of the through hole is larger than the diameter of the plugging wire and smaller than the diameter of the plug, so that the plugging wire can pass through the through hole but the plug cannot pass through the through hole. The plug is used to be inserted into the third capillary to prevent body fluids inside the skull from entering the third capillary. One end of the plugging wire connected to the second nut is connected to a rotating part. The rotating part is a disc shape that can rotate around the second nut. The plugging wire is eccentrically connected to the rotating part so that when the second nut is screwed on the fixing member, the plugging wire can always be located inside the incision.

2. A closed-loop electrode for monitoring cerebral cortex and nuclei and micro-dosing according to claim 1, characterized in that: The electrode unit includes: a base layer and a conductive layer, wherein the base layer is used to wrap the conductive layer, the base layer has flexibility and insulation, and the conductive layer is used to electrically connect the skull nail and the electrode connector.

3. A closed-loop electrode for monitoring cerebral cortex and nuclei and micro-dosing according to claim 2, characterized in that: A plurality of conductive contacts are installed inside the base layer. The conductive contacts are evenly and densely distributed according to the shape of the skull. The conductive layer includes a plurality of circuits, and the electrode connector is connected to each of the conductive contacts through the circuits.

4. A closed-loop electrode for monitoring cerebral cortex and nuclei and micro-dosing according to claim 3, characterized in that: The base layer is formed with a mounting hole at a position corresponding to the conductive contact, and the conductive contact is exposed inside the mounting hole. The mounting hole allows the skull nail to pass through the base layer to fix the connection between the skull and the electrode unit and ensure effective contact between the skull nail and the conductive contact.

5. A closed-loop electrode for monitoring cerebral cortex and nuclei and micro-dosing according to claim 3, characterized in that: The base layer is made of a flexible film material with biocompatibility, the circuit is made of a non-absorbable conductive material, and the skull nail is made of a conductive material with biocompatibility.

6. A closed-loop electrode for monitoring cerebral cortex and nuclei and micro-dosing according to claim 1, characterized in that: The drug delivery inner core includes a first nut and a second capillary, wherein the first nut can be threadably connected to the fixing member, and the second capillary is integrated with the first nut. When the first nut is tightened on the fixing member, the second capillary passes through the third capillary to reach the drug delivery site.

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