An intelligent thromboelastograph precise temperature control system based on cloud platform technology

Abstract

The present invention discloses a precise temperature control system for an intelligent thromboelastograph based on cloud platform technology. The precise temperature data is determined by temperature acquisition and temperature verification. The data such as the angle and speed of the liquid rotating in the test cup when the instrument is running are combined. The cloud platform is used to collect and analyze the data. The optimal heating method that can reach the target temperature is obtained by iterative optimization combined with the improved Parrot optimization algorithm. The heating angle and heating power are changed according to the rotation angle and rotation speed of the liquid, so that the liquid temperature is highly close to the target temperature, and the system can accurately control the liquid temperature. At the same time, the temperature acquisition transmits the temperature data to the cloud platform in real time, and the system can control the liquid temperature in real time. Compared with the prior art, the present invention can realize high-precision control of the liquid temperature by the temperature control system of the thromboelastograph.

Description

Technical Field

[0001] The present invention relates to a precise temperature control system for an intelligent thromboelastograph based on cloud platform technology, and belongs to the field of cloud computing. Background Art

[0002] Thrombelastograph is a non-invasive diagnostic instrument used to monitor and analyze the coagulation state of blood samples. The number of thromboelastographs in use nationwide is huge, and with the improvement of diagnosis and treatment and blood transfusion requirements, its application areas are still expanding, the market procurement volume is increasing year by year, and its calibration demand is also exploding geometrically. The accuracy of the test results of thromboelastograph is related to the lives of many patients. It can be applied to the metrological standardization and metrological service of thromboelastograph, and can be promoted to national metrological institutions or third-party testing institutions for metrological testing of thromboelastographs, improve the metrological guarantee service capabilities and market supervision capabilities in the medical field, and fill the gap in temperature calibration devices dedicated to thromboelastographs.

[0003] Thromboelastography is divided into two processes: coagulation and fibrinolysis. The key parameters in the two processes include: coagulation time (R), coagulation rate (K), angle between tangent and horizontal (Angle), and maximum amplitude (MA). The liquid temperature has the greatest impact on the four key parameters. When the thromboelastograph is working, the liquid in the test cup needs to rotate at a specific angle and rate, which makes it difficult to collect accurate liquid temperature and cannot ensure that the liquid temperature is always maintained at the target temperature, thus affecting the accuracy of the thromboelastograph test results, directly affecting the diagnosis and treatment results and the amount of blood products used. At present, there is a lack of corresponding temperature measurement and temperature control technology. Summary of the invention

[0004] Purpose of the invention: In response to the problems in the background technology, the present invention discloses a precise temperature control system for an intelligent thromboelastograph based on cloud platform technology. The system utilizes cloud platform technology to make corresponding changes in the heating angle and heating power according to the specific rotation angle and rotation rate of the liquid in the test cup when the instrument is running, so that the liquid is highly close to the set target temperature after heating, thereby achieving high-precision control of the liquid temperature by the thromboelastograph temperature control system.

[0005] Technical solution: The present invention discloses a precise temperature control system for an intelligent thromboelastograph based on cloud platform technology, comprising a data acquisition module, a temperature calibration module, a heating module and a cloud platform module;

[0006] The temperature data acquisition module acquires the heating temperature, the air temperature in the cup, and the liquid temperature in the cup;

[0007] The temperature verification module is connected to the temperature data acquisition module, and ensures that the liquid temperature is always maintained at the target temperature according to the temperature data collected in real time. When there is a certain difference between the liquid temperature and the target temperature, feedback is sent to the cloud platform module;

[0008] The cloud platform module is provided with a relationship model between the actual temperature of the liquid in the test cup and the air temperature, the heating temperature, the rotation angle and the rotation rate of the liquid. The optimal heating method that can achieve the target temperature is obtained by combining the Parrot Optimization Algorithm PO iterative optimization, and the heating method is fed back to the heating module; the real-time temperature data is transmitted to the cloud platform module by using the temperature data acquisition module, so that the system can realize real-time and precise control of the liquid temperature;

[0009] The heating module collects the rotation angle and rotation rate of the liquid in the test cup when the instrument is running, and changes the heating angle and heating power of the test cup so that the liquid is highly close to the set target temperature after heating, thereby realizing high-precision control of the liquid temperature by the temperature control system of the thromboelastography instrument;

[0010] The relationship model between the actual temperature of the liquid in the test cup and the air temperature, heating temperature, liquid rotation angle and rotation rate is:

[0011] O=(A+B+C)T

[0012] Wherein, O is the actual temperature of the liquid in the cup, A is the influence coefficient of the air temperature in the thromboelastograph measuring cup on the liquid temperature, B is the influence coefficient of the heating temperature of the thromboelastograph on the liquid temperature, C is the influence coefficient of the rotation angle and rotation rate of the liquid in the test cup when the thromboelastograph is running on the liquid temperature, and T is the liquid temperature.

[0013] Furthermore, the influence coefficient of the air temperature on the liquid temperature in the thromboelastograph measuring cup is specifically:

[0014] A=αQ a

[0015] Q a =m·c·ΔT

[0016] Where α is the convective heat transfer coefficient, which indicates the amount of heat transferred per unit area per unit time. α depends on the properties of the fluid, flow rate, temperature difference, and surface geometry. Q a is the heat flow transfer, m is the mass of the liquid, c is the specific heat capacity of the liquid, and ΔT is the temperature difference between the liquid and the air.

[0017] Furthermore, the influence coefficient of the heating temperature of the thromboelastography instrument on the liquid temperature is:

[0018] B=β(Q in -Q out )

[0019] Q in =ηPt

[0020] Qout = k·ΔT

[0021] Where β is the thermal conductivity, Q in is the amount of heat entering the liquid per unit time, which is increased by the heating element, η is the heating efficiency of the heating element, P is the heating power of the heating element, t is the heating time, Q out is the amount of heat dissipated from the liquid through the container wall and liquid surface per unit time, k is a constant related to the properties of the liquid and container, and ΔT is the temperature difference between the liquid and the air.

[0022] Furthermore, when the thromboelastograph is running, the influence coefficient of the rotation angle and rotation rate of the liquid in the test cup on the liquid temperature is:

[0023] C=ωQ in

[0024] Q in =ηPt

[0025] Where ω is the enhancement factor caused by rotation, which depends on the rotation angle and rotation rate of the liquid, Q in is the amount of heat entering the liquid per unit time and increased by the heating element, η is the heating efficiency of the heating element, P is the heating power of the heating element, and t is the heating time.

[0026] Furthermore, the system also includes a human-computer interaction module, which includes a temperature display module, a temperature setting module and an abnormal alarm module, which is used to display the real-time temperature of the liquid and issue an abnormal alarm when the temperature exceeds the normal range; the temperature setting module can manually set the temperature and set the target temperature in the cloud platform module.

[0027] Furthermore, it also includes a safety protection module, which is interconnected with the heating module and includes overheat protection, short circuit protection, power supply filtering, voltage stabilization and overcurrent and overvoltage protection, so as to provide real-time safety protection for the heating module.

[0028] Furthermore, the temperature data acquisition module includes a temperature sensor for collecting the heating temperature and the air temperature in the cup, and a high-precision temperature sensor for collecting the liquid temperature in the cup; the high-precision temperature sensor utilizes the test cup cover to connect the suspension wire, and directly penetrates into the test cup from above to measure the temperature. The high-precision temperature sensor is equipped with an electromagnetic sensor and uses Bluetooth communication technology to realize wireless data transmission in the thromboelastography test cup.

[0029] Furthermore, the Parrot Optimization Algorithm PO is combined with iterative optimization to obtain the optimal heating method that can reach the target temperature, and the heating method is fed back to the heating module, including the following steps:.

[0030] Step 1: Initialization phase; the population size is N, the maximum number of iterations is maxiter, and its mathematical expression is as follows:

[0031] O i =lb+rand(0,1)·(ub-lb)

[0032] Where lb and ub are the lower and upper bounds of the exploration space, rand(0,1) is a random number in the range [0,1], and O i is the position of the i-th parrot at the initial stage;

[0033] Step 2: Foraging stage: The parrot estimates the approximate location of the food by observing the location of the food or considering the location of the owner, and then flies to their respective locations, that is, the liquid temperature continues to approach the target temperature. The mathematical expression is as follows:

[0034]

[0035] In the formula, is the current position of the parrot, that is, the current temperature of the liquid in the test cup, The position updated by the parrot later is the liquid temperature that is closer to the target temperature. is the average position within the current population, i.e. the middle value of the liquid temperature range, O best is the best position searched from initialization to now, which also represents the current position of the owner, that is, the liquid temperature closest to the target temperature. t is the current iteration number. Levy (D) represents the Levy distribution, which is used to describe the flight situation of the parrot. It means that it moves according to its relative position to the owner, that is, the liquid temperature keeps approaching the target temperature. It means observing the position of the entire population to further determine the direction of food;

[0036]

[0037] In the formula, γ is assigned a value of 1.5; μ and ν are random variables used to describe the parrot's flight conditions, both of which obey normal distribution. σ is related to the dispersion of Levy distribution and controls the range of Levy distribution. σ is a fixed value.

[0038] Step 3: Staying stage: The parrot suddenly flies to any part of the owner's body and stays still for a period of time. The mathematical expression is as follows:

[0039]

[0040] In the formula, ones(1,dim) is a vector of all 1s of dimension dim, O bestLevy(dim) represents the process of the parrot flying towards the owner, that is, the process of the liquid temperature approaching the target temperature, rand(0,1)·ones(1,dim) represents the process of the parrot randomly stopping at a certain part of the owner's body;

[0041] Step 4: Communication stage; communication behaviors include flying toward the flock and not flying toward the flock. In PO, it is assumed that the probability of these two behaviors is equal, and the average position of the current population is used to symbolize the center of the group, indicating that within a certain error range, the current heating method is maintained to make the liquid temperature close to the target temperature. If it exceeds a certain error range, the heating method is changed to make the liquid temperature close to the target temperature. The mathematical expression is as follows:

[0042]

[0043] In the formula, It indicates the process of individuals joining the parrot group to communicate, that is, the error between the liquid temperature and the target temperature is small, and the current heating method is continued to make the liquid temperature approach the target temperature. It represents the process in which the individual flies out immediately after the communication, that is, the error between the liquid temperature and the target temperature is large. The heating method is changed to make the liquid temperature close to the target temperature. Both behaviors are feasible. Therefore, P randomly generated in the range of [0,1] is used to achieve this;

[0044] Step 5: Fear stage: The parrot keeps a distance from unfamiliar individuals and seeks a safe environment with its owner, that is, to find the optimal solution for the liquid temperature closest to the target temperature. The mathematical expression is as follows:

[0045]

[0046] In the formula, Indicates the process of redirecting the flight towards the owner. It means the process of moving away from strangers;

[0047] The final output That is, the actual temperature of the liquid that is closest to the target temperature, while outputting the best heating power, heating angle and heating time.

[0048] Beneficial effects:

[0049] 1. Compared with the traditional thromboelastograph, the present invention uses cloud platform technology to make corresponding changes in heating angle and heating power according to the specific rotation angle and rotation rate of the liquid in the test cup when the instrument is running, so that the liquid is highly close to the set target temperature after heating, thereby realizing high-precision control of the liquid temperature by the thromboelastograph temperature control system.

[0050] 2. Compared with the traditional thromboelastograph, the test cup cover is connected to the hanging wire, and the temperature is measured directly from the top of the test cup. The high-precision temperature sensor is equipped with an electromagnetic sensor, and Bluetooth communication technology is used to achieve wireless data transmission in the test cup of the thromboelastograph, avoiding temperature measurement errors caused by the liquid in the test cup rotating at a specific angle and rate when the instrument is running, achieving accurate collection of liquid temperature data and improving the accuracy of system data.

[0051] 3. The present invention determines accurate temperature data through temperature acquisition and temperature verification, combines the angle and speed of the liquid rotation in the test cup when the instrument is running, uses the cloud platform to collect and analyze the data, combines the improved Parrot Optimization Algorithm (PO) iterative optimization to obtain the optimal heating method that can reach the target temperature, changes the heating angle and heating power according to the rotation angle and rotation speed of the liquid, makes the liquid temperature highly close to the target temperature, realizes the system's accurate control of the liquid temperature, and at the same time, the temperature acquisition transmits the temperature data to the cloud platform in real time, realizes the system's real-time control of the liquid temperature. Realizing high-precision control of the liquid temperature by the temperature control system of the thromboelastograph can effectively improve the reliability and stability of the thromboelastograph.

[0052] 4. The present invention realizes efficient and precise control of the precise temperature control system of the intelligent thromboelastography instrument by adopting the improved parrot optimization algorithm (PO). The advantage of this algorithm is that it simulates the foraging, staying, communication and fear behaviors of parrots, and accurately adjusts the heating method by iteratively optimizing the objective function, that is, measuring the actual temperature of the liquid in the cup, so as to achieve a high degree of closeness between the liquid temperature and the set target temperature. The design of the objective function of the present invention fully considers the comprehensive influence of air temperature, heating temperature, liquid rotation angle and rate on liquid temperature, as well as factors such as convective heat transfer coefficient, heat flow, liquid mass, specific heat capacity and temperature difference, to ensure the accuracy and stability of temperature control. Compared with traditional temperature control systems, this technology not only improves the heating efficiency and accuracy through algorithm optimization, but also enhances the adaptability and intelligence level of the system, so that it has significant competitive advantages among similar products, especially in the control accuracy of the heating target, and can provide users with more reliable and accurate temperature control solutions. BRIEF DESCRIPTION OF THE DRAWINGS

[0053] Figure 1 It is a structural block diagram of the system equipment of the present invention;

[0054] Figure 2 It is the algorithm flow chart of the present invention;

[0055] Figure 3 It is a connection circuit diagram of the high-precision temperature sensor of the present invention;

[0056] Figure 4This is a comparison chart of temperature errors before and after optimization;

[0057] Figure 5 This is a comparison chart of heating efficiency before and after optimization. DETAILED DESCRIPTION

[0058] The present invention will be further described below in conjunction with the accompanying drawings. The following embodiments are only used to more clearly illustrate the technical solutions of the present invention and are not intended to limit the protection scope of the present invention.

[0059] See also Figure 1 The present invention discloses an intelligent thromboelastograph precise temperature control system based on cloud platform technology, which mainly includes a temperature data acquisition module, a temperature verification module, a human-computer interaction module, a heating module, a safety protection module and a cloud platform module.

[0060] The temperature data acquisition module and the temperature verification module are interconnected. By exchanging temperature acquisition data and temperature verification data, accurate temperature data is obtained and transmitted to the cloud platform module. The heating module transmits data such as the rotation angle and rotation rate of the liquid in the test cup when the instrument is running to the cloud platform module in real time. The cloud platform module collects and analyzes the data, and combines the improved Parrot Optimization Algorithm (PO) to iteratively optimize and obtain the optimal heating method that can achieve the target temperature. The heating method is fed back to the heating module, and the temperature data acquisition module is used to transmit the real-time temperature data to the cloud platform module, so that the system can accurately control the liquid temperature in real time. The human-computer interaction module displays the real-time temperature of the liquid, and issues an abnormal alarm when the temperature exceeds the normal range, which improves the safety of the system operation. The human-computer interaction module can also manually set the temperature to meet the temperature requirements in specific situations. The safety protection module is interconnected with the heating module, and the heating module is protected in real time to ensure the safety and stability of the system during operation.

[0061] The temperature data acquisition module mainly includes a temperature sensor for collecting the heating temperature and the air temperature in the cup, and a high-precision temperature sensor for collecting the temperature of the liquid in the cup. The high-precision temperature sensor uses the test cup cover to connect the hanging wire, and directly penetrates the test cup from the top of the test cup to measure the temperature. The high-precision temperature sensor is equipped with an electromagnetic sensor and uses Bluetooth communication technology to achieve wireless data transmission in the thromboelastograph test cup, avoiding temperature measurement errors caused by the liquid in the test cup rotating at a specific angle and rate when the instrument is running, achieving accurate collection of liquid temperature data and improving the accuracy of system data. For the circuit connection diagram of the high-precision temperature sensor, see Figure 3 .

[0062] The temperature calibration module includes a calibration module, calibration result management and user management. The calibration module includes a device setting module, a calibration adjustment setting module and a real-time display curve module. The calibration result management includes calibration result viewing, calibration result saving, calibration result importing and calibration original record generation. User management includes user viewing, permission setting and role management. Based on the temperature data collected in real time by the temperature data acquisition module, ensure that the liquid temperature is always maintained at the target temperature. When there is a certain difference between the liquid temperature and the target temperature, feedback is sent to the cloud platform module.

[0063] The human-computer interaction module mainly includes a temperature display module, a temperature setting module and an abnormal alarm module. The human-computer interaction module sets the temperature of the system manually to meet the temperature requirements under specific circumstances. At the same time, the human-computer interaction module displays the real-time temperature of the liquid and issues an abnormal alarm when the temperature exceeds the normal range, thereby improving the safety of system operation.

[0064] The heating module uses cloud platform technology to test the specific rotation angle and rotation rate of the liquid in the cup when the instrument is running, and makes corresponding changes to the heating angle and heating power, so that the liquid is highly close to the set target temperature after heating, thereby achieving high-precision control of the liquid temperature by the thromboelastography temperature control system.

[0065] The safety protection module is interconnected with the heating module to provide real-time safety protection for the heating module, mainly including overheat protection, short circuit protection, power supply filtering, voltage stabilization, and overcurrent and overvoltage protection. Among them, overheat protection prevents the equipment from being damaged or causing a fire due to excessive internal temperature; short circuit protection prevents short circuit faults caused by electrical short circuit of conductors with unequal potentials in the power supply system; power supply filtering is mainly used to eliminate noise and interference in the power supply to ensure the purity and stability of the power supply output signal; voltage stabilization is to ensure the stability of the power supply output voltage; overcurrent and overvoltage protection is to prevent the power supply output current or voltage from exceeding the preset safety threshold. The safety protection module ensures the stable operation of the system and improves data reliability.

[0066] The cloud platform module obtains accurate temperature data by combining the temperature data acquisition module with the temperature verification module. It is equipped with a relationship model between the actual temperature of the liquid in the test cup and the air temperature, heating temperature, liquid rotation angle and rotation rate. It is combined with the Parrot Optimization Algorithm PO iterative optimization to obtain the optimal heating method that can reach the target temperature, and the heating method is fed back to the heating module; the temperature data acquisition module is used to transmit the real-time temperature data to the cloud platform module, so that the system can accurately control the liquid temperature in real time. The cloud platform module is also connected to the human-computer interaction module. The cloud platform module transmits the temperature data to the human-computer interaction module in real time and displays it. The human-computer interaction module can input the target temperature into the cloud platform module through temperature settings.

[0067] After heating, the liquid temperature is very close to the target temperature. The improved Parrot Optimization Algorithm (PO) is used for control, which mainly includes the following steps:

[0068] The optimal control mode of high-precision temperature control is obtained by optimizing the objective function through an algorithm. The objective function is the actual temperature of the liquid in the measuring cup.

[0069] O=(A+B+C)T

[0070] Wherein, A is the influence coefficient of the air temperature in the measuring cup of the thromboelastograph on the liquid temperature, B is the influence coefficient of the heating temperature of the thromboelastograph on the liquid temperature, C is the influence coefficient of the rotation angle and rotation rate of the liquid in the test cup when the thromboelastograph is running on the liquid temperature, and T is the liquid temperature.

[0071] A=αQ a

[0072] Q a =m·c·ΔT

[0073] Where α is the convective heat transfer coefficient, which indicates the amount of heat transferred per unit area per unit time. α depends on factors such as the properties of the fluid, flow rate, temperature difference, and surface geometry. Q a is the heat flow transfer, m is the mass of the liquid, c is the specific heat capacity of the liquid, and ΔT is the temperature difference between the liquid and the air.

[0074] B=β(Q in -Q out )

[0075] Q in =ηPt

[0076] Q out = k·ΔT

[0077] Where β is the thermal conductivity, Q in is the heat entering the liquid per unit time (increased by the heating element), η is the heating efficiency of the heating element, P is the heating power of the heating element, t is the heating time, Q out is the amount of heat lost from the liquid per unit time (through the container wall, liquid surface, etc.), k is a constant related to the properties of the liquid and container, and ΔT is the temperature difference between the liquid and the air.

[0078] C=ωQ in

[0079] Where ω is the enhancement factor caused by rotation, which depends on the rotation angle and rotation rate of the liquid.

[0080] The optimization process of Parrot Optimization Algorithm (PO) is as follows:

[0081] Step 1: Initialization phase. The population size is N, the maximum number of iterations is maxiter, and its mathematical expression is as follows:

[0082] O i =lb+rand(0,1)·(ub-lb)

[0083] Where lb and ub are the lower and upper bounds of the exploration space, rand(0,1) is a random number in the range [0,1], and O i is the position of the i-th parrot in the initial stage.

[0084] Step 2: Foraging stage. The parrot estimates the approximate location of the food by observing the location of the food or considering the location of the owner, and then flies to their respective locations, that is, the liquid temperature continues to approach the target temperature. Its mathematical expression is as follows:

[0085]

[0086] In the formula, is the current position of the parrot, that is, the current temperature of the liquid in the test cup, The position updated by the parrot later is the liquid temperature that is closer to the target temperature. is the average position within the current population, i.e. the middle value of the liquid temperature range, O best is the best position searched from initialization to now, which also represents the current position of the owner, that is, the liquid temperature closest to the target temperature. t is the current iteration number. Levy (D) represents the Levy distribution, which is used to describe the flight situation of the parrot. It means that it moves according to its relative position to the owner, that is, the liquid temperature keeps approaching the target temperature. It means observing the position of the entire population to further determine the direction of the food.

[0087]

[0088] In the formula, γ is assigned a value of 1.5; μ and ν are random variables used to describe the flight conditions of the parrot, both of which obey the normal distribution. σ is related to the dispersion of the Levy distribution and controls the range of the Levy distribution. σ is a fixed value.

[0089] Step 3: Staying stage. The parrot suddenly flies to any part of the owner's body and stays still for a while. The mathematical expression is as follows:

[0090]

[0091] In the formula, ones(1,dim) is a vector of all 1s of dimension dim, O bestLevy(dim) represents the process of the parrot flying towards the owner, that is, the process of the liquid temperature approaching the target temperature, and rand(0,1)·ones(1,dim) represents the process of the parrot randomly stopping at a certain part of the owner's body.

[0092] Step 4: Communication phase. Communication behaviors include flying toward the flock and not flying toward the flock. In PO, it is assumed that the probability of these two behaviors is equal, and the average position of the current population is used to symbolize the center of the group. In this algorithm, within a certain error range, the current heating method is maintained to make the liquid temperature close to the target temperature. If the error range is exceeded, the heating method is changed to make the liquid temperature close to the target temperature. The mathematical expression is as follows:

[0093]

[0094] In the formula, It indicates the process of individuals joining the parrot group to communicate, that is, the error between the liquid temperature and the target temperature is small, and the current heating method is continued to make the liquid temperature approach the target temperature. It indicates the process that individuals fly out immediately after communication, that is, the liquid temperature has a large error with the target temperature, and the heating method is changed to make the liquid temperature close to the target temperature. Both behaviors are feasible, so P randomly generated in the range of [0,1] is used to implement them.

[0095] Step 5: Fear stage. The parrot keeps a distance from unfamiliar individuals and seeks a safe environment with its owner, that is, to find the optimal solution for the liquid temperature that is closest to the target temperature. The mathematical expression is as follows:

[0096]

[0097] In the formula, Indicates the process of redirecting the flight towards the owner. It indicates the process of moving away from strangers.

[0098] The final output That is, the actual temperature of the liquid that is closest to the target temperature, while outputting the best heating power, heating angle and heating time.

[0099] The following is an experimental verification of the precise temperature control system of an intelligent thromboelastograph based on cloud platform technology of the present invention. The basic experimental environment of the thromboelastograph needs to meet the requirements of temperature control, humidity control, cleanliness, electromagnetic interference, power supply stability, ventilation system and safety protection to ensure the accuracy and reliability of the experiment. The present invention uses animal whole blood as raw material, such as pig whole blood, cattle whole blood, rabbit whole blood, and sheep whole blood. 5 ml is sampled each time through a precise sampling device, and the sampling time is strictly specified. It is 9:00-10:00 am every day to ensure the consistency of the experimental conditions, and the pre-optimization and post-optimization experiments are carried out.

[0100] In the experiment before optimization, the temperature was controlled by a traditional temperature regulator, that is, the liquid temperature reached the target temperature by combining a wired temperature acquisition device with a traditional temperature control device. The sample was placed in a thromboelastograph for coagulation and fibrinolysis, and the error between the liquid temperature and the target temperature and the heating efficiency of the instrument were recorded when the thromboelastograph was running under different animal whole blood samples. The data showed that the temperature fluctuated widely, the temperature error was between 3% and 5%, and the heating efficiency was about 70%.

[0101] After the optimization experiment, the temperature control introduced the intelligent thromboelastograph precise temperature control system based on cloud platform technology, that is, the test cup cover was connected to the hanging wire, and the temperature was measured directly from the top of the test cup. The high-precision temperature sensor was equipped with an electromagnetic sensor, and Bluetooth communication technology was used to realize wireless data transmission in the test cup of the thromboelastograph. In conjunction with the intelligent thromboelastograph precise temperature control system based on cloud platform technology, the liquid temperature reached the target temperature, and the sample was placed in the thromboelastograph for coagulation and fibrinolysis. The error between the liquid temperature and the target temperature and the heating efficiency of the instrument were recorded when the thromboelastograph was running under different animal whole blood samples. The data showed that the temperature fluctuation range was relatively small, the temperature error was between 0.2% and 0.8%, and the heating efficiency was about 90%.

[0102] It can be seen from the above experiments that the intelligent thromboelastograph precise temperature control system based on cloud platform technology of the present invention can achieve high-precision control of the liquid temperature by the thromboelastograph temperature control system.

[0103] The above embodiments are only for illustrating the technical concept and features of the present invention, and their purpose is to enable people familiar with the technology to understand the content of the present invention and implement it accordingly, and they cannot be used to limit the protection scope of the present invention. Any equivalent transformation or modification made according to the spirit of the present invention should be included in the protection scope of the present invention.

Claims

1. An intelligent thromboelastograph precise temperature control system based on cloud platform technology, characterized in that: It includes temperature data acquisition module, temperature calibration module, heating module and cloud platform module; The temperature data acquisition module acquires the heating temperature, the air temperature in the cup, and the liquid temperature in the cup; The temperature verification module is connected to the temperature data acquisition module, and ensures that the liquid temperature is always maintained at the target temperature according to the temperature data collected in real time. When there is a certain difference between the liquid temperature and the target temperature, feedback is sent to the cloud platform module; The cloud platform module is provided with a relationship model between the actual temperature of the liquid in the test cup and the air temperature, the heating temperature, the rotation angle and the rotation rate of the liquid. The optimal heating method that can achieve the target temperature is obtained by combining the Parrot Optimization Algorithm PO iterative optimization, and the heating method is fed back to the heating module; the real-time temperature data is transmitted to the cloud platform module by using the temperature data acquisition module, so that the system can realize real-time and precise control of the liquid temperature; The heating module collects the rotation angle and rotation rate of the liquid in the test cup when the instrument is running, and changes the heating angle and heating power of the test cup so that the liquid is highly close to the set target temperature after heating, thereby realizing high-precision control of the liquid temperature by the temperature control system of the thromboelastography instrument; The relationship model between the actual temperature of the liquid in the test cup and the air temperature, heating temperature, liquid rotation angle and rotation rate is: O=(A+B+C)T Wherein, O is the actual temperature of the liquid in the cup, A is the influence coefficient of the air temperature in the thromboelastograph measuring cup on the liquid temperature, B is the influence coefficient of the heating temperature of the thromboelastograph on the liquid temperature, C is the influence coefficient of the rotation angle and rotation rate of the liquid in the test cup when the thromboelastograph is running on the liquid temperature, and T is the liquid temperature.

2. According to claim 1, the intelligent thromboelastograph precise temperature control system based on cloud platform technology is characterized in that: The specific coefficient of influence of air temperature on liquid temperature in the thromboelastograph measuring cup is: A=αQ a Q a =m·c·ΔT Where α is the convective heat transfer coefficient, which indicates the amount of heat transferred per unit area per unit time. α depends on the properties of the fluid, flow rate, temperature difference, and surface geometry. Q a is the heat flow transfer, m is the mass of the liquid, c is the specific heat capacity of the liquid, and ΔT is the temperature difference between the liquid and the air.

3. According to the cloud platform technology-based intelligent thromboelastograph precise temperature control system of claim 1, it is characterized in that: The influence coefficient of the heating temperature of the thromboelastography instrument on the liquid temperature is: B=β(Q in -Q out ) Q in =ηPt Q out =k·ΔT Where β is the thermal conductivity, Q in is the amount of heat entering the liquid per unit time, which is increased by the heating element, η is the heating efficiency of the heating element, P is the heating power of the heating element, t is the heating time, Q out is the amount of heat dissipated from the liquid through the container wall and liquid surface per unit time, k is a constant related to the properties of the liquid and container, and ΔT is the temperature difference between the liquid and the air.

4. According to the cloud platform technology-based intelligent thromboelastograph precise temperature control system of claim 1, characterized in that: When the thromboelastograph is running, the influence coefficient of the rotation angle and rotation rate of the liquid in the test cup on the liquid temperature is: C=ωQ in Q in =ηPt Where ω is the enhancement factor caused by rotation, which depends on the rotation angle and rotation rate of the liquid, Q in is the amount of heat entering the liquid per unit time and increased by the heating element, η is the heating efficiency of the heating element, P is the heating power of the heating element, and t is the heating time.

5. According to the cloud platform technology-based intelligent thromboelastograph precise temperature control system of claim 1, it is characterized in that: The system also includes a human-computer interaction module, which includes a temperature display module, a temperature setting module and an abnormal alarm module, which is used to display the real-time temperature of the liquid and issue an abnormal alarm when the temperature exceeds the normal range; the temperature setting module can manually set the temperature and set the target temperature in the cloud platform module.

6. According to claim 1, the intelligent thromboelastograph precise temperature control system based on cloud platform technology is characterized in that: It also includes a safety protection module, which is interconnected with the heating module and includes overheat protection, short circuit protection, power supply filtering, voltage stabilization, and overcurrent and overvoltage protection, so as to provide real-time safety protection for the heating module.

7. According to the cloud platform technology-based intelligent thromboelastograph precise temperature control system of claim 1, it is also characterized in that: The temperature data acquisition module includes a temperature sensor for collecting heating temperature and air temperature in the cup and a high-precision temperature sensor for collecting liquid temperature in the cup; the high-precision temperature sensor utilizes the test cup cover to connect the suspension wire, and directly penetrates into the test cup from above to measure the temperature; the high-precision temperature sensor is equipped with an electromagnetic sensor, and uses Bluetooth communication technology to realize wireless data transmission in the thromboelastography test cup.

8. The intelligent thromboelastograph precise temperature control system based on cloud platform technology according to any one of claims 1 to 7, characterized in that: Combined with the Parrot Optimization Algorithm PO iterative optimization, the optimal heating method that can achieve the target temperature is obtained, and the heating method is fed back to the heating module, including the following steps: Step 1: Initialization phase; the population size is N, the maximum number of iterations is maxiter, and its mathematical expression is as follows: O i =lb+rand(0,1)·(ub-lb) Where lb and ub are the lower and upper bounds of the exploration space, rand(0,1) is a random number in the range [0,1], and O i is the position of the i-th parrot at the initial stage; Step 2: Foraging stage: The parrot estimates the approximate location of the food by observing the location of the food or considering the location of the owner, and then flies to their respective locations, that is, the liquid temperature continues to approach the target temperature. The mathematical expression is as follows: In the formula, is the current position of the parrot, that is, the current temperature of the liquid in the test cup, The position updated by the parrot later is the liquid temperature that is closer to the target temperature. is the average position within the current population, i.e. the middle value of the liquid temperature range, O best is the best position searched so far from the initialization, and also represents the current position of the owner, that is, the liquid temperature closest to the target temperature. t is the current iteration number. Levy() represents the Levy distribution, which is used to describe the flight situation of the parrot. It means that it moves according to its relative position to the owner, that is, the liquid temperature keeps approaching the target temperature. It means observing the position of the entire population to further determine the direction of food; In the formula, γ is assigned a value of 1.5; μ and ν are random variables used to describe the parrot's flight conditions, both of which obey normal distribution. σ is related to the dispersion of Levy distribution and controls the range of Levy distribution. σ is a fixed value. Step 3: Staying stage: The parrot suddenly flies to any part of the owner's body and stays still for a period of time. The mathematical expression is as follows: In the formula, ones(1,dim) is a vector of all 1s of dimension dim, O best Levy(dim) represents the process of the parrot flying towards the owner, that is, the process of the liquid temperature approaching the target temperature, rand(0,1)·ones(1,dim) represents the process of the parrot randomly stopping at a certain part of the owner's body; Step 4: Communication stage; communication behaviors include flying toward the flock and not flying toward the flock. In PO, it is assumed that the probability of these two behaviors is equal, and the average position of the current population is used to symbolize the center of the group, indicating that within a certain error range, the current heating method is maintained to make the liquid temperature close to the target temperature. If it exceeds a certain error range, the heating method is changed to make the liquid temperature close to the target temperature. The mathematical expression is as follows: In the formula, It indicates the process of individuals joining the parrot group to communicate, that is, the error between the liquid temperature and the target temperature is small, and the current heating method is continued to make the liquid temperature approach the target temperature. It represents the process in which the individual flies out immediately after the communication, that is, the error between the liquid temperature and the target temperature is large. The heating method is changed to make the liquid temperature close to the target temperature. Both behaviors are feasible. Therefore, P randomly generated in the range of [0,1] is used to achieve this; Step 5: Fear stage: The parrot keeps a distance from unfamiliar individuals and seeks a safe environment with its owner, that is, to find the optimal solution for the liquid temperature closest to the target temperature. The mathematical expression is as follows: In the formula, Indicates the process of redirecting the flight towards the owner. It means the process of moving away from strangers; The final output That is, the actual temperature of the liquid that is closest to the target temperature, while outputting the best heating power, heating angle and heating time.

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