A system for separating and purifying 1,3-propanediol from a microbial fermentation broth and its application

The system, composed of membrane technology and distillation technology, solves the problems of high energy consumption, complexity and pollution in the separation and purification of 1,3-propanediol produced by microbial fermentation, and achieves efficient and environmentally friendly separation and purification of 1,3-propanediol to obtain high-purity products.

CN118925505BActive Publication Date: 2026-04-07INSTITUTE OF PROCESS ENGINEERING CHINESE ACADEMY OF SCIENCES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-07-23
Publication Date
2026-04-07

AI Technical Summary

Technical Problem

Existing methods for separating and purifying 1,3-propanediol produced by microbial fermentation are energy-intensive, complex to operate, expensive, and may cause secondary pollution to the environment, making it difficult to achieve efficient and environmentally friendly separation and purification.

Method used

A system consisting of a microfiltration membrane module, an ultrafiltration membrane module, an electrodialysis unit, a nanofiltration membrane module, and a distillation unit is used to separate and purify 1,3-propanediol through membrane technology and distillation technology. This process achieves the removal of microbial cells or cell debris, the retention and separation of proteins, polysaccharides, and nucleic acids, the removal of salts, and the separation of small molecule organic acids and neutral solutes, ultimately yielding a high-purity 1,3-propanediol product.

Benefits of technology

It achieves high-yield separation and purification of 1,3-propanediol with high purity, simple operation, no additional waste generation, and reduced energy consumption and cost.

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Abstract

This invention relates to a system for separating and purifying 1,3-propanediol from microbial fermentation broth and its application. The system comprises a microfiltration membrane module, an ultrafiltration membrane module, an electrodialysis unit, a nanofiltration membrane module, and a distillation unit connected in sequence. Based on membrane and distillation technologies, this system offers advantages such as high operational flexibility, small space requirement, ease of operation, and no additional waste generation. It ultimately removes microbial cells or cell debris from the fermentation broth, retains and separates proteins, polysaccharides, and nucleic acids, removes salts, and separates small-molecule organic acids and neutral solutes, thereby purifying and enriching 1,3-propanediol to obtain a 1,3-propanediol product with high purity.
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Citation Information

Patent Citations

  • Methods for edulcoration and desalinization of 1,3-methyl glycol fermentation liquor

    CN101117306A

  • Extraction and concentration device for 1, 3-propylene glycol fermentation liquor

    CN215049775U