An eye essence cream and a preparation method thereof

Abstract

The application relates to the technical field of eye care products, and particularly discloses an eye essence cream and a preparation method thereof. The eye essence cream comprises a moisturizing agent, an antioxidant, a penetration promoter, a viscosity regulator, an emulsifier, an emollient, a thickening agent, Coffea arabica seed oil, Baphia nitida bark extract, an anti-wrinkle composition, a Mei flower extract, a Pediococcus / Parsnip root ferment filtrate, an Adzuki bean seed extract, caprylyl glycol, acetyl hexapeptide-8, acetyl tetrapeptide-2, lactose, whey protein, lactic acid and the like. The anti-wrinkle composition is prepared by mixing acetyl hexapeptide-8, conotoxin, Hedychium spicatum extract, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7. The eye essence cream provided by the application has a comprehensive and efficient improvement effect on complex problems such as dry skin, fine lines, relaxation, dark circles and eye bags.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of eye care products, in particular to an eye serum cream and a preparation method thereof. BACKGROUND

[0002] The skin around the eyes is the thinnest part of the facial skin, only one quarter of the facial skin, contains rich capillaries, and lacks sebaceous glands and sweat glands, is prone to dryness and relaxation, and at the same time, due to the rich expression muscles of the skin around the eyes, daily repeated blinking, frowning and other expression movements, with the passage of time, these repeated expression movements will cause the skin around the eyes to produce wrinkles. Therefore, the skin around the eyes is one of the areas most prone to skin problems, and many consumers are often troubled by multiple eye skin problems such as fine lines, dryness, relaxation, dark circles, and eye bags.

[0003] At present, the eye care products are usually designed by adding different functional ingredients to improve the condition according to different eye skin problems. These eye care products usually add multiple functional ingredients such as moisturizing, antioxidant, firming and fine line lightening to cope with different eye skin problems and achieve comprehensive improvement of the eye skin. However, although these eye care products add complex and diverse functional ingredients, the actual use results are often disappointing. This is because the types of functional ingredients in these eye care products are diverse, and although theoretically, the more functional ingredients added, the more comprehensive and efficient the improvement of the eye skin may be, each functional ingredient has a unique chemical structure and properties. When multiple functional ingredients are mixed together, the interaction between them is complex and difficult to predict, and the compatibility, stability and safety between the functional ingredients are difficult to balance in the product formula. This may lead to a decrease or failure of the activity of certain functional ingredients, a lack of synergy between functional ingredients or a failure to fully exert the synergy, thereby failing to achieve the theoretical comprehensive improvement of the eye skin. Therefore, although there are numerous eye care products on the market, few products can comprehensively and effectively solve the complex problems of the eye skin. Therefore, it is necessary to optimize the formula design of eye care products in depth to achieve good synergy between functional ingredients and bring more comprehensive and effective care effects to the eye skin. SUMMARY

[0004] In order to achieve good synergy between functional ingredients in eye care products and bring more comprehensive and effective care effects to the eye skin, the present application provides an eye serum cream and a preparation method thereof. The present application surprisingly found that under the formula design of the present application, the functional ingredients can exhibit significant synergistic effect, not only improving the bioavailability of each functional ingredient, but also significantly enhancing the overall skin care effect of the eye serum cream, bringing more comprehensive and efficient care effects to the eye skin.

[0005] In a first aspect, the application provides an eye serum that employs the following technical solutions:

[0006] An eye serum, which is composed of A phase, B phase, C phase, D phase, E phase, F phase, G phase, H phase, I phase, and contains 0.98%-28.05% A phase, 2%-29% B phase, 0.02%-1.5% C phase, 0.1%-2% D phase, 0.001%-0.2% E phase, 0.005%-0.485% F phase, 0.02%-1.5% G phase, 1.1%-11.4% H phase, and the rest of I phase, in terms of the mass percentage of the eye serum.

[0007] Among them, the A phase contains moisturizing agents, antioxidants, penetration enhancers and viscosity regulators, the B phase is composed of emulsifiers and emollients, the D phase is a thickening agent, the E phase is tetrahydropeperidine, the H phase is butylene glycol, and the I phase is water.

[0008] In terms of the mass percentage of the eye serum, the C phase is composed of 0.01%-1% Coffea Arabica Seed Oil and 0.01%-0.5% Buxus Serrata Bark Extract.

[0009] In terms of the mass percentage of the eye serum, the F phase is composed of 0.000775%-0.0179% anti-wrinkle composition, 0.0045-0.45% Yuloh Extract, 0.00002%-0.01% Lactobacillus Ferment Lysate / Radish Root Ferment Filtrate, 0.000002%-0.001% Adzuki Bean Seed Extract, 0.00001%-0.005% Glycol, 0.0000005%-0.00025% Acetyl Hexapeptide-8, 0.0000005%-0.00025% Acetyl Tetrapeptide-2, and 0.00000025%-0.000125% Citric Acid; the anti-wrinkle composition is prepared by mixing Acetyl Hexapeptide-8, Conotoxin Peptide, Hedychium Flavonoids Extract, Palmitoyl Tripeptide-1, and Palmitoyl Tetrapeptide-7.

[0010] In terms of the mass percentage of the eye serum, the G phase is composed of 0.01%-0.5% skin conditioning agents and 0.01%-1% stabilizers; in terms of the mass percentage of the skin conditioning agents, the skin conditioning agents are composed of lactose, whey protein, lactic acid, and water.

[0011] In the above technical solution, the present application selects the above-mentioned multiple functional components to comprehensively solve the eye skin problems. Specifically, the Coffea Arabica seed oil in phase C is extracted from Coffea Arabica seeds, rich in unsaturated fatty acids and antioxidant components, which can effectively scavenge free radicals, nourish the eye skin, promote the eye blood circulation, relieve the eye edema and dark circles and reduce the fine lines and wrinkles; the Pterocarpus marsupium bark extract contains rich pterostilbene, which has the effects of antioxidant and ultraviolet resistance, and can effectively lighten the skin and improve the skin resistance to the external environment.

[0012] The tetrahydropiperine in phase E is a kind of alkaloid compound, which has strong penetration-promoting effect, can increase the fluidity of lipid bilayer, promote the diffusion of functional components into the skin, and improve the utilization rate of various functional components in the eye serum.

[0013] The Prunus mume flower extract in phase F has excellent anti-wrinkle properties, which is rich in various active ingredients such as polyphenols and flavonoids, which can effectively promote the synthesis of eye skin collagen, enhance the elasticity of eye skin, and reduce the formation of eye skin fine lines and wrinkles. The filtrate of Leuconostoc / radish (Raphanus sativus) root ferment and the extract of Phaseolus angularis seeds are rich in various probiotic metabolites and natural moisturizing ingredients, have the effects of moisturizing and soothing, can deeply nourish the eye skin, relieve the fine lines and tightness caused by dryness of the eye, enhance the self-repairing ability of the eye skin, and keep the skin moist and full.

[0014] Acetyl hexapeptide-8 and acetyl tetrapeptide-2 in phase F are anti-wrinkle peptides, which can simulate the peptide signal molecules produced by the human body, promote the synthesis of collagen and elastic fibers in the eye skin, effectively fade the fine lines and wrinkles of the eye, and restore the tightness and elasticity of the eye skin.

[0015] The addition of octanediol in phase F not only can serve as a moisturizing agent to improve the moisturizing performance of the eye serum, but also can help the moisturizing serum to aggregate other active ingredients to better penetrate into the deep layer of the eye skin and play the effect.

[0016] The skin conditioning agent in G phase, taking lactose, whey protein and lactic acid as core ingredients, builds a mild and efficient skin conditioning system. Lactose and whey protein are rich in nutrients such as amino acids, vitamins and minerals, which can nourish and repair damaged eye skin cells; lactic acid as a natural fruit acid ingredient can slightly exfoliate aging keratin, promote skin cell renewal, and make the eye skin more delicate and smooth. At the same time, the stabilizer in G phase ensures the stability of the eye serum cream, prevents deterioration or delamination during storage and use, and ensures the durability of the quality of the eye serum cream.

[0017] The present application found in the research that the Coffea arabica seed oil, Dalbergia Bari extract in C phase and the skin conditioning agent taking lactose as the main ingredient in G phase have good synergistic effect, which is much better than the use effect of single active ingredient. The three complement each other, significantly promote the generation of hyaluronic acid in the eye skin, improve the hydration of the eye skin, increase the water content in the skin, fill the grooves in the bottom layer of the skin, quickly and effectively improve the dryness, fine lines and relaxation problems of the eye skin, at the same time, the skin supported in this way has better absorption capacity, which can better penetrate other active ingredients in the eye serum cream.

[0018] The Meihua extract in F phase combined with the Streptococcus / Red Radish Root Ferment Filtrate and the Adzuki Bean Seed Extract can significantly improve the metabolism of eye skin cells, accelerate the renewal of aging cells, promote the decomposition of melanin in eye skin, eliminate dark circles, and make the eye skin more firm, smooth and transparent.

[0019] In addition, the present application limits the anti-wrinkle composition to be composed of acetyl hexapeptide-8, conotoxin, Zingiber Zerumbet extract, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7, which exhibits good synergistic effect with other active ingredients in the eye serum cream. The combination of the anti-wrinkle composition with other active ingredients in the eye serum cream improves the long-term anti-wrinkle effect of the eye serum cream. Specifically, the combination of Coffea arabica seed oil, Dalbergia Bari extract and skin conditioning agent taking lactose as the main ingredient in the present application can quickly support the eye skin, quickly and effectively improve the dryness, fine lines and relaxation problems of the eye skin, at the same time, this combination effect helps to enhance the penetration ability of the active ingredients. When other active ingredients such as anti-wrinkle composition in the present application penetrate into the deep layer of the skin, they can improve the eye skin condition at a deep level, promote collagen synthesis and elastic fiber regeneration, truly realize effective filling of eye skin fine lines, increase eye skin thickness, and long-term improve the dryness, fine lines and relaxation problems of the eye skin.

[0020] The eye essence cream of the present application realizes good synergistic effect among various functional components through careful matching of the above-mentioned various functional components. In the research, it is found that the matching of these functional components not only enables them to exert their unique skin care effects respectively, but also further enhances the comprehensive and efficient skin care effect of the eye essence cream through interaction. Whether it is to combat fine lines, dryness, laxity, dark circles or eye bags and other eye skin problems, the eye essence cream of the present application can provide effective solutions to make the eye skin radiate new brilliance.

[0021] Preferably, the anti-wrinkle composition comprises 0.00025% to 0.0025% acetyl hexapeptide-8, 0.00001% to 0.0001% conotoxin, 0.0005% to 0.015% red ginger extract, 0.00001% to 0.0002% palmitoyl tripeptide-1, 0.000005% to 0.0001% palmitoyl tetrapeptide-7, in terms of mass percentage of the eye essence cream.

[0022] In the above technical solution, the present application further improves the synergistic effect of the eye essence cream by further limiting the specific content ratio of the anti-wrinkle composition, while ensuring the mildness and safety of the product.

[0023] Preferably, the A phase comprises 0.77% to 14.45% humectants, 0.1% to 1.1% antioxidants, 0.1% to 2% penetration enhancers and 0.01% to 1% viscosity regulators, in terms of mass percentage of the eye essence cream.

[0024] In the above technical solution, the A phase is the aqueous phase base formula part of the eye essence cream. By limiting the amount of each raw material in the A phase, the present application maintains the balance and stability of the entire eye essence cream formula system, while ensuring that the eye essence cream not only maintains high efficient skin care effect, but also has good use experience. As an important component of the A phase, the humectant can help lock in skin moisture and reduce water evaporation, thereby maintaining the moist state of the eye skin. The antioxidant can resist the damage of the external environment to the eye skin, reduce the generation of free radicals and maintain the stability of the eye essence cream; the penetration enhancer can enhance the penetration of other functional components to the skin and improve the absorption efficiency; the viscosity regulator is responsible for adjusting the consistency of the product, making the eye essence cream easy to apply and not easy to flow, and further improving the stability of the eye essence cream together with the antioxidant.

[0025] Preferably, the A phase further comprises niacinamide, chlorella vulgaris polysaccharide, hydrolyzed collagen, dipotassium glycyrrhizate, caffeine and cyclodextrin, and the A phase further comprises 0.1% to 3% niacinamide, 0.095% to 0.9% chlorella vulgaris polysaccharide, 0.01% to 0.1% hydrolyzed collagen, 0.01% to 0.5% dipotassium glycyrrhizate, 0.05% to 2.5% caffeine and 0.05% to 2.5% cyclodextrin, in terms of mass percentage of the eye essence cream.

[0026] In the above technical solution, by adding the skin conditioning agent in phase A, a more comprehensive and deep moisturizing network can be formed on the skin surface in cooperation with the humectants, emollients, coffee seed oil, and khaya grandifolia bark extract, thereby further enhancing the water-locking effect of the eye serum cream and helping to further improve the overall health of the eye skin. Nicotinamide, as a widely known vitamin B3 derivative, not only has significant moisturizing effect, but also can effectively reduce the appearance of fine lines and wrinkles on the eye, promote skin repair and regeneration. The EUGLENA GRACILIS polysaccharide can deeply penetrate into the skin layer, enhance cell vitality and metabolism, and make the eye skin more compact and full. Hydrolyzed collagen, as a hydrolysis product of collagen, has a smaller molecular structure and is more easily absorbed by the skin, which can quickly replenish the collagen lost by the eye skin due to age or environmental stress, thereby enhancing the elasticity and tightness of the skin. Dipotassium glycyrrhizate has anti-inflammatory and soothing properties, which can effectively relieve the sensitivity and discomfort of the eye skin and reduce redness and inflammation caused by external stimuli. Caffeine, as a natural stimulant, can promote blood circulation in the eye, accelerate metabolism, effectively reduce puffiness and dark circles under the eyes, and restore the brightness and vitality of the eye skin when used in appropriate amounts in eye care products. Cyclodextrin, as a stabilizer, can stabilize other functional ingredients, improve the synergistic effect between the functional ingredients, and ensure the stability and durability of the eye serum cream during storage and use.

[0027] Preferably, the humectant of the A phase includes 1,2-hexanediol, ethylhexyl glycerin, 1,3-propanediol, glycerin, sodium lactate, xanthan gum, xylitol glucoside, anhydrous xylitol, xylitol, and betaine.

[0028] In the above technical solution, 1,2-hexanediol and ethylhexylglycerin not only have good moisturizing effect, but also can enhance the preservative performance of the product, ensure the safety and stability of the eye essence cream during use. 1,3-propanediol and glycerin are common moisturizing ingredients, which can quickly penetrate the skin and provide long-lasting moisturizing effect. Sodium lactate as a natural moisturizing factor can regulate skin acid-base balance and enhance skin barrier function. Xanthan gum can increase the viscosity of the product and improve the use experience. Xylitol glucoside, anhydrous xylitol and xylitol are a new generation of moisturizing ingredients, which can effectively lock in moisture and have certain antioxidant effect. Betaine can balance the osmotic pressure inside and outside the cell, reduce water loss and improve the water retention capacity of the eye skin. The present application selects 1,2-hexanediol, ethylhexylglycerin, 1,3-propanediol, glycerin, sodium lactate, xanthan gum, xylitol glucoside, anhydrous xylitol, xylitol and betaine as the moisturizing agent of phase A, and other functional ingredients in the eye essence cream, such as small euglena polysaccharide and hydrolyzed collagen, to form a multi-level moisturizing network on the skin surface, effectively improve the skin's own moisturizing ability. This synergistic effect not only improves the immediate moisturizing effect of the eye essence cream, but also enhances its long-term moisturizing ability, which helps to maintain the water-saturated state of the eye skin for a long time, thereby further relaxing the eye skin and improving the problems of dryness and fine lines of the eye skin.

[0029] Preferably, the antioxidant of the A phase is p-hydroxyacetophenone, the penetration enhancer of the A phase is bis-diethoxydiglycol cyclohexane 1,4-dicarboxylate, and the viscosity regulator of the A phase is composed of hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer, sorbitan isostearate and polysorbate-60.

[0030] In the above technical solution, the present application selects p-hydroxyacetophenone as an antioxidant, which not only can effectively scavenge free radicals and delay skin aging, but also can further maintain the stability of the eye essence cream formula. Bis-diethoxydiglycol cyclohexane 1,4-dicarboxylate as a penetration enhancer can enhance the penetration of other functional ingredients into the skin, improve the absorption efficiency and skin care effect of the eye essence cream. The viscosity regulator is composed of hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer, sorbitan isostearate and polysorbate-60, which can adjust the texture and stability of the product, ensure that the eye essence cream can be evenly applied to the eye skin during use, and improve the use experience.

[0031] Preferably, the emulsifier of the B phase includes cetylstearyl alcohol, cetylstearyl glucoside, polyglyceryl-6 distearate, jojoba esters, polyglyceryl-3 beeswax acid ester, cetyl alcohol, PEG-100 stearate and glyceryl stearate.

[0032] Preferably, the emollient of the B phase is composed of squalane, dimethicone and caprylic / capric triglyceride; the emollient of the B phase is composed of 0.1% to 5% squalane, 0.1% to 3% dimethicone and 1% to 10% caprylic / capric triglyceride, in terms of mass percentage of the eye serum emulsion.

[0033] In the above technical solution, the B phase as the core of the emulsification system of the eye serum emulsion is composed of emulsifiers and emollients. The specific selection of emulsifiers can stably combine the oil phase and the water phase of the eye serum emulsion together to form a uniform emulsion. The selection of emollients can give the eye skin a smooth and moisturizing touch, make up for the lack of sebaceous glands on the eye skin, form a light and thin water-locking film on the surface of the eye skin, further improve the moisturizing ability of the eye skin, and further improve the skin problems such as dryness, fine lines and relaxation of the eye skin in cooperation with other functional ingredients.

[0034] In the second aspect, the preparation method of the eye serum emulsion provided by the present application adopts the following technical solution:

[0035] The preparation method of the eye serum emulsion comprises the following steps:

[0036] Step 1: Mix the A phase, 70% to 80% of the H phase and 70% to 80% of the I phase by mass of the formula, and heat to 75-80℃ while stirring, and keep the temperature for 20-30 min;

[0037] Step 2: Mix the B phase raw materials, heat to 75-80℃ while stirring, then add the C phase raw materials, and stir and disperse uniformly;

[0038] Step 3: At 75-80℃, add the raw materials obtained in step 2 to the raw materials obtained in step 1, homogenize for 3-5 min, then add the D phase raw materials and continue to homogenize for 3-5 min, and then start to cool down;

[0039] Step 4: Cool down to below 45℃, add the mixture of E phase and the remaining H phase, F phase, G phase and the mixture of the remaining I phase, stir and disperse uniformly, and obtain the eye serum emulsion.

[0040] In the above technical solution, the present application ensures that each component can be fully integrated and play the best role through a reasonable preparation process, and ensures the excellent performance and stable quality of the eye serum emulsion.

[0041] Preferably, the stirring speed of step 1 is 20-35 Hz, the stirring speed of step 2 is 20-35 Hz, the homogenization speed of step 3 is 48-50 Hz, and the stirring speed of step 4 is 20-35 Hz.

[0042] In the technical solution, the stirring speed and homogenization speed of each step are accurately controlled during preparation to ensure that the phase raw materials are fully mixed and uniformly dispersed in the eye essence cream. The prepared eye essence cream has fine texture, is easy to apply and absorb, and can comprehensively and efficiently solve various problems of the eye skin such as fine lines, dryness, relaxation, dark circles, and eye bags.

[0043] In summary, the present application has the following beneficial technical effects:

[0044] The eye essence cream provided by the present application has significant synergistic effects among the various functional ingredients, not only improving the bioavailability of the functional ingredients, but also significantly enhancing the overall skin care effect of the eye essence cream. It has a comprehensive and efficient improvement effect on complex problems such as dryness, fine lines, relaxation, dark circles, and eye bags of the eye skin. DETAILED DESCRIPTION

[0045] To better illustrate the purpose, technical solution and advantages of the present application, the present application will be further described below in conjunction with specific examples.

[0046] Example 1

[0047] An eye essence cream is composed of A phase, B phase, C phase, D phase, E phase, F phase, G phase, H phase, and I phase.

[0048] The A phase is composed of a humectant, an antioxidant, a penetration enhancer, a viscosity regulator, and an A phase skin conditioner.

[0049] The humectant is composed of 1,2-hexanediol, ethylhexylglycerin, 1,3-propanediol, glycerin, sodium lactate, xanthan gum, xylitol glucoside, anhydrous xylitol, xylitol, and betaine.

[0050] The antioxidant is p-hydroxyacetophenone.

[0051] The penetration enhancer is bis-diethoxydiglycol cyclohexane 1,4-dicarboxylate.

[0052] The viscosity regulator is composed of hydroxyethyl acrylate / acryloyldimethyltaurate sodium copolymer, sorbitan isostearate, and polysorbate-60.

[0053] The A phase skin conditioner is composed of niacinamide, phlocrellum frustulum polysaccharide, hydrolyzed collagen, dipotassium glycyrrhizinate, caffeine, and cyclodextrin.

[0054] The B phase is composed of an emulsifier and an emollient.

[0055] Wherein the emulsifier is composed of cetylstearyl alcohol, cetylstearyl glucoside, polyglyceryl-6 distearate, simmondsia chinensis (jojoba) esters, polyglyceryl-3 beeswaxate, cetyl alcohol, PEG-100 stearate, glyceryl stearate.

[0056] Wherein the emollient is composed of squalane, dimethicone, and caprylic / capric triglyceride.

[0057] Wherein phase C is composed of coffea arabica (coffee) seed oil and pygeum africanum (prunus africana) bark extract.

[0058] Wherein phase D is a thickening agent.

[0059] Wherein the thickening agent is composed of hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, water, squalane, polysorbate-60, and sorbitan isostearate.

[0060] Wherein phase E is tetrahydrocumin.

[0061] Wherein phase F is composed of anti-wrinkle composition, prunus mume fruit extract, lactobacillus / raphanus sativus root ferment filtrate, phaseolus angularis seed extract, caprylyl glycol, acetyl hexapeptide-8, acetyl tetrapeptide-2, citric acid.

[0062] Wherein the anti-wrinkle composition is composed of acetyl hexapeptide-8, conotoxin, alpinia galanga extract, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7.

[0063] Wherein phase G is composed of phase G skin conditioning agent and stabilizer.

[0064] Wherein the phase G skin conditioning agent is composed of lactose, lactalbumin, lactic acid, water.

[0065] Wherein phase H is butylene glycol.

[0066] Wherein phase I is water.

[0067] Wherein the amount of each raw material of example 1 is shown in table 1.

[0068] Wherein the specific preparation method of the eye serum includes the following steps:

[0069] Step 1, pre-preparation: pre-mix phase A humectant, standby; pre-mix phase A viscosity regulator, standby; pre-mix phase A skin conditioner, standby; pre-mix phase D thickening agent, standby; pre-mix phase E and 25% of phase H by mass of the formula, standby; pre-mix the anti-wrinkle composition of phase F, then pre-mix the remaining raw materials of phase F and the anti-wrinkle composition, standby; pre-mix the skin conditioning agent of phase G, then pre-mix the skin conditioning agent, stabilizer and 25% of phase I by mass of the formula of phase G, standby.

[0070] Step 2: Mix the A phase, 75% by mass of the H phase, and 75% by mass of the I phase raw materials, stir at a stirring speed of 30 Hz, and warm up to 78°C, and continue to warm up and stir for 30 min.

[0071] Step 3: Mix the B phase raw materials, stir at a stirring speed of 30 Hz, and warm up to 78°C, then add the C phase raw materials, and stir and disperse uniformly at a stirring speed of 30 Hz.

[0072] Step 4: At 78°C, add the raw materials obtained in step 3 to the raw materials obtained in step 2, homogenize at a homogenization speed of 49 Hz for 4 min, then add the D phase raw materials and continue to homogenize for 4 min, and then start to cool down.

[0073] Step 5: Cool down to below 45°C, add the mixture of the E phase and the H phase, the F phase, the mixture of the G phase and the I phase, and stir and disperse uniformly at a stirring speed of 30 Hz to obtain the eye essence cream.

[0074] Example 2

[0075] An eye essence cream, which is different from example 1 in that the amounts of the raw materials are inconsistent.

[0076] The specific preparation method of the eye essence cream includes the following steps:

[0077] Step 1, pre-preparation: pre-mix the A phase moisturizer, reserve; pre-mix the A phase viscosity regulator, reserve; pre-mix the A phase skin conditioner, reserve; pre-mix the D phase thickening agent, reserve; pre-mix the E phase and 30% by mass of the H phase, reserve; pre-mix the anti-wrinkle composition of the F phase, then pre-mix the remaining raw materials of the F phase and the anti-wrinkle composition, reserve; pre-mix the skin conditioner of the G phase, then pre-mix the skin conditioner of the G phase, the stabilizer, and 30% by mass of the I phase, reserve.

[0078] Step 2: Mix the A phase, 70% by mass of the H phase, and 70% by mass of the I phase raw materials, stir at a stirring speed of 20 Hz, and warm up to 75°C, and continue to warm up and stir for 30 min.

[0079] Step 3: Mix the B phase raw materials, stir at a stirring speed of 20 Hz, and warm up to 75°C, then add the C phase raw materials, and stir and disperse uniformly at a stirring speed of 20 Hz.

[0080] Step 4: At 75°C, add the raw materials obtained in step 3 to the raw materials obtained in step 2, homogenize at a homogenization speed of 48 Hz for 5 min, then add the D phase raw materials and continue to homogenize for 5 min, and then start to cool down.

[0081] Step 5: Cool down to below 45℃, add the mixture of phase E and phase H, and the mixture of phase F, phase G and phase I, and stir and disperse evenly at a stirring speed of 20Hz to obtain the eye serum.

[0082] Example 3

[0083] An eye serum, which differs from Example 1 in that the amounts of each ingredient are different.

[0084] The specific preparation method of the eye serum includes the following steps:

[0085] Step 1, Pre-preparation: Premix phase A moisturizer, set aside; premix phase A viscosity modifier, set aside; premix phase A skin conditioning agent, set aside; premix phase D thickener, set aside; premix phase E and phase H (20% of the formula mass), set aside; premix phase F anti-wrinkle composition, then premix the remaining ingredients of phase F with the anti-wrinkle composition, set aside; premix phase G skin conditioning agent, then premix phase G skin conditioning agent, stabilizer and phase I (20% of the formula mass), set aside.

[0086] Step 2: Mix phase A, phase H (80% of the formula mass), and phase I (80% of the formula mass) raw materials, stir at a stirring speed of 35 Hz and heat to 80 ℃, and continue to stir and maintain the temperature for 20 min.

[0087] Step 3: Mix the B phase raw materials, stir at a stirring speed of 35 Hz and heat to 80 ℃, then add the C phase raw materials and stir at a stirring speed of 35 Hz to disperse them evenly.

[0088] Step 4: At 80℃, add the raw material obtained in Step 3 to the raw material obtained in Step 2, homogenize at a homogenization speed of 50Hz for 3 minutes, add the D phase raw material and continue homogenizing for 3 minutes, then start cooling.

[0089] Step 5: Cool down to below 45℃, add the mixture of phase E and phase H, and the mixture of phase F, phase G and phase I, and stir and disperse evenly at a stirring speed of 35Hz to obtain the eye serum.

[0090] Table 1: Specific Raw Material Usage for Examples 1-3 (Unit: kg)

[0091]

[0092]

[0093]

[0094] Example 4

[0095] An eye serum, unlike Example 1, has phase A skin conditioning agent replaced in equal amounts with Euglena pulvinata polysaccharide.

[0096] Comparative Example 1

[0097] An eye serum, different from Example 1, in which the Coffea Arabica (Coffee) Seed Oil in Phase C is replaced with equal amounts of Adansonia Digitata (Baobab) Seed Oil.

[0098] Comparative Example 2

[0099] An eye serum, different from Example 1, in which the Terminalia Catappa (Kapok Tree) Bark Extract in Phase C is replaced with equal amounts of Hibiscus Syriacus (Rose of Sharon) Bark Extract.

[0100] Comparative Example 3

[0101] An eye serum, different from Example 1, in which the skin conditioning agent in Phase G is replaced with equal amounts of Fructan.

[0102] Comparative Example 4

[0103] An eye serum, different from Example 1, in which the Prunus Mume (Japanese Apricot) Fruit Extract in Phase F is replaced with equal amounts of Rhodiola Sacra Root Extract.

[0104] Comparative Example 5

[0105] An eye serum, different from Example 1, in which the Lactobacillus Ferment Lysate and Red Clover Seed Extract in Phase F is replaced with equal amounts of Spigelia Anthemia (Pink Root) Extract and Lactobacillus / Soybean Ferment Extract.

[0106] Comparative Example 6

[0107] An eye serum, different from Example 1, in which the Acetyl Hexapeptide-8 in Phase F is replaced with equal amounts of Acetyl Tetrapeptide-2.

[0108] Comparative Example 7

[0109] An eye serum, different from Example 1, in which the anti-wrinkle composition in Phase F is replaced with equal amounts of Hydroxypropyl Tetrahydropyrantriol (Phospho-Sphingosine).

[0110] Test 1: Skin Occlusive Patch Test

[0111] Test Sample: The eye serum of each of the above examples and comparative examples.

[0112] Test Basis: The 2015 edition of the Cosmetics Safety Technical Specifications.

[0113] Test Method: A total of 30 test personnel were selected, and an area of no more than 50 mm 2The test material is added to the patch tester in an amount of about 0.020 g to 0.025 g. The patch tester with the test material and negative control is attached to the flexor side of the forearm of the subject, and after 24 hours the patch tester is removed. The skin reaction is observed according to the standard of Table 2 at 30 minutes after the patch tester is removed (after the indentation disappears), 24 hours and 48 hours, and the score grade is recorded.

[0114] Table 2: Skin reaction grading standard for skin occlusive patch test

[0115]

[0116] The test results show that the eye serum of Examples 1-4 and Comparative Examples 1-7 has a score grade of 0 at 30 minutes after the patch tester is removed (after the indentation disappears), 24 hours and 48 hours, and thus the eye serum of the present application is safe and non-irritating.

[0117] Test 2: Comparative test of synthesis of hyaluronic acid

[0118] Test sample: eye serum of each of the above examples and comparative examples Test method: normal human fibroblasts are cultured in a cell culture medium containing fetal bovine serum. When the cells are confluent, the culture medium is replaced, and the cells are cultured in the culture medium with the addition of the test sample for 72 hours. The control group uses only the culture medium, and the test group uses the culture medium containing 10% of the test sample for 72 hours of culture and study. The amount of hyaluronic acid synthesis is measured by colorimetry, and the relative growth rate of the test group relative to the control group is calculated for the amount of hyaluronic acid synthesis. The test results are shown in Table 3.

[0119] Table 3: Hyaluronic acid growth rate test results

[0120]

[0121] Test 3: verification of moisturizing, firming, anti-wrinkle, and dark circle lightening effects

[0122] Test sample: eye serum of each of the above examples and comparative examples Test subject: a total of 110 volunteers are recruited and randomly divided into 11 groups, 10 people in each group. The volunteer screening conditions are: age 35-54 years old, obvious lines around the eyes, healthy, no allergic diseases, no allergy to the test sample, and no application of laser and other removal methods in the past 3 months.

[0123] Method for use: the use site is half of the face, once a day in the morning and evening, each time after cleansing, take 2 pump samples, first apply to the whole eye area (including the upper and lower eyelids and the crow's feet area, first apply evenly and then gently press), then evenly apply to half of the face (focus on the cheekbone position) and gently massage until the lotion is completely absorbed, continuously use for 27 days, and use a placebo on the 28th day.

[0124] Detection method: the detection indexes include the water content, elasticity, glossiness, melanin, visual assessment rating of dark circles under the eyes and visual assessment rating of under-eye lines, wherein the instrument measurement parameter description is shown in Table 4, and the visual assessment rating of dark circles under the eyes and the visual assessment rating of under-eye lines are as follows:

[0125] The standard description of the visual assessment rating of dark circles under the eyes is as follows (readable 0.5 levels): 0 level: no dark circles; 1 level: almost imperceptible dark circles; 2 level: slight dark circles; 3 level: mild dark circles; 4 level: mild to moderate visible dark circles; 5 level: moderate obvious dark circles; 6 level: moderate to obvious dark circles; 7 level: moderate to clear dark circles; 8 level: obvious clear dark circles; 9 level: extensive severe dark circles.

[0126] The standard description of the visual assessment rating of under-eye lines is as follows (readable 0.5 levels): 0 level: tight and smooth skin under the orbit; 1 level: slightly thickened texture of skin under the orbit; 2 level: deepened texture of skin under the orbit; 3 level: more superficial fine lines under the inner canthus; 4 level: superficial fine lines under the inner canthus extending to the under-orbital area; 5 level: moderate wrinkles under the inner canthus; 6 level: moderate wrinkles under the inner canthus extending to the under-orbital area; 7 level: a small amount of severe wrinkles under the inner canthus and the under-orbital area; 8 level: a large amount of severe wrinkles under the inner canthus and the under-orbital area.

[0127] Table 4: Instrument measurement parameter description

[0128]

[0129]

[0130] The above detection results are averaged, and the change rate of the detection value at each time period after use is calculated according to the formula: change rate = (Tn-T0) / T0*100%, which is shown in Tables 5-10, respectively.

[0131] Table 5: Detection results of water content in stratum corneum

[0132]

[0133]

[0134] Table 6: Detection results of elasticity

[0135]

[0136]

[0137] Table 7: Glossiness detection results

[0138]

[0139] Table 8: Melanin detection results

[0140]

[0141]

[0142] Table 9: Dark circle visual assessment results

[0143]

[0144]

[0145] Table 10: Under-eye wrinkle visual assessment results

[0146]

[0147]

[0148] Specifically combined with Examples 1-4, Comparative Examples 1-7, and Tables 3-10, it can be concluded that the eye essence milk of the present application has a comprehensive and efficient improvement effect on complex problems such as dryness, fine lines, relaxation, dark circles, and puffiness of the eye skin.

[0149] Specifically combined with Example 1 and Comparative Examples 1-3, Comparative Examples 1-3 respectively replace the Coffea Arabica (Coffee) Seed Oil, Buxus Chinensis Bark Extract in the C phase and the skin conditioner mainly composed of lactose in the G phase, and Example 1 has a better effect of promoting the generation of hyaluronic acid and supplementing the instant moisture of the eye skin. Therefore, it can be seen that only the three of Coffea Arabica (Coffee) Seed Oil, Buxus Chinensis Bark Extract and the skin conditioner mainly composed of lactose in the G phase complement each other, which can quickly and effectively improve the dryness, fine lines and relaxation problems of the eye skin.

[0150] Specifically combined with Example 1 and Comparative Examples 4-5, Comparative Examples 4-5 respectively replace the Prunus Mume Fruit Extract, Leuconostoc Ferment Filtrate / Radish Root Ferment Filtrate and Phaseolus Angularis Seed Extract, and Example 1 has a good effect of improving dark circles. Therefore, it can be seen that only the Prunus Mume Fruit Extract combined with the Leuconostoc Ferment Filtrate / Radish Root Ferment Filtrate and the Phaseolus Angularis Seed Extract can cooperate with other effective ingredients in the eye essence milk to significantly promote the decomposition of melanin in the eye skin, eliminate dark circles, and make the eye skin more firm, smooth and transparent.

[0151] Specifically, according to the analysis of Example 1 and Comparative Example 6, in Comparative Example 6, the acetyl hexapeptide-8 in the F phase is replaced by acetyl tetrapeptide-2, and Example 1 has good effects on improving the problems of dryness, fine lines and relaxation of the eye skin. Therefore, it can be seen that although the anti-wrinkle composition in the present application already contains acetyl hexapeptide-8, the specific selection of acetyl hexapeptide-8 in the F phase and other efficacy components of the eye serum form a more synergistic effect, especially in terms of fine lines and relaxation problems of the eye skin, and exhibit more significant effects.

[0152] The specific embodiments are only an explanation of the present application, and are not a limitation of the present application. Those skilled in the art can make modifications to the embodiments without creative contributions after reading the specification, as long as the modifications are within the scope of the claims of the present application.

Claims

1. An eye serum, characterized in that, It consists of phases A, B, C, D, E, F, G, H, and I, and by weight percentage of the eye serum, it includes 0.98%~28.05% phase A, 2%~29% phase B, 0.02%~1.5% phase C, 0.1%~2% phase D, 0.001%~0.2% phase E, 0.005%~0.485% phase F, 0.02%~1.5% phase G, 1.1%~11.4% phase H, and the balance being phase I. Wherein, phase A includes humectants, antioxidants, penetration enhancers and viscosity modifiers, phase B is composed of emulsifiers and moisturizers, phase D is a thickener, phase E is tetrahydropiperine, phase H is butanediol and phase I is water; Phase A further includes niacinamide, Euglena galbana polysaccharide, hydrolyzed collagen, dipotassium glycyrrhizate, caffeine, and cyclodextrin. Based on the mass percentage of the eye serum, Phase A further includes 0.1%~3% niacinamide, 0.095~0.9% Euglena galbana polysaccharide, 0.01%~0.1% hydrolyzed collagen, 0.01%~0.5% dipotassium glycyrrhizate, 0.05%~2.5% caffeine, and 0.05%~2.5% cyclodextrin. Based on the mass percentage of the eye serum, phase C consists of 0.01%~1% coffee seed oil and 0.01%~0.5% palm bark extract; Based on the mass percentage of the eye serum, phase F comprises 0.000775%~0.0179% anti-wrinkle composition, 0.0045~0.45% plum blossom extract, 0.00002%~0.01% Leuconostoc mellitus / radish root fermentation product filtrate, 0.000002%~0.001% red bean seed extract, 0.00001%~0.005% caprylyl glycol, 0.0000005%~0.00025% acetyl hexapeptide-8, 0.0000005%~0.00025% acetyl tetrapeptide-2, and 0.00000025%~0.000125% citric acid; the anti-wrinkle composition is prepared by mixing acetyl hexapeptide-8, conopeptide, red ginger extract, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-7. Based on the mass percentage of the eye serum, phase G consists of 0.01% to 0.5% skin conditioning agent and 0.01% to 1% stabilizer. Based on the mass percentage of the skin conditioning agent, the skin conditioning agent consists of lactose, whey protein, lactic acid, and water.

2. The eye serum according to claim 1, characterized in that, Based on the mass percentage of the eye serum, the anti-wrinkle composition comprises 0.00025%~0.0025% acetyl hexapeptide-8, 0.00001%~0.0001% conopeptide, 0.0005%~0.015% red ginger extract, 0.00001%~0.0002% palmitoyl tripeptide-1, and 0.000005%~0.0001% palmitoyl tetrapeptide-7.

3. An eye serum according to claim 1, characterized in that, Based on the mass percentage of the eye serum, phase A comprises 0.77% to 14.45% moisturizer, 0.1% to 1.1% antioxidant, 0.1% to 2% penetration enhancer, and 0.01% to 1% viscosity modifier.

4. An eye serum according to claim 1, characterized in that, The humectants in phase A include 1,2-hexanediol, ethylhexylglycerin, 1,3-propanediol, glycerin, sodium lactate, xanthan gum, xylitol glucoside, dehydrated xylitol, xylitol, and betaine.

5. An eye serum according to claim 1, characterized in that, The antioxidant in phase A is p-hydroxyacetophenone, the penetration enhancer in phase A is bis-diethoxydiethylene cyclohexane 1,4-dicarboxylic acid ester, and the viscosity modifier in phase A is composed of hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer, sorbitan isostearate, and polysorbate-60.

6. An eye serum according to claim 1, characterized in that, The emulsifiers in phase B include cetearyl alcohol, cetearyl glucoside, polyglycerol-6 distearate, jojoba esters, polyglycerol-3 beeswax ester, cetearyl alcohol, PEG-100 stearate, and glyceryl stearate.

7. An eye serum according to claim 1, characterized in that, The emollient of phase B is composed of squalane, polydimethylsiloxane, and caprylic / capric triglycerides; based on the mass percentage of the eye serum, the emollient of phase B is composed of 0.1%~5% squalane, 0.1%~3% polydimethylsiloxane, and 1%~10% caprylic / capric triglycerides.

8. A method for preparing an eye serum as described in any one of claims 1 to 7, characterized in that, Includes the following steps: Step 1: Mix phase A, phase H (70%~80% of the formula mass), and phase I (70%~80% of the formula mass) while stirring and heating to 75-80℃, and keep warm for 20-30 minutes. Step 2: Mix the B phase raw materials, and while stirring, heat to 75-80℃, then add the C phase raw materials and stir to disperse evenly; Step 3: At 75-80℃, add the raw material obtained in Step 2 to the raw material obtained in Step 1, homogenize for 3-5 minutes, add the D phase raw material and continue homogenizing for 3-5 minutes, then start cooling. Step 4: Cool down to below 45°C, add the mixture of phase E and the remaining phase H, phase F, phase G and the remaining phase I, stir and disperse evenly to obtain the eye serum.

9. The method for preparing an eye serum according to claim 8, characterized in that, The stirring speed in step 1 is 20~35Hz, the stirring speed in step 2 is 20~35Hz, the homogenization speed in step 3 is 48~50Hz, and the stirring speed in step 4 is 20~35Hz.

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