New use of heparin sodium, moisturizing composition and its application and cosmetics

Abstract

The present invention belongs to the field of daily chemicals and discloses the use of sodium heparin to improve the skin feel of sodium hyaluronate solution. Sodium heparin can interact with sodium hyaluronate in the form of hydrogen bonds, thereby reducing the sticky skin feel of sodium hyaluronate. When sodium heparin is combined with Dendrobium officinale polysaccharide, the sticky skin feel of sodium hyaluronate can be further reduced. The present invention also provides a moisturizing composition, applications of the composition, and cosmetics.

Description

Technical Field

[0001] The invention belongs to the field of daily chemicals, and particularly relates to a new use of heparin sodium, a moisturizing composition and its application, and cosmetics. Background Art

[0002] CN115670959A discloses a refreshing, moisturizing, whitening and anti-allergic skin care product and its application. Specifically, the invention discloses a refreshing, moisturizing, whitening and anti-allergic skin care product and its application. The refreshing, moisturizing, whitening and anti-allergic skin care product is prepared by mixing component A with component B at a specific temperature, stirring evenly, cooling to a specific temperature, adding component C one by one, stirring evenly and cooling to room temperature. Component A consists of 10-25 parts of an alcohol compound, 0.2-3 parts of a viscosity controller, 0.1-0.5 parts of a surfactant, 0.8-3 parts of a conditioner, and 0.01-0.04 parts of a sustained-release agent; and component C consists of 0.05-0.8 parts of an antibacterial agent, 0.1-2.0 parts of an emulsion stabilizer, 0.1-2 parts of a plant extract, 0.05-3 parts of a synergist, and 0.01-0.05 parts of a pH regulator.

[0003] The conditioning agent includes one or a combination of allantoin, sodium hyaluronate, betaine, hydrolyzed sodium hyaluronate, trehalose, and sodium pyrrolidone carboxylate; the synergist includes one or a combination of collagen, tripeptide-1 copper, schizophyllan, sodium heparin, maltooligosaccharide glucoside, arginine, and hydrolyzed soy protein; and its components are relatively complex.

[0004] During the further research on sodium hyaluronate, the applicant faced a difficult problem: most sodium hyaluronates have a noticeably sticky feel on the skin after being used at a certain concentration. This is a very troublesome problem for daily chemical products that act directly on the skin.

[0005] The technical problem to be solved in this case is: how to improve the skin feel of sodium hyaluronate. Summary of the Invention

[0006] In view of the shortcomings of the existing technology, the purpose of the present invention is to provide a new use of sodium heparin. Sodium heparin can interact with sodium hyaluronate in the form of hydrogen bonds, thereby reducing the sticky skin feel of sodium hyaluronate. When sodium heparin is combined with Dendrobium officinale polysaccharide, the sticky skin feel of sodium hyaluronate can be further reduced.

[0007] At the same time, the present invention also provides a moisturizing composition, application of the composition, and cosmetics.

[0008] In order to achieve the purpose of the invention, the present invention adopts the following technical solutions:

[0009] Sodium heparin is used to improve the skin feel of sodium hyaluronate solution.

[0010] Sodium heparin can improve the sticky skin feel of sodium hyaluronate solution, mainly through its unique physical and chemical properties. The mechanism is as follows:

[0011] 1. Change the rheological properties of the solution

[0012] Sodium hyaluronate solutions have a high viscosity because hyaluronic acid molecules can form an extensive hydrogen bond network, making the solution highly viscous and sticky. Heparin sodium, as a polysulfated polysaccharide, has good rheological properties and can change the viscosity of the solution.

[0013] Reduce viscosity: Heparin sodium can interfere with the hydrogen bond network of hyaluronic acid molecules in the solution, reducing the overall solution viscosity and thus reducing the sticky feeling.

[0014] Improve fluidity: By improving the rheological properties of the solution, heparin sodium makes the solution more fluid and easier to spread, making the skin feel more comfortable during use.

[0015] 2. Enhance hydration

[0016] Heparin sodium has excellent humectant properties that enhance the hydration of the solution, which helps reduce the sticky feel.

[0017] Moisturizing effect: Sodium heparin molecules can absorb and retain a large amount of water, improve the skin's moisture balance, and reduce the sticky feeling on the skin surface caused by the high concentration of sodium hyaluronate.

[0018] Soft feeling: Enhanced hydration makes the skin surface softer and smoother, and reduces the sticky feeling on the skin surface after use.

[0019] 3. Biocompatibility and comfort

[0020] Sodium heparin has good biocompatibility and comfort, which can further enhance the user experience of sodium hyaluronate solution.

[0021] Biocompatibility: As a natural polysaccharide, heparin sodium has good compatibility with the skin and will not cause skin discomfort or allergic reactions.

[0022] Comfort: Sodium heparin can form a thin protective film on the skin surface, increasing skin comfort and reducing the sticky feeling caused by sodium hyaluronate solution.

[0023] 4. Anti-inflammatory and repair effects

[0024] Heparin sodium has anti-inflammatory and restorative properties to further enhance skin comfort.

[0025] Anti-inflammatory effect: Heparin sodium can reduce skin inflammation and irritation, providing a more comfortable use experience.

[0026] Repair function: Heparin sodium promotes skin repair, enhances skin barrier function, and makes the skin healthier, thereby reducing the sticky feeling caused by the use of sodium hyaluronate solution.

[0027] Through these effects, sodium heparin can effectively improve the sticky feel of sodium hyaluronate solution, making the solution more comfortable and smooth when used. This synergistic effect makes the combination of sodium hyaluronate and sodium heparin more effective in skincare products, providing both strong moisturizing and an enhanced user experience.

[0028] The invention discloses a method for improving the skin feel of sodium hyaluronate solution by using sodium heparin and Dendrobium officinale stem extract.

[0029] Both heparin sodium and Dendrobium officinale stem extract can improve the skin feel of sodium hyaluronate solution. The following is an explanation of their respective mechanisms of action and how they work together to improve the skin feel of sodium hyaluronate solution:

[0030] 1. Double Moisturizing Effect: Heparin sodium and Dendrobium officinale stem extract work together to enhance the solution's moisturizing properties. Heparin sodium absorbs moisture, while Dendrobium officinale stem extract locks in moisture. This dual moisturizing effect leaves skin more hydrated and reduces stickiness.

[0031] 2. Change the characteristics of the solution: Sodium heparin reduces the viscosity of the sodium hyaluronate solution, and Dendrobium officinale stem extract further improves the fluidity of the solution, making the solution easier to apply and improving the comfort of use.

[0032] 3. Double anti-inflammatory effect: Heparin sodium and Dendrobium officinale stem extract both have anti-inflammatory effects, reducing inflammation and irritation of the skin, making the skin more comfortable.

[0033] 4. Promote repair: Both work together to promote skin repair, enhance skin barrier function, make skin healthier and reduce stickiness.

[0034] 5. Antioxidant protection: The antioxidant effect of Dendrobium officinale stem extract protects the skin from damage by free radicals, improves skin health and increases comfort.

[0035] In summary, sodium heparin and Dendrobium officinale stem extract improve the skin feel of sodium hyaluronate solution through multi-faceted synergistic effects, making it more comfortable and smooth when used, and providing better moisturizing, anti-inflammatory and repair effects.

[0036] In the above-mentioned use, the amount of heparin sodium in the sodium hyaluronate solution is 0.001-0.2 wt%, and the amount of Dendrobium officinale stem extract in the sodium hyaluronate solution is 0.001-0.4 wt%;

[0037] The content of sodium hyaluronate in the sodium hyaluronate solution is 0.02-3 wt %.

[0038] In the above-mentioned use, the skin feel refers to the sticky feeling of the sodium hyaluronate solution on the skin.

[0039] At the same time, the present invention also discloses a moisturizing composition, comprising the following components in percentage by weight:

[0040] 0.1-1.0% sodium hyaluronate, 1.0-15.0% Dendrobium officinale stem extract, 0.01-2.0% sodium heparin; the main component of the Dendrobium officinale stem extract is Dendrobium officinale polysaccharide.

[0041] Sodium hyaluronate, due to its -COONa and -OH groups, has extremely strong moisturizing properties, locking in 1,000 times its weight in water for rapid hydration. The polysaccharide components in Dendrobium officinale can promote the expression of the aquaporin AQP3, transporting endogenous water, glycerol, and other small molecules in the skin into the epidermis, thereby directly or indirectly exerting its moisturizing effect. The main components of Dendrobium officinale stem extract are polysaccharides, which require a suitable network structure to perform effectively. Sodium hyaluronate can provide a carrier for these properties, thereby achieving the purpose of enhancing moisturizing properties. Sodium heparin can increase the permeability of blood vessels in the skin, improve local vascular circulation, promote the supply of nutrients to the skin and the excretion of metabolic waste, and facilitate the rapid transdermal absorption of sodium hyaluronate.

[0042] The combination of the above three can significantly improve the water retention performance of cosmetics.

[0043] The above-mentioned moisturizing composition includes the following components in weight percentage:

[0044] 0.1-1.0% sodium hyaluronate, 3.0-10.0% Dendrobium officinale stem extract, 0.1-1.0% heparin sodium.

[0045] In the above-mentioned moisturizing composition, the sodium hyaluronate is full molecular weight sodium hyaluronate.

[0046] In the above moisturizing composition, the sodium hyaluronate is HA60 or HA20.

[0047] At the same time, the present invention also discloses the use of any one or more of the above moisturizing compositions in preparing cosmetics.

[0048] Finally, the present invention also discloses a cosmetic comprising 0.1%-15wt% of any one of the above skin care compositions.

[0049] Compared with the prior art, the present invention has the following beneficial effects:

[0050] The present invention has found that sodium heparin can interact with sodium hyaluronate in the form of hydrogen bonds, thereby reducing the sticky skin feel of sodium hyaluronate. When sodium heparin is combined with Dendrobium officinale polysaccharide, the sticky skin feel of sodium hyaluronate can be further reduced.

[0051] The components of the composition described herein function as follows: Sodium hyaluronate, due to its -COONa and -OH groups, possesses strong moisturizing properties, capable of retaining 1,000 times its weight in water for rapid hydration. The polysaccharides in the Dendrobium officinale stem extract promote the expression of the aquaporin AQP3, transporting endogenous water, glycerol, and other small molecules into the epidermis, thereby directly or indirectly exerting a moisturizing effect.

[0052] The main component of Dendrobium officinale stem extract is polysaccharides. This type of substance needs to be in a suitable network structure to better exert its performance, and sodium hyaluronate can better provide a carrier for its performance, thereby achieving the purpose of enhancing moisturizing performance.

[0053] Heparin sodium can increase the vascular permeability of the skin, improve local vascular circulation, promote the supply of nutrients to the skin and the excretion of metabolic waste, and help the rapid transdermal absorption of sodium hyaluronate. DETAILED DESCRIPTION

[0054] The technical solution of the present invention is further described below by way of specific embodiments. It should be understood by those skilled in the art that the embodiments are merely to help understand the present invention and should not be regarded as specific limitations of the present invention.

[0055] Reagent Source:

[0056] HA60 / HA20: purchased from Shandong Guantianxia Biotechnology Co., Ltd.;

[0057] Heparin sodium: Shandong Guantianxia Biotechnology Co., Ltd.;

[0058] Dendrobium officinale stem extract: Shanghai Miaosen Biotechnology Co., Ltd.

[0059] Low and medium molecular weight sodium hyaluronate (molecular weight: 200,000 to 400,000): Trade name - Sodium hyaluronate (molecular weight 200,000-400,000), manufacturer - Shandong Anhua Biopharmaceutical Co., Ltd.

[0060] Medium-high molecular weight sodium hyaluronate (molecular weight: 800,000 to 1.5 million): Trade name - Sodium hyaluronate (molecular weight 800,000-1.5 million), manufacturer - Shandong Anhua Biopharmaceutical Co., Ltd.

[0061] Hydrangea extract: Beijing Oriental Miaosen Biotechnology Co., Ltd.

[0062] Part 1

[0063] Prepare hyaluronic acid solution according to the concentration in Table 1, disperse sodium hyaluronate, polysaccharide, and heparin sodium in water, and stir to form a uniform phase.

[0064] Table 1 Recipe table Unit: g

[0065]

[0066] Skin feel test

[0067] The test method is as follows: 40 subjects with normal healthy skin and no history of cosmetic allergies were selected, aged 20-40 years old, and divided into 4 groups with 10 subjects in each group according to the three embodiments and blank group 1. Each group tried 1 group of samples. Taking embodiments 1-3 and blank group 1 as an example, these four samples constituted 1 group.

[0068] Before application, clean the inside of your arm with a dry tissue. Then apply the corresponding sample at a rate of 2 mg / cm² until absorbed. Complete the questionnaire. Spreadability is scored on a scale of 1-10, with higher scores indicating smoother application and higher satisfaction. Absorption rate is scored on a scale of 1-10, with higher scores indicating faster absorption and higher satisfaction. Stickiness is scored on a scale of 1-10, with higher scores indicating less stickiness and higher satisfaction. The average values ​​for each group are shown in Table 2.

[0069] Table 2 Skin feel test results

[0070] Ductility Absorption rate sticky feeling Example 1 6.5 8.0 8.0 Example 2 6.9 8.4 9.0 Example 3 6.2 7.6 7.2 Blank group 1 6.0 7.4 5.9 Example 4 4.5 4.5 3.1 Example 5 5.0 4.9 4.0 Example 6 4.3 4.1 2.2 Blank group 2 4.0 3.8 1.4 Example 7 5.9 5.8 4.3 Example 8 7.9 8.6 8.6 Example 9 5.5 5.1 3.1 Blank group 3 5.0 4.5 2.2 Example 10 5.6 6.2 4.2 Example 11 7.7 8.9 8.9 Example 12 5.0 5.6 3.3 Blank group 4 4.6 5.0 2.3

[0071] Result analysis:

[0072] 1. Compared with the corresponding blank groups, Examples 1, 4, 7, and 10 all showed significant improvements in skin feel, and the extent of improvement was relatively similar.

[0073] 2. Examples 2, 5, 8, and 11 all showed significant improvements in skin feel compared to their respective blank groups, with Examples 8 and 11 showing more significant improvements.

[0074] 3. When Hydrangea extract was used instead of Dendrobium officinale stem extract, although both are polysaccharides, Dendrobium officinale stem extract had no substantial effect on the efficacy of heparin sodium. The applicant also needs to emphasize that although Hydrangea extract did not promote the efficacy of heparin sodium, it does not mean that other polysaccharides cannot promote the efficacy of heparin sodium. Other polysaccharides that can promote the efficacy of heparin sodium proposed by those skilled in the art are also within the scope of protection of this invention.

[0075] The hypothesized mechanism is that sodium heparin and Dendrobium officinale stem extract disrupt the hydrogen bonding network of hyaluronic acid molecules in solution, reducing the overall solution viscosity, thereby improving spreadability during application and accelerating absorption. Combined with these factors, the stickiness is significantly reduced.

[0076] Part 2

[0077] Prepare hyaluronic acid solution according to the concentration in Table 3, disperse sodium hyaluronate, polysaccharide, and heparin sodium in water, and stir to form a uniform phase.

[0078] Table 3 Recipe table Unit: g

[0079]

[0080]

[0081] Performance Testing

[0082] 1. Stimulus evaluation

[0083] The samples of Examples 13 to 19 of the present invention were subjected to multiple skin irritation tests in the skin irritation / corrosion test. The results showed that the samples of the present invention had almost no irritation to the skin. In addition, the samples of the present invention were subjected to the skin phototoxicity test and had no photosensitivity reaction.

[0084] 2. Skin moisture content test

[0085] A total of 42 subjects with normal healthy skin and no history of cosmetic allergies were selected, aged 20-40 years old. They were divided into 7 groups according to Examples 13-19 and Comparative Examples 1-7, with 6 subjects in each group. Two samples were tried in each group. The inside of the arm was cleaned before application by wiping it with a dry tissue. A skin moisture test probe from the German CK company was used. The initial value (0h) before use of the test sample was tested under a relative humidity of 20±1 and 50±10%. The corresponding sample was then applied at a dosage of 2 mg / cm2 until the sample was absorbed. The skin moisture content of the applied area was tested 4h and 8h after application of the product. The average value of each group was taken. The results are shown in Table 4.

[0086] Table 4 Test results of changes in skin moisture content

[0087]

[0088]

[0089] Result analysis:

[0090] 1. Comparison of Examples 13, 14, 15, and 16 reveals that Examples 13 and 16 provide the best results, while Example 15 exhibits the worst moisturizing effect. This may be due to the fact that, in the formulation of the present invention, HA60 and Dendrobium officinale stem extract are crucial for moisturizing. While the amount of HA60 used in Example 14 is small, the moisturizing polysaccharides in the Dendrobium officinale stem extract can partially compensate for the performance loss caused by its absence. While Example 15 increases the amount of HA60, the amount of Dendrobium officinale stem extract is relatively low. Even with a relatively rich network carrier, the low amount used alone results in limited moisturizing capacity, resulting in the worst results.

[0091] Example 19 of the present invention is inferior to Example 13. The fundamental reason is that the molecular weight of HA60 is significantly greater than that of HA20. In terms of moisturizing performance, the network structure of HA60 is more stable than that of HA20, resulting in better moisturizing effect and better performance of the polysaccharide's moisturizing properties. We speculate that HA20, Dendrobium officinale stem extract, and sodium heparin may have the best permeability of all the examples.

[0092] At the same time, it can be seen from Example 17 and Example 18 that when the hyaluronic acid in the present formula is low molecular weight hyaluronic acid and medium-high molecular weight hyaluronic acid, it has a similar trend.

[0093] 2. Comparative Examples 1 and 4 show that the use of sodium heparin alone does not contribute to the improvement of the moisturizing properties of HA60; Comparative Examples 1 and 2 show that the use of Dendrobium officinale stem extract alone significantly improves the moisturizing properties of HA60; Comparative Examples 1 and 3 show that the use of other polysaccharides instead of Dendrobium officinale stem extract does not significantly promote the improvement of the moisturizing properties of HA60, and may even have the opposite effect.

[0094] 3. It can be seen from Comparative Examples 3, 5-7 that when other types of polysaccharides are used, their moisturizing properties are significantly weaker than those of Example 13. The possible reasons are that, on the one hand, the moisturizing properties of the polysaccharides of the hydrangea extract may be inferior to those of the Dendrobium officinale stem extract; on the other hand, when they act on the film-forming carrier composed of sodium hyaluronate, they cannot maintain a relatively appropriate degree of influence with the hydrogen bond network, and thus cannot achieve the optimal moisturizing effect.

[0095] Part 3 Application Formula

[0096] The above combination of the present invention can be used for essence water, and its specific formula is shown in Table 7 below;

[0097] Table 7. Essence water formula containing the above skin care composition

[0098] Serial number Raw material name Percentage 1 Deionized water To 100 2 Disodium EDTA 0.02 3 Dipropylene glycol 2 4 Betaine 0.5 5 Xanthan gum 0.02 6 Butanediol 3 7 1,2-Hexanediol 0.5 8 p-Hydroxyacetophenone 0.5 9 The above skin care composition 0.1-15

[0099] The preparation process is:

[0100] Step 1: Clean and disinfect the necessary equipment, accurately weigh the raw materials of each component in the formula, and place them in clean and disinfected containers for later use.

[0101] Step 2: Add ingredients 1 to 5 to the main pot, stir and heat to 80-85℃, stirring until completely dissolved.

[0102] Step 3: Cool to 45°C, add ingredients 6 to 9, and stir well.

[0103] Step 4: Take samples to test various physical and chemical indicators, and filter out the material after passing the test.

[0104] The applicant declares that while the above-described embodiments illustrate the process of the present invention, the present invention is not limited to the above-described process steps, nor does it imply that the present invention must rely on the above-described process steps for implementation. Those skilled in the art should understand that any improvements to the present invention, equivalent substitutions for the raw materials used, additions of auxiliary ingredients, and selection of specific methods, etc., fall within the scope of protection and disclosure of the present invention.

Claims

1. The use of sodium heparin to improve the skin feel of a sodium hyaluronate solution; the skin feel refers to the sticky feeling of the sodium hyaluronate solution on the skin; the sodium hyaluronate content in the sodium hyaluronate solution is 0.02-3wt%; the amount of sodium heparin in the sodium hyaluronate solution is 0.001-0.2wt%; the sodium hyaluronate is full molecular weight sodium hyaluronate, low-molecular weight sodium hyaluronate with a molecular weight of 200,000 to 400,000, or high-molecular weight sodium hyaluronate with a molecular weight of 800,000 to 1.5 million.

2. The use according to claim 1, characterized in that The full molecular weight sodium hyaluronate is HA60 or HA20 produced by Shandong Guantianxia Biotechnology Co., Ltd.

3. The use of sodium heparin and Dendrobium officinale stem extract to improve the skin feel of sodium hyaluronate solution; the skin feel refers to the sticky feeling of sodium hyaluronate solution on the skin; the content of sodium hyaluronate in the sodium hyaluronate solution is 0.02-3wt%; the amount of sodium heparin in the sodium hyaluronate solution is 0.001-0.2wt%; the amount of Dendrobium officinale stem extract in the sodium hyaluronate solution is 0.001-0.4wt%; the sodium hyaluronate is full molecular weight sodium hyaluronate, medium-low molecular weight sodium hyaluronate with a molecular weight of 200,000 to 400,000, or medium-high molecular weight sodium hyaluronate with a molecular weight of 800,000 to 1.5 million.

4. The use according to claim 3, characterized in that The full molecular weight sodium hyaluronate is HA60 or HA20 produced by Shandong Guantianxia Biotechnology Co., Ltd.

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