A medicine bottle with low light transmittance and its preparation method

Abstract

The present application discloses a low light transmittance medicine bottle and its preparation method. The raw materials of the medicine bottle contain 3.5 - 5 wt% masterbatch, and the balance is high density polyethylene; by mass percentage, the raw materials of the masterbatch include: 40 - 50% titanium dioxide, 1 - 4% stabilizer, 2 - 5% dispersant, and the balance is carrier resin; the carrier resin includes high density polyethylene and a fluid modifier with a mass ratio of 100:10 - 30; the fluid modifier includes long chain fatty acid, linear low density polyethylene and maleic anhydride grafted polyethylene with a mass ratio of 5 - 10:10 - 20:5 - 10, and the carbon atom number of the long chain fatty acid is 12 - 20; at 190 °C and 2.16 Kg, the melt index of the linear low density polyethylene is 10 - 30 g / 10 min. The present application can significantly improve the light blocking property of the HDPE medicine bottle, reduce its light transmittance, and ensure the storage stability of the medicine.

Description

Technical Field

[0001] The present application relates to the field of pharmaceutical packaging materials, and particularly to a medicine bottle with low light transmittance and a preparation method thereof. Background Art

[0002] In the field of pharmaceutical packaging, pharmaceutical packaging bottles, as a key barrier to protect drugs from the external environment, their performance is directly related to the stability and safety of drugs. Among them, the light transmittance is one of the important indicators to measure the performance of pharmaceutical packaging bottles. Since many drugs are sensitive to light, especially ultraviolet light, long-term exposure to light may cause the active ingredients of drugs to degrade, discolor or produce adverse reactions. Therefore, it is crucial to ensure that pharmaceutical packaging bottles have sufficient light-blocking performance.

[0003] In the current market, in order to improve the light-blocking effect of medicine bottles, the commonly adopted strategy is to incorporate a large amount of titanium dioxide into the base resin of the medicine bottle. Titanium dioxide, with its excellent light reflection and light absorption capabilities, can significantly reduce the light transmittance of the medicine bottle, thereby effectively protecting drugs from light damage. However, directly adding titanium dioxide powder to the resin often faces the problem of uneven dispersion, which not only affects the light-blocking effect of the medicine bottle, but may also have an adverse impact on the molding processing performance of the medicine bottle and the appearance quality of the final product.

[0004] To overcome the above defects, the industry usually adopts the method of pre-mixing titanium dioxide with a carrier resin to prepare a masterbatch. The masterbatch technology helps to improve the dispersion of titanium dioxide in the base resin and increase its dispersion uniformity through the wrapping effect of the carrier resin. For example, the patent with the publication number CN106905669A discloses a titanium dioxide masterbatch and a preparation method thereof, which records that the dosage of titanium dioxide is 30-70%. However, although a high dosage of titanium dioxide can enhance the light-blocking effect, the melt fluidity and extrudability of the masterbatch will decrease significantly. On the one hand, it will cause melt fracture, poor filling in the mold, and appearance defects such as holes, bubbles, and rough surfaces; on the other hand, poor extrusion will result in uneven dispersion of titanium dioxide, causing an increase in the light transmittance of the medicine bottle and affecting the drug stability. This contradictory phenomenon limits the application of high-content titanium dioxide masterbatches in the production of medicine bottles. Summary of the Invention

[0005] The present application provides a medicine bottle with low light transmittance and a preparation method thereof, which can significantly alleviate the problem that the melt fluidity and extrudability decrease during the preparation of the masterbatch with a high dosage of titanium dioxide, resulting in an increase in the light transmittance of the medicine bottle.

[0006] In the first aspect, the present application provides a medicine bottle with low light transmittance, the raw materials of which contain 3.5-5 wt% of masterbatch, and the balance is high-density polyethylene; by mass percentage, the raw materials of the masterbatch include:

[0007] 40-50% titanium dioxide, 1-4% stabilizer, 2-5% dispersant, and the balance is the carrier resin;

[0008] The carrier resin includes high-density polyethylene and a fluid modifier in a mass ratio of 100:10-30; the fluid modifier includes long-chain fatty acids, linear low-density polyethylene, and maleic anhydride-grafted polyethylene in a mass ratio of 5-10:10-20:5-10, and the long-chain fatty acids have 12-20 carbon atoms; at 190°C and 2.16 Kg, the melt index of the linear low-density polyethylene is 10-30 g / 10 min.

[0009] Preferably, the long-chain fatty acid is at least one of palmitic acid, lauric acid, or stearic acid.

[0010] Preferably, the grafting rate of the maleic anhydride-grafted polyethylene is 1-2%.

[0011] In the present disclosure, the high-density polyethylene used as the raw material for the medicine bottle and the high-density polyethylene used as the carrier resin can be the same high-density polyethylene or different high-density polyethylenes can be selected.

[0012] Preferably, the melt index of the high-density polyethylene used as the raw material for the medicine bottle at 190°C and 2.16 Kg is 0.1-1 g / 10 min, and more preferably 0.2-0.5 g / 10 min.

[0013] For the raw material of the medicine bottle in the present disclosure, other processing aids of the polyethylene composition can be added according to the actual processing and use requirements, including but not limited to plasticizers, reinforcing agents, lubricants, flame retardants, antistatic agents, nucleating agents, fillers, and pigments, and their dosages are all conventional dosages or can be adjusted according to the requirements of the actual situation.

[0014] In the extrusion and preparation of the masterbatch, three points need to be noted to improve its fluidity. The first is the good flow of the melt in the screw barrel of the extruder, and the shear action of the screw is used to ensure the good dispersion of titanium dioxide; the second is that the melt needs to smoothly enter the die head from the end of the screw to prevent the phenomenon of retention and caking and blockage of the gate; the third is to ensure the compatibility between the components and improve the melting performance of the melt in the screw.

[0015] To achieve the above functions, the present application incorporates a fluid modifier into the carrier resin of the masterbatch, which includes long-chain fatty acids, linear low-density polyethylene, and maleic anhydride grafted polyethylene. Among them, the linear low-density polyethylene uses a high melt index material, which can effectively reduce the viscosity of the melt, improve the melt fluidity in the barrel, and contribute to the dispersion of titanium dioxide. Supplementary with long-chain fatty acids, it can effectively avoid the problem of melt retention and blockage at the die inlet, achieve good extrusion during the masterbatch preparation process, and improve the uniformity of titanium dioxide. The maleic anhydride grafted polyethylene can improve the compatibility between the components of the masterbatch, achieve good dissolution, and have an additional synergistic effect on improving the extrusion performance.

[0016] It should be noted that when the number of carbon atoms in the long-chain fatty acid is less than 12, its form is liquid, and there is a risk of migration and precipitation. The long-chain fatty acid with more than 20 carbon atoms is more difficult to obtain.

[0017] In addition, the melt index of the linear low-density polyethylene also needs to be appropriate. When the melt index is low, the fluidity is poor, while when the melt index is too high, the molecular weight of the material is low and the thermal stability is poor, which is not conducive to improving the extrusion performance.

[0018] Preferably, the surface of the titanium dioxide is grafted with a hydroxyl-terminated hyperbranched polyester through an isocyanate group silane coupling agent, and the mass ratio of the titanium dioxide, the isocyanate group silane coupling agent, and the hydroxyl-terminated hyperbranched polyester is 100:1-2:8-15.

[0019] Preferably, the isocyanate group silane coupling agent is γ-isocyanatopropyltrimethoxysilane and / or γ-isocyanatopropyltriethoxysilane.

[0020] Preferably, the hydroxyl value of the hydroxyl-terminated hyperbranched polyester is 200-400 mg KOH / g.

[0021] Preferably, the titanium dioxide is rutile titanium dioxide.

[0022] Preferably, the average particle size of the titanium dioxide is 0.1-10 microns, more preferably 0.1-0.5 microns.

[0023] It should be noted that the content of titanium dioxide in the present application should not be higher than 5% to meet the requirements of the national standard for the content of ignited residue.

[0024] The above surface modification of the present disclosure has the following effects:

[0025] First of all, the grafting of the hydroxyl-terminated hyperbranched polyester can inhibit the agglomeration tendency of titanium dioxide and ensure the dispersion effect.

[0026] Secondly, while the isocyanate group silane coupling agent realizes the chemical bonding between titanium dioxide and the hydroxyl-terminated hyperbranched polyester, it can consume the nucleation sites on its surface. In combination with the hydroxyl-terminated hyperbranched polyester with a hyperbranched structure, it can effectively weaken the promotion effect of titanium dioxide on the crystallization process of polyethylene during the subsequent blow molding of the medicine bottle, which is beneficial to reducing the crystallinity and lowering the light transmittance.

[0027] Thirdly, the hyperbranched structure of the hydroxyl-terminated hyperbranched polyester can form entanglements with the polymer, improving the light-blocking effect and reducing the light transmittance.

[0028] In addition, the hydroxyl-terminated hyperbranched polyester is attached to the surface of titanium dioxide, which can play a buffering and protective role to prevent the shear extrusion of the screw from damaging the light reflection ability of titanium dioxide.

[0029] It should be noted that the hydroxyl value of the hydroxyl-terminated hyperbranched polyester should be appropriate. Too low hydroxyl is not conducive to the grafting reaction, and too high hydroxyl is not conducive to improving the compatibility.

[0030] Preferably, an alkyl silane coupling agent is also grafted on the surface of the titanium dioxide. The alkyl silane coupling agent has 8 to 12 carbon atoms, and the mass ratio of the alkyl silane coupling agent to the isocyanate group silane coupling agent is 1 to 2:0.5 to 2.

[0031] Preferably, the alkyl silane coupling agent is selected from at least one of octyltrimethoxysilane, octyltriethoxysilane, decyltrimethoxysilane, decyltriethoxysilane, dodecyltrimethoxysilane, and dodecyltriethoxysilane.

[0032] The main purpose of grafting the above alkyl silane coupling agent in the present disclosure is to improve the compatibility between the grafted titanium dioxide and the polyethylene substrate. In addition, it can also reduce the friction coefficient of titanium dioxide, which helps to improve the melt fluidity.

[0033] Preferably, the stabilizer includes calcium stearate and zinc stearate with a mass ratio of 1 to 2:1 to 2.

[0034] Preferably, the dispersant is polyethylene wax.

[0035] In a second aspect, the present application provides a method for preparing a low-light-transmittance medicine bottle, which includes the following steps:

[0036] Prepare raw materials according to the raw material ratio described in any one of claims 1 to 9;

[0037] Mix the masterbatch raw materials, extrude and pelletize to obtain the masterbatch. The temperature of the extruder is set at 200 to 240 °C;

[0038] Melt the high-density polyethylene and the masterbatch at 200 to 250 °C, inject them into a preform, blow-mold the preform, and demold to obtain the product.

[0039] In summary, the present application has the following beneficial effects:

[0040] In the present application, a fluid modifier obtained by compounding long-chain fatty acids, linear low-density polyethylene, and maleic anhydride-grafted polyethylene is added to the carrier resin of the masterbatch, effectively alleviating the problems of poor fluidity and extrudability of the fluid in the barrel and at the gate of the die when the masterbatch is prepared with a high titanium dioxide content, improving the quality of the masterbatch, promoting the uniform dispersion of titanium dioxide, helping to improve the dispersion of titanium dioxide in the medicine bottle, and exerting its light reflection and light absorption effects to effectively reduce the light transmittance.

[0041] In addition, by grafting hydroxyl-terminated hyperbranched polyester on the surface of titanium dioxide, the present application can inhibit the agglomeration tendency and nucleation effect of titanium dioxide, promote the entanglement of titanium dioxide and the polymer, and prevent the damage of titanium dioxide by the shearing effect, effectively improving the light-blocking effect. Specific Embodiments

[0042] Preparation Examples

[0043] Preparation Example 1

[0044] Modified titanium dioxide was prepared as follows:

[0045] In 8 L of an ethanol aqueous solution (ethanol 30 wt%) with a pH of 4, 16 g of γ-isocyanatopropyltrimethoxysilane and 10 g of n-octyltrimethoxysilane were added, stirred for 10 min, and then 1000 g of rutile titanium dioxide (D50 particle size of 0.2 μm) was added and stirred for reaction for 20 min. The temperature was raised to 60 °C, 100 g of hydroxyl-terminated hyperbranched polyester (hydroxyl value of 320 mg KOH / g and molecular weight of 1000) was added, and stirred for reaction for 35 min. The titanium dioxide was separated by filtration and washed with deionized water until neutral to obtain modified titanium dioxide.

[0046] Preparation Example 2

[0047] Modified titanium dioxide was prepared as follows:

[0048] In 8 L of an ethanol aqueous solution (ethanol 30 wt%) with a pH of 4, 10 g of γ-isocyanatopropyltrimethoxysilane and 7 g of n-octyltrimethoxysilane were added, stirred for 10 min, and then 1000 g of rutile titanium dioxide (D50 particle size of 0.2 μm) was added and stirred for reaction for 15 min. The temperature was raised to 55 °C, 80 g of hydroxyl-terminated hyperbranched polyester (hydroxyl value of 220 mg KOH / g and molecular weight of 6400) was added, and stirred for reaction for 35 min. The titanium dioxide was separated by filtration and washed with deionized water until neutral to obtain modified titanium dioxide.

[0049] Preparation Example 3

[0050] Modified titanium dioxide, the preparation steps are as follows:

[0051] In 8 L of an ethanol aqueous solution (30 wt% ethanol) with a pH of 4, add 20 g of γ - isocyanatopropyltrimethoxysilane and 20 g of dodecyltrimethoxysilane, stir for 10 min, then add 1000 g of rutile titanium dioxide (D50 particle size is 0.3 μm), and stir and react for 20 min. Heat up to 60 °C, add 150 g of hydroxyl - terminated hyperbranched polyester (hydroxyl value 360 mgKOH / g, molecular weight 950), and stir and react for 40 min. Separate and filter out the titanium dioxide, wash it with deionized water until neutral to obtain modified titanium dioxide.

[0052] Preparation Example 4

[0053] Modified titanium dioxide, the difference from Preparation Example 1 is that n - octyltrimethoxysilane is replaced with an equal amount of γ - isocyanatopropyltrimethoxysilane.

[0054] Preparation Example 5

[0055] Modified titanium dioxide, the difference from Preparation Example 1 is that γ - isocyanatopropyltrimethoxysilane is replaced with an equal amount of n - octyltrimethoxysilane.

[0056] Preparation Example 6

[0057] Modified titanium dioxide, the difference from Preparation Example 1 is that hydroxyl - terminated hyperbranched polyester is replaced with an equal amount of n - octyltrimethoxysilane. Example

[0058] Example 1, a low - light - transmittance medicine bottle, the preparation method is as follows:

[0059] Masterbatch preparation: Take 10 kg of raw materials, and the raw material ratio is 48.3% of the modified titanium dioxide in Preparation Example 1, 1.5% of calcium stearate, 1.3% of zinc stearate, 3.5% of polyethylene wax, 2.0% of lauric acid, 3.8% of linear low - density polyethylene (melt index is 20 g / 10 min at 190 °C and 2.16 Kg, Vicat softening point is 94 °C), 1.5% of maleic anhydride - grafted polyethylene (grafting rate 1.2%), 38.1% of high - density polyethylene (melt index is 0.35 g / 10 min at 190 °C and 2.16 Kg). Add the raw materials into a high - speed mixer and mix evenly, then add them into a twin - screw extruder for melt extrusion granulation, and through water cooling, drying, and pelletizing, obtain masterbatch with an average particle size of 3 mm. The temperature of the extruder is set at 200 - 240 °C, and the temperature of each section from the feeding port to the head is: 200 °C, 210 °C, 215 °C, 220 °C, 240 °C, 220 °C, 215 °C, 210 °C, 210 °C, 200 °C.

[0060] Injection blow molding: 95.5 kg of high-density polyethylene (with a melt index of 0.35 g / 10 min at 190 °C and 2.16 Kg) and 4.5 kg of the above-mentioned masterbatch are melted at 215 - 235 °C, injection molded into preforms, and the preforms are blow molded and demolded to obtain the product. Among them, the temperature of the first section of the extruder is 215 °C, the second section is 228 °C, the third section is 235 °C, the fourth section is 235 °C, the nozzle is 235 °C, and the runner is 230 °C.

[0061] Example 2. A low light transmittance medicine bottle is prepared as follows:

[0062] Masterbatch preparation: Take 10 kg of raw materials. The raw material ratio is 40.6% of the modified titanium dioxide in Preparation Example 2, 1.7% of calcium stearate, 1.6% of zinc stearate, 2.7% of polyethylene wax, 1.4% of palmitic acid, 3.0% of linear low-density polyethylene (with a melt index of 25 g / 10 min at 190 °C and 2.16 Kg, and a Vicat softening point of 91.7 °C), 1.5% of maleic anhydride grafted polyethylene (grafting rate of 1.0%), and 47.5% of high-density polyethylene (with a melt index of 0.35 g / 10 min at 190 °C and 2.16 Kg). Add the raw materials to a high-speed mixer and mix evenly, then add them to a twin-screw extruder for melt extrusion and pelletization. After water cooling, drying, and pellet cutting, masterbatch with an average particle size of 3 mm is obtained. The extruder temperature is set at 200 - 240 °C, and the temperature of each section from the feeding port to the head is: 200 °C, 210 °C, 220 °C, 230 °C, 240 °C, 220 °C, 215 °C, 210 °C, 210 °C, 200 °C.

[0063] Injection blow molding: 96.5 kg of high-density polyethylene (with a melt index of 0.35 g / 10 min at 190 °C and 2.16 Kg) and 3.5 kg of the above-mentioned masterbatch are melted at 215 - 235 °C, injection molded into preforms, and the preforms are blow molded and demolded to obtain the product. Among them, the temperature of the first section of the extruder is 215 °C, the second section is 228 °C, the third section is 235 °C, the fourth section is 235 °C, the nozzle is 235 °C, and the runner is 230 °C.

[0064] Example 3. A low light transmittance medicine bottle is prepared as follows:

[0065] Masterbatch preparation: Take 10 kg of raw materials. The raw material ratio is 48.3% of the modified titanium dioxide of Preparation Example 3, 1.5% of calcium stearate, 1.3% of zinc stearate, 3.5% of polyethylene wax, 2.0% of stearic acid, 3.8% of linear low-density polyethylene (melt index of 12 g / 10 min at 190 °C and 2.16 Kg, Vicat softening point of 94 °C), 1.5% of maleic anhydride grafted polyethylene (grafting rate of 1.2%), and 38.1% of high-density polyethylene (melt index of 0.23 g / 10 min at 190 °C and 2.16 Kg). Add the raw materials into a high-speed mixer and mix evenly, then add them into a twin-screw extruder for melt extrusion and pelletization. After water cooling, drying, and pellet cutting, masterbatch with an average particle size of 3 mm is obtained. The temperature of the extruder is set at 200 - 240 °C, and the temperatures of each section from the feeding port to the die head are: 200 °C, 210 °C, 215 °C, 220 °C, 240 °C, 220 °C, 215 °C, 210 °C, 210 °C, 200 °C.

[0066] Injection blow molding: Melt 95.0 kg of high-density polyethylene (melt index of 0.35 g / 10 min at 190 °C and 2.16 Kg) and 5.0 kg of the above masterbatch at 200 - 235 °C, inject and mold them into preforms, and then blow mold the preforms to obtain the product after demolding. Among them, the temperature of the 1st section of the extruder is 200 °C, the 2nd section is 215 °C, the 3rd section is 225 °C, the 4th section is 235 °C, the nozzle is 235 °C, and the runner is 230 °C.

[0067] Example 4, a low light transmittance medicine bottle, which is different from Example 1 in that the modified titanium dioxide of Preparation Example 4 is used to replace the modified titanium dioxide of Preparation Example 1 in equal amount.

[0068] Example 5, a low light transmittance medicine bottle, which is different from Example 1 in that the modified titanium dioxide of Preparation Example 5 is used to replace the modified titanium dioxide of Preparation Example 1 in equal amount.

[0069] Example 6, a low light transmittance medicine bottle, which is different from Example 1 in that the modified titanium dioxide of Preparation Example 6 is used to replace the modified titanium dioxide of Preparation Example 1 in equal amount. Comparative example

[0070] Comparative Example 1, a low light transmittance medicine bottle, which is different from Example 6 in that in the masterbatch raw materials, lauric acid is replaced by maleic anhydride grafted polyethylene (grafting rate of 1.2%) in equal amount.

[0071] Comparative Example 2, a low light transmittance medicine bottle, which is different from Example 6 in that in the masterbatch raw materials, linear low-density polyethylene is replaced by high-density polyethylene (melt index of 0.35 g / 10 min at 190 °C and 2.16 Kg) in equal amount.

[0072] Comparative Example 3, a low light transmittance medicine bottle, which is different from Example 6 in that in the masterbatch raw materials, linear low density polyethylene (with a melt index of 20 g / 10 min at 190 °C and 2.16 Kg, and a Vicat softening point of 94 °C) is used to replace maleic anhydride grafted polyethylene in equal amounts.

[0073] Comparative Example 4, a low light transmittance medicine bottle, which is different from Example 6 in that in the masterbatch raw materials, high density polyethylene (with a melt index of 0.35 g / 10 min at 190 °C and 2.16 Kg) is used to replace lauric acid, linear low density polyethylene and maleic anhydride grafted polyethylene in equal amounts.

[0074] Performance detection test

[0075] Test 1: Appearance quality of masterbatch

[0076] Among the masterbatch prepared in each example and comparative example, 50 masterbatch were randomly selected, and the surface structure of the extruded products was observed with an optical microscope or an electron microscope to check whether there are appearance defects such as cavities, bubbles, and rough surfaces, and the appearance defect rate was calculated.

[0077] Test 2: Light transmittance test

[0078] (1) Specimen preparation: Select a sample with uniform thickness, cut a circular section from two or more bottle walls, clean it, dry it, and do not scratch the surface. If the sample is too small to cover the sample holder, cover the open part with opaque paper or tape. If the length of the sample is longer than the length of the spectrophotometer slit, install the sample holder stage and then install the sample with sticky wax or other simple methods. Pay attention to avoid finger prints or other marks on the surface, which may affect the passage of light.

[0079] (2) Detection method: Place the sample on a light conduction measurement spectrophotometer so that the central axis of the sample is parallel to the slit plane of the spectrophotometer and near the center of the slit. When the sample is placed in the appropriate position, the light beam reaches the sample surface normally and the reflection loss is minimized. Using air as a reference, measure the light transmittance of the sample in the required spectral region, and continuously record every 40 nm in the wavelength range of 290 nm - 450 nm with a recording instrument or a manual instrument.

[0080] Table 1. Test results

[0081]

[0082] Analysis of test results:

[0083] Combined with Examples 1-6 and Comparative Examples 1-4 and in conjunction with Table 1, it can be seen that by adding a fluid modifier composed of long-chain fatty acids, linear low-density polyethylene, and maleic anhydride-grafted polyethylene to the masterbatch, the fluidity and extrudability of the masterbatch raw material melt can be effectively improved under a high titanium dioxide content. While reducing the appearance defects of the masterbatch, it promotes the effective dispersion of titanium dioxide, contributing to obtaining an HDPE medicine bottle with a lower light transmittance. The reason may be that linear low-density polyethylene can reduce the viscosity of the melt in the extruder barrel and improve its fluidity; long-chain fatty acids can improve the extrudability of the melt when it enters the die from the barrel, preventing the melt from staying and clogging at the die inlet (the end of the screw); maleic anhydride-grafted polyethylene can improve the solubility between the raw materials of the melt and enhance the melt extrudability.

[0084] Furthermore, combined with Example 1 and Examples 4-6 and in conjunction with Table 1, it can be seen that grafting hydroxyl-terminated hyperbranched polyester and alkyl silane coupling agent on the surface of titanium dioxide in this application can effectively reduce the light transmittance of the medicine bottle. The reason may be that hydroxyl-terminated hyperbranched polyester has a significant effect on inhibiting the agglomeration tendency and nucleation of titanium dioxide. At the same time, it can promote the entanglement of titanium dioxide and the polymer, prevent the damage of titanium dioxide by shear force, etc., improving the light-blocking effect.

[0085] This specific embodiment is only an explanation of this application and is not a limitation of this application. After reading this specification, those skilled in the art can make modifications to this embodiment without creative contributions as needed, but as long as it is within the scope of the claims of this application, it is protected by the patent law.

Claims

1. A medicine bottle with low light transmittance, characterized in that, The raw material contains 3.5 - 5 wt% of masterbatch, and the balance is high-density polyethylene; By mass percentage, the raw materials of the masterbatch include: 40 - 50% of titanium dioxide, 1 - 4% of stabilizer, 2 - 5% of dispersant, and the balance is carrier resin; The carrier resin includes high-density polyethylene and a fluid modifier with a mass ratio of 100:10 - 30; the fluid modifier includes long-chain fatty acid, linear low-density polyethylene, and maleic anhydride grafted polyethylene with a mass ratio of 5 - 10:10 - 20:5 - 10, and the number of carbon atoms of the long-chain fatty acid is 12 - 20; at 190 °C and 2.16 Kg, the melt index of the linear low-density polyethylene is 10 - 30 g / 10 min; The surface of the titanium dioxide is grafted with a hydroxyl-terminated hyperbranched polyester through an isocyanate group silane coupling agent, and the mass ratio of the titanium dioxide, the isocyanate group silane coupling agent, and the hydroxyl-terminated hyperbranched polyester is 100:1 - 2:8 - 15; the surface of the titanium dioxide is also grafted with an alkyl silane coupling agent, the number of carbon atoms of the alkyl silane coupling agent is 8 - 12, and the mass ratio of the alkyl silane coupling agent to the isocyanate group silane coupling agent is 1 - 2:0.5 - 2.

2. The medicine bottle according to claim 1, wherein The long-chain fatty acid is at least one of palmitic acid, lauric acid, or stearic acid.

3. The medicine bottle according to claim 1, wherein The grafting rate of the maleic anhydride grafted polyethylene is 1 - 2%.

4. The medicine bottle according to claim 1, wherein The isocyanate group silane coupling agent is γ-isocyanatopropyltrimethoxysilane and / or γ-isocyanatopropyltriethoxysilane.

5. The medicine bottle according to claim 1, wherein The hydroxyl value of the hydroxyl-terminated hyperbranched polyester is 200 - 400 mgKOH / g.

6. The medicine bottle according to claim 1, wherein, The stabilizer includes calcium stearate and zinc stearate with a mass ratio of 1 - 2:1 - 2.

7. The medicine bottle according to claim 1, characterized in that, The dispersant is polyethylene wax.

8. A preparation method of a medicine bottle with low light transmittance, characterized in that, It includes the following steps: Prepare the raw materials according to the raw material ratio of the low light transmittance medicine bottle described in any one of claims 1 - 7; Mix the raw materials of the masterbatch, extrude and pelletize to obtain the masterbatch, and the temperature of the extruder is set at 200 - 240 °C; Melt the high-density polyethylene and the masterbatch at 200 - 250 °C, inject and mold them into preforms, and then blow-mold the preforms and demold to obtain the product.

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