A drug fermentation device for targeted release encapsulation technology

Abstract

The present invention relates to the technical field of pharmaceutical processing equipment, and in particular to a drug fermentation equipment for targeted release encapsulation technology, including a bracket and a fermentation tank; the bracket is connected to the fermentation tank. The present invention scrapes the inner wall of the fermentation tank by the edge of the first nozzle, so that the first nozzle scrapes and washes the inner wall of the fermentation tank, which is beneficial to improve the cleaning effect and avoid the problem that the drug residues tightly attached to the inner wall of the fermentation tank are difficult to clean only by water flushing; the stirring rod is wrapped by an isolation tube, so that when cleaning the drug residues attached to the inner wall of the fermentation tank by flushing, the drug residues splash back on the stirring rod, and the cleaning space of the stirring rod is reduced, which is beneficial to enhance the water flow impact effect on the stirring rod during the cleaning process of the stirring rod, so that the residual drug residues can be better washed off.

Description

Technical Field

[0001] The invention relates to the technical field of pharmaceutical processing equipment, and in particular to a drug fermentation equipment for targeted release encapsulation technology. Background Art

[0002] Drug fermentation is an important technology in the modern pharmaceutical industry. It synthesizes the required drug ingredients through the growth and metabolism of microorganisms. However, after the fermentation process, drug residues often remain on the fermentation tank and stirring equipment, which need to be cleaned manually. In order to enhance the effect of the fermentation process, stirring is often used to ensure that the drugs are fully mixed and to increase dissolved oxygen. The stirring rod is usually close to the inner wall of the fermentation tank, that is, during the cleaning process, it is often affected by the stirring rod, resulting in low cleaning efficiency. In addition, the stirring rods are staggered and difficult to clean themselves. Summary of the invention

[0003] In order to overcome the disadvantages that the stirring rod is usually close to the inner wall of the fermentation tank, which leads to low cleaning efficiency due to the influence of the stirring rod during the cleaning process, and the stirring rods are staggered and difficult to clean, the present invention provides a drug fermentation device using targeted release encapsulation technology.

[0004] The technical solution is: a drug fermentation device for targeted release embedding technology, including a bracket and a fermentation tank; the fermentation tank is connected to the bracket; it also includes a mounting shell, an isolation cylinder, a motor, a rotating shaft, a stirring rod, a limiting plate, a first connecting pipe, a first nozzle, a discharge pipe, a second connecting pipe, a feeding pipe and a power component; the fermentation tank is connected to the mounting shell; the mounting shell is connected with a power component; the power component is connected to the isolation cylinder; the power component is used to drive the isolation cylinder to move; a rotating shaft is passed through the mounting shell, and the rotating shaft passes through the isolation cylinder and the fermentation tank and is rotatably connected to the bottom of the fermentation tank, and the rotating shaft is arranged in a hollow structure; a sealing member is fixedly connected to the rotating shaft The limiting plates of the isolation cylinder and the mounting shell are in contact with the inner wall of the isolation cylinder; a motor is fixedly connected to the mounting shell; the output shaft of the motor is fixedly connected to the rotating shaft; a plurality of stirring rods are fixedly connected to the rotating shaft, the stirring rods are located in the fermentation tank, the stirring rods are arranged as a hollow structure, and each stirring rod is provided with a plurality of through holes for conveying oxygen and water; a plurality of first connecting pipes are passed through the mounting shell, and the first connecting pipes are fixedly connected to the isolation cylinder; all the first connecting pipes are commonly connected to the first nozzle; a discharge pipe is connected to the fermentation tank; a second connecting pipe is connected to the fermentation tank, and the second connecting pipe is connected to the rotating shaft; a feed pipe is connected to the fermentation tank.

[0005] Furthermore, a filter is also included; the fermentation tank is connected to a filter for filtering waste gas.

[0006] Furthermore, a rubber ring is provided between the isolation cylinder and the fermentation tank.

[0007] Furthermore, a concave structure is provided at the position where the fermentation tank is connected to the discharge pipe.

[0008] Furthermore, bristles are arranged in the isolation tube.

[0009] Furthermore, one end of the stirring rod close to the rotating shaft is made of metal material, and the rest of the stirring rod is made of soft rubber material.

[0010] Furthermore, a rubber valve is arranged in each through hole of the stirring rod.

[0011] Furthermore, the first nozzle is closely fitted to the inner wall of the fermentation tank.

[0012] Furthermore, it also includes a cleaning component, which includes a third connecting pipe and a second nozzle; a plurality of third connecting pipes are passed through the mounting shell; all the third connecting pipes are commonly connected to the second nozzle; and the second nozzle is fixedly connected to the fermentation tank.

[0013] Furthermore, the water spray port of the second nozzle is arranged to be inclined toward the isolation tube.

[0014] The present invention has the following advantages: 1. The present invention scrapes the inner wall of the fermentation tank by the edge of the first nozzle, so that the first nozzle scrapes and washes the inner wall of the fermentation tank, which is beneficial to improve the cleaning effect and avoids the problem that the drug residues tightly attached to the inner wall of the fermentation tank are difficult to clean only by water washing;

[0015] 2. By wrapping the stirring rod with an isolation tube, it is possible to avoid the drug residue attached to the inner wall of the fermentation tank being splashed on the stirring rod by flushing, and the cleaning space of the stirring rod is reduced, which is beneficial to enhance the water flow impact effect on the stirring rod during the cleaning process, so that the residual drug residue can be better washed off;

[0016] 3. The present invention gradually flushes the stirring rod through the second nozzle. Driven by the water flow, the medicine residue can flow downward along the curved shape of the stirring rod. After the isolation tube completely wraps the stirring rod, the water sprayed from the second nozzle flushes the medicine residue attached to the outer surface of the isolation tube to prevent the medicine residue from entering the mounting shell during the subsequent resetting process of the isolation tube. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 A schematic diagram of the structure of a drug fermentation device for targeted release and embedding technology of the present invention;

[0018] Figure 2 This is a schematic diagram of the internal structure of the drug fermentation equipment used in the targeted release encapsulation technology of the present invention;

[0019] Figure 3 This is a schematic diagram of the combined structure of the first connecting pipe and the first nozzle of the drug fermentation equipment for targeted release and embedding technology of the present invention;

[0020] Figure 4 This is a schematic diagram of the combined structure of the second connecting pipe and the filter of the drug fermentation equipment for targeted release encapsulation technology of the present invention;

[0021] Figure 5 This is a schematic diagram of the structure of the cleaning component of the drug fermentation equipment used in the targeted release encapsulation technology of the present invention;

[0022] Figure 6 This is a schematic diagram of the combined structure of the third connecting pipe and the second nozzle of the drug fermentation equipment for targeted release encapsulation technology of the present invention.

[0023] The meanings of the reference numerals in the figure are: 1- bracket, 2- fermentation tank, 3- mounting shell, 4- electric slide rail, 5- electric slide block, 6- isolating cylinder, 7- motor, 8- rotating shaft, 9- stirring rod, 9001- rubber valve, 10- limiting plate, 11- first connecting pipe, 12- first nozzle, 13- discharge pipe, 14- second connecting pipe, 15- feeding pipe, 16- filter, 101- third connecting pipe, 102- second nozzle. DETAILED DESCRIPTION

[0024] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0025] Example 1

[0026] A drug fermentation device for targeted release encapsulation technology, such as Figure 1-Figure 4 As shown, it includes a support 1 and a fermentation tank 2; the support 1 is connected to the fermentation tank 2;

[0027] It also includes a mounting shell 3, an isolation cylinder 6, a motor 7, a rotating shaft 8, a stirring rod 9, a limiting plate 10, a first connecting pipe 11, a first nozzle 12, a discharge pipe 13, a second connecting pipe 14, a feeding pipe 15 and a power assembly; the fermentation tank 2 is connected to the mounting shell 3; the mounting shell 3 is connected to the power assembly; the power assembly is connected to the isolation cylinder 6; the power assembly is used to drive the isolation cylinder 6 to move; the mounting shell 3 is penetrated by a rotating shaft 8, the rotating shaft 8 passes through the isolation cylinder 6 and the fermentation tank 2 and is rotatably connected to the bottom of the fermentation tank 2, and the rotating shaft 8 is arranged in a hollow structure; the rotating shaft 8 is fixedly connected to the limiting plate 10, the limiting plate 10 is in contact with the inner wall of the isolation cylinder 6, and is used to block the rotating shaft 8 and the isolation cylinder 6; a motor 7 is bolted to the mounting shell 3; the output shaft of the motor 7 is fixedly connected to the rotating shaft 8; twenty stirring rods 9 are fixedly connected to the rotating shaft 8, the stirring rods 9 are located in the fermentation tank 2, the stirring rods 9 are arranged as a hollow structure, and each stirring rod 9 is provided with twelve through holes arranged up and down; four first connecting pipes 11 in an annular array are passed through the mounting shell 3, and the first connecting pipes 11 are fixedly connected to the isolation cylinder 6; all the first connecting pipes 11 are commonly connected to the first nozzle 12; the fermentation tank 2 is connected to a discharge pipe 13; the fermentation tank 2 is connected to a second connecting pipe 14, and the second connecting pipe 14 is connected to the rotating shaft 8; the fermentation tank 2 is connected to a feed pipe 15.

[0028] The power assembly includes an electric slide rail 4 and an electric slider 5; two symmetrically arranged electric slide rails 4 are bolted to the mounting shell 3; an electric slider 5 is slidably connected to each electric slide rail 4; and all the electric sliders 5 are fixedly connected to the isolation tube 6.

[0029] A filter 16 is also included; the fermentation tank 2 is connected to the filter 16 .

[0030] A rubber ring is provided between the isolation cylinder 6 and the fermentation tank 2 to seal the gap between the isolation cylinder 6 and the fermentation tank 2 .

[0031] An inner concave structure is arranged at the position where the fermentation tank 2 is connected to the discharge pipe 13, so as to guide the fermented drugs and drug residues.

[0032] A brush is provided inside the isolation tube 6 for cleaning the medicine residue on the stirring rod 9 .

[0033] The stirring rod 9 is made of metal material at one end close to the rotating shaft 8 , and the rest of the stirring rod 9 is made of soft rubber material to prevent the stirring rod 9 from being pushed by the insulating tube 6 and coming into close contact with the rotating shaft 8 .

[0034] A rubber valve 9001 is provided in each through hole of the stirring rod 9 to block the medicine.

[0035] The first nozzle 12 is in close contact with the inner wall of the fermentation tank 2 and is used to scrape off the drug residue remaining on the inner wall of the fermentation tank 2 .

[0036] First, the staff uses an external conveying device to inject the medicine to be fermented into the fermentation tank 2 through the feed pipe 15, and then the staff uses a sealing plug to block the feed pipe 15. Then the staff uses an external gas injection device to connect with the second connecting pipe 14, and then the staff controls the motor 7 to drive the rotating shaft 8 to rotate, and the rotating shaft 8 drives the stirring rod 9 to rotate, and mixes the medicine in the fermentation tank 2 by stirring. In the process of stirring the medicinal materials by the stirring rod 9, the external gas injection device is controlled to operate at the same time, and oxygen is injected into the rotating shaft 8 through the second connecting pipe 14. Then the oxygen enters the stirring rod 9 through the rotating shaft 8 and is sprayed out through the through hole opened on the stirring rod 9, so that the medicine is mixed evenly and the dissolved oxygen is increased, so as to facilitate the fermentation of the medicine. It should be known that in the process of drug fermentation, In the process, oxygen is often introduced to enhance the effect of drug fermentation, and during the process of introducing oxygen, the waste gas generated in the fermentation process is filtered through the filter 16 to avoid pollution of the external environment. After the drug fermentation is completed, the staff uses an external discharge device to connect with the discharge pipe 13 to discharge the drug in the fermentation tank 2. It should be noted that before the external discharge device is connected with the discharge pipe 13, the staff needs to pull out the built-in sealing plug on the discharge pipe 13. When the drug is discharged, the staff first removes the discharge device connected with the discharge pipe 13, and then uses an external waste collection device to connect with the discharge pipe 13, and then the staff uses an external pump to connect with the first connecting pipe 11, and then controls the external pump to operate and inject water into the first connecting pipe 11. The water then enters the first nozzle 12 and is sprayed out through the first nozzle 12 to rinse the inner wall of the fermentation tank 2 and the stirring rod 9. During the process of the water sprayed from the first nozzle 12 to rinse the inner wall of the fermentation tank 2, part of the water flow carries the drug residue on the inner wall of the fermentation tank 2 and splashes back on the stirring rod 9. The stirring rod 9 is originally arranged in a staggered distribution and is difficult to clean. The drug residue splashed on the stirring rod 9 by flushing the inner wall of the fermentation tank 2 undoubtedly increases the difficulty of cleaning the stirring rod 9. Therefore, when the water sprayed from the first nozzle 12 is used to rinse the inner wall of the fermentation tank 2 and the stirring rod 9, the electric slider 5 is controlled to slide downward on the electric slide rail 4, and the electric slider 5 drives the isolation cylinder 6 to move downward. The isolation cylinder 6 moves downward to squeeze the stirring rod 9, so that the stirring rod 9 bends downward and enters the isolation cylinder 6 until Until the isolation cylinder 6 contacts with the bottom of the fermentation tank 2, since only two-thirds of the structure of the stirring rod 9 is made of soft rubber material, the stirring rod 9 bent downward will not fit the rotating shaft 8, and at the same time, the isolation cylinder 6 drives the first connecting pipe 11 and the first nozzle 12 to move downward, and the edge of the first nozzle 12 scrapes the residual drug residue on the inner wall of the fermentation tank 2, and at the same time, the first nozzle 12 sprays water to wash the residual drug residue on the inner wall of the fermentation tank 2. Therefore, in the cleaning process, since the stirring rod 9 is wrapped by the isolation cylinder 6, the drug residue attached to the inner wall of the fermentation tank 2 is prevented from splashing back on the stirring rod 9 when cleaning by flushing. At the same time, the isolation cylinder 6 moves downward to drive the first nozzle 12 to move downward, so that the first nozzle 12 can scrape the inner wall of the fermentation tank 2 while flushing the inner wall of the fermentation tank 2.Thus, the first nozzle 12 scrapes and washes the inner wall of the fermentation tank 2, which is beneficial to improve the cleaning effect and avoid the problem that the drug residues tightly attached to the inner wall of the fermentation tank 2 are difficult to clean only by water flushing. The cleaned drug residues and water are discharged to the external waste collection device through the discharge pipe 13.

[0037] Furthermore, after the isolation cylinder 6 wraps around the stirring rod 9, the staff removes the gas injection device connected to the second connecting pipe 14, and then uses an external water injection device to connect to the second connecting pipe 14, and then controls the water injection device to operate, injects water into the second connecting pipe 14, and then the water enters the rotating shaft 8 through the second connecting pipe 14, and then enters the stirring rod 9 through the rotating shaft 8, and is sprayed out through the through hole opened on the stirring rod 9, so that the water enters the space formed by the fermentation tank 2, the isolation cylinder 6 and the limit plate 10, and at the same time controls the motor 7 to drive the rotating shaft 8 and the stirring rod 9 to rotate, and cooperates with the bristles of the isolation cylinder 6 to clean the residual medicinal materials on the rotating shaft 8 and the stirring rod 9, and at the same time controls the electric slide 5 to move up and down on the electric slide rail 4 The reciprocating movement drives the isolation cylinder 6 to move reciprocatingly up and down. During the movement of the isolation cylinder 6, the sewage is discharged through the gap between the isolation cylinder 6 and the fermentation tank 2, and during the up and down movement, the bent stirring rod 9 is rubbed so that the residual medicinal residue on the stirring rod 9 can be better cleaned up. That is, the isolation cylinder 6 is used to wrap the stirring rod 9 to reduce the cleaning space of the stirring rod 9. That is, during the cleaning process, the water flow impact effect on the stirring rod 9 is enhanced, so that the residual medicinal residue can be better washed off, thereby realizing the cleaning of the stirring rod 9. After the cleaning of the stirring rod 9 is completed, the electric slider 5 is controlled to slide upward on the electric slide rail 4, and the electric slider 5 drives the isolation cylinder 6 to move upward and reset.

[0038] It should be noted that when water is injected into the space formed by the fermentation tank 2, the isolation cylinder 6 and the limit plate 10 through the second connecting pipe 14 to clean the stirring rod 9, and as the isolation cylinder 6 moves back and forth up and down to discharge sewage through the gap between the isolation cylinder 6 and the fermentation tank 2, the water used to clean the stirring rod 9 is also used to rinse the medicinal residue attached to the stirring rod 9 when the bristles are used to clean the stirring rod 9, and then the medicinal residue attached to the stirring rod 9 when the bristles are used to clean the stirring rod 9 is discharged along with the sewage through the gap between the isolation cylinder 6 and the fermentation tank 2.

[0039] Example 2

[0040] On the basis of the above-mentioned embodiment 1, Figure 5-Figure 6 As shown, a cleaning assembly is also included, which includes a third connecting pipe 101 and a second nozzle 102; four third connecting pipes 101 in an annular array are passed through the mounting shell 3; all third connecting pipes 101 are commonly connected to the second nozzle 102; and the second nozzle 102 is fixedly connected to the fermentation tank 2.

[0041] The water spray port of the second nozzle 102 is tilted toward the isolation tube 6 to clean the medicine residue on the isolation tube 6 .

[0042] While the electric slider 5 drives the isolation tube 6 to move downward, an external pump is used to connect with the third connecting pipe 101, and then water is injected into the third connecting pipe 101 through the external pump. Then the water enters the second nozzle 102 through the third connecting pipe 101 and is sprayed out through the second nozzle 102. The sprayed water is used to flush the stirring rod 9, thereby reducing the difficulty of subsequent cleaning of the stirring rod 9. During this process, the stirring rod 9 is deformed and bent downward due to the squeezing of the isolation tube 6 which moves downward step by step, that is, the stirring rod 9 is gradually flushed through the second nozzle 102. Driven by the water flow, the medicine residue can flow downward along the curved shape of the stirring rod 9. After the isolation tube 6 completely wraps the stirring rod 9, the water sprayed from the second nozzle 102 flushes the medicine residue attached to the outer surface of the isolation tube 6, thereby preventing the medicine residue from entering the mounting shell 3 during the subsequent resetting process of the isolation tube 6.

[0043] The above is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art can easily think of changes or substitutions within the technical scope disclosed by the present invention, which should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims

1. A drug fermentation device for targeted release encapsulation technology, comprising a support (1) and a fermentation tank (2); the support (1) is connected to the fermentation tank (2); the characteristics are: The fermentation tank (2) further comprises a mounting shell (3), an isolating cylinder (6), a motor (7), a rotating shaft (8), a stirring rod (9), a limiting plate (10), a first connecting pipe (11), a first nozzle (12), a discharge pipe (13), a second connecting pipe (14), a feeding pipe (15) and a power assembly; the fermentation tank (2) is connected to the mounting shell (3); the mounting shell (3) is connected to the power assembly; the power assembly is connected to the isolating cylinder (6); the power assembly is used to drive the isolating cylinder (6) to move; the mounting shell (3) is provided with a rotating shaft (8), the rotating shaft (8) passes through the isolating cylinder (6) and the fermentation tank (2) and is rotatably connected to the bottom of the fermentation tank (2), and the rotating shaft (8) is arranged in a hollow structure; the rotating shaft (8) is fixedly connected to the limiting plate (10) for sealing the isolating cylinder (6) and the mounting shell (3), and the limiting plate (10) is connected to the isolating cylinder (6). The mounting shell (3) is fixedly connected to the inner wall of the isolation cylinder (6); a motor (7) is fixedly connected to the mounting shell (3); the output shaft of the motor (7) is fixedly connected to the rotating shaft (8); a plurality of stirring rods (9) are fixedly connected to the rotating shaft (8), the stirring rods (9) are located in the fermentation tank (2), the stirring rods (9) are arranged as a hollow structure, and each stirring rod (9) is provided with a plurality of through holes for conveying oxygen and water; a plurality of first connecting pipes (11) are passed through the mounting shell (3), the first connecting pipes (11) are fixedly connected to the isolation cylinder (6); all the first connecting pipes (11) are commonly connected to a first nozzle (12); a discharge pipe (13) is connected to the fermentation tank (2); a second connecting pipe (14) is connected to the fermentation tank (2), the second connecting pipe (14) is connected to the rotating shaft (8); and a feed pipe (15) is connected to the fermentation tank (2).

2. The drug fermentation equipment for targeted release encapsulation technology according to claim 1, characterized in that: It also includes a filter (16); the fermentation tank (2) is connected to the filter (16) for filtering waste gas.

3. The drug fermentation equipment for targeted release encapsulation technology according to claim 1, characterized in that: A rubber ring is provided between the isolation cylinder (6) and the fermentation tank (2).

4. The drug fermentation equipment for targeted release encapsulation technology according to claim 1, characterized in that: An inner concave structure is provided at the position where the fermentation tank (2) is connected to the discharge pipe (13).

5. The drug fermentation equipment for targeted release encapsulation technology according to claim 1, characterized in that: Brush hair is arranged inside the isolation cylinder (6).

6. The drug fermentation equipment for targeted release encapsulation technology according to claim 1, characterized in that: The stirring rod (9) is made of metal material at one end close to the rotating shaft (8), and the rest of the stirring rod (9) is made of soft rubber material.

7. The drug fermentation equipment for targeted release encapsulation technology according to claim 1, characterized in that: A rubber valve (9001) is arranged in each through hole of the stirring rod (9).

8. A drug fermentation device for targeted release encapsulation technology according to any one of claims 1 to 7, characterized in that: The first nozzle (12) is tightly fitted to the inner wall of the fermentation tank (2).

9. The drug fermentation equipment for targeted release encapsulation technology according to claim 8, characterized in that: It also includes a cleaning assembly, which includes a third connecting pipe (101) and a second nozzle (102); a plurality of third connecting pipes (101) are provided on the mounting shell (3); all the third connecting pipes (101) are commonly connected to the second nozzle (102); and the second nozzle (102) is fixedly connected to the fermentation tank (2).

10. The drug fermentation equipment for targeted release encapsulation technology according to claim 9, characterized in that: The water spray port of the second spray head (102) is arranged to be inclined toward the isolation cylinder (6).

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