Plant polysaccharide functional beverage for perioperative period and preparation method thereof

Abstract

The invention discloses a plant polysaccharide functional beverage used in the perioperative period and a preparation method thereof, and relates to the technical field of functional beverages, the key point of the technical scheme is that the beverage is prepared by adding 16-20g of astragalus polysaccharide, 2-6g of honey and 0.3-0.6 g of sodium citrate into every 200mL of purified water, and the invention also discloses a preparation method of the functional beverage. The functional drink prepared by the invention can effectively improve postoperative insulin resistance of a patient while effectively supplying energy, improve immunity, protect organ functions and promote rapid recovery of the patient. The plant polysaccharide functional beverage is simple in production process, wide in raw material source, relatively low in equipment requirement and convenient for large-scale industrial production.

Description

Technical Field

[0001] The invention relates to the technical field of functional beverages, and more specifically, to a plant polysaccharide functional beverage for perioperative period and a preparation method thereof. Background Art

[0002] Surgical stress produces insulin resistance, which is affected by factors such as the size of the surgery and the length of fasting and abstinence. Insulin resistance increases the incidence of postoperative complications, including infection and organ dysfunction, leading to delayed postoperative recovery, increased hospitalization and medical expenses. In order to improve postoperative insulin resistance, increase the comfort of surgical patients, and promote rapid recovery of patients, the preoperative fasting and abstinence guidelines have been revised in recent years. Domestic and international fasting and abstinence guidelines recommend taking clear drinks or carbohydrates orally 2-4 hours before surgery.

[0003] Studies have shown that preoperative oral carbohydrates can prevent or significantly improve postoperative insulin resistance, maintain nitrogen balance, reduce postoperative thirst and hunger, reduce inflammatory responses, and produce multiple organ protective effects. In previous studies, the research team found that preoperative carbohydrates mainly play an organ protective role by stimulating the release of intestinal hormones (especially glucagon-like peptide 1, GLP-1). After the GLP-1 receptor is stimulated, it activates the PI3K / Akt signaling pathway to produce a wide range of physiological effects, including promoting insulin release and utilization, improving insulin resistance, inhibiting inflammatory responses, reducing endoplasmic reticulum stress responses, and protecting organs such as the cardiovascular and nervous systems. Carbohydrates in food are one of the main stimulating factors for the release of GLP-1 by intestinal L cells. The polysaccharide components in carbohydrates and their stability are particularly important. In recent years, the role of plant polysaccharides in the field of metabolism has received increasing attention. A variety of plant polysaccharides have been shown to improve insulin resistance and multiple organ protective effects in patients with diabetes.

[0004] Astragalus has the effects of improving immunity, replenishing qi and raising yang, strengthening the exterior and stopping sweating, promoting diuresis and reducing swelling, promoting fluid and nourishing blood, relieving stagnation and relieving arthritis, removing toxins and draining pus, and healing sores and promoting tissue regeneration. It is very suitable for perioperative use. Astragalus polysaccharide is the most important natural active ingredient of Astragalus and is a typical representative of plant polysaccharides. It has the characteristics of improving insulin resistance, regulating blood sugar, enhancing immunity, anti-fatigue, and anti-oxidation.

[0005] There are many studies and questions about oral carbohydrate drinks before surgery. Some of the questions include:

[0006] 1. Currently, most preoperative drinks are carbohydrate drinks for special medical purposes, which are mainly made of maltodextrin, crystalline fructose and other polysaccharide ingredients. Compared with general drinks, they have no obvious advantages, are expensive, and have poor patient acceptance. The clinical application of drinking carbohydrate drinks 2 hours before surgery is also poor;

[0007] 2. There is no recommendation for oral plant polysaccharide or Chinese medicine polysaccharide beverages for surgical patients before surgery. Several patents have disclosed astragalus compound functional beverages for improving immunity. These patents have the following disadvantages:

[0008] (1) Preparation: The preparation process is complicated. Most of them use astragalus compound jujube, wolfberry, hawthorn, etc. to boil or use powder. The raw material composition is complex, the taste is not good or bitter, and the polysaccharide content and activity are unclear;

[0009] (2) Implementation: Due to the complex ingredients and uncertain oral dosage, it is not conducive to the application and promotion of perioperative use and research. Summary of the invention

[0010] The purpose of the present invention is to provide a plant polysaccharide functional beverage for perioperative period and a preparation method thereof, wherein the prepared functional beverage can effectively improve the patient's postoperative insulin resistance, improve immunity, protect organ function, and promote rapid recovery of the patient while effectively providing energy. The plant polysaccharide functional beverage has a simple production process, a wide range of raw materials, relatively low equipment requirements, and is convenient for large-scale industrial production.

[0011] The above technical purpose of the present invention is achieved through the following technical scheme: a plant polysaccharide functional beverage for perioperative period, which is composed of astragalus polysaccharide, honey, sodium citrate and purified water.

[0012] The present invention is further configured as follows: the plant polysaccharide functional beverage is composed of: 200 mL of pure water, 16-20 g of astragalus polysaccharide, 2-6 g of honey, and 0.3-0.6 g of sodium citrate.

[0013] The present invention is further configured as follows: the weight ratio of the astragalus polysaccharide to the honey is: astragalus polysaccharide:honey=2:1-5:1.

[0014] The present invention is further configured as follows: the purity of the astragalus polysaccharide is above 90%, and the activity is above 2.0.

[0015] The present invention also provides a method for preparing a plant polysaccharide functional beverage for perioperative period:

[0016] The following steps are involved:

[0017] S1. Preparation: Mix astragalus polysaccharide, honey and sodium citrate;

[0018] S2. Homogenization: The prepared beverage is homogenized in a homogenizer and clarified and filtered;

[0019] S3. Filling, sterilization, and cooling: Sterilize the filling container and bottle cap, fill the homogenized liquid while it is hot, screw the cap to seal, sterilize in a water bath, cool, and obtain the finished product.

[0020] The present invention is further configured as follows: the mixing temperature in S1 is 80-100°C.

[0021] The present invention is further configured as follows: the homogenization pressure in S2 is 25 MPa and the temperature is 60-70°C.

[0022] The present invention is further configured as follows: the sterilization in S3 is performed in a 100° C. water bath for 15 minutes.

[0023] In summary, the present invention has the following beneficial effects:

[0024] 1. The plant polysaccharide functional beverage prepared by the present invention has simple ingredients, clear efficacy and good effect. Astragalus polysaccharide is a key component, which has the effects of improving metabolism, regulating blood sugar, improving immunity, promoting diuresis and reducing swelling, promoting body fluid and nourishing blood, detoxifying and draining pus, and healing sores and promoting tissue regeneration, and is suitable for drinking by surgical patients. At the same time, astragalus polysaccharide is different from astragalus, and its ingredients are single, purity and activity are stable and adjustable, side effects are small, and there are no bitterness and other advantages. Honey cooperates with the effect of astragalus to moisten the lungs and relieve cough, moisten the intestines and relieve constipation, and has a seasoning effect, which improves the taste of astragalus polysaccharide. Sodium citrate can adjust acidity, supplement the daily electrolytes required by the human body, and promote intestinal glucose transport. While effectively supplying energy, this drink can effectively improve patients' postoperative insulin resistance, improve immunity, protect organ function, and promote rapid recovery of patients.

[0025] 2. The polysaccharide beverage does not have the bitter taste and fishy smell of traditional Chinese medicine, and has a good taste. Astragalus polysaccharide does not contain other impurities of astragalus. The prepared beverage is colorless and transparent, with a slightly fragrant and slightly sweet taste. Adding a certain amount of honey can further flavor and color the beverage while increasing the efficacy and improving the taste of the beverage.

[0026] In addition to the basic steps of mixing, filling, sterilization, etc., the method for preparing the plant polysaccharide functional beverage of the present invention also processes the plant polysaccharide functional beverage by a homogenizer to homogenize the polysaccharide components, prevent the product from stratification and precipitation, and further ensure the stability of the product. The production process of the plant polysaccharide functional beverage is simple, the raw material source is wide, the equipment requirements are relatively low, and it is convenient for large-scale industrial production. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 The change in plasma GLP-1 concentration of rats after intragastric administration of Astragalus polysaccharide in Comparative Example 1 of the present invention;

[0028] Figure 2 It is a comparison of plasma GLP-1 concentrations in rats after intragastric administration in Comparative Example 2 of the present invention;

[0029] Figure 3Ultrasound images of the gastric antrum after oral administration of 200 mL of purified water and astragalus polysaccharide solution of the present invention (A, B, C, and D represent ultrasound images of the gastric antrum before oral administration, immediately after oral administration, 1 hour after oral administration, and 2 hours after oral administration, respectively, and the red arrow indicates the position of the gastric antrum)

[0030] Figure 4 The invention discloses a preparation process of the plant polysaccharide functional beverage. DETAILED DESCRIPTION

[0031] The following is combined with Figure 1-4 The present invention is described in further detail.

[0032] Example 1: A plant polysaccharide functional beverage for perioperative period and a preparation method thereof, wherein the beverage is composed of: adding 20 g of astragalus polysaccharide, 4 g of honey and 0.6 g of sodium citrate to every 200 mL of pure water.

[0033] The processing technology is as follows:

[0034] a. Preparation: Mix astragalus polysaccharide, honey, sodium citrate, etc. at a temperature of 80-100°C.

[0035] b. Homogenization: Homogenize the prepared beverage in a homogenizer at a homogenization pressure of 25MPa and a temperature of 60-70°C, and perform clarification filtration.

[0036] c. Filling, sterilization and cooling: sterilize the filling container and bottle cap, fill the homogenized liquid while it is hot, screw the cap to seal, sterilize in a water bath, cool, and obtain the finished product.

[0037] Example 2: An astragalus polysaccharide functional beverage for perioperative use, the composition of the beverage being: adding 16 g of astragalus polysaccharide, 8 g of honey, and 0.4 g of sodium citrate to every 200 mL of pure water.

[0038] The processing technology is as follows:

[0039] a. Preparation: Mix astragalus polysaccharide, honey, sodium citrate, etc. at a temperature of 80-100°C.

[0040] b. Homogenization: Homogenize the prepared beverage using a homogenizer at a temperature of 60-70°C and a homogenization pressure of 25MPa, and perform clarification and filtration.

[0041] c. Filling, sterilization and cooling: sterilize the filling container and bottle cap, fill the homogenized liquid while it is hot, screw the cap to seal, sterilize in a water bath, cool, and obtain the finished product.

[0042] Comparative Example 1: 16 SD rats were randomly divided into two groups. They were fasted and deprived of water for 12 hours before the experiment. Blood was collected from the inner canthus of the eye once before the experiment to record the basic value. Then, at the beginning of the experiment, 2 ml of the following solutions were gavaged: normal saline (control group) and astragalus polysaccharide solution of Example 1 (astragalus group). Glucagon-like peptide-1 (GLP-1) was measured by blood sampling from the inner canthus of the eye at 5, 10, 20, 30, 45, 60, 90, 120, and 180 minutes after gavage. The results showed that Figure 1 As shown in the results, the plasma GLP-1 concentration of rats in the Astragalus group was significantly higher than that of normal saline at 5, 10, 20, and 60 minutes after intragastric administration. GLP-1 has the effects of improving insulin resistance and protecting multiple organs, and its protective effects can last for several days. The experimental results show that the Astragalus polysaccharide solution has a good organ protective effect when used before surgery.

[0043] Comparative Example 2: Based on Comparative Example 1, this experiment selected the peak point of GLP-1 release after intragastric administration to conduct a comparative study on the Astragalus of Example 1 and Example 2. 32 SD rats were selected and randomly divided into four groups. After fasting for 12 hours before the experiment, 2 ml of the following solutions were used for intragastric administration: intragastric administration only (blank control), normal saline (placebo group), Astragalus solution of Example 1 (Astragalus polysaccharide 1 group), and Astragalus solution of Example 2 (Astragalus polysaccharide 2 group). At 5, 20, and 60 minutes after intragastric administration, blood was collected from the tail vein to measure glucagon-like peptide-1 (GLP-1). The results showed that Figure 2 As shown, both Astragalus solutions can significantly increase the release of GLP-1 compared with the blank control and saline. Although there is no statistical difference in the GLP-1 concentration of the two Astragalus solutions at each time point, the GLP-1 release of the Astragalus solution in Example 1 is slightly lower than that of Example 2 at 5 minutes after intragastric administration, but it is higher at 60 minutes after intragastric administration. The experimental results show that both Astragalus polysaccharide solutions can promote the release of GLP-1 well, and the change in the polysaccharide ratio can change the GLP-1 release amount and release curve.

[0044] Comparative Example 3: In order to observe the safety of oral administration of Astragalus polysaccharide solution before surgery, we observed the ultrasound images of the gastric antrum after oral administration of Astragalus polysaccharide solution on human body. Ultrasound scans of the gastric antrum were performed in supine and right side decubitus positions before, immediately after, 1 hour after, and 2 hours after oral administration of 200 ml of purified water and Astragalus polysaccharide solution of Example 1, and qualitative evaluation was performed. The results showed that Figure 3As shown in the figure, pure water empties the stomach faster. Due to its viscous nature, the gastric antrum expands immediately after oral administration, and ultrasound shows an isoechoic oval shadow; 1 hour after oral administration, it shows a "starry sky" phenomenon with low-echo liquid shadows mixed with high-echo gas images; 2 hours after oral administration, it returns to the phenomenon before oral administration, which is manifested as a smaller gastric antrum and an oval "bull's eye sign". The results show that the gastric antrum can achieve gastric emptying 2 hours after oral administration, and oral administration of the astragalus polysaccharide solution 2 hours before surgery will not cause the risk of reflux aspiration, which is safe and reliable.

[0045] This specific embodiment is merely an explanation of the present invention and is not a limitation of the present invention. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed. However, as long as they are within the scope of the claims of the present invention, they are protected by the patent law.

Claims

1. A plant polysaccharide functional beverage for perioperative period, characterized by: The plant polysaccharide functional beverage consists of astragalus polysaccharide, honey, sodium citrate and purified water.

2. The plant polysaccharide functional beverage according to claim 1, characterized in that: The plant polysaccharide functional beverage is composed of: 200 mL of purified water, 16-20 g of astragalus polysaccharide, 2-6 g of honey, and 0.3-0.6 g of sodium citrate.

3. The plant polysaccharide functional beverage according to any one of claims 1 or 2, characterized in that: The weight ratio of the astragalus polysaccharide to the honey is: astragalus polysaccharide:honey=2:1-5:

1.

4. The plant polysaccharide functional beverage according to any one of claims 1 or 2, characterized in that: The purity of the astragalus polysaccharide is above 90%, and the activity is above 2.

0.

5. The method for preparing the plant polysaccharide functional beverage according to any one of claims 1 or 2, characterized in that: The following steps are involved: S1. Preparation: Mix astragalus polysaccharide, honey and sodium citrate; S2. Homogenization: The prepared beverage is homogenized in a homogenizer and clarified and filtered; S3. Filling, sterilization, and cooling: Sterilize the filling container and bottle cap, fill the homogenized liquid while it is hot, screw the cap to seal, sterilize in a water bath, cool, and obtain the finished product.

6. The method for preparing the plant polysaccharide functional beverage according to claim 5, characterized in that: The mixing temperature in S1 is 80-100°C.

7. The method for preparing the plant polysaccharide functional beverage according to claim 5, characterized in that: The homogenization pressure in S2 is 25 MPa and the temperature is 60-70°C.

8. The method for preparing the plant polysaccharide functional beverage according to claim 5, characterized in that: The sterilization in S3 is carried out in a water bath at 100° C. for 15 minutes.

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