Temperature-triggered burn dressing and preparation method thereof

Abstract

A temperature-triggered burn dressing comprises: a first release paper, a second release paper, a flash-steamed nonwoven fabric, a PVA-PNIPAM hydrogel, ammonium nitrate powder, a sodium alginate carrier, a first carrier, a second carrier, and a third carrier; a fixed area is formed at a central portion of the top surface of the flash-steamed nonwoven fabric, and adhesive areas are formed at other portions of the top surface of the flash-steamed nonwoven fabric; the bottom surface of the sodium alginate carrier is fixed to the fixed area; the sodium alginate carrier comprises a first carrier, a second carrier, and a third carrier; the bottom surface of the first carrier is fixed to the fixed area, the bottom surface of the second carrier is fixed to the top surface of the first carrier; the ammonium nitrate powder is applied to a portion between the first and second carriers, and the bottom surface of the third carrier is fixed to the fixed area. The present invention can be stored at room temperature and, upon contact with a wound, refrigerates the wound internally through warm contact to rapidly cool the wound.

Description

Technical Field

[0001] The invention relates to a medical dressing, belongs to the field of burn dressings, and in particular to a temperature-triggered burn dressing and a preparation method thereof. Background Art

[0002] Burns and scalds are accidental injuries that we often encounter in life, such as scalds from boiling water and kitchen fire. After a burn or scald occurs, the damage does not stop immediately after moving away from the heat source. The residual heat on the skin tissue will further damage the wound and deepen the damage. Therefore, the first thing to do after a burn or scald is to quickly lower the skin surface temperature and remove the residual heat. Burn dressings are medical supplies used to manage and treat burn wounds. Their main functions are to protect the wound, promote healing, reduce the risk of infection, and relieve pain.

[0003] Chinese patent application number 202110530354.7, filed on May 4, 2021, discloses a hydrogel dressing for first aid and treatment of burn wounds. Specifically, the invention provides a use of the hydrogel dressing, namely, for preparing a medical product for first aid treatment of burn wounds or wounds. However, the technology has the following defects:

[0004] In the comparative documents, the dressing can be carried around and is easy to store. In emergency situations such as burns, the hydrogel can be brought into contact with the wound to absorb heat from the wound, reduce the wound temperature and promote wound healing. During specific use, the temperature of the hydrogel itself is basically maintained at room temperature. However, the temperature drop at the wound is limited by the hydrogel releasing water when heated to absorb heat from the wound, which only drops by 4-7°C. It is difficult to maintain the temperature of the wound in a suitable range below room temperature. Because the residual heat at the wound cannot be contained, the residual heat will continue to damage the burn wound tissue. In order to ensure the cooling effect and contain the damage to the burn wound tissue caused by the residual heat, the temperature of the dressing itself needs to be kept below room temperature for a long time to maintain the low temperature of the dressing. This method will not only limit the use of the dressing, but also easily lead to waste of resources and increase costs.

[0005] The information disclosed in this background technology section is only intended to increase understanding of the overall background of the application and should not be considered as an admission or any form of suggestion that the information constitutes the prior art already known to ordinary technicians in this field. Summary of the Invention

[0006] The purpose of the present invention is to overcome the problem in the prior art that the wound temperature cannot be quickly reduced after the dressing absorbs heat upon warm contact, and to provide a temperature-triggered burn dressing and a preparation method that can quickly reduce the wound temperature upon warm contact and heat absorption.

[0007] To achieve the above objectives, the technical solution of the present invention is: a temperature-triggered burn dressing, comprising: a first release paper, a second release paper, a flash-steamed nonwoven fabric, a PVA-PNIPAM hydrogel, ammonium nitrate powder, a sodium alginate carrier, a first carrier, a second carrier, and a third carrier;

[0008] A fixed area is formed at the center of the top surface of the flash steamed nonwoven fabric, and an adhesive area is formed at other positions on the top surface of the flash steamed nonwoven fabric. The bottom surface of the sodium alginate carrier is fixed at the fixed area. The sodium alginate carrier includes a first carrier, a second carrier and a third carrier. The bottom surface of the first carrier is fixed at the fixed area, and the bottom surface of the second carrier is fixed to the top surface of the first carrier. The ammonium nitrate powder is applied to the position between the first carrier and the second carrier, and the bottom surface of the third carrier is fixed at the fixed area. The outer side of the first carrier is fixed to the inner wall of the third carrier near its lower end surface, and the outer side of the second carrier is fixed to the inner wall of the third carrier near its lower end surface. At the end surface, a placement area located on the upper inner side of the third carrier is formed on the top surface of the second carrier, the PVA-PNIPAM hydrogel is fixed in the placement area, the bottom surface of the PVA-PNIPAM hydrogel is adhered to the top surface of the second carrier, the periphery of the PVA-PNIPAM hydrogel is adhered to the inner wall of the third carrier, the PVA-PNIPAM hydrogel, the second carrier, ammonium nitrate powder, the first carrier and the flash-steamed non-woven fabric are distributed in sequence from top to bottom, the adhesion area is adhered with glue, the bottom surface of the first release paper is attached to the top surface of the glue, and the bottom surface of the second release paper is attached to the top surface of the PVA-PNIPAM hydrogel.

[0009] In step S2, the length, width and height of the first carrier are 10 cm, 10 cm and 0.2 cm respectively, the length, width and height of the first carrier are 10 cm, 10 cm and 0.2 cm respectively, the first carrier and the second carrier have the same size, and the length, width and height of the placement area are 10 cm, 10 cm and 0.2 cm respectively.

[0010] The length, width and height of the PVA-PNIPAM hydrogel are 10 cm, 10 cm and 0.2 cm respectively, and the size of the PVA-PNIPAM hydrogel is adapted to the size of the placement area.

[0011] The length and width of the flash-steamed nonwoven fabric are both 14 cm, and the width (d) of the adhesive area is 2 cm.

[0012] A method for preparing a temperature-triggered burn dressing, comprising the following steps:

[0013] S1. First, 10-30 parts by weight of polyvinyl alcohol and 90-150 parts by weight of deionized water are placed in a container, and then the container, the polyvinyl alcohol and the deionized water are continuously heated and stirred at 90° C. using a heating device. After stirring until the polyvinyl alcohol in the container is completely dissolved, the container is allowed to cool to room temperature to obtain a polyvinyl alcohol solution;

[0014] S2. Subsequently, 0.06-0.12 parts by weight of N,N-methylenebisacrylamide, 0.3-0.5 parts by weight of ammonium persulfate, and 18-27 parts by weight of N-isopropylacrylamide are sequentially added to the cooled polyvinyl alcohol solution, and the mixture is mixed and stirred. The polyvinyl alcohol solution is stirred until the N-isopropylacrylamide is completely dissolved to obtain a preliminary mixed solution.

[0015] S3, then nitrogen is introduced into the preliminary mixed solution, and 0.0002-0.0005 parts by weight of tetramethylethylenediamine is added to the preliminary mixed solution, and the mixture is stirred for five minutes under ventilation to obtain a final mixed solution;

[0016] S4, then injecting the final mixed solution into a sealed molding mold for encapsulation, and placing the mold at 8°C for 24 hours to finally obtain the PVA-PNIPAM hydrogel;

[0017] S5, first applying 50-100 parts by weight of ammonium nitrate powder on the surface of the first carrier to obtain a starting carrier, then applying environmentally friendly wood glue on the edge of the surface, and then covering the second carrier on the first carrier to cover the surface to form a preliminary carrier;

[0018] S6, then applying environmentally friendly wood glue on the periphery of the preliminary carrier, and placing it into the third carrier. After the environmentally friendly wood glue is air-dried, the first carrier, the second carrier and the third carrier form a sodium alginate carrier;

[0019] S7, firstly adhere the PVA-PNIPAM hydrogel obtained according to step S4 to the placement area of ​​the sodium alginate carrier according to its own viscosity to obtain an initial dressing;

[0020] S8. The initial dressing is then fixed to the fixed area of ​​the flash nonwoven fabric using environmentally friendly wood glue, and then adhesive is applied to the sticky area of ​​the flash nonwoven fabric. The first release paper is attached to the adhesive and the second release paper is attached to the PVA-PNIPAM hydrogel, respectively, to obtain the final dressing.

[0021] The amount of the polyvinyl alcohol is 10 parts by weight, the amount of the deionized water is 90 parts by weight, the amount of the N,N-methylenebisacrylamide is 0.0616 parts by weight, the amount of the ammonium persulfate is 0.3 parts by weight, the amount of the N-isopropylacrylamide is 18 parts by weight, the amount of the tetramethylethylenediamine is 0.0002 parts by weight, and the amount of the ammonium nitrate powder is 90 parts by weight.

[0022] In the step S1, the parameter of the heating and stirring is 500-600r / min, in the step S2, the parameter of the mixing and stirring is 500-600r / min, in the step S3, the parameter of the ventilation and stirring is 500-600r / min, in the step S1, the heating and stirring time is greater than 2h, and in the step S2, the mixing and stirring time is greater than 30min.

[0023] In step S5, the starting vector is obtained according to the following steps:

[0024] Step 1: first, lay the first carrier flat on the table, and then use a medicine spoon to take out a certain amount of ammonium nitrate powder and sprinkle it on the surface of the first carrier;

[0025] Step 2: Take another clean cotton swab, and then use the cotton swab to evenly spread the ammonium nitrate powder that has fallen on the above-mentioned first carrier on the surface of the first carrier, allowing the ammonium nitrate powder to adhere to the fiber fluff on the surface of the first carrier to obtain a starting carrier.

[0026] In step S6, the sodium alginate carrier is obtained according to the following steps:

[0027] Step 1: First, select a sodium alginate block with the dimensions of 10.2 cm in length, 10.2 cm in width, and 0.6 cm in height. Then, cut a square hole in the sodium alginate block according to the length and width of the first and second carriers to obtain a third carrier with a hollow interior.

[0028] Step 2: First, apply environmentally friendly wood glue on the periphery of the preliminary carrier, then move the preliminary carrier into the third carrier obtained in the first step, and make the bottom surface of the preliminary carrier flush with the lower end surface of the third carrier. After the environmentally friendly wood glue is air-dried, the preliminary carrier and the third carrier can form a sodium alginate carrier.

[0029] In step S8, the final dressing is obtained according to the following steps:

[0030] Step 1: Apply adhesive to the sticky area of ​​the flash nonwoven fabric;

[0031] Step 2: Prepare a first release paper of the same size as the flash-steamed nonwoven fabric. Cut a hole of the same size in the center of the first release paper according to the length and width of the sodium alginate carrier. Then, pass the first release paper through the hole and attach it to the adhesive area on the adhesive area, completely covering the adhesive area.

[0032] Step 3: First prepare a second release paper of the same size as the sodium alginate carrier, and then attach the second release paper to the PVA-PNIPAM hydrogel based on the second step, so that the second release paper completely covers the PVA-PNIPAM hydrogel and the sodium alginate carrier, and finally obtain the final dressing.

[0033] Compared with the prior art, the present invention has the following beneficial effects:

[0034] 1. A temperature-triggered burn dressing and preparation method of the present invention include: a first release paper, a second release paper, a flash nonwoven fabric, a PVA-PNIPAM hydrogel, ammonium nitrate powder, a sodium alginate carrier, a first carrier, a second carrier, and a third carrier. The sodium alginate carrier includes a first carrier, a second carrier, and a third carrier. The bottom surface of the first carrier is fixed to a fixed area, and the bottom surface of the second carrier is fixed to the top surface of the first carrier. The ammonium nitrate powder is applied to the area between the first carrier and the second carrier. When used, the PVA-PNIPAM hydrogel first contacts the wound. When the temperature of the wound is higher than the critical dissolution temperature of the PVA-PNIPAM hydrogel, the PVA-PNIPAM hydrogel releases water to absorb heat, and then the released water is used to absorb heat. Therefore, the PVA-PNIPAM hydrogel will not release water and absorb heat by reacting with ammonium nitrate powder until the contact temperature reaches its critical dissolution temperature. This feature allows the dressing to be stored at room temperature. At the same time, during the heat absorption process, the heat at the wound is transferred to the dressing under the dual heat absorption of PVA-PNIPAM hydrogel and ammonium nitrate powder, and the temperature of the wound drops rapidly, so that the temperature of the wound is maintained at 10-15°C within 30min-60min, thereby cooling the wound, avoiding deepening the damage to the burn wound tissue, curbing the damage to the burn wound tissue, and allowing the dressing to effectively cool without being kept at a low temperature for a long time. Therefore, this design can be stored at room temperature, and after contacting the wound, the temperature of the wound instantly triggers the internal refrigeration reaction, thereby rapidly cooling the wound.

[0035] 2. In a temperature-triggered burn dressing and preparation method of the present invention, a fixed area is formed at the central position on the top surface of the flash-steamed non-woven fabric, and sticky areas are formed at other positions on the top surface of the flash-steamed non-woven fabric. The bottom surface of the sodium alginate carrier is fixed at the fixed area. When used, the flash-steamed non-woven fabric can maintain its excellent water resistance during use due to its good liquid resistance. At the same time, because the flash-steamed non-woven fabric has the material advantages of small fiber diameter and high monofilament strength, microorganisms must pass through the narrow and tortuous channels formed between the multiple layers of stacked ultrafine fibers to penetrate the flash-steamed non-woven fabric, which gives the flash-steamed non-woven fabric a natural high microbial barrier. Therefore, the outer layer of the dressing made of flash-steamed non-woven fabric is not easily eroded by bacteria and other microorganisms, and can keep the inside of the dressing and the wound clean to a certain extent. Therefore, the protection and antibacterial properties of this design are good, and it has the advantages of protecting the wound from external contamination and delaying wound inflammation.

[0036] 3. In the temperature-triggered burn dressing and preparation method of the present invention, the length and width of the flash nonwoven fabric are both 14 cm, the width (d) of the adhesive area is 2 cm, the adhesive area is adhered with an adhesive, the bottom surface of the first release paper is attached to the top surface of the adhesive, and the length, width and height of the PVA-PNIPAM hydrogel are 10 cm, 10 cm and 0.2 cm respectively. When applied, after a single piece of dressing is covered on the wound, the flash nonwoven fabric adheres to the intact skin area at the edge of the wound through the 2 cm wide adhesive on the adhesive area, which can effectively fix the dressing and improve the dressing during fixation. At the same time, when a single dressing cannot completely cover the wound, multiple dressings are arranged and combined together, and the adhesive areas of the overlapping flash-steamed nonwoven fabrics between adjacent dressings are adhered together by adhesives, so that multiple dressings can be spliced ​​together. The combined multiple dressings can allow multiple PVA-PNIPAM hydrogels to cover a large area of ​​the wound. The 2 cm wide adhesive area and the adhesive on it can not only make the dressing firmly connected to the skin, but also make multiple dressings firm when spliced ​​together. Therefore, this design is firm when connected to the skin, and at the same time, multiple dressings can be combined to adapt to large-area wounds to completely cover the wound.

[0037] 4. A temperature-triggered burn dressing and preparation method of the present invention comprises: S1, heating and stirring polyvinyl alcohol and deionized water to obtain a polyvinyl alcohol solution; S2, sequentially adding N,N-methylenebisacrylamide, ammonium persulfate and N-isopropylacrylamide to the polyvinyl alcohol solution and mixing and stirring to obtain a preliminary mixed solution; S3, adding tetramethylethylenediamine to the preliminary mixed solution and introducing nitrogen to obtain a final mixed solution; S4, pouring the final mixed solution into a mold to obtain a PVA-PNIPAM hydrogel; S5, applying ammonium nitrate powder between a first carrier and a second carrier, and combining them to obtain a preliminary carrier; S6, the first carrier, the second carrier and the third carrier form a hydrogel. Sodium alginate carrier; S7, fix the PVA-PNIPAM hydrogel in the sodium alginate carrier to obtain a preliminary carrier; S8, fix the preliminary carrier on the flash-steamed non-woven fabric to obtain the final carrier. When used, the dressing is prepared according to the above sequence, which is not only easy to operate, but also does not require complicated equipment. The steps are simple and easy to perform, suitable for large-scale production, and the production cost is low, with obvious economic benefits. At the same time, the dressing prepared by the above steps can be instantly cooled and cooled after coming into contact with a temperature higher than the critical dissolution temperature of the PVA-PNIPAM hydrogel, and the cooling effect is good. There is no need to keep the dressing at a low temperature for a long time to effectively cool it. Therefore, this design has the advantages of low production cost, simple preparation, and good use effect.

[0038] 5. In a temperature-triggered burn dressing and preparation method of the present invention, 10 parts by weight of polyvinyl alcohol, 90 parts by weight of deionized water, 0.0616 parts by weight of N,N-methylenebisacrylamide, 0.3 parts by weight of ammonium persulfate, 18 parts by weight of N-isopropylacrylamide and 0.0002 parts by weight of tetramethylethylenediamine are prepared according to steps S1 to S4 to obtain a PVA-PNIPAM hydrogel; S5, 90 parts by weight of ammonium nitrate powder is first applied between the first carrier and the second carrier to form a preliminary carrier; PVA- The PNIPAM hydrogel adheres to the preliminary carrier. During application, the PVA-PNIPAM hydrogel absorbs heat when in contact with the wound. After absorbing heat, the PVA-PNIPAM hydrogel releases 15ml of water. This 15ml of water absorbs heat when reacting with 90 parts by weight of ammonium nitrate powder, which can maintain the temperature of the wound at 10-15°C for 30-60 minutes, thereby preventing the damage to the burn wound tissue from worsening. Therefore, this design has a good heat absorption and cooling effect and a long maintenance time, which can effectively prevent the damage to the burn wound tissue from worsening. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] Figure 1 The figure is a front view of a temperature-triggered burn dressing according to the present invention.

[0040] Figure 2The figure is a schematic diagram of the internal structure of a sodium alginate carrier in a temperature-triggered burn dressing of the present invention.

[0041] Figure 3 This is a schematic diagram of the split structure of the sodium alginate carrier and the flash-steamed non-woven fabric in a temperature-triggered burn dressing of the present invention.

[0042] Figure 4 It is a schematic diagram of the network structure of the PVA-PNIPAM hydrogel in the temperature-triggered burn dressing of the present invention.

[0043] Figure 5 It is a schematic diagram of the surface structure of the first carrier in a temperature-triggered burn dressing of the present invention.

[0044] Figure 6 The present invention is a flow chart of a method for preparing a temperature-triggered burn dressing.

[0045] Figure 7 The present invention is a flow chart of a method for preparing a PVA-PNIPAM hydrogel in a method for preparing a temperature-triggered burn dressing.

[0046] In the figure: flash-steamed nonwoven fabric 1, first release paper 2, sodium alginate carrier 3, second release paper 4, third carrier 5, ammonium nitrate powder 6, first carrier 7, PVA-PNIPAM hydrogel 8, second carrier 9, fixing area 10, sticky area 11, placement area 12, adhesive 13. DETAILED DESCRIPTION

[0047] The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0048] A temperature-triggered burn dressing, comprising: a first release paper 2, a second release paper 4, a flash-steamed nonwoven fabric 1, a PVA-PNIPAM hydrogel 8, ammonium nitrate powder 6, a sodium alginate carrier 3, a first carrier 7, a second carrier 9, and a third carrier 5;

[0049] A fixed area 10 is formed at the center of the top surface of the flash steamed nonwoven fabric 1, and an adhesive area 11 is formed at other positions on the top surface of the flash steamed nonwoven fabric 1. The bottom surface of the sodium alginate carrier 3 is fixed at the fixed area 10. The sodium alginate carrier 3 includes a first carrier 7, a second carrier 9 and a third carrier 5. The bottom surface of the first carrier 7 is fixed at the fixed area 10, and the bottom surface of the second carrier 9 is fixed to the top surface of the first carrier 7. The ammonium nitrate powder 6 is applied to the position between the first carrier 7 and the second carrier 9. The bottom surface of the third carrier 5 is fixed at the fixed area 10. The outer side of the first carrier 7 is fixed to the inner wall of the third carrier 5 near its lower end surface, and the outer side of the second carrier 9 is fixed to the inner wall of the third carrier 5 near its lower end surface. At the lower end surface, a placement area 12 located on the upper inner side of the third carrier 5 is formed on the top surface of the second carrier 9, and the PVA-PNIPAM hydrogel 8 is fixed in the placement area 12. The bottom surface of the PVA-PNIPAM hydrogel 8 is adhered to the top surface of the second carrier 9, and the outer periphery of the PVA-PNIPAM hydrogel 8 is adhered to the inner wall of the third carrier 5. The PVA-PNIPAM hydrogel 8, the second carrier 9, the ammonium nitrate powder 6, the first carrier 7 and the flash-steamed non-woven fabric 1 are distributed in sequence from top to bottom. The adhesive 13 is adhered to the adhesive area 11, the bottom surface of the first release paper 2 is attached to the top surface of the adhesive 13, and the bottom surface of the second release paper 4 is attached to the top surface of the PVA-PNIPAM hydrogel 8.

[0050] The length, width and height of the first carrier 7 are 10 cm, 10 cm and 0.2 cm respectively. The length, width and height of the first carrier 7 are 10 cm, 10 cm and 0.2 cm respectively. The first carrier 7 and the second carrier 9 have the same size. The length, width and height of the placement area 12 are 10 cm, 10 cm and 0.2 cm respectively.

[0051] The length, width and height of the PVA-PNIPAM hydrogel 8 are 10 cm, 10 cm and 0.2 cm respectively. The size of the PVA-PNIPAM hydrogel 8 is adapted to the size of the placement area 12 .

[0052] The length and width of the flash-steamed nonwoven fabric 1 are both 14 cm, and the width (d) of the adhesive area 11 is 2 cm.

[0053] A method for preparing a temperature-triggered burn dressing, comprising the following steps:

[0054] S1. First, 10-30 parts by weight of polyvinyl alcohol and 90-150 parts by weight of deionized water are placed in a container, and then the container, the polyvinyl alcohol and the deionized water are continuously heated and stirred at 90° C. using a heating device. After stirring until the polyvinyl alcohol in the container is completely dissolved, the container is allowed to cool to room temperature to obtain a polyvinyl alcohol solution;

[0055] S2. Subsequently, 0.06-0.12 parts by weight of N,N-methylenebisacrylamide, 0.3-0.5 parts by weight of ammonium persulfate, and 18-27 parts by weight of N-isopropylacrylamide are sequentially added to the cooled polyvinyl alcohol solution, and the mixture is mixed and stirred. The polyvinyl alcohol solution is stirred until the N-isopropylacrylamide is completely dissolved to obtain a preliminary mixed solution.

[0056] S3, then nitrogen is introduced into the preliminary mixed solution, and 0.0002-0.0005 parts by weight of tetramethylethylenediamine is added to the preliminary mixed solution, and the mixture is stirred for five minutes under ventilation to obtain a final mixed solution;

[0057] S4, then injecting the final mixed solution into a sealed molding mold for encapsulation, and placing the mold at 8°C for 24 hours to finally obtain PVA-PNIPAM hydrogel 8;

[0058] S5, first apply 50-100 parts by weight of ammonium nitrate powder 6 on the surface of the first carrier 7 to obtain a starting carrier, then apply environmentally friendly wood glue on the edge of the surface, and then cover the second carrier 9 on the first carrier 7 to cover the surface to form a preliminary carrier;

[0059] S6, then apply environmentally friendly wood glue on the periphery of the preliminary carrier, and place it into the third carrier 5. After the environmentally friendly wood glue is air-dried, the first carrier 7, the second carrier 9 and the third carrier 5 form a sodium alginate carrier 3;

[0060] S7, firstly adhere the PVA-PNIPAM hydrogel 8 obtained in step S4 to the placement area 12 of the sodium alginate carrier 3 according to its own viscosity to obtain an initial dressing;

[0061] S8. The initial dressing is fixed to the fixing area 10 of the flash nonwoven fabric 1 using environmentally friendly wood glue, and then the adhesive 13 is applied to the sticky area 11 on the flash nonwoven fabric 1. The first release paper 2 is attached to the adhesive 13, and the second release paper 4 is attached to the PVA-PNIPAM hydrogel 8, respectively, to finally obtain the final dressing.

[0062] The amount of the polyvinyl alcohol is 10 parts by weight, the amount of the deionized water is 90 parts by weight, the amount of the N,N-methylenebisacrylamide is 0.0616 parts by weight, the amount of the ammonium persulfate is 0.3 parts by weight, the amount of the N-isopropylacrylamide is 18 parts by weight, the amount of the tetramethylethylenediamine is 0.0002 parts by weight, and the amount of the ammonium nitrate powder 6 is 90 parts by weight.

[0063] In the step S1, the parameter of the heating and stirring is 500-600r / min, in the step S2, the parameter of the mixing and stirring is 500-600r / min, in the step S3, the parameter of the ventilation and stirring is 500-600r / min, in the step S1, the heating and stirring time is greater than 2h, and in the step S2, the mixing and stirring time is greater than 30min.

[0064] In step S5, the starting vector is obtained according to the following steps:

[0065] Step 1: First, lay the first carrier 7 flat on the table, and then use a medicine spoon to take out a certain amount of ammonium nitrate powder 6 and sprinkle it on the surface of the first carrier 7;

[0066] Step 2: Take another clean cotton swab, and then use the cotton swab to evenly spread the ammonium nitrate powder 6 that has fallen on the above-mentioned first carrier 7 on the surface of the first carrier 7, allowing the ammonium nitrate powder 6 to adhere to the fiber fluff on the surface of the first carrier 7 to obtain a starting carrier.

[0067] In step S6, the sodium alginate carrier 3 is obtained according to the following steps:

[0068] Step 1: First, select a sodium alginate block with the dimensions of 10.2 cm in length, 10.2 cm in width, and 0.6 cm in height. Then, cut a square hole in the sodium alginate block according to the length and width of the first carrier 7 and the second carrier 9 to obtain a third carrier 5 with a hollow interior.

[0069] Step 2: First, apply environmentally friendly wood glue on the periphery of the preliminary carrier, then move the preliminary carrier into the third carrier 5 obtained in the first step, and make the bottom surface of the preliminary carrier flush with the lower end surface of the third carrier 5. After the environmentally friendly wood glue is air-dried, the preliminary carrier and the third carrier 5 can form a sodium alginate carrier 3.

[0070] In step S8, the final dressing is obtained according to the following steps:

[0071] Step 1: Apply adhesive 13 to the adhesive area 11 on the flash nonwoven fabric 1;

[0072] Step 2: Prepare a first release paper 2 of the same size as the flash-spun nonwoven fabric 1. Cut a hole of the same size in the center of the first release paper 2 according to the length and width of the sodium alginate carrier 3. Then, pass the first release paper 2 through the hole and adhere it to the adhesive 13 on the adhesive area 11, completely covering the adhesive 13.

[0073] Step 3: First prepare a second release paper 4 of the same size as the sodium alginate carrier 3, and then attach the second release paper 4 to the PVA-PNIPAM hydrogel 8 based on the second step, so that the second release paper 4 completely covers the PVA-PNIPAM hydrogel 8 and the sodium alginate carrier 3, and finally obtain the final dressing.

[0074] The supplementary technical features of the present invention are as follows:

[0075] The adhesive 13 involved in the present invention is preferably a medical adhesive. The main components of the medical adhesive are n-butyl α-cyanoacrylate, sulfur dioxide and hydroquinone. It has the characteristics of high viscosity, fast bonding speed, non-toxicity, easy tearing and non-stickiness. When combined with the flash-steamed nonwoven fabric 1, the adhesive can play the role of a medical pressure-sensitive adhesive, which can be close to the skin without affecting the skin.

[0076] The shape of the sodium alginate carrier 3 involved in the present invention is preferably a rectangular parallelepiped with a partially hollow interior near the top surface and a missing top surface. The sodium alginate carrier 3 is preferably Huaxia Junan alginate dressing. After absorbing water, the sodium alginate carrier 3 forms a layer of hydrogel, which can block the reaction and prevent the ammonium nitrate solution from contacting the skin.

[0077] The mixing and aeration stirring involved in the present invention are preferably stirred in an ice-water bath.

[0078] Example 1:

[0079] See also Figure 1-Figure 3A temperature-triggered burn dressing comprises: a first release paper 2, a second release paper 4, a flash-steamed nonwoven fabric 1, a PVA-PNIPAM hydrogel 8, ammonium nitrate powder 6, a sodium alginate carrier 3, a first carrier 7, a second carrier 9 and a third carrier 5; a fixing area 10 is formed at a central portion of the top surface of the flash-steamed nonwoven fabric 1, and adhesive areas 11 are formed at other portions of the top surface of the flash-steamed nonwoven fabric 1; the bottom surface of the sodium alginate carrier 3 is fixed at the fixing area 10; the sodium alginate carrier 3 comprises a first carrier 7, a second carrier 9 and a third carrier 5; the bottom surface of the first carrier 7 is fixed at the fixing area 10, the bottom surface of the second carrier 9 is fixed to the top surface of the first carrier 7; the ammonium nitrate powder 6 is applied to a portion between the first carrier 7 and the second carrier 9; the bottom surface of the third carrier 5 is fixed at the fixing area 10; the outer side of the first carrier 7 is fixed at At a position on the inner wall of the third carrier 5 near its lower end surface, the outer side of the second carrier 9 is fixed to a position on the inner wall of the third carrier 5 near its lower end surface, and a placement area 12 is formed on the top surface of the second carrier 9 at the inner upper side of the third carrier 5. The PVA-PNIPAM hydrogel 8 is fixed in the placement area 12, and the bottom surface of the PVA-PNIPAM hydrogel 8 is adhered to the top surface of the second carrier 9. The outer periphery of the PVA-PNIPAM hydrogel 8 is adhered to the inner wall of the third carrier 5. The PVA-PNIPAM hydrogel 8, the second carrier 9, the ammonium nitrate powder 6, the first carrier 7 and the flash-steamed non-woven fabric 1 are distributed in sequence from top to bottom. The adhesive 13 is adhered to the adhesive area 11, the bottom surface of the first release paper 2 is attached to the top surface of the adhesive 13, and the bottom surface of the second release paper 4 is attached to the top surface of the PVA-PNIPAM hydrogel 8.

[0080] During application, when burns occur on human skin, the dressing can be used for first aid treatment. During the first aid treatment, first observe whether the surface skin of the wound is damaged. If the surface skin is damaged, the wound must be cleaned before using the dressing. If the surface skin is not damaged, the dressing can be used directly. When dressing, first peel off the first release paper 2 and the second release paper 4, then cover the wound with the PVA-PNIPAM hydrogel 8, and connect the adhesive 13 on the flash-steamed nonwoven fabric 1 to the skin at the edge of the wound, and absorb heat from the wound through the PVA-PNIPAM hydrogel 8. Cooling work, and after the PVA-PNIPAM hydrogel 8 absorbs heat, the PVA-PNIPAM hydrogel 8 will shrink and release water. The released water will dissolve the ammonium nitrate powder 6 between the first carrier 7 and the second carrier 9 through absorption and conduction by the second carrier 9. The ammonium nitrate powder 6 absorbs heat after contacting with water, and further absorbs heat and cools the wound. Under the heat absorption and cooling of the PVA-PNIPAM hydrogel 8 and the ammonium nitrate powder 6, the wound can be effectively cooled, so that more heat from the wound can be transferred to the dressing with a lower temperature, so as to avoid more damage to the protective deep tissue of the wound.

[0081] The principle of heat absorption and cooling of ammonium nitrate powder 6 and water is as follows:

[0082] When ammonium nitrate crystals come into contact with water, they dissociate into the ions NH4 + With NO3 - Dissociation requires energy because it destroys the strong electrostatic attraction between ions, which will cause the ammonium nitrate crystals to absorb heat from the surrounding environment during the dissociation process. Therefore, the ammonium nitrate powder 6 will absorb heat and cool down after contacting water.

[0083] The principle of PVA-PNIPAM hydrogel 8 absorbing heat and releasing water is as follows:

[0084] PVA-PNIPAM hydrogel 8 contains two parts, amide and isopropyl, and has a critical solution temperature of 34 °C in aqueous medium; Figure 4As shown in the figure, when PVA-PNIPAM hydrogel 8 is near the critical solution temperature, PVA-PNIPAM hydrogel 8 will exhibit a drastic and reversible volume phase change by expanding or contracting, accompanied by changes in hydrophilicity and transparency. When the contact temperature of PVA-PNIPAM hydrogel 8 is lower than the critical solution temperature of PNIPAM hydrogel, the hydrogen bonds between the hydrophilic amide groups and water molecules offset the hydrophobic interactions between the isopropyl groups, and a highly organized water molecule layer will be formed around the amide groups; when the contact temperature of PVA-PNIPAM hydrogel 8 is higher than its critical solution temperature, the hydrogen bonds in PVA-PNIPAM hydrogel 8 are weakened, and the hydrophobic interactions between the isopropyl groups become stronger. The PNIPAM chains therein are dehydrated and aggregated into a tightly packed spherical conformation. Therefore, PVA-PNIPAM hydrogel 8 absorbs heat and releases water.

[0085] This temperature-triggered burn dressing can be stored at room temperature and used as it comes into contact with a wound. Its component, PVA-PNIPAM hydrogel 8, releases water only when it comes into contact with an object with a temperature higher than its critical dissolution temperature. It absorbs heat by reacting with ammonium nitrate powder 6. Therefore, this temperature-triggered burn dressing can be stored at room temperature and used as it comes into contact with the wound. It can immediately react and cool the wound, rapidly cooling it.

[0086] This temperature-triggered burn dressing is intended for first aid treatment. It does not require prolonged use to cover the wound, and can also reduce tissue fluid produced when the surface skin is damaged during cold compresses. PVA-PNIPAM hydrogel 8 has excellent biocompatibility and will not adversely affect the wound. The water it releases does not contain other chemicals and will not irritate or damage the wound, making it highly safe.

[0087] Example 2:

[0088] The basic content is the same as Example 1, except that:

[0089] See also Figure 2-Figure 3 In this embodiment, the length, width and height of the first carrier 7 are 10 cm, 10 cm and 0.2 cm respectively. The length, width and height of the first carrier 7 are 10 cm, 10 cm and 0.2 cm respectively. The first carrier 7 and the second carrier 9 have the same size. The length, width and height of the placement area 12 are 10 cm, 10 cm and 0.2 cm respectively; the length, width and height of the PVA-PNIPAM hydrogel 8 are 10 cm, 10 cm and 0.2 cm respectively. The size of the PVA-PNIPAM hydrogel 8 is adapted to the size of the placement area 12; the length and width of the flash-steamed nonwoven fabric 1 are both 14 cm, and the width (d) of the adhesive area 11 is 2 cm.

[0090] During application, the size of a single piece of PVA-PNIPAM hydrogel 8 can adapt to a small area of ​​wound and cover the wound. At the same time, during the process of absorbing heat and cooling a large area of ​​wound, the adhesive areas 11 of the flash-steamed non-woven fabrics 1 on multiple dressings can be overlapped up and down, and the two flash-steamed non-woven fabrics 1 can be connected by an adhesive 13 to combine multiple dressings together. After the multiple dressings are combined, they can adapt to a large area of ​​wound. When multiple dressings are assembled, two adjacent PVA-PNIPAM hydrogels 8 will abut against each other, allowing the PVA-PNIPAM hydrogel 8 to cover all wounds.

[0091] Example 3:

[0092] The basic content is the same as Example 1, except that:

[0093] See also Figure 6-Figure 7A method for preparing a temperature-triggered burn dressing, comprising the following steps: S1, first placing 10-30 parts by weight of polyvinyl alcohol and 90-150 parts by weight of deionized water in a container, then continuously heating and stirring the container, the polyvinyl alcohol, and the deionized water at 90°C using a heating device, stirring until the polyvinyl alcohol in the container is completely dissolved, and then cooling the container to room temperature to obtain a polyvinyl alcohol solution; S2, then adding 0.06-0.12 parts by weight of N,N-methylenebisacrylamide, 0.3-0.5 parts by weight of Parts of ammonium persulfate and 18-27 parts by weight of N-isopropylacrylamide are sequentially added to the cooled polyvinyl alcohol solution and mixed and stirred. After the polyvinyl alcohol solution is stirred until the N-isopropylacrylamide is completely dissolved, a preliminary mixed solution is obtained; S3, nitrogen is then introduced into the preliminary mixed solution, and 0.0002-0.0005 parts by weight of tetramethylethylenediamine is added to the preliminary mixed solution, and the mixture is stirred for five minutes to obtain a final mixed solution; S4, the final mixed solution is then injected into a sealing mold for packaging, and the final mixed solution is sealed. The mold is placed in an environment of 8°C for 24 hours to finally obtain PVA-PNIPAM hydrogel 8; S5, first apply 50-100 parts by weight of ammonium nitrate powder 6 on the surface of the first carrier 7 to obtain a starting carrier, then apply environmentally friendly wood glue on the edge of the surface, and then cover the second carrier 9 on the first carrier 7 to cover the surface to form a preliminary carrier; S6, then apply environmentally friendly wood glue on the periphery of the preliminary carrier and place it in the third carrier 5. After the environmentally friendly wood glue is air-dried, the first carrier 7, the second carrier 9 and the third carrier 5 are placed together. Three carriers 5 form a sodium alginate carrier 3; S7, first, the PVA-PNIPAM hydrogel 8 obtained according to step S4 is adhered to the placement area 12 of the sodium alginate carrier 3 according to its own viscosity to obtain an initial dressing; S8, the initial dressing is then fixed to the fixing area 10 of the flash-steamed non-woven fabric 1 using environmentally friendly wood glue, and then adhesive is applied to the adhesive area 11 on the flash-steamed non-woven fabric 1, and the first release paper 2 is attached to the adhesive and the second release paper 4 is attached to the PVA-PNIPAM hydrogel 8 respectively, to finally obtain a final dressing.

[0094] During application, when the dressing comes into contact with the wound, the PVA-PNIPAM hydrogel 8 will release 15 ml of water. More than 80% of the water in the PVA-PNIPAM hydrogel 8 can be released within 1 minute, and the remaining water will be completely released after 3-5 minutes. After the ammonium nitrate powder 6 dissolves in water, the temperature of the wound can be maintained at 10-15°C, and the maintenance time is 30-60 minutes. During the use of the dressing, small and medium-sized mild burns should be cold compressed for 30-60 minutes, and the dressing should be changed every 30 minutes if the wound is painless or slightly painful; small and medium-sized moderate burns should be cold compressed and the dressing should be changed after 20 minutes until there is no obvious burning pain in the wound; for larger areas or more serious burns, the dressing should be cold compressed and the dressing should be changed every 20 minutes.

[0095] Example 4:

[0096] The basic content is the same as Example 3, except that:

[0097] See also Figure 6 In this embodiment, the amount of polyvinyl alcohol used is 10 parts by weight, the amount of deionized water used is 90 parts by weight, the amount of N,N-methylenebisacrylamide used is 0.0616 parts by weight, the amount of ammonium persulfate used is 0.3 parts by weight, the amount of N-isopropylacrylamide used is 18 parts by weight, the amount of tetramethylethylenediamine used is 0.0002 parts by weight, and the amount of ammonium nitrate powder 6 used is 90 parts by weight.

[0098] The above materials are prepared according to the corresponding weight parts to obtain two PVA-PNIPAM hydrogels 8 with a water release capacity of 15 ml. The reaction of 15 ml of water with 90 parts by weight of ammonium nitrate powder 6 can maintain the temperature of the wound at 10-15°C within 30-60 minutes. At the same time, 90 parts by weight of ammonium nitrate powder 6 can meet the requirements of the first carrier 7 and the second carrier 9 with a length and width of 10 cm.

[0099] Example 5:

[0100] The basic content is the same as Example 3, except that:

[0101] See also Figure 6 In this embodiment, the heating and stirring parameters in step S1 are 500-600r / min, the mixing and stirring parameters in step S2 are 500-600r / min, the aeration and stirring parameters in step S3 are 500-600r / min, the heating and stirring time in step S1 is greater than 2h, and the mixing and stirring time in step S2 is greater than 30min.

[0102] Example 6:

[0103] The basic content is the same as Example 3, except that:

[0104] See also Figure 6 In step S5 of this embodiment, the starting carrier is obtained according to the following steps: Step 1: first, lay the first carrier 7 flat on the table, and then use a medicine spoon to take out a certain amount of ammonium nitrate powder 6 and sprinkle it on the surface of the first carrier 7; Step 2: take a clean cotton swab, and then use the cotton swab to evenly spread the ammonium nitrate powder 6 on the first carrier 7 to the surface of the first carrier 7, so that the ammonium nitrate powder 6 adheres to the fiber fluff on the surface of the first carrier 7, as shown in FIG. Figure 5 As shown, the starting vector was obtained.

[0105] Example 7:

[0106] The basic content is the same as Example 3, except that:

[0107] See also Figure 6 In step S6 of this embodiment, the sodium alginate carrier 3 is obtained according to the following steps: Step 1: First, a sodium alginate block with dimensions of 10.2 cm in length, 10.2 cm in width, and 0.6 cm in height is selected, and then square holes are cut out of the sodium alginate block according to the length and width of the first carrier 7 and the second carrier 9 to obtain a third carrier 5 with a hollow interior; Step 2: First, environmentally friendly wood glue is applied to the outer periphery of the preliminary carrier, and then the preliminary carrier is moved into the third carrier 5 obtained in the first step, and the bottom surface of the preliminary carrier is flush with the lower end surface of the third carrier 5. After the environmentally friendly wood glue is air-dried, the preliminary carrier and the third carrier 5 can form the sodium alginate carrier 3.

[0108] Example 8:

[0109] The basic content is the same as Example 3, except that:

[0110] See also Figure 6 In step S8 of this embodiment, the final dressing is obtained according to the following steps: Step 1: Applying adhesive 13 to the adhesive area 11 of the flash-steamed non-woven fabric 1; Step 2: First, prepare a first release paper 2 of the same size as the flash-steamed non-woven fabric 1, and then cut a corresponding size of perforation at the center of the first release paper 2 according to the length and width of the sodium alginate carrier 3, and then allow the first release paper 2 to pass through the sodium alginate carrier 3 through the perforation and adhere to the adhesive 13 on the adhesive area 11, completely covering the adhesive 13; Step 3: First, prepare a second release paper 4 of the same size as the sodium alginate carrier 3, and then adhere the second release paper 4 to the PVA-PNIPAM hydrogel 8 based on the second step, so that the second release paper 4 completely covers the PVA-PNIPAM hydrogel 8 and the sodium alginate carrier 3, and finally obtain the final dressing.

[0111] The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiment. Any equivalent modifications or changes made by ordinary technicians in this field based on the contents disclosed in the present invention should be included in the protection scope recorded in the claims.

Claims

1. A temperature-triggered burn dressing, characterized by: The temperature-triggered burn dressing comprises: a first release paper (2), a second release paper (4), a flash-steamed nonwoven fabric (1), a PVA-PNIPAM hydrogel (8), ammonium nitrate powder (6), a sodium alginate carrier (3), a first carrier (7), a second carrier (9) and a third carrier (5); A fixing area (10) is formed at a central portion of the top surface of the flash-steamed nonwoven fabric (1), and an adhesive area (11) is formed at other portions of the top surface of the flash-steamed nonwoven fabric (1). The bottom surface of the sodium alginate carrier (3) is fixed at the fixing area (10). The sodium alginate carrier (3) comprises a first carrier (7), a second carrier (9), and a third carrier (5). The bottom surface of the first carrier (7) is fixed at the fixing area (10), and the bottom surface of the second carrier (9) is fixed to the top surface of the first carrier (7). The ammonium nitrate powder (6) is applied to a portion between the first carrier (7) and the second carrier (9). The bottom surface of the third carrier (5) is fixed at the fixing area (10). The outer side of the first carrier (7) is fixed to a portion of the inner wall of the third carrier (5) close to its lower end surface, and the outer side of the second carrier (9) is fixed to the inner wall of the third carrier (5). At a position near the lower end surface thereof, a placement area (12) is formed on the top surface of the second carrier (9) and is located on the inner upper side of the third carrier (5). The PVA-PNIPAM hydrogel (8) is fixed in the placement area (12). The bottom surface of the PVA-PNIPAM hydrogel (8) is adhered to the top surface of the second carrier (9). The periphery of the PVA-PNIPAM hydrogel (8) is adhered to the inner wall of the third carrier (5). The PVA-PNIPAM hydrogel (8), the second carrier (9), the ammonium nitrate powder (6), the first carrier (7) and the flash-steamed non-woven fabric (1) are distributed in sequence from top to bottom. The adhesive (13) is adhered to the adhesive area (11). The bottom surface of the first release paper (2) is attached to the top surface of the adhesive (13), and the bottom surface of the second release paper (4) is attached to the top surface of the PVA-PNIPAM hydrogel (8).

2. The temperature-triggered burn dressing according to claim 1, characterized in that: The length, width and height of the first carrier (7) are 10 cm, 10 cm and 0.2 cm respectively. The length, width and height of the first carrier (7) are 10 cm, 10 cm and 0.2 cm respectively. The first carrier (7) and the second carrier (9) have the same size. The length, width and height of the placement area (12) are 10 cm, 10 cm and 0.2 cm respectively.

3. The temperature-triggered burn dressing according to claim 2, characterized in that: The length, width and height of the PVA-PNIPAM hydrogel (8) are 10 cm, 10 cm and 0.2 cm respectively. The size of the PVA-PNIPAM hydrogel (8) is compatible with the size of the placement area (12).

4. The temperature-triggered burn dressing according to claim 1, characterized in that: The length and width of the flash-steamed nonwoven fabric (1) are both 14 cm, and the width (d) of the adhesive area (11) is 2 cm.

5. A method for preparing the temperature-triggered burn dressing according to claim 1, characterized in that: The preparation method comprises the following steps: S1. First, 10-30 parts by weight of polyvinyl alcohol and 90-150 parts by weight of deionized water are placed in a container, and then the container, the polyvinyl alcohol and the deionized water are continuously heated and stirred at 90° C. using a heating device. After stirring until the polyvinyl alcohol in the container is completely dissolved, the container is allowed to cool to room temperature to obtain a polyvinyl alcohol solution; S2. Subsequently, 0.06-0.12 parts by weight of N,N-methylenebisacrylamide, 0.3-0.5 parts by weight of ammonium persulfate, and 18-27 parts by weight of N-isopropylacrylamide are sequentially added to the cooled polyvinyl alcohol solution, and the mixture is mixed and stirred. The polyvinyl alcohol solution is stirred until the N-isopropylacrylamide is completely dissolved to obtain a preliminary mixed solution. S3, then nitrogen is introduced into the preliminary mixed solution, and 0.0002-0.0005 parts by weight of tetramethylethylenediamine is added to the preliminary mixed solution, and the mixture is stirred for five minutes under ventilation to obtain a final mixed solution; S4, then injecting the final mixed solution into a sealed molding mold for encapsulation, and placing the mold at 8°C for 24 hours to finally obtain PVA-PNIPAM hydrogel (8); S5, first applying 50-100 parts by weight of ammonium nitrate powder (6) on the surface of the first carrier (7) to obtain a starting carrier, then applying environmentally friendly wood glue on the edge of the surface, and then covering the second carrier (9) on the first carrier (7) to cover the surface to form a preliminary carrier; S6, then apply environmentally friendly wood glue on the periphery of the preliminary carrier and place it into the third carrier (5). After the environmentally friendly wood glue is air-dried, the first carrier (7), the second carrier (9) and the third carrier (5) form a sodium alginate carrier (3); S7, firstly adhere the PVA-PNIPAM hydrogel (8) obtained according to step S4 to the placement area (12) of the sodium alginate carrier (3) based on its own viscosity to obtain an initial dressing; S8. The initial dressing is then fixed to the fixing area (10) of the flash nonwoven fabric (1) using environmentally friendly wood glue, and then the adhesive (13) is applied to the sticky area (11) on the flash nonwoven fabric (1), and the first release paper (2) is attached to the adhesive (13) and the second release paper (4) is attached to the PVA-PNIPAM hydrogel (8), and finally the final dressing is obtained.

6. The method for preparing a temperature-triggered burn dressing according to claim 5, characterized in that: The amount of polyvinyl alcohol used is 10 parts by weight, the amount of deionized water used is 90 parts by weight, the amount of N,N-methylenebisacrylamide used is 0.0616 parts by weight, the amount of ammonium persulfate used is 0.3 parts by weight, the amount of N-isopropylacrylamide used is 18 parts by weight, the amount of tetramethylethylenediamine used is 0.0002 parts by weight, and the amount of ammonium nitrate powder (6) used is 90 parts by weight.

7. The method for preparing a temperature-triggered burn dressing according to claim 5, characterized in that: In the step S1, the parameter of the heating and stirring is 500-600r / min, in the step S2, the parameter of the mixing and stirring is 500-600r / min, in the step S3, the parameter of the ventilation and stirring is 500-600r / min, in the step S1, the heating and stirring time is greater than 2h, and in the step S2, the mixing and stirring time is greater than 30min.

8. The method for preparing a temperature-triggered burn dressing according to claim 5, characterized in that: In step S5, the starting vector is obtained according to the following steps: Step 1: first, spread the first carrier (7) flat on the table, and then use a medicine spoon to take out a certain amount of ammonium nitrate powder (6) and sprinkle it on the surface of the first carrier (7); Step 2: Take another clean cotton swab and use it to evenly spread the ammonium nitrate powder (6) that has fallen on the first carrier (7) onto the surface of the first carrier (7), allowing the ammonium nitrate powder (6) to adhere to the fiber fluff on the surface of the first carrier (7) to obtain a starting carrier.

9. The method for preparing a temperature-triggered burn dressing according to claim 5, characterized in that: In step S6, the sodium alginate carrier (3) is obtained according to the following steps: Step 1: First, a sodium alginate block with the dimensions of 10.2 cm in length, 10.2 cm in width, and 0.6 cm in height is selected, and then a square hole is cut out of the sodium alginate block according to the length and width of the first carrier (7) and the second carrier (9) to obtain a third carrier (5) with a hollow interior; Step 2: First, apply environmentally friendly wood glue on the periphery of the preliminary carrier, then move the preliminary carrier into the third carrier (5) obtained in the first step, and make the bottom surface of the preliminary carrier flush with the lower end surface of the third carrier (5). After the environmentally friendly wood glue is air-dried, the preliminary carrier and the third carrier (5) can form a sodium alginate carrier (3).

10. The method for preparing a temperature-triggered burn dressing according to claim 5, characterized in that: In step S8, the final dressing is obtained according to the following steps: Step 1: applying adhesive (13) to the adhesive area (11) on the flash nonwoven fabric (1); Step 2: First, prepare a first release paper (2) of the same size as the flash nonwoven fabric (1), and then cut a corresponding size of perforation at the center of the first release paper (2) according to the length and width of the sodium alginate carrier (3), and then let the first release paper (2) pass through the sodium alginate carrier (3) through the perforation and adhere to the adhesive (13) on the adhesive area (11), completely covering the adhesive (13); Step 3: First prepare a second release paper (4) of the same size as the sodium alginate carrier (3), and then attach the second release paper (4) to the PVA-PNIPAM hydrogel (8) based on the second step, so that the second release paper (4) completely covers the PVA-PNIPAM hydrogel (8) and the sodium alginate carrier (3), and finally obtain the final dressing.

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