Plant antibacterial and anti-inflammatory composition, cream as well as preparation method and application of plant antibacterial and anti-inflammatory composition and cream

Abstract

The invention provides a plant antibacterial and anti-inflammatory composition, cream and a preparation method and application of the plant antibacterial and anti-inflammatory composition and cream, and belongs to the technical field of cosmetics, the plant antibacterial and anti-inflammatory composition is prepared from the following components in parts by weight: 4-12 parts of a good mousse fruit seed extract, 15-25 parts of good mousse fruit leaf hydrolat, 11-33 parts of emblic leafflower fruit hydrolat and 4-8 parts of finger lemon essential oil. The plant antisepsis and anti-inflammation composition has multiple functions of antisepsis, anti-inflammation, oil control, cytokeratinization inhibition and the like, can significantly improve skin conditions of acne patients, and avoids irritation and side effects caused by chemical drugs. The invention further provides cream containing the plant antibacterial and anti-inflammatory composition and a preparation method of the cream, the cream is extremely remarkable in oil control effect and has good sterilization and anti-inflammatory effects, and the acne symptom is obviously relieved.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics, and in particular relates to a plant antibacterial and anti-inflammatory composition, a cream, and a preparation method and application thereof. Background Art

[0002] Acne is commonly known as pimples and dark pimples. In ancient Chinese medicine, it was called facial sores and wine pimples. It is a common skin problem. Excessive secretion of sebum is the pathological basis for the occurrence of acne. Abnormal keratinization of cells around hair follicles is another important factor in the occurrence of acne. Abnormal keratinization of cells around hair follicles causes the hair follicle opening to become smaller, narrower, and blocked, which prevents the discharge of sebum, forming visible acne or invisible micro-acne. Propionibacterium acnes can stimulate inflammatory reactions in and around hair follicles, causing local papules, pustules, nodules, and abscesses. Inflammatory reactions, because sebum overflow leads to increased reproduction of Propionibacterium acnes, Propionibacterium acnes aggravates inflammation of varying degrees by regulating the expression of Toll-like receptors, resulting in a series of clinical symptoms ranging from inflammatory papules to cysts. Acne puts a burden on patients' appearance and psychology.

[0003] Traditionally, the treatment of acne mainly relies on topical treatment drugs, such as salicylic acid, benzoyl peroxide, etc. These drugs may cause dryness or irritation of the skin, bring great side effects, and limit the feasibility of long-term use and patient acceptance. Therefore, developing a cosmetic with natural medicinal plants as the main raw material can not only reduce the irritation of chemical drugs to the skin, reduce the allergic reaction of the skin, but also effectively control the formation and development of acne, eliminate acne marks, keep the skin healthy and comfortable, and make patients psychologically accept it. Summary of the invention

[0004] In view of this, the object of the present invention is to provide a plant antibacterial and anti-inflammatory composition, a preparation method thereof, and an application in the preparation of skin care products. The plant antibacterial and anti-inflammatory composition has multiple functions such as antibacterial, anti-inflammatory, oil control, and inhibition of cell keratinization, and can significantly improve the skin condition of acne patients and avoid the irritation and side effects caused by chemical drugs.

[0005] The invention provides a plant antibacterial and anti-inflammatory composition, comprising the following components in parts by weight: 4-12 parts of jamu fruit seed extract, 15-25 parts of jamu fruit leaf pure water, 11-33 parts of emblica fruit pure water, and 4-8 parts of lemon essential oil.

[0006] Preferably, the jamu seed extract is an ethanol extract of jamu seeds.

[0007] The present invention provides application of the plant antibacterial and anti-inflammatory composition in preparing medicines or skin care products for preventing and / or treating acne.

[0008] The invention provides a cream for preventing and / or treating acne, comprising the following components in parts by weight: 4-12 parts of jasmine seed extract, 15-25 parts of jasmine leaf hydrosol, 11-33 parts of emblica oleracea hydrosol, 4-8 parts of lemongrass essential oil, 1 part of tretinoin cream, 18 parts of olive oil, 10 parts of beeswax, 7 parts of glycerin and 8 parts of lecithin.

[0009] The present invention provides a method for preparing the cream, comprising the following steps:

[0010] 1) crushing the seeds of the jamu fruit and extracting them with ethanol to obtain the jamu fruit seed extract; and distilling and extracting the jamu fruit leaves to obtain the jamu fruit leaf hydrosol;

[0011] 2) mixing the emblica hydrosol, the jasmine leaf hydrosol, the jasmine seed extract and glycerin in sequence to obtain an aqueous phase;

[0012] 3) dissolving beeswax in olive oil and mixing with lecithin to obtain an oil phase;

[0013] 4) The aqueous phase obtained in step 2) is mixed with the oil phase obtained in step 3), and then mixed with retinoic acid cream and finger lemon essential oil to obtain a cream.

[0014] Preferably, the jamu seeds in step 1) are dried and then crushed.

[0015] Preferably, the temperature of the ethanol extraction is 50-55° C., the time of the ethanol extraction is 80-100 minutes, the mass ratio of jamu seeds to ethanol is 1:(10-20), and the volume concentration of the ethanol is 60-80%.

[0016] Preferably, the dissolution temperature is 50-55° C., and the dissolution time is 30-100 minutes.

[0017] Preferably, in step 4), the water phase and the oil phase are mixed by dividing the water phase into 3 to 5 portions and mixing them with the oil phase in batches.

[0018] The present invention also provides application of the cream in preparing a medicine for preventing and / or treating acne.

[0019] Compared with the prior art, the present invention has the following beneficial effects: the present invention provides a plant antibacterial and anti-inflammatory composition, including jamu fruit seed extract, jamu fruit leaf hydrosol, emblica fruit hydrosol and finger lemon essential oil, which can target the mechanism of acne occurrence, efficiently control skin oil secretion, inhibit bacteria and reduce inflammation, and effectively improve acne symptoms. The present invention uses natural plant raw materials, has less irritation to the patient's skin, has no obvious allergic reaction to the skin, and is more easily accepted by patients.

[0020] The cream for preventing and / or treating acne provided by the present invention comprises the above-mentioned plant antibacterial and anti-inflammatory composition, and has multiple functions such as antibacterial, anti-inflammatory, oil control and inhibition of cell keratinization, and can significantly improve the skin treatment effect of acne patients and avoid the irritation and side effects caused by chemical drugs. DETAILED DESCRIPTION

[0021] The invention provides a plant antibacterial and anti-inflammatory composition, comprising the following components in parts by weight: 4-12 parts of jamu fruit seed extract, 15-25 parts of jamu fruit leaf pure water, 11-33 parts of emblica fruit pure water, and 4-8 parts of lemon essential oil.

[0022] In the present invention, the plant antibacterial and anti-inflammatory composition comprises 4 to 12 parts of jasmine seed extract, preferably 8 to 12 parts.

[0023] Jamun is a purple-black fruit that mainly grows in South Asia. It is a very famous medicinal plant in the world and an important cornerstone of Indian Ayurvedic medicine. It has multiple benefits for the skin because it is rich in antioxidants (such as vitamin C and polyphenolic compounds). Jamun can effectively reduce skin oiliness, has excellent oil removal effect, and prevents pores from clogging. It also contains alkaloids, flavonoids and other ingredients that eliminate free radicals and increase cell activity. Jamun seeds are rich in various terpenes and phenolic compounds, which promote strong skin regeneration ability, have strong astringency, prevent skin wrinkles, and maintain elasticity. Jamun has strong bactericidal and anti-inflammatory ability. In addition, it can effectively moisturize the skin and enhance the skin barrier function.

[0024] In the present invention, the kamu fruit seed extract is preferably an ethanol extract of kamu fruit seeds. The kamu fruit seeds are preferably fresh kamu fruit seeds with the pulp removed. The present invention preferably washes the seeds and then naturally dries them. After they are completely dried, they are ground into powder, and the particle size of the powder is preferably 50 to 100 meshes. Then, kamu fruit powder is extracted with ethanol.

[0025] In the present invention, the plant antibacterial and anti-inflammatory composition comprises 15 to 25 parts of jamu leaf hydrosol, preferably 20 to 25 parts. In the present invention, the jamu leaf hydrosol preferably uses fresh jamu leaf, and the jamu leaf hydrosol is extracted by distillation.

[0026] The chemicals in jamu leaves contain astringent properties that help neutralize excess natural oils on the skin. The leaves of jamu are rich in nutrients and antioxidants. They are an excellent remedy for scars, dark spots, blemishes, etc. The vitamin C and antioxidants in jamu help to remove dead cells and toxins from the skin that can cause dark spots and other pigmentation problems. They are also very good at promoting the development of new skin cells. The jamu hydrosol has antibacterial and anti-inflammatory effects and inhibits oil production.

[0027] In the present invention, the plant antibacterial and anti-inflammatory composition comprises 11 to 33 parts of emblica hydrosol, preferably 12 to 23 parts. In the present invention, fresh emblica slices are preferably used, and the slice thickness is preferably 0.3 to 0.8 mm, and the emblica hydrosol is extracted by distillation.

[0028] Phyllanthus emblica L, native to India, is an important medicinal plant in Indian Ayurvedic medicine. It is a berry rich in vitamin C and a large amount of ellagitannins, polyphenol compounds and antioxidants, which has multiple benefits for the skin. It can effectively neutralize free radicals, delay skin aging, promote collagen synthesis, and maintain skin elasticity and health. Phyllanthus emblica also has a strong bactericidal and anti-inflammatory effect, which helps to reduce skin inflammation and promote wound healing. Phyllanthus emblica hydrosol has the effect of sterilization, anti-inflammatory and inhibiting acne.

[0029] In the present invention, the plant antibacterial and anti-inflammatory composition comprises 4 to 8 parts of finger lemon essential oil, preferably 8 parts. In the present invention, the finger lemon essential oil is preferably obtained by steam distillation extraction using fresh finger lemon slices, preferably with a thickness of 0.3 to 0.8 mm.

[0030] Finger lime, native to Australia, is very high in vitamin C. 100g of vitamin C contains up to 557mg, which is ten times the content of ordinary citrus. It has strong antioxidant properties and can fight against oil accumulation and wrinkles while improving skin moisture. Finger lime can also inhibit keratin formation and promote the production of good collagen. It is rich in flavonoids and is a powerful antioxidant that can help protect the skin from free radical damage and reduce inflammation. Finger lemon fruit extract is a source of magnesium ascorbyl phosphate, which has been shown to brighten the skin. The citric acid contained in finger lemon can not only prevent and eliminate the deposition of pigments in the skin, but also soften the skin's stratum corneum, making the skin white and elastic. Finger lemon is rich in limonene, which can inhibit oil secretion.

[0031] The present invention also provides the use of the plant antibacterial and anti-inflammatory composition in the preparation of a medicine or skin care product for preventing and / or treating acne. The present invention does not specifically limit the specific dosage form of the medicine or skin care product, and any conventional dosage form in the art can be used.

[0032] The present invention also provides a cream for preventing and / or treating acne, comprising the following components in parts by weight: 4-12 parts of jasmine seed extract, 15-25 parts of jasmine leaf hydrosol, 11-33 parts of emblica hydrosol, 4-8 parts of lemongrass essential oil, 0.5-1.5 parts of retinoic acid cream, 18 parts of olive oil, 10 parts of beeswax, 7 parts of glycerin and 8 parts of lecithin.

[0033] In the present invention, the cream includes 4 to 12 parts of camu camu seed extract, preferably 8 to 12 parts; includes 15 to 25 parts of camu camu leaf hydrosol, preferably 20 to 25 parts; includes 11 to 33 parts of emblica hydrosol, preferably 11 to 19 parts; includes 4 to 8 parts of lemon essential oil, preferably 8 parts.

[0034] In the present invention, the cream also includes 1 portion of tretinoin cream; in the present invention, the tretinoin cream is rich in vitamin A, which helps to promote the metabolism and repair of skin cells and accelerate the wound healing process.

[0035] In the present invention, the cream further comprises 18 parts of olive oil; in the present invention, the olive oil can provide rich nutrition and moisturizing, help to restore the natural barrier function of the skin, and maintain the hydration state of the skin.

[0036] In the present invention, the cream further comprises 10 parts of beeswax. In the present invention, the beeswax is used as an auxiliary emulsifier.

[0037] In the present invention, the cream further comprises 7 parts of glycerin. In the present invention, the glycerin is used as a moisturizer and a stabilizer.

[0038] In the present invention, the cream further comprises 8 parts of lecithin. In the present invention, the lecithin has the function of moisturizing the skin.

[0039] The present invention also provides a preparation method of the cream, comprising the following steps: 1) crushing camu camu seeds and extracting with ethanol to obtain camu camu seed extract; distilling and extracting camu camu leaves to obtain camu camu leaf hydrosol; 2) mixing emblica hydrosol, camu camu leaf hydrosol, camu camu seed extract and glycerin in sequence to obtain an aqueous phase; 3) dissolving beeswax in olive oil and mixing with lecithin to obtain an oil phase; 4) mixing the aqueous phase obtained in step 2) with the oil phase obtained in step 3), and then mixing with tretinoin cream and lemon essential oil to obtain a cream.

[0040] In the present invention, the seeds of the kamu fruit are crushed and then extracted with ethanol to obtain the kamu fruit seed extract; the kamu fruit leaves are distilled and extracted to obtain the kamu fruit leaf hydrosol. In the present invention, the kamu fruit seeds are preferably dried and then crushed; it is further preferred to use the seeds of fresh kamu fruit after removing the pulp. In the present invention, the seeds are preferably washed and dried naturally, and then ground into powder after being completely dried, and then the kamu fruit powder is extracted with ethanol. In the present invention, the temperature of ethanol extraction is preferably 50-55°C, the time of ethanol extraction is preferably 90 minutes, the mass ratio of kamu fruit seeds to ethanol is preferably 1:15, and the volume concentration of ethanol is preferably 70%.

[0041] In the present invention, the kamu fruit leaf hydrosol is preferably obtained by extracting fresh kamu fruit leaves by distillation. The fresh kamu fruit leaves are first washed and then put into a distiller, and distilled water is added at a mass ratio of fresh kamu fruit leaves to distilled water of 1:2 to 4, preferably 1:3, and the water is heated to boil. After the steam is cooled, it becomes liquid to obtain the hydrosol.

[0042] In the present invention, the preparation method of the emblica hydrosol preferably comprises the following steps: fresh emblica slices are used to extract the emblica hydrosol by distillation. The emblica is first washed, then put into a distiller, distilled water is added at a mass ratio of emblica to distilled water of 1:2 to 4, preferably 1:3, and the water is heated to boil. After the steam is cooled, it becomes liquid to obtain the emblica hydrosol.

[0043] In the present invention, the emblica hydrosol, the jasmine leaf hydrosol, the jasmine seed extract, and glycerin are sequentially mixed to obtain an aqueous phase. In the present invention, the order of adding the materials is preferably the emblica hydrosol, the jasmine leaf hydrosol, the jasmine seed extract, and glycerin.

[0044] In the present invention, beeswax is dissolved in olive oil and then mixed with lecithin to obtain an oil phase. In the present invention, the dissolution temperature is preferably 50 to 70°C, more preferably 55 to 65°C; the dissolution time is preferably 30 to 100 minutes, more preferably 40 to 90 minutes. In the present invention, the olive oil is preferably heated in a water bath to the dissolution temperature, and the heating is stopped after the beeswax is completely dissolved.

[0045] After obtaining the water phase and the oil phase respectively, the water phase is mixed with the oil phase, and then mixed with tretinoin cream and finger lemon essential oil to obtain a cream. In the present invention, the water phase and the oil phase are preferably mixed by dividing the water phase into 3 to 5 parts and mixing with the oil phase in batches. In the present invention, each time the water phase is added, it is stirred until emulsified, and finally mixed with tretinoin cream and finger lemon essential oil to obtain a cream.

[0046] The present invention also provides application of the cream in preparing a medicine for preventing and / or treating acne.

[0047] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0048] Among the raw materials used in the technical solution provided by the present invention, gamu fruit and finger lemon are grown and produced on the applicant's own farm, and the others are manufactured by conventional means or purchased through commercial channels.

[0049] Example 1

[0050] To prepare 100g of cream, by weight:

[0051] Ethanol solution of jasmine seed powder extract (aqueous phase): 4g;

[0052] Jamu fruit leaf hydrosol (water phase): 15g;

[0053] Phyllanthus emblica hydrosol (water phase): 33g;

[0054] Finger lemon essential oil: 4g;

[0055] Olive oil (oil phase): 18g;

[0056] Lecithin: 8g;

[0057] Beeswax (auxiliary emulsifier, oil phase): 10g;

[0058] Additives: 1g of retinoic acid cream;

[0059] Glycerin (stabilizer): 7g.

[0060] Preparation method:

[0061] The pulp of fresh kamu fruit was removed, the seeds were taken out, washed and dried naturally, and then ground into powder after being completely dried, and then the kamu fruit powder was extracted with ethanol. The kamu fruit seeds were mixed with 70% ethanol by volume in a mass ratio of 1:15, and extracted at 55°C for 90 minutes to obtain the kamu fruit seed extract.

[0062] Extract pure water from fresh camu fruit leaves by distillation: first wash the fresh camu fruit leaves, then put them into the distiller, add 900g of distilled water to 300g of fresh camu fruit leaves, heat the water to make it boil, and after cooling, the steam will become liquid to obtain pure water.

[0063] Fresh finger lemons are sliced ​​thinly and then steam distilled to extract the essential oil.

[0064] Cut fresh emblica into thin slices and use distillation to extract the hydrosol: first wash the emblica, then put it into a distiller, add 900g of distilled water to 300g of emblica, heat the water to make it boil, and after cooling, the steam will become liquid to obtain emblica hydrosol.

[0065] Take two beakers and label them as water phase and oil phase.

[0066] In the water phase cup, first pour the amla hydrosol, then add the jasmine leaf hydrosol, then add the jasmine seed powder ethanol extract, and then add glycerin.

[0067] In the oil phase quilt, pour olive oil first and heat it in a water bath to 60°C, add beeswax to the oil phase and bathe it in water until the beeswax melts. After the beeswax melts, stop heating and add lecithin to the oil phase.

[0068] Add the water phase into the oil phase in 4 times, stirring each time, then stir for 10 minutes. Finally, add vitamin A and finger lemon essential oil and stir until emulsified.

[0069] Example 2

[0070] Take the preparation of 100g cream as an example, by weight:

[0071] Jammu fruit seed powder ethanol extract (aqueous phase): 4g;

[0072] Jamu fruit leaf hydrosol (water phase): 25g;

[0073] Phyllanthus emblica hydrosol (water phase): 23g;

[0074] Finger lemon essential oil: 4g;

[0075] Olive oil (oil phase): 18g;

[0076] Lecithin: 8g;

[0077] Beeswax (auxiliary emulsifier, oil phase): 10g;

[0078] Additives: 1g of retinoic acid cream;

[0079] Glycerin (stabilizer): 7g.

[0080] The preparation method is described in Example 1.

[0081] Embodiment 3:

[0082] Take the preparation of 100g as an example, by weight:

[0083] Jamu fruit seed powder ethanol extract (aqueous phase): 8g; Jamu fruit leaf hydrosol (aqueous phase): 25g;

[0084] Phyllanthus emblica hydrosol (water phase): 19g;

[0085] Finger lemon essential oil 4g;

[0086] Olive oil (oil phase): 18g;

[0087] Lecithin 8g;

[0088] Beeswax (auxiliary emulsifier, oil phase): 10g;

[0089] Additives: 1g of retinoic acid cream;

[0090] Glycerin (stabilizer): 7g.

[0091] The preparation method is described in Example 1.

[0092] Example 4

[0093] Take the preparation of 100g cream as an example, by weight:

[0094] Jamu fruit seed powder ethanol extract (aqueous phase): 8g; Jamu fruit leaf hydrosol (aqueous phase): 25g;

[0095] Phyllanthus emblica hydrosol (water phase): 15g;

[0096] Finger lemon essential oil 8g;

[0097] Olive oil (oil phase): 18g;

[0098] Lecithin: 8g;

[0099] Beeswax (auxiliary emulsifier, oil phase): 10g;

[0100] Additives: 1g of retinoic acid cream;

[0101] Glycerin (stabilizer): 7g.

[0102] The preparation method is described in Example 1.

[0103] Example 5

[0104] Take the preparation of 100g cream as an example, by weight:

[0105] Jamu fruit seed powder ethanol extract (aqueous phase): 10g; Jamu fruit leaf hydrosol (aqueous phase): 20;

[0106] Phyllanthus emblica hydrosol (water phase): 18g

[0107] Finger lemon essential oil: 8g;

[0108] Olive oil (oil phase): 18g;

[0109] Lecithin: 8g;

[0110] Beeswax (auxiliary emulsifier, oil phase): 10g;

[0111] Additives: 1g of retinoic acid cream;

[0112] Glycerin (stabilizer): 7g;

[0113] The preparation method is described in Example 1.

[0114] Example 6

[0115] Take the preparation of 100g cream as an example, by weight:

[0116] Jamu fruit seed powder ethanol extract (aqueous phase): 12g; Jamu fruit leaf hydrosol (aqueous phase): 20;

[0117] Phyllanthus emblica hydrosol (water phase): 16g

[0118] Finger lemon essential oil: 8g;

[0119] Olive oil (oil phase): 18g;

[0120] Lecithin: 8g;

[0121] Beeswax (auxiliary emulsifier, oil phase): 10g;

[0122] Additives: 1g of retinoic acid cream;

[0123] Glycerin (stabilizer): 7g.

[0124] The preparation method is described in Example 1.

[0125] Comparative Example 1

[0126] Take the preparation of 100g as an example, by weight:

[0127] Ethanol extract of jamu fruit seed powder (aqueous phase): 10g; Hydrosol of jamu fruit leaf (aqueous phase): 25g;

[0128] Phyllanthus emblica hydrosol (water phase): 21g;

[0129] Olive oil (oil phase): 18g;

[0130] Lecithin 8g;

[0131] Beeswax (auxiliary emulsifier, oil phase): 10g;

[0132] Additives: 1g of retinoic acid cream;

[0133] Glycerin (stabilizer): 7g.

[0134] The preparation method is described in Example 1.

[0135] Comparative Example 2

[0136] Take the preparation of 100g as an example, by weight:

[0137] Jamu fruit leaf hydrosol (water phase): 25g;

[0138] Phyllanthus emblica hydrosol (water phase): 23g;

[0139] Finger lemon essential oil 8g;

[0140] Olive oil (oil phase): 18g;

[0141] Lecithin 8g;

[0142] Beeswax (auxiliary emulsifier, oil phase): 10g;

[0143] Additives: 1g of retinoic acid cream;

[0144] Glycerin (stabilizer): 7g.

[0145] The preparation method is described in Example 1.

[0146] Experimental example

[0147] This product is developed with natural plants as the base material. Volunteers aged 18-30 were selected to participate in the test. The inclusion criteria for volunteers were patients diagnosed with acne level 1 to 4. The specific grading standards are as follows:

[0148] Grade 1 (mild): only acne;

[0149] Grade 2 (moderate): In addition to acne, there are also inflammatory papules;

[0150] Grade 3 (moderate): In addition to comedones and inflammatory papules, there are also pustules;

[0151] Grade 4 (severe): In addition to comedones, inflammatory papules and pustules, there are also nodules, cysts or scars.

[0152] The creams prepared in Examples 1 to 6 were used for testing. No other products with similar effects were used within 3 days before the test.

[0153] How to use the test product: After normal cleansing, apply an appropriate amount on the facial skin, twice a day, morning and evening, once in the morning after washing the face, once at night after showering, use for 20 consecutive days, and observe the effect at 9-10 pm.

[0154] The effect of the cream on oil secretion was tested using a skin tester. The results are shown in Table 1.

[0155] Table 1 Effect of the creams prepared in Examples 1 to 6 on the oil secretion

[0156]

[0157]

[0158] It can be seen that oil control is effective, facial oil secretion is effectively controlled, the oily shine on the face is significantly reduced, the oil secretion is significantly reduced, and the face is dry.

[0159] Combining the observations and patients' feelings, the improvement of facial inflammation is shown in Table 2. The degree of facial inflammation was reduced, the color of facial acne became darker, the acne became softer, and the abscess was reduced.

[0160] Ineffective: No significant change.

[0161] Slight improvement: Redness and swelling are relieved, itching is reduced, and the color of closed comedones becomes lighter.

[0162] Significant improvement: acne subsided, skin became smooth and bright, and abscesses disappeared.

[0163] Table 2 Effect of the creams prepared in Comparative Examples 1-2 and Examples 1-6 on facial inflammation

[0164]

[0165]

[0166] Table 3 Improvement of facial acne coverage by the creams prepared in Comparative Examples 1 to 2 and Examples 1 to 6

[0167]

[0168]

[0169] Combining human eye observation and patient experience, the skin irritation is shown in Table 4. There is little skin irritation and no obvious allergic reaction.

[0170] Table 4 Sensitization of the creams prepared in Comparative Examples 1 to 2 and Examples 1 to 6

[0171] Group Number of cases Number of allergy cases No allergy cases Allergy rate Comparative Example 1 0 0 5 0％ Comparative Example 2 0 0 5 0％ Example 1 5 0 5 0％ Example 2 5 0 5 0％ Example 3 5 0 5 0％ Example 4 5 0 5 0％ Example 5 5 0 5 0％ Example 6 5 0 5 0％

[0172] Through the effect test for 20 consecutive days, it can be clearly understood that each embodiment has obvious effects. The ethanol extract of jamu fruit seed powder is the key component for oil control; finger lemon essential oil contains a large amount of limonene, which can effectively kill bacteria and reduce inflammation. In summary, the best effects are Examples 5 and 6, especially Example 5. The cream provided by the present invention not only controls oil and significantly improves acne symptoms, but also because it is a natural plant raw material, it has no irritation to the skin and no allergic reaction, and is more easily accepted by patients.

[0173] In summary, the cream of the present invention has a very significant oil control effect, has a good bactericidal and anti-inflammatory effect, and significantly alleviates acne symptoms.

[0174] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A plant antibacterial and anti-inflammatory composition, characterized in that: The invention comprises the following components in parts by weight: 4-12 parts of jamu fruit seed extract, 15-25 parts of jamu fruit leaf pure water, 11-33 parts of emblica fruit pure water and 4-8 parts of lemongrass essential oil.

2. The plant antibacterial and anti-inflammatory composition according to claim 1, characterized in that: The jamu fruit seed extract is an ethanol extract of jamu fruit seeds.

3. Use of the plant antibacterial and anti-inflammatory composition according to claim 1 or 2 in the preparation of medicines or skin care products for preventing and / or treating acne.

4. A cream for preventing and / or treating acne, characterized in that: The invention comprises the following components in parts by weight: 4-12 parts of jamu seed extract, 15-25 parts of jamu leaf pure water, 11-33 parts of emblica fruit pure water, 4-8 parts of lemongrass essential oil, 0.5-1.5 parts of retinoic acid cream, 18 parts of olive oil, 10 parts of beeswax, 7 parts of glycerin and 8 parts of lecithin.

5. The method for preparing the cream according to claim 4, characterized in that: The following steps are involved: 1) crushing the seeds of the jamu fruit and extracting them with ethanol to obtain the jamu fruit seed extract; and distilling and extracting the jamu fruit leaves to obtain the jamu fruit leaf hydrosol; 2) mixing the emblica hydrosol, the jasmine leaf hydrosol, the jasmine seed extract and glycerin in sequence to obtain an aqueous phase; 3) dissolving beeswax in olive oil and mixing with lecithin to obtain an oil phase; 4) The aqueous phase obtained in step 2) is mixed with the oil phase obtained in step 3), and then mixed with retinoic acid cream and finger lemon essential oil to obtain a cream.

6. The preparation method according to claim 5, characterized in that: The jamu seeds described in step 1) are dried and then crushed.

7. The preparation method according to claim 5 or 6, characterized in that: The temperature of the ethanol extraction is 50-55° C., the time of the ethanol extraction is 80-100 minutes, the mass ratio of the jamu fruit seeds to the ethanol is 1:(10-20), and the volume concentration of the ethanol is 60-80%.

8. The preparation method according to claim 7, characterized in that: The dissolving temperature is 50-55° C., and the dissolving time is 30-100 minutes.

9. The preparation method according to claim 5, characterized in that: In step 4), the water phase and the oil phase are mixed as follows: the water phase is divided into 3 to 5 portions and mixed with the oil phase in batches.

10. Use of the cream according to claim 4 or the cream prepared by the preparation method according to any one of claims 5 to 9 in preparing a medicament for preventing and / or treating acne.

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