Neutral bacteriostatic detergent composition based on salicylic acid and application thereof

Abstract

The invention relates to the field of detergents, and discloses a neutral bacteriostatic detergent composition based on salicylic acid and application thereof. The neutral bacteriostatic detergent composition comprises 5-20% of a surfactant, 0.5-2% of glycerin fatty acid ester, 0.2-2% of salicylic acid, a pH regulator and water, the pH value of a 10wt% aqueous solution of the neutral bacteriostatic detergent composition is 6.0-8.0. The antibacterial ability of salicylic acid under the neutral condition is improved through a certain content of fatty glyceride for the first time, and the content of salicylic acid in a neutral system can be remarkably reduced. The compound combination of fatty glyceride and salicylic acid can be applied to a plurality of washing scenes, and especially has an excellent inhibition effect on main pet pathogenic bacteria such as staphylococcus pseudointermediates, microsporum canis, malassezia, candida albicans and the like.

Description

Technical Field

[0001] The present invention relates to the field of detergents, and in particular to a neutral antibacterial detergent composition based on salicylic acid and application thereof. Background Art

[0002] With the growing pursuit of high-quality life by consumers, the requirements for market products are also getting higher and higher; for example, consumers currently have certain antibacterial effects on daily laundry detergent, shampoo and other products; especially for pet-raising families, pet owners themselves increase the risk of microbial infection. In general, pet skin diseases come from bacterial and fungal skin diseases. The bacteria that cause infection are mainly Staphylococcus intermedia; and the fungi are mainly Microsporum canis, Malassezia, etc.; and pets are affected by pathogenic bacteria on their owners, such as Malassezia, Candida albicans, etc. In addition, the pathogenic bacteria carried by pets themselves appear in every scene in life, such as clothing or skin, mattresses, sofas, floors, tableware, etc. brought in by pet owners when petting cats and dogs; therefore, when pet owners use household cleaners, laundry detergents, shower gels or pet bath shampoos and other products, all-round antibacterial is necessary, and they need to have excellent inhibition capabilities against multiple species at the same time.

[0003] Common types of antibacterial agents include triclosan, benzalkonium chloride, polyhexamethylene biguanide, para-chloro-meta-xylenol, silver ions, etc. However, existing antibacterial agents still have several defects: First, triclosan and para-chloro-meta-xylenol have certain safety risks and are not suitable for pets with sensitive bodies; second, benzalkonium chloride and polyhexamethylene biguanide cationic antibacterial agents are limited by the surfactant system, and usually the anionic surfactant system makes the product's antibacterial effect worse and the stability poor; third, silver ions are affected by the surfactant system and are prone to discoloration; fourth, there is no suitable antibacterial component for multi-scenario application. Fifth, the antibacterial ability of a single ingredient is insufficient.

[0004] Salicylic acid is an organic acid widely used in food, daily chemicals, medicine and other product fields, and can be used in a variety of daily chemical products; however, salicylic acid can only achieve a good antibacterial effect in the formulation of an acidic system. When the pH of the formulation system is greater than 5.0, the antibacterial effect of salicylic acid is greatly reduced. In the prior art, for example, in the patent "CN114983864B A Salicylic Acid Transparent Shower Gel of Suspended System and Preparation Method thereof", the pH value of the shower gel is preferably controlled between 3-5 in order to better exert the efficacy of salicylic acid; in the patent "CN114917135B A Shampoo Based on Salicylic Acid and Sulfur and Preparation Method thereof", 0.1-2% salicylic acid is used alone as an anti-dandruff agent, and the system is set to an acidic environment to achieve an anti-dandruff effect.

[0005] Based on the above analysis, although salicylic acid has the potential to be used in multiple cleaning products, household cleaners, laundry detergents or pet bath shampoos for pets require neutrality, mildness, low irritation, and inhibition of multiple bacteria, which makes the application of salicylic acid very limited; therefore, it is necessary to find an antibacterial composition containing salicylic acid to achieve efficient antibacterial effect under a neutral system. Summary of the invention

[0006] In order to solve the above technical problems, the present invention provides a neutral antibacterial detergent composition based on salicylic acid and application thereof.

[0007] The present invention is the first to enhance the antibacterial ability of salicylic acid under neutral conditions by using a certain amount of fatty acid glycerides, which can significantly reduce the content of salicylic acid in a neutral system. This compound combination of fatty acid glycerides and salicylic acid can be used in multiple washing scenarios, especially for major pet pathogens such as Staphylococcus pseudintermedius, Microsporum canis, Malassezia, Candida albicans, etc. It has excellent inhibitory effects.

[0008] The specific technical scheme of the present invention is: In a first aspect, the present invention provides a neutral antibacterial detergent composition based on salicylic acid, comprising the following components in mass percentage: 5-20% surfactant, 0.5-2% glycerol fatty acid ester, 0.2-2% salicylic acid, pH regulator and water. Wherein, the pH of a 10wt% aqueous solution of the neutral antibacterial detergent composition is 6.0-8.0.

[0009] In the formula of the present invention, salicylic acid is used as an antibacterial component, and its antibacterial effect is mainly due to the use of undissociated molecules. They are highly lipophilic and can easily penetrate the cell membrane structure, interfere with the permeability of the microbial cell membrane, hinder the absorption of amino acids by the cell membrane, and enter the organic acid molecules in the cell. It is also very easy to react with free amino groups and bases in the cell body, change the internal environment of the bacteria, inhibit the activity of the respiratory enzyme system in the microbial cells, and finally kill them, thereby playing an antibacterial role. The stronger the acidity in the washing environment, the higher the concentration of undissociated salicylic acid molecules, and the better the antibacterial effect; while under neutral conditions, the concentration of undissociated salicylic acid molecules decreases, resulting in a decrease in the antibacterial effect. Therefore, in the prior art, the neutral washing environment usually needs to increase the amount of salicylic acid added to increase the undissociated salicylic acid content, so as to achieve the expected antibacterial effect, but the high-content salicylic acid system has problems such as large irritation and poor stability.

[0010] To this end, the present invention team accidentally discovered in the experiment that the introduction of an appropriate amount of glycerol fatty acid esters into a neutral antibacterial detergent containing salicylic acid can significantly improve the antibacterial properties of salicylic acid at low levels. Through further research, we analyzed the reasons for this: (1) First, glycerol fatty acids themselves also have certain antibacterial functions, and their antibacterial mechanism is to change the permeability and integrity of the cell membrane, diffuse through the cell wall, collapse the cell membrane and interfere with the intracellular contents; ultimately, glycerol fatty acids and salicylic acid produce a synergistic effect after compounding, resulting in an antibacterial effect of "1+1>2"; (2) Secondly, the present inventors further discovered that sorbitan fatty acid esters with similar structures also have good antibacterial effects, and their antibacterial mechanism is the same as that of glycerol fatty acid esters. Although they can improve the antibacterial effect of salicylic acid, the improvement is very limited, and the antibacterial effect on Staphylococcus pseudointermedius and Candida albicans is poor, and the efficient antibacterial effect cannot be achieved. The present invention team thus inferred that glycerol fatty acids can significantly improve the antibacterial ability of salicylic acid in a neutral washing environment, and there are other factors besides their own antibacterial properties.

[0011] For this reason, the inventor further analyzes glycerol fatty acid ester; On the one hand, glycerol fatty acid ester has lipophilicity, and its affinity with bacterial cell membrane is good, and it is easy to approach the surface of pathogenic bacteria cell membrane. On the other hand, glycerol fatty acid ester has certain emulsifying properties, and it can emulsify with undissociated salicylic acid, and substitute undissociated salicylic acid into the surface of bacterial cell membrane, so that the concentration of salicylic acid molecules on the surface of bacterial cell membrane is increased to achieve the expected antibacterial effect. Therefore, glycerol fatty acid ester with certain lipophilicity and emulsification at the same time can make undissociated salicylic acid molecules further play an efficient antibacterial effect. When sorbitan fatty acid ester replaces glycerol fatty acid ester, the number of hydroxyl groups changes, and hydrophilicity is strengthened, resulting in insufficient antibacterial effect of the composition.

[0012] Preferably, the neutral antibacterial detergent composition comprises the following components in mass percentage: 5-15% surfactant, 0.5-1.5% glycerol fatty acid ester, 0.2-1.5% salicylic acid, pH regulator and water. The pH of a 10 wt % aqueous solution of the neutral antibacterial detergent composition is 6.0-8.0.

[0013] The content of surfactant not only affects the stability of the formula, but also affects the antibacterial effect of the combination of salicylic acid and glyceryl fatty acid esters; when the surfactant content is low, the stability of the product is prone to negative effects such as turbidity or stratification; when the surfactant content is high, salicylic acid and glyceryl fatty acid esters are solubilized into the water phase due to the excessive solubilization effect, resulting in a low salicylic acid content near the bacterial cell membrane, resulting in insufficient antibacterial effect.

[0014] Preferably, the glycerol fatty acid ester includes one or more of glycerol caprylate, glycerol caprate and glycerol laurate. Further preferably, the glycerol fatty acid ester is one or both of glycerol caprylate and glycerol caprate. In addition, preferably, the mass ratio of the glycerol fatty acid ester to salicylic acid is 1 to 3:1; further preferably, the mass ratio of the glycerol fatty acid ester to salicylic acid is 1 to 2:1.

[0015] As mentioned above, glycerol fatty acid esters with certain lipophilicity and emulsification properties can enable undissociated salicylic acid molecules to further exert efficient antibacterial effects. Therefore, different types of glycerol fatty acid esters have different effects on improving the antibacterial ability of salicylic acid. The present invention found that: (1) Glycerol caprylate, glycerol caprate and glycerol laurate have better effects, especially glycerol caprylate and glycerol capric acid. When the fatty carbon chain in the glycerol fatty acid ester is too long, its emulsification performance and self-antibacterial performance decrease, resulting in insufficient antibacterial effect; when the fatty acid carbon chain is too short, its lipophilicity decreases, resulting in insufficient antibacterial effect. (2) The mass ratio of glycerol fatty acid ester to salicylic acid is 1 to 3:1, especially the mass ratio of glycerol fatty acid ester to salicylic acid is 1 to 2:1. When the mass ratio of glycerol fatty acid ester to salicylic acid is too low, the ability of glycerol fatty acid ester to bring salicylic acid molecules into the bacterial cell membrane is limited; when the mass ratio of glycerol fatty acid ester to salicylic acid is too high, it is speculated that the possible reason is that the limited salicylic acid content is not enough to achieve an efficient antibacterial effect, or the glycerol fatty acid ester content is too high and preferentially approaches the bacterial cell membrane, resulting in fewer salicylic acid molecules nearby.

[0016] Preferably, the surfactant includes one or more of anionic surfactants, amphoteric surfactants and nonionic surfactants.

[0017] Preferably, the anionic surfactant includes one or more of sodium laureth sulfate, sodium linear alkylbenzene sulfonate, sodium cocoyl aminopropionate and sodium lauroyl methyl taurate.

[0018] Preferably, the amphoteric surfactant includes one or more of cocamidopropyl betaine, sodium cocoamphoacetate and dodecylamine oxide.

[0019] Preferably, the nonionic surfactant is one or more of fatty alcohol polyoxyethylene ether AEO-9, fatty alcohol polyoxyethylene ether AEO-7, lauryl glucoside and coconut glucoside.

[0020] Preferably, the neutral antibacterial detergent composition is a household cleaner or laundry detergent, and further comprises one or more of an anti-dye transfer agent, an anti-redeposition agent, a fluorescent brightener, a fragrance, a chelating agent and a pigment.

[0021] Preferably, the neutral antibacterial detergent composition is a shampoo, a shower gel or a pet bath shampoo, and further comprises one or more of a cationic conditioner, a silicone oil conditioner, a moisturizer, a fragrance, a chelating agent and a pigment.

[0022] In a second aspect, the present invention provides the use of the above-mentioned neutral antibacterial detergent composition in simultaneously inhibiting Microsporum canis, Staphylococcus pseudintermedius, Malassezia and Candida albicans.

[0023] As described in the background technology section of this application, for pet-raising families, pet skin diseases generally come from bacterial and fungal skin diseases, and the bacteria that cause infection are mainly Staphylococcus intermedius; and the fungi are mainly Microsporum canis, Malassezia, Candida albicans, etc. Therefore, when the neutral antibacterial detergent composition of the present invention is used as a washing product involving pets such as pet bath shampoo, it is necessary to have particularly excellent inhibitory ability against the four fungi of Microsporum canis, Staphylococcus pseudointermedius, Malassezia and Candida albicans at the same time.

[0024] Compared with the prior art, the beneficial effects of the present invention are: (1) The present invention first discovered that the introduction of a certain amount of fatty acid glyceride can significantly enhance the antibacterial ability of salicylic acid in a neutral washing environment, thereby significantly reducing the content of salicylic acid in a neutral system. The problem of insufficient antibacterial activity of salicylic acid under neutral conditions is solved; the detergent composition has the characteristics of high antibacterial efficiency, mild and low irritation, and good stability.

[0025] (2) The present invention can further enhance the effect of fatty acid glycerides on the antibacterial ability of salicylic acid in a neutral detergent environment by optimizing the type and content of fatty acid glycerides.

[0026] (3) The surfactant system of the neutral antibacterial detergent composition of the present invention is also suitable for products such as dishwashing detergents, laundry detergents, shampoos, pet bath shampoos, etc., meeting the conditions of use in multiple scenarios, especially for pet-raising families; it has a particularly effective inhibitory effect on pathogenic bacteria carried by pets, such as Staphylococcus pseudintermedius, Microsporum canis, Malassezia and Candida albicans. DETAILED DESCRIPTION

[0027] The present invention will be further described below in conjunction with the embodiments.

[0028] Overall embodiment In a first aspect, the present invention provides a neutral antibacterial detergent composition based on salicylic acid, comprising the following components in mass percentage: 5-20% surfactant, 0.5-2% glycerol fatty acid ester, 0.2-2% salicylic acid, pH regulator and water. Wherein, the pH of a 10wt% aqueous solution of the neutral antibacterial detergent composition is 6.0-8.0.

[0029] In some preferred implementation cases, the neutral antibacterial detergent composition comprises the following components in mass percentage: 5-15% surfactant, 0.5-1.5% glycerol fatty acid ester, 0.2-1.5% salicylic acid, pH regulator and water. Wherein, the pH of a 10wt% aqueous solution of the neutral antibacterial detergent composition is 6.0-8.0.

[0030] In some preferred implementation cases, the glycerol fatty acid ester includes one or more of glycerol caprylate, glycerol caprate and glycerol laurate. In some more preferred implementation cases, the glycerol fatty acid ester is one or both of glycerol caprylate and glycerol caprate.

[0031] In some preferred implementation cases, the mass ratio of the glycerol fatty acid ester to salicylic acid is 1-3:1; in some more preferred implementation cases, the mass ratio of the glycerol fatty acid ester to salicylic acid is 1-2:1.

[0032] In some preferred implementation cases, the surfactant includes one or more of anionic surfactants, amphoteric surfactants and nonionic surfactants.

[0033] In some preferred implementation cases, the anionic surfactant includes one or more of sodium laureth sulfate, sodium linear alkylbenzene sulfonate, sodium cocoyl aminopropionate and sodium lauroyl methyl taurate.

[0034] In some preferred implementation cases, the amphoteric surfactant includes one or more of cocamidopropyl betaine, sodium cocoamphoacetate and dodecylamine oxide.

[0035] In some preferred implementation cases, the nonionic surfactant is one or more of fatty alcohol polyoxyethylene ether AEO-9, fatty alcohol polyoxyethylene ether AEO-7, lauryl glucoside and coconut glucoside.

[0036] In some preferred implementation cases, the neutral antibacterial detergent composition is a dishwashing detergent, and its surfactant is preferably one or more of dodecylamine oxide, fatty alcohol polyoxyethylene ether AEO-9, and sodium lauryl polyether sulfate.

[0037] In some preferred implementation cases, the neutral antibacterial detergent composition is a laundry detergent, and its surfactant is preferably one or more of sodium lauryl polyether sulfate, sodium linear alkyl benzene sulfonate and fatty alcohol polyoxyethylene ether AEO-9.

[0038] In some preferred implementation cases, the neutral antibacterial detergent composition is a shampoo, a shower gel or a pet bath shampoo, and its surfactant is preferably one or more of sodium laureth sulfate, cocamidopropyl betaine and lauryl glucoside.

[0039] In some preferred implementation cases, the neutral antibacterial detergent composition is a household cleaner or laundry detergent, and further comprises one or more of an anti-dye transfer agent, an anti-redeposition agent, a fluorescent whitening agent, a fragrance, a chelating agent and a pigment.

[0040] In some preferred implementation cases, the neutral antibacterial detergent composition is a shampoo, a shower gel or a pet bath shampoo, and further comprises one or more of a cationic conditioner, a silicone oil conditioner, a moisturizer, a fragrance, a chelating agent and a pigment.

[0041] In a second aspect, the present invention provides the use of the above-mentioned neutral antibacterial detergent composition in simultaneously inhibiting Microsporum canis, Staphylococcus pseudintermedius, Malassezia and Candida albicans.

[0042] Test Method <Antibacterial performance>: The antibacterial performance refers to the GB / T 2738 suspension quantitative method, and the test conditions are: the action concentration is 50% and the action time is 10 minutes.

[0043] <Irritation performance>: The irritation performance was tested using the zein method, and the test conditions were: the action concentration was 10%; according to literature reports, the irritation level is divided into 3 levels: Level 1: Zein value > 4g / L, indicating strong irritation; Level 2: 2g / L≤≤Zein value≤≤4g / L, indicating low irritation; Level 3: Zein value <2g / L, indicating no irritation.

[0044] <Stability>: Stability is evaluated at -5℃ and 45℃ for one week, and the product appearance is observed.

[0045] Specific Examples and Comparative Examples The surfactant system of shampoo, shower gel or pet shampoo was used for experimental comparison.

[0046] (I) The antibacterial properties of salicylic acid under different pH conditions were verified by Comparative Examples 1 to 10 and Examples 1 and 2. The formulas of the detergent compositions of the comparative examples and examples and the test results are shown in Tables 1 and 2, respectively.

[0047] Table 1: Performance test results of salicylic acid under different pH conditions The allocation ratios of each group and the performance test results of Comparative Examples 7 to 10 and Examples 1 and 2 are shown in Table 2.

[0048] Table 2: Performance test results of salicylic acid at different composition ratios According to the test results of Comparative Examples 1 to 10 and Examples 1 and 2, it can be concluded that: (1) Under the same acidic conditions (Comparative Examples 1 to 3), the higher the concentration of salicylic acid in the detergent composition, the better the inhibitory effect on the four pathogens listed in the table, and the stronger the irritation.

[0049] (2) Under the condition of the same concentration of salicylic acid (Comparative Examples 4 to 6, 7 and 8), the antibacterial effect of the detergent composition decreases with the increase of pH value, especially for Staphylococcus pseudintermedius and Candida albicans, the decrease is greater. Under neutral conditions, only when the salicylic acid concentration in the system reaches 3% (Comparative Example 9) can it show excellent antibacterial properties, but there is a significant problem of increased irritation.

[0050] (3) Under neutral conditions, when glyceryl caprylate was additionally added to a detergent composition containing 1% salicylic acid (Examples 1 and 2), it exhibited excellent antibacterial properties, with an antibacterial rate of >99% against four pathogenic bacteria; while the antibacterial performance of the group containing only 1% glyceryl caprylate but no salicylic acid (Comparative Example 10) was poor. Therefore, it can be concluded that single glyceryl caprylate does not have excellent antibacterial properties, but after introducing an appropriate amount of glyceryl caprylate into a neutral system detergent containing salicylic acid, the antibacterial ability of salicylic acid can be greatly improved. Therefore, the addition of glyceryl caprylate can greatly reduce the content of salicylic acid in a neutral system, thereby reducing the irritation of the detergent composition.

[0051] (II) Effects of salicylic acid and glyceryl caprylate in different proportions The component proportions and performance test results of the antibacterial detergent compositions of Examples 3 to 7 and Comparative Examples 11 and 12 are shown in Table 3.

[0052] Table 3: Allocation ratio of each group and performance test results According to the test results of Examples 3 to 7 and Comparative Examples 11 and 12, it can be concluded that when salicylic acid and glyceryl caprylate are compounded at a suitable ratio (1:1-3), under neutral conditions, they exhibit efficient antibacterial performance, and the irritation is non-irritating, and the stability is good. When salicylic acid and glyceryl caprylate are compounded at a ratio lower than the specific ratio (Comparative Example 11), the antibacterial effect is obviously insufficient, especially for Staphylococcus pseudintermedius and Candida albicans. When salicylic acid and glyceryl caprylate are compounded at a ratio higher than the specific ratio (Comparative Example 12), the antibacterial effect is insufficient and the stability is deteriorated.

[0053] (III) Effects of salicylic acid and different types of glycerol fatty acid esters The component proportions and performance test results of the antibacterial detergent compositions of Examples 8 to 10 and Comparative Examples 13 to 15 are shown in Table 4.

[0054] Table 4: Allocation ratio of each group and performance test results According to the test results of Examples 8 to 10 and Comparative Examples 13 to 15, it can be concluded that when salicylic acid is compounded with different types of glycerol fatty acid esters, the antibacterial effects exhibited under neutral conditions are significantly different. Specifically, when salicylic acid is compounded with glycerol caprylate (Example 8) or glycerol caprate (Example 9) or glycerol laurate (Example 10), they all exhibit efficient antibacterial effects, and the antibacterial rates against 4 bacteria are > 99%; when salicylic acid is compounded with glycerol stearate (Comparative Example 13), the antibacterial effect is acceptable, but the stability is poor, and the 4 bacteria cannot simultaneously achieve a 99% antibacterial effect; when salicylic acid is compounded with sorbitan caprylate (Comparative Example 14) or polyglycerol fatty acid ester (Comparative Example 15), the antibacterial effect is poor, mainly due to the influence of emulsification properties and lipophilicity.

[0055] (IV) Testing of different detergent product types The performance test results of the dishwashing detergent formulation components of Example 11 and Example 12 and Comparative Example 17, and the laundry detergent formulation components of Example 13 and Example 14 and Comparative Example 18 are shown in Table 5.

[0056] Table 5: Allocation ratio of each group and performance test results According to the test results of Examples 11 to 14, it can be concluded that when the surfactant system is applied to dishwashing detergent and laundry detergent products, the antibacterial rate of salicylic acid and glyceryl caprylate or glyceryl laurate against four pathogenic bacteria is greater than 99%, which meets the use scenario of pet-raising families and solves the pet owner's concerns about pathogenic bacteria on pets when washing dishes or laundry. At the same time, according to Comparative Examples 17-18, it is found that when the surfactant content is too low (Comparative Example 17) or too high (Comparative Example 18), it will lead to problems such as poor stability or poor antibacterial effect.

[0057] The performance test results of the formulas of the complete laundry detergents of Examples 15-16 and the complete pet bath shampoo of Examples 17-18 are shown in Table 6.

[0058] Table 6: Allocation ratio of each group and performance test results According to the test results of Examples 15 to 18, salicylic acid and glycerol fatty acid esters in complete laundry detergent and pet bath shampoo formulas show efficient antibacterial performance, and the antibacterial rates against Microsporum canis, Staphylococcus pseudointermedius, Malassezia and Candida albicans are greater than 99%. Therefore, the neutral antibacterial detergent composition has the characteristics of efficient antibacterial performance, mild and low irritation, and good stability.

[0059] In summary, the neutral antibacterial detergent composition based on salicylic acid of the present invention has the following advantages compared with the prior art: (1) The present invention first discovered that the introduction of a certain amount of fatty acid glyceride can significantly enhance the antibacterial ability of salicylic acid in a neutral washing environment, thereby significantly reducing the content of salicylic acid in a neutral system. The problem of insufficient antibacterial activity of salicylic acid under neutral conditions is solved; the detergent composition has the characteristics of high antibacterial efficiency, mild and low irritation, and good stability.

[0060] (2) The present invention can further enhance the effect of fatty acid glycerides on the antibacterial ability of salicylic acid in a neutral detergent environment by optimizing the type of fatty acid glycerides and strictly limiting their content.

[0061] (3) The surfactant system of the neutral antibacterial detergent composition based on salicylic acid of the present invention is also suitable for products such as dishwashing detergents, laundry detergents, shampoos, pet bath shampoos, etc., meeting the conditions of use in multiple scenarios, especially for pet-raising families; it has a particularly effective inhibitory effect on pathogenic bacteria carried by pets, such as Staphylococcus pseudintermedius, Microsporum canis, Malassezia and Candida albicans.

[0062] The raw materials and equipment used in the present invention, unless otherwise specified, are all commonly used raw materials and equipment in the art; the methods used in the present invention, unless otherwise specified, are all conventional methods in the art.

[0063] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any way. Any simple modification, change and equivalent transformation made to the above embodiment based on the technical essence of the present invention still falls within the protection scope of the technical solution of the present invention.

Claims

1. A neutral antibacterial detergent composition based on salicylic acid, characterized in that: The invention comprises the following components in percentage by mass: 5-20% surfactant, 0.5-2% glycerol fatty acid ester, 0.2-2% salicylic acid, pH regulator and water; The pH of a 10 wt % aqueous solution of the neutral antibacterial detergent composition is 6.0-8.

0.

2. The neutral antibacterial detergent composition according to claim 1, characterized in that: The invention comprises the following components in percentage by mass: 5-15% surfactant, 0.5-1.5% glycerol fatty acid ester, 0.2-1.5% salicylic acid, pH regulator and water; The pH of a 10 wt % aqueous solution of the neutral antibacterial detergent composition is 6.0-8.

0.

3. The neutral antibacterial detergent composition according to claim 1 or 2, characterized in that: The glycerol fatty acid ester includes one or more of glycerol caprylate, glycerol caprate and glycerol laurate.

4. The neutral antibacterial detergent composition according to claim 1 or 2, characterized in that: The mass ratio of the glycerol fatty acid ester to salicylic acid is 1-3:

1.

5. The neutral antibacterial detergent composition according to claim 1 or 2, characterized in that: The surfactant includes one or more of anionic surfactants, amphoteric surfactants and nonionic surfactants.

6. The neutral antibacterial detergent composition according to claim 5, characterized in that: The anionic surfactant includes one or more of sodium laureth sulfate, sodium linear alkylbenzene sulfonate, sodium cocoyl aminopropionate and sodium lauroyl methyl taurate.

7. The neutral antibacterial detergent composition according to claim 5, characterized in that: The amphoteric surfactant includes one or more of cocamidopropyl betaine, sodium cocoamphoacetate and lauryl amine oxide.

8. The neutral antibacterial detergent composition according to claim 5, characterized in that: The nonionic surfactant is one or more of fatty alcohol polyoxyethylene ether AEO-9, fatty alcohol polyoxyethylene ether AEO-7, lauryl glucoside and coconut glucoside.

9. The neutral antibacterial detergent composition according to claim 1 or 2, characterized in that: The neutral antibacterial detergent composition is a household cleaner or laundry detergent, and further comprises one or more of an anti-dye transfer agent, an anti-redeposition agent, a fluorescent brightener, a fragrance, a chelating agent and a pigment; or The neutral antibacterial detergent composition is a shampoo, a shower gel or a pet bath shampoo, and further comprises one or more of a cationic conditioner, a silicone oil conditioner, a moisturizer, a fragrance, a chelating agent and a pigment.

10. Use of the neutral antibacterial detergent composition according to any one of claims 1 to 9 in simultaneously inhibiting Microsporum canis, Staphylococcus pseudintermedius, Malassezia and Candida albicans.

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