Collection device, blood glucose meter and blood glucose detection method

Abstract

The invention discloses a collection device, a blood glucose meter and a blood glucose detection method. The acquisition device comprises a microneedle and an optical fiber, the microneedle is provided with a center hole, and the microneedle is used for penetrating into a measured object; the optical fiber is used for emitting detection light to a detected object through the center hole and receiving an optical signal excited by the detected object through the center hole. Thus, the microneedle is inserted into the object to be detected, the collecting device can be in stable and effective contact with the object to be detected, stable collecting signals are obtained, the signal-to-noise ratio of the collecting signals is increased, and therefore the accuracy and precision of blood glucose concentration detection are improved.

Description

Technical Field

[0001] The present application relates to the field of medical equipment, and in particular to a blood glucose collection device, a blood glucose meter and a blood glucose detection method. Background Art

[0002] Blood glucose testers usually use lasers to emit lasers to the object being measured, and receive the light excited by the object being measured, so as to calculate and determine the blood glucose concentration of the object being measured based on the light. In the related art, in order to improve the penetration of the object being measured, the laser emitted by the blood glucose tester usually uses near-infrared light. However, the signal collected by this blood glucose tester is unstable and has a low signal-to-noise ratio, which reduces the accuracy of blood glucose concentration detection. Summary of the invention

[0003] The present application provides a collection device, a blood glucose meter and a blood glucose detection method.

[0004] The collection device of the embodiment of the present application is used for a blood glucose meter, and the collection device includes a microneedle and an optical fiber. The microneedle is used to penetrate the object to be measured; one end face of the optical fiber faces or is located inside the microneedle, and is used to emit detection light to the object to be measured through the needle tip of the microneedle, and is used to receive light signals excited by the object to be measured through the needle tip of the microneedle.

[0005] The blood glucose meter of the embodiment of the present application includes the collection device and the light source of the above embodiment, and the light source is used to generate detection light.

[0006] The blood glucose detection method of the present application embodiment includes:

[0007] The optical signal excited by the object to be measured is received by the collecting optical fiber, and the optical signal is excited by the detection light; the detection light is emitted from the optical fiber through the central hole of the microneedle to the object to be measured, and the microneedle is inserted into the object to be measured;

[0008] The optical signal is processed to obtain the blood glucose concentration.

[0009] The collection device and blood glucose meter of the embodiments of the present application can be inserted into the object to be measured through the microneedle, stably and effectively contact the object to be measured, obtain a stable collection signal, improve the signal-to-noise ratio of the collection signal, and thus improve the accuracy and precision of blood glucose concentration detection.

[0010] Additional aspects and advantages of the present application will be given in part in the description below, and in part will become apparent from the description below, or will be learned through the practice of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0011] The above and / or additional aspects and advantages of the present application will become apparent and easily understood from the description of the embodiments in conjunction with the following drawings, in which:

[0012] Figure 1is a schematic diagram of the structure of a blood glucose meter according to an embodiment of the present application;

[0013] Figure 2 It is a structural schematic diagram of a collection device according to one embodiment of the present application;

[0014] Figure 3 It is a structural schematic diagram of a collection device according to another embodiment of the present application;

[0015] Figure 4 It is a structural schematic diagram of a collection device according to another embodiment of the present application;

[0016] Figure 5 It is a structural schematic diagram of a collection device according to another embodiment of the present application;

[0017] Figure 6 It is a structural schematic diagram of a collection device according to another embodiment of the present application;

[0018] Figure 7 It is a structural schematic diagram of a collection device according to another embodiment of the present application;

[0019] Figure 8 It is a structural schematic diagram of a collection device according to another embodiment of the present application;

[0020] Fig. 9 It is a structural schematic diagram of a collection device according to another embodiment of the present application;

[0021] Fig.10 It is a structural schematic diagram of a collection device according to another embodiment of the present application;

[0022] Fig.11 It is a structural schematic diagram of a collection device according to another embodiment of the present application;

[0023] Fig.12 It is a structural schematic diagram of a collection device according to another embodiment of the present application;

[0024] Fig.13 It is a structural schematic diagram of a collection device according to another embodiment of the present application;

[0025] Fig.14 It is a structural schematic diagram of a collection device according to another embodiment of the present application;

[0026] Fig.15 It is a structural schematic diagram of a collection device according to another embodiment of the present application;

[0027] Fig.16 It is a structural schematic diagram of a collection device according to another embodiment of the present application;

[0028] Fig.17is an enlarged schematic diagram of the structure of a microneedle according to an embodiment of the present application;

[0029] Fig.18 It is a structural schematic diagram of a collection device according to another embodiment of the present application;

[0030] Fig.19 It is a flow chart of the blood glucose detection method according to the embodiment of the present application.

[0031] Description of main component symbols:

[0032] Blood glucose meter 1000, collection device 100, microneedle 10, central hole 11, orifice 111, needle head 12, inner wall 13, beam splitter 14, dichroic mirror 141, focusing structure 15, round bead 151, optical fiber 20, first optical fiber 21, second optical fiber 22, third optical fiber 23, housing 30, object to be measured 200, light source 300, processing device 400, spectrometer 401, computer 402. DETAILED DESCRIPTION

[0033] The embodiments of the present application are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present application, and cannot be understood as limiting the present application.

[0034] In the description of the present application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present application. In addition, the terms "first" and "second" are only used for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present application, the meaning of "multiple" is two or more, unless otherwise clearly and specifically defined.

[0035] In the description of this application, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, an electrical connection, or mutual communication; it can be a direct connection, or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0036] In the present application, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may include that the first and second features are in direct contact, or may include that the first and second features are not in direct contact but are in contact through another feature between them. Moreover, a first feature being "above", "above" and "above" a second feature includes that the first feature is directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. A first feature being "below", "below" and "below" a second feature includes that the first feature is directly below and obliquely below the second feature, or simply indicates that the first feature is lower in level than the second feature.

[0037] The disclosure below provides many different embodiments or examples to realize the different structures of the present application. In order to simplify the disclosure of the present application, the parts and settings of specific examples are described below. Of course, they are only examples, and the purpose is not to limit the present application. In addition, the present application can repeat reference numbers and / or reference letters in different examples, and this repetition is for the purpose of simplification and clarity, and does not indicate the relationship between the various embodiments and / or settings discussed in itself. In addition, the various specific processes and examples of materials provided in the present application, but those of ordinary skill in the art can realize the application of other processes and / or the use of other materials.

[0038] See also Figure 1 The present application discloses a blood glucose meter 1000, which includes a collection device 100 and a light source 300. The light source 300 can output a light signal to a measured object 200 through the collection device 100. Specifically, the blood glucose meter 1000 can be used to detect blood glucose concentration in biological tissues, such as human bodies, animals, and other living organisms.

[0039] The collection device 100 is the input and output port of the blood glucose meter 1000 signal, and can act on the exposed organs of a living body. For example, the collection device 100 is close to the surface of human skin, and the light signal of the light source 300 is emitted into the subcutaneous tissue to collect the light signal reflected by the interstitial fluid under the skin. The blood glucose meter 1000 can analyze the light signal collected by the collection device 100 and calculate the blood glucose content by establishing a model relationship between the light signal and the blood glucose concentration.

[0040] The blood glucose meter 1000 can be manufactured in different sizes and with different precisions. It is suitable for use in homes, hospitals, clinics, nursing homes and other scenarios. It can be used for daily blood glucose testing by diabetic patients, as well as for physical examinations of healthy people and blood glucose testing of laboratory animals.

[0041] See also Figure 1-Figure 18 The collection device 100 of the embodiment of the present application includes a microneedle 10 and an optical fiber 20. The microneedle 10 is used to pierce the object 200 to be measured; one end face of the optical fiber 20 faces or is located inside the microneedle 10, and is used to emit detection light to the object 200 to be measured through the needle head 12 of the microneedle 10, and is used to receive the optical signal excited by the object 200 to be measured through the needle head 12 of the microneedle 10.

[0042] The blood glucose meter 1000 and the collection device 100 of the embodiment of the present application can be inserted into the object to be measured 200 through the microneedle 10, thereby avoiding the attenuation of the detection light on the surface of the object to be measured 200, making it easier for the detection light to identify glucose molecules, thereby obtaining a more efficient and stable collection signal, while avoiding the interference of scattered light, reflected light and ambient light generated on the surface of the object to be measured 200 on the detection light, thereby improving the signal-to-noise ratio of the collection signal, and thereby improving the accuracy and precision of blood glucose concentration detection.

[0043] For example, the collection device 100 can use Raman spectroscopy to measure blood sugar concentration. The principle of Raman spectroscopy for measuring blood sugar is that when the detection light is incident on the object to be measured 200, the molecular vibration energy is superimposed on the incident photon energy, causing the energy change of the photon, generating Raman scattered light, and identifying the vibration structure of the measured molecule through Raman spectroscopy. Glucose molecules can be used as a measured molecule, which is excited by the detection light to generate Raman scattered light. In the following description, human tissue will be used as the object to be measured 200, and the collection device will use Raman spectroscopy to measure the concentration of glucose molecules in the blood.

[0044] The collection device 100 is covered on the surface of the skin, and the microneedle is inserted into the subcutaneous tissue. The detection light is transmitted through the optical fiber 20 and passes through the inside of the microneedle 10 into the subcutaneous tissue. The subcutaneous tissue contains blood vessels, among which the capillaries can be located in the superficial tissue under the skin. The glucose molecules in the capillaries can travel in the blood. The detection light is injected into the capillaries, exciting the glucose molecules to produce Raman scattered light. The excited Raman scattered light is received by the optical fiber 20 as a collection light signal, and is transmitted to the outside of the collection device 100 through the microneedle 10. The collection light signal carries the structure and concentration information of the glucose molecule. After receiving the light signal, the blood glucose meter 1000 analyzes and processes the information therein to obtain the blood glucose concentration.

[0045] The blood glucose detection device in the related art uses detection light to enter from outside the object to be tested, excite the molecules in the object to be tested and collect the reflected signals, and calculate the blood glucose concentration through the reflected signal analysis. Since the skin tissue has a high absorption rate for mid-infrared light, the penetration and detection depth of mid-infrared light is limited, and the Raman spectrum signal generated by near-infrared light with high penetration into skin tissue is weak, so the quality and specificity of the signal collected by the device are poor. At the same time, the Rayleigh scattered light and ambient light generated by the incident detection light not superimposed with the molecular vibration energy interfere with the reflected signal, reducing the signal-to-noise ratio. In addition, the light reflected or scattered from the surface of the object to be tested will further deteriorate the signal quality.

[0046] In addition, there is also a blood sugar detection device in the related technology that inserts a microneedle into the object to be tested and obtains the glucose concentration by analyzing the electrical signal generated by the electrochemical reaction between glucose and the biological enzyme on the microneedle. This device consumes a certain amount of biological enzymes for each test, and the microneedles also need to be replaced regularly as the biological enzymes are consumed, which is costly for users.

[0047] The microneedle 10 of the embodiment of the present application has a hollow structure (the hollow structure in the relevant embodiments of the present application can also be filled with some light-transmitting materials, such as transparent materials), and the needle head 12 part can have an inclined window to facilitate the insertion of the object to be measured 200. The microneedle 10 is generally made by a micro-machining process, and the size is in the micron level. The diameter of the needle head 12 can be 30-80μm. The end of the microneedle 10 can be open or closed, for example, the end of the microneedle 10 is sealed with plastic or glass. The plastic or glass used for sealing can be transparent so that the detection light can excite the molecules to be measured to achieve detection. The microneedle 10, especially the needle head 12 part that penetrates the object to be measured 200, can be made of materials with good biocompatibility, such as silicon, silicon dioxide, biodegradable polymers, or metals such as nickel and titanium.

[0048] The optical fiber 20 can be arranged in the hollow structure of the microneedle 10, and its diameter is smaller than the diameter of the microneedle 10, and it may not contact the inner wall 13 of the microneedle 10. The optical fiber 20 can be an optical fiber 20 capable of transmitting a specific wavelength to improve the specificity of the signal collected by the collection device 100, for example, a special optical fiber 20 for transmitting 1-12 μm infrared light. The optical fiber 20 can be made of a material with good infrared light transmission performance, for example, the optical fiber 20 can be made of chalcogenide glass.

[0049] In some embodiments, the optical fiber 20 corresponding to the microneedle 10 may include: one or more of a first optical fiber 21, a second optical fiber 22 and a third optical fiber 23 (for example, including the first optical fiber 21 and the second optical fiber 22, or including the third optical fiber 23, or including at least two of the first optical fiber 21, the second optical fiber 22 and the third optical fiber 23); when the number of microneedles 10 is multiple, the optical fiber 20 corresponding to each microneedle 10 may be the same or different; wherein the first optical fiber 21 is used to emit detection light, the second optical fiber 21 is used to receive an optical signal, and the first end of the third optical fiber 21 is used to receive the detection light separated by the spectrometer 14, so that the second end of the third optical fiber 21 emits the detection light; the second end of the third optical fiber 23 is used to receive an optical signal so that the optical signal is emitted to the spectrometer 14 through the first end of the third optical fiber 23, so that the spectrometer 14 transmits the optical signal.

[0050] Please refer to Figure 1-Figure 5 In some embodiments, the number of the microneedle 10 is one, and at least one optical fiber 20 is correspondingly provided to the microneedle 10 .

[0051] In this way, the microneedle 10 penetrates the object 200 to be measured, emits the detection light below the surface of the object 200 through the optical fiber 20, excites the glucose molecules in the object 200 to be measured, and receives the light signal emitted by the glucose molecules, thereby obtaining the information of the glucose molecules contained in the object 200 to be measured.

[0052] For example, the optical fiber 20 can be linear, with one end connected to the light source 300 that emits the detection light, and the other end can pass through the hollow structure of the microneedle 10 and approach the needle head 12 of the microneedle. The end of the optical fiber 20 close to the microneedle can also be set to face the hollow part in the microneedle 10 without extending into the microneedle 10. The optical fiber 20 can be set as one or a bundle. A bundle of optical fibers 20 includes two or more single optical fibers 20.

[0053] See also Figure 2 and Figure 5 In some embodiments, the number of microneedles 10 is one, the total number of optical fibers 20 is multiple, and the optical fibers include a first optical fiber 21 and a second optical fiber 22. The first optical fiber 21 is used to emit detection light, and the second optical fiber 22 is used to receive optical signals.

[0054] See also Figure 4 and Figure 5 In some embodiments, the total number of optical fibers 20 is multiple, and the optical fiber 20 may include a third optical fiber 23, which is used to emit detection light and receive optical signals.

[0055] In this way, the intensity and range of the emitted detection light are increased by increasing the number of optical fibers 20 for emitting detection light, and the intensity of the received signal is enhanced by increasing the number of optical fibers 20 for receiving optical signals, thereby improving the detection accuracy.

[0056] For example, the optical fiber 20 can perform unidirectional transmission, for example, Figure 1 In the illustrated embodiment, the first optical fiber 21 transmits the detection light from the light source to the needle tip 12 of the microneedle 10, and the second optical fiber 22 collects the optical signal from one end of the needle tip 12 and transmits it to the other end, which can be connected to the processing device 400 of the blood glucose meter 1000. The first optical fiber 21 and the second optical fiber 22 can be arranged side by side in the microneedle, and the directions of transmitting the optical signals are opposite. The optical fiber 20 can also have a bidirectional transmission function, for example, Figure 3 The third optical fiber 23 in the illustrated embodiment transmits the detection light from the outside of the microneedle 10 to the inside of the microneedle near the needle 12, and can simultaneously transmit the optical signal from one end near the needle 12 to the end where the detection light is input.

[0057] In one embodiment, please refer again to Figure 1 The collection device 100 has a microneedle 10 , in which a first optical fiber 21 and a second optical fiber 22 are arranged.

[0058] In one embodiment, please refer to Figure 2 The collection device 100 has a microneedle 10, and a plurality of first optical fibers 21 and a plurality of second optical fibers 22 are arranged in the microneedle 10. The plurality of first optical fibers 21 can be bundled into a bundle, and the plurality of second optical fibers 22 can be bundled into a bundle. The plurality of first optical fibers 21 and the plurality of second optical fibers 22 can also be dispersed inside the microneedle 10.

[0059] In one embodiment, please refer to Figure 4 The collection device 100 has a microneedle 10, and a plurality of third optical fibers 23 are arranged in the microneedle 10. The plurality of third optical fibers 23 can be bundled into a bundle. A bundle of third optical fibers 23 can collect optical signals from the object 200 and transmit them to the processing device 400 while injecting detection light into the object 200.

[0060] In one embodiment, please refer to Figure 5 The collection device 100 has a microneedle 10, and a first optical fiber 21, a second optical fiber 22, and a third optical fiber 23 are arranged in the microneedle 10. The first optical fiber 21 and the third optical fiber 23 are used to emit detection light, and the second optical fiber 22 and the third optical fiber 23 are used to receive optical signals.

[0061] In one embodiment, the collection device 100 has a microneedle 10 , and the microneedle 10 may include any two of the following optical fibers: a first optical fiber 21 , a second optical fiber 22 , and a third optical fiber 23 .

[0062] It should be noted that when the number of microneedles is one, the number of the first optical fiber 21, the second optical fiber 22 and the third optical fiber 23 can be combined in a reasonable manner, and the number can be the same or different. The optical fiber 20 can include a detection light incident optical fiber and an optical signal collection optical fiber, and is not limited to the several embodiments shown in the drawings.

[0063] See also Figure 3 In some embodiments, the number of microneedles 10 is one, the number of optical fibers 20 is one, and the optical fiber 20 is a third optical fiber 23. The first end of the third optical fiber 23 is used to receive the detection light separated by the optical splitter 14, so that the second end of the third optical fiber emits the detection light; the second end of the third optical fiber 23 is used to receive the optical signal so that the optical signal is emitted to the optical splitter 14 through the first end of the third optical fiber 23, so that the optical splitter 14 transmits the optical signal.

[0064] In this way, the intake of detection light and the reception of optical signals are completed through a single optical fiber 20, which can reduce the manufacturing cost of the collection device 100.

[0065] In some embodiments, when the third optical fiber 23 is provided, the number of the first optical fiber 21 and the second optical fiber 22 can be zero, one, two, two or more, respectively, and in various combinations. When the number of microneedles 10 is one and the third optical fiber 23 is not provided, at least one first optical fiber 21 and one second optical fiber 22 are provided in the collection device.

[0066] For example, the beam splitter 14 is an element that allows light of a specific wavelength to be incident, for example, a dichroic mirror 141 is used as the beam splitter 14. The dichroic mirror 141 is usually made of colorless calcite, and almost completely transmits light of certain wavelengths and almost completely reflects light of other wavelengths, so that the light source 300 can be separated into specific spectra, and when the detection light is incident at 45 degrees or a large angle, the light path direction of part of the spectrum is changed. The beam splitter 14 can be set to have an angle greater than 45 degrees with the detection light to separate the detection light and the collection light signal.

[0067] In one embodiment, the dichroic mirror 141 is disposed above the microneedle 10, and has an angle of 45 degrees with the detection light. The light emitted by the light source 300 passes through the beam splitter 14, and the infrared light with a wavelength of 2.5μm-16μm is separated and reflected to the end of the third optical fiber 23 away from the needle tip 12, and the light of other wavelengths is reflected to the side of the dichroic mirror 141 opposite to the third optical fiber 23, so that the infrared light is transmitted from the third optical fiber 23 to the needle tip 12 of the microneedle 10 as the detection light. The microneedle 10 penetrates the object 200 to be measured, and the detection light is emitted into the object 200 to be measured through the inside of the microneedle 10, and the glucose molecules in the object 200 to be measured are stimulated to emit Raman signal light. The Raman signal light is collected by the third optical fiber 23 and transmitted to the end of the third optical fiber 23 close to the dichroic mirror 141. The light signal is reflected by the dichroic mirror 141 and emitted along the optical path shown in the figure, so that the emission direction of the collected light signal is separated from the incident direction of the detection light.

[0068] Please refer to Figure 6-Figure 12 In some embodiments, the number of microneedles 10 is multiple, and the multiple microneedles 10 are arranged in parallel, and each microneedle 10 is correspondingly provided with an optical fiber 20.

[0069] In this way, the blood glucose meter 1000 can obtain multiple detection channels, which can reduce the signal-to-noise ratio, increase the intensity of the collected signal, and improve the quality of the collected signal.

[0070] For example, multiple microneedles 10 are arranged in parallel to form a microneedle array. In the microneedle array, the windows at the end of each microneedle 10 may be oriented in the same direction or in opposite directions, and the present application does not limit the orientation of the windows at the end of the microneedles 10. The arrangement of the microneedles 10 in a group of microneedle arrays may be uniform, with the same number of microneedles arranged per unit area, or may be uneven.

[0071] In the microneedle array, the number of optical fibers 20 disposed in each microneedle 10 can be multiple to enhance the intensity of the detection light and the collected signal. In the same microneedle array, the number of optical fibers 20 disposed in each microneedle 10 can be equal or unequal.

[0072] See also Figure 6-Figure 9 In some embodiments, there are multiple microneedles 10, and the optical fiber 20 corresponding to the microneedle 10 includes a first optical fiber 21 and a second optical fiber 22. The first optical fiber 21 is used to emit detection light, and the second optical fiber 22 is used to receive optical signals.

[0073] In some embodiments, each microneedle 10 is correspondingly provided with a first optical fiber 21 and a second optical fiber 22 .

[0074] In some embodiments, some of the microneedles 10 are correspondingly provided with the first optical fiber 21 , and some of the microneedles 10 are correspondingly provided with the second optical fiber 22 .

[0075] In some embodiments, a portion of the microneedles 10 are correspondingly provided with a first optical fiber 21 and a second optical fiber 22 .

[0076] In some embodiments, some of the microneedles 10 are correspondingly provided with the first optical fiber 21 and the second optical fiber 22 , and some of the microneedles 10 are correspondingly provided with the first optical fiber 21 , and some of the microneedles 10 are correspondingly provided with the second optical fiber 22 .

[0077] In this way, the paths for incident detection light and output of collected light signals are differentiated by the first optical fiber 21 and the second optical fiber 22, thereby reducing the possibility of interference with the collected light signals and avoiding reduction in the signal-to-noise ratio.

[0078] It can be understood that the above-mentioned part of the microneedles 10 is correspondingly provided with relevant optical fibers, which can be understood as each microneedle 10 in the part of the microneedles 10 has an optical fiber of a corresponding type. In the case where the number of microneedles 10 is multiple, the total number of optical fibers 20 is correspondingly set to multiple, and the number of optical fibers 20 in a single microneedle 10 can be zero, one, two, three, or more than three. Preferably, at least one optical fiber 20 is provided in each microneedle 10 in the microneedle array to avoid a reduction in the utilization rate of the collection device 100.

[0079] See also Figure 6 In the array shown, a first optical fiber 21 and a second optical fiber 22 are disposed in each microneedle 10 .

[0080] See also Figure 7 In the array shown, a first optical fiber 21 is disposed in some microneedles 10, and a second optical fiber 22 is disposed in some microneedles 10. The detection light is injected through the microneedles 10 provided with the first optical fiber 21. The excitation light signal of the glucose molecule is transmitted to the outside of the collection device 100 through the microneedles 10 provided with the second optical fiber 22.

[0081] See also Figure 8 In the array shown, a first optical fiber 21 and a second optical fiber 22 are correspondingly arranged in some microneedles 10, and the detection light can pass through this part of the microneedle 10, and the light signal can also be collected at the same time. The first optical fiber 21 is arranged in some microneedles 10, and only the incident detection light can pass through this part of the microneedle 10. The second optical fiber 22 is arranged in some microneedles 10, and this part of the microneedle 10 can only accommodate the light signal transmitted to the outside of the collection device.

[0082] The distribution of the first optical fiber 21 and the second optical fiber 22 in the microneedle array is not limited to the embodiment shown in the drawings, and the number of the first optical fiber 21 and the second optical fiber 22 corresponding to a single microneedle 10 can be combined and arranged in a reasonable manner. Fig. 9At least one first optical fiber 21 and at least one second optical fiber 22 are arranged in some microneedles 10 , a plurality of first optical fibers 21 are arranged in some microneedles 10 , and a plurality of second optical fibers 22 are arranged in some microneedles 10 .

[0083] Reference Figure 10-12 In some embodiments, there are multiple microneedles 10, and the optical fiber 20 corresponding to the microneedle 10 includes a third optical fiber 23. The first end of the third optical fiber 23 is used to receive the detection light separated by the optical splitter 14, so that the second end of the third optical fiber 23 emits the detection light; the second end of the third optical fiber 23 is used to receive the optical signal so that the optical signal is emitted to the optical splitter 14 through the first end of the third optical fiber 23, so that the optical splitter 14 transmits the optical signal. At least some of the microneedles are provided with at least one third optical fiber 23.

[0084] In this way, the cost of the collection device 100 can be reduced by providing the third optical fiber 23, so that the collection device 100 and the blood glucose meter 1000 of the present invention have a wider range of application scenarios.

[0085] In some embodiments, each microneedle 10 is provided with a third optical fiber 23 .

[0086] In some embodiments, at least a portion of the microneedles 10 are correspondingly provided with at least one third optical fiber 23 .

[0087] In some embodiments, some microneedles 10 are correspondingly provided with the first optical fiber 21 and the second optical fiber 22 , some microneedles are correspondingly provided with the first optical fiber 21 , some microneedles are correspondingly provided with the second optical fiber 22 , and some microneedles are correspondingly provided with the third optical fiber 23 .

[0088] In some embodiments, some microneedles 10 are provided with a first optical fiber 21 and a second optical fiber 22, and some microneedles 10 are provided with a third optical fiber 23.

[0089] In some embodiments, some microneedles 10 are correspondingly provided with the first optical fiber 21 , some microneedles are correspondingly provided with the second optical fiber 22 , and some microneedles are correspondingly provided with the third optical fiber 23 .

[0090] It is understandable that a microneedle in the above embodiment may have multiple types of optical fibers, or only one type, such as only the first optical fiber 21 or only the third optical fiber 23. Even in the case of multiple microneedles, some microneedles do not have optical fibers, which also falls within the scope of protection of the embodiments of the present application. The above-mentioned part of the microneedles 10 is correspondingly provided with relevant optical fibers, which can be understood as each microneedle 10 in the part of the microneedles 10 has an optical fiber of the corresponding type.

[0091] In some embodiments, please refer to Fig.10The number of microneedles 10 in the collection device 100 is multiple, and the multiple microneedles 10 are arranged in parallel to form an array. At least one third optical fiber 23 is arranged in each microneedle 10, and the third optical fibers 23 are arranged in parallel in a single microneedle 10. The beam splitter 14 is arranged above the array of microneedles 10, and has an angle of 45 degrees with the incident direction of the detection light.

[0092] In some embodiments, please refer to Fig.11 , some microneedles 20 are provided with a third optical fiber 23, some microneedles 20 are provided with a first optical fiber 21, and some microneedles 20 are provided with a second optical fiber 22. Preferably, a plurality of microneedles 20 provided with a third optical fiber 23 can be concentrated in the middle of the array. A plurality of microneedles 20 provided with a first optical fiber 21 can be concentrated on the left side of the collection device, and a light source (not shown) can be provided on the left side of the collection device. A plurality of microneedles 20 provided with a second optical fiber 22 can be concentrated on the right side of the collection device, that is, on the opposite side of the first optical fiber 21, so as to reduce the interference of the collection light signal with the detection light. The spectrometer can be provided above the third optical fiber 23.

[0093] In other embodiments, the first optical fiber 21 and the third optical fiber 23 for emitting the detection light and the second optical fiber 22 and the third optical fiber 23 for receiving the optical signal may also be arranged at intervals in the microneedle 20 array. In other embodiments, the first optical fiber 21 and the third optical fiber 23 for emitting the detection light and the second optical fiber 22 and the third optical fiber 23 for receiving the optical signal may also be irregularly dispersed at various positions in the microneedle 20 array.

[0094] In some embodiments, please refer to Fig.12 Some microneedles 20 are provided with a third optical fiber 23, some microneedles 20 are provided with a first optical fiber 21, some microneedles 20 are provided with a second optical fiber 22, some microneedles 20 are provided with a first optical fiber 21 and a second optical fiber 22, and some microneedles 20 are provided with a first optical fiber 21, a second optical fiber 22 and a third optical fiber 23.

[0095] When a plurality of microneedles 20 are provided in the collection device, at least one of the first optical fiber 21 or the third optical fiber 23 for emitting detection light and one of the second optical fiber 22 or the third optical fiber 23 for receiving optical signals are provided in the microneedle 20 array. Any number of the first optical fiber 21, the second optical fiber 22, and the third optical fiber 23 can be provided in a single microneedle 20 and combined in a reasonable manner.

[0096] The present application does not list all the implementation methods of combining the optical fiber 20 in different positions and quantities in the microneedle 20 array, but the collection device 100 of the first optical fiber 21, the second optical fiber 22, the third optical fiber 23 and the microneedle 20 having the above-mentioned characteristics and combined should be regarded as an embodiment of the present invention.

[0097] When there are multiple optical fibers 20 and second optical fibers 22 in the collection device 100 for receiving the collected optical signals, the optical signals received by each optical fiber 20 may be different. The optical signals collected by the multiple optical fibers 20 can reduce the interference of Rayleigh scattered light and non-glucose molecule excitation light through mathematical statistics methods, and eliminate bad collected signals. For example, the intensity of the optical signals received by the multiple optical fibers 20 is averaged, and the average value is used to evaluate the blood glucose concentration of the object 200 being measured.

[0098] In the collection device of the above embodiment, the microneedle 10 has a central hole 11. The central hole 11 is a hollow structure in the microneedle 10, which can accommodate the optical fiber 20 so that the detection light and the collection light signal can be transmitted.

[0099] See also Figure 1-Figure 12 In some embodiments, the optical fiber 20 partially extends into the central hole 11 , and the optical fiber 20 directly receives the light signal entering the microneedle 10 .

[0100] In this way, the optical fiber is closer to the point where the light signal is emitted, and it is easier to receive the light signal, which can improve the signal-to-noise ratio. For example, one end of the optical fiber 20 can be inserted into the vicinity of the needle head 12 at the end of the microneedle 10, and the optical fiber 20 can be arranged in parallel in the center hole 11. The number of optical fibers 20 extending into the center hole of the same microneedle 10 can be multiple, which can be multiple first optical fibers or multiple second optical fibers or multiple third optical fibers. The first optical fiber, the second optical fiber and the third optical fiber can be combined in pairs and extend into the same center hole, or the three can extend into one center hole at the same time. The number of optical fibers that can be accommodated in the center hole of a single microneedle can be limited by the ratio of the cross-sectional area of ​​the center hole to the cross-sectional area of ​​a single optical fiber.

[0101] See also Figure 13-Figure 16 In some embodiments, one end of the optical fiber 20 is at a predetermined distance from the needle tip 12 of the microneedle 10 , and the inner wall of the central hole 11 can reflect the optical signal to the optical fiber 20 .

[0102] In this way, the optical fiber 20 does not need to be inserted into the microneedle 10, and the microneedle 10 can be directly used as a transmission channel for the optical signal.

[0103] Specifically, the reflection and transmission of optical signals by the inner wall 13 does not have an obvious limitation on the number and function of the optical fibers 20. The end of the optical fiber 20 with a predetermined distance from the needle head 12 of the corresponding microneedle 10 can be fixed to the housing by bonding, tying, buckling, etc.

[0104] In some embodiments, see Fig.13, the number of microneedles 10 is one, and the total number of optical fibers 20 having a predetermined distance from the needle head 12 can be multiple, including a first optical fiber 21 and a second optical fiber 22. The first optical fiber 21 and the second optical fiber 22 each have one end disposed at the orifice 111, and have a predetermined distance from the needle head 12. The predetermined distance may be no greater than the distance between the orifice 111 and the needle head 12. The inner wall 13 of the microneedle 10 can reflect the detection light emitted by the first optical fiber 21 to the outside of the window at the needle head 12, and at the same time can reflect the collection light signal injected at the window to the port of the second optical fiber 22 located at the orifice 111. Fig.13 The non-solid arrow in indicates the direction of the optical path. The detection light is injected into the central hole 11 through the first optical fiber 21, and is injected into the object to be measured 200 through reflection from the inner wall 13 of the central hole 11, exciting the glucose molecules to generate optical signals. The excitation light signal generated by the glucose molecules is injected into the central hole 11 through the needle 12, and is transmitted to the second optical fiber 22 through reflection from the inner wall 13. The second optical fiber 22 collects the optical signal reflected by the inner wall 13 and transmits it to the outside of the collection device 100. The inner wall 13 can be polished to improve the reflectivity of the inner wall 13.

[0105] In some embodiments, please refer to Fig.15 , the number of microneedles 10 is one, and the total number of optical fibers 20 having a predetermined distance from the needle head 12 can be multiple, including a first optical fiber 21, a second optical fiber 22, and a third optical fiber 23. When the number of the third optical fiber 23 is zero, at least one first optical fiber 21 and one second optical fiber 22 are provided. When at least one third optical fiber 23 is provided, the number of the first optical fiber 21 and the second optical fiber 22 having a predetermined distance from the needle head 12 can be arbitrarily set within the volume of the collection device 100.

[0106] In some embodiments, see Fig.14 , the number of microneedles 10 is one, and the total number of optical fibers 20 having a predetermined distance from the needle head 12 may be one, including a third optical fiber 23. The third optical fiber 23 may be provided with an end located at an orifice 111 of the central hole 11, and the detection light is emitted into the central hole 11 through this end, and is reflected by the inner wall 13 and finally emitted into the object to be measured 200. The collection light signal is emitted into the central hole 11, reflected by the inner wall 112 and reaches the orifice 111, and is received by the third optical fiber 23.

[0107] In some embodiments, see Fig.16, the number of microneedles 10 is multiple, and the total number of corresponding optical fibers 20 is multiple. Among the multiple optical fibers 20, one end of some optical fibers 20 emitting detection light or receiving light signals has a predetermined distance from the needle head 12 of the corresponding microneedle 10, and some optical fibers 20 extend into the central hole 11, and one end emitting detection light or receiving light signals is close to the needle head 12. The optical fiber 20 having a predetermined distance from the needle head 12 can be provided with one end fixed at the orifice 111, and this part of the microneedle 10 refers to the reflection path of the above-mentioned light, and utilizes the reflection of the inner wall 13 to emit the detection light to the object to be measured 200 and collect the excitation light generated in the object to be measured 200. The optical fiber 20 extending into the central hole can emit the detection light or (and) receive the light signal through one end arranged near the needle head 12.

[0108] In some embodiments, a single microneedle 10 is provided with a plurality of optical fibers 20, some of the optical fibers 20 extend into the central hole 11, and one end of some of the optical fibers 20 is at a predetermined distance from the needle head 12. Fig.17 , Fig.17 It is an enlarged schematic diagram of a single microneedle 10. The third optical fiber 23 extends into the central hole 11, and one end of the emitting detection light and receiving light signal is close to the needle head 12. Part of the detection light can be emitted to the object 200 to be measured through the transmission of the third optical fiber 23, and part of the collection light signal is received by one end of the third optical fiber 23 located at the needle head 12 and transmitted to the other end of the third optical fiber 23. One end of the first optical fiber 21 and one end of the second optical fiber 22 are arranged at the orifice 111. Part of the detection light enters the central hole 11 through the transmission of the first optical fiber 21, and can finally be emitted into the object 200 to be measured after being reflected by the inner wall 13. Part of the collection light signal is reflected by the inner wall 13 to the orifice 111 of the central hole 11, and is received and transmitted by the second optical fiber 22.

[0109] See also Fig.18 In some embodiments, a light-focusing structure 15 is disposed at the needle tip 12 of the microneedle 10 , and the light-focusing structure 15 is used to focus the optical signal into the microneedle 10 .

[0110] In this way, by focusing the detection light and the collected light signal through the focusing structure 15, interference light can be reduced, the signal-to-noise ratio can be improved, and a higher quality collected light signal can be obtained.

[0111] In some embodiments, the focusing structure 15 can be composed of a plurality of small round beads 151, and the round beads 151 can be made of a material with good light reflectivity, for example, the focusing structure 15 can be made of glass or plastic. The focusing structure 15 can be surface polished to improve the light reflectivity and obtain a better focusing effect. The focusing structure 15 can be arranged inside the microneedle 10, fixedly connected to the closed port of the needle 12, and covering the entire inclined window of the needle. The focusing structure 15 can also be arranged on the inner wall 13 at the end of the microneedle 10, fixedly connected to the inner wall 13, and partially covering the window of the needle 12.

[0112] Please refer again Fig.17 In certain embodiments, the needle 12 of the microneedle 10 has a closed end 121 .

[0113] In this way, the possibility of mutual contamination between the collection device 100 and the object to be measured 200 can be reduced by the closed end 121 of the needle 12, thereby keeping the collection process clean.

[0114] Specifically, the closed end 121 of the needle 12 has good transmittance to the detection light and the collection light signal, but has a low reflectivity, so that the detection light and the collection light signal can be transmitted through the microneedle 10. The closed end 121 of the needle 12 can be made of the same material as the main part of the microneedle 10, for example, silicon, silicon dioxide or a biodegradable polymer with good biocompatibility. The closed end 121 can also be made of the same material as the focusing structure 15, so that the focusing structure 15 has better light focusing properties. The closed end 121 of the needle 12 can be integrally formed with the main part of the microneedle 10.

[0115] In some embodiments, the light focusing structure 15 is sealedly connected to the inner wall 13 of the microneedle 10 and can serve as a closed end 121 .

[0116] See also Figure 1 and Figure 6 In some embodiments, the collection device 100 further includes a housing 30 , and the microneedle 10 is fixed on the housing 30 .

[0117] In this way, the housing 30 can reduce the interference of the environment and the object 200 to the acquisition device 100 , and maintain stable contact between the acquisition device 100 and the object 200 .

[0118] Specifically, in the collection device 100, the microneedle 10 is fixed on the shell 30, which may be fixed by bonding with a biocompatible adhesive. When the collection device 100 is working, the shell 30 can be fixed on the surface of the object to be measured 200, shielding the collection device 100, while allowing the microneedle 10 to stably contact and detect the object to be measured 200. For example, by fixing the collection device 100 to the skin tissue of the upper arm of a human body through the shell 30, a stable and effective detection signal can be obtained while the human body is moving. The shell 30 can be made of a light-proof or light-poorly transparent material, such as plastic, alloy material, etc. An opening is set on the shell 30, and the microneedle 10 can protrude from the opening and penetrate into the object to be measured 200.

[0119] In certain embodiments, the detection light includes at least one of mid-infrared light and far-infrared light.

[0120] In this way, the specificity of glucose molecules in absorbing infrared light can be used to enhance the quality of the collected signal.

[0121] Specifically, infrared light can be divided into near infrared light, mid-infrared light and far infrared light according to its wavelength. The wavelength of near infrared light is 0.6μm-2.5μm, the wavelength of mid-infrared light is 2.5μm-16μm, and the wavelength range of far infrared light is greater than 16μm. Glucose molecules are specific in absorbing mid-infrared light and far-infrared light, and obviously absorb mid-infrared light and receive far-infrared light and emit strong spectral signals, thereby improving the signal-to-noise ratio. The light source 300 can be a single light source 300, and the detection light emitted is concentrated at a certain wavelength, for example, mid-infrared light with a wavelength of 2.5μm-16μm. The light source 300 can also be a mixed light source 300, which can emit detection lights of multiple different wavelengths.

[0122] See also Figure 1 The blood glucose meter 1000 of the embodiment of the present application includes a collection device 100 and a light source 300. The light source 300 is used to emit detection light and is connected to the collection device 100 through an optical fiber 20.

[0123] In some embodiments, the blood glucose meter 1000 further includes a processing device 400, and the processing device 400 is used to determine the blood glucose concentration of the object 200 to be measured according to the optical signal.

[0124] In this way, the blood glucose meter 1000 can convert the optical signal into readable blood glucose concentration data, which is conducive to the portability of the blood glucose detection device and improves the accuracy of blood glucose concentration detection.

[0125] Specifically, the processing device 400 may include a spectrometer 401 and a computer 402. The spectrometer 401 may be connected to the acquisition device 100 via the optical fiber 20, and is used to analyze the optical signal collected by the acquisition device 100, output the Raman spectrum, and transmit the spectrum data to the computer 402. The computer 402 receives the spectrum data transmitted by the spectrometer 401, and can convert the Raman spectrum into the blood glucose concentration by establishing a statistical model between the spectrum data and the blood glucose concentration, so as to facilitate reading. The transmission method between the spectrometer 401 and the computer 402 may be wireless transmission, for example, the spectrometer 401 transmits signals to the computer 402 via a Bluetooth connection.

[0126] In summary, in one embodiment, the human body is used as the object to be measured 200, the collection device 100 is fixed on the skin surface through the shell 30, the microneedle 10 is inserted into the subcutaneous tissue, and the needle 12 enters the superficial tissue under the skin, forming a tiny wound on the skin surface. The light source 200 emits a detection light in the mid-infrared band, and the detection light is emitted into the subcutaneous tissue through the optical fiber 20 through the inside of the microneedle 10, exciting the glucose molecules in the tissue to generate an excitation light signal. The light signal generated by the glucose molecule is received by the optical fiber 20 through the microneedle 10 and transmitted to the processing device 400. The processing device 400 converts the optical signal into an electrical signal, and analyzes the glucose molecule concentration information in the collection signal, so that the blood glucose meter 1000 can detect the blood glucose concentration of the human body.

[0127] It should be noted that the attached Figure 1-18 The structure shown belongs to a certain embodiment of the present invention. In other embodiments, multiple features of the present invention can be reasonably combined in other forms, and the combination shown in the drawings should not be used as a limitation on the implementation mode of the present application.

[0128] See also Fig.19 , the blood sugar detection method disclosed in the present application comprises:

[0129] S10, collecting the optical signal excited by the object 200 to be measured and received by the optical fiber 20, the optical signal is excited by the detection light, the detection light is emitted by the optical fiber 20 through the central hole 11 of the microneedle 10 to the object 200 to be measured, and the microneedle 10 is inserted into the object 200 to be measured;

[0130] S20, processing the optical signal to obtain blood glucose concentration.

[0131] See also Figure 1 Taking the detection of human blood glucose concentration as an example, the microneedle 10 is inserted into the subcutaneous tissue, and the first optical fiber 21 emits detection light to the subcutaneous tissue through the central hole 11 of the microneedle 10. The second optical fiber 22 collects Raman scattered light reflected by biological macromolecules including glucose in the subcutaneous tissue. The collected Raman scattered light is converted into glucose concentration data through the processing device 400, thereby obtaining the blood glucose concentration.

[0132] It should be noted that the present application does not limit the blood glucose meter 1000 and the blood glucose detection method to only use the Raman spectroscopy detection principle. Other detection methods such as photoacoustic spectroscopy, fluorescence, polarization rotation, near-infrared spectroscopy and mid-infrared spectroscopy can be used as detection means, combined with the collection device 100 described in the present application to achieve blood glucose detection.

[0133] The acquisition device 100, blood glucose meter 1000 and blood glucose detection method disclosed in the present application can avoid the attenuation of the detection light intensity on the surface of the object 200 to be measured, improve the signal-to-noise ratio of the acquisition signal, especially avoid the attenuation of mid- and far-infrared light, and improve the specificity of the detection light in detecting glucose molecules. At the same time, the acquisition device 100 can be fixed on the surface of the skin to reduce human body disturbance and external interference, and increase the stability of the detection. In addition, compared with the relevant technology, the detection device and method of the present application do not need to consume biological enzymes, which reduces the user's use cost and enhances practicality and convenience.

[0134] In the description of this specification, the description with reference to the terms "one embodiment", "certain embodiments", "illustrative embodiments", "examples", "specific examples", or "some examples" means that the specific features, structures, materials, or characteristics described in conjunction with the embodiments or examples are included in at least one embodiment or example of the present application. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described may be combined in any one or more embodiments or examples in a suitable manner.

[0135] Although the embodiments of the present application have been shown and described, those skilled in the art will appreciate that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present application, and that the scope of the present application is defined by the claims and their equivalents.

Claims

1. A collection device for a blood glucose meter, characterized in that: The collection device comprises: A microneedle, wherein the microneedle is used to pierce the object to be tested; An optical fiber, one end face of which faces toward or is located inside the microneedle, and the optical fiber is used to emit detection light to the object to be measured through the needle tip of the microneedle, and is used to receive light signals excited by the object to be measured through the needle tip of the microneedle.

2. The collection device according to claim 1, characterized in that: The number of the microneedle is one, and the microneedle should be provided with at least one optical fiber.

3. The collection device according to claim 2, characterized in that: When the total number of the optical fibers is multiple, the optical fibers include a first optical fiber and a second optical fiber, the first optical fiber is used to emit the detection light, and the second optical fiber is used to receive the optical signal; and / or, When the total number of the optical fibers is plural, the optical fibers include a third optical fiber, and the third optical fiber is used to emit the detection light and receive the optical signal.

4. The collection device according to claim 2, characterized in that: When the number of the optical fiber is one, the optical fiber is a third optical fiber, and the first end of the third optical fiber is used to receive the detection light separated by the splitter, so that the second end of the third optical fiber emits the detection light; the second end of the third optical fiber is used to receive the optical signal so that the optical signal is emitted to the splitter through the first end of the third optical fiber, so that the splitter transmits the optical signal.

5. The collection device according to claim 1, characterized in that: When there are multiple microneedles, the multiple microneedles are arranged in parallel, and some or all of the microneedles are correspondingly provided with the optical fiber.

6. The collection device according to claim 1 or 5, characterized in that: The optical fiber corresponding to the microneedle includes: one or more of a first optical fiber, a second optical fiber and a third optical fiber; when the number of the microneedles is multiple, the optical fibers corresponding to each microneedle are the same or different; wherein the first optical fiber is used to emit the detection light, the second optical fiber is used to receive the optical signal, the first end of the third optical fiber is used to receive the detection light separated by a spectrometer, so that the second end of the third optical fiber emits the detection light; the second end of the third optical fiber is used to receive the optical signal so that the optical signal is emitted to the spectrometer through the first end of the third optical fiber, so that the spectrometer transmits the optical signal.

7. The collection device according to claim 6, characterized in that: Each of the microneedles is correspondingly provided with the first optical fiber and the second optical fiber; or, Some of the microneedles should be provided with the first optical fiber, and some of the microneedles should be provided with the second optical fiber; or, Some of the microneedles are correspondingly provided with the first optical fiber and the second optical fiber; or, Some of the microneedles should be provided with the first optical fiber and the second optical fiber, some of the microneedles should be provided with the first optical fiber, and some of the microneedles should be provided with the second optical fiber; or, Each of the microneedles is provided with a third optical fiber; or, At least some of the micro-needles are correspondingly provided with at least one third optical fiber; or, Some of the microneedles should be provided with the first optical fiber and the second optical fiber, some of the microneedles should be provided with the first optical fiber, some of the microneedles should be provided with the second optical fiber, and some of the microneedles should be provided with the third optical fiber; or, Some of the microneedles should be provided with the first optical fiber and the second optical fiber, and some of the microneedles should be provided with the third optical fiber; or, Some of the microneedle pairs should be provided with the first optical fiber, some of the microneedle pairs should be provided with the second optical fiber, and some of the microneedle pairs should be provided with the third optical fiber.

8. The collection device according to any one of claims 1 to 6, characterized in that: The microneedle has a central hole, the optical fiber partially extends into the central hole, and the optical fiber directly receives the optical signal entering the microneedle; and / or, One end of the optical fiber is at a predetermined distance from the needle tip of the microneedle, and the inner wall of the central hole can reflect the optical signal to the optical fiber.

9. The collection device according to claim 1, characterized in that: A light-gathering structure is provided at the needle tip of the microneedle, and the light-gathering structure is used to converge the light signal into the microneedle.

10. The collection device according to claim 1, characterized in that: The needle tip of the microneedle has a closed end.

11. The collection device according to claim 1, characterized in that: The collection device also includes a shell, and the microneedle is fixed on the shell.

12. The collection device according to claim 1, characterized in that: The detection light includes at least one of mid-infrared light and far-infrared light.

13. A blood glucose meter, characterized in that: include: The collection device according to any one of claims 1 to 12; and A light source is used to generate the detection light.

14. The blood glucose meter according to claim 13, characterized in that: The blood glucose meter further comprises a processing device, and the processing device is used to determine the blood glucose concentration of the measured object according to the optical signal.

15. A blood sugar detection method, characterized in that: include: Collecting an optical signal excited by the object to be measured and received by the optical fiber, wherein the optical signal is excited by a detection light, wherein the detection light is emitted by the optical fiber through the central hole of the microneedle toward the object to be measured, and the microneedle is inserted into the object to be measured; The optical signal is processed to obtain blood glucose concentration.

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