Composition for promoting transdermal permeation of caffeine and application thereof

Abstract

The invention discloses a composition for promoting transdermal permeation of caffeine and application of the composition, and belongs to the technical field of cosmetic preparation. The composition is prepared from the following components in parts by weight: 1 to 5 parts of pentanediol, 1 to 3 parts of isosorbide dimethyl ether, 0.5 to 3 parts of soybean seed extract, 0.01 to 0.1 part of tetrahydropiperine, 0.4 to 4 parts of glycosylglycerol / glycerol and 0.1 to 1 part of papain. According to the composition for promoting percutaneous penetration of caffeine, starting from a plurality of dimensions in design thoughts and penetration promotion channels, all the components are matched and synergistically used according to a specific proportion, percutaneous absorption of active ingredients can be promoted to the maximum extent, especially percutaneous penetration of caffeine can be effectively promoted, and when the composition is applied to actual products, the effect of promoting percutaneous penetration of caffeine is achieved. The compound not only has a permeation enhancing effect on a single caffeine component, but also has an obvious synergistic effect on the whole functional composition.

Description

Technical Field

[0001] The invention relates to the technical field of cosmetic preparation, in particular to a composition for promoting the transdermal penetration of caffeine and application thereof. Background Art

[0002] With the development of the cosmetics industry, consumers are paying more and more attention to the efficacy and safety of cosmetics, and are increasingly favoring natural, green and organic cosmetics. This has prompted cosmetics companies to pay more and more attention to the efficacy of products, the selection of raw materials and environmental issues in the production process when developing products. The efficacy of cosmetics depends on the penetration ability of active ingredients. The main pathways for the penetration of active ingredients are the stratum corneum, hair follicles and sweat ducts. The latter two pathways are often called "bypasses" because the skin appendages account for less than 1% of the entire skin surface area, so in most cases they are not the main absorption pathways. There are two pathways for percutaneous absorption through the stratum corneum, namely diffusion through the lipid bilayer in the gap between keratinocytes and diffusion through the densely cross-linked protein network structure on the stratum corneum cell membrane. If the stratum corneum is too thick or too dense, the active ingredients will have difficulty penetrating into the deep tissues of the skin and will not be able to exert their effects.

[0003] Caffeine is a xanthine alkaloid compound, mainly found in plants such as coffee trees and tea trees. It is one of the most widely used functional raw materials and is widely used in fat loss, anti-oxidation, reducing dark circles, promoting microcirculation, and promoting hair growth. However, caffeine has certain irritation and dehydration properties. During use, it is necessary to avoid skin sensitivity and dryness to avoid adverse reactions. In addition, due to the particularity of its raw materials, caffeine is cytotoxic at high usage levels, and the raw material has a low solubility in water. It is not suitable to be added in large quantities in cosmetics, and its bioavailability to the skin is also relatively low.

[0004] Chinese patent document CN 115414298A discloses a penetration-enhancing composition, a preparation method and application thereof, comprising 50-80% sea fennel fermentation liquid, 2-5% wild soybean seed extract, 5-20% oil and 0.2-0.5% thickener, for promoting the percutaneous permeation and absorption of active substances, especially polyphenol compounds. The composition achieves the penetration-enhancing effect through hydration, similar solubility and structural change; Chinese patent document CN 112245366B discloses a penetration-promoting composition containing hyaluronic acid, comprising 2-5 parts of hyaluronic acid, 1-3 parts of bis-diethoxydiglycol cyclohexane 1,4-dicarboxylate, and 8-15 parts of polyols. The composition mainly achieves the effects of moisturizing and locking water by adding hyaluronic acid of different molecular weights, and bis-diethoxydiglycol cyclohexane 1,4-dicarboxylate temporarily changes the structure of the stratum corneum, allowing water-soluble components to enter the skin, thereby improving the penetration effect of water-soluble components on the stratum corneum. Chinese patent document CN113332187A discloses a penetration-promoting composition containing hot spring water. The composition and its application include the following components: hot spring water, propylene glycol, PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerol, bifid yeast fermentation product lysate and piperine, wherein piperine, hot spring water, bifid yeast fermentation product lysate can increase the diffusion rate of the functional ingredients in the skin, PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerol and polyol can increase the distribution of the functional ingredients to the skin, and the compounding of these components makes the components work synergistically, avoiding the problem that a single penetration-promoting pathway cannot balance the penetration-promoting effect and is easy to cause irritation due to the amount used. At present, no prior art has been found to disclose a composition that has a penetration-promoting effect on caffeine, so the development of a composition that promotes the permeation of caffeine through the skin is of great significance for improving the bioavailability of caffeine to the skin and reducing toxic and side effects. Summary of the invention

[0005] In view of the problems existing in the prior art, the present invention provides a composition for promoting the transdermal penetration of caffeine, which can promote the transdermal penetration rate of caffeine, reduce the concentration of caffeine used alone, thereby reducing the toxic and side effects of caffeine used alone, and also have a good moisturizing effect on the skin.

[0006] The technical solution of the present invention is:

[0007] A composition for promoting transdermal penetration of caffeine comprises pentylene glycol, dimethyl isosorbide, soybean seed extract, tetrahydropiperine, glyceryl glucoside / glycerol and papain.

[0008] Furthermore, the composition for promoting transdermal penetration of caffeine includes, by weight, 1-5 parts of pentylene glycol, 1-3 parts of dimethyl isosorbide, 0.5-3 parts of soybean seed extract, 0.01-0.1 parts of tetrahydropiperine, 0.4-4 parts of glycerol glucoside / glycerol, and 0.1-1 parts of papain.

[0009] Furthermore, the mass ratio of pentanediol, glycerol glucoside / glycerol and papain is (1-5): (0.5-3): (0.1-1).

[0010] Furthermore, the mass ratio of dimethyl isosorbide, soybean seed extract and tetrahydropiperine is (1-3): (0.5-3): (0.01-0.1).

[0011] Furthermore, the mass ratio of pentylene glycol, dimethyl isosorbide, soybean seed extract, tetrahydropiperine, glyceryl glucoside / glycerol and papain is 5:2:1.5:0.05:2:0.5.

[0012] Furthermore, the weight ratio of glycerol glucoside / glycerol to papain is 4:1.

[0013] The invention also provides application of the composition for promoting the percutaneous penetration of caffeine in cosmetics.

[0014] A cosmetic containing a composition for promoting transdermal penetration of caffeine includes lotions, creams, essences and masks.

[0015] A basic aqueous cosmetic comprises a phase A and a phase B, wherein the phase A comprises 4 parts of caffeine, 2 parts of glycerol, 0.5 parts of hexylene glycol, 0.5 parts of cinnamaldehyde, 0.2 parts of xanthan gum and 77.7-89.69 parts of water, and the phase B comprises 1-5 parts of pentylene glycol, 1-3 parts of dimethyl isosorbide, 0.5-3 parts of soybean seed extract, 0.01-0.1 parts of tetrahydropiperine, 0.5-3 parts of glyceryl glucoside / glycerol and 0.1-1 parts of papain.

[0016] A method for preparing a basic aqueous cosmetic comprises the following steps:

[0017] S1. Accurately weigh each raw material component according to the ratio;

[0018] S2, heat the raw material of phase A to 75-80°C, stir and dissolve;

[0019] S3. Cool down to 40°C, premix the raw materials of phase B and add them into phase A, stir evenly to obtain basic water-based cosmetics.

[0020] In the technical solution of the present invention, the pentylene glycol is derived from green and environmentally friendly sugarcane bagasse, is easily biodegradable, has high safety in use, is a good moisturizer and solvent in cosmetics, and can effectively increase the water content of the skin. Due to its own characteristics, caffeine has a low solubility in water, and the use of pentylene glycol can also play a good solubilizing effect, making the product system more stable; and pentylene glycol can also enhance the bioavailability of active substances and effectively improve the efficacy of active substances; the glycerol glucoside / glycerol can promote the synthesis of aquaporin-3 in skin cells. This protein is used to transport water and glycerol, and can selectively import or export water molecules into or out of cells, produce water channels in skin cells, and enable the skin to achieve self-generation of water from endogenous sources and provide itself with the required water; at the same time, it can promote the gene expression of filaggrin. In the upper epidermal stratum corneum, filaggrin is further processed into amino acids, which helps the skin retain moisture; in addition, glycerol glucoside has good anti-inflammatory effects, and can effectively reduce the expression of pro-inflammatory cytokines such as TNFα, IL-6, IL-1β, SCF, etc., repair the barrier, and help damaged skin cells recover health;

[0021] In the present invention, the pentylene glycol and glyceryl glucoside / glycerol act synergistically from different pathways to effectively increase the water content in the stratum corneum of the skin. The two increase the hydration force of nitrogen-containing substances in the keratin of stratum corneum cells, causing the cells themselves to swell and reduce the density of the structure, thereby increasing the permeability of the active substance, that is, promoting the transdermal absorption of caffeine. At the same time, glyceryl glucoside / glycerol has a repairing effect on damaged skin cells, can help damaged skin recover and better absorb active substances;

[0022] The papain is a natural fruit extract from papaya, has three disulfide bridges and one thiol group, and is a single-chain polypeptide. It has a hydrolytic effect on the stratum corneum, can promote the decomposition of thick and aged stratum corneum cells, accelerate metabolism, make keratin cells loose and promote the absorption of active ingredients;

[0023] The isosorbide dimethyl ether has an oily liquid appearance and can be dissolved in water in any proportion. It can also be well dissolved in other polyols and esters. It can well enhance the transport capacity of water-soluble or oil-soluble active ingredients, improve their solubility in the skin, and thus reduce the driving force of penetration. The same penetration rate can be achieved with a lower dosage. Its mechanism is mainly to dissolve the free fat in the skin and temporarily change the skin structure, thereby promoting the active ingredients to pass through the skin membrane and penetrate into the epidermis, giving full play to the effect of the active components.

[0024] The soybean seed extract is a kind of lysolecithin derived from soybean seeds, which belongs to enzymatic phospholipids. It is formed after a phospholipid molecule is hydrolyzed to remove a fat chain under enzyme catalysis. The structure of the enzymatic phospholipid is similar to the bilayer structure of the phospholipids in skin cells. The single fatty acid chain contained in it can interact with the intercellular lipids, and the unsaturated phosphatidyl group contained in it can reversibly disrupt the intercellular lipid chains. In addition, the soybean seed extract has a special conical molecular structure, which can act as an edge activator to pass through the epidermis, help the active substance molecules to penetrate into the intercellular molecular gaps, and thus promote the penetration and absorption of the active substance.

[0025] The tetrahydropiperine is a lipophilic penetration-promoting ingredient derived from black pepper and soluble in polyols and oils. The two main pathways of transdermal absorption are diffusion through the lipid bilayer in the interstitial space of keratinocytes and diffusion through the densely cross-linked protein network structure on the stratum corneum cell membrane. The tetrahydropiperine acts on the two pathways simultaneously, increasing the fluidity of the lipid bilayer and opening the tight junction proteins of the cells, thereby promoting the absorption of the active ingredients by the skin.

[0026] In the technical scheme of the present invention, the isosorbide dimethyl ether, soybean seed extract and tetrahydropiperine work synergistically in a mass ratio of (1-3): (0.5-3): (0.01-0.1), which can temporarily destroy the structure of lipids in the stratum corneum, change the orderly stacked skin flat keratinocytes, reduce the orderliness of lipid arrangement, and make lipids completely fluidized, thereby promoting the smooth passage of effective ingredients; and tetrahydropiperine can also open the tight junction protein of the keratinocyte membrane, so that different transdermal absorption pathways can be taken into account; in addition, the above-mentioned isosorbide dimethyl ether and tetrahydropiperine are both lipophilic components, and the soybean seed extract has a structure similar to the phospholipid bilayer of skin cells. According to the theory of like dissolves like, when an external substance has a composition, structure and properties similar to those of the skin, it is easy to penetrate the skin. Therefore, the three substances work synergistically, whether it is water-soluble or oil-soluble active ingredients, it can well improve its diffusion ability and promote the transdermal rate of the active ingredients.

[0027] The composition for promoting the transdermal penetration of caffeine provided by the present invention has obvious effects and clear mechanisms. The pentylene glycol and glycerol glucoside / glycerol act synergistically from different pathways, which can effectively increase the water content in the stratum corneum of the skin; according to the hydration theory of the skin, in the keratin of the stratum corneum cells, when the hydration force of nitrogen-containing substances increases, the cells themselves will swell, thereby reducing the density of the structure and increasing the permeability of the active substance; when dimethyl isosorbide, soybean seed extract and tetrahydropiperine act synergistically in a specific ratio of (1-3): (0.5-3): (0.01-0.1), they can temporarily and reversibly change the lipid structure between the stratum corneum of the skin and the density of the tight junction proteins on the keratinocyte membrane, thereby promoting the active substances with different diffusion pathways to better penetrate into the dermis of the skin and exert their effects, because dimethyl isosorbide and When used in combination with tetrahydropiperine, it has both hydrophilic and lipophilic properties, and can enhance the transport capacity of different types of active substances. Soybean seed extract contains a structure similar to the phospholipid bilayer of skin cells. According to the theory of like dissolves like, when external substances have similar components, structures and properties as the skin, active ingredients are more likely to penetrate the stratum corneum and provide nutrients to the skin; finally, the glyceryl glucoside / glycerol can repair damaged skin cells and restore the skin's normal and healthy barrier function; the papain can promote the decomposition of aged stratum corneum cells, accelerate metabolism, and make keratinocytes loose and easier to absorb nutrients; the combination of the two can make the skin stratum corneum reach a better state, which is conducive to enhancing the absorption of active ingredients.

[0028] Compared with the prior art, the present invention has the following beneficial effects:

[0029] 1. The present invention provides a composition for promoting the transdermal penetration of caffeine. The compounding of these components enables the components to work synergistically. From multiple pathways, caffeine can achieve the same transdermal penetration rate at a relatively low addition amount, and can also have a significant improvement effect when the amount of caffeine added to the product is reduced.

[0030] 2. The components of the composition for promoting the transdermal penetration of caffeine of the present invention are matched in a specific ratio and used synergistically. The mechanism is considered from multiple aspects, taking into account hydration, similar solubility and structural change. It can promote the penetration of active substances with different hydrophilic and lipophilic properties and active substances with different diffusion pathways. Combined with the optimization of the health state of the skin stratum corneum, the transdermal absorption of the active ingredients is promoted to the greatest extent.

[0031] 3. The composition for promoting the transdermal penetration of caffeine provided by the present invention not only has a penetration-promoting effect on a single caffeine component, but also has an obvious synergistic effect on the entire functional composition, and also has a certain penetration-promoting and synergistic effect on other functional active ingredients. It can be widely used in various functional products, including essence water, lotions, creams, essences, facial masks, etc., and has a wide range of uses. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 Periocular photographs were collected for VISIA-CR of subject 1, with the left side showing the pre-test photograph and the right side showing the post-test photograph;

[0033] Figure 2 Periocular photographs were collected for VISIA-CR of subject 2, with the left side showing the pre-test photograph and the right side showing the post-test photograph;

[0034] Figure 3 Periocular photographs collected for VISIA-CR of subject 3, with the left side showing the pre-test photograph and the right side showing the post-test photograph. DETAILED DESCRIPTION

[0035] The experimental methods in the following examples of the present invention, where no specific conditions are specified, are usually carried out under conventional conditions or under conditions recommended by the manufacturers. The various commonly used chemical reagents used in the examples are all commercially available products.

[0036] In order to make the purpose, technical scheme and advantages of the present invention clearer, the present invention is further described in detail below in conjunction with specific embodiments. It should be understood that these descriptions are exemplary only and are not intended to limit the scope of the present invention. In addition, in the following description, the description of known structures and technologies is omitted to avoid unnecessary confusion of the concept of the present invention.

[0037] In the following examples and comparative examples, reagents not otherwise specified are conventional reagents and can be purchased from conventional reagent production and sales companies. Information on some raw material manufacturers is shown in Table 1:

[0038]

[0039] Examples 1-3

[0040] Examples of basic water-based products containing a composition for promoting transdermal penetration of caffeine. The specific formula of each example is shown in Table 2. The preparation method of the basic water-based products in each example is the same, comprising the following steps:

[0041] S1. Accurately weigh the raw material ingredients according to the ratio;

[0042] S2, heat the raw material of phase A to 75-80°C, stir and dissolve;

[0043] S3. Cool down to 40°C, premix the raw materials of phase B and add them into phase A, and stir evenly.

[0044] The difference between Comparative Examples 1-8 and the reference examples and Examples 1-3 is that the formulas of the products are different, wherein Comparative Examples 1-6 lack a certain component in the composition for promoting transdermal penetration of caffeine (Phase B), Comparative Example 7 is that the weight ratio of pentylene glycol, dimethyl isosorbide, soybean seed extract, tetrahydropiperine, glycerol glucoside / glycerol and papain is not 5:2:1.5:0.05:2:0.5, and Comparative Example 8 is that the weight ratio of dimethyl isosorbide, soybean seed extract and tetrahydropiperine is not (1-3): (0.5-3): (0.01-0.1); the control example lacks a penetration-enhancing composition; the specific formula is shown in Table 2.

[0045] Table 2, Examples 1-3 and Comparative Examples 1-8, Basic Water-Based Product Formula Table of Reference Examples (parts by weight)

[0046]

[0047] Test Example 1: Investigation of the effect of the composition for promoting caffeine transdermal permeation on the caffeine transdermal permeation rate

[0048] 1. Test samples: basic water-based products prepared in Examples 1-3 and Comparative Examples 1-8 and Control Examples.

[0049] 2. Test method: Select fresh abdominal or back skin of one-month-old male Bama Xiang pigs, and use Franz vertical diffusion cell (TP-6 transdermal diffusion instrument of Jingtuo Instrument) to conduct transdermal experiment. Fix the pig skin in the middle of two diffusion cells, the receiving liquid is freshly prepared physiological saline, the test liquid is the basic water-type product of Examples 1 to 3 and Comparative Examples 1 to 8 and the control example, three parallel samples are provided for each group, and the transdermal test is conducted in a 37°C circulating water bath and 400r.pm magnetic stirring. Take 2ml of sample at 2h, 4h, 8h, and 24h after the start of the test, and add 2ml of physiological saline after sampling; after the sample is diluted and filtered with a 0.22μm filter membrane, the caffeine content is determined by high performance liquid chromatography, and the transdermal rate and recovery rate of caffeine in the sample are calculated. The theoretical value of caffeine recovery rate is generally 100±10%, which can verify the validity of this experiment;

[0050] Content determination method: The content of caffeine was determined by high performance liquid chromatography, and the chromatographic conditions were as follows: the chromatographic column was ZORBAX SB-C18 chromatographic column (4.6x 250mm 5-Micron); the mobile phase was methanol: water = 30:70; the flow rate was 1ml / min, the detection wavelength was 273nm, the column temperature was 40℃, and the injection volume was 20ul;

[0051] Active substance cumulative permeability or retention rate (%) calculation formula:

[0052] Cumulative skin penetration rate (%) = total amount of permeation in the receiving solution / total amount of the test solution in the diffusion cell*100%.

[0053] 3. Test results:

[0054] Table 3. Caffeine permeation rate results

[0055]

[0056]

[0057] As shown in Table 3, the average caffeine permeability of the compositions of Examples 1-3 of the present invention is higher than that of Comparative Examples 1-8, and the average caffeine recovery rate is 100±10%, indicating that the composition of the present invention can promote the percutaneous permeation of caffeine, among which Example 2 has the highest permeability, which is the best embodiment of the present invention; while the percutaneous permeability of Comparative Examples 1-6 decreases after any component in the composition is missing, and the ratio of the components in Comparative Examples 7-8 changes, resulting in a significant decrease in the percutaneous permeability, indicating that the components in the permeation-enhancing composition of the present invention act synergistically and complement each other to exert a better permeation-enhancing effect.

[0058] Test Example 2: Human test effect of the composition for promoting transdermal penetration of caffeine in a product for removing dark circles

[0059] 1. Test sample: 2 parts of caffeine, 2 parts of niacinamide, and 0.5 parts of glucosyl hesperidin are used as the functional composition, and an emulsifier, oil, thickener, moisturizer, preservative, etc. are added to prepare an eye cream, and then the caffeine transdermal penetration promoting composition (phase B) of Examples 1-3, Comparative Examples 1-8 and the reference example are premixed and added to prepare a test sample;

[0060] 2. Test population: 96 people with obvious dark circles were selected and divided into 12 groups, with 8 people in each group.

[0061] 3. Test area: around eyes.

[0062] 4. Test conditions: The test environment temperature is 20-22℃, the humidity is 40-60%, and real-time dynamic monitoring is carried out. Before each test, you need to wash your face and sit in a constant temperature and humidity room for 15 minutes before testing.

[0063] 5. Testing instruments: Skin melanin tester MPA580, skin analysis tester VISIA-CR.

[0064] 6. Test method: Apply an appropriate amount of the product to the eye area once in the morning and evening every day for 4 consecutive weeks. Test the skin melanin value before and after the test, take photos and analyze them with VISIA, and fill out the questionnaire after the test.

[0065] 7. Test indicators and principles:

[0066] 1) Skin melanin value. The testing principle of the skin melanin probe is based on the absorption principle of the spectrum. The test probe emits three specific wavelengths of light, and the receiver receives the reflected light. The position of the light transmitter and receiver in the probe ensures that only diffuse light and scattered light can be tested. Because the amount of emitted light is certain, the amount of reflected light after the test light is irradiated on the human skin is used to determine the melanin content in the skin and calculate the change rate. The change rate = (melanin value after the test - melanin value before the test) / melanin value before the test;

[0067] 2) Questionnaire survey on dark circles around eyes and self-assessment: Three subjects who used the eye cream of the composition of Example 2 were randomly selected, and pictures of the subjects' eye circles before and after using the product were collected by VISIA-CR before and after one month of use to compare and evaluate the changes in dark circles;

[0068] 3) Self-evaluation test: Before use and 4 weeks after using the sample, self-check the skin condition and the degree of change of dark circles, and fill in the questionnaire. Use the scoring method for evaluation: 10 points means very good effect, 6 points means average effect, 1 point means no obvious effect, and record the evaluation results.

[0069] 8. Calculation and analysis of results:

[0070] The experimental results of the periocular melanin value before and after the test are shown in Table 4:

[0071] Table 4. Test results of periorbital melanin value

[0072]

[0073]

[0074] The self-assessment test results of the volunteers before and after the test are shown in Table 5:

[0075] Table 5. Volunteer self-assessment test results

[0076]

[0077] According to the test results in Table 4 and Table 5, when the compositions for promoting transdermal penetration of caffeine provided in Examples 1-3 of the present invention are added to the dark circle removal product according to the component ratios in the examples, they can more effectively improve the melanin deposition of the skin around the eyes compared to the control group, and the dark circle removal effect is more obvious. This shows that the compositions for promoting transdermal penetration of caffeine of the present invention not only have a penetration-promoting effect on a single caffeine component, but also have a penetration-promoting effect on active substances with different hydrophilic and lipophilic properties and active substances with different diffusion pathways. It has a significant synergistic effect on the entire functional composition and can promote the transdermal absorption of active ingredients to the greatest extent. Among them, Example 2 has the best improvement effect and is the best embodiment of the present invention. Figure 1-3 It can be seen that the dark circles of the three subjects were significantly improved after using the eye cream containing the composition of Example 2. The results of Comparative Examples 1-8 show that the dark circle removal effect of the composition that lacks any effective ingredient of the composition that promotes the transdermal penetration of caffeine or changes the ratio of the components of the composition that promotes the transdermal penetration of caffeine is worse than that of Example 2, but still has an improved trend compared with the blank control example, indicating that the composition that promotes the transdermal penetration of caffeine of the present invention is a composition that promotes the transdermal penetration of caffeine with components in a specific ratio and synergistic use to maximize the transdermal absorption of the active ingredient.

[0078] The above-mentioned embodiments only express several implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A composition for promoting the percutaneous penetration of caffeine, characterized in that: include: Pentylene glycol, dimethyl isosorbide, soja seed extract, tetrahydropiperine, glyceryl glucoside / glycerin and papain.

2. The composition for promoting caffeine permeation through the skin according to claim 1, characterized in that: By weight, the invention comprises 1-5 parts of pentylene glycol, 1-3 parts of dimethyl isosorbide, 0.5-3 parts of soybean seed extract, 0.01-0.1 parts of tetrahydropiperine, 0.4-4 parts of glycerol glucoside / glycerol and 0.1-1 parts of papain.

3. The composition for promoting caffeine permeation through skin according to claim 1, characterized in that: The mass ratio of pentanediol, glycerol glucoside / glycerol and papain is (1-5): (0.5-3): (0.1-1).

4. The composition for promoting caffeine permeation through skin according to claim 1, characterized in that: The mass ratio of isosorbide dimethyl ether, soybean seed extract and tetrahydropiperine is (1-3): (0.5-3): (0.01-0.1).

5. The composition for promoting caffeine permeation through skin according to claim 1, characterized in that: The mass ratio of pentylene glycol, dimethyl isosorbide, soybean seed extract, tetrahydropiperine, glycerol glucoside / glycerol and papain is 5:2:1.5:0.05:2:0.

5.

6. The composition for promoting caffeine permeation through skin according to claim 1, characterized in that: The weight ratio of the glycerol glucoside / glycerol to papain is 4:

1.

7. Use of the composition for promoting transdermal penetration of caffeine as claimed in any one of claims 1 to 6 in cosmetics.

8. A cosmetic according to claim 7, characterized in that: Including lotions, creams, serums and masks.

9. A basic aqueous cosmetic, characterized in that: The invention comprises a phase A and a phase B, wherein the phase A comprises 4 parts of caffeine, 2 parts of glycerol, 0.5 parts of hexylene glycol, 0.5 parts of cinnamaldehyde, 0.2 parts of xanthan gum and 77.7-89.69 parts of water, and the phase B comprises 1-5 parts of pentylene glycol, 1-3 parts of dimethyl isosorbide, 0.5-3 parts of soybean seed extract, 0.01-0.1 parts of tetrahydropiperine, 0.5-3 parts of glyceryl glucoside / glycerol and 0.1-1 parts of papain.

10. A method for preparing the basic aqueous cosmetic according to claim 9, characterized in that: The steps include: S1. Accurately weigh each raw material component according to the ratio; S2, heat the raw material of phase A to 75-80°C, stir and dissolve; S3. Cool down to 40°C, premix the raw materials of phase B and add them into phase A, stir evenly to obtain basic water-based cosmetics.

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