NAD < + > composition for skin anti-aging and firming cosmetics and preparation process of NAD < + > composition

Abstract

The invention provides an NAD < + > composition for skin anti-aging and firming cosmetics and a preparation process of the NAD < + > composition. The NAD + composition is prepared from the following components in parts by weight: 40 to 50 parts of dipropylene glycol, 0.1 to 1 part of nicotinamide, 0.001 to 0.01 part of nicotinamide adenine dinucleotide, 0.05 to 0.1 part of beta-nicotinamide mononucleotide, 0.1 to 0.5 part of leontopodium alpinum flower / leaf extract, 0.1 to 0.5 part of leontopodium alpinum callus extract, 0.1 to 0.5 part of leontopodium alpinum yeast fermentation lysate filtrate and 0.1 to 0.5 part of citric acid. The NAD + composition has the advantages that the preparation process is simple, the prepared NAD + composition has excellent synergy when being compared with some natural plant extract compositions, the effects of resisting aging and tightening skin can be better achieved, the NAD + composition can be effectively absorbed by the skin, the cell regeneration and differentiation capacity is promoted, the resilience force of the skin is helped to be improved, the skin is protected, and the skin is protected. The tightening and anti-aging effects are achieved.

Description

Technical Field

[0001] The present application relates to the field of cosmetic technology, and in particular to a NAD+ composition for skin anti-aging and firming cosmetics and a preparation process thereof. Background Art

[0002] Skin aging is an inevitable experience for the human body. As we age, the appearance, physiological functions and physical properties of the skin change. The skin gradually becomes thinner and loses elasticity. The loss of a large amount of water and collagen causes the skin to become loose, dull and wrinkled. Natural aging of the human body is irreversible. However, due to factors such as fast-paced life, unhealthy lifestyles and mental stress, skin aging is beginning to show a trend of younger people. Consumer demand for anti-aging products is increasing.

[0003] Substances with physiological activities such as anti-free radical, anti-oxidation, anti-radiation, anti-photoaging, anti-bacterial, anti-inflammatory, and repair are widely used in the cosmetics industry. With the restriction of the use of many synthetic chemicals, "green" ingredients are becoming more and more popular.

[0004] Plant-derived active ingredients are very common in anti-aging cosmetics on the market and have certain anti-aging effects, but there is still room for improvement. Therefore, a NAD+ composition for skin anti-aging and firming cosmetics has been developed. Summary of the invention

[0005] The present application provides a NAD+ composition for skin anti-aging and firming cosmetics and its preparation process, so as to solve the problem that the compositions added to existing cosmetics have poor anti-aging effects and cannot effectively promote cell regeneration, thereby achieving better skin anti-aging and firming effects, being effectively absorbed by the skin, promoting cell regeneration and differentiation ability, helping to improve skin resilience, and achieving firming and anti-aging effects.

[0006] The present application provides a NAD+ composition for skin anti-aging and firming cosmetics. The components of the NAD+ composition include, by weight, 40-50 parts of dipropylene glycol, 0.1-1 parts of niacinamide, 0.001-0.01 parts of nicotinamide adenine dinucleotide, 0.05-0.1 parts of β-nicotinamide mononucleotide, 0.1-0.5 parts of alpine edelweiss flower / leaf extract, 0.1-0.5 parts of alpine edelweiss callus extract, 0.1-0.5 parts of alpine edelweiss yeast fermentation lysate filtrate, 0.1-0.5 parts of citric acid, 0.05-0.1 parts of sodium citrate, 0.1-0.3 parts of sodium benzoate, and the remainder water.

[0007] Preferably, the components of the NAD+ composition include, by weight, 45 parts of dipropylene glycol, 0.6 parts of nicotinamide, 0.005 parts of nicotinamide adenine dinucleotide, 0.07 parts of β-nicotinamide mononucleotide, 0.3 parts of alpine edelweiss flower / leaf extract, 0.3 parts of alpine edelweiss callus extract, 0.3 parts of alpine edelweiss yeast fermentation lysate filtrate, 0.3 parts of citric acid, 0.07 parts of sodium citrate, 0.2 parts of sodium benzoate, and the remainder water.

[0008] Preferably, a process for preparing a NAD+ composition for skin anti-aging and firming cosmetics comprises the following steps: A. Dipropylene glycol, nicotinamide, nicotinamide adenine dinucleotide, β-nicotinamide mononucleotide, Leontopodium alpinum flower / leaf extract, Leontopodium alpinum callus extract, and 1 / 2 water are mixed and added into a stirring tank and stirred at a low speed to obtain a mixture A; B. Mix the filtrate of the fermentation lysate of alpine edelweiss yeast, citric acid, sodium citrate, sodium benzoate and 1 / 2 water, add the mixture into a water bath, heat and stir in a water bath, and obtain a mixture B; C. Mixing mixture A and mixture B, and adding the mixture into a three-dimensional mixer to obtain mixture C; D. Finally, the mixture C is stirred and mixed evenly at room temperature to obtain a NAD+ composition.

[0009] Preferably, in step A, the stirring rate is 50-100 rpm and the stirring time is 30 min-40 min.

[0010] Preferably, in step B, the stirring rate is 100-200 rpm, and the stirring time is 10 min-18 min.

[0011] Preferably, in step B, the water bath heating temperature is 45°C-55°C, and the heating time is 10min-15min.

[0012] Preferably, in step C, the mixing rate of the three-dimensional mixer is 40-80 rpm, and the mixing time is 40 min-60 min.

[0013] Preferably, the storage temperature in step D is maintained at 20-25°C.

[0014] Beneficial effects: The preparation process of the present invention is simple, and the prepared NAD+ composition has excellent synergy compared with some natural plant extracts, can better play the role of skin anti-aging and firming, can be effectively absorbed by the skin, promote cell regeneration and differentiation, help improve skin resilience, and achieve firming and anti-aging effects; wherein, the added dipropylene glycol has good water, oil and hydrocarbon co-solubility and has a slight odor, little skin irritation and low toxicity; the added nicotinamide plays a role of hydrogen transfer in the biological oxidation respiratory chain, can promote biological oxidation process and tissue metabolism, and plays an important role in maintaining the integrity of normal tissues; the added nicotinamide adenine dinucleotide is a coenzyme that transfers hydrogen ions, which participates in cell material metabolism, energy synthesis, cell DNA repair and many other Physiological activities; the added β-nicotinamide mononucleotide is one of the key precursors of nicotinamide adenine dinucleotide, which is involved in cellular energy metabolism and signal transduction, and shows potential application value in anti-aging and improving metabolic syndrome; the added alpine edelweiss flower / leaf extract can gently and deeply cleanse the skin, remove epidermal oils and dirt in the pores, and at the same time relieve skin tension, soft and not tight, natural whitening ingredients, can penetrate into the skin, help decompose metabolic impurities, prevent pigmentation, and leave the skin smooth, delicate, white and shiny after use; the added alpine edelweiss callus extract can effectively soothe and calm the skin, and expel harmful substances in the skin; the added alpine edelweiss yeast fermentation lysate filtrate has soothing, calming, whitening and nourishing and protective effects on the skin, and has better whitening, hydrating, moisturizing and anti-wrinkle effects.

[0015] The above description is only an overview of the technical solution of the embodiment of the present application. In order to more clearly understand the technical means of the embodiment of the present application, it can be implemented in accordance with the contents of the specification. In order to make the above and other purposes, features and advantages of the embodiment of the present application more obvious and easy to understand, the specific implementation methods of the present application are listed below. DETAILED DESCRIPTION

[0016] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0017] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by technicians in the technical field to which this application belongs; the terms used in the specification of the application are only for the purpose of describing specific embodiments and are not intended to limit this application.

[0018] Reference to "embodiments" herein means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase "embodiments" in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0019] In order to enable those skilled in the art to better understand the solution of the present application, the technical solution in the embodiments of the present application is clearly and completely described below.

[0020] The present application provides a NAD+ composition for skin anti-aging and firming cosmetics. The components of the NAD+ composition include, by weight, 40-50 parts of dipropylene glycol, 0.1-1 parts of niacinamide, 0.001-0.01 parts of nicotinamide adenine dinucleotide, 0.05-0.1 parts of β-nicotinamide mononucleotide, 0.1-0.5 parts of alpine edelweiss flower / leaf extract, 0.1-0.5 parts of alpine edelweiss callus extract, 0.1-0.5 parts of alpine edelweiss yeast fermentation lysate filtrate, 0.1-0.5 parts of citric acid, 0.05-0.1 parts of sodium citrate, 0.1-0.3 parts of sodium benzoate, and the remainder water.

[0021] Example 1: The components of the NAD+ composition include, by weight, 40 parts of dipropylene glycol, 0.1 parts of nicotinamide, 0.001 parts of nicotinamide adenine dinucleotide, 0.05 parts of β-nicotinamide mononucleotide, 0.1 parts of alpine edelweiss flower / leaf extract, 0.1 parts of alpine edelweiss callus extract, 0.1 parts of alpine edelweiss yeast fermentation lysate filtrate, 0.1 parts of citric acid, 0.05 parts of sodium citrate, 0.1 parts of sodium benzoate, and the remainder of water.

[0022] In this embodiment, a process for preparing a NAD+ composition for skin anti-aging and firming cosmetics comprises the following steps: A. Dipropylene glycol, nicotinamide, nicotinamide adenine dinucleotide, β-nicotinamide mononucleotide, Leontopodium alpinum flower / leaf extract, Leontopodium alpinum callus extract, and 1 / 2 water are mixed and added into a stirring tank and stirred at a low speed to obtain a mixture A; B. Mix the filtrate of the fermentation lysate of alpine edelweiss yeast, citric acid, sodium citrate, sodium benzoate and 1 / 2 water, add the mixture into a water bath, heat and stir in a water bath, and obtain a mixture B; C. Mixing mixture A and mixture B, and adding the mixture into a three-dimensional mixer to obtain mixture C; D. Finally, the mixture C is stirred and mixed evenly at room temperature to obtain a NAD+ composition.

[0023] In this embodiment, the stirring rate in step A is 50 rpm and the stirring time is 30 min.

[0024] In this embodiment, the stirring rate in step B is 100 rpm and the stirring time is 10 min.

[0025] In this embodiment, the water bath heating temperature in step B is 45° C. and the heating time is 10 min.

[0026] In this embodiment, the mixing speed of the three-dimensional mixer in step C is 40 rpm, and the mixing time is 40 min.

[0027] In this embodiment, the storage temperature in step D is maintained at 20°C.

[0028] Example 2: The components of the NAD+ composition include, by weight, 50 parts of dipropylene glycol, 1 part of nicotinamide, 0.01 parts of nicotinamide adenine dinucleotide, 0.1 parts of β-nicotinamide mononucleotide, 0.5 parts of alpine edelweiss flower / leaf extract, 0.5 parts of alpine edelweiss callus extract, 0.5 parts of alpine edelweiss yeast fermentation lysate filtrate, 0.5 parts of citric acid, 0.1 parts of sodium citrate, 0.3 parts of sodium benzoate, and the remainder water.

[0029] In this embodiment, a process for preparing a NAD+ composition for skin anti-aging and firming cosmetics comprises the following steps: A. Dipropylene glycol, nicotinamide, nicotinamide adenine dinucleotide, β-nicotinamide mononucleotide, Leontopodium alpinum flower / leaf extract, Leontopodium alpinum callus extract, and 1 / 2 water are mixed and added into a stirring tank and stirred at a low speed to obtain a mixture A; B. Mix the filtrate of the fermentation lysate of alpine edelweiss yeast, citric acid, sodium citrate, sodium benzoate and 1 / 2 water, add the mixture into a water bath, heat and stir in a water bath, and obtain a mixture B; C. Mixing mixture A and mixture B, and adding the mixture into a three-dimensional mixer to obtain mixture C; D. Finally, the mixture C is stirred and mixed evenly at room temperature to obtain a NAD+ composition.

[0030] In this embodiment, the stirring rate in step A is 100 rpm and the stirring time is 40 min.

[0031] In this embodiment, the stirring rate in step B is 200 rpm and the stirring time is 18 min.

[0032] In this embodiment, the water bath heating temperature in step B is 55° C. and the heating time is 15 min.

[0033] In this embodiment, the mixing speed of the three-dimensional mixer in step C is 80 rpm, and the mixing time is 60 min.

[0034] In this embodiment, the storage temperature in step D is maintained at 25°C.

[0035] Example 3: The components of the NAD+ composition include, by weight, 41 parts of dipropylene glycol, 0.2 parts of nicotinamide, 0.002 parts of nicotinamide adenine dinucleotide, 0.06 parts of β-nicotinamide mononucleotide, 0.2 parts of alpine edelweiss flower / leaf extract, 0.2 parts of alpine edelweiss callus extract, 0.2 parts of alpine edelweiss yeast fermentation lysate filtrate, 0.2 parts of citric acid, 0.06 parts of sodium citrate, 0.2 parts of sodium benzoate, and the remainder water.

[0036] In this embodiment, a process for preparing a NAD+ composition for skin anti-aging and firming cosmetics comprises the following steps: A. Dipropylene glycol, nicotinamide, nicotinamide adenine dinucleotide, β-nicotinamide mononucleotide, Leontopodium alpinum flower / leaf extract, Leontopodium alpinum callus extract, and 1 / 2 water are mixed and added into a stirring tank and stirred at a low speed to obtain a mixture A; B. Mix the filtrate of the fermentation lysate of alpine edelweiss yeast, citric acid, sodium citrate, sodium benzoate and 1 / 2 water, add the mixture into a water bath, heat and stir in a water bath, and obtain a mixture B; C. Mixing mixture A and mixture B, and adding the mixture into a three-dimensional mixer to obtain mixture C; D. Finally, the mixture C is stirred and mixed evenly at room temperature to obtain a NAD+ composition.

[0037] In this embodiment, the stirring rate in step A is 55 rpm and the stirring time is 32 min.

[0038] In this embodiment, the stirring rate in step B is 120 rpm and the stirring time is 12 min.

[0039] In this embodiment, the water bath heating temperature in step B is 46° C. and the heating time is 11 min.

[0040] In this embodiment, the mixing speed of the three-dimensional mixer in step C is 50 rpm, and the mixing time is 43 min.

[0041] In this embodiment, the storage temperature in step D is maintained at 21°C.

[0042] Example 4: The components of the NAD+ composition include, by weight, 49 parts of dipropylene glycol, 0.9 parts of nicotinamide, 0.009 parts of nicotinamide adenine dinucleotide, 0.09 parts of β-nicotinamide mononucleotide, 0.4 parts of alpine edelweiss flower / leaf extract, 0.4 parts of alpine edelweiss callus extract, 0.4 parts of alpine edelweiss yeast fermentation lysate filtrate, 0.4 parts of citric acid, 0.09 parts of sodium citrate, 0.2 parts of sodium benzoate, and the remainder water.

[0043] In this embodiment, a process for preparing a NAD+ composition for skin anti-aging and firming cosmetics comprises the following steps: A. Dipropylene glycol, nicotinamide, nicotinamide adenine dinucleotide, β-nicotinamide mononucleotide, Leontopodium alpinum flower / leaf extract, Leontopodium alpinum callus extract, and 1 / 2 water are mixed and added into a stirring tank and stirred at a low speed to obtain a mixture A; B. Mix the filtrate of the fermentation lysate of alpine edelweiss yeast, citric acid, sodium citrate, sodium benzoate and 1 / 2 water, add the mixture into a water bath, heat and stir in a water bath, and obtain a mixture B; C. Mixing mixture A and mixture B, and adding the mixture into a three-dimensional mixer to obtain mixture C; D. Finally, the mixture C is stirred and mixed evenly at room temperature to obtain a NAD+ composition.

[0044] In this embodiment, the stirring rate in step A is 90 rpm and the stirring time is 38 min.

[0045] In this embodiment, the stirring rate in step B is 180 rpm and the stirring time is 17 min.

[0046] In this embodiment, the water bath heating temperature in step B is 52° C. and the heating time is 14 min.

[0047] In this embodiment, the mixing speed of the three-dimensional mixer in step C is 70 rpm, and the mixing time is 55 min.

[0048] In this embodiment, the storage temperature in step D is maintained at 24°C.

[0049] Example 5: The components of the NAD+ composition include, by weight, 40 parts of dipropylene glycol, 1 part of nicotinamide, 0.001 parts of nicotinamide adenine dinucleotide, 0.1 parts of β-nicotinamide mononucleotide, 0.1 parts of alpine edelweiss flower / leaf extract, 0.5 parts of alpine edelweiss callus extract, 0.1 parts of alpine edelweiss yeast fermentation lysate filtrate, 0.5 parts of citric acid, 0.05 parts of sodium citrate, 0.3 parts of sodium benzoate, and the remainder of water.

[0050] In this embodiment, a process for preparing a NAD+ composition for skin anti-aging and firming cosmetics comprises the following steps: A. Dipropylene glycol, nicotinamide, nicotinamide adenine dinucleotide, β-nicotinamide mononucleotide, Leontopodium alpinum flower / leaf extract, Leontopodium alpinum callus extract, and 1 / 2 water are mixed and added into a stirring tank and stirred at a low speed to obtain a mixture A; B. Mix the filtrate of the fermentation lysate of alpine edelweiss yeast, citric acid, sodium citrate, sodium benzoate and 1 / 2 water, add the mixture into a water bath, heat and stir in a water bath, and obtain a mixture B; C. Mixing mixture A and mixture B, and adding the mixture into a three-dimensional mixer to obtain mixture C; D. Finally, the mixture C is stirred and mixed evenly at room temperature to obtain a NAD+ composition.

[0051] In this embodiment, the stirring rate in step A is 80 rpm and the stirring time is 34 min.

[0052] In this embodiment, the stirring rate in step B is 140 rpm and the stirring time is 15 min.

[0053] In this embodiment, the water bath heating temperature in step B is 48° C. and the heating time is 12 min.

[0054] In this embodiment, the mixing speed of the three-dimensional mixer in step C is 55 rpm, and the mixing time is 54 min.

[0055] In this embodiment, the storage temperature in step D is maintained at 22°C.

[0056] Example 6: The components of the NAD+ composition include, by weight, 50 parts of dipropylene glycol, 0.1 parts of nicotinamide, 0.01 parts of nicotinamide adenine dinucleotide, 0.05 parts of β-nicotinamide mononucleotide, 0.5 parts of alpine edelweiss flower / leaf extract, 0.1 parts of alpine edelweiss callus extract, 0.5 parts of alpine edelweiss yeast fermentation lysate filtrate, 0.1 parts of citric acid, 0.1 parts of sodium citrate, 0.1 parts of sodium benzoate, and the remainder of water.

[0057] In this embodiment, a process for preparing a NAD+ composition for skin anti-aging and firming cosmetics comprises the following steps: A. Dipropylene glycol, nicotinamide, nicotinamide adenine dinucleotide, β-nicotinamide mononucleotide, Leontopodium alpinum flower / leaf extract, Leontopodium alpinum callus extract, and 1 / 2 water are mixed and added into a stirring tank and stirred at a low speed to obtain a mixture A; B. Mix the filtrate of the fermentation lysate of alpine edelweiss yeast, citric acid, sodium citrate, sodium benzoate and 1 / 2 water, add the mixture into a water bath, heat and stir in a water bath, and obtain a mixture B; C. Mixing mixture A and mixture B, and adding the mixture into a three-dimensional mixer to obtain mixture C; D. Finally, the mixture C is stirred and mixed evenly at room temperature to obtain a NAD+ composition.

[0058] In this embodiment, the stirring rate in step A is 100 rpm and the stirring time is 30 min.

[0059] In this embodiment, the stirring rate in step B is 200 rpm and the stirring time is 10 min.

[0060] In this embodiment, the water bath heating temperature in step B is 55° C. and the heating time is 10 min.

[0061] In this embodiment, the mixing speed of the three-dimensional mixer in step C is 80 rpm, and the mixing time is 40 min.

[0062] In this embodiment, the storage temperature in step D is maintained at 24°C.

[0063] Example 7: The components of the NAD+ composition include, by weight, 45 parts of dipropylene glycol, 0.6 parts of nicotinamide, 0.005 parts of nicotinamide adenine dinucleotide, 0.07 parts of β-nicotinamide mononucleotide, 0.3 parts of alpine edelweiss flower / leaf extract, 0.3 parts of alpine edelweiss callus extract, 0.3 parts of alpine edelweiss yeast fermentation lysate filtrate, 0.3 parts of citric acid, 0.07 parts of sodium citrate, 0.2 parts of sodium benzoate, and the remainder water.

[0064] In this embodiment, a process for preparing a NAD+ composition for skin anti-aging and firming cosmetics comprises the following steps: A. Dipropylene glycol, nicotinamide, nicotinamide adenine dinucleotide, β-nicotinamide mononucleotide, Leontopodium alpinum flower / leaf extract, Leontopodium alpinum callus extract, and 1 / 2 water are mixed and added into a stirring tank and stirred at a low speed to obtain a mixture A; B. Mix the filtrate of the fermentation lysate of alpine edelweiss yeast, citric acid, sodium citrate, sodium benzoate and 1 / 2 water, add the mixture into a water bath, heat and stir in a water bath, and obtain a mixture B; C. Mixing mixture A and mixture B, and adding the mixture into a three-dimensional mixer to obtain mixture C; D. Finally, the mixture C is stirred and mixed evenly at room temperature to obtain a NAD+ composition.

[0065] In this embodiment, the stirring rate in step A is 75 rpm and the stirring time is 35 min.

[0066] In this embodiment, the stirring rate in step B is 150 rpm and the stirring time is 14 min.

[0067] In this embodiment, the water bath heating temperature in step B is 50° C. and the heating time is 14 min.

[0068] In this embodiment, the mixing speed of the three-dimensional mixer in step C is 60 rpm, and the mixing time is 50 min.

[0069] In this embodiment, the storage temperature in step D is maintained at 23°C.

[0070] Comparative Example: The composition comprises 42 parts of dipropylene glycol, 0.7 parts of nicotinamide, 0.002 parts of nicotinamide adenine dinucleotide, 0.02 parts of β-nicotinamide mononucleotide, 0.4 parts of citric acid, 0.03 parts of sodium citrate, 0.1 parts of sodium benzoate, and the balance of water.

[0071] Experimental example: The NAD+ composition prepared by each embodiment of the present invention is tested for NAD+ concentration in each embodiment using NAD+ / NADH detection kit (WST-8 method) with reference to its instructions, and the data obtained are as follows: In addition, the skin care products containing the NAD+ composition of the present invention were applied to the face for one month, and the content of skin structural protein was measured using a Cortex skin detector + skin ultrasound probe. The data obtained are as follows: From the above table data, we can see that the increase of NAD+ concentration can effectively increase skin elastin. Reduce the loss of collagen, thereby playing an anti-aging and firming role on the skin.

[0072] The INCI name of NAD+ is Nicotinamide Adenine Dinucleotide, which can be found in the [Catalogue of Used Cosmetic Ingredients].

[0073] In addition, in the article "The Renaissance of NAD+" published in Science, scientists confirmed that one of the fundamental reasons for aging is that DNA in cells and mitochondria, the energy factories, gradually accumulate damage with age. The accumulation of DNA damage also leads to a decrease in the body's ability to synthesize NAD+, so that the content of NAD+ in the human body begins to decrease rapidly after the age of 30. The decrease in NAD+, in turn, leads to a decrease in DNA repair ability, further accelerating the accumulation of DNA damage.

[0074] Braidy et al. (2011) recorded that NAD+ is a key component for maintaining cell metabolism and function, and is present in various tissues such as the skin. They discussed the importance of NAD+ in the aging process and pointed out that aging can cause a decrease in NAD+ levels, which may affect the skin's ability to repair itself. The dipropylene glycol added in the present invention has good water, oil and hydrocarbon co-solubility, and has a slight odor, little skin irritation, and low toxicity; the added nicotinamide plays a role in hydrogen transfer in the biological oxidation respiratory chain, which can promote biological oxidation processes and tissue metabolism, and plays an important role in maintaining the integrity of normal tissues; the added nicotinamide adenine dinucleotide is a coenzyme that transfers hydrogen ions, which participates in various physiological activities such as cell metabolism, energy synthesis, and cell DNA repair; the added β-nicotinamide mononucleotide is a nicotinamide adenine dinucleotide. One of the key precursors, it participates in cell energy metabolism and signal transduction, and shows potential application value in anti-aging and improving metabolic syndrome. The added alpine edelweiss flower / leaf extract can gently and deeply cleanse the skin, remove epidermal oils and dirt in the pores, while relieving skin tension. It is soft and not tight. The natural whitening ingredient can penetrate into the skin, help decompose metabolic impurities, and prevent pigmentation. After use, the skin will be smooth, delicate, white and shiny. The added alpine edelweiss callus extract can effectively soothe and calm the skin, and expel harmful substances in the skin. The added alpine edelweiss yeast fermentation lysate filtrate has a soothing, calming, whitening and nourishing protective effect on the skin, and has better whitening, hydrating, moisturizing and anti-wrinkle effects.

[0075] In summary, the preparation process of the present invention is simple, and the prepared NAD+ composition has excellent synergy compared with some natural plant extracts, can better play the role of skin anti-aging and firming, can be effectively absorbed by the skin, promote cell regeneration and differentiation ability, help improve skin resilience, and achieve firming and anti-aging effects.

[0076] As described above, the above embodiments are only used to illustrate the technical solutions of the present application, rather than to limit them. Although the present application has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present application.

Claims

1. A NAD+ composition for skin anti-aging and firming cosmetics, characterized in that: The components of the NAD+ composition include 40-50 parts of dipropylene glycol, 0.1-1 parts of nicotinamide, 0.001-0.01 parts of nicotinamide adenine dinucleotide, 0.05-0.1 parts of β-nicotinamide mononucleotide, 0.1-0.5 parts of alpine edelweiss flower / leaf extract, 0.1-0.5 parts of alpine edelweiss callus extract, 0.1-0.5 parts of alpine edelweiss yeast fermentation lysate filtrate, 0.1-0.5 parts of citric acid, 0.05-0.1 parts of sodium citrate, 0.1-0.3 parts of sodium benzoate, and the balance water.

2. The NAD+ composition for skin anti-aging and firming cosmetics according to claim 1, characterized in that: The components of the NAD+ composition include, by weight, 45 parts of dipropylene glycol, 0.6 parts of nicotinamide, 0.005 parts of nicotinamide adenine dinucleotide, 0.07 parts of β-nicotinamide mononucleotide, 0.3 parts of alpine edelweiss flower / leaf extract, 0.3 parts of alpine edelweiss callus extract, 0.3 parts of alpine edelweiss yeast fermentation lysate filtrate, 0.3 parts of citric acid, 0.07 parts of sodium citrate, 0.2 parts of sodium benzoate, and the remainder of water.

3. A process for preparing a NAD+ composition for skin anti-aging and firming cosmetics according to claim 1, characterized in that: The preparation process comprises the following steps: A. Dipropylene glycol, nicotinamide, nicotinamide adenine dinucleotide, β-nicotinamide mononucleotide, Leontopodium alpinum flower / leaf extract, Leontopodium alpinum callus extract, and 1 / 2 water are mixed and added into a stirring tank and stirred at a low speed to obtain a mixture A; B. Mix the filtrate of the fermentation lysate of alpine edelweiss yeast, citric acid, sodium citrate, sodium benzoate and 1 / 2 water, add the mixture into a water bath, heat and stir in a water bath, and obtain a mixture B; C. Mixing mixture A and mixture B, and adding the mixture into a three-dimensional mixer to obtain mixture C; D. Finally, the mixture C is stirred and mixed evenly at room temperature to obtain a NAD+ composition.

4. The process for preparing a NAD+ composition for skin anti-aging and firming cosmetics according to claim 3, characterized in that: In step A, the stirring rate is 50-100 rpm, and the stirring time is 30 min-40 min.

5. The process for preparing a NAD+ composition for skin anti-aging and firming cosmetics according to claim 3, characterized in that: In step B, the stirring rate is 100-200 rpm, and the stirring time is 10 min-18 min.

6. The process for preparing a NAD+ composition for skin anti-aging and firming cosmetics according to claim 5, characterized in that: In step B, the water bath heating temperature is 45° C.-55° C., and the heating time is 10 min-15 min.

7. The process for preparing a NAD+ composition for skin anti-aging and firming cosmetics according to claim 3, characterized in that: In step C, the mixing rate of the three-dimensional mixer is 40-80 rpm, and the mixing time is 40 min-60 min.

8. The process for preparing a NAD+ composition for skin anti-aging and firming cosmetics according to claim 3, characterized in that: In step D, the storage temperature is maintained at 20-25°C.

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