Penetrating blood stasis removing and toxin expelling pharmaceutical composition as well as preparation method and application thereof

Abstract

The invention provides an osmotic blood stasis removing and toxin expelling pharmaceutical composition which is prepared from the following raw material medicines in parts by weight: 79-100 parts of a foaming component, 6-10 parts of a component for promoting blood circulation to remove blood stasis, 4-10 parts of a pain relieving component, 1-5 parts of a component for clearing away heat and toxic materials and 1-5 parts of a component for guiding meridians and collaterals, and a preparation containing the pharmaceutical composition has an outstanding clinical effect in treating diseases caused by qi stagnation and blood stasis.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine, and in particular to a drug composition for penetrating blood stasis and detoxifying, a preparation method and application thereof. Background Art

[0002] According to traditional Chinese medicine, poisons invade the human body, block the qi, consume qi and blood, and destroy the normal operation of the internal organs, meridians, qi and blood, and the Yingwei, thus causing diseases and aging. Qi is insufficient and blood is blocked. Once the body is blocked, various diseases will follow. Stagnation in the heart manifests as chest tightness, heartache, cardiovascular problems, etc.; Stagnation in the lungs manifests as dyspnea, coughing, and allergic rhinitis; Stagnation in the brain manifests as headache, dizziness, dementia, and memory loss. As long as the qi and blood are unblocked and the qi and blood are replenished, the body's self-healing ability will automatically start and play a role. Qi and blood have the same origin, and they influence and cooperate with each other. Qi is mainly smooth, and blood is smooth. By eliminating stasis, stasis, and toxins, raising the clear and lowering the turbid, the circulation of qi and blood is the most basic substance to maintain human life activities, and its importance is self-evident. In the prior art, the application of Sanjiu patch through skin penetration technology can relieve some pain to a certain extent, but it basically needs to be applied every year, and it is difficult to eradicate and cure. For example, the formula of Sanjiu patch: 20g white mustard, 20g Corydalis, 10g Asarum, 10g Atractylodes, 10g Cinnamon, 10g Licorice; crush into powder with a crusher, then grind ginger into ginger juice, mix with the powder into balls, and apply on the acupuncture points. Acupuncture points for application: Dazhui, Feishu, Gaoshu, Tanzhong, Guanyuan. Another example is the formula of Sanjiu patch: 20g white mustard, 20g Corydalis, 10g Asarum, 10g Atractylodes, 10g Atractylodes, 10g Gansui. Mix with ginger juice and apply a small plaster. These prescriptions only relieve some pains to a certain extent, and it is difficult to cure them. There are few indications, especially difficult and complicated diseases. Summary of the invention

[0003] The present invention provides a osmotic stasis-removing and detoxifying pharmaceutical composition, a preparation method, and application of the pharmaceutical composition in treating diseases caused by stasis. The present invention provides a osmotic stasis-removing and detoxifying pharmaceutical composition, which is prepared from the following raw materials in parts by weight: 79-100 parts of a foaming component, 6-10 parts of a blood circulation and stasis-removing component, 4-10 parts of an analgesic component, 1-5 parts of a heat-clearing and detoxifying component, and 1-5 parts of a meridian guiding component.

[0004] Preferably, the foaming component is white mustard, the blood circulation and stasis removing component is Panax notoginseng or Chuanxiong, the analgesic component is Corydalis, the heat-clearing and detoxifying component is Scutellaria baicalensis, and the meridian guiding component is Gleditsia sinensis or Angelica dahurica. Preferably, 80 parts of white mustard, 8 parts of Panax notoginseng, 6 parts of Corydalis, 3 parts of Scutellaria baicalensis, and 3 parts of Gleditsia sinensis. Preferably, 75 parts of white mustard, 10 parts of Chuanxiong, 5 parts of Corydalis, 5 parts of Scutellaria baicalensis, and 5 parts of Angelica dahurica.

[0005] The Chinese medicine composition of the osmotic blood stasis-removing and toxin-removing medicinal composition of the present invention is prepared by taking the components of the medicinal composition respectively according to the proportion by mass, grinding them into fine powder, mixing them evenly, and adjusting them into a paste with mashed garlic and medical alcohol.

[0006] The present invention also provides a traditional Chinese medicine composition containing the infiltration blood stasis removal and detoxification drug composition, including medicine powder and medicine wine, wherein the medicine powder is prepared by respectively taking each component in the medicine composition in proportion by mass, grinding into fine powder, mixing evenly, and placing in a glass bottle in a cool place; the medicine wine is prepared by proportioning Chinese herbal medicine and sorghum liquor with a concentration of more than 58 degrees, soaking in a ceramic jar or a glass jar, and stirring evenly; the Chinese herbal medicine refers to a mixture of licorice root, mint, calendula, and polygonatum, and the licorice root, mint, calendula, and polygonatum are in equal mass ratios.

[0007] The Chinese medicine composition preparation of the present invention is in the form of tablets, pills, or dripping pills.

[0008] The present invention also provides a preparation method of the preparation, comprising: (1) preparing medicinal powder, weighing 79-100 parts of a foaming component, 6-10 parts of a blood circulation and blood stasis removing component, 4-10 parts of a pain relieving component, 1-5 parts of a heat-clearing and detoxifying component, and a meridian guiding component, and grinding them into fine powder, mixing them evenly, and placing them in a glass bottle in a cool place; (2) preparing medicinal liquor, ① preparing a mixture of mashed garlic and medical alcohol, wherein the mass ratio of the mashed garlic to the medical alcohol is 3-6:1; or ② preparing liquorice root, mint, calendula, polygonatum odoratum and 58-proof kaoliang liquor in equal mass ratios, soaking them in a ceramic jar or a glass jar, and stirring them evenly, wherein the proportion preparation refers to a mass ratio of the Chinese herbal medicine to the kaoliang liquor of 1-10:1; (3) mixing the medicinal powder with the medicinal liquor, mixing the medicinal powder of step (1) and the medicinal liquor of step (2) in a mass ratio of 2-10:1, thereby preparing the preparation.

[0009] The infiltration blood stasis and detoxification drug composition, the Chinese medicine composition and the preparation of the present invention have unique effects. When applied, the "medicine powder + medicinal wine" is prepared into a paste for application to the diseased area outside the body for detoxification. This therapy integrates the six traditional treatment methods of traditional Chinese medicine, namely "medicine + acupoints + application + foaming + cyclic cupping + cyclic bloodletting" as an integrated detoxification process therapy, until natural scab healing occurs to achieve the effects of blood stasis removal, detoxification and blood circulation.

[0010] The present invention also provides the use of the osmotic blood stasis-removing and toxin-removing medicinal composition in the preparation of medicines for treating diseases caused by qi stagnation and blood stasis.

[0011] Preferably, the diseases caused by qi stagnation and blood stasis include painful diseases, nervous system diseases, digestive system diseases, gynecological diseases, respiratory system diseases, immune system diseases, cardiovascular diseases, kidney diseases, skin diseases, tumors, and senile diseases such as dementia. Preferably, the painful diseases include cervical spondylosis, lumbar spondylosis, frozen shoulder, knee joint disease, and muscle and tendon pain; the nervous system diseases include stroke, headache, insomnia, and epilepsy; the digestive system diseases include gastrointestinal pain, constipation, indigestion, and hepatitis; the gynecological diseases include irregular menstruation, dysmenorrhea, uterine fibroids, and ovarian cysts; the respiratory system diseases include asthma, cough, bronchitis, and emphysema; the immune system diseases include rheumatoid arthritis and rheumatic heart disease; the cardiovascular diseases include coronary heart disease, hypertension, arrhythmia, myocardial infarction, and cerebral infarction; the kidney diseases include nephritis, kidney stones, and renal insufficiency; the skin diseases include dermatitis, eczema, and chloasma; the tumors include hematological tumors and solid tumors; the dementia includes qi stagnation and blood stasis dementia / vascular dementia, and reversible dementia. Preferably, the painful diseases include cervical spondylosis, lumbar spondylosis, frozen shoulder, knee joint disease, and muscle and tendon pain; the nervous system diseases include stroke, headache, insomnia, and epilepsy; the digestive system diseases include gastrointestinal pain, constipation, indigestion, and hepatitis; the gynecological diseases include irregular menstruation, dysmenorrhea, uterine fibroids, and ovarian cysts; the respiratory system diseases include asthma, cough, bronchitis, and emphysema; the immune system diseases include rheumatoid arthritis and rheumatic heart disease; the cardiovascular diseases include coronary heart disease, hypertension, arrhythmia, myocardial infarction, and cerebral infarction; the kidney diseases include nephritis, kidney stones, and renal insufficiency; the skin diseases include dermatitis, eczema, and chloasma; the tumors include hematological tumors and solid tumors; the dementia includes qi stagnation and blood stasis dementia / vascular dementia, and reversible dementia. Implementation

[0012] Traditional Chinese medicine says that "blood is the mother of qi, and qi is the commander of blood". Qi and blood are one yin and one yang. Qi is invisible and moving, belonging to yang; blood is visible and static, belonging to yin. Without the command and promotion of qi, blood cannot reach the places where the body needs it; without blood as a foundation, qi becomes the evil fire in the body. Traditional Chinese medicine says that "all diseases are caused by qi" and qi stagnation and blood stasis. Things are transformed by the mind, and the environment is created by the mind. Traditional Chinese medicine believes that poisons invade the human body, which can block the qi mechanism, consume qi and blood, and destroy the normal operation of the internal organs, meridians, qi and blood, and the nutrient and defensive systems, thus causing diseases and aging. Qi is insufficient and blood is blocked. Once the body is blocked, various diseases will follow. Stagnation in the heart manifests as chest tightness, heartache, cardiovascular problems, etc.; Stagnation in the lungs manifests as difficulty breathing, coughing, and allergic rhinitis; Stagnation in the brain manifests as headaches, dizziness, dementia, and memory loss. Therefore, if you can keep your Qi and blood flowing smoothly, you can prevent all kinds of diseases. Once your Qi and blood are replenished, the body's self-healing ability will automatically activate and take effect.

[0013] The present invention provides a topical pharmaceutical composition, which is a green medical treatment of a unique therapy for treating existing diseases and preventing and treating future diseases through traditional Chinese medicine, achieving the clinical effect of external treatment of internal diseases and quick treatment of chronic diseases. It is the most basic substance for maintaining human life activities by eliminating blockages, stasis and toxins, raising the clear and lowering the turbid, and promoting the circulation of qi and blood, and its importance is self-evident. "Qi and blood have the same origin", they influence and cooperate with each other. The main thing about qi is smoothness, and the main thing about blood is unobstructedness. After more than 30 years of scientific research and clinical research and observation of the efficacy of tens of thousands of patients, the implementation of the functional positioning of medical technology has been continuously improved in practice.

[0014] The "permeation and detoxification" therapy is to apply Chinese medicine to the corresponding parts of the human epidermal disease to complete the treatment. No medicine, no infusion, and no surgery are required during the entire treatment process, so it is safe and healthy for the human body and is deeply trusted by patients. Its medical characteristics can be summarized in 16 words, namely "external treatment of internal diseases, quick treatment of chronic diseases, simultaneous treatment of multiple diseases, and treatment of both the symptoms and the root causes." Detoxification, blood stasis removal, and repair of pipelines are the biggest projects for repairing human functions. The pharmaceutical composition provided by the present invention eliminates toxins in the body by removing blockages and purging toxins, and serves patients with internal diseases and external treatment.

[0015] As one of the embodiments, a pharmaceutical composition, a preparation method, and the use of the pharmaceutical composition in treating diseases caused by blockage are provided. As one of the embodiments, a pharmaceutical composition is provided, which is made of the following raw materials in parts by weight: 79-100 parts of foaming component, 6-10 parts of blood circulation and stasis removal component, 4-10 parts of analgesic component, 1-5 parts of heat-clearing and toxic-removing component, and 1-5 parts of meridian guiding component. As one of the embodiments, the foaming component is white mustard, the blood circulation and stasis removal component is Panax notoginseng or Chuanxiong, the analgesic component is Corydalis, the heat-clearing and toxic-removing component is Scutellaria baicalensis, and the meridian guiding component is Gleditsia sinensis or Angelica dahurica. As one of the embodiments, 80 parts of white mustard, 8 parts of Panax notoginseng, 6 parts of Corydalis, 3 parts of Scutellaria baicalensis, and 3 parts of Gleditsia sinensis. As one of the embodiments, 75 parts of white mustard, 10 parts of Chuanxiong, 5 parts of Corydalis, 5 parts of Scutellaria baicalensis, and 5 parts of Angelica dahurica. As one of the embodiments, the Chinese medicine composition of the pharmaceutical composition is made by taking each component of the pharmaceutical composition in proportion by mass, beating into fine powder, mixing evenly, and adjusting into a paste with mashed garlic and medical alcohol. As one of the embodiments, the Chinese medicine composition of the pharmaceutical composition includes medicinal powder and medicinal wine, and the medicinal powder is made by taking each component of the pharmaceutical composition in proportion by mass, beating into fine powder, mixing evenly, and placing in a glass bottle in a cool place; the medicinal wine is a mixture of Chinese herbal medicine and 58-degree or above kaoliang liquor in proportion, soaking in a ceramic jar or glass jar, and stirring evenly; the Chinese herbal medicine refers to a mixture of licorice root, mint, calendula, and polygonatum, and the licorice root, mint, calendula, and polygonatum are in equal mass ratios. As one of the embodiments, the Chinese medicine composition preparation is in the form of tablets, pills, or drip pills. As one of the embodiments, a preparation method of the preparation is also provided, which comprises: (1) preparing the medicinal powder, weighing 79-100 parts of the foaming component, 6-10 parts of the blood circulation and blood stasis removing component, 4-10 parts of the analgesic component, 1-5 parts of the heat-clearing and detoxifying component, and the meridian guiding component in proportion, grinding them into fine powder, mixing them evenly, and placing them in a glass bottle in a cool place; (2) preparing the medicinal liquor, ① preparing a mixture of mashed garlic and medical alcohol, wherein the mass ratio of the mashed garlic to the medical alcohol is 3-6:1; or ② preparing liquorice root, mint, calendula, polygonatum odoratum and 58-proof kaoliang liquor in equal mass ratios in proportion, soaking them in a ceramic jar or a glass jar, and stirring them evenly, wherein the proportion preparation refers to that the mass ratio of the Chinese herbal medicine to the kaoliang liquor is 1-10:1; (3) mixing the medicinal powder with the medicinal liquor, mixing the medicinal powder of step (1) and the medicinal liquor of step (2) in a mass ratio of 2-10:1, thereby preparing the preparation. As one of the embodiments, the use of the pharmaceutical composition in the preparation of a drug for treating a disease caused by qi stagnation and blood stasis is also provided. As one of the embodiments, the disease caused by qi stagnation and blood stasis includes painful diseases, nervous system diseases, digestive system diseases, gynecological diseases, respiratory system diseases, immune system diseases, cardiovascular diseases, kidney diseases, skin diseases, tumors, and senile diseases such as dementia.

[0016] As one of the embodiments, the painful diseases include cervical spondylosis, lumbar spondylosis, frozen shoulder, knee joint disease, and muscle and bone pain; the nervous system diseases include stroke, headache, insomnia, and epilepsy; the digestive system diseases include gastrointestinal pain, constipation, indigestion, and hepatitis; the gynecological diseases include irregular menstruation, dysmenorrhea, uterine fibroids, and ovarian cysts; the respiratory system diseases include asthma, cough, bronchitis, and emphysema; the immune system diseases include rheumatoid arthritis and rheumatic heart disease; the cardiovascular diseases include coronary heart disease, hypertension, arrhythmia, myocardial infarction, and cerebral infarction; the kidney diseases include nephritis, kidney stones, and renal insufficiency; the skin diseases include dermatitis, eczema, and chloasma; the tumors include hematological tumors and solid tumors; the dementia includes qi stagnation and blood stasis type dementia / vascular dementia, and reversible dementia. As one of the embodiments, the painful diseases include cervical spondylosis, lumbar spondylosis, frozen shoulder, knee joint disease, muscle and tendon pain; the nervous system diseases include stroke, headache, insomnia, epilepsy; the digestive system diseases include gastrointestinal pain, constipation, indigestion, hepatitis; the gynecological diseases include irregular menstruation, dysmenorrhea, uterine fibroids, ovarian cysts; the respiratory system diseases include asthma, cough, bronchitis, emphysema; the immune system diseases include rheumatoid arthritis and rheumatic heart disease; the cardiovascular diseases include coronary heart disease, hypertension, arrhythmia, myocardial infarction, cerebral infarction; the kidney diseases include nephritis, kidney stones, renal insufficiency; the skin diseases include dermatitis, eczema, chloasma; the tumors include hematological tumors and solid tumors; the dementia includes qi stagnation and blood stasis type dementia / vascular dementia, and reversible dementia. More preferably, the therapeutic effect is significant for various tumors, cerebral infarction, pain caused by various injuries, joint inflammation, cough and asthma caused by respiratory diseases.

[0017] Example 1

[0018] The preparation method of a Chinese medicine composition is as follows: (1) preparing medicinal powder, weighing 80 grams of white mustard seeds, 8 grams of Panax notoginseng, 6 grams of Corydalis, 3 grams of Scutellaria baicalensis, 3 grams of Gleditsia sinensis, and meridian guiding components in proportion, grinding them into fine powder, mixing them evenly, and placing them in a glass bottle in a cool place; (2) preparing medicinal wine, ① preparing a mixture of mashed garlic and medical alcohol, wherein the mass ratio of the mashed garlic to the medical alcohol is 6:1; (3) mixing the medicinal powder with the medicinal wine, mixing the medicinal powder of step (1) and the medicinal wine of step (2) in a mass ratio of 2:1, thereby preparing the preparation.

[0019] Example 2

[0020] The preparation method of the Chinese medicine composition is as follows: (1) preparing the medicine powder, weighing 75 parts of white mustard seeds, 10 parts of Chuanxiong, 5 parts of Corydalis, 5 parts of Scutellaria baicalensis, 5 parts of Angelica dahurica, and meridian guiding components according to proportion, grinding them into fine powder, mixing them evenly, and placing them in a glass bottle in a cool place; (2) preparing the medicinal wine, ② mixing 3 grams of licorice root, 3 grams of mint, 3 grams of calendula, 3 grams of polygonatum odoratum and 58 degrees or more sorghum liquor in an equal mass ratio of 2:5, soaking them in a ceramic jar or a glass jar, and stirring them evenly; (3) mixing the medicine powder with the medicinal wine, mixing the medicine powder of step (1) and the medicinal wine of step (2) in a mass ratio of 3:1, so as to prepare the preparation.

[0021] The pharmaceutical composition, Chinese medicine composition and preparation of the present invention have unique efficacy. When applied, "medicine powder + medicinal wine" is prepared into a paste for application to the external diseased area for detoxification. This therapy integrates the six traditional treatment methods of traditional Chinese medicine, namely "medicine + acupoint + application + foaming + circular cupping + circular bloodletting" detoxification process integrated therapy, until natural scab healing is achieved to achieve the effects of removing blood stasis, detoxification and blood circulation. Unless otherwise specified, the following clinical experiments are all based on the clinical method of medicine + acupoint + application + foaming + circular cupping + circular bloodletting. Among them, for acupoint application: the drug is made into a certain dosage form and applied to the acupoints of the human body. It is an operation method that stimulates the acupoints and stimulates the meridians to achieve the effects of dredge the meridians, clear away heat and detoxify, promote blood circulation and remove blood stasis, reduce swelling and relieve pain, and strengthen the body. Acupoint application is suitable for: 1. Indications: local (such as cervical spondylosis, leg joints, ankle joints, lumbar joints) congestion, special parts including malignant tumors, pain caused by various injuries, abdominal distension, diarrhea, constipation caused by digestive system diseases, cough and asthma caused by respiratory diseases. Congestion in the cervical artery, stomach, heart, hemiplegia caused by stroke, prostate disease, varicose veins, etc. 2. Principle of treatment: Traditional Chinese medicine proposes that "the human body has no disease, only because of congestion and blockage". This therapy can disperse the congestion in the lesion area in the body, remove the cold poison in the body, dredge the meridians, let the blood and qi reach every part of the body smoothly, and help the human body complete self-repair and achieve recovery. 3. Efficacy: Through one or more courses of treatment, the corresponding disease can be cured or significantly improved.

[0022] Clinical treatment-patients with hemiplegia caused by stroke in rehabilitation: general data 108 patients diagnosed with hemiplegia caused by stroke who visited the rehabilitation hospital from February 2018 to June 2023 were selected and randomly divided into two groups. There were 27 cases in treatment group 1, including 13 males and 14 females, aged 45-76 years old; there were 81 cases in control group 1-3, with 27 cases in each control group, 13 males and 14 females in each group, aged 45-78 years old, and there was no statistically significant difference in the general data of the two groups of patients (P>0.05) and they were comparable. There were 27 cases in treatment group 2, including 13 males and 14 females, aged 42-75 years old; there were 81 cases in control group 4-6, with 27 cases in each control group, 13 males and 14 females in each group, aged 41-75 years old, and there was no statistically significant difference in the general data of the two groups of patients (P>0.05) and they were comparable.

[0023] All the above patients were clinically diagnosed as sequelae (not acute or recovery) by regular hospitals, and were not bedridden or could only walk with the aid of a wheelchair, crutches or support. The clinical endpoint of this experiment was that the patient could walk independently and the hemiplegia symptoms were significantly reduced or completely disappeared. For all treatment groups and control groups, the performance on the 7th day after the eighth cupping was used as the time window for judging the efficacy and whether the experimental endpoint was reached.

[0024] Unless otherwise specified, the present invention or the following specific embodiments, especially the clinical experimental process, are all treated according to the following method steps. As one of the specific embodiments, the operation process includes: 1. Acupoint application (foaming), generally one foaming is one application, and then uncovered after 24-36 hours; 2. Cleaning toxins (inside the bubble); 3. Cupping (cleaning pipeline clogging substances); 4. Disinfection; 5. Applying acupoints (wounds) to prevent scabs on the wounds (to prevent clogging of pipelines or channels from being sealed) affecting detoxification; 6. Doctors advise to drink more water and eat light meals; 7. Cupping once every morning; 8. The detoxification opening gradually shrinks (with local itching). After the toxins are discharged, the itching symptoms disappear on their own; 9. After the toxins are discharged, the wound surface returns to normal skin.

[0025] Inclusion and Exclusion Criteria: Patients who meet the diagnostic criteria will be included in the clinical trial study. Exclusion criteria are: (1) those under 40 years old or over 85 years old, those with allergic constitution or allergic to the drug; (2) those with serious primary diseases such as cardiovascular, liver, kidney and hematopoietic system, and mental illness; (3) those who do not meet the inclusion criteria, do not use the drug according to the prescribed method, cannot judge the efficacy, or have incomplete data that affect the judgment of efficacy or safety.

[0026] Treatment group 1: The medication regimen is to apply the preparation prepared by the method of Example 1 of the present invention, which is applied once and cupping is performed eight times. Control group 1: The preparation of the same specifications mainly composed of excipients without the active ingredient Gleditsia sinensis of the present invention is applied, which is applied once and cupping is performed eight times. The preparation method of the drug in control group 1 is the same as that in Example 1, except that the Gleditsia sinensis component is not selected. Control group 2: The preparation of the same specifications mainly composed of excipients without the active ingredient Panax notoginseng of the present invention is applied, which is applied once and cupping is performed eight times. The preparation method of the drug in control group 2 is the same as that in Example 1, except that the Panax notoginseng component is not selected. Control group 3: The preparation of the same specifications mainly composed of excipients without the active ingredients Panax notoginseng and Gleditsia sinensis of the present invention is applied, which is applied once and cupping is performed eight times. The preparation method of the drug in control group 3 is the same as that in Example 1, except that Panax notoginseng and Gleditsia sinensis components are not selected. Treatment group 2: The medication regimen is to apply the preparation prepared by the method of Example 2 of the present invention, which is applied once and cupping is performed eight times. Control group 4: Apply a preparation of the same specifications consisting of mainly excipients without the effective ingredient Angelica dahurica of the present invention, apply once in total, and cupping eight times. The preparation method of the drug in control group 4 is the same as that in Example 2, except that the Angelica dahurica component is not selected. Control group 5: Apply a preparation of the same specifications consisting of mainly excipients without the effective ingredient Chuanxiong of the present invention, apply once in total, and cupping eight times. The preparation method of the drug in control group 5 is the same as that in Example 2, except that the Chuanxiong component is not selected. Control group 6: Apply a preparation of the same specifications consisting of mainly excipients without the effective ingredients Angelica dahurica and Chuanxiong of the present invention, apply once in total, and cupping eight times; The preparation method of the drug in control group 6 is the same as that in Example 2, except that the Angelica dahurica and Chuanxiong components are not selected.

[0027] Through the experiments of the treatment group and the control group, the results are as follows: 100% of the treatment group 1 reached the expected experimental endpoint standard, 50% of the control group 1 reached the expected experimental endpoint standard, 0% of the control group 2 reached the expected experimental endpoint standard, 0% of the control group 3 reached the expected experimental endpoint standard, 100% of the treatment group 2 reached the expected experimental endpoint standard, 0% of the control group 4 reached the expected experimental endpoint standard, 50% of the control group 5 reached the expected experimental endpoint standard, and 0% of the control group 6 reached the expected experimental endpoint standard.

[0028] Example 3

[0029] Patient Guo Moumou, who is recovering from hemiplegia caused by cerebral infarction, was hospitalized in the Department of Neurology, Datong Second People's Hospital. Initial diagnosis medical records: Examination items Ultrasound computer graphic report: The origin of the right subclavian artery is unclear, the intima-media thickening of the common carotid artery, internal carotid artery, and external carotid artery at the beginning of both sides, the inner wall is not smooth, and multiple masses can be seen on the wall. The larger one on the right is located at the bifurcation of the common carotid artery and is highly echogenic, with a size of about 9.1x26m, and the larger one on the left is located at the beginning of the external carotid artery, with a size of about 16.4x40mm. The local lumen is narrowed, and the diameter stenosis rate is about 62%. The wall of the starting section of the left internal carotid artery is focally thickened, and a low echo spot can be seen, with a size of about 15.1x28mm. The lumen is narrowed at this location, and the diameter stenosis is 65%. The low echo spot in the middle section of the left internal carotid artery is about 19.0x3.0cm.

[0030] Take 6 pills of the pharmaceutical composition prepared by the method described in Example 1, apply them to the patient's acupoints Fengfu, Fengchi, Naohu, Yuzhen, Naokong, and Tianzhu respectively, fix them with medical sanitary adhesive tape, and remove the adhesive tape after 24-36 hours (it varies from person to person, but the time is controlled between 24-36 hours); simply clean the vesicle endotoxin; use vacuum cups to cupping at the above acupoints to clean the blocked materials in the pipeline, and the extracted materials show serum-like substances, yellow jelly-like substances, and brown clot-like substances; medical Cupping is cleaned with sanitary disinfection; acupuncture points (wounds) are applied instead of the above-mentioned drug patch of the present invention. Only medical cotton cloth used to prevent wound scabs can be used to paste the wounds, so as to prevent the pipeline or channel from being blocked and affecting detoxification; the doctor advises to drink more water and eat a light diet; detoxification is performed once every morning according to the above-mentioned vacuum cupping; the detoxification opening gradually shrinks, and itching occurs locally (indicating that toxins are being discharged). After the toxins are discharged, the itching symptoms disappear by themselves; finally, the wound surface returns to normal skin after the toxins are discharged. A total of one application and eight cuppings. The specific clinical symptoms and therapeutic effects of the treatment are shown in Table 1.

[0031] Table 1 Specific clinical symptoms and therapeutic effects of eight cupping treatments in one application.

[0032] Clinical stage Clinical treatment records Clinical manifestations of patients 1 [Extracted substances]: serum-like substances, yellow jelly-like substances, brown clot-like substances [Patient experience]: no special feeling when applying, slight pain when cupping [Symptoms at acupoints]: slightly red, small black spots Unable to walk normally, right arm feels cold, weak, and numb 2 [Extracted substances]: serum-like substances, yellow jelly-like substances, brown clot-like substances [Patient experience]: obvious pain during cupping [Symptoms at acupoints]: wound with a diameter of about 2 cm, redness and swelling around Unable to walk normally but with feeling of retreat, right arm has less cold feeling but still weak, numbness slightly reduced 3 [Extracted substances]: serum-like substances, yellow jelly-like substances, brown clot-like substances [Patient experience]: intense pain during cupping [Symptoms at acupoints]: wound with a diameter of about 4 cm, with obvious redness and swelling around it Unable to walk normally but leg sensation is clear and flexion and extension are strong in bed, the cold feeling in the right arm continues to decrease and become strong, and the numbness has basically disappeared 4 [Extracted objects]: blood, brown clot-like substances, white colloid [Patient experience]: intense pain during cupping, accompanied by itching [Symptoms at acupoints]: There is a wound with a diameter of about 3cm, the surrounding redness and swelling have been reduced, and the wound has begun to scab Can walk normally with the help of external force, the coldness and numbness in the right arm disappear 5 [Extracted substances]: Blood, a small amount of dark brown clotted blood, and a slightly increased amount of white colloid [Feelings of the patient]: The patient felt extremely itchy. After disinfection, the scab on the wound was peeled off. After cupping to extract the poison, the itching disappeared [Symptoms at the acupoints]: There was a wound with a diameter of about 2cm. The scab at the cupping site was black, and the redness and swelling around the scab were significantly reduced I can walk normally with the help of external force, the cold feeling in my right arm has completely disappeared, and the numbness has completely disappeared 6 [Extracted substances]: Blood, a small amount of dark brown clotted blood, and white colloid, the same as last time [Feelings of the patient]: The patient felt extremely itchy. After disinfection, the scab on the wound was peeled off, and the itching disappeared after the cupping to extract the poison [Symptoms at the acupoints]: The "wound" was reduced and the surrounding redness and swelling basically disappeared Can basically walk normally, right arm symptoms completely disappeared, can carry light objects 7 [Extracted material]: A very small amount of dark brown clotted blood and white colloid material was significantly reduced [Feelings of the patient]: The patient felt extremely itchy. After disinfection, the scab on the wound was peeled off. After cupping to extract the poison, the itching disappeared [Symptoms at the acupoints]: The "wound" continued to shrink, and the surrounding redness and swelling disappeared Can walk normally, right arm symptoms completely disappeared, can lift heavy objects 8 [Extracted objects]: Except for the initial reduction of water vapor and bright red blood, there are no white, black, or brown extracted objects mentioned above [Patient experience]: Slight pain during cupping [Symptoms at acupoints]: Although the "wound" is visible, it is not obvious, and the surrounding redness and swelling have completely disappeared Just like a normal person, he can walk up the stairs and carry buckets normally. .

[0033] On the 7th day after eight cupping treatments, a follow-up examination was conducted, and the diagnostic report showed: CDFI: blood flow was good, and no atherosclerotic plaques were found in the right vertebral artery and bilateral carotid arteries. PW: normal spectrum. The bilateral vertebral arteries had normal courses, normal inner diameters, thin walls, and no echoes in the lumen.

[0034] The present invention adopts the highly efficient concentrated quantum technology of pure Chinese medicine preparations, combined with the clever compatibility of the five elements of Chinese medicine, adopts one prescription for one person, and the treatment goal is to help patients stop taking western medicine, injections, and surgery, and it is purely for external use, without taking any medicine orally, and the target cure rate of the disease caused by blood stasis is 99.5%. It integrates the six traditional treatment methods of Chinese medicine, namely "drugs + acupoints + plastering + foaming + circular cupping + circular bloodletting" detoxification process integrated therapy, until the natural scab heals to achieve the effect of removing blood stasis, detoxifying, and promoting blood circulation.

[0035] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein with equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the scope of protection of the claims of the present invention.

Claims

1. A sedative and detoxifying drug composition, characterized in that: The pharmaceutical composition is prepared from the following raw materials in parts by weight: 79-100 parts of a foaming component, 6-10 parts of a blood circulation and blood stasis removing component, 4-10 parts of a pain relieving component, 1-5 parts of a heat clearing and detoxifying component, and 1-5 parts of a meridian guiding component.

2. The pharmaceutical composition according to claim 1, characterized in that The foaming component is white mustard seeds, the blood circulation and blood stasis removing component is Panax notoginseng or Chuanxiong, the analgesic component is Corydalis yanhusuo, the heat clearing and detoxifying component is Scutellaria baicalensis, and the meridian guiding component is Gleditsia sinensis or Angelica dahurica.

3. The pharmaceutical composition according to claim 2, characterized in that 80 parts of white mustard seeds, 8 parts of Panax notoginseng, 6 parts of Corydalis yanhusuo, 3 parts of Scutellaria baicalensis, and 3 parts of Gleditsia sinensis.

4. The pharmaceutical composition according to claim 2, characterized in that 75 parts of white mustard seeds, 10 parts of chuanxiong, 5 parts of corydalis, 5 parts of scutellaria, 5 parts of angelica dahurica.

5. A Chinese medicine composition comprising the pharmaceutical composition according to any one of claims 1 to 4, characterized in that: According to the proportion of mass parts, each component of the pharmaceutical composition according to any one of claims 1 to 4 is taken separately, ground into fine powder, mixed evenly, and adjusted into a paste with mashed garlic and medical alcohol.

6. A Chinese medicine composition comprising the pharmaceutical composition according to any one of claims 1 to 4, characterized in that: The invention comprises medicinal powder and medicinal wine, wherein the medicinal powder is prepared by respectively taking the components in the pharmaceutical composition according to any one of claims 1 to 4 in proportion by mass, grinding them into fine powder, mixing them evenly, and putting them into a glass bottle in a cool place; the medicinal wine is prepared by proportioning Chinese herbal medicine and sorghum liquor with an alcohol content of more than 58 degrees, soaking them in a ceramic jar or a glass jar, and stirring them evenly; the Chinese herbal medicine is a mixture of licorice root, mint, calendula and polygonatum, and the licorice root, mint, calendula and polygonatum are in equal proportions by mass.

7. The Chinese medicine composition preparation according to any one of claims 5 to 6, characterized in that: The dosage form is tablet, pill, or pellet.

8. The method for preparing the preparation according to claim 7, characterized in that: (1) Prepare the medicinal powder, weigh 79-100 parts of the foaming component, 6-10 parts of the blood circulation and stasis removal component, 4-10 parts of the analgesic component, 1-5 parts of the heat-clearing and detoxifying component, and the meridian guiding component, grind them into fine powder, mix them evenly, put them into a glass bottle and place them in a cool place; (2) Prepare the medicinal wine, ① prepare a mixture of mashed garlic and medical alcohol, the mass ratio of the mashed garlic to the medical alcohol is 3-6:1; or ② prepare liquorice root, mint, calendula, polygonatum odoratum and 58% or more sorghum liquor in equal mass ratios, soak them in a ceramic jar or a glass jar, and stir them evenly, the proportion preparation means that the mass ratio of the Chinese herbal medicine to the sorghum liquor is 1-10:1; (3) Mix the medicinal powder with the medicinal wine, mix the medicinal powder of step (1) and the medicinal wine of step (2) in a mass ratio of 2-10:1, and the preparation is obtained.

9. Use of the pharmaceutical composition according to any one of claims 1 to 4 in the preparation of a medicament for treating diseases caused by qi stagnation and blood stasis.

10. The use according to claim 9, characterized in that Including stroke hemiplegia, prostate diseases, varicose veins, and tumors.