Animal bile long-term collecting device

Abstract

The invention relates to an animal bile long-term collecting device, and belongs to the field of animal bile extraction.The animal bile long-term collecting device comprises a dosing bin and a connecting pipe, the dosing bin comprises a bin body and a needle threading rubber plate, a needle threading opening is formed in the bin body, the needle threading rubber plate is fixedly connected to the bin body and seals the needle threading opening, two pipe joints are arranged on the bin body, and the connecting pipe is connected with the connecting pipe. The number of the connecting pipes is two, one end of each connecting pipe is correspondingly connected with one pipe connector, the end, away from the bin body, of one connecting pipe is connected with the common bile duct, and the end, away from the bin body, of the other connecting pipe is connected with the duodenum. The device is simple in structure, the using method is more convenient to operate compared with a traditional operation method, the service cycle is long, animal postoperative recovery is fast, and the infection risk is lower.

Description

Technical Field

[0001] The present application relates to the field of animal bile extraction, and in particular to a long-term animal bile collection device. Background Art

[0002] In drug experiments, studying changes in bile composition to evaluate the effects on drug absorption, distribution, metabolism and excretion is of great significance for the development of new drugs and the optimization of existing drugs. In addition, bile collection can also be used to study the functions of bile acids, bile pigments and other components, as well as their role in the digestive process. The liver metabolism and bile excretion of large animals are similar to those of humans, and are an indispensable part of drug experiments.

[0003] In the related art, bile extraction from living animals is done by direct bile duct cannulation, which requires the creation of a fistula on the living body to drain the bile out of the body. This poses a high risk of infection and the animal usage cycle is short, making it difficult to meet experimental requirements. Summary of the invention

[0004] In order to improve the above problems, the present application provides a long-term collection device for animal bile.

[0005] The present application provides a long-term animal bile collection device using the following technical solution: A long-term animal bile collection device comprises a dosing bin and a connecting tube, wherein the dosing bin comprises a bin body and a needle threading rubber plate, wherein the bin body is provided with a needle threading port, the needle threading rubber plate is fixedly connected to the bin body and closes the needle threading port, the bin body is provided with two pipe joints, and the connecting tubes have two ends, one end of a single connecting tube is correspondingly connected to a pipe joint, wherein one end of the connecting tube away from the bin body is connected to the common bile duct, and the other end of the connecting tube away from the bin body is connected to the duodenum.

[0006] By adopting the above technical solution, the dosing chamber and the connecting tube are both installed in the animal's body, and the bile flowing out of the common bile duct flows through the dosing chamber through the connecting tube and then flows to the duodenum. When bile needs to be collected, the liquid in the dosing chamber can be extracted and collected by inserting a needle into the needle port. Compared with the traditional method, the device has a simple structure, is easy to operate, and the animal recovers quickly after surgery with a lower risk of infection.

[0007] Preferably, a one-way valve is provided on the connecting tube, and the one-way valve allows the liquid in the connecting tube to flow from the common bile duct through the medication chamber to the duodenum.

[0008] By adopting the above technical solution, the one-way valve makes the bile flow in the liquid passage formed by the connecting tube and the medication chamber more stable.

[0009] Preferably, it also includes a collecting tube, one end of which is connected to a collecting needle, and the other end is provided with a negative pressure drainage ball, and the collecting needle is used to pass through the needle-threading rubber plate.

[0010] By adopting the above technical solution, the collection needle is inserted into the needle hole, and the needle end is located in the chamber body. The bile liquid inside can be sucked out by operating the negative pressure drainage ball, thereby achieving the operational purpose of bile collection.

[0011] Preferably, a filter assembly is provided in the bin body, and the filter assembly includes a filter bin and a flow control rotor. The filter bin is fixedly connected to the inner wall of the bin body. Along the circumference of the dosing bin, one end of the filter bin is open, and a filter plate is fixedly provided at the other end. The flow control rotor is located in the bin body and rotates. When the flow control rotor rotates, the liquid flow direction at the filter bin is from the open end to the end of the filter plate.

[0012] By adopting the above technical solution, the filter assembly is used to preliminarily separate bile sediments in the bile in the chamber. When the bile flows through the filter chamber, the sediments therein are intercepted by the filter plate and remain in the filter chamber, and are not easily collected by the collection needle.

[0013] Preferably, the flow control rotor is a centrifugal paddle, which is coaxially rotatably connected to the warehouse body, and the filter assembly includes a one-way bearing, a control gear, a control rack and a reciprocating spring. The control gear is coaxially rotatably connected to the warehouse body, and the control gear and the rotating shaft of the centrifugal paddle are coaxially connected through a one-way bearing. The control rack is meshed with the control gear, and the control rack is slidably connected to the warehouse body. One end of the reciprocating spring is connected to the warehouse body, and the other end is connected to the control rack. One end of the control rack is located outside the warehouse body.

[0014] By adopting the above technical solution, thrust is repeatedly applied to the control rack, and under the action of the reciprocating spring, the control rack moves back and forth, the control gear rotates bidirectionally repeatedly, and the centrifugal paddle rotates unidirectionally through the one-way bearing.

[0015] Preferably, a check plate is provided at one open end of the filter bin, the check plate is hinged to the filter bin, a torsion spring is provided on the hinge shaft, and in a natural state, the check plate blocks the opening of the filter bin, and when the centrifugal paddle rotates, the check plate flips into the filter bin.

[0016] By adopting the above technical solution, the presence of the check plate allows the liquid to enter smoothly, while preventing the sediment entering the filter chamber from easily overflowing from the filter chamber.

[0017] Preferably, a fixed needle assembly is provided in the warehouse body, and the fixed needle assembly includes a first clamping plate, a second clamping plate and an operator, the first clamping plate is fixedly connected to the warehouse body, the plate surface of the first clamping plate is perpendicular to the axis of the warehouse body, a plurality of first through holes are provided on the first clamping plate, the first clamping plate faces the side of the needle threading port and a guide slope is provided between adjacent first through holes, the second clamping plate is located on the side of the first clamping plate away from the needle threading rubber plate, the second clamping plate is slidably connected to the warehouse body, a plurality of second through holes are provided on the second clamping plate, the number of the second through holes is the same as the number of the first through holes, the collecting needle passes through the first through hole and the second through hole in sequence, the operator is used to control the movement of the second clamping plate, and the moving direction of the second clamping plate is parallel to the plate surface.

[0018] By adopting the above technical solution, when the collecting needle passes through the needle-piercing rubber plate, the second clamping plate needs to be in a position where the second through hole and the first through hole are interconnected, and the needle tip of the solid part either directly passes through the first through hole and the second through hole, or contacts the slope of the guide slope and slides into the first through hole and the second through hole, and then the second clamping plate is moved, causing the passage space formed by the first through hole and the second through hole to become narrower, and finally one side hole wall of the first through hole and one side hole wall of the second through hole respectively abut against the opposite sides of the solid part to clamp the collecting needle, thereby improving the state stability of the collecting needle relative to the bin body during the bile extraction process.

[0019] Preferably, the operator is a rebounder, which is fixedly connected to the warehouse body, and the button of the rebounder is located outside the warehouse body. The moving direction of the push block of the rebounder is consistent with the moving direction of the second clamping plate. A residual spring is connected between the push block of the rebounder and the second clamping plate. In a natural state, the rebounder keeps the second clamping plate stationary in two positions, in one position, the second through hole and the first through hole are correspondingly connected, and in the other position, the second clamping plate blocks the first through hole.

[0020] Preferably, the fixed needle assembly also includes an anvil plate, which is located on the side of the second clamping plate away from the first clamping plate, and the inner wall of the chamber body is provided with a mounting ring groove, the edge of the anvil plate is located in the mounting ring groove, and the bottom of the mounting ring groove is fixedly connected with a hollow rubber strip, and the hollow rubber strip abuts against the edge of the anvil plate.

[0021] By adopting the above technical solution, the end of the collecting needle is stuck on the anvil. Since the anvil has a movable space relative to the warehouse body, when the collecting needle is subjected to the abutment force of the second clamping plate and has a tendency to move, the anvil will also move accordingly, thereby reducing the bending deformation damage of the collecting needle.

[0022] Preferably, the collecting needle comprises a solid part and a hollow part which are coaxially integrally formed with each other, the solid part is located at one end of the hollow part, the end of the hollow part away from the solid part is connected to the collecting tube, the side wall of the hollow part is provided with a liquid hole, and the liquid hole is located on the side of the first clamping plate away from the second clamping plate; the side wall of the solid part is fixedly connected with a stop edge, the length direction of the stop edge is the circumference of the collecting needle, and the stop edge is located on the side of the first clamping plate or the second clamping plate away from the needle threading rubber plate.

[0023] By adopting the above technical solution, the collecting needle is not easily pulled out from the medication chamber without operating the rebounder to reset the second clamping plate, thereby further improving the state stability of the collecting needle during the long-term bile collection process.

[0024] In summary, the present application includes at least one of the following beneficial technical effects: 1. Through the setting of the dosing chamber and the connecting tube, both the dosing chamber and the connecting tube are installed in the animal body, and the bile flowing out of the common bile duct flows through the dosing chamber through the connecting tube and then flows to the duodenum. When bile needs to be collected, the liquid in the dosing chamber can be extracted and collected by inserting a needle into the needle hole. Compared with the traditional method, this device has a simple structure, is easy to operate, and the animal recovers quickly after surgery with a lower risk of infection; 2. Through the setting of the fixed needle assembly, when the collecting needle is inserted into the bin body, the front section of the collecting needle passes through the first clamping plate and the second clamping plate, and then the second clamping plate moves relative to the first clamping plate, and finally the first clamping plate and the second clamping plate respectively abut against the opposite side walls of the solid part through the hole wall of the first through hole and the hole wall of the second through hole, and at the same time, the first clamping plate or the second clamping plate forms a stop limit for the stop edge, and the collecting needle cannot be easily withdrawn from the bin body, thereby improving the stability of the collecting needle during the bile collection process. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 It is a schematic diagram of the overall structure of the long-term animal bile collection device in Example 1 of the present application.

[0026] Figure 2 It is a schematic diagram used to illustrate the internal structure of the medication chamber in Example 2 of the present application.

[0027] Figure 3 It is a schematic cross-sectional view of the structure of the filter assembly used to illustrate the second embodiment of the present application.

[0028] Figure 4 It is a schematic cross-sectional view of the structure of the fixed needle assembly in the second embodiment of the present application.

[0029] Figure 5 It is a schematic cross-sectional view of the structure used to illustrate the clamping of the collecting needle by the fixed needle assembly in the second embodiment of the present application.

[0030] Description of the reference numerals: 1. medicine chamber; 11. chamber body; 111. control hole; 112. mounting ring groove; 12. needle hole; 13. needle rubber plate; 14. pipe joint; 2. connecting pipe; 21. one-way valve; 3. collecting assembly; 31. collecting tube; 32. collecting needle; 321. hollow part; 322. solid part; 323. liquid hole; 324. stop edge; 33. negative pressure drainage ball; 4. filter assembly; 41. flow control Rotor; 42, filter chamber; 421, filter plate; 422, check plate; 43, control gear; 44, control rack; 45, reciprocating spring; 46, one-way bearing; 47, isolation soft film; 5, fixed needle assembly; 51, first clamping plate; 511, first through hole; 512, guide slope; 52, second clamping plate; 521, second through hole; 53, operator; 531, residual spring; 54, anvil; 55, hollow rubber strip. DETAILED DESCRIPTION

[0031] The following is combined with Figure 1-5 This application is described in further detail.

[0032] Embodiment 1: The present application embodiment discloses a long-term collection device for animal bile, such as Figure 1 As shown, it includes a dosing chamber 1, a connecting tube 2 and a collecting component 3; the connecting tube 2 is used to introduce the bile in the common bile duct into the dosing chamber 1 and continue to lead it to the duodenum, and the collecting component 3 is used to extract and collect the bile in the dosing chamber 1.

[0033] like Figure 1 As shown, the medication warehouse 1 includes a warehouse body 11 and a needle-threading rubber plate 13. The warehouse body 11 is truncated, and a needle-threading port 12 is opened on one end face. The needle-threading rubber plate 13 is fixedly connected to the warehouse body 11 and closes the needle-threading port 12. Two pipe joints 14 are fixedly arranged on the warehouse body 11. The connecting pipes 2 are silicone rubber hoses, and there are two of them. One end of a single connecting pipe 2 is connected to a pipe joint 14 correspondingly; the warehouse body 11 and the connecting pipes 2 will be built under the skin of a living animal, and one end of one connecting pipe 2 away from the warehouse body 11 will be connected to the common bile duct, and the other end of the connecting pipe 2 away from the warehouse body 11 will be connected to the duodenum. A one-way valve 21 is fixedly connected to the middle part of each connecting pipe 2. The one-way valve 21 is a silicone rubber one-way valve without a spring. The one-way valve 21 allows the liquid in the connecting pipe 2 to flow in the direction from the common bile duct through the medication warehouse 1 to the duodenum, reducing the probability of bile reflux.

[0034] like Figure 1As shown, the collection assembly 3 includes a collection tube 31, a collection needle 32 and a negative pressure drainage ball 33. The collection needle 32 is fixedly connected to one end of the collection tube 31, and the negative pressure drainage ball 33 is connected to the other end of the collection tube 31. After the collection needle 32 passes through the needle-piercing rubber plate 13, the end thereof away from the collection tube 31 is inserted into the bin body 11 to contact the bile inside the bin body 11.

[0035] The surgical procedure is: 1. Prepare a beagle dog that has been fasted for 8 hours, disinfect and shave the hair and prepare the skin of the animal in the middle abdomen and right side of the abdomen; 2. After the animal is fully anesthetized, a surgical access is made along the midline of the abdomen 3 cm below the xiphoid cartilage. The surgical access is about 10 cm. The abdominal cavity is opened to find the common bile duct and separate it. 3. Make a small incision on the common bile duct, insert the connecting tube 2, tie and fix the connecting tube 2 on the common bile duct, and extend the tube outside the body; 4. Insert another connecting tube 2 into the duodenum and fix the tube, and extend the tube outside the body; 5. After closing the abdominal surgical passage muscles, lead out two connecting tubes 2 at the front and rear ends of the surgical passage respectively; open the skin on the left side of the abdomen parallel to the surgical passage (about 15 cm apart), and fix the medication chamber 1 to the muscles at this position; 6. Connect and fix the pipe heads of the two connecting pipes 2 to the two pipe joints 14 on the medication chamber 1 respectively; 7. After the pipeline is fixed, the skin at the surgical access is closed, and the position of the one-way valve 21 is fixed with a non-absorbable suture. All parts of the connecting tube 2 are buried under the animal's skin; 8. The postoperative maintenance period is about seven days. Antibiotics and other antibacterial, anti-inflammatory and analgesic treatments can be used. The sutures at the closed part are removed according to the wound recovery status, and the one-way valve 21 fixing line is not removed. During the maintenance period, bile samples can be checked through the external puncture drug delivery port, and physiological saline can be injected through the external puncture drug delivery port to flush the duodenum.

[0036] When collecting bile, the living animal wears a special vest for bile collection (not shown in the figure), the negative pressure drainage ball 33 is fixed in the pocket of the vest, the collection needle 32 is inserted into the dosing chamber 1, and the negative pressure drainage ball 33 is used to guide the bile in the dosing chamber 1 into the pocket.

[0037] Embodiment 2: like Figure 2 and 3As shown, on the basis of the first embodiment, a filter assembly 4 is further provided in the bin body 11, and the filter assembly 4 is used for preliminarily separating bile sediments in the bile in the bin body 11. The filter assembly 4 includes a filter bin 42 and a flow control rotor 41. The filter bin 42 is fixedly connected to the inner wall of the bin body 11. Along the circumference of the medication bin 1, one end of the filter bin 42 is open, and a filter plate 421 is fixedly provided at the other end. The small openings on the filter plate 421 connect the inside and outside of the filter bin 42. The flow control rotor 41 is located in the bin body 11 and rotates, and the axis of rotation coincides with the axis of the bin body 11; the flow control rotor 41 is a centrifugal paddle, which is coaxially connected to the bin body 11 for rotation, and the centrifugal paddle includes a rotating shaft and three straight blades, and the plate surface of the blade is parallel to the axis of the centrifugal paddle. The filter assembly 4 also includes a one-way bearing 46, a control gear 43, a control rack 44 and a reciprocating spring 45 for making the centrifugal paddle rotate in one direction. The control gear 43 and the bin body 11 are coaxially connected for rotation. The control gear 43 and the rotating shaft of the centrifugal paddle are coaxially connected through the one-way bearing 46. The control rack 44 and the control gear 43 are meshed. The control rack 44 and the bin body 11 are slidingly connected, and the sliding direction is perpendicular to the rotating shaft of the centrifugal paddle, that is, the control rack 44 slides in both directions, and the control gear 43 rotates in both directions. The existence of the one-way bearing 46 only allows the centrifugal paddle to rotate in one direction; when the centrifugal paddle rotates, it drives the liquid in the bin body 11 to rotate, and the liquid flow direction at the filter bin 42 is from the open end to the end of the filter plate 421.

[0038] like Figure 2 and 3 As shown, under the centrifugal action, the sediment in the bile liquid has a probability to enter the filter chamber 42 from the opening of the filter chamber 42, and then the liquid continues to move through the filter plate 421, and the sediment is intercepted by the filter plate 421. In order to reduce the probability of the sediment entering the filter chamber 42 escaping from the chamber body 11, a check plate 422 is provided at one end of the opening of the filter chamber 42, and the check plate 422 is hinged to the filter chamber 42, and a torsion spring (not shown in the figure) is provided on the hinge shaft; the check plate 422 cannot be turned out of the filter chamber 42, and in a natural state, the check plate 422 blocks the opening of the filter chamber 42. When the centrifugal paddle rotates, the impact force of the fluid on the check plate 422 can make it turn into the filter chamber 42, and the opening of the filter chamber 42 is opened, and the sediment can enter relatively smoothly. The existence of the check plate 422 prevents the sediment entering the filter chamber 42 from easily overflowing from the filter chamber 42. A control hole 111 is opened on the bin body 11 for the control rack 44 to pass through, and an isolation soft membrane 47 is fixedly connected to the hole wall of the control hole 111. The isolation soft membrane 47 abuts against the end of the control rack 44 on one side facing the inner cavity of the bin body 11. The isolation soft membrane 47 improves the isolation between the inside and outside of the bin body 11 and reduces the contact between the filter component 4 and the tissue inside the animal body.

[0039] like Figure 2 and 4As shown, a fixed needle assembly 5 is also provided in the warehouse body 11, and the fixed needle assembly 5 is located between the centrifugal paddle and the control gear 43. The fixed needle assembly 5 includes a first clamping plate 51, a second clamping plate 52, an anvil 54 and an operator 53. The first clamping plate 51 is fixedly connected to the warehouse body 11, and a plurality of first through holes 511 are provided thereon. The first clamping plate 51 faces the side of the needle threading port 12 and a guide slope 512 is provided between each two adjacent first through holes 511. The second clamping plate 52 is located on the side of the first clamping plate 51 away from the needle threading rubber plate 13. The plate surfaces of the first clamping plate 51 and the second clamping plate 52 are perpendicular to the axis of the warehouse body 11. The second clamping plate 52 is slidably connected to the warehouse body 11, and the sliding direction is perpendicular to the axis of the warehouse body 11. The operator 53 is used to control the sliding of the second clamping plate 52; the second clamping plate 52 is provided with a plurality of second through holes 521, and the number of the second through holes 521 and the first through holes 511 are consistent and one-to-one corresponding. The first through hole 511 and the second through hole 521 are both in the shape of an elongated rectangle, and the moving direction of the second clamping plate 52 is perpendicular to the shape length direction of the second through hole 521. The anvil 54 is located on the side of the second clamping plate 52 away from the first clamping plate 51, and the plate surface of the anvil 54 is parallel to the plate surface of the first clamping plate 51; the inner wall of the warehouse body 11 is provided with a mounting ring groove 112, and the edge of the anvil 54 is located in the mounting ring groove 112, and the bottom of the mounting ring groove 112 is fixedly connected with a hollow rubber strip 55, and the hollow rubber strip 55 abuts against the edge of the anvil 54, and the elasticity and sealing of the hollow rubber strip 55 are controlled, so that the anvil 54 has a certain amount of lateral movement.

[0040] like Figure 4 and 5 As shown, the operator 53 is a rebounder, which is fixedly connected to the bin body 11, the button of the rebounder is located outside the bin body 11, the moving direction of the push block of the rebounder is consistent with the moving direction of the second clamping plate 52, and a residual spring 531 is connected between the push block of the rebounder and the second clamping plate 52. In a natural state, the rebounder keeps the second clamping plate 52 stationary at two positions, one of which is that the second through hole 521 and the first through hole 511 are flush and connected, and the second clamping plate 52 blocks the first through hole 511 at the other position.

[0041] like Figure 4 and 5As shown, the collecting needle 32 includes a solid part 322 and a hollow part 321 which are coaxially formed integrally with each other. The solid part 322 is located at one end of the hollow part 321. The end of the hollow part 321 away from the solid part 322 is connected to the collecting tube 31. The needle tip is located in the solid part 322. The side wall of the hollow part 321 is provided with a liquid hole 323. The liquid hole 323 connects the inner and outer spaces of the hollow part 321. When the collecting needle 32 passes through the needle-piercing rubber plate 13, the second clamping plate 52 needs to be in a position where the second through hole 521 and the first through hole 511 are connected to each other. The needle tip of the solid part 322 either directly passes through the first through hole 511 and the second through hole 521, or contacts the slope of the guide slope 512 and slides into the first through hole 511 and the second through hole 521, and finally pierces the anvil 54. The second clamping plate 52 is moved by operating the rebounder in the direction of the width of the second through hole 521, thereby narrowing the passage space formed by the first through hole 511 and the second through hole 521. Finally, one side wall of the first through hole 511 and one side wall of the second through hole 521 abut against the opposite sides of the solid portion 322, respectively, to clamp the collecting needle 32. The side wall of the solid portion 322 is fixedly connected with a backstop edge 324, and the length direction of the backstop edge 324 is the circumferential direction of the collecting needle 32. When the needle tip of the collecting needle 32 is pierced on the anvil 54, the backstop edge 324 is located on the side of the first clamping plate 51 or the second clamping plate 52 away from the needle threading rubber plate 13, and the liquid hole 323 is located on the side of the first clamping plate 51 away from the second clamping plate 52; without operating the rebounder to reset the second clamping plate 52, the collecting needle 32 is not easy to be pulled out from the dosing chamber 1, thereby improving the state stability of the collecting needle 32 during the long-term collection of bile.

[0042] like Figure 3 , 4 As shown in Figure 5, in this embodiment, the control gear 43, the control rack 44 and the reciprocating spring 45 are all embedded in the bottom wall thickness of the chamber body 11; the rotating shaft of the centrifugal paddle passes through the anvil plate 54, the second clamping plate 52 and the first clamping plate 51 in sequence, that is, the center positions of the two clamping plates and the anvil plate 54 are provided with through holes for the rotating shaft of the centrifugal paddle to pass through. The through hole size on the anvil plate 54 and the second clamping plate 52 is larger than the radial size of the rotating shaft of the centrifugal paddle, so as to leave space for the lateral movement of the anvil plate 54 and the second clamping plate 52.

[0043] The above are all preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. Therefore, any equivalent changes made according to the structure, shape, and principle of the present application should be included in the protection scope of the present application.

Claims

1. A long-term collection device for animal bile, characterized in that: The invention comprises a medication chamber (1) and a connecting tube (2), wherein the medication chamber (1) comprises a chamber body (11) and a needle insertion rubber plate (13), wherein the chamber body (11) is provided with a needle insertion port (12), wherein the needle insertion rubber plate (13) is fixedly connected to the chamber body (11) and closes the needle insertion port (12), wherein the chamber body (11) is provided with two pipe joints (14), wherein the connecting tubes (2) have two ends, wherein one end of a single connecting tube (2) is connected to a corresponding pipe joint (14), wherein one end of the connecting tube (2) away from the chamber body (11) is connected to the common bile duct, and the other end of the connecting tube (2) away from the chamber body (11) is connected to the duodenum.

2. The long-term animal bile collection device according to claim 1, characterized in that: The connecting tube (2) is provided with a one-way valve (21), and the one-way valve (21) allows the liquid in the connecting tube (2) to flow from the common bile duct through the medication chamber (1) to the duodenum.

3. The long-term animal bile collection device according to claim 1 or 2, characterized in that: It also comprises a collecting tube (31), one end of which is connected to a collecting needle (32), and the other end of which is provided with a negative pressure drainage ball (33), and the collecting needle (32) is used to pass through the needle-threading rubber plate (13).

4. The long-term animal bile collection device according to claim 3, characterized in that: A filter assembly (4) is provided in the bin body (11), and the filter assembly (4) comprises a filter bin (42) and a flow control rotor (41). The filter bin (42) is fixedly connected to the inner wall of the bin body (11). Along the circumference of the medication bin (1), one end of the filter bin (42) is open, and a filter plate (421) is fixedly provided at the other end. The flow control rotor (41) is located in the bin body (11) and rotates. When the flow control rotor (41) rotates, the liquid in the filter bin (42) flows from the open end to the end of the filter plate (421).

5. The long-term animal bile collection device according to claim 4, characterized in that: The flow control rotor (41) is a centrifugal paddle, and the centrifugal paddle is coaxially rotatably connected to the warehouse body (11). The filter assembly (4) comprises a one-way bearing (46), a control gear (43), a control rack (44) and a reciprocating spring (45). The control gear (43) is coaxially rotatably connected to the warehouse body (11). The control gear (43) and the rotating shaft of the centrifugal paddle are coaxially connected via the one-way bearing (46). The control rack (44) is meshed with the control gear (43). The control rack (44) is slidably connected to the warehouse body (11). One end of the reciprocating spring (45) is connected to the warehouse body (11), and the other end is connected to the control rack (44). One end of the control rack (44) is located outside the warehouse body (11).

6. The long-term animal bile collection device according to claim 4, characterized in that: A check plate (422) is provided at one open end of the filter chamber (42); the check plate (422) and the filter chamber (42) are hinged, and a torsion spring is provided on the hinge shaft; in a natural state, the check plate (422) blocks the open end of the filter chamber (42); when the centrifugal paddle rotates, the check plate (422) flips into the filter chamber (42).

7. The long-term animal bile collection device according to claim 3, characterized in that: The housing (11) is provided with a fixed needle assembly (5), and the fixed needle assembly (5) comprises a first clamping plate (51), a second clamping plate (52) and an operator (53); the first clamping plate (51) is fixedly connected to the housing (11); the plate surface of the first clamping plate (51) is perpendicular to the axis of the housing (11); a plurality of first through holes (511) are provided on the first clamping plate (51); a guide slope (512) is provided on one side of the first clamping plate (51) facing the needle threading port (12) and between adjacent first through holes (511); The holding plate (52) is located on the side of the first clamping plate (51) away from the needle-threading rubber plate (13), the second clamping plate (52) is slidably connected to the warehouse body (11), a plurality of second through holes (521) are opened on the second clamping plate (52), and the number of the second through holes (521) and the first through holes (511) are the same, the collecting needle (32) passes through the first through hole (511) and the second through hole (521) in sequence, and the operator (53) is used to control the movement of the second clamping plate (52), and the moving direction of the second clamping plate (52) is parallel to the plate surface.

8. The long-term animal bile collection device according to claim 7, characterized in that: The operator (53) is a rebounder, which is fixedly connected to the magazine body (11). The button of the rebounder is located outside the magazine body (11). The moving direction of the push block of the rebounder is consistent with the moving direction of the second clamping plate (52). A residual spring (531) is connected between the push block of the rebounder and the second clamping plate (52). In a natural state, the rebounder keeps the second clamping plate (52) stationary at two positions. In one position, the second through hole (521) and the first through hole (511) are correspondingly connected, and in the other position, the second clamping plate (52) blocks the first through hole (511).

9. The long-term animal bile collection device according to claim 8, characterized in that: The fixed needle assembly (5) also includes an anvil (54), which is located on the side of the second clamping plate (52) away from the first clamping plate (51), and the inner wall of the storage body (11) is provided with a mounting ring groove (112), the edge of the anvil (54) is located in the mounting ring groove (112), and the bottom of the mounting ring groove (112) is fixedly connected with a hollow rubber strip (55), and the hollow rubber strip (55) and the edge of the anvil (54) are in abutment.

10. The long-term animal bile collection device according to claim 8, characterized in that: The collecting needle (32) comprises a solid part (322) and a hollow part (321) which are coaxially integrally formed with each other, the solid part (322) is located at one end of the hollow part (321), the end of the hollow part (321) away from the solid part (322) is connected to the collecting tube (31), and a liquid passage hole (323) is provided on the side wall of the hollow part (321), and the liquid passage hole (323) is located on a side of the first clamping plate (51) away from the second clamping plate (52); The side wall of the solid portion (322) is fixedly connected with a back-stop edge (324), the length direction of the back-stop edge (324) is the circumferential direction of the collecting needle (32), and the back-stop edge (324) is located on the side of the first clamping plate (51) or the second clamping plate (52) away from the needle threading rubber plate (13).

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