A long-term collection device for animal bile

Abstract

This application relates to a device for long-term collection of animal bile, belonging to the field of animal bile extraction. It includes a drug administration chamber and a connecting tube. The drug administration chamber includes a chamber body and a needle-piercing rubber plate. A needle-piercing opening is formed on the chamber body. The needle-piercing rubber plate is fixedly connected to the chamber body and closes the needle-piercing opening. Two pipe connectors are provided on the chamber body. There are two connecting tubes. One end of a single connecting tube is correspondingly connected to one pipe connector. One end of one connecting tube away from the chamber body is connected to the common bile duct, and one end of the other connecting tube away from the chamber body is connected to the duodenum. The device of this application has a simple structure, the usage method is more convenient to operate compared with the traditional surgical method, has a long service life, the animals recover quickly after the operation, and the infection risk is lower.

Description

Technical Field

[0001] This application relates to the field of animal bile extraction, and particularly to a long-term animal bile collection device. Background Art

[0002] In drug experiments, studying the compositional changes of bile to evaluate its impact on drug absorption, distribution, metabolism, and excretion is of great significance for the development of new drugs and the optimization of existing drugs. In addition, bile collection can also be used to study the functions of components such as bile acids and bilirubin, as well as their roles in the digestive process. The liver metabolism and bile excretion of large animals are similar to those of humans, making them an indispensable part of drug experiments.

[0003] In related technologies, the method of extracting bile from live animals is direct collection through bile duct intubation, which requires creating a fistula on the live body for bile drainage to the outside. This has a relatively high infection risk and a short animal usage cycle, making it difficult to meet the experimental requirements. Summary of the Invention

[0004] To address the above problems, this application provides a long-term animal bile collection device.

[0005] The long-term animal bile collection device provided by this application adopts the following technical solutions:

[0006] A long-term animal bile collection device includes a drug administration chamber and a connecting tube. The drug administration chamber includes a chamber body and a needle-piercing rubber plate. A needle-piercing opening is provided on the chamber body, and the needle-piercing rubber plate is fixedly connected to the chamber body to close the needle-piercing opening. Two pipe connectors are provided on the chamber body. There are two connecting tubes. One end of a single connecting tube corresponds to and is connected to one pipe connector. One end of one connecting tube away from the chamber body is connected to the common bile duct, and one end of the other connecting tube away from the chamber body is connected to the duodenum.

[0007] By adopting the above technical solutions, the drug administration chamber and the connecting tube are both installed in the animal body. Bile flowing out from the common bile duct flows through the connecting tube, passes through the drug administration chamber, and then flows to the duodenum. When bile needs to be collected, the liquid in the drug administration chamber can be extracted and collected by inserting a syringe needle into the needle-piercing opening. Compared with the traditional method, the structure of this device is simple, the operation is convenient, the animal recovers quickly after surgery, and the infection risk is lower.

[0008] Preferably, a one-way valve is provided on the connecting tube, and the one-way valve allows the liquid flow direction in the connecting tube to be from the common bile duct through the drug administration chamber to the duodenum.

[0009] By adopting the above technical solutions, the one-way valve makes the bile flow direction in the liquid passage formed by the connecting tube and the drug administration chamber more stable.

[0010] Preferably, it further includes a collection tube. One end of the collection tube is connected with a collection needle, and the other end is provided with a negative pressure drainage ball. The collection needle is used to penetrate through the needle-piercing rubber plate.

[0011] By adopting the above technical solution, the collection needle is inserted into the needle-piercing opening, and the needle tip is located inside the chamber. Operating the negative pressure drainage ball can suck out the bile liquid inside it, achieving the operation purpose of bile collection.

[0012] Preferably, a filtering assembly is provided inside the chamber. The filtering assembly includes a filtering chamber and a flow control rotor. The filtering chamber is fixedly connected to the inner side wall of the chamber. Along the circumferential direction of the drug administration chamber, one end of the filtering chamber is an open end, and the other end is fixedly provided with a filter plate. The flow control rotor rotates inside the chamber. When the flow control rotor rotates, the liquid flow direction at the filtering chamber is from the open end to the filter plate end.

[0013] By adopting the above technical solution, the filtering assembly is used to preliminarily separate the bile precipitates in the bile inside the chamber. When the bile flows through the filtering chamber, the precipitates therein are intercepted by the filter plate and remain in the filtering chamber, and are not easily collected by the collection needle.

[0014] Preferably, the flow control rotor is a centrifugal paddle. The centrifugal paddle is coaxially rotatably connected to the chamber. The filtering assembly includes a one-way bearing, a control gear, a control rack, and a reciprocating spring. The control gear is coaxially rotatably connected to the chamber. The control gear and the rotating shaft of the centrifugal paddle are coaxially connected through the one-way bearing. The control rack meshes with the control gear. The control rack is slidably connected to the chamber. One end of the reciprocating spring is connected to the chamber, and the other end is connected to the control rack. One end of the control rack is located outside the chamber.

[0015] By adopting the above technical solution, repeatedly applying a thrust force to the control rack, under the action of the reciprocating spring, the control rack reciprocates, the control gear rotates bidirectionally and repeatedly, and the centrifugal paddle is controlled to rotate unidirectionally through the one-way bearing.

[0016] Preferably, a check valve plate is provided at the open end of the filtering chamber. The check valve plate is hinged to the filtering chamber, and a torsion spring is provided on the hinge shaft. In the natural state, the check valve plate seals the open end of the filtering chamber. When the centrifugal paddle rotates, the check valve plate flips into the filtering chamber.

[0017] By adopting the above technical solution, the presence of the check valve plate can allow the liquid to enter smoothly, and at the same time prevent the precipitates entering the filtering chamber from easily overflowing from the filtering chamber.

[0018] Preferably, a fixed needle assembly is provided in the warehouse body, and the fixed needle assembly includes a first clamping plate, a second clamping plate and an operator, the first clamping plate is fixedly connected to the warehouse body, the plate surface of the first clamping plate is perpendicular to the axis of the warehouse body, a plurality of first through holes are provided on the first clamping plate, the first clamping plate faces the side of the needle threading port and a guide slope is provided between adjacent first through holes, the second clamping plate is located on the side of the first clamping plate away from the needle threading rubber plate, the second clamping plate is slidably connected to the warehouse body, a plurality of second through holes are provided on the second clamping plate, the number of the second through holes is the same as the number of the first through holes, the collecting needle passes through the first through hole and the second through hole in sequence, the operator is used to control the movement of the second clamping plate, and the moving direction of the second clamping plate is parallel to the plate surface.

[0019] By adopting the above technical solution, when the collecting needle passes through the needle-piercing rubber plate, the second clamping plate needs to be in a position where the second through hole and the first through hole are interconnected, and the needle tip of the solid part either directly passes through the first through hole and the second through hole, or contacts the slope of the guide slope and slides into the first through hole and the second through hole, and then the second clamping plate is moved, causing the passage space formed by the first through hole and the second through hole to become narrower, and finally one side hole wall of the first through hole and one side hole wall of the second through hole respectively abut against the opposite sides of the solid part to clamp the collecting needle, thereby improving the state stability of the collecting needle relative to the bin body during the bile extraction process.

[0020] Preferably, the operator is a rebounder, which is fixedly connected to the warehouse body, and the button of the rebounder is located outside the warehouse body. The moving direction of the push block of the rebounder is consistent with the moving direction of the second clamping plate. A residual spring is connected between the push block of the rebounder and the second clamping plate. In a natural state, the rebounder keeps the second clamping plate stationary in two positions, in one position, the second through hole and the first through hole are correspondingly connected, and in the other position, the second clamping plate blocks the first through hole.

[0021] Preferably, the fixed needle assembly also includes an anvil plate, which is located on the side of the second clamping plate away from the first clamping plate, and the inner wall of the chamber body is provided with a mounting ring groove, the edge of the anvil plate is located in the mounting ring groove, and the bottom of the mounting ring groove is fixedly connected with a hollow rubber strip, and the hollow rubber strip abuts against the edge of the anvil plate.

[0022] By adopting the above technical solution, the end of the collecting needle is stuck on the anvil. Since the anvil has a movable space relative to the warehouse body, when the collecting needle is subjected to the abutment force of the second clamping plate and has a tendency to move, the anvil will also move accordingly, thereby reducing the bending deformation damage of the collecting needle.

[0023] Preferably, the collection needle includes a solid part and a hollow part that are integrally formed coaxially with each other. The solid part is located at one end of the hollow part. The end of the hollow part away from the solid part is communicated with the collection tube. A liquid passing hole is formed in the side wall of the hollow part, and the liquid passing hole is located on the side of the first clamping plate facing away from the second clamping plate. A backstop edge is fixedly connected to the side wall of the solid part, the length direction of the backstop edge is the circumferential direction of the collection needle, and the backstop edge is located on the side of the first clamping plate or the second clamping plate facing away from the needle-piercing rubber plate.

[0024] By adopting the above technical solution, without operating the rebounder to reset the second clamping plate, the collection needle is not easily pulled out from the drug administration chamber, thereby further improving the state stability of the collection needle during the long-term collection of bile.

[0025] To sum up, the present application includes at least one of the following beneficial technical effects:

[0026] 1. Through the arrangement of the drug administration chamber and the connecting tube, both the drug administration chamber and the connecting tube are installed in the animal body. The bile flowing out from the common bile duct flows through the connecting tube, passes through the drug administration chamber and then flows into the duodenum. When it is necessary to collect bile, the liquid in the drug administration chamber can be extracted and collected by inserting a syringe into the needle-piercing port. Compared with the traditional method, the structure of this device is simple, the operation is convenient, the animal recovers quickly after the operation, and the infection risk is lower.

[0027] 2. Through the arrangement of the needle fixing assembly, after the collection needle is inserted into the chamber body, the front section of the collection needle passes through the first clamping plate and the second clamping plate, and then the second clamping plate moves relative to the first clamping plate. Finally, the first clamping plate and the second clamping plate respectively abut against the opposite side walls of the solid part through the hole walls of the first through hole and the second through hole. At the same time, the first clamping plate or the second clamping plate forms a backstop limit for the backstop edge, and the collection needle cannot easily withdraw from the chamber body, improving the stability of the collection needle during the bile collection process. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 is a schematic diagram of the overall structure of the device for long-term collection of animal bile in Embodiment 1 of the present application.

[0029] Figure 2 is a schematic diagram of the internal structure of the drug administration chamber in Embodiment 2 of the present application.

[0030] Figure 3 is a schematic cross-sectional view of the structure of the filtering component in Embodiment 2 of the present application.

[0031] Figure 4 is a schematic cross-sectional view of the structure of the needle fixing component in Embodiment 2 of the present application.

[0032] Figure 5It is a schematic cross-sectional view of the structure when the needle-fixing component clamps the collecting needle in the second embodiment of the present application.

[0033] Explanation of reference numerals: 1. Administration chamber; 11. Chamber body; 111. Control hole; 112. Installation ring groove; 12. Needle-passing port; 13. Needle-passing rubber plate; 14. Pipe joint; 2. Connecting pipe; 21. Check valve; 3. Collection assembly; 31. Collection pipe; 32. Collection needle; 321. Hollow part; 322. Solid part; 323. Liquid-passing hole; 324. Anti-reverse edge; 33. Negative pressure drainage ball; 4. Filtration assembly; 41. Flow control rotor; 42. Filtration chamber; 421. Filter plate; 422. Check plate; 43. Control gear; 44. Control rack; 45. Reciprocating spring; 46. One-way bearing; 47. Isolation soft film; 5. Needle-fixing component; 51. First clamping plate; 511. First through hole; 512. Guide slope; 52. Second clamping plate; 521. Second through hole; 53. Operator; 531. Remaining spring; 54. Anvil; 55. Hollow rubber strip. Detailed implementation manners

[0034] The following further Figures 1-5 describes the present application in detail.

[0035] Embodiment 1:

[0036] The embodiment of the present application discloses an animal bile long-term collection device, as Figure 1 shown, including an administration chamber 1, a connecting pipe 2 and a collection assembly 3; the connecting pipe 2 is used to introduce the bile in the common bile duct into the administration chamber 1 and continue to lead it to the duodenum, and the collection assembly 3 is used to extract and collect the bile in the administration chamber 1.

[0037] As Figure 1 shown, the administration chamber 1 includes a chamber body 11 and a needle-passing rubber plate 13. The chamber body 11 is frustum-shaped, and a needle-passing port 12 is opened on one end surface thereof. The needle-passing rubber plate 13 is fixedly connected to the chamber body 11 and closes the needle-passing port 12. Two pipe joints 14 are fixedly arranged on the chamber body 11. The connecting pipe 2 is a silicone rubber hose, and the number is two. One end of a single connecting pipe 2 corresponds to and is connected to one pipe joint 14; the chamber body 11 and the connecting pipe 2 are placed under the skin of a living animal. One end of one connecting pipe 2 away from the chamber body 11 will be connected to the common bile duct, and the other end of the other connecting pipe 2 away from the chamber body 11 will be connected to the duodenum. A check valve 21 is fixedly connected to the middle of each connecting pipe 2. The check valve 21 is a silicone rubber springless one-way valve. The liquid flow direction allowed by the check valve 21 in the connecting pipe 2 is from the common bile duct through the administration chamber 1 to the duodenum, reducing the probability of bile reflux.

[0038] As Figure 1As shown in the figure, the collection assembly 3 includes a collection tube 31, a collection needle 32, and a negative pressure drainage ball 33. The collection needle 32 is fixedly connected to one end of the collection tube 31, and the negative pressure drainage ball 33 is connected to the other end of the collection tube 31. After the collection needle 32 passes through the needle-piercing rubber plate 13, the end away from the collection tube 31 is inserted into the chamber body 11 to contact the bile inside.

[0039] The surgical procedure is as follows:

[0040] 1. Prepare a beagle dog and fast it for 8 hours. Disinfect, shave, and prepare the skin of the mid-abdomen and the right abdomen of the animal.

[0041] 2. After the animal is fully anesthetized, make a surgical access along the midline of the abdomen 3 cm below the xiphoid cartilage. The surgical access is about 10 cm. Open the abdominal cavity to find the common bile duct and separate the common bile duct.

[0042] 3. Make a small incision on the common bile duct, insert the connecting tube 2, and ligate and fix the connecting tube 2 on the common bile duct, and extend the pipeline to the outside of the body.

[0043] 4. Insert another connecting tube 2 into the duodenum and fix the pipeline, and extend the pipeline to the outside of the body.

[0044] 5. After closing the muscle of the abdominal surgical access, lead out the tube heads of the two connecting tubes 2 at the front and rear ends of the surgical access respectively; open the skin on the left abdomen parallel to (with a spacing of about 15 cm) the surgical access, and fix the drug delivery chamber 1 to the muscle at this position.

[0045] 6. Docking and fixing the tube heads of the two connecting tubes 2 to the two tube connectors 14 on the drug delivery chamber 1 respectively.

[0046] 7. After fixing the pipeline, close the skin at the surgical access, use non-absorbable sutures to fix the position of the one-way valve 21, and bury all parts of the connecting tube 2 under the skin of the animal.

[0047] 8. Maintain for about seven days after the operation. Antibiotics and other drugs can be used for antibacterial, anti-inflammatory, and analgesic treatments. Sutures at the closure are removed according to the wound healing condition, and the fixing thread of the one-way valve 21 is not removed. During the maintenance period, bile samples can be examined through the external puncture drug delivery port, and saline can also be injected through the external puncture drug delivery port to flush the tube in the direction of the duodenum.

[0048] When collecting bile, the live animal wears a special vest for bile collection (not shown in the figure). The negative pressure drainage ball 33 is fixed at the pocket of the vest. Insert the collection needle 32 into the drug delivery chamber 1, and use the negative pressure drainage ball 33 to draw the bile in the drug delivery chamber 1 into the pocket.

[0049] Example Two:

[0050] As Figure 2 and 3As shown, on the basis of the first embodiment, a filtering assembly 4 is further provided in the bin body 11. The filtering assembly 4 is used to initially separate the bile precipitates in the bile in the bin body 11. The filtering assembly 4 includes a filtering bin 42 and a flow control rotor 41. The filtering bin 42 is fixedly connected to the inner side wall of the bin body 11. Along the circumferential direction of the administration bin 1, one end of the filtering bin 42 is open, and the other end is fixedly provided with a filter plate 421. The small openings on the filter plate 421 communicate the inside and outside of the filtering bin 42. The flow control rotor 41 rotates in the bin body 11, and the rotation axis coincides with the axis of the bin body 11; the flow control rotor 41 is a centrifugal paddle, and the centrifugal paddle is coaxially rotatably connected to the bin body 11. The centrifugal paddle includes a rotating shaft and three straight paddle blades, and the plate surface of the paddle blade is parallel to the axis of the centrifugal paddle. The filtering assembly 4 further includes a one-way bearing 46, a control gear 43, a control rack 44 and a reciprocating spring 45 for making the centrifugal paddle rotate in one direction. The control gear 43 is coaxially rotatably connected to the bin body 11, and the control gear 43 and the rotating shaft of the centrifugal paddle are coaxially connected through the one-way bearing 46. The control rack 44 meshes with the control gear 43, and the control rack 44 is slidably connected to the bin body 11, and the sliding direction is perpendicular to the rotating shaft of the centrifugal paddle, that is, the control rack 44 slides bidirectionally, and the control gear 43 rotates bidirectionally. The existence of the one-way bearing 46 only allows the centrifugal paddle to rotate in one direction; when the centrifugal paddle rotates, it drives the liquid in the bin body 11 to rotate, and the liquid flow direction at the filtering bin 42 is from the open end to the filter plate 421 end.

[0051] As Figure 2 and 3 shown, under the action of centrifugal force, there is a chance that the precipitates in the bile liquid enter the filtering bin 42 from the open end of the filtering bin 42, and then the liquid continues to move through the filter plate 421, and the precipitates are intercepted by the filter plate 421. In order to reduce the chance that the precipitates entering the filtering bin 42 escape from the bin body 11, a check valve plate 422 is provided at the open end of the filtering bin 42. The check valve plate 422 is hinged to the filtering bin 42, and a torsion spring (not shown in the figure) is provided on the hinge shaft; the check valve plate 422 cannot be turned out of the filtering bin 42. In the natural state, the check valve plate 422 blocks the open end of the filtering bin 42. When the centrifugal paddle rotates, the impact force of the fluid on the check valve plate 422 can make it turn into the filtering bin 42, and the open end of the filtering bin 42 is opened, and the precipitates can enter more smoothly. The existence of the check valve plate 422 makes the precipitates entering the filtering bin 42 not easily overflow from the filtering bin 42. A control hole 111 for the control rack 44 to pass through is opened on the bin body 11, and an isolation soft film 47 is fixedly connected to the hole wall of the control hole 111. The side of the isolation soft film 47 facing the inner cavity of the bin body 11 abuts against the end of the control rack 44. The isolation soft film 47 improves the isolation between the inside and outside of the bin body 11 and reduces the contact between the filtering assembly 4 and the tissues in the animal body.

[0052] As Figure 2 and 4As shown, a fixed needle assembly 5 is also provided in the warehouse body 11, and the fixed needle assembly 5 is located between the centrifugal paddle and the control gear 43. The fixed needle assembly 5 includes a first clamping plate 51, a second clamping plate 52, an anvil 54 and an operator 53. The first clamping plate 51 is fixedly connected to the warehouse body 11, and a plurality of first through holes 511 are provided thereon. The first clamping plate 51 faces the side of the needle threading port 12 and a guide slope 512 is provided between each two adjacent first through holes 511. The second clamping plate 52 is located on the side of the first clamping plate 51 away from the needle threading rubber plate 13. The plate surfaces of the first clamping plate 51 and the second clamping plate 52 are perpendicular to the axis of the warehouse body 11. The second clamping plate 52 is slidably connected to the warehouse body 11, and the sliding direction is perpendicular to the axis of the warehouse body 11. The operator 53 is used to control the sliding of the second clamping plate 52; the second clamping plate 52 is provided with a plurality of second through holes 521, and the number of the second through holes 521 and the first through holes 511 are consistent and one-to-one corresponding. The first through hole 511 and the second through hole 521 are both in the shape of an elongated rectangle, and the moving direction of the second clamping plate 52 is perpendicular to the shape length direction of the second through hole 521. The anvil 54 is located on the side of the second clamping plate 52 away from the first clamping plate 51, and the plate surface of the anvil 54 is parallel to the plate surface of the first clamping plate 51; the inner wall of the warehouse body 11 is provided with a mounting ring groove 112, and the edge of the anvil 54 is located in the mounting ring groove 112, and the bottom of the mounting ring groove 112 is fixedly connected with a hollow rubber strip 55, and the hollow rubber strip 55 abuts against the edge of the anvil 54, and the elasticity and sealing of the hollow rubber strip 55 are controlled, so that the anvil 54 has a certain amount of lateral movement.

[0053] like Figure 4 and 5 As shown, the operator 53 is a rebounder, which is fixedly connected to the bin body 11, the button of the rebounder is located outside the bin body 11, the moving direction of the push block of the rebounder is consistent with the moving direction of the second clamping plate 52, and a residual spring 531 is connected between the push block of the rebounder and the second clamping plate 52. In a natural state, the rebounder keeps the second clamping plate 52 stationary at two positions, one of which is that the second through hole 521 and the first through hole 511 are flush and connected, and the second clamping plate 52 blocks the first through hole 511 at the other position.

[0054] like Figure 4 and 5As shown in the figure, the collection needle 32 includes a solid part 322 and a hollow part 321 that are integrally formed coaxially with each other. The solid part 322 is located at one end of the hollow part 321. The end of the hollow part 321 away from the solid part 322 is communicated with the collection tube 31. The needle tip is located at the solid part 322. A liquid passing hole 323 is formed in the side wall of the hollow part 321, and the liquid passing hole 323 communicates the inner and outer spaces of the hollow part 321. When the collection needle 32 passes through the needle-piercing rubber plate 13, the second clamping plate 52 needs to be in the position where the second through hole 521 and the first through hole 511 communicate with each other. The needle tip of the solid part 322 either directly passes through the first through hole 511 and the second through hole 521, or contacts the slope of the guiding slope 512 and slides into the first through hole 511 and the second through hole 521, and finally pierces the chopping board 54. Operating the spring-back device makes the second clamping plate 52 move, and the moving direction is the width direction of the second through hole 521, thereby causing the passage space jointly formed by the first through hole 511 and the second through hole 521 to become narrower. Finally, one side hole wall of the first through hole 511 and one side hole wall of the second through hole 521 respectively abut against the opposite sides of the solid part 322, forming a clamp on the collection needle 32. A backstop edge 324 is fixedly connected to the side wall of the solid part 322. The length direction of the backstop edge 324 is the circumferential direction of the collection needle 32. When the needle tip of the collection needle 32 pierces the chopping board 54, the backstop edge 324 is located on the side of the first clamping plate 51 or the second clamping plate 52 away from the needle-piercing rubber plate 13, and the liquid passing hole 323 is located on the side of the first clamping plate 51 away from the second clamping plate 52; without operating the spring-back device to reset the second clamping plate 52, the collection needle 32 is not easily pulled out from the drug administration chamber 1, thereby improving the state stability of the collection needle 32 during the long-term collection of bile.

[0055] As Figure 3 , 4 As shown in FIGS. 4 and 5, in this embodiment, the control gear 43, the control rack 44, and the reciprocating spring 45 are all embedded in the bottom wall thickness of the chamber body 11; the rotating shaft of the centrifugal paddle sequentially passes through the chopping board 54, the second clamping plate 52, and the first clamping plate 51, that is, through holes for the rotating shaft of the centrifugal paddle to pass through are opened at the central positions of the two clamping plates and the chopping board 54. The through hole sizes of the chopping board 54 and the second clamping plate 52 are larger than the radial dimension of the rotating shaft of the centrifugal paddle to leave space for the lateral movement of the chopping board 54 and the second clamping plate 52.

[0056] The above are all the preferred embodiments of this application. The protection scope of this application is not limited accordingly. Therefore, all equivalent changes made according to the structure, shape, and principle of this application should be covered within the protection scope of this application.

Claims

1. A long-term collection device for animal bile, characterized in that: The invention comprises a medication chamber (1) and a connecting tube (2), wherein the medication chamber (1) comprises a chamber body (11) and a needle insertion rubber plate (13), wherein the chamber body (11) is provided with a needle insertion port (12), wherein the needle insertion rubber plate (13) is fixedly connected to the chamber body (11) and closes the needle insertion port (12), wherein the chamber body (11) is provided with two pipe joints (14), wherein the connecting tubes (2) have two ends, wherein one end of a single connecting tube (2) is connected to a corresponding pipe joint (14), wherein one end of the connecting tube (2) away from the chamber body (11) is connected to the common bile duct, and the other end of the connecting tube (2) away from the chamber body (11) is connected to the duodenum; It also comprises a collecting tube (31), one end of which is connected to a collecting needle (32), and the other end of which is provided with a negative pressure drainage ball (33), and the collecting needle (32) is used to pass through the needle-threading rubber plate (13); A filter assembly (4) is provided in the chamber body (11), and the filter assembly (4) comprises a filter chamber (42) and a flow control rotor (41); the filter chamber (42) is fixedly connected to the inner side wall of the chamber body (11); along the circumference of the medication chamber (1), one end of the filter chamber (42) is open, and a filter plate (421) is fixedly provided at the other end; the flow control rotor (41) is located in the chamber body (11) and rotates; when the flow control rotor (41) rotates, the liquid in the filter chamber (42) flows from the open end to one end of the filter plate (421); The housing (11) is provided with a fixed needle assembly (5), and the fixed needle assembly (5) comprises a first clamping plate (51), a second clamping plate (52) and an operator (53); the first clamping plate (51) is fixedly connected to the housing (11); the plate surface of the first clamping plate (51) is perpendicular to the axis of the housing (11); a plurality of first through holes (511) are provided on the first clamping plate (51); a guide slope (512) is provided on one side of the first clamping plate (51) facing the needle threading port (12) and between adjacent first through holes (511); The holding plate (52) is located on the side of the first clamping plate (51) away from the needle-threading rubber plate (13), the second clamping plate (52) is slidably connected to the warehouse body (11), a plurality of second through holes (521) are opened on the second clamping plate (52), and the number of the second through holes (521) and the first through holes (511) are the same, the collecting needle (32) passes through the first through hole (511) and the second through hole (521) in sequence, and the operator (53) is used to control the movement of the second clamping plate (52), and the moving direction of the second clamping plate (52) is parallel to the plate surface.

2. The long-term animal bile collection device according to claim 1, characterized in that: The connecting tube (2) is provided with a one-way valve (21), and the one-way valve (21) allows the liquid in the connecting tube (2) to flow from the common bile duct through the medication chamber (1) to the duodenum.

3. The long-term animal bile collection device according to claim 1, characterized in that: The control rotor (41) is a centrifugal paddle, and the centrifugal paddle is coaxially rotatably connected to the bin body (11). The filtering assembly (4) includes a one-way bearing (46), a control gear (43), a control rack (44), and a reciprocating spring (45). The control gear (43) is coaxially rotatably connected to the bin body (11). The control gear (43) and the rotating shaft of the centrifugal paddle are coaxially connected through the one-way bearing (46). The control rack (44) meshes with the control gear (43). The control rack (44) is slidably connected to the bin body (11). One end of the reciprocating spring (45) is connected to the bin body (11), and the other end is connected to the control rack (44). One end of the control rack (44) is located outside the bin body (11).

4. The long-term animal bile collection device according to claim 3, characterized in that: A check valve plate (422) is provided at the open end of the filtering bin (42). The check valve plate (422) is hinged to the filtering bin (42), and a torsion spring is provided on the hinge shaft. In the natural state, the check valve plate (422) seals the open end of the filtering bin (42). When the centrifugal paddle rotates, the check valve plate (422) flips into the filtering bin (42).

5. The long-term animal bile collection device according to claim 1, characterized in that: The operator (53) is a rebounder. The rebounder is fixedly connected to the bin body (11). The button of the rebounder is located outside the bin body (11). The moving direction of the push block of the rebounder is the same as the moving direction of the second clamping plate (52). A surplus spring (531) is connected between the push block of the rebounder and the second clamping plate (52). In the natural state, the rebounder keeps the second clamping plate (52) stationary at two positions. At one position, the second through hole (521) corresponds to and communicates with the first through hole (511). At the other position, the second clamping plate (52) seals the first through hole (511).

6. The long-term animal bile collection device according to claim 5, characterized in that: The needle fixing assembly (5) further includes an anvil (54). The anvil (54) is located on the side of the second clamping plate (52) away from the first clamping plate (51). An installation ring groove (112) is provided on the inner wall of the bin body (11). The edge of the anvil (54) is located in the installation ring groove (112). A hollow rubber strip (55) is fixedly connected to the bottom of the installation ring groove (112). The hollow rubber strip (55) abuts against the edge of the anvil (54).

7. The long-term collection device for animal bile according to claim 6, wherein: The collection needle head (32) includes a solid part (322) and a hollow part (321) that are integrally formed coaxially. The solid part (322) is located at one end of the hollow part (321). The end of the hollow part (321) away from the solid part (322) communicates with the collection tube (31). A liquid passing hole (323) is formed in the side wall of the hollow part (321). The liquid passing hole (323) is located on the side of the first clamping plate (51) away from the second clamping plate (52). A retaining edge (324) is fixedly connected to the side wall of the solid part (322). The length direction of the retaining edge (324) is the circumferential direction of the collection needle head (32). The retaining edge (324) is located on the side of the first clamping plate (51) or the second clamping plate (52) away from the needle-piercing rubber plate (13).

Images