Combined parameter measurement device

Abstract

The present application discloses a combined parameter measurement device, in which the first end of a sample suction and discharge unit is used as a liquid suction port or a liquid discharge port, the second end of the sample suction and discharge unit is connected to the first end of a first three-way unit through a first pipeline unit, the second end of the first three-way unit is connected to the first end of a first on-off control unit through a second pipeline unit, the second end of the first on-off control unit is connected to the first end of a sample discharge unit through a third pipeline unit, the third end of the first three-way unit is connected to the first end of a second on-off control unit through a fourth pipeline unit, the second end of the second on-off control unit is connected to the first end of a second three-way unit through a fifth pipeline unit, the second end of the sample discharge unit is connected to the second end of the second three-way unit through a sixth pipeline unit, and the sample suction unit is connected to the third end of the second three-way unit through a seventh pipeline unit. Based on the above method, the use flexibility of the combined parameter measurement device can be improved.

Description

Technical Field

[0001] The present application relates to the technical field of in vitro diagnosis, and in particular to a combined parameter measurement device. Background Art

[0002] In vitro diagnostics are widely used in clinical biochemistry, immunology, microbiology, molecular diagnosis and other fields, especially in timely and accurate identification of pathogens, monitoring of chronic diseases, and early screening. With its rapid development, the number of items that can be detected by a single machine is increasing, and the speed of the whole machine is getting faster and faster, which puts higher requirements on the flexibility of the whole equipment. Summary of the invention

[0003] The main technical problem solved by the present application is how to improve the use flexibility of the combined parameter measurement device.

[0004] In order to solve the above technical problems, the technical solution adopted in the present application is: a combined parameter measurement device, including a sample suction and discharge unit, a sample discharge unit, a sample suction unit, a first three-way unit, a second three-way unit, a first on-off control unit, a second on-off control unit, a first pipeline unit, a second pipeline unit, a third pipeline unit, a fourth pipeline unit, a fifth pipeline unit, a sixth pipeline unit and a seventh pipeline unit; the first end of the sample suction and discharge unit is used as a liquid suction port or a liquid discharge port, and the second end of the sample suction and discharge unit is connected to the first end of the first three-way unit through the first pipeline unit; the second end of the first three-way unit is connected to the first end of the first on-off control unit through the second pipeline unit, and the second end of the first on-off control unit is connected to the first end of the sample discharge unit through the third pipeline unit; the third end of the first three-way unit is connected to the first end of the second on-off control unit through the fourth pipeline unit, the second end of the second on-off control unit is connected to the first end of the second three-way unit through the fifth pipeline unit, the second end of the sample discharge unit is connected to the second end of the second three-way unit through the sixth pipeline unit, and the sample suction unit is connected to the third end of the second three-way unit through the seventh pipeline unit.

[0005] Among them, the sample aspiration and discharge unit is used to aspirate liquid through the aspiration port, or to discharge liquid through the discharge port; the content of the sample aspiration unit is greater than the content of the sample discharge unit; when the sample is not aspirated into the sample aspiration and discharge unit, the sample aspiration and discharge unit is aspirated only by the sample aspiration unit, and / or, when the sample aspiration and discharge unit has aspirated the sample, the sample aspiration and discharge unit is discharged only by the sample discharge unit.

[0006] Among them, the content volume of the fourth pipeline unit, or the content volume of the fifth pipeline unit, or the sum of the content volumes of the fourth pipeline unit and the fifth pipeline unit is greater than a preset content volume value; the preset content volume value is greater than or equal to 3 times the content volume of the sample discharge unit, and / or the preset content volume value is less than or equal to 2 times the content volume of the sample suction unit, and / or the content volume of the sample suction unit is greater than or equal to 30 times the content volume of the sample discharge unit; and / or, when the first on-off control unit and the second on-off control unit are both controlled to be turned on, the driving power of the sample suction unit is the first power, and when the first on-off control unit is controlled to be turned on and the second on-off control unit is turned off, the driving power of the sample suction unit is the second power, and the first power is less than the second power.

[0007] In which, an optical measuring device is arranged outside at least part of the outer wall of the first pipeline unit; in the first pipeline unit, the sub-pipeline located between the measuring point of the optical measuring device and the first end of the first three-way unit is the first sub-pipeline unit, and the tube length of the first sub-pipeline unit is greater than or equal to 500 mm, and / or, the inner tube diameter of the first sub-pipeline unit is less than or equal to 2 mm, and / or, in the first pipeline unit, the sub-pipeline located between the measuring point of the optical measuring device and the second end of the sample suction and discharge unit is the second sub-pipeline unit, and the tube length of the second sub-pipeline unit is greater than or equal to 80 mm.

[0008] Among them, the first pipeline unit includes a first non-measuring pipeline, a measuring pipeline and a second non-measuring pipeline connected in sequence, and an optical measuring device is arranged on the outer wall of the measuring pipeline; the pipe material of the measuring pipeline is different from the pipe material of the first non-measuring pipeline and the pipe material of the second non-measuring pipeline, and / or the transmittance of the measuring pipeline is greater than or equal to 90%, and the haze is less than or equal to 5%.

[0009] The sample suction and discharge unit comprises a first opening and a second opening, the first opening is located at the upper end of the sample suction and discharge unit, and the second opening is located at the lower end of the sample suction and discharge unit; the radial cross-sectional area of ​​the first opening is larger than the radial cross-sectional area of ​​the second opening, the first opening is connected to the first pipeline unit, and the second opening is used as a liquid suction port or a liquid discharge port; and / or, the second opening is arranged on the side wall of the sample suction and discharge unit; and / or, the content of the sample suction and discharge unit is less than or equal to half of the content of the sample discharge unit; and / or, the surface roughness of the inner wall of the sample suction and discharge unit located within the second opening is greater than or equal to 0. 2 microns; and / or, the surface roughness of the outer wall of the sample aspiration and discharge unit outside the second opening is greater than or equal to 0.3 microns; and / or, a plurality of grooves are provided on the outer wall of the sample aspiration and discharge unit, and the grooves are extended along the axial direction of the sample aspiration and discharge unit; and / or, the minimum distance between the sample aspiration and discharge unit and the part of the pipeline fixed at both ends of the first pipeline unit is less than 50 mm; and / or, in the first pipeline unit, the pipeline between the part of the pipeline fixed at both ends of the first pipeline unit and the sample aspiration and discharge unit is a interference reduction pipeline, and at least part of the pipeline in the interference reduction pipeline is a curved pipeline.

[0010] Wherein, the sample suction unit and the sample discharge unit are both plunger pumps; and / or, the opening direction of the sample suction unit connected to the seventh pipeline unit and the opening direction of the first end of the sample discharge unit are both set upward.

[0011] The opening axis of the first end of the first three-way unit and the opening axis of the second end of the first three-way unit are both located on the target straight line; and / or the opening direction of the third end of the first three-way unit is perpendicular to the target straight line.

[0012] Among them, an optical measuring device is arranged outside at least part of the outer wall of the first pipeline unit, and the optical measuring device is used to heat and / or detect the sample at the measurement location. The heating power of the optical measuring device during heating is 3W-15W, and / or the length of the heated pipeline is greater than or equal to 40 mm and less than or equal to 60 mm.

[0013] The combined parameter measurement device further comprises a swab and a swab two-way valve, the swab is arranged on the sample suction and discharge unit, the sample suction unit is also used for performing cleaning operation through the swab, the swab has a first opening and a second opening, the second opening is used for connecting to the waste liquid pool, wherein the first end or the second end of the sample suction unit is connected to the first opening of the swab through the swab two-way valve;

[0014] And / or, the combined parameter measurement device also includes a flow chamber, a flow chamber three-way connector and a flow chamber two-way valve; the sample discharge unit is also used to perform sample auxiliary operation on the flow chamber; the first end of the flow chamber three-way connector is connected to the sample discharge unit through the flow chamber two-way valve; the second end of the flow chamber three-way connector is connected to the sample port of the flow chamber; and the third end of the flow chamber three-way connector is connected to the sample source.

[0015] The beneficial effects of the present application are as follows: different from the prior art, in the technical solution of the present application, the first end of the sample aspiration and discharge unit is used as a liquid aspiration port or a liquid discharge port, the second end of the sample aspiration and discharge unit is connected to the first end of the first three-way unit through the first pipeline unit, the second end of the first three-way unit is connected to the first end of the first on-off control unit through the second pipeline unit, the second end of the first on-off control unit is connected to the first end of the sample discharge unit through the third pipeline unit, the third end of the first three-way unit is connected to the first end of the second on-off control unit through the fourth pipeline unit, the second end of the second on-off control unit is connected to the first end of the second three-way unit through the fifth pipeline unit, the second end of the sample discharge unit is connected to the second end of the second three-way unit through the sixth pipeline unit, the sample suction unit is connected to the third end of the second three-way unit through the seventh pipeline unit, and in the above Based on the structure, the first on-off control unit can be controlled to be closed and the second on-off control unit to be opened, and the sample suction unit can be controlled to suck the sample through the sample suction and discharge unit. The first on-off control unit can be controlled to be opened and the second on-off control unit can be controlled to be closed, and the sample suction unit can be controlled to transport the sample to the sample discharge unit, and then the sample discharge unit can be controlled to spit out the sample. The first on-off control unit can be controlled to be opened and the second on-off control unit can be controlled to be opened, and then the sample suction unit and the sample discharge unit can be controlled to spit out the sample through the sample suction and discharge unit together, thereby realizing different control methods of the first on-off control unit and the second on-off control unit, and using different unit combinations to inhale and spit out the sample in different situations, so as to meet the requirements of the suction and spitting capacity of the sample in the corresponding situation, thereby improving the flexibility of use of the combined parameter measurement device. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0017] Figure 1 It is a structural schematic diagram of an embodiment of the combined parameter measurement device of the present application;

[0018] Figure 2 is a structural schematic diagram of another embodiment of the combined parameter measurement device of the present application;

[0019] Figure 3 It is a schematic cross-sectional structure diagram of an embodiment of the sample suction and discharge unit of the present application;

[0020] Figure 4 It is a side view structural schematic diagram of an embodiment of the sample suction and discharge unit of the present application;

[0021] Figure 5 It is a structural schematic diagram of another embodiment of the combined parameter measurement device of the present application.

[0022] Among them, 101, sample suction and discharge unit; 102, sample discharge unit; 103, sample suction unit; 104, first three-way unit; 105, second three-way unit; 106, first on-off control unit; 107, second on-off control unit; 108, first pipeline unit; 109, second pipeline unit; 110, third pipeline unit; 111, fourth pipeline unit; 112, fifth pipeline unit; 113, sixth pipeline unit; 114, seventh pipeline unit; 115, optical measuring device; 116, swab; 117, flow chamber; 118, flow chamber three-way connector. DETAILED DESCRIPTION

[0023] The present application is further described in detail below in conjunction with the accompanying drawings and examples. It is particularly noted that the following examples are only used to illustrate the present application, but are not intended to limit the scope of the present application. Similarly, the following examples are only some embodiments of the present application rather than all embodiments, and all other embodiments obtained by those of ordinary skill in the art without making creative work are within the scope of protection of the present application.

[0024] Reference to "embodiments" herein means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0025] In the description of this application, it should be noted that, unless otherwise clearly specified and limited, the terms "install", "set", "connect", and "connect" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or connected through an intermediate medium. For ordinary technicians in this field, the above-mentioned specific meanings belonging to this application can be connected according to specific circumstances.

[0026] In vitro diagnostics are widely used in clinical biochemistry, immunology, microbiology, molecular diagnosis and other fields, especially in timely and accurate identification of pathogens, monitoring of chronic diseases, and early screening. With its rapid development, higher requirements are placed on the whole equipment, such as the number of items that can be detected by a single machine is increasing, and the speed of the whole machine is getting faster and faster.

[0027] Different testing items have different applicable scenarios and requirements, including: sample volume required for testing, testing speed, reagent dosage, etc. For example, the actual amount of blood used in some testing items is very small, only about 2 microliters is enough to complete the test, while some testing items use more than several hundred microliters of blood in a single project; some projects have a very fast testing speed, while some projects require samples and reagents to fully react and the incubation time is very long, which results in a longer total testing time.

[0028] This application proposes a joint parameter measurement device to be applicable to more scenarios and requirements at the same time, see Figure 1 , Figure 1 It is a structural schematic diagram of an embodiment of the combined parameter measurement device of the present application, which includes a sample suction and discharge unit 101, a sample discharge unit 102, a sample suction unit 103, a first three-way unit 104, a second three-way unit 105, a first on-off control unit 106, a second on-off control unit 107, a first pipeline unit 108, a second pipeline unit 109, a third pipeline unit 110, a fourth pipeline unit 111, a fifth pipeline unit 112, a sixth pipeline unit 113 and a seventh pipeline unit 114.

[0029] The first end of the sample aspiration and discharge unit 101 is used as a liquid aspiration port or a liquid discharge port, and the second end of the sample aspiration and discharge unit 101 is connected to the first end of the first three-way unit 104 through the first pipeline unit 108 .

[0030] The sample aspiration and discharge unit 101 may specifically refer to a pipette needle or a sampling needle or other types of devices that can be used to aspirate and discharge samples, which is not limited here.

[0031] The first three-way unit 104 and the second three-way unit 105 may specifically be three-way connectors, three-way valves, or other types of connecting devices with at least three connectors, which are not limited here.

[0032] The second end of the first three-way unit 104 is connected to the first end of the first on-off control unit 106 through the second pipeline unit 109 , and the second end of the first on-off control unit 106 is connected to the first end of the sample discharge unit 102 through the third pipeline unit 110 .

[0033] The first on-off control unit 106 and the second on-off control unit 107 may be two-way valves, three-way valves, or other types of devices capable of switching their own conduction states, which are not limited here.

[0034] When the first on-off control unit 106 is turned on, the sample discharge unit 102 can be connected to the sample suction and discharge unit 101 through the third pipeline unit 110, the first on-off control unit 106, the second pipeline unit 109 and the first pipeline unit 108 to discharge the sample. When the first on-off control unit 106 is turned off, the connection between the sample discharge unit 102 and the sample suction and discharge unit 101 can be disconnected.

[0035] The third end of the first three-way unit 104 is connected to the first end of the second on-off control unit 107 through the fourth pipeline unit 111, the second end of the second on-off control unit 107 is connected to the first end of the second three-way unit 105 through the fifth pipeline unit 112, the second end of the sample discharge unit 102 is connected to the second end of the second three-way unit 105 through the sixth pipeline unit 113, and the sample suction unit 103 is connected to the third end of the second three-way unit 105 through the seventh pipeline unit 114.

[0036] When the second on-off control unit 107 is on, the sample suction unit 103 can be connected to the sample suction and discharge unit 101 through the seventh pipeline unit 114, the second three-way unit 105, the fifth pipeline unit 112, the fourth pipeline unit 111 and the first pipeline unit 108 to suck the sample. When the second on-off control unit 107 is off, the direct connection between the sample suction unit 103 and the sample suction and discharge unit 101 can be disconnected, but when the first on-off control unit 106 is on, the sample suction unit 103 can still be indirectly connected to the sample suction and discharge unit 101 through the sample discharge unit 102.

[0037] Specifically, in one example, both the sample discharge unit 102 and the sample suction unit 103 can be units with suction and exhalation capabilities, wherein the content of the sample discharge unit 102 can be smaller than the content of the sample suction unit 103, but the accuracy of the sample discharge unit 102 can be greater than the accuracy of the sample suction unit 103. In this way, the sample suction unit 103 can have a higher liquid suction speed, which is conducive to improving the sampling efficiency, while the sample discharge unit 102 has a higher liquid discharge accuracy, which is conducive to improving the accuracy of sample separation.

[0038] Based on the above structure, there are several control methods:

[0039] First, control the first on-off control unit 106 to be closed and the second on-off control unit 107 to be opened. At this time, the sample suction unit 103 can be controlled to inhale the sample. Since the sample suction unit 103 can be set to a suction and exhalation unit that is more suitable for sample collection, such as a suction and exhalation unit with a relatively large internal volume, the efficiency of inhaling the sample to complete the sample collection operation can be higher.

[0040] Second, the first on-off control unit 106 is controlled to be turned on and the second on-off control unit 107 is controlled to be turned off. At this time, the sample discharge unit 102 can be controlled to discharge the collected sample. Since the sample discharge unit 102 can be set to a suction and exhalation unit that is more suitable for sample discharge, such as a suction and exhalation unit with a relatively small internal volume, the sample discharge can complete the sample sorting operation with higher accuracy.

[0041] Third, control the first on-off control unit 106 to open, and the second on-off control unit 107 to open. At this time, the sample suction unit 103 is connected to both the second end of the sample discharge unit 102 and the first end of the sample discharge unit 102. This control method can usually be used in scenarios where the speed of suctioning or discharging samples needs to be increased without paying attention to accuracy, to perform sample suction or discharge, thereby further improving the efficiency of collection or sample separation operations.

[0042] Fourth, when there is no need to inhale or discharge the sample, the first on-off control unit 106 can be controlled to be closed, and the second on-off control unit 107 can be closed, thereby reducing the possibility of external pollutants contaminating the sample discharge unit 102 and the sample intake unit 103, and improving the reliability of the combined parameter measurement device.

[0043] In summary, in situations with different needs, the combined parameter measurement device can have the above-mentioned structural basis, and by reasonably controlling the opening and closing of the first on-off control unit 106 and the second on-off control unit 107, different unit combinations can be used to inhale and exhale samples in different situations to adapt to the needs of sample aspiration and exhalation capacity in corresponding situations, thereby improving the flexibility of use of the combined parameter measurement device.

[0044] Different from the prior art, in the technical solution of the present application, the first end of the sample suction and discharge unit is used as a liquid suction port or a liquid discharge port, the second end of the sample suction and discharge unit is connected to the first end of the first three-way unit through the first pipeline unit, the second end of the first three-way unit is connected to the first end of the first on-off control unit through the second pipeline unit, the second end of the first on-off control unit is connected to the first end of the sample discharge unit through the third pipeline unit, the third end of the first three-way unit is connected to the first end of the second on-off control unit through the fourth pipeline unit, the second end of the second on-off control unit is connected to the first end of the second three-way unit through the fifth pipeline unit, the second end of the sample discharge unit is connected to the second end of the second three-way unit through the sixth pipeline unit, and the sample suction unit is connected to the third end of the second three-way unit through the seventh pipeline unit. Based on the above structure, The first on-off control unit can be controlled to be closed and the second on-off control unit to be opened, and the sample suction unit can be controlled to suck in the sample through the sample suction and discharge unit. The first on-off control unit can be controlled to be opened and the second on-off control unit can be controlled to be closed, and the sample suction unit can be controlled to transport the sample to the sample discharge unit, and then the sample discharge unit can be controlled to discharge the sample. The first on-off control unit can be controlled to be opened and the second on-off control unit can be controlled to be opened, and then the sample suction unit and the sample discharge unit can be controlled to discharge the sample through the sample suction and discharge unit together, thereby realizing different control methods of the first on-off control unit and the second on-off control unit, and using different unit combinations to suck and discharge the sample in different situations to meet the requirements for the suction and discharge capacity of the sample in corresponding situations, thereby improving the flexibility of use of the combined parameter measurement device.

[0045] In one embodiment, the sample suction and discharge unit 101 is used to suck liquid through the suction port, or to discharge liquid through the discharge port. The content of the sample suction unit 103 is greater than the content of the sample discharge unit 102 .

[0046] When the sample aspirating and discharging unit 101 does not aspirate the sample, the sample aspirating and discharging unit 101 is driven to aspirate the sample only by the sample aspirating unit 103 .

[0047] And / or, when the sample aspiration and discharge unit 101 has aspirated the sample, the sample aspiration and discharge unit 101 is driven to discharge the sample only by the sample discharge unit 102 .

[0048] Specifically, when the sample suction and discharge unit 101 does not absorb the sample, the first on-off control unit 106 can be controlled to be closed and the second on-off control unit 107 can be turned on as described in the control method mentioned above. At this time, the sample suction unit 103 can be controlled to drive the sample suction and discharge unit 101 to absorb the sample. Since the content of the sample suction unit 103 is relatively large, the efficiency of the sample suction and discharge operation can be higher. At this time, the sample discharge unit 102 can also be controlled to drive the sample suction and discharge unit 101 to absorb the sample together with the sample suction unit 103, which can make the efficiency of the sample suction and discharge operation higher. However, in order to ensure its efficiency, the sample suction unit 103 must be started due to its large capacity. Although the addition of the sample discharge unit 102 improves the efficiency, the suction efficiency of the sample discharge unit 102 itself is not as good as the suction efficiency of the sample suction unit 103 itself.

[0049] When the sample suction and discharge unit 101 has sucked in the sample, the first on-off control unit 106 can be controlled to open and the second on-off control unit 107 can be controlled to close as described in the control method mentioned above. At this time, only the sample discharge unit 102 can be controlled to drive the sample suction and discharge unit 101 to discharge the collected sample. Since the content of the sample discharge unit 102 is relatively small, the accuracy of the sample discharge to complete the sample separation operation can be higher. At this time, the sample discharge unit 102 and the sample suction unit 103 cannot be controlled to drive the sample suction and discharge unit 101 to discharge the sample at the same time, and the sample suction unit 103 cannot be controlled to drive the sample suction and discharge unit 101 to discharge the sample. In this case, since the sample suction unit 103 has a larger capacity, its accuracy is not as good as the sample discharge unit 102, which will affect the accuracy of the sample discharge to complete the sample separation operation.

[0050] Based on the above method, by setting a sample suction unit 103 with a relatively large content and a sample discharge unit 102 with a relatively small content, and cooperating with the corresponding control methods of the first on-off control unit 106 and the second on-off control unit 107, it is possible to improve the efficiency of sucking in samples for collection operations and the accuracy of discharging samples for sample separation operations.

[0051] In one embodiment, the content of the fourth pipeline unit 111, or the content of the fifth pipeline unit 112, or the sum of the content of the fourth pipeline unit 111 and the fifth pipeline unit 112 is greater than a preset content value.

[0052] The preset content volume value is greater than or equal to 3 times the content volume of the sample discharge unit 102 , and / or the preset content volume value is less than or equal to 2 times the content volume of the sample intake unit 103 .

[0053] Specifically, by making the content volume of the fourth pipeline unit 111, or the content volume of the fifth pipeline unit 112, or the sum of the content volumes of the fourth pipeline unit 111 and the fifth pipeline unit 112 greater than a preset content volume value, and making the preset content volume values ​​respectively greater than or equal to three times the content volume of the sample discharge unit 102, the pipeline section formed by the fourth pipeline unit 111 and / or the fifth pipeline unit 112 can have a larger content volume, and this section of the pipeline section with a larger content volume can be used to store cleaning liquid.

[0054] By making the preset content value less than or equal to twice the content of the sample suction unit 103, when the liquid temporarily stored in the pipeline part formed by the fourth pipeline unit 111 and / or the fifth pipeline unit 112 has a large capacity (for example, when it is used to store probe liquid or other strong cleaning liquid for cleaning the entire liquid system (including all reaction pools and all related pipelines)), by using the larger capacity sample suction unit 103 to perform two suction actions or other smaller number of suction actions, the suction of all required liquids can be completed quickly, which greatly improves the efficiency of the whole machine.

[0055] For example, after completing sample collection and sample separation, the first on-off control unit 106 can be controlled to be closed and the second on-off control unit 107 to be opened, and then the sample suction unit 103 can be controlled to suck in cleaning liquid, such as probe liquid or diluent or other types of cleaning liquid, through the sample suction and discharge unit 101, and the cleaning liquid is stored in the fourth pipeline unit 111 and / or the fifth pipeline unit 112, so as to prepare for subsequent direct control of the sample suction unit 103 to discharge the cleaning liquid through the sample suction and discharge unit 101 to achieve cleaning of a part of the pipeline, and / or control the sample suction unit 103 to suck in the cleaning liquid and transport it to the sample discharge unit 102, so as to control the sample discharge unit 102 to discharge the cleaning liquid through the sample suction and discharge unit 101 to achieve cleaning of another part of the pipeline.

[0056] Based on the above method, the fourth pipeline unit 111 and / or the fifth pipeline unit 112 can have the ability to temporarily store cleaning liquid, so that a sufficient amount of cleaning liquid can be temporarily stored there later, and then the entire combined parameter measurement device can be cleaned through reasonable control of the on-off control unit and the suction and exhalation unit, thereby reducing the possibility of multiple cycles of inhaling and discharging the cleaning liquid, improving the cleaning efficiency, and thus improving the reliability of the combined parameter measurement device.

[0057] Furthermore, the liquid stored in the fourth pipeline unit 111 and / or the fifth pipeline unit 112 is the probe liquid. The probe liquid generally has strong oxidizing properties and can be hydrolyzed to generate secondary organisms with strong oxidizing properties, which can oxidize reducing substances, which can not only cause the microorganisms to eventually lose their functions and be unable to reproduce or infect, but also may have a certain degree of corrosiveness to the pipelines made of polymer materials due to the long storage time. By using the larger capacity sample suction unit 103, the efficiency of suction and / or discharge of the probe liquid can be accelerated, thereby reducing the temporary storage time of the probe liquid in the pipeline, and further reducing the corrosive damage to the pipeline caused by the probe liquid.

[0058] In one embodiment, the volume of the sample suction unit 103 is greater than or equal to 30 times the volume of the sample discharge unit 102 .

[0059] Specifically, by making the content of the sample suction unit 103 greater than or equal to 30 times the content of the sample discharge unit 102, the sample discharge unit 102 can have a sufficiently small-scale characteristic relative to the sample suction unit 103. Within the common scale range of the sample suction unit 103 or the sample discharge unit 102 of the IVD (In Vitro Diagnosis) device, its repeatability (including suction and discharge) accuracy is less than a fixed percentage. For example, when the content of the sample suction unit 103 is equal to 30 times the content of the sample discharge unit 102, the repeatability of the sample discharge unit 102 is about 1 / 30 of the repeatability of the sample suction unit 103, so that the accuracy of the sample discharge unit 102 is nearly 2 orders of magnitude higher than that of the sample suction unit 103, thereby greatly improving the accuracy of the liquid discharge of the entire device. Based on this, when the sample is discharged through the sample discharge unit 102, due to the small-scale characteristics, the sample discharge unit 102 can have a sufficiently high control accuracy for the sample or other liquid discharged in each step or each unit time, which can improve the accuracy of the sample discharge unit 102 in controlling the amount of liquid it transports, thereby improving the accuracy of the sample separation operation based on the sample discharge unit 102, thereby improving the accuracy of the sample test results of the sample liquid prepared by the sample obtained based on the subsequent sample separation operation, and improving the reliability of the joint parameter measurement device. More importantly, in the case where the blood volume of some test items in the whole device differs by 2-3 orders of magnitude, the above scheme can be better applied to various scenarios, ensuring both the detection accuracy of small blood volume items and the detection efficiency of large blood volume items.

[0060] In one embodiment, if Figure 1 As shown, an optical measuring device 115 is disposed outside at least part of the outer wall of the first pipeline unit 108 .

[0061] In the first pipeline unit 108 , the sub-pipeline located between the measuring position of the optical measuring device 115 and the first end of the first three-way unit 104 is a first sub-pipeline unit.

[0062] The length of the first sub-pipeline unit is greater than or equal to 500 mm, and / or the inner diameter of the first sub-pipeline unit is less than or equal to 2 mm.

[0063] Specifically, the measurement point of the optical measuring device 115 can be a point in the first sub-pipeline unit, or a part of the pipeline in the first sub-pipeline unit, which can be determined according to actual needs and is not limited here.

[0064] By making the first sub-pipeline unit located between the measuring point of the optical measuring device 115 and the first end of the first three-way unit 104 have a tube length greater than or equal to 500 mm and / or an inner tube diameter less than or equal to 2 mm, the first sub-pipeline unit can be made to vibrate less when the sample flows through the first sub-pipeline unit due to the movement of liquid inside the first sub-pipeline unit, thereby reducing the degree of disturbance to the sample in the first sub-pipeline unit.

[0065] It should be noted here that the technical solution of the present application is a system solution with fluid as the main medium. The impact of fluid oscillation shock caused by the action of the control element or the drive element on the stability of the detection element is always a problem worthy of in-depth study. The rapid switching of the control element or the rapid start and stop of the drive element will inevitably form a series of liquid shocks in the pipeline assembly, which will propagate and reflect in the pipeline system, and may produce continuous flow oscillations. Improper design may even cause failure of the seal of the liquid system, liquid leakage, and even damage to the pump and valve structure, impaired function, and system instability. Therefore, it is of great significance to study the dynamic characteristics such as the spatial distribution of liquid shock and the law of pressure transients in the liquid circuit and their influencing factors, and establish the system equations of fluid and pipeline components, to improve the design of system pipeline components, suppress and eliminate the harm of liquid shock to the pipeline component system, and especially to improve the reliability of the measurement system.

[0066] The article "A second draft of a non-technical article on universality" mentions that the universal laws of fluid mechanics also fail at the mesoscopic scale: this scale is larger than the microscopic scale of a single molecule, but smaller than the macroscopic scale, where the universal laws apply. A typical example of a mesoscopic fluid is blood flowing through blood vessels; the blood cells that make up this fluid are so large that they cannot be simply regarded as a collection of microscopic molecules, but should be considered as mesoscopic entities with complex behaviors. Establishing accurate mathematical models for such materials remains an ongoing challenge. Because of this, this poses a great challenge to accurate measurements in IVD (In Vitro Diagnostic) devices.

[0067] In order to obtain the reasonable parameters mentioned in our above technical solution, we borrowed the fluid mechanics model constructed in the paper Pomerenka O, Carrillo Segura S, Cao F, Wu J, Ristroph L. Hydrodynamics of finite-length pipes at intermediate Reynolds numbers[J]. Journal of Fluid Mechanics, 2023,959: A28. to analyze the above fluid characteristics. The specific model formula is as follows:

[0068]

[0069] Due to the mesoscopic characteristics of blood samples, the Reynolds number superimposed on the critical value Many existing rules of thumb for fluid mechanics are no longer applicable. For example, the effects of local turbulent flow development caused by rapid switching of control elements or rapid start and stop of drive elements have been shown to no longer be limited to a relatively short inlet region, whose length It is relatively sensitive to Re, and the above model can accurately calculate fluid friction, pressure-flow relationship and other characteristics. Among them, the six parameters and their values ​​are = 0.85, Re∗ = 2000, δ = 200, b∞ = 1, k = 0.05 and =0.04. The pipe diameter is the upper limit of the inner diameter of the first sub-pipeline unit or the second sub-pipeline unit, which is 2 mm. At present, the detection speed of the whole in vitro diagnostic equipment is getting faster and faster. In addition, the present invention uses a large-capacity sample suction unit 103 (larger than the capacity of the sample discharge unit 102 by nearly 2 orders of magnitude) to speed up the sample suction speed, resulting in the flow velocity in the pipeline, especially the local flow velocity, which may exceed 20 m / s. Therefore, the Reynolds number of the fluid flow state in the pipeline has a greater probability of falling into the critical interval Reynolds number. , and then substitute other empirical parameters into the above formula, and multiply the calculated pipeline length of the first sub-pipeline unit by a certain redundancy coefficient (selected as 3 based on experience), then the sum of the lengths of the first sub-pipeline units is 0.4931m. After appropriate rounding, the length of the first sub-pipeline unit should be greater than or equal to 500mm.

[0070] This has been verified in our engineering practice. If the sample is greatly disturbed, it is easy for the polymerization parameters in the sample (such as the erythrocyte sedimentation rate (Erythrocyte Sedimentation Rate) in the blood sample) or other types of parameters that are easily disturbed by the disturbance to change. For example, when the optical measuring device 115 is a device for detecting the polymerization parameters of the sample, the polymerization parameters obtained by detecting the sample thereafter will easily be distorted. Therefore, based on the above method, reducing the degree of disturbance of the sample in the first sub-pipeline unit can improve the accuracy of sample detection.

[0071] Alternatively, if Figure 1 As shown, in the first pipeline unit 108, the sub-pipeline between the measuring position of the optical measuring device 115 and the second end of the sample aspiration and discharge unit 101 is the second sub-pipeline unit.

[0072] The tube length of the second sub-pipeline unit is greater than or equal to 80 mm.

[0073] Specifically, by making the second sub-pipeline unit located between the measuring point of the optical measuring device 115 and the second end of the sample aspiration and discharge unit 101 have a tube length greater than or equal to 80 mm, and limiting the tube length of the second sub-pipeline unit, it is convenient to replace the sample aspiration and discharge unit 101 multiple times. Since the sample aspiration and discharge unit 101 needs to break the test tube cap through impact, frequent high-speed impacts cause it to be easily damaged or worn and often need to be replaced. The sample aspiration and discharge unit 101 and the second sub-pipeline unit are often bonded by glue. Therefore, the pipeline end of the second sub-pipeline unit must be destroyed when replacing it (generally, a section of the interface pipeline that has been bonded at the end can be cut off).

[0074] In an actual application, when the sample aspiration and discharge unit 101 needs to be replaced, the portion of the first end of the second sub-pipeline unit connected to the sample aspiration and discharge unit 101 is cut off, and then the remaining first end of the second sub-pipeline unit is connected to the replaced sample aspiration and discharge unit 101. That is, in the process of replacing the sample aspiration and discharge unit 101 multiple times, the tube length of the second sub-pipeline unit will gradually decrease. Therefore, this embodiment proposes that the tube length of the second sub-pipeline unit is greater than 80 mm, ensuring that in the process of replacing the sample aspiration and discharge unit 101, the tube length of the second sub-pipeline unit is sufficient. The user does not need to replace the entire tube of the second sub-pipeline unit, but only needs to cut off a section of the tube, thereby simplifying the operation of replacing the sample aspiration and discharge unit 101 and improving the user experience.

[0075] Since the second sub-pipeline unit has a certain curvature and one end thereof needs to move along with the vertical movement of the sample suction and discharge unit 101, it must have a certain basic pipe length. Adding the additional pipe length, the pipe length of the second sub-pipeline unit should be greater than 80 mm. The additional pipe length can be obtained by multiplying the number of possible replacements of the sample suction and discharge unit 101 within the maintenance period by the pipe length of the end cut off each time, plus a certain margin.

[0076] In addition, having a sufficient tube length can also make it possible for the second sub-pipeline unit to have a smaller amplitude of shaking due to the movement of liquid in the second sub-pipeline unit when the sample flows through it, thereby making the disturbance degree of the sample in the second sub-pipeline unit smaller. Based on the above method, the disturbance degree of the sample in the pipeline located at the measurement point of the optical measuring device 115 and its vicinity can be smaller, thereby making the accuracy of sample detection based on the optical measuring device 115 higher.

[0077] In one embodiment, if Figure 1 As shown, the first pipeline unit 108 includes a first non-measurement pipeline, a measurement pipeline, and a second non-measurement pipeline connected in sequence, and an optical measurement device 115 is provided on the outer wall of the measurement pipeline.

[0078] The pipe material of the measuring pipeline is different from the pipe material of the first non-measuring pipeline and the pipe material of the second non-measuring pipeline, and / or the light transmittance of the measuring pipeline is greater than or equal to 90%, and the haze is less than or equal to 5%.

[0079] Specifically, Figure 1 As shown, one end of the first non-measuring pipeline is connected to the sample suction and discharge unit 101, the other end of the first non-measuring pipeline is connected to one end of the measuring pipeline, an optical measuring device 115 is provided on the outer wall of the measuring pipeline, the other end of the measuring pipeline is connected to one end of the second non-measuring pipeline, and the other end of the second non-measuring pipeline is connected to the first end of the first three-way unit 104.

[0080] It should be noted that in order to ensure that the sample in the measuring pipeline is sufficiently stable during detection by the optical measuring device 115, the two ends of the measuring pipeline can be relatively fixed so that the relative position between the two ends of the measuring pipeline remains unchanged. Furthermore, the measuring pipeline after the two ends are fixed can be made into a straight pipeline or a pipeline with a curvature less than a preset curvature, thereby reducing the possibility of the sample in the pipeline being disturbed too much due to the change of direction of the pipeline.

[0081] The material of the measuring pipeline is different from the material of the first non-measuring pipeline and the material of the second non-measuring pipeline, and / or the transmittance of the measuring pipeline is greater than or equal to 90%, and the haze is less than or equal to 5%. For example, the measuring pipeline can be a square glass tube, a round glass tube, or other types of pipes that meet the above transmittance and haze requirements for the optical measuring device 115 to detect. It is not limited here, and the accuracy and stability of the optical measuring device 115 in sample detection are improved. Here, haze is the percentage of the transmitted light intensity that deviates from the incident light by more than 2.5° to the total transmitted light intensity. The greater the haze, the lower the gloss, transparency and imaging degree of the film, among which the magnitude of the imaging degree decrease is particularly obvious. A beam of parallel light from a standard "c" light source is irradiated vertically onto a transparent or translucent film, sheet or plate. Due to scattering inside and on the surface of the material, part of the parallel light deviates from the incident direction by more than 2.5°. The percentage of the scattered light flux Td to the light flux T2 that passes through the material is an important parameter for characterizing the optical transparency of transparent or translucent materials.

[0082] The pipe of the first non-measurement pipeline and the second non-measurement pipeline can be set to be easier to bend to improve space utilization or have other characteristics required by users, such as plastic pipes or rubber pipes or other types of pipes, depending on actual needs and not limited here.

[0083] Taking the in-tube detection of erythrocyte sedimentation rate as an example, since both the first non-measurement pipeline and the second non-measurement pipeline need to move to a large extent, the current detection method is that the first non-measurement pipeline, the measurement pipeline and the second non-measurement pipeline connected in sequence are a pipeline of the same material. Although this is easy to install and maintain, the measurement pipeline is not a glass pipeline, which can easily cause certain substances in the blood sample to penetrate into the pipeline material, making it difficult to ensure that the pipeline is clean, and it is also easy to cause pipeline aging. The accuracy of the detection performed by the optical measuring device 115 through the aged pipeline is greatly reduced, which in turn leads to an increase in the maintenance frequency. Therefore, by making the pipe material of the measurement pipeline more suitable for storing blood samples and distinguishing its material from the first non-measurement pipeline and the second non-measurement pipeline, the maintenance frequency can be reduced.

[0084] Based on the above method, the detection result obtained by the optical measuring device 115 in the combined parameter measurement device can be more accurate, and the various pipelines and pipes in the combined parameter measurement device can be reasonably arranged to improve space utilization or flexibility of use or service life, thereby improving the reliability of the combined parameter measurement device.

[0085] In one embodiment, the sample suction and discharge unit 101 has a first opening and a second opening, wherein the first opening is located at an upper end of the sample suction and discharge unit 101 , and the second opening is located at a lower end of the sample suction and discharge unit 101 .

[0086] The radial cross-sectional area of ​​the first opening is greater than that of the second opening. The first opening is connected to the first pipeline unit 108, and the second opening is used as a liquid suction port or a liquid discharge port.

[0087] And / or, the second opening is disposed on a side wall of the sample suction and discharge unit 101 .

[0088] And / or, the volume of the sample suction and discharge unit 101 is less than or equal to half of the volume of the sample discharge unit 102 .

[0089] And / or, the surface roughness of the inner wall of the sample suction and discharge unit 101 within the second opening is greater than or equal to 0.2 micrometers.

[0090] And / or, the surface roughness of the outer wall of the sample suction and discharge unit 101 outside the second opening is greater than or equal to 0.3 micrometers.

[0091] And / or, a plurality of grooves are provided on the outer wall of the sample suction and discharge unit 101 , and the grooves are extended along the axial direction of the sample suction and discharge unit 101 .

[0092] And / or, the minimum distance between the sample suction and discharge unit 101 and the part of the pipeline fixed at both ends of the first pipeline unit 108 is less than 50 mm.

[0093] And / or, in the first pipeline unit 108, the pipeline between the part of the pipeline fixed at both ends of the first pipeline unit 108 and the sample suction and discharge unit 101 is a disturbance reduction pipeline, and at least part of the pipeline in the disturbance reduction pipeline is a curved pipeline.

[0094] Specifically, the upper end of the sample aspiration and discharge unit 101 may specifically refer to an end of the sample aspiration and discharge unit 101 connected to the first pipeline unit 108 .

[0095] First, by making the radial cross-sectional area of ​​the first opening larger than the radial cross-sectional area of ​​the second opening, when the sample enters the sample suction and discharge unit 101 through the first opening and then leaves the sample suction and discharge unit 101 through the second opening, the stability and accuracy of the sample discharged through the sample suction and discharge unit 101 are high, thereby improving the accuracy of the sample separation operation in each reaction pool through the sample suction and discharge unit 101, and further improving the accuracy of sample liquid preparation and sample detection based on the sample separation operation.

[0096] Secondly, by providing the second opening on the side wall of the sample suction and discharge unit 101, when the sample suction and discharge unit 101 pierces a container storing a sample (such as a sample test tube or a reagent bottle or other types of sample containers), or enters a container storing a sample in other ways, the possibility of particles generated on the container due to the piercing or contaminants attached to the container directly entering the sample suction and discharge unit 101 through the second opening to contaminate the sample suction and discharge unit 101 and its connecting pipelines is reduced, thereby improving the accuracy of subsequent sample detection based on the sample collected by the sample suction and discharge unit 101.

[0097] Third, the content of the sample suction and discharge unit 101 is less than or equal to half of the content of the sample discharge unit 102; since the sample is driven by the sample discharge unit 102 and is eventually discharged from the second opening of the sample suction and discharge unit 101, the accuracy of the sample suction and discharge depends on the comprehensive accuracy of multiple links of the entire related pipeline system (such as from the sample discharge unit 102 to the pipeline and then to the sample suction and discharge unit 101, etc.) during the sample discharge process. However, the accuracy of the sample suction and discharge unit 101 is required first, and similar to the relationship between the capacity and accuracy of the aforementioned sample discharge unit 102 and the sample suction unit 103, the smaller the content of the sample suction and discharge unit 101, the higher its accuracy is often, thereby ensuring the sample discharge accuracy of the related pipeline system and ultimately improving the accuracy of the suction and discharge of the entire machine (especially the discharge of samples).

[0098] Fourth, see Figure 3 , Figure 3 is a schematic cross-sectional structure diagram of an embodiment of the sample suction and discharge unit of the present application, Figure 4 is a schematic diagram of a side view of an embodiment of the sample suction and discharge unit of the present application. Figure 3 and Figure 4 As shown, unlike the conventional understanding, the inner wall of the sample suction and discharge unit 101 is not as smooth as possible. The inner wall surface roughness of the sample suction and discharge unit 101 located within the second opening is greater than or equal to 0.2 microns. The inner wall surface located within the second opening can be specifically as follows: Figure 3The part of the inner wall of the sample suction and discharge unit 101 shown in area A is based on this method, so that after each sample discharge from the sample suction and discharge unit 101, there will be a certain amount of liquid residue, but because of the large roughness and the relatively good consistency of the processing accuracy, the amount of liquid residue remaining on the inner wall at the second opening will be the same or similar, thereby improving the consistency of the sample suction and discharge unit 101 each time it performs a sample separation operation, and further improving the consistency of the test results obtained in subsequent sample tests. Here, the inner wall of the sample suction and discharge unit 101 located within the second opening refers to Figure 3 The inner wall at the corner of the opening shown extends inwardly for a certain distance (eg, 2-5 mm).

[0099] Fifth, if Figure 3 and Figure 4 As shown, unlike the conventional understanding, the outer wall near the second opening of the sample suction and discharge unit 101 is not as smooth as possible. The surface roughness of the outer wall outside the second opening of the sample suction and discharge unit 101 is greater than or equal to 0.3 microns. The outer wall outside the second opening can be specifically as follows: Figure 3 The second opening may be a portion of the outer wall of the sample suction and discharge unit 101 as shown in the area B. Figure 4 The opening on the side wall of the sample suction and discharge unit 101 shown in the area C shown in the figure can make the sample suction and discharge unit 101 have a certain amount of liquid residue after each sample discharge. However, due to the large roughness and relatively good consistency of processing accuracy, the amount of liquid residue remaining on the inner wall at the second opening will be the same or similar, thereby improving the consistency of the sample suction and discharge unit 101 in each sample separation operation, and further improving the consistency of the test results obtained in subsequent sample tests. Here, the outer wall of the sample suction and discharge unit 101 outside the second opening refers to Figure 3 The outer wall of the sample suction and discharge unit 101 of about 2-5 mm outside the corner of the opening is shown, and these outer walls form a complex curved surface shape similar to a circular ring around the opening.

[0100] Sixth, by providing a plurality of grooves on the outer wall of the sample suction and discharge unit 101, and extending along the axial direction of the sample suction and discharge unit 101, when the sample suction and discharge unit 101 penetrates into the container storing the sample, the air inside and outside the container can circulate through the grooves provided on the outer wall of the sample suction and discharge unit 101, so that during the process of the sample suction and discharge unit 101 entering the container and in the subsequent process of collecting the sample through the sample suction and discharge unit 101, the air pressure inside and outside the container can be kept as consistent as possible, thereby reducing the possibility of unstable air pressure, and further reducing the possibility of changes in the sample or damage to the container itself due to unstable air pressure, thereby improving the accuracy, stability and safety of sample detection.

[0101] Seventh, by making the minimum distance between the sample suction and discharge unit 101 and the part of the pipeline fixed at both ends of the first pipeline unit 108 less than 50 mm, the curved pipeline through which the sample in the sample suction and discharge unit 101 passes before entering the part of the pipeline fixed at both ends of the first pipeline unit 108 can have sufficient curvature, so that the sample can achieve a 180-degree turn in the sample flow path before entering the part of the pipeline fixed at both ends of the first pipeline unit 108. Due to the existence of pipe resistance and friction, it is equivalent to performing a depolymerization treatment on the sample based on pipe resistance and friction, reducing the negative impact of inconsistent polymerization parameters caused by different standing time of samples in different batches, improving the consistency of polymerization parameters of samples collected each time, and thereby improving the accuracy of subsequent detection of polymerization parameters and / or other parameters of the samples.

[0102] Eighth, by making the pipeline between the part of the pipeline fixed at both ends of the first pipeline unit 108 and the sample suction and discharge unit 101 as an interference reduction pipeline, at least part of the pipeline in the interference reduction pipeline is a curved pipeline. By setting the curved pipeline, the sample can change direction multiple times in the process of passing through the curved pipeline, so that the sample can be reduced before entering the part of the pipeline fixed at both ends of the first pipeline unit 108. The negative impact of inconsistent polymerization parameters caused by different standing time of different batches of samples is reduced, the consistency of the polymerization parameters of the samples collected each time is improved, and the accuracy of subsequent detection of polymerization parameters and / or other parameters of the samples is improved.

[0103] In one embodiment, both the sample suction unit 103 and the sample discharge unit 102 are plunger pumps.

[0104] And / or, the opening direction of the sample suction unit 103 connected to the seventh pipeline unit 114 and the opening direction of the first end of the sample discharge unit 102 are both arranged upward.

[0105] Specifically, it is particularly important in today's increasingly developed science and technology, with the trend of smaller equipment and micro-quantity of reagents. As a common hydraulic pump, the plunger pump not only saves reagents and samples, but also makes the results more accurate.

[0106] Furthermore, the repeatability of the plunger pump is less than or equal to 1%. This key indicator exceeds that of conventional dosing pumps such as diaphragm pumps, peristaltic pumps and electromagnetic dosing pumps, which not only saves reagents and samples, but also makes the results more accurate.

[0107] Furthermore, the accuracy of the plunger in the plunger pump is between 0.002 mm and 0.005 mm. As a common hydraulic pump, the performance and life of the plunger pump depend to a large extent on the accuracy of the plunger. The accuracy of the plunger not only affects the flow, pressure and working efficiency of the pump, but is also directly related to the wear and sealing performance of the pump body. Therefore, in the design and manufacturing process of the plunger pump, there are strict requirements on the accuracy of the plunger. The accuracy requirement of the plunger in the plunger pump is usually between 0.002 mm and 0.005 mm. This accuracy requirement is determined based on the outer diameter tolerance of the plunger, with the aim of ensuring that the gap between the plunger and the pump body is as small as possible to ensure the normal suction and discharge of the liquid, thereby maintaining the efficient operation of the plunger pump.

[0108] Since the plunger pump has the advantages of high rated pressure, compact structure, high efficiency and convenient flow regulation, by setting both the sample suction unit 103 and the sample discharge unit 102 as plunger pumps, the efficiency and accuracy of sample suction and discharge can be effectively improved.

[0109] Syringes or plunger pumps have high liquid addition accuracy. However, if bubbles enter, they are compressible or expandable. During the positive and negative pressure changes of the liquid, the bubbles are prone to compression and expansion. In order to ensure the throughput, time is often not reserved for the bubbles to recover. Then, due to the volume change of the bubbles during the aspiration or discharge, it is easy to cause inaccurate volume estimation during the aspiration or discharge, which in turn affects the accuracy of the aspiration or discharge.

[0110] By setting the opening direction of the sample suction unit 103 connected to the seventh pipeline unit 114 and the opening direction of the first end of the sample discharge unit 102 upward, when the sample suction unit 103 and the sample discharge unit 102 inhale, discharge or temporarily store the sample, the bubbles in the sample can be discharged along the upward opening direction, thereby reducing the possibility of bubbles accumulating in the sample suction unit 103 and the sample discharge unit 102, thereby reducing the possibility of bubbles having a negative impact on the sample itself or the accuracy of sample suction and exhalation, thereby improving the accuracy of sample detection.

[0111] In one embodiment, if Figure 1 As shown, the opening axis of the first end of the first three-way unit 104 and the opening axis of the second end of the first three-way unit 104 are both located on the target straight line.

[0112] And / or, the opening direction of the third end of the first three-way unit 104 is perpendicular to the target straight line.

[0113] Specifically, Figure 1As shown, the first end of the first three-way unit 104 is connected to the sample suction and discharge unit 101, the second end of the first three-way unit 104 is connected to the sample discharge unit 102 through the first on-off control unit 106, and the third end of the first three-way unit 104 is connected to the sample suction unit 103 through the second on-off control unit 107.

[0114] When controlling the sample suction unit 103 to suck in the sample through the sample suction and discharge unit 101, more emphasis is usually placed on improving the suction efficiency, while the accuracy requirement is lower. Therefore, the opening direction of the third end of the first three-way unit 104 can be made perpendicular to the target straight line. Even if the sample changes direction in the first three-way unit 104 during the suction process and the accuracy is reduced, it will not cause too much impact on the collection operation of the sucked sample.

[0115] When the sample discharge unit 102 is controlled to discharge the sample through the sample suction and discharge unit 101, a sample separation operation is usually required at this time. The sample separation operation has high requirements for accuracy, and the amount of sample discharged each time needs to be accurately controlled to be the expected amount. Therefore, the opening axis of the first end of the first three-way unit 104 and the opening axis of the second end of the first three-way unit 104 can be located on the same straight line, so that the liquid path deflection of the sample discharged by the sample discharge unit 102 when flowing through the first three-way unit 104 is small or eliminated, thereby avoiding the negative impact of the liquid path deflection on the estimation of the amount of the discharged sample, thereby improving the accuracy of the blood separation operation, and then improving the accuracy of the sample detection.

[0116] In one embodiment, an optical measuring device 115 is disposed outside at least part of the outer wall of the first pipeline unit 108. The optical measuring device 115 is used to heat and / or detect the sample at the measurement location. The heating power of the optical measuring device 115 during heating is 3W-15W, and / or the length of the heated pipeline is greater than or equal to 40 mm and less than or equal to 60 mm.

[0117] Specifically, in practice, when the sample suction unit 103 is controlled to suck in the sample to complete the collection operation, a sample that is the sum of 140 microliters of the erythrocyte sedimentation rate parameter (Erythrocyte Sedimentation Rate) test sample volume and 40-50 microliters of the blood routine test sample volume is usually sucked in. Subsequently, the head and tail parts of the collected sample can be enabled to improve the accuracy of sample testing.

[0118] Assuming that the sample volume for full-mode detection (i.e., the sum of the sample volumes required for all tests) is 200 microliters and the inner diameter of the tube is 1 mm, the length of the tube occupied by the full-mode detection sample is 254.78 mm. Since the heating device needs to block external light, the heated object is inside the heat source. However, if the length of the heat source also exceeds 200 mm, it will have a significant adverse effect on the overall layout. Therefore, a shorter heat source length can be used to heat the entire sample. However, if the heat source length is too short, the heat source will overheat, and the temperature difference will be too large to easily damage the pipeline. Therefore, considering that the heat source length is greater than 40 mm, the corresponding heating pipeline length can be greater than or equal to 40 mm, and the corresponding heating pipeline length is generally not suitable for exceeding 60 mm (to avoid significant adverse effects on the overall layout).

[0119] In one embodiment, according to the demand input, the component module needs to operate at 15-32°C, and the maximum heating power occurs at a low temperature of 15°C. The depolymerization and measurement time during operation is calculated as a minimum of 10 seconds, and the heat required to heat the newly inhaled sample to the target temperature is:

[0120] Q=c*m*Δt,

[0121] Among them, the specific heat capacity of the blood sample is c=4.2*10^3 J / (kg·℃), the mass of 200 microliters of blood sample is about 0.2g, and the temperature difference Δt is calculated based on the ambient temperature Ta=15℃ and the module temperature T=56℃, Δt=41K;

[0122] The required heat Q=46.9J can be calculated, and the power required for preheating P=W / t=4.69W.

[0123] Since the newly inhaled sample can be heated immediately after inhalation, the blood separation step before depolymerization may also take about 10 seconds. However, considering that the heat source (i.e., the two sections of the optical measuring device are exposed to the air, it can be considered to multiply by the minimum correction coefficient of 0.65, and round up to get a minimum power of 3W. Considering that appropriately increasing the heating power is conducive to accelerating the heating efficiency, it can be considered to multiply by an empirical redundancy coefficient of 3, and round up to get a maximum power of 15W.

[0124] In one embodiment, when the optical measuring device 115 is heating, the length of the pipe part for heating is 4-6 cm (i.e., 40-60 mm), the inner diameter of the pipe is 1 mm, the heating power is 3W-15W, for example, its specification is 12W / 12V, its maximum operating current is 1A, and its duty cycle is controlled by MCU PWM, its control frequency is <=1Khz, high level heating, low level disconnection, it is a one-way heating device (cannot be cooled to avoid condensed water affecting the circuit or optical components), so that the optical measuring device 115 can heat the sample within a reasonable range, reduce the possibility of sample denaturation or damage caused by excessively high heating power, and reduce the possibility of slow sample heating efficiency caused by too low heating power, resulting in the red blood cell sedimentation rate parameter due to temperature changes, affecting the sedimentation rate and thus causing a large deviation, thereby improving the reliability of the optical measuring device 115 in detection.

[0125] In one embodiment, when the first on-off control unit 106 and the second on-off control unit 107 are both turned on, the driving power of the sample suction unit 103 is the first power; when the first on-off control unit 106 is turned on and the second on-off control unit 107 is turned off, the driving power of the sample suction unit 103 is the second power, and the first power is less than the second power.

[0126] Specifically, when both the first on-off control unit 106 and the second on-off control unit 107 are turned on, the sample suction unit 103 does not need to be indirectly connected to the first three-way unit 104 through the sample discharge unit 102, but can be directly connected to the first three-way unit 104, and a relatively small first power can be provided. When the first on-off control unit 106 is turned on and the second on-off control unit 107 is turned off, the sample suction unit 103 can only be indirectly connected to the first three-way unit 104 through the sample discharge unit 102, and a relatively large second power can be provided. By making the first power smaller than the second power, the sample suction unit 103 can have the same or similar liquid suction capacity in the above two situations, thereby improving the consistency of the liquid suction capacity of the sample suction unit 103 in different situations.

[0127] In one embodiment, the combined parameter measurement device also includes a swab and a swab two-way valve. The swab is arranged on the sample suction and discharge unit. The sample suction unit 103 is also used to perform cleaning operations through the swab 116. The swab 116 has a first opening and a second opening. The second opening is used to connect to the waste liquid pool, wherein the first end or the second end of the sample suction unit 103 is connected to the first opening of the swab through the swab two-way valve.

[0128] Specifically, first, the sample suction unit 103 is also used to perform a cleaning operation through a swab 116 disposed on the sample suction and discharge unit 101, the swab 116 has a first opening and a second opening, the second opening is used to connect to the waste liquid pool, the first end of the sample suction unit 103 is connected to the third end of the second three-way unit 105 through the seventh pipeline unit 114, wherein the first end or the second end of the sample suction unit 103 is connected to the first opening. In one example, Figure 1 As shown, the first end of the sample suction unit 103 is connected to the first opening through a corresponding two-way valve. Figure 2 , Figure 2 is a structural schematic diagram of another embodiment of the combined parameter measurement device of the present application, such as Figure 2 As shown, the second end of the sample suction unit 103 is connected to the first opening through a corresponding two-way valve. When it is not necessary to aspirate or spit liquid through the sample suction unit 103 to control the swab 116 to perform a cleaning operation, the two-way valve can be controlled to close. When it is necessary to aspirate or spit liquid through the sample suction unit 103 to control the swab 116 to perform a cleaning operation, the two-way valve can be controlled to open. The specific control is performed according to needs and is not limited here.

[0129] In one embodiment, and / or, the combined parameter measurement device further includes a flow chamber 117, a flow chamber three-way joint 118 and a flow chamber two-way valve, and the sample discharge unit 102 is also used to perform sample auxiliary push operation on the flow chamber 117, the first end of the flow chamber three-way joint 118 is connected to the sample discharge unit 102 through the flow chamber two-way valve, the second end of the flow chamber three-way joint 118 is connected to the sample port of the flow chamber 117, and the third end of the flow chamber three-way joint 118 is connected to the sample source. Second, the sample discharge unit 102 is also used to perform sample auxiliary push operation on the flow chamber. After the sheath flow is constructed in a flow-type manner, when the sample is input to form a sample flow, it is usually necessary to provide the sample with a thrust greater than the subsequent thrust for maintaining the sample flow. Therefore, the sample discharge unit 102 can provide an auxiliary thrust to the sample to be input when the sample is input, so that the sample is subjected to the main thrust provided by the flow detection device itself where the flow chamber is located, and is also subjected to the effect of the auxiliary thrust, thereby achieving stable construction of the sample flow and improving the efficiency of sample flow formation and the accuracy of loss detection. For example, see Figure 5 , Figure 5 is a structural schematic diagram of another embodiment of the combined parameter measurement device of the present application, such as Figure 5As shown, the first end of the flow chamber three-way connector 118 is connected to the sample discharge unit 102 through a corresponding two-way valve, the second end of the flow chamber three-way connector 118 is connected to the sample port of the flow chamber 117, the third end of the flow chamber three-way connector 118 is connected to the sample source, the sheath liquid port of the flow chamber 117 is connected to the sheath liquid source, the liquid outlet of the flow chamber 117 is connected to the waste liquid pool, the sheath liquid source can continuously provide sheath liquid to the flow chamber to form a sheath flow, the sample source can continuously provide samples to the flow chamber to form a sample flow, and the sample discharge unit 102 can assist the sample source in pushing the sample into the flow chamber 117 to form a sample flow while the sample source outputs the sample.

[0130] In the description of the present application, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present application. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art may combine and combine the different embodiments or examples described in this specification and the features of the different embodiments or examples, without contradicting each other.

[0131] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In the description of this application, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0132] Any process or method description in a flowchart or otherwise described herein may be understood to represent a module, segment or portion of code that includes one or more executable instructions for implementing the steps of a specific logical function or process, and the scope of the preferred embodiments of the present application includes alternative implementations in which functions may not be performed in the order shown or discussed, including performing functions in a substantially simultaneous manner or in the reverse order depending on the functions involved, which should be understood by technicians in the technical field to which the embodiments of the present application belong.

[0133] The logic and / or steps represented in the flowchart or otherwise described herein, for example, can be considered as an ordered list of executable instructions for implementing the logical functions, and can be embodied in any computer-readable medium for use by an instruction execution system, device or apparatus (which can be a personal computer, server, network device or other system that can fetch instructions from the instruction execution system, device or apparatus and execute the instructions), or in combination with these instruction execution systems, devices or apparatuses. For the purpose of this specification, "computer-readable medium" can be any device that can contain, store, communicate, propagate or transmit a program for use by an instruction execution system, device or apparatus or in combination with these instruction execution systems, devices or apparatuses. More specific examples of computer-readable media (a non-exhaustive list) include the following: an electrical connection with one or more wires (electronic device), a portable computer disk box (magnetic device), a random access memory (RAM), a read-only memory (ROM), an erasable and programmable read-only memory (EPROM or flash memory), a fiber optic device, and a portable compact disk read-only memory (CDROM). In addition, the computer-readable medium may even be paper or other suitable medium on which the program is printed, since the program may be obtained electronically, for example, by optically scanning the paper or other medium and then editing, interpreting or processing in other suitable ways if necessary, and then stored in a computer memory.

[0134] The above description is only an implementation method of the present application, and does not limit the patent scope of the present application. Any equivalent structure or equivalent process transformation made using the contents of the present application specification and drawings, or directly or indirectly used in other related technical fields, are also included in the patent protection scope of the present application.

Claims

1. A combined parameter measurement device, characterized in that: It includes a sample suction and discharge unit, a sample discharge unit, a sample suction unit, a first three-way unit, a second three-way unit, a first on-off control unit, a second on-off control unit, a first pipeline unit, a second pipeline unit, a third pipeline unit, a fourth pipeline unit, a fifth pipeline unit, a sixth pipeline unit and a seventh pipeline unit; The first end of the sample suction and discharge unit is used as a liquid suction port or a liquid discharge port, and the second end of the sample suction and discharge unit is connected to the first end of the first three-way unit through the first pipeline unit; The second end of the first three-way unit is connected to the first end of the first on-off control unit through the second pipeline unit, and the second end of the first on-off control unit is connected to the first end of the sample discharge unit through the third pipeline unit; The third end of the first three-way unit is connected to the first end of the second on-off control unit through the fourth pipeline unit, the second end of the second on-off control unit is connected to the first end of the second three-way unit through the fifth pipeline unit, the second end of the sample discharge unit is connected to the second end of the second three-way unit through the sixth pipeline unit, and the sample suction unit is connected to the third end of the second three-way unit through the seventh pipeline unit.

2. The combined parameter measurement device according to claim 1, characterized in that: The sample suction and discharge unit is used to suck liquid through the suction port, or discharge liquid through the discharge port; the content of the sample suction unit is greater than the content of the sample discharge unit; Wherein, when the sample suction and discharge unit does not suck in the sample, the sample suction and discharge unit is driven by the sample suction unit to suck in the sample, And / or, when the sample aspiration and discharge unit has aspirated the sample, the sample aspiration and discharge unit is driven to discharge the sample only by the sample discharge unit.

3. The combined parameter measurement device according to claim 1, characterized in that: The content volume of the fourth pipeline unit, or the content volume of the fifth pipeline unit, or the sum of the content volumes of the fourth pipeline unit and the fifth pipeline unit is greater than a preset content volume value; wherein the preset content volume value is greater than or equal to 3 times the content volume of the sample discharge unit, and / or the preset content volume value is less than or equal to 2 times the content volume of the sample suction unit; and / or, the content of the sample intake unit is greater than or equal to 30 times the content of the sample discharge unit; And / or, when the first on-off control unit and the second on-off control unit are both controlled to be open, the driving power of the sample suction unit is the first power, and when the first on-off control unit is controlled to be open and the second on-off control unit is controlled to be closed, the driving power of the sample suction unit is the second power, and the first power is less than the second power.

4. The combined parameter measurement device according to claim 1, characterized in that: An optical measuring device is disposed outside at least a portion of the outer wall of the first pipeline unit; In the first pipeline unit, the sub-pipeline located between the measuring position of the optical measuring device and the first end of the first three-way unit is the first sub-pipeline unit, wherein the tube length of the first sub-pipeline unit is greater than or equal to 500 mm, and / or the inner tube diameter of the first sub-pipeline unit is less than or equal to 2 mm, And / or, in the first pipeline unit, the sub-pipeline located between the measuring position of the optical measuring device and the second end of the sample aspiration and discharge unit is a second sub-pipeline unit, wherein the tube length of the second sub-pipeline unit is greater than or equal to 80 mm.

5. The combined parameter measurement device according to claim 1, characterized in that: The first pipeline unit comprises a first non-measurement pipeline, a measurement pipeline and a second non-measurement pipeline which are connected in sequence, and an optical measurement device is provided on an outer wall of the measurement pipeline; The pipe material of the measuring pipeline is different from the pipe material of the first non-measuring pipeline and the pipe material of the second non-measuring pipeline, and / or the light transmittance of the measuring pipeline is greater than or equal to 90%, and the haze is less than or equal to 5%.

6. The combined parameter measurement device according to claim 1, characterized in that: The sample suction and discharge unit has a first opening and a second opening, wherein the first opening is located at the upper end of the sample suction and discharge unit, and the second opening is located at the lower end of the sample suction and discharge unit; The radial cross-sectional area of ​​the first opening is greater than the radial cross-sectional area of ​​the second opening, the first opening is connected to the first pipeline unit, and the second opening is used as the liquid suction port or the liquid discharge port; And / or, the second opening is arranged on a side wall of the sample suction and discharge unit; and / or, the content of the sample suction and discharge unit is less than or equal to half of the content of the sample discharge unit; And / or, the surface roughness of the inner wall of the sample suction and discharge unit located within the second opening is greater than or equal to 0.2 micrometers; And / or, the surface roughness of the outer wall of the sample suction and discharge unit outside the second opening is greater than or equal to 0.3 micrometers; And / or, a plurality of grooves are provided on the outer wall of the sample suction and discharge unit, and the grooves are extended along the axial direction of the sample suction and discharge unit; And / or, the minimum distance between the sample suction and discharge unit and the part of the pipeline fixed at both ends of the first pipeline unit is less than 50 mm; And / or, in the first pipeline unit, the pipeline between the part of the pipeline fixed at both ends of the first pipeline unit and the sample aspiration and discharge unit is a disturbance reduction pipeline, and at least part of the pipeline in the disturbance reduction pipeline is a curved pipeline.

7. The combined parameter measurement device according to claim 1, characterized in that: The sample suction unit and the sample discharge unit are both plunger pumps; And / or, the opening direction of the sample suction unit connected to the seventh pipeline unit and the opening direction of the first end of the sample discharge unit are both arranged upward.

8. The combined parameter measurement device according to claim 1, characterized in that: The opening axis of the first end of the first three-way unit and the opening axis of the second end of the first three-way unit are both located on the target straight line; And / or, the opening direction of the third end of the first three-way unit is perpendicular to the target straight line.

9. The combined parameter measurement device according to claim 1, characterized in that: An optical measuring device is disposed outside at least part of the outer wall of the first pipeline unit, and the optical measuring device is used to heat and / or detect the sample at the measurement location. The heating power of the optical measuring device during heating is 3W-15W. And / or, the length of the heated pipeline is greater than or equal to 40 mm and less than or equal to 60 mm.

10. The combined parameter measurement device according to claim 1, characterized in that: The combined parameter measurement device further comprises a swab and a swab two-way valve, wherein the swab is arranged on the sample suction and discharge unit, and the sample suction unit is also used for performing a cleaning operation through the swab, and the swab has a first opening and a second opening, and the second opening is used for connecting to a waste liquid pool, wherein the first end or the second end of the sample suction unit is connected to the first opening of the swab through the swab two-way valve; And / or, the combined parameter measurement device also includes a flow chamber, a flow chamber three-way connector and a flow chamber two-way valve; the sample discharge unit is also used to perform sample auxiliary operation on the flow chamber; the first end of the flow chamber three-way connector is connected to the sample discharge unit through the flow chamber two-way valve; the second end of the flow chamber three-way connector is connected to the sample port of the flow chamber; and the third end of the flow chamber three-way connector is connected to a sample source.

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