Abamectin aqueous solution and preparation method thereof

Abstract

The invention discloses an abamectin aqueous solution and a preparation method thereof. The abamectin aqueous solution comprises the following components: 2% of abamectin; 2%-5% of a cosolvent; 0.002% to 0.6% of a synergist; and the balance of water. The pesticide preparation does not contain any organic solvent and is environmentally friendly, the preparation method is simple, and the insecticidal effect of abamectin can be effectively improved.

Description

Technical Field

[0001] The invention belongs to the technical field of pesticides, and particularly relates to an avermectin aqueous solution and a preparation method thereof. Background Art

[0002] Avermectin, chemically known as Avermectins, is a 16-membered macrolide compound produced by fermentation of soil microorganism Streptomyces avermitilis, which has significant insecticidal, acaricidal and nematicidal activities. Avermectin interferes with the neurophysiological activities of pests and stimulates the release of γ-aminobutyric acid, thereby inhibiting the nerve conduction of arthropods, causing paralysis and death of insects.

[0003] At present, commercially available avermectin preparations mainly include solid dosage forms such as wettable powders and liquid dosage forms such as emulsifiable concentrates, microemulsions, and water emulsions. These preparations have played an important role in improving the effectiveness of pesticides, but they also have some limitations. In particular, liquid preparations often require the addition of organic solvents and surfactants during the preparation process, which not only increases costs but also may cause environmental pollution. Therefore, it is of practical application value to develop a new, environmentally friendly and efficient avermectin preparation that reduces the impact on the environment while maintaining or improving the insecticidal effect of pesticides. Summary of the invention

[0004] The invention specifically relates to an avermectin aqueous solution and a preparation method thereof. The aqueous solution does not contain any organic solvent, is environmentally friendly, and can effectively improve the insecticidal effect of avermectin.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] The first aspect of the present invention provides an avermectin aqueous solution, comprising the following raw materials in mass fractions: avermectin: 2%; cosolvent: 2%-5%; synergist: 0.002%-0.6%; and the balance is water.

[0007] As a further technical solution, the cosolvent is any one of glucose, gluconic acid, and gluconic acid ester.

[0008] As a further technical solution, the synergist is any one of cinnamon oil and tetramethylguanidine.

[0009] The second aspect of the present invention is to provide a method for preparing an avermectin aqueous solution, comprising the following steps:

[0010] (1) adding avermectin original drug and cosolvent into a solvent, and performing ultrasonication until completely dissolved, to prepare an avermectin saturated solution;

[0011] (2) Adding a synergist to the saturated solution of avermectin, stirring at a speed of 300-500 rpm for 20-50 min, and filtering to obtain an avermectin aqueous solution.

[0012] As a further technical solution, the solvent in step (1) is water.

[0013] Compared with the prior art, the present invention has the following beneficial effects:

[0014] 1. The avermectin aqueous solution of the present invention does not contain any organic solvent and is environmentally friendly.

[0015] 2. The preparation method of the avermectin aqueous solution of the present invention is simple and can effectively improve the insecticidal effect of avermectin. DETAILED DESCRIPTION

[0016] The technical solution of the present invention is described in detail with specific embodiments in combination with the following examples. It should be understood that the following examples are only used to illustrate the technical solution of the present invention, but not to limit the scope of the present invention.

[0017] Example 1

[0018] Formula: 2g avermectin, 4g glucose, 0.5g cinnamon oil, and make up to 100g with water.

[0019] Preparation method:

[0020] (1) 50 mL of water was placed in a reactor, and avermectin and glucose were added, and ultrasound was performed until they were completely dissolved to prepare an avermectin saturated solution;

[0021] (2) adding cinnamon oil to the saturated avermectin solution prepared in step (1), stirring at a speed of 300-500 rpm for 20-50 min, and filtering to obtain an avermectin aqueous solution.

[0022] Example 2

[0023] Formula: 2g avermectin, 2.5g gluconic acid, 0.3g tetramethylguanidine, and make up to 100g with water.

[0024] Preparation method:

[0025] (1) 50 mL of water was placed in a reactor, and avermectin and gluconic acid were added, and ultrasonication was performed until they were completely dissolved to prepare an avermectin saturated solution;

[0026] (2) adding tetramethylguanidine to the saturated avermectin solution prepared in step (1), stirring at a speed of 300-500 rpm for 20-50 min, and filtering to obtain an avermectin aqueous solution.

[0027] Example 3

[0028] Formula: 2g avermectin, 3g gluconate, 0.1g cinnamon oil, and make up to 100g with water.

[0029] Preparation method:

[0030] (1) 50 mL of water was placed in a reactor, and avermectin and gluconate were added, and ultrasonicated until completely dissolved to prepare an avermectin saturated solution;

[0031] (2) adding cinnamon oil to the saturated avermectin solution prepared in step (1), stirring at a speed of 300-500 rpm for 20-50 min, and filtering to obtain an avermectin aqueous solution.

[0032] Example 4

[0033] Formula: 2g avermectin, 5g glucose, 0.05g tetramethylguanidine, and make up to 100g with water.

[0034] Preparation method:

[0035] (1) 50 mL of water was placed in a reactor, and avermectin and glucose were added, and ultrasound was performed until they were completely dissolved to prepare an avermectin saturated solution;

[0036] (2) adding tetramethylguanidine to the saturated avermectin solution prepared in step (1), stirring at a speed of 300-500 rpm for 20-50 min, and filtering to obtain an avermectin aqueous solution.

[0037] Example 5

[0038] Formula: 2g avermectin, 3.5g gluconic acid, 0.4g cinnamon oil, and water to make up to 100g.

[0039] Preparation method:

[0040] (1) 50 mL of water was placed in a reactor, and avermectin and gluconic acid were added, and ultrasonication was performed until they were completely dissolved to prepare an avermectin saturated solution;

[0041] (2) adding cinnamon oil to the saturated avermectin solution prepared in step (1), stirring at a speed of 300-500 rpm for 20-50 min, and filtering to obtain an avermectin aqueous solution.

[0042] Example 6

[0043] Formula: avermectin 2g, gluconate 4.5g, tetramethylguanidine 0.25g, water to make up to 100g.

[0044] Preparation method:

[0045] (1) 50 mL of water was placed in a reactor, and avermectin and gluconate were added, and ultrasonicated until completely dissolved to prepare an avermectin saturated solution;

[0046] (2) adding tetramethylguanidine to the saturated avermectin solution prepared in step (1), stirring at a speed of 300-500 rpm for 20-50 min, and filtering to obtain an avermectin aqueous solution.

[0047] Comparative Example 1

[0048] The avermectin emulsifiable concentrate purchased from Chengdu Green Gold Biotechnology Co., Ltd. has an avermectin content of 1.8%.

[0049] Comparative Example 2

[0050] The avermectin suspension purchased from Zhengzhou Leading Chemical Co., Ltd. has an avermectin content of 5%.

[0051] Evaluation of control effect

[0052] (1) Clean water was used as a blank control. There were 4 treatment groups: the avermectin aqueous solution prepared in Examples 1 and 2, the commercially available avermectin emulsifiable concentrate in Comparative Example 1, and the commercially available avermectin suspension in Comparative Example 2, which were used to control Plutella xylostella. Each treatment group was repeated 4 times, with a total of 20 plots, each with an area of ​​20 m 2 ;

[0053] (2) The pesticide was sprayed at a dosage of 16 g / mu and 30 L of water per mu. Parallel jump sampling was performed 7, 14, and 21 days after the application of the pesticide. 25-50 cabbages were surveyed in each plot and the mortality rate was calculated. The blank control area was surveyed when the damage was obvious or when the damage was stable.

[0054] Calculation of control effect: Control effect (%) = [(number of insects in the control area - number of insects in the treatment area) / (number of insects in the control area)] × 100%

[0055] The control effect test results are shown in Table 1.

[0056] Table 1 Control effect on Plutella xylostella

[0057]

[0058] From the data in Table 1, it can be seen that from the average control effect 7 days, 14 days and 21 days after the application, 2% avermectin aqueous solution (treatment 1) has a better control effect on the cabbage diamondback moth, and the control effect of 2% avermectin aqueous solution (treatment 2) is higher 7 days after the application.

[0059] The above content is a further detailed description of the present invention in combination with specific implementation methods. It cannot be considered that the specific implementation of the present invention is limited to these descriptions. For ordinary technicians in the technical field to which the present invention belongs, simple modifications and substitutions made without departing from the concept of the present invention should be deemed to belong to the scope of protection of the present invention.

Claims

1. An avermectin aqueous solution, characterized in that: The invention comprises the following raw materials in mass fractions: avermectin: 2%; cosolvent: 2%-5%; synergist: 0.002%-0.6%; and the balance is water.

2. The avermectin aqueous solution according to claim 1, characterized in that The cosolvent is any one of glucose, gluconic acid, and gluconic acid ester.

3. The avermectin aqueous solution according to claim 1, characterized in that The synergist is any one of cinnamon oil and tetramethylguanidine.

4. A method for preparing an avermectin aqueous solution as claimed in any one of claims 1 to 3, characterized in that: The following steps are involved: (1) adding avermectin original drug and cosolvent into a solvent, and performing ultrasonication until completely dissolved, to prepare an avermectin saturated solution; (2) Adding a synergist to the saturated solution of avermectin, stirring at a speed of 300-500 rpm for 20-50 min, and filtering to obtain an avermectin aqueous solution.

5. The method for preparing the avermectin aqueous solution according to claim 4, characterized in that: The solvent in step (1) is water.

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