Method for improving pulmonary artery injury and aging caused by tobacco smoke

Abstract

The invention relates to the technical field of tobacco processing, and discloses a method for improving pulmonary artery injury and aging caused by tobacco smog, comprising the following steps: S1, fumigating tobacco leaves; s2, spraying a lung moistening agent; s3, tobacco leaf shredding; s4, spraying the spice liquid; s5, puffing the tobacco shreds; s6, cigarette paper preparation; and S7, cigarette preparation. The method comprises the following steps: fumigating tobacco leaves by using a fumigant prepared from methyl bromide, liquorice, clove, agastache rugosus, agilawood, rehmannia and platycodon grandiflorum; spraying a lung moistening agent prepared from a selenomethionine solution, a sodium selenite solution, tussilago farfara, black tea, adenophora stricta, poria cocos and fritillaria thun-bergli to the dampened tobacco leaves, so that the lung moistening agent is immersed into the tobacco leaves; spraying spice liquid prepared from a valerian extract, a red date extract, a dill seed extract, a nutmeg extract, a lavender extract, honey and edible essence on the tobacco shreds, and performing puffing treatment; the cigarette prepared by the method can reduce the influence of tobacco smoke on pulmonary artery injury and aging, and causes less functional damage to lung cells.

Description

Technical Field

[0001] The invention relates to the technical field of tobacco processing, in particular to a method for improving the aging of pulmonary artery damage caused by tobacco smoke. Background Art

[0002] The harmful components in tobacco smoke mainly include carcinogens, harmful gases that can cause harm to the respiratory system, and nicotine, which is highly addictive; therefore, smoking is one of the main causes of lung cancer; the various harmful substances contained in cigarette smoke can act as ligands, bind to the aromatase receptors highly expressed in the lungs, affect the expression of downstream genes cytochrome P450, and may also lead to the occurrence of lung cancer; in order to reduce the cell damage and aging caused by exogenous chemicals such as tobacco before the onset of tumors, it is necessary to improve the damage and aging of the pulmonary arteries caused by tobacco smoke.

[0003] A Chinese patent discloses a method for preparing expanded burley tobacco for low-tar flue-cured cigarettes (authorization announcement number CN101375735B). The expanded burley tobacco prepared by this patented technology has a low tar content and has a certain effect on alleviating lung damage, but its effect on alleviating aging of pulmonary artery damage is not obvious. Summary of the invention

[0004] The purpose of the present invention is to provide a method for improving the aging of pulmonary artery damage caused by tobacco smoke, so as to solve the problems raised in the above background technology.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] A method for improving tobacco smoke-induced pulmonary artery damage and aging, comprising the following steps:

[0007] S1. Tobacco fumigation: After the harvested tobacco leaves are cleaned, they are hung in a drying room and fumigated with fumigants for 36 to 48 hours. They are then naturally dried and fermented for later use.

[0008] S2. Spraying lung moisturizer: Slice the air-dried fermented tobacco leaves and rehydrate them to a moisture content of 16% to 19%, then spray the lung moisturizer on the sliced ​​tobacco leaves at a mass ratio of 1:(15 to 20), dry them to a moisture content of 19% to 22%, and store them at 50 to 60°C for 6 to 8 hours;

[0009] S3, shredding tobacco leaves: moistening the sliced ​​tobacco leaves with water vapor until the moisture content is 22% to 25%, shredding tobacco leaves to obtain shredded tobacco, and screening out tobacco leaf fragments, tobacco dust and tobacco stems;

[0010] S4. Spraying flavor liquid: Spray the flavor liquid on the tobacco at a mass ratio of 1:(10-12) and store at 50-60°C for 6-8h;

[0011] S5. Tobacco puffing: impregnate the tobacco with liquid carbon dioxide at 3-4 MPa for 5 minutes, then put it into a puffer and puff it at 240-280°C, and dry it to a moisture content of 10%-12% to obtain finished tobacco;

[0012] S6, preparation of cigarette paper: crushing the tobacco leaf fragments, tobacco dust and tobacco stems removed in step S4, separating the cellulose, bleaching and preparing pulp, and then pressing into cigarette paper;

[0013] S7, cigarette preparation: using a cigarette making machine to roll the finished tobacco shreds in step S4 into cigarette paper, and install a filter tip, and then package to obtain a finished cigarette.

[0014] As a further solution of the present invention: in the step S1, the fumigant is prepared from the following components by mass: 50-70 parts of methyl bromide, 8-10 parts of licorice, 8-10 parts of cloves, 4-6 parts of patchouli, 4-6 parts of agarwood, 3-5 parts of rehmannia and 3-5 parts of platycodon.

[0015] As a further solution of the present invention: the preparation method of the fumigant is as follows:

[0016] S11, take 8-10 parts of licorice, 8-10 parts of cloves, 4-6 parts of patchouli, 4-6 parts of agarwood, 3-5 parts of rehmannia and 3-5 parts of platycodon by weight, wash them respectively, soak them in 55-65° C. warm water for 1-1.5 h, filter out the fumigation raw materials, and obtain the soaking liquid for standby use;

[0017] S12, adding 10 to 15 times the weight of water to the filtered fumigation raw material, boiling it on low heat for 2 to 3 hours, filtering it, and obtaining a cooking liquid, repeating the operation 3 times, and combining the cooking liquids;

[0018] S13, the soaking liquid in step S2 and the cooking liquid in step S3 are combined and concentrated, and then dried at 55-60°C to a concentration of 1.1-1.2 g / cm 3 , obtaining a fumigation extract;

[0019] S14, taking 50 to 70 parts of methyl bromide and mixing them fully with the fumigation extract in step S13 to obtain a fumigant.

[0020] As a further scheme of the present invention: in the step S2, the lung moisturizing agent is prepared from the following components by mass: 30 to 40 parts of selenomethionine solution, 30 to 40 parts of sodium selenite solution, 10 to 15 parts of coltsfoot flowers, 8 to 10 parts of black tea, 3 to 5 parts of Adenophora radix, 3 to 5 parts of Poria cocos and 3 to 5 parts of Fritillaria thunbergii, wherein the concentrations of the selenomethionine solution and the sodium selenite solution are both 2 to 4 umol / L.

[0021] As a further solution of the present invention: the preparation method of the lung moistening agent is as follows:

[0022] S21, take 10-15 parts of coltsfoot flowers, 8-10 parts of black tea, 3-5 parts of Adenophora radix, 3-5 parts of Poria cocos and 3-5 parts of Fritillaria thunbergii by mass, wash them respectively, dry them at 45-50° C., grind them into powder, pass them through a 40-60 mesh sieve, and obtain lung moistening powder;

[0023] S22, defatting the lung-moistening powder with 95% ethanol by mass concentration, adding 120-150 parts of water, ultrasonically extracting at 60-70° C. to obtain a filtrate, and extracting three times;

[0024] S23, after the filtrate is combined, the protein is removed, the alcohol is precipitated, and the filter residue is filtered, and then washed with anhydrous ethanol, acetone, and ether in turn, and concentrated to a concentration of 1.1-1.2 g / cm 3 , obtaining a lung moistening extract;

[0025] S24, take 30-40 parts of selenomethionine solution with a concentration of 2-4 umol / L and 30-40 parts of sodium selenite solution with a concentration of 2-4 umol / L, and mix them thoroughly with the lung moistening extract in step S23 to obtain a lung moistening agent.

[0026] As a further solution of the present invention: in the step S4, the flavor liquid is mixed by the following components in parts by mass: 15 to 20 parts of valerian extract, 5 to 7 parts of red date extract, 5 to 8 parts of dill seed extract, 5 to 8 parts of nutmeg extract, 3 to 4 parts of lavender extract, 10 to 15 parts of honey and 8 to 10 parts of edible flavors.

[0027] As a further solution of the present invention: in the step S7, the filter is a composite filter made of acetate fiber, and is filled with 3% to 4% by weight of sodium hyaluronate.

[0028] Compared with the prior art, the present invention has the following beneficial effects:

[0029] The present invention first fumigates tobacco leaves with a fumigant made of methyl bromide, licorice, cloves, patchouli, agarwood, rehmannia root and platycodon; then sprays a lung moistening agent made of selenomethionine solution, sodium selenite solution, coltsfoot flower, black tea, adenophora, poria and fritillaria on the moistened tobacco leaves, so that the lung moistening agent is infiltrated into the tobacco leaves; then, a flavoring liquid made of valerian extract, red date extract, dill seed extract, nutmeg extract, lavender extract, honey and edible flavor is sprayed on the tobacco shreds for expansion treatment; the cigarettes prepared by the method can reduce the damage and aging effect of tobacco smoke on pulmonary arteries, and cause less functional damage to lung cells. DETAILED DESCRIPTION

[0030] Example 1

[0031] In an embodiment of the present invention, a method for improving tobacco smoke-induced pulmonary artery damage and aging includes the following steps:

[0032] S1. Tobacco fumigation: Take 8 parts of licorice, 8 parts of cloves, 4 parts of patchouli, 4 parts of agarwood, 3 parts of rehmannia and 3 parts of platycodon by weight, wash them respectively, put them into 55°C warm water and soak them for 1.5 hours, filter out the fumigation raw materials, and obtain soaking liquid; add 10 times the weight of water to the filtered fumigation raw materials, boil them on low heat for 2 hours, filter them, and obtain cooking liquid, repeat the operation 3 times, and combine the cooking liquid; then combine the soaking liquid and the cooking liquid and concentrate them, and then dry them at 55°C to a concentration of 1.1g / cm 3 , and obtain a fumigation extract; then take 50 parts of methyl bromide, and mix it with the fumigation extract to obtain a fumigant for standby use;

[0033] After the harvested tobacco leaves are cleaned, they are hung in a drying room and fumigated with fumigants for 36 hours, and then allowed to dry and ferment naturally.

[0034] S2. Spraying of lung moistening agent: Take 10 parts of coltsfoot flower, 8 parts of black tea, 3 parts of Adenophora radix, 3 parts of Poria cocos and 3 parts of Fritillaria thunbergii by mass, wash them respectively, dry them at 45°C, grind them into powder, and pass them through a 40-mesh sieve to obtain lung moistening powder; defatting the lung moistening powder with 95% ethanol by mass concentration, adding 120 parts of water, ultrasonically extracting at 60°C to obtain a filtrate, and extracting for 3 times; after combining the filtrates, remove protein, precipitate with alcohol, filter by suction, and then rinse the residue with anhydrous ethanol, acetone and ether in turn, and concentrate it to a concentration of 1.1 g / cm 3 , and obtain a lung moistening extract; then take 30 parts of a selenomethionine solution with a concentration of 2umol / L and 30 parts of a sodium selenite solution with a concentration of 2umol / L, and mix them thoroughly with the lung moistening extract to obtain a lung moistening agent for standby use;

[0035] The air-dried and fermented tobacco leaves were sliced ​​and rehydrated to a moisture content of 16%, and then lung moisturizer was sprayed on the sliced ​​tobacco leaves at a mass ratio of 1:15, and after drying to a moisture content of 19%, they were stored at 50°C for 8 hours;

[0036] S3, shredding tobacco leaves: moistening the sliced ​​tobacco leaves with water vapor until the moisture content is 22%, shredding tobacco leaves to obtain shredded tobacco, and screening out tobacco leaf fragments, tobacco dust and tobacco stems;

[0037] S4, spraying the flavor liquid: take 15 parts of valerian extract, 5 parts of red date extract, 5 parts of dill seed extract, 5 parts of nutmeg extract, 3 parts of lavender extract, 10 parts of honey and 8 parts of edible flavors by mass, mix them to obtain the flavor liquid for later use;

[0038] Then, the tobacco was sprayed with flavoring liquid at a mass ratio of 1:10 and stored at 50°C for 8 hours;

[0039] S5. Tobacco puffing: The tobacco is impregnated with liquid carbon dioxide at 3 MPa for 5 minutes, then put into a puffer for puffing at 240°C, and dried to a moisture content of 10% to obtain finished tobacco;

[0040] S6, preparation of cigarette paper: crushing the tobacco leaf fragments, tobacco dust and tobacco stems removed in step S4, separating the cellulose, bleaching and preparing pulp, and then pressing into cigarette paper;

[0041] S7, cigarette preparation: using a cigarette making machine to roll the finished tobacco in step S4 into cigarette paper, and install a acetate composite filter, and fill the inside of the acetate composite filter with 3% by weight of sodium hyaluronate, and obtain the finished cigarette after packaging.

[0042] Example 2

[0043] In an embodiment of the present invention, a method for improving tobacco smoke-induced pulmonary artery damage and aging includes the following steps:

[0044] S1. Tobacco fumigation: Take 9 parts of licorice, 9 parts of cloves, 5 parts of patchouli, 5 parts of agarwood, 4 parts of rehmannia and 4 parts of platycodon by weight, wash them respectively, put them into 60℃ warm water and soak them for 1.2h, filter out the fumigation raw materials, and obtain soaking liquid; add 12 times the weight of water to the filtered fumigation raw materials, boil them on low heat for 2.5h, filter them, and obtain cooking liquid, repeat the operation 3 times, and combine the cooking liquid; then combine the soaking liquid and the cooking liquid and concentrate them, then dry them at 58℃ to a concentration of 1.15g / cm 3 , and obtain the fumigation extract; then take 60 parts of methyl bromide, and mix it with the fumigation extract to obtain the fumigant for use;

[0045] After the harvested tobacco leaves are cleaned, they are hung in a drying room and fumigated with fumigants for 42 hours. After they are naturally dried and fermented, they are ready for use.

[0046] S2. Spraying of lung moistening agent: Take 12 parts of coltsfoot flower, 9 parts of black tea, 4 parts of Adenophora radix, 4 parts of Poria cocos and 4 parts of Fritillaria thunbergii by mass, wash them respectively, dry them at 48°C, grind them into powder, and pass them through a 50-mesh sieve to obtain lung moistening powder; defatting the lung moistening powder with 95% ethanol by mass concentration, adding 135 parts of water, ultrasonically extracting at 65°C to obtain a filtrate, and extracting for 3 times; after combining the filtrates, remove protein, precipitate with alcohol, filter by suction, and then rinse the residue with anhydrous ethanol, acetone and ether in turn, and concentrate it to a concentration of 1.15 g / cm 3 , and obtain a lung moistening extract; then take 35 parts of a selenomethionine solution with a concentration of 3umol / L and 35 parts of a sodium selenite solution with a concentration of 3umol / L, and mix them thoroughly with the lung moistening extract to obtain a lung moistening agent for standby use;

[0047] The air-dried and fermented tobacco leaves were sliced ​​and rehydrated to a moisture content of 17%, and then lung moisturizer was sprayed on the sliced ​​tobacco leaves at a mass ratio of 1:18, and after drying to a moisture content of 21%, they were stored at 55°C for 7 hours;

[0048] S3, shredding tobacco leaves: moistening the sliced ​​tobacco leaves with water vapor until the moisture content is 24%, shredding tobacco leaves to obtain shredded tobacco, and screening out tobacco leaf fragments, tobacco dust and tobacco stems;

[0049] S4, spraying the flavor liquid: take 18 parts of valerian extract, 6 parts of red date extract, 6 parts of dill seed extract, 7 parts of nutmeg extract, 3 parts of lavender extract, 12 parts of honey and 9 parts of edible flavors by mass, mix them to obtain the flavor liquid for later use;

[0050] Then, the tobacco was sprayed with the flavoring liquid at a mass ratio of 1:11 and stored at 55°C for 7 hours;

[0051] S5. Tobacco puffing: The tobacco is impregnated with liquid carbon dioxide at 3.5 MPa for 5 minutes, then put into a puffer and puffed at 260° C., and dried to a moisture content of 11% to obtain finished tobacco;

[0052] S6, preparation of cigarette paper: crushing the tobacco leaf fragments, tobacco dust and tobacco stems removed in step S4, separating the cellulose, bleaching and preparing pulp, and then pressing into cigarette paper;

[0053] S7, cigarette preparation: using a cigarette making machine to roll the finished tobacco in step S4 into cigarette paper, and install a acetate composite filter, and fill the inside of the acetate composite filter with 4% by weight of sodium hyaluronate, and obtain the finished cigarette after packaging.

[0054] Example 3

[0055] In an embodiment of the present invention, a method for improving tobacco smoke-induced pulmonary artery damage and aging includes the following steps:

[0056] S1. Tobacco fumigation: Take 10 parts of licorice, 10 parts of cloves, 6 parts of patchouli, 6 parts of agarwood, 5 parts of rehmannia and 5 parts of platycodon by weight, wash them respectively, put them into 65°C warm water and soak them for 1 hour, filter out the fumigation raw materials, and obtain soaking liquid; add 15 times the weight of water to the filtered fumigation raw materials, boil them on low heat for 3 hours, filter them, and obtain cooking liquid, repeat the operation 3 times, and combine the cooking liquid; then combine the soaking liquid and the cooking liquid and concentrate them, and then dry them at 60°C to a concentration of 1.2g / cm 3 , and obtain a fumigation extract; then take 70 parts of methyl bromide and mix it with the fumigation extract to obtain a fumigant for use;

[0057] After the harvested tobacco leaves are cleaned, they are hung in a drying room and fumigated with fumigants for 48 hours. After they are naturally dried and fermented, they are ready for use.

[0058] S2. Spraying of lung moistening agent: Take 15 parts of coltsfoot flower, 10 parts of black tea, 5 parts of Adenophora radix, 5 parts of Poria cocos and 5 parts of Fritillaria thunbergii by mass, wash them respectively, dry them at 50°C, grind them into powder, and pass them through a 60-mesh sieve to obtain lung moistening powder; defatting the lung moistening powder with 95% ethanol by mass concentration, adding 150 parts of water, ultrasonically extracting at 70°C to obtain a filtrate, and extracting for 3 times; after combining the filtrates, remove protein, precipitate with alcohol, filter by suction, and then rinse the residue with anhydrous ethanol, acetone and ether in turn, and concentrate it to a concentration of 1.2 g / cm 3 , and obtain a lung moistening extract; then take 40 parts of a selenomethionine solution with a concentration of 4umol / L and 40 parts of a sodium selenite solution with a concentration of 4umol / L, and mix them thoroughly with the lung moistening extract to obtain a lung moistening agent for standby use;

[0059] The air-dried and fermented tobacco leaves were sliced ​​and rehydrated to a moisture content of 19%, and then lung moisturizer was sprayed on the sliced ​​tobacco leaves at a mass ratio of 1:20, and after drying to a moisture content of 22%, they were stored at 60°C for 8 hours;

[0060] S3, shredding tobacco leaves: moistening the sliced ​​tobacco leaves with water vapor until the moisture content is 25%, shredding tobacco leaves to obtain shredded tobacco, and screening out tobacco leaf fragments, tobacco dust and tobacco stems;

[0061] S4, spraying the flavor liquid: 20 parts of valerian extract, 7 parts of red date extract, 8 parts of dill seed extract, 8 parts of nutmeg extract, 4 parts of lavender extract, 15 parts of honey and 10 parts of edible flavors by mass, mix to obtain the flavor liquid for later use;

[0062] Then, the tobacco was sprayed with the flavoring liquid at a mass ratio of 1:12 and stored at 60°C for 8 hours;

[0063] S5. Tobacco puffing: The tobacco is impregnated with liquid carbon dioxide at 4 MPa for 5 minutes, then put into a puffer and puffed at 280°C, and dried to a moisture content of 12% to obtain finished tobacco;

[0064] S6, preparation of cigarette paper: crushing the tobacco leaf fragments, tobacco dust and tobacco stems removed in step S4, separating the cellulose, bleaching and preparing pulp, and then pressing into cigarette paper;

[0065] S7, cigarette preparation: using a cigarette making machine to roll the finished tobacco in step S4 into cigarette paper, and install a acetate composite filter, and fill the inside of the acetate composite filter with 4% by weight of sodium hyaluronate, and obtain the finished cigarette after packaging.

[0066] In order to better illustrate the technical effect of the present invention, the following experiments are used to illustrate:

[0067] 1. Cell smoke exposure experiment:

[0068] Human pulmonary artery endothelial cell line (HPAEC) was selected and cultured at 37°C and divided into 5 groups, namely, Example 1 group, Example 2 group, Example 3 group, comparison group and blank group; cigarettes prepared in Examples 1 to 3 and commercially available flue-cured cigarettes (nicotine content in smoke: 1.0 mg, tar content: 10 mg, carbon monoxide content in smoke: 11 mg) were ignited respectively, and after the smoke concentration reached 20%, the smoke from the cigarettes prepared in Examples 1 to 3 was used to perform smoke poisoning on the human pulmonary artery endothelial cells in Example 1 group, Example 2 group and Example 3 group; the smoke from the commercially available flue-cured cigarettes was used to perform smoke poisoning on the human pulmonary artery endothelial cells in the comparison group, and the blank group was not treated in any way; wherein, 12 cigarettes were smoked in each group every day, and each smoking lasted for 3 seconds with an interval of 10 seconds, for 5 minutes.

[0069] One week later, the damage of lung cells was detected, and the indicators included cell viability (unit: 100%), cell apoptosis rate (unit: 100%) and cell proliferation rate (unit: 100%), and were recorded in Table 1 below.

[0070] Table 1 Analysis of lung cell damage

[0071]

[0072]

[0073] From Table 1 above, it can be concluded that the cell viability and cell proliferation rate in Example 1, Example 2 and Example 3 were significantly higher than those in the control group, and the cell apoptosis rate in Example 1, Example 2 and Example 3 was significantly lower than that in the control group; furthermore, it can be concluded that the cigarettes prepared by the present invention can reduce the influence of tobacco smoke on pulmonary artery damage and aging, and cause less functional damage to lung cells.

[0074] 2. Mouse lung damage test:

[0075] SD mice weighing 20 to 25 g were selected, raised at 25±1° C., exposed to natural light, and given sufficient drinking water and food. After one week, they were divided into 5 groups, namely, Example 1 group, Example 2 group, Example 3 group, a control group, and a blank group. The cigarettes prepared in Examples 1 to 3 and commercially available flue-cured cigarettes (nicotine content in flue gas: 1.0 mg, tar content: 10 mg, carbon monoxide content in flue gas: 11 mg) were ignited, and after the flue gas concentration reached 20%, the flue gas prepared in Examples 1 to 3 was used to smoke the SD mice in Example 1 group, Example 2 group, and Example 3 group. The commercially available flue-cured cigarettes were used to smoke the SD mice in Example 1 group, Example 2 group, and Example 3 group. The SD mice in the control group were smoked with the smoke after burning, and the blank group did not receive any treatment; each group smoked 12 cigarettes per day, with each smoking for 3 seconds and an interval of 10 seconds, lasting for 5 minutes; three months later, the lung damage of the mice was detected, and the indicators included serum total superoxide dismutase (T-SOD, unit: U / mL), malondialdehyde (MDA, unit: nmol / mL), glutathione peroxidase (GSH-PX, unit: enzyme activity unit), serum interleukin 6 (IL-6, unit: pg / mL) and tumor necrosis factor α (TNF-α, unit: pg / mL), and recorded in the following Table 2.

[0076] Table 2 Analysis of lung damage in mice

[0077]

[0078]

[0079] From Table 2 above, it can be concluded that the serum total superoxide dismutase and glutathione peroxidase in Example 1, Example 2 and Example 3 were significantly higher than those in the control group, and the malondialdehyde, serum interleukin 6 and tumor necrosis factor α in Example 1, Example 2 and Example 3 were significantly lower than those in the control group; furthermore, it can be concluded that the cigarettes prepared by the present invention can reduce the influence of tobacco smoke on pulmonary artery damage and aging, and cause less functional damage to lung cells.

[0080] What is described above is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A method for improving tobacco smoke-induced pulmonary artery damage and aging, characterized in that: The following steps are involved: S1. Tobacco fumigation: After the harvested tobacco leaves are cleaned, they are hung in a drying room and fumigated with fumigants for 36 to 48 hours. They are then naturally dried and fermented for later use. S2. Spraying lung moisturizer: Slice the air-dried fermented tobacco leaves and rehydrate them to a moisture content of 16% to 19%, then spray the lung moisturizer on the sliced ​​tobacco leaves at a mass ratio of 1:(15 to 20), dry them to a moisture content of 19% to 22%, and store them at 50 to 60°C for 6 to 8 hours; S3, shredding tobacco leaves: moistening the sliced ​​tobacco leaves with water vapor until the moisture content is 22% to 25%, shredding tobacco leaves to obtain shredded tobacco, and screening out tobacco leaf fragments, tobacco dust and tobacco stems; S4. Spraying flavor liquid: Spray the flavor liquid on the tobacco at a mass ratio of 1:(10-12) and store at 50-60°C for 6-8h; S5. Tobacco puffing: impregnate the tobacco with liquid carbon dioxide at 3-4 MPa for 5 minutes, then put it into a puffer and puff it at 240-280°C, and dry it to a moisture content of 10%-12% to obtain finished tobacco; S6, preparation of cigarette paper: crushing the tobacco leaf fragments, tobacco dust and tobacco stems removed in step S4, separating the cellulose, bleaching and preparing pulp, and then pressing into cigarette paper; S7, cigarette preparation: using a cigarette making machine to roll the finished tobacco shreds in step S4 into cigarette paper, and install a filter tip, and then package to obtain a finished cigarette.

2. A method for improving tobacco smoke-induced pulmonary artery damage and aging according to claim 1, characterized in that: In the step S1, the fumigant is prepared from the following components by mass: 50-70 parts of methyl bromide, 8-10 parts of liquorice, 8-10 parts of cloves, 4-6 parts of patchouli, 4-6 parts of agarwood, 3-5 parts of rehmannia and 3-5 parts of platycodon.

3. A method for improving tobacco smoke-induced pulmonary artery damage and aging according to claim 2, characterized in that: The preparation method of the fumigant is as follows: S11, take 8-10 parts of licorice, 8-10 parts of cloves, 4-6 parts of patchouli, 4-6 parts of agarwood, 3-5 parts of rehmannia and 3-5 parts of platycodon by weight, wash them respectively, soak them in 55-65° C. warm water for 1-1.5 h, filter out the fumigation raw materials, and obtain the soaking liquid for standby use; S12, adding 10 to 15 times the weight of water to the filtered fumigation raw material, boiling it on low heat for 2 to 3 hours, filtering it, and obtaining a cooking liquid, repeating the operation 3 times, and combining the cooking liquids; S13, the soaking liquid in step S2 and the cooking liquid in step S3 are combined and concentrated, and then dried at 55-60°C to a concentration of 1.1-1.2 g / cm 3 , obtaining a fumigation extract; S14, taking 50 to 70 parts of methyl bromide and mixing them fully with the fumigation extract in step S13 to obtain a fumigant.

4. The method for improving tobacco smoke-induced pulmonary artery damage and aging according to claim 1, characterized in that: In the step S2, the lung moisturizer is prepared from the following components by mass: 30 to 40 parts of selenomethionine solution, 30 to 40 parts of sodium selenite solution, 10 to 15 parts of coltsfoot flowers, 8 to 10 parts of black tea, 3 to 5 parts of Adenophora radix, 3 to 5 parts of Poria cocos and 3 to 5 parts of Fritillaria thunbergii, wherein the concentrations of the selenomethionine solution and the sodium selenite solution are both 2 to 4 umol / L.

5. A method for improving tobacco smoke-induced pulmonary artery damage and aging according to claim 4, characterized in that: The preparation method of the lung moistening agent is as follows: S21, take 10-15 parts of coltsfoot flowers, 8-10 parts of black tea, 3-5 parts of Adenophora radix, 3-5 parts of Poria cocos and 3-5 parts of Fritillaria thunbergii by mass, wash them respectively, dry them at 45-50° C., grind them into powder, pass them through a 40-60 mesh sieve, and obtain lung moistening powder; S22, defatting the lung-moistening powder with 95% ethanol by mass concentration, adding 120-150 parts of water, ultrasonically extracting at 60-70° C. to obtain a filtrate, and extracting three times; S23, after the filtrate is combined, the protein is removed, the alcohol is precipitated, and the filter residue is filtered, and then washed with anhydrous ethanol, acetone, and ether in turn, and concentrated to a concentration of 1.1-1.2 g / cm 3 , obtaining a lung moistening extract; S24, take 30-40 parts of selenomethionine solution with a concentration of 2-4 umol / L and 30-40 parts of sodium selenite solution with a concentration of 2-4 umol / L, and mix them thoroughly with the lung moistening extract in step S23 to obtain a lung moistening agent.

6. The method for improving tobacco smoke-induced pulmonary artery damage and aging according to claim 1, characterized in that: In the step S4, the flavor liquid is mixed by the following components in parts by mass: 15 to 20 parts of valerian extract, 5 to 7 parts of red date extract, 5 to 8 parts of dill seed extract, 5 to 8 parts of nutmeg extract, 3 to 4 parts of lavender extract, 10 to 15 parts of honey and 8 to 10 parts of edible flavors.

7. The method for improving tobacco smoke-induced pulmonary artery damage and aging according to claim 1, characterized in that: In the step S7, the filter tip is a composite filter tip made of acetate fiber and is filled with 3% to 4% by weight of sodium hyaluronate.

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