Aqueous humor drainage device and aqueous humor drainage device injection system

Abstract

The embodiments of the present application provide an aqueous humor drainage device and an aqueous humor drainage device push injection system. The aqueous humor drainage device includes a base body that passes through the corneal stroma from the anterior chamber to the corneoscleral limbus during use, and a limiting plate located outside the cornea; the base body includes a drainage part and a pulling part, the drainage part has a cavity with a tubular structure, the cavity has a liquid inlet and a liquid outlet, the pulling part includes one or more supporting bodies arranged on the flanks of the drainage part for limiting the position of the aqueous humor drainage device; the limiting plate is provided with a through hole, and the liquid outlet is connected to the through hole. The aqueous humor drainage device of the embodiment of the present application can effectively ensure the smooth flow of the filtration channel, and can fix the drainage device body through the supporting body, thereby improving the stability of the aqueous humor drainage device push injection.

Description

Technical Field

[0001] The present application relates to the field of medical device technology, and in particular to an aqueous humor drainage device and an aqueous humor drainage device push injection system. Background Art

[0002] Minimally Invasive Glaucoma Surgery (MIGS) is a general term for a type of surgical procedure. Compared with traditional anti-glaucoma surgery, it is less traumatic and safer. The surgery is performed through a tiny incision, has little impact on anatomy and physiology, has good implant biocompatibility, good intraocular pressure lowering effect, high safety, and short postoperative recovery time. Based on this, MIGS for glaucoma has become increasingly popular in recent years. MIGS can promote the drainage of aqueous humor through three different pathways: trabecular meshwork-Schlemm's canal, suprachoroidal space, and subconjunctival. Currently, the development of MIGS is mainly based on the following methods:

[0003] XEN treats glaucoma with the following approach and drainage path: internal implantation, subconjunctival space; the mechanism of action: the micro-fistula directly connects the anterior chamber with the subconjunctival cavity, increasing the drainage of aqueous humor; structural design features: made of glutaraldehyde cross-linked gelatin, the material is soft when in contact with water, 6mm long, 45mm inner diameter, 125mm outer diameter. The operation is simple, inserted from the inside of the cornea, i.e. the anterior chamber, with small wounds and low invasiveness, without exposing the subconjunctival incision, and very high requirements for the positioning and placement of the drainage tube; indications: for mild to moderate open-angle glaucoma, including those with previous surgical failures and ineffective treatment with a large number of drugs. It can be used alone or in combination with cataract phacoemulsification for refractory glaucoma and some patients with angle-closure glaucoma; contraindications: neovascular glaucoma, inflammatory phase in the eye or on the ocular surface, limbal stem cell failure and pregnant patients; complications: low intraocular pressure; filtration bleb acupuncture surgery.

[0004] PRESERFLO Microshunt glaucoma drainage device, its access method and drainage path are: external implantation, subconjunctival space; working principle: directly connect the anterior chamber and subconjunctival cavity to increase the drainage of aqueous humor; structural design features: made of ultra-pure medical grade poly (styrene-block isobutylene-block styrene), with side wing structure. Microshunt is 8.5mm long, with an inner diameter of 70um and an outer diameter of 350um. The side wing is 3.1mm away from the proximal end of the tube and 4.4mm away from the distal end, with a wingspan of 1.1mm. During implantation, an incision is made from the outside and inserted into the anterior chamber, which requires peeling of the conjunctiva, causing certain invasive damage, but external operation makes the surgery simpler; Indications: primary open-angle glaucoma, patients with uncontrollable intraocular pressure after maximum tolerated drug treatment and / or patients who must undergo surgery due to glaucoma progression, some patients with refractory glaucoma, or may play a role in diseases such as iridocorneal endothelial syndrome, uveitic glaucoma and neovascular glaucoma; Contraindications: Not suitable for angle-closure glaucoma, patients with previous failed filtration surgery; Complications: Hypotension; Filtering bleb acupuncture surgery.

[0005] iStent implantation, its approach and drainage path are: internal implantation, Schlemm tube; the working principle is: placed in the trabecular tissue between the iris and cornea, it can connect the anterior chamber and the scleral venous sinus, reduce the resistance of aqueous humor discharge, and make the aqueous humor flow smoothly into the scleral venous sinus; structural design features: titanium stent with heparin coating on the surface, weighing about 60 micrograms, 120 micron inner diameter, 0.5mm×0.25mm×1.0mm. Precision machining, the flow channel outlet is not a single outlet, and four auxiliary outlets are set up. The concave waist design in the middle is convenient for the instrument to fit and fix with the tissue; indications: used to treat mild to moderate primary open-angle glaucoma in adults; contraindications: angle-closure glaucoma, neovascular glaucoma, rapid increase in intraocular pressure, ocular inflammation, and diseases that cause episcleral venous hypertension, such as goiter, eye tumors, sw syndrome; irregular shape of the anterior chamber angle; complications: stent dislocation, occlusion, anterior chamber hemorrhage.

[0006] Hydrus implantation, its approach and drainage path are: internal implantation, Schlemm's canal; the working principle is: to expand the scleral canal sinus and reduce the resistance of aqueous humor drainage; structural design features: nickel-titanium alloy, about 8mm long, radial size about 240um. The structure is not easy to deform, and the stent is directly placed in the Schlemm's canal; indications: for the treatment of patients with mild to moderate primary open-angle glaucoma combined with cataract surgery, pseudoexfoliation glaucoma patients; contraindications: angle-closure glaucoma, secondary glaucoma, such as neovascular, uveitis, traumatic, steroid-induced and lens-induced glaucoma, glaucoma patients who have previously undergone ciliary body ablation, trabeculectomy and other ciliary body or scleral canal sinus injuries; complications: hyphema, nickel ion vascular wall toxicity, corneal punctate staining, corneal epithelial erosion, matrix edema, tissue adhesion.

[0007] CyPass micro-stent treatment has the following access and drainage pathways: suprachoroidal space; structural design features: polyamide; indications: adults, mild to moderate primary open-angle glaucoma (POAG), combined with cataracts; contraindications: glaucoma other than primary open-angle glaucoma, irregular chamber angle shape; complications: FDA Class I highest level recall, which may lead to disability or death.

[0008] In general, among the MIGS surgeries currently available, those that utilize the trabecular meshwork Schlemm's canal pathway include: iStent, which was approved by the FDA in 2012 and is suitable for patients with mild glaucoma. Its one-year efficacy is 33.7%, but its disadvantage is that the filtration channel is easily blocked. Those that utilize the supraciliary choroidal space access include iStent inject W, which was approved by the FDA in 2020 and there is currently no relevant literature report; Hydrus, approved by the FDA in 2018, with a 1-year effectiveness rate of 37.1%; iStent inject, approved by CE in 2010, with a 2-year effectiveness rate of 31.0%; CyPass Micro-Stent was withdrawn from the market in 2018. Its disadvantages are high risk of hypotony and obstruction of the filtration channel; SOLX gold shunt, launched in Canada, with a 5-year effectiveness rate of 35.8%; STARfloTMGlaucoma Implant was approved by CE in 2012, with a 2-year effectiveness rate of 38.5%; MINIjectTM, approved by CE in 2020, with a 6-month effectiveness rate of 39.1%. For drainage to the subconjunctiva, there are XEN Gel Stent, which was approved by the FDA in 2016. Its disadvantage is conjunctival scarring and its 1-year effectiveness rate is 36.3%; PRESERFLOTM MicroShunt, which was approved by the CE in 2012. Its disadvantage is conjunctival scarring and its 5-year effectiveness rate is 46.7%.

[0009] In summary, the common disadvantages of the MIGS surgical instruments that are currently available on the market, which use three drainage pathways, namely, trabecular meshwork-Schlemm canal, suprachoroidal space and subconjunctival drainage, are filtration channel obstruction, fibrosis, displacement of drainage devices, conjunctival scarring, etc., and their long-term effectiveness still needs to be further improved. In addition, in the prior art, the injection of drainage devices mostly depends on the experience of doctors, and it is difficult to effectively control the injection position and injection depth of the drainage devices. Summary of the invention

[0010] In view of this, an embodiment of the present application provides an aqueous humor drainage device to solve the above-mentioned technical problems existing in surgical instruments in the prior art, and at the same time provides an aqueous humor drainage device push injection system to effectively control the push injection position and push injection depth of the drainage device.

[0011] According to a first aspect of the present application, there is provided an aqueous humor drainage device, comprising:

[0012] The base is located in the anterior chamber during use and the stopper is located under the conjunctiva;

[0013] The base comprises a drainage part and a pulling part, wherein the drainage part has a tubular cavity, the cavity has a liquid inlet and a liquid outlet, and the pulling part comprises one or more supporting bodies arranged on the side wings of the drainage part for limiting the position of the aqueous humor drainage device;

[0014] The limiting plate is provided with a through hole, and the liquid outlet is communicated with the through hole.

[0015] In some embodiments, the portion between the liquid inlet and the liquid outlet of the cavity is a straight tube structure of equal diameter or a straight tube structure of variable diameter.

[0016] In some embodiments, the portion between the liquid inlet and the liquid outlet of the cavity is a mesh structure.

[0017] In some embodiments, a Tesla valve structure is formed at each intersection of the mesh structure.

[0018] In some embodiments, the portion between the liquid inlet and the liquid outlet of the cavity is a straight tube structure.

[0019] According to a second aspect of the present application, there is provided a push injection system for an aqueous humor drainage device, comprising the aqueous humor drainage device as described in the first aspect, and further comprising:

[0020] A push injection device, the push injection device comprising a housing portion, a drainage knife, a propulsion portion and a propulsion portion limiting device;

[0021] The outer shell portion includes a tapered tip and a straight tube body, wherein the tapered tip has an opening communicating with an inner cavity of the straight tube body;

[0022] The propulsion unit includes a propulsion rod, a propulsion handle arranged at the rear end of the propulsion rod, and an aqueous humor drainage device installation unit arranged at the end of the propulsion rod, wherein the aqueous humor drainage device installation unit has a limiting groove;

[0023] The drainage knife is arranged on one side of the opening position of the conical tip, the propulsion part limiting device is arranged in the outer shell part and is fixedly connected to the inner side surface of the outer shell part, the end of the propulsion rod passes through the propulsion part limiting device, is located inside the conical tip, and can extend out of the outer shell part from the opening of the conical tip under the action of thrust, the aqueous humor drainage device is arranged in the limiting groove of the aqueous humor drainage device mounting part and is parallel to the drainage knife, and the tail of the propulsion rod extends to the outside of the tail end of the outer shell part.

[0024] In some embodiments, it also includes tail wings arranged on both sides of the rear edge of the straight tube body and extending circumferentially.

[0025] In some embodiments, the aqueous humor drainage device mounting portion includes two supporting rods arranged opposite to each other, the inner side of the front end of the supporting rod is formed with a depression, and the depressions of the two supporting rods form a limiting groove;

[0026] The outer side of the front end of the supporting rod extends outward to form a protrusion, and gradually retracts from the front end to the rear end to form an inclined surface or an arc surface.

[0027] In some embodiments, a limiting ring is provided inside the opening of the conical tip, and the inner side surface of the limiting ring abuts against the protrusion.

[0028] In some embodiments, a propulsion limit tube is sleeved on the tail of the propulsion rod, an outer wall of the propulsion limit tube is provided with annular limit teeth, and an inner wall of the outer shell is provided with a limit foot that is clamped in a limit groove formed by adjacent annular limit teeth.

[0029] In some embodiments, a return spring is further included, wherein the return spring is sleeved on the propulsion rod, one end of the return spring is connected to one end of the propulsion limit tube, and the other end of the return spring is connected to the tail end of the propulsion part limit device.

[0030] In some embodiments, the entire shell portion or a portion corresponding to the connection between the return spring and the propulsion limit tube is a transparent tube.

[0031] The aqueous humor drainage device involved in the present application can effectively ensure the smooth flow of the filtration channel, and can fix the drainage device body through the support body, thereby improving the stability of the aqueous humor drainage device push injection. The push injection system of the aqueous humor drainage device of the embodiment of the present application can assist the aqueous humor drainage device in push injection, and the push injection depth can be accurately controlled without excessive reliance on the doctor's operating experience, thereby reducing the difficulty of the drainage device push injection and improving the universality of the drainage device.

[0032] It should be understood that the contents described in the Summary of the Invention are not intended to limit the key or important features of the embodiments of the present application, nor are they intended to limit the scope of the present application. Other features of the present application will become easily understood through the following description. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] The above and other features, advantages and aspects of the embodiments of the present application will become more apparent with reference to the following detailed description in conjunction with the accompanying drawings. The accompanying drawings are used to better understand the present solution and do not constitute a limitation of the present application. In the accompanying drawings, the same or similar reference numerals represent the same or similar elements, among which:

[0034] Figure 1 A schematic structural diagram of an aqueous humor drainage device according to the first embodiment of the present application is shown;

[0035] Figure 2 A schematic structural diagram of an aqueous humor drainage device according to the second embodiment of the present application is shown;

[0036] Figure 3 A schematic structural diagram of an aqueous humor drainage device according to Embodiment 3 of the present application is shown;

[0037] Figure 4 A schematic diagram of the cavity structure of the drainage portion of the aqueous humor drainage device according to the fourth embodiment of the present application is shown;

[0038] Figure 5 A schematic structural diagram of an aqueous humor drainage device push injection system according to Embodiment 5 of the present application is shown;

[0039] Figure 6 A schematic diagram showing a first perspective of the tip of an aqueous humor drainage device push injection system capable of implementing an embodiment of the present application;

[0040] Figure 7 A second perspective schematic diagram showing the tip of an aqueous humor drainage device push injection system capable of implementing an embodiment of the present application;

[0041] Figure 8 A third perspective schematic diagram of the tip of the aqueous humor drainage device push injection system capable of implementing the embodiment of the present application is shown. DETAILED DESCRIPTION

[0042] In order to make the purpose, technical solution and advantages of the embodiments of the present application clearer, the technical solution in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0043] In addition, the term "and / or" in this article is only a description of the association relationship between the associated objects, indicating that there can be three relationships. For example, A and / or B can represent: A exists alone, A and B exist at the same time, and B exists alone. In addition, the character " / " in this article generally indicates that the associated objects before and after are in an "or" relationship.

[0044] The embodiment of the present application provides an aqueous humor drainage device that can be used in minimally invasive glaucoma surgery. By injecting the aqueous humor drainage device of the embodiment of the present application into the anterior chamber of the eyeball, the aqueous humor in the anterior chamber is drained, which can effectively reduce intraocular pressure.

[0045] The aqueous humor drainage device of the embodiment of the present application includes: a base located in the anterior chamber during use and a limiting plate located under the conjunctiva; the base includes a drainage portion and a pulling portion, the drainage portion has a cavity with a tubular structure, the cavity has a liquid inlet and a liquid outlet, the pulling portion includes one or more supporting bodies arranged on the side wings of the drainage portion for limiting the aqueous humor drainage device; a through hole is opened on the limiting plate, and the liquid outlet is connected to the through hole.

[0046] Specifically, Figure 1 , which is a schematic diagram of the structure of the aqueous humor drainage device according to the first embodiment of the present application. Figure 1It can be seen that the aqueous humor drainage device of this embodiment includes a base 6a and a limiting plate 7a, wherein the base 6a includes a tubular drainage portion 61a and a wing-shaped pulling portion 62a, the top of the drainage portion 61a is a drainage port, the bottom of the drainage portion 61a is a liquid outlet, and the pulling portion 62a includes two symmetrical supporting bodies, which are respectively arranged on both sides of the drainage portion 62, one of which includes an arc segment, a bent connecting segment and a tensioning segment, one end of the arc segment is connected to one side of the drainage port, the other end of the arc segment is connected to one end of the bent connecting segment, the other end of the bent connecting segment is connected to one end of the tensioning segment, and the other end of the tensioning segment is connected to the side wall of the drainage portion 61a above the liquid outlet. The arc segments of the two parts are generally conical structures, which are convenient for pushing and injecting the aqueous humor drainage device, and the bent connecting segments of the two parts form depressions and protrusions on both sides, which can effectively limit the aqueous humor drainage device. The limiting plate 7a is a plate-like structure, and a through hole (not shown in the figure) is opened in the middle of the limiting plate 7a. The limiting plate 7a can prevent the aqueous humor drainage device from being further wedged under natural peristalsis. At the same time, the limiting plate 7a can stay under the conjunctiva to ensure the continuous discharge of aqueous humor.

[0047] Figure 2 A schematic structural diagram of an aqueous humor drainage device according to the second embodiment of the present application is shown. Figure 2 The structure diagram of the aqueous humor drainage device of another embodiment of the present application is shown. Figure 1 The structure of the aqueous humor drainage device shown is similar, including a base 6b and a limit plate 7b. The base 6b includes a tubular drainage portion 61b and a wing-shaped pulling portion 62b. In this embodiment, the pulling portion 62b only includes a bent connecting section, one end of which is connected to one side of the drainage port, and the drainage portion 61b and the pulling portion 62b are arrow-shaped as a whole.

[0048] The aqueous humor drainage device of the above-mentioned embodiment of the present application can effectively ensure the smooth flow of the filtration channel, and can fix the drainage device body through the support body, thereby improving the stability of the aqueous humor drainage device push injection.

[0049] In addition, as an optional embodiment of the present application, on the basis of the above embodiment, in order to better pull and fix the aqueous humor drainage device, the side wings of the drainage part are provided with a plurality of support bodies for limiting the position of the aqueous humor drainage device. Figure 3As shown, it is a schematic diagram of the structure of the aqueous humor drainage device of the third embodiment of the present application. In this embodiment, the base 6c includes a tubular drainage portion 61c and a wing-shaped pulling portion 62c, and the liquid outlet of the base 6c is connected to the through hole of the limit plate 7c. Among them, the drainage portion 61c and the wing-shaped pulling portion 62c of the base 6c constitute a feather-like structure. Specifically, the pulling portion 62c includes a plurality of support bodies inclined to both sides of the drainage portion 61c, and the inclination directions of the support bodies on the same side are consistent. In addition, in this embodiment, the drainage port of the base 6c can also be provided with a conical or quasi-conical tip structure for easy injection.

[0050] In addition, in order to prevent the drawn aqueous humor from flowing back, the portion between the liquid inlet and the liquid outlet of the cavity of the drainage part is a mesh structure. Figure 4 As shown, it is a schematic diagram of the cavity structure of the drainage part of the aqueous humor drainage device of the fourth embodiment of the present application. The cavity of the drainage part of the aqueous humor drainage device of this embodiment has a liquid inlet 8 and a liquid outlet 9, and a mesh structure distributed between the liquid inlet 8 and the liquid outlet 9. Among them, the mesh structure includes a plurality of repeated structures, each of which has a first liquid outlet channel 601 and a second liquid outlet channel 602, and the first liquid outlet channel 601 and the second liquid outlet channel 602 are connected, the first side channel 604 is connected between the liquid inlet of the first liquid outlet channel 601 and the liquid outlet of the second liquid outlet channel 602, the second liquid outlet channel 602 and the third liquid outlet channel 603 are connected, and the second side channel 605 is connected between the liquid inlet of the second liquid outlet channel 602 and the liquid outlet of the third liquid outlet channel 603, and so on, the subsequent side channels and liquid outlet channels are also arranged in this way to form a mesh structure, so that the liquid outlet channels are connected, the side channels are staggered, and the layout of staggered connection is compact and has good space utilization. At the same time, a Tesla valve structure is formed at the connection between the outlet channel of the mesh structure and the side channel (i.e., the intersection of the mesh structure), which can effectively prevent aqueous humor reflux. The shape of the Tesla valve structure in this embodiment can also be adjusted according to actual needs. For example, the side channel can be approximately semicircular or ear-shaped.

[0051] In addition, the portion between the liquid inlet and the liquid outlet of the cavity is set as a straight tube structure, which can also achieve the technical effect of draining out the aqueous humor.

[0052] Furthermore, optionally, the portion between the liquid inlet and the liquid outlet of the cavity is a straight tube structure of equal diameter or a straight tube structure of variable diameter, that is, the inner diameter of the cavity is constant, or can also be gradually variable, for example, gradually increasing from the liquid inlet to the liquid outlet, or can also be divided into multiple sections, each section having an inner diameter gradually increasing along the direction from the liquid inlet to the liquid outlet.

[0053] In addition, the applicant has found in practice that the inner diameter of the cavity ranges from 10 microns to 60 microns. If the diameter is too large, excessive drainage will lead to low intraocular pressure. If the diameter is too small, the drainage is insufficient, the intraocular pressure is not reduced enough, and the treatment effect is poor.

[0054] The above is a description of the aqueous humor drainage device of the embodiment of the present application. The following is a detailed description of the aqueous humor drainage device injection system of the present application in conjunction with a specific embodiment.

[0055] like Figure 5 As shown, it is a schematic diagram of the structure of the aqueous humor drainage device push injection system according to the fifth embodiment of the present application. The aqueous humor drainage device push injection system of this embodiment is used to push the aqueous humor drainage device in the above embodiment into the anterior chamber to drain the aqueous humor in the anterior chamber. Specifically, the aqueous humor drainage device push injection system includes an aqueous humor drainage device and a push injection device. The specific structure of the aqueous humor drainage device has been described in detail in the above embodiment, and will not be elaborated in this embodiment. In this embodiment, the push injection device 1 includes an outer shell 2, a drainage knife 3, a propulsion portion 4 and a propulsion portion limit device 5.

[0056] The outer shell 2 includes a conical tip 201 and a straight tube body 202, wherein the conical tip 201 has an opening connected to the inner cavity of the straight tube body 202, and the opening is located at the tip of the conical tip. The straight tube body 202 is a hollow tubular structure. In this embodiment, the straight tube body 202 is a straight tube structure with a straight radius, and the radius of the cone bottom of the conical tip 201 is the same as the radius of the straight tube body 202. Usually, the conical tip 201 and the straight tube body 202 are integrally formed.

[0057] The propulsion unit 4 includes a propulsion rod 401, a propulsion handle 402 disposed at the rear end of the propulsion rod 401, and an aqueous humor drainage device installation portion disposed at the end of the propulsion rod 401, wherein the aqueous humor drainage device installation portion has a limiting groove.

[0058] The push rod 401 in this embodiment passes through the inner cavity of the outer shell part 2, and the end of the push rod 401 is configured to pass through the opening of the conical tip 201. The push handle 402 serves as a force-bearing component of the push rod 401 and is fixedly connected to the push rod 401. When the thrust force applied to the push handle 402 is applied, the push rod 401 can be pushed to move in the inner cavity of the outer shell part 2 along the opening direction toward the conical tip 201.

[0059] The drainage knife 3 is arranged at one side of the opening position of the conical tip 201, and the propulsion part limiting device 5 is arranged in the shell part 2 and fixedly connected to the inner side surface of the shell part 2. The propulsion part limiting device 5 has a through hollow cavity, and the propulsion rod 401 passes through the hollow cavity and extends from the end of the propulsion part limiting device 5 to the opening of the conical tip 201. The end of the propulsion rod 401 passes through the propulsion part limiting device 5, is located inside the conical tip 201, and can extend out of the shell part 2 from the opening of the conical tip 201 under the action of thrust. The aqueous humor drainage device 10 is arranged in the limiting groove 403 of the aqueous humor drainage device mounting part 404 and is parallel to the drainage knife 3. The tail of the propulsion rod 401 extends to the outside of the tail end of the shell part 2.

[0060] Specifically, Figure 6 , Figure 7 , Figure 8 As shown, the side of the drainage knife 3 is a diamond-shaped structure, and the bottom of the drainage knife 3 is fixed at the opening position of the conical tip 201. In order to facilitate fixation, a reinforcing hoop 2011 can be provided at the opening position of the conical tip 201, and the drainage knife 3 is fixed at the opening position of the conical tip 201 through the reinforcing hoop 2011. The drainage knife 3 serves as a guide part of the aqueous humor drainage device push injection system, and is used to puncture the conjunctiva first, open a wound for the push injection of the aqueous humor drainage device 10, so that the aqueous humor drainage device 10 can enter the anterior chamber along the wound opened by the drainage knife 3 and stay at the corresponding position.

[0061] The propulsion part limiting device 5 is arranged in the shell part 2, and is used to limit the propulsion rod 401, so that the propulsion rod 401 can be extended and retracted along the hollow cavity of the propulsion part limiting device 5. The tail of the propulsion rod 401 is sleeved with a propulsion limiting tube 405. The propulsion part limiting device 5 and the propulsion limiting tube 405 are connected by a spring, the radius of the spring is greater than the radius of the hollow cavity of the propulsion part limiting device 5, the tail end of the spring and the propulsion part limiting device 5 are abutted, and the other end of the spring is connected to the end of the propulsion limiting tube 405. Under normal circumstances, the spring is at a natural length. When the propulsion rod 401 is advanced, the propulsion rod 401 moves along the hollow cavity of the propulsion part limiting device 5 toward the opening direction of the conical tip 201, and the propulsion limiting tube 405 moves with the propulsion rod. The propulsion part limiting device 5 is fixed in the shell part 2, and the propulsion part limiting device 5 and the propulsion limiting tube 405 jointly compress the spring, so that the spring generates elastic potential energy, and the deformed spring is conducive to the reset of the propulsion rod 401.

[0062] The aqueous humor drainage device mounting portion 404 of the push rod 401 includes two supporting rods (such as Figure 6As shown in the figure, a depression is formed on the inner side of the front end of the supporting rod, that is, there is a notch on the inner side of the front end of each supporting rod, and the depressions of the two supporting rods form a limiting groove 403, that is, the notches are spliced ​​to form the limiting groove 403. In addition, the outer side of the front end of the supporting rod extends outward to form a protrusion, and gradually retracts from the front end to the rear end to form an inclined surface or an arc surface. The whole of a single supporting rod forms a wedge-shaped structure, and one side of the wedge-shaped structure is a plane, and the surface opposite to the side is an inclined surface, and the depression is located at the side position of the plane. A gap is reserved between the two supporting rods, and the gap is connected to the bottom of the limiting groove 403, and the aqueous humor drainage device 10 can be set in the limiting groove 403.

[0063] The aqueous humor drainage device mounting portion 404 is fixedly connected to the push rod 401. In a non-use state, the aqueous humor drainage device mounting portion 404 is located in the opening of the conical tip 201. A limiting ring is provided inside the opening of the conical tip 201. The limiting ring may be a part of the reinforcing hoop 2011 or may be provided independently of the reinforcing hoop 2011. The inner side surface of the limiting ring abuts against the protruding portion of the supporting rod, thereby applying pressure to the supporting rod to press the two supporting rods together.

[0064] When not in use, the limiting groove 403 of the aqueous humor drainage device mounting portion 404 is located in the opening of the conical tip 201, and the limiting ring applies tangential pressure to the two supporting rods, pressing the two supporting rods together to generate a clamping force to hold the aqueous humor drainage device 10 in the limiting groove 403.

[0065] During use, the outer shell 2 is pushed to push the drainage knife 3 to pierce the conjunctiva outside the anterior chamber of the eyeball. After the drainage knife 3 is pushed into the predetermined position, the outer shell 2 is stopped from being pushed, and then the push rod 401 is pushed; as the push rod 401 is pushed, the limiting groove 403 of the aqueous humor drainage device mounting portion 404 passes through the opening of the conical tip 201 and extends out of the opening of the conical tip 201. The aqueous humor drainage device 10 located in the limiting groove 403 is still in a clamped state at this time. Since the aqueous humor drainage device 10 is close to the drainage knife 3. As the push rod 401 is pushed forward, the incision made by the drainage knife 3 passes through the conjunctiva outside the anterior chamber of the eyeball. As the push rod 401 is pushed, the supporting rod is freed from the restraint of the limiting ring. Under the action of its own elastic force, the supporting rod opens toward both sides of the limiting groove 403, and the gap between the supporting rods becomes larger. At the same time, the space of the limiting groove 403 becomes larger, and the aqueous humor drainage device 10 located in the limiting groove 403 falls off from the limiting groove 403 and stays in the anterior chamber of the eyeball, completing the push injection of the aqueous humor drainage device 10.

[0066] In addition, in order to facilitate pushing the push rod, extended tail wings are circumferentially arranged on both sides of the straight tube body tail of the shell part 2. During use, the index finger and the middle finger can be placed on the tail wing, and the thumb can be pressed on the push handle 402. Through the force between the index finger, the middle finger and the thumb, the push rod can be pushed along the cavity of the shell part to the tip of the shell part 2, and the aqueous humor drainage device 10 can be pushed without the help of other equipment.

[0067] In order to prevent the force applied to the propulsion handle 402 from being difficult to control, in this embodiment, the outer side wall of the propulsion limit tube 405 is provided with an annular limit tooth 4051 (see Figure 5 ), the annular limit tooth 4051 includes a plurality of segments, each segment of the limit tooth is in a circular ring shape, specifically, a plurality of annular grooves can be opened on the outer wall of the thrust limit tube 405 to form the annular limit tooth 4051, that is, the raised portion between adjacent annular limit grooves is the annular limit tooth 4051, and a limit foot 2021 is provided on the inner wall of the outer shell part to be clamped in the limit groove formed by the adjacent annular limit teeth 4051. The limiting foot 2021 is elastic and is a rigid part. When the propulsion rod 401 is pushed, the propulsion limiting tube 405 fixedly connected to the propulsion rod 401 moves together with the propulsion rod 401, and the limiting foot 2021 fixed on the inner wall of the outer shell remains stationary. Under the meshing action of the annular limiting tooth 4051 and the limiting foot 2021, a certain resistance is formed, so that the propulsion of the propulsion rod 401 is divided into multiple stages, each stage is that the limiting foot 2021 crosses an annular limiting tooth 4051, thereby effectively controlling the propulsion force and propulsion depth of the propulsion rod 401.

[0068] The limiting feet 2021 in this embodiment can be flexibly arranged, and it is not necessary to arrange the limiting feet 2021 in the limiting grooves formed by each adjacent annular limiting tooth 4051 .

[0069] As a preferred embodiment, the limiting feet 2021 can be divided into multiple groups, each group of limiting feet includes two limiting feet 2021, and the two limiting feet 2021 in each group are respectively located on both sides of the same annular limiting tooth 4051, which can achieve the positioning of the propulsion rod 401 to a certain extent. At the same time, according to the size of the resistance to be applied, the number of groups of limiting feet 2021 can be flexibly set, and they are not listed one by one here.

[0070] For the sake of ease of observation, the entire outer shell or the portion corresponding to the connection between the reset spring and the push limit tube is a transparent tube. Furthermore, a scale can be marked on the push rod 401 between the reset spring and the push limit tube to indicate the push depth of the push rod 401, which corresponds to the push depth of the aqueous humor drainage device 10, thereby facilitating the precise control of the push depth of the aqueous humor drainage device.

[0071] The aqueous humor drainage device push injection system of the embodiment of the present application can assist in the push injection of the aqueous humor drainage device, and the push injection depth can be accurately controlled without excessive reliance on the doctor's operating experience, thereby reducing the difficulty of the drainage device push injection and improving the universality of the drainage device.

[0072] The above specific implementations do not constitute a limitation on the protection scope of this application. It should be understood by those skilled in the art that various modifications, combinations, sub-combinations and substitutions can be made according to design requirements and other factors. Any modifications, equivalent substitutions and improvements made within the spirit and principles of this application should be included in the protection scope of this application.

Claims

1. A push injection system for an aqueous humor drainage device, comprising an aqueous humor drainage device, wherein the aqueous humor drainage device comprises a base located in the anterior chamber during use and a limiting plate located under the conjunctiva; the base comprises a drainage portion and a pulling portion, the drainage portion has a cavity with a tubular structure, the cavity has a liquid inlet and a liquid outlet, the pulling portion comprises one or more supporting bodies arranged on the side wings of the drainage portion for limiting the position of the aqueous humor drainage device; a through hole is provided on the limiting plate, and the liquid outlet is connected to the through hole; characterized in that Also includes: A push injection device, the push injection device comprising a housing, a drainage knife, a propulsion unit and a propulsion unit limiting device; The outer shell portion comprises a conical tip and a straight tube body, wherein the conical tip has an opening communicating with the inner cavity of the straight tube body, and a limiting ring is arranged inside the opening of the conical tip; The propulsion part includes a propulsion rod, a propulsion handle arranged at the rear end of the propulsion rod, and an aqueous humor drainage device installation part arranged at the end of the propulsion rod. The aqueous humor drainage device installation part includes two supporting rods arranged opposite to each other, a depression is formed on the inner side of the front end of the supporting rod, and the depressions of the two supporting rods form a limiting groove. The outer side of the front end of the supporting rod extends outward to form a protrusion, and gradually retracts from the front end to the rear end to form an inclined surface or an arc surface. The inner side surface of the limiting ring abuts against the protrusion. The drainage knife is arranged on one side of the opening position of the conical tip, the propulsion part limiting device is arranged in the outer shell part and is fixedly connected to the inner side surface of the outer shell part, the end of the propulsion rod passes through the propulsion part limiting device, is located inside the conical tip, and can extend out of the outer shell part from the opening of the conical tip under the action of thrust, the aqueous humor drainage device is arranged in the limiting groove of the aqueous humor drainage device mounting part and is parallel to the drainage knife, and the tail of the propulsion rod extends to the outside of the tail end of the outer shell part.

2. The push injection system according to claim 1, characterized in that It also includes tail wings which are arranged on both sides of the rear edge of the straight tube body and extend in the circumferential direction.

3. The push injection system according to claim 1, characterized in that A propulsion limiting tube is sleeved on the tail of the propulsion rod, an annular limiting tooth is arranged on the outer wall of the propulsion limiting tube, and a limiting foot which is clamped in a limiting groove formed by adjacent annular limiting teeth is arranged on the inner wall of the shell.

4. The push injection system according to claim 3, characterized in that: It also includes a return spring, which is sleeved on the propulsion rod, one end of the return spring is connected to one end of the propulsion limit tube, and the other end of the return spring is connected to the tail end of the propulsion part limit device.

Images