A hair loss prevention shampoo composition for inhibiting hair breakage and inhibiting scalp aging and a preparation method thereof

Abstract

The present application relates to the technical field of shampoo products, and particularly relates to a hair loss prevention shampoo composition for inhibiting broken hair and inhibiting scalp aging and a preparation method thereof.The shampoo composition comprises the following preparation raw materials: radix polygoni multiflori extract, black ganoderma extract, black sesame extract, ginseng extract, ginger extract, carum nigrum extract, sophora flavescens extract, collagen, hydrolyzed keratin, humectant, emollient, surfactant, thickening agent, chelating agent, pH regulator, preservative and water.The composition prepared by the present application has excellent stability and cleaning effect, can effectively inhibit broken hair and inhibit scalp aging, and also has hair loss prevention effect.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of shampoo products, in particular to a hair loss prevention shampoo composition for inhibiting hair breakage and scalp aging and a preparation method thereof. BACKGROUND

[0002] Shampoo, also known as hair shampoo or hair conditioner, is the most widely used hair care product and one of the most commonly used hair cosmetics. It is mainly used to clean the oil, sweat, cells, dust, microorganisms, styling product residues and bad smell on the scalp and hair, so as to keep the scalp and hair clean and beautiful.

[0003] At present, the research on shampoo products is more focused on the development of functional shampoo, which is endowed with rich functions such as inhibiting hair breakage, inhibiting scalp aging, preventing hair loss and dandruff control. Although many shampoo products on the market have rich functions, the strength of various functions is uneven, and it is difficult to balance the excellent inhibiting hair breakage, inhibiting scalp aging and hair loss prevention effect. Therefore, it is one of the technical problems to be solved to develop a shampoo with balanced inhibiting hair breakage, inhibiting scalp aging and hair loss prevention functions. SUMMARY

[0004] In view of the above technical problems, the present application provides a hair loss prevention shampoo composition for inhibiting hair breakage and scalp aging and a preparation method thereof.

[0005] Specifically, the hair loss prevention shampoo composition for inhibiting hair breakage and scalp aging comprises the following preparation raw materials: radix polygoni multiflori extract, black ganoderma lucidum extract, black sesame extract, ginseng extract, ginger extract, artemisia vulgaris extract, sophora flavescens extract, collagen, hydrolyzed keratin, humectant, emollient, surfactant, thickening agent, chelating agent, pH regulator, preservative and water. The addition of radix polygoni multiflori extract, black ganoderma lucidum extract, black sesame extract, ginseng extract, ginger extract, artemisia vulgaris extract, sophora flavescens extract and hydrolyzed keratin can endow the composition with excellent inhibiting hair breakage, inhibiting scalp aging and preventing hair loss effect. The addition of collagen, humectant and emollient can endow the composition with excellent moisturizing and emollient effect. The use of surfactant can endow the composition with excellent cleaning effect.

[0006] Further, the surfactant can be selected from anionic surfactant, nonionic surfactant or zwitterionic surfactant.

[0007] Further, the surfactant includes at least one of sodium cocoyl glycinate, TEA cocoyl glutamate, sodium myristoyl glutamate, sodium lauroyl glutamate, potassium cocoyl glycinate, palmitoyl glycine, alkyl glycoside, fatty alcohol polyoxyethylene ether, fatty alcohol polyoxyethylene ether sulfate, cocamidopropyl betaine.

[0008] Further, the anti-hair splitting and anti-skin aging hair loss prevention shampoo composition includes, in terms of mass percentage, 0.05-2% of radix polygoni multiflori extract, 0.05-1.8% of black ganoderma extract, 0.04-1.4% of black sesame extract, 0.03-1.2% of ginseng extract, 0.02-1.1% of ginger extract, 0.03-1.4% of artemisia vulgaris extract, 0.08-1.05% of sophora flavescens extract, 0.1-0.9% of collagen, 0.08-0.85% of hydrolyzed keratin, 4-12% of humectant, 6-14% of emollient, 8-22% of surfactant, 1-3% of thickening agent, 0.2-0.8% of chelating agent, 0.2-0.7% of pH regulator, 0.2-0.4% of preservative, and the balance of water.

[0009] Further, the surfactant is 2-4% of sodium cocoyl glycinate, 1-5.5% of TEA cocoyl glutamate, 2-4.5% of sodium lauroyl glutamate, 2-5% of potassium cocoyl glycinate, and 1-3% of cocamidopropyl betaine.

[0010] Further, the mass ratio of the black ganoderma extract and the hydrolyzed keratin is 2-4:1.

[0011] Further, the humectant includes at least one of propylene glycol, ethylene glycol, butylene glycol, glycerol, dextran, sodium hyaluronate and its salt, sorbitol.

[0012] Further, the emollient includes at least one of grape seed oil, avocado oil, tea seed oil, jojoba seed oil, dimethicone, caprylic / capric triglyceride.

[0013] Further, the thickening agent includes at least one of carbomer, carboxymethyl cellulose, lignin.

[0014] Further, the chelating agent includes at least one of citrate, EDTA and its salt.

[0015] Further, the pH regulator includes at least one of citric acid, sodium hydroxide, potassium hydroxide, acetic acid, tartaric acid, sodium bicarbonate, sodium carbonate, arginine.

[0016] Further, the preservative includes at least one of phenoxyethanol, benzoate.

[0017] Further, the preparation method of the polygonum multiflorum extract is as follows: the dried polygonum multiflorum is crushed to a particle size of less than 0.1 mm, 15-50 times the mass of an ethanol aqueous solution with a concentration of 20-42% is added, heated to 40-50 DEG C, stirred at 50-500 rpm for 5-10 hours, coarsely filtered through a filter membrane with a pore size of 0.5-20 microns, then filtered through an ultrafiltration membrane with a molecular weight cut-off of 1500 Da, and the filtrate is freeze-dried to obtain the polygonum multiflorum extract.

[0018] Further, the preparation method of the artemisia vulgaris extract is as follows: the dried artemisia vulgaris is crushed to a particle size of less than 0.5 mm, 12-40 times the mass of an ethanol aqueous solution with a concentration of 50-65% is added, heated to 42-55 DEG C, stirred at 70-1000 rpm for 6-15 hours, coarsely filtered through a filter membrane with a pore size of 0.2-20 microns, the filtrate is filtered through an ultrafiltration membrane with a molecular weight cut-off of 1000 Da, and the filtrate is freeze-dried to obtain the artemisia vulgaris extract.

[0019] Further, the preparation method of the ganoderma atrum extract is as follows: the dried ganoderma atrum is crushed to a particle size of less than 0.2 mm, 15-50 times the mass of water is added to obtain a mixture, then decocted at 80-85 DEG C, when the volume of the decocting liquid is 10%-30% of the volume of the mixture, water is added to the volume of the mixture, and decocted for 4-8 hours, then the decocting liquid is cooled to room temperature, coarsely filtered, then ultrafiltered through an ultrafiltration membrane with a molecular weight cut-off of less than 2000 Da, the filtrate is concentrated under reduced pressure, and the concentrate is freeze-dried to obtain the ganoderma atrum extract.

[0020] Further, the mass ratio of the polygonum multiflorum extract and the artemisia vulgaris extract is 1.2-2:1.

[0021] Further, the application further discloses a preparation method of the composition.

[0022] Step 1: the humectant, the surfactant, the thickening agent and water are added to water, heated and uniformly stirred;

[0023] Step 2: the emollient is continuously added, heated and uniformly stirred;

[0024] Step 3: cooled, then the polygonum multiflorum extract, the ganoderma atrum extract, the black sesame extract, the ginseng extract, the ginger extract, the artemisia vulgaris extract, the sophora flavescens extract, the collagen, the hydrolyzed keratin, the chelating agent, the pH regulator and the preservative are added, uniformly stirred, sterilized, and the composition is obtained.

[0025] Further, in step 1, the heating temperature is 40-50 DEG C, the stirring speed is 60-700 rpm, and the stirring time is 0.1-2 hours.

[0026] Further, the step 2, the temperature is 60-75℃, the stirring speed is 70-1000rpm, and the stirring time is 0.2-2 hours.

[0027] Further, the step 3, the temperature is 15-28℃, the stirring speed is 60-800rpm, and the stirring time is 0.2-1.5 hours.

[0028] Further, the step 3, the sterilization is pasteurization or ultraviolet sterilization.

[0029] The beneficial effects of the present application are as follows:

[0030] The composition prepared by the present application has excellent hair breakage inhibition and antioxidant effects, and has good stability, can impart hair anti-breakage and scalp anti-aging effects, and has good shelf life. Meanwhile, the polygonum multiflorum extract, black ganoderma extract, black sesame extract, ginseng extract, ginger extract, sophora flavescens extract, and keratin extract in the composition of the present application have hair loss prevention and anti-breakage effects, and can impart the composition with hair loss prevention and breakage prevention effects. The addition of collagen, humectants, and emollients makes the composition have excellent moisturizing and emollient effects. The use of the surfactants imparts the composition with excellent cleaning effects. The surfactants used, sodium cocoyl glycinate, TEA-cocoyl glutamate, sodium lauroyl glutamate, potassium cocoyl glycinate, and cocamidopropyl betaine, are detersive surfactants, which impart the composition with good hair cleaning effects.

[0031] The use of the black ganoderma extract and keratin in the present application can significantly improve the hair breakage inhibition effect of the composition; the mass ratio of the black ganoderma extract and keratin used in the preparation system of the present application is 2-4:1, which makes the composition have better hair breakage prevention effect.

[0032] The use of the polygonum multiflorum extract and artemisia carvifolia extract in the present application also has a certain promotion effect on hair breakage prevention.

[0033] The use of the polygonum multiflorum extract and artemisia carvifolia extract in the composition of the present application can impart the product with excellent antioxidant and anti-aging effects. In the composition obtained within the dosage ratio range of the present application, the polygonum multiflorum extract and artemisia carvifolia extract have a synergistic effect on promoting the antioxidant effect of the composition, and impart the composition with better anti-aging effect. And when the ratio of the two is 1.2-2:1, the anti-aging effect of the composition is better.

[0034] The composition of the present application has good effects, and the preparation method is simple, and has good application prospect. DETAILED DESCRIPTION

[0035] The present application will be described below in conjunction with specific embodiments, and various effects of the present application will be more clearly presented thereby. It should be understood by those skilled in the art that these specific embodiments are used to illustrate the present application, rather than limit the present application.

[0036] Unless otherwise specifically indicated, various materials, reagents, instruments and equipment and the like used in the present application can be purchased from the market or can be prepared by existing methods.

[0037] The raw materials used in the specific embodiments of the present application are as follows:

[0038] Black sesame extract: Shaanxi Xintianyue Biotechnology Co., Ltd. Ginseng extract: Nanjing Bemuda Biotechnology Co., Ltd. Ginger extract: Shaanxi Huinengda Biotechnology Co., Ltd. Sophora flavescens extract: Hebei Hongtao Biotechnology Co., Ltd. Collagen: Specifically, cod skin collagen, Klei Blue (Shaanxi) Biotechnology Co., Ltd. Hydrolyzed keratin: Hubei Xinyuhong Biomedicine Technology Co., Ltd. Grape seed oil: China Huano (Guangdong) Biomedicine Technology Co., Ltd. Avocado oil: Hubei Xinghengye Technology Co., Ltd. Tea seed oil: Wuhan Huaxiang Kejebio Technology Co., Ltd. Jojoba seed oil: Hubei Kemadi Chemical Co., Ltd.

[0039] The preparation method of the polygonum multiflorum extract is as follows: dry polygonum multiflorum is crushed to a particle size of less than 0.1 mm, 28 times the mass of an ethanol aqueous solution with a concentration of 28.5% is added, heated to 45℃, stirred at 72 rpm for 8.2 hours, coarsely filtered with a filter membrane with a pore size of 2 microns, then filtered with an ultrafiltration membrane with a molecular weight cut-off of 1500 Da, and the filtrate is freeze-dried to a water content of 5.27% to obtain the polygonum multiflorum extract.

[0040] The preparation method of the artemisia argyi extract is as follows: dry artemisia argyi is crushed to a particle size of less than 0.5 mm, 35 times the mass of an ethanol aqueous solution with a concentration of 62% is added, heated to 50℃, stirred at 80 rpm for 10.3 hours, coarsely filtered with a filter membrane with a pore size of 5 microns, the filtrate is filtered with an ultrafiltration membrane with a molecular weight cut-off of 1000 Da, and the filtrate is freeze-dried to a water content of 5.93% to obtain the artemisia argyi extract.

[0041] The preparation method of the ganoderma atrum extract is as follows: dry ganoderma atrum is crushed to a particle size of less than 0.2 mm, 24 times the mass of water is added to obtain a mixture, then decocted at 83℃, when the volume of the decoction liquid is 15% of the volume of the mixture, water is added to the volume of the mixture, and the decoction is carried out for a total of 7.2 hours, then the decoction liquid is cooled to room temperature, coarsely filtered, then ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 1200 Da, the filtrate is concentrated under reduced pressure at 60℃ to 10.8% of the volume of the filtrate, and the concentrate is freeze-dried to a water content of 5.03% to obtain the ganoderma atrum extract.

[0042] I. Preparation of shampoo composition

[0043] The prepared shampoo composition is named as product A, B, C, D, etc. in sequence. The specific preparation is as follows.

[0044] Product A:

[0045] The raw materials used in preparation, mass percentage: 0.8% of Radix Polygoni Multiflori extract, 0.6% of black Ganoderma lucidum extract, 0.45% of black sesame extract, 0.55% of ginseng extract, 0.3% of ginger extract, 0.5% of artemisia vulgaris extract, 0.4% of Sophora flavescens extract, 0.25% of collagen, 0.2% of keratin, 8.5% of moisturizing agent, 10.4% of emollient, 16.5% of surfactant, 2.1% of thickening agent, 0.5% of chelating agent, 0.4% of pH regulator, 0.3% of preservative and the balance of water.

[0046] The surfactant is 3% sodium cocoyl glycinate, 4% TEA-cocoyl glutamate, 3.5% sodium lauroyl glutamate, 4% potassium cocoyl glycinate and 2% cocamidopropyl betaine.

[0047] The moisturizing agent is 1,2-propanediol, ethylene glycol and glycerol, which are composed according to the mass ratio of 1:2.5:5.

[0048] The emollient is grape seed oil, avocado oil, tea seed oil, jojoba seed oil, which are composed according to the mass ratio of 2.4:2:3:3.

[0049] The thickening agent is carbomer-934.

[0050] The chelating agent is sodium citrate and EDTA-2Na, which are composed according to the mass ratio of 1:1.

[0051] The pH regulator is arginine.

[0052] The mass ratio of black Ganoderma lucidum extract and keratin is 3:1.

[0053] The mass ratio of Radix Polygoni Multiflori extract and artemisia vulgaris extract is 1.6:1.

[0054] The preparation method of product A is as follows:

[0055] Step 1: add the moisturizing agent, surfactant, thickening agent and water into water, heat to 45℃ and stir at 80 rpm for 0.5 hours, stir evenly;

[0056] Step 2: continue to add the emollient, heat to 67℃ and stir at 90 rpm for 0.5 hours, stir evenly;

[0057] Step 3: cool to room temperature, then add the extract of radix polygoni multiflori, the extract of black ganoderma, the extract of black sesame, the extract of ginseng, the extract of ginger, the extract of artemisia, the extract of sophora, collagen, keratin, chelating agent, pH regulator, preservative, 75 rpm stirring for 0.4 hours, stirring evenly, ultraviolet sterilization, to obtain the product A.

[0058] Product B:

[0059] The raw materials used in preparation, mass percentage: 0.71% extract of radix polygoni multiflori, 0.64% extract of black ganoderma, 0.3% extract of black sesame, 0.7% extract of ginseng, 0.4% extract of ginger, 0.59% extract of artemisia, 0.3% extract of sophora, 0.27% collagen, 0.16% keratin, 8% humectant, 10% emollient, 16% surfactant, 2% thickening agent, 0.45% chelating agent, 0.45% pH regulator, 0.35% preservative and the balance water.

[0060] The surfactant is 3.5% sodium cocoyl glycinate, 4.5% TEA-cocoyl glutamate, 3% sodium lauroyl glutamate, 3% potassium cocoyl glycinate and 2% cocamidopropyl betaine.

[0061] The humectant is 1,2-propanediol, ethylene glycol and glycerol, which are composed according to the mass ratio of 1:3:4.

[0062] The emollient is grape seed oil, avocado oil, tea seed oil and jojoba seed oil, which are composed according to the mass ratio of 3:2:2.5:2.5.

[0063] The thickening agent is carbomer-934.

[0064] The chelating agent is composed of sodium citrate and EDTA-2Na according to the mass ratio of 1:1.

[0065] The pH regulator is arginine.

[0066] The mass ratio of the extract of black ganoderma and keratin is 4:1.

[0067] The mass ratio of the extract of radix polygoni multiflori and the extract of artemisia is 1.2:1.

[0068] The preparation method of the product A is as follows:

[0069] Step 1: add the humectant, surfactant, thickening agent and water into water, heat to 45℃ and stir at 85 rpm for 0.4 hours, stirring evenly;

[0070] Step 2: continue to add the emollient, heat to 68℃ and stir at 100 rpm for 0.45 hours, stirring evenly;

[0071] Step 3: cool to room temperature, then add the extract of radix polygoni multiflori, the extract of black ganoderma, the extract of black sesame, the extract of ginseng, the extract of ginger, the extract of artemisia, the extract of sophora, collagen, keratin, chelating agent, pH regulator, preservative, 80 rpm stirring for 0.5 hours, stirring evenly, ultraviolet sterilization, to obtain the product B.

[0072] Product C:

[0073] The raw materials used in preparation, mass percentage: 1.3% extract of radix polygoni multiflori, 0.6% extract of black ganoderma, 0.45% extract of black sesame, 0.55% extract of ginseng, 0.3% extract of ginger, 0.4% extract of sophora, 0.25% collagen, 0.2% keratin, 8.5% humectant, 10.4% emollient, 16.5% surfactant, 2.1% thickening agent, 0.5% chelating agent, 0.4% pH regulator, 0.3% preservative and the balance of water. The others are the same as product A.

[0074] Product D:

[0075] The raw materials used in preparation, mass percentage: 0.6% extract of black ganoderma, 0.45% extract of black sesame, 0.55% extract of ginseng, 0.3% extract of ginger, 1.3% extract of artemisia, 0.4% extract of sophora, 0.25% collagen, 0.2% keratin, 8.5% humectant, 10.4% emollient, 16.5% surfactant, 2.1% thickening agent, 0.5% chelating agent, 0.4% pH regulator, 0.3% preservative and the balance of water. The others are the same as product A.

[0076] Product E:

[0077] The raw materials used in preparation, mass percentage: 0.45% extract of radix polygoni multiflori, 0.6% extract of black ganoderma, 0.45% extract of black sesame, 0.55% extract of ginseng, 0.3% extract of ginger, 0.85% extract of artemisia, 0.4% extract of sophora, 0.25% collagen, 0.2% keratin, 8.5% humectant, 10.4% emollient, 16.5% surfactant, 2.1% thickening agent, 0.5% chelating agent, 0.4% pH regulator, 0.3% preservative and the balance of water. The mass ratio of the extract of radix polygoni multiflori and the extract of artemisia is 0.53:1. The others are the same as product A.

[0078] Product F:

[0079] The raw materials used in the preparation, mass percentage: 1% of the extract of Radix Polygoni Multiflori, 0.6% of the extract of Ganoderma atrum, 0.45% of the extract of black sesame, 0.55% of the extract of ginseng, 0.3% of the extract of ginger, 0.3% of the extract of artemisia, 0.4% of the extract of Sophora flavescens, 0.25% of collagen, 0.2% of keratin, 8.5% of moisturizing agent, 10.4% of emollient, 16.5% of surfactant, 2.1% of thickening agent, 0.5% of chelating agent, 0.4% of pH regulator, 0.3% of preservative and the balance of water. The mass ratio of the extract of Radix Polygoni Multiflori and the extract of artemisia is 3.3:1. The others are the same as those of product A.

[0080] Product G:

[0081] The raw materials used in the preparation, mass percentage: 0.6% of the extract of Ganoderma atrum, 0.45% of the extract of black sesame, 0.55% of the extract of ginseng, 0.3% of the extract of ginger, 0.4% of the extract of Sophora flavescens, 0.25% of collagen, 0.2% of keratin, 8.5% of moisturizing agent, 10.4% of emollient, 16.5% of surfactant, 2.1% of thickening agent, 0.5% of chelating agent, 0.4% of pH regulator, 0.3% of preservative and the balance of water. The others are the same as those of product A.

[0082] Product H:

[0083] The raw materials used in the preparation, mass percentage: 0.8% of the extract of Radix Polygoni Multiflori, 0.45% of the extract of black sesame, 0.55% of the extract of ginseng, 0.3% of the extract of ginger, 0.5% of the extract of artemisia, 0.4% of the extract of Sophora flavescens, 0.25% of collagen, 8.5% of moisturizing agent, 10.4% of emollient, 16.5% of surfactant, 2.1% of thickening agent, 0.5% of chelating agent, 0.4% of pH regulator, 0.3% of preservative and the balance of water. The others are the same as those of product A.

[0084] Product I:

[0085] The raw materials used in the preparation, mass percentage: 0.8% of the extract of Radix Polygoni Multiflori, 0.4% of the extract of Ganoderma atrum, 0.45% of the extract of black sesame, 0.55% of the extract of ginseng, 0.3% of the extract of ginger, 0.5% of the extract of artemisia, 0.4% of the extract of Sophora flavescens, 0.25% of collagen, 0.4% of keratin, 8.5% of moisturizing agent, 10.4% of emollient, 16.5% of surfactant, 2.1% of thickening agent, 0.5% of chelating agent, 0.4% of pH regulator, 0.3% of preservative and the balance of water. The mass ratio of the extract of Ganoderma atrum and the extract of artemisia is 1:1. The others are the same as those of product A.

[0086] Product J:

[0087] The raw materials used for preparation, mass percentage: 0.8% of Radix Polygoni Multiflori extract, 0.72% of black Ganoderma lucidum extract, 0.45% of black sesame extract, 0.55% of ginseng extract, 0.3% of ginger extract, 0.5% of artemisia vulgaris extract, 0.4% of Sophora flavescens extract, 0.25% of collagen, 0.08% of keratin, 8.5% of moisturizing agent, 10.4% of emollient, 16.5% of surfactant, 2.1% of thickening agent, 0.5% of chelating agent, 0.4% of pH regulator, 0.3% of preservative and the rest of water. The mass ratio of the black Ganoderma lucidum extract and keratin is 9:1. The others are the same as those of product A.

[0088] II. Effect test

[0089] The above product was subjected to effect test.

[0090] 1. Test of hair breakage inhibition effect

[0091] The same individual and ex vivo hair of 15 cm in length was randomly divided into 11 bundles (corresponding to product A-J groups and a blank group), each weighing 0.5±0.01 g. The product A-J groups were treated with 0.25 mL of each product uniformly applied on the hair bundle, rubbed for 3 minutes, then washed with 37°C water and dried with a hair dryer, and the above-mentioned treatment was performed every 2 days for a total of 10 times. The blank group was treated with the same amount of water instead of the product, and the same treatment was performed. After the 10th treatment, 10 hairs of uniform thickness were randomly selected from each hair bundle, the two ends of the hair were fixed, and 10 hair stretching samples were prepared. Then the samples were placed on the sample holder of the MTT175 hair multifunctional tester, the stretching interval was adjusted to 30 mm, and the stretching speed was 12.5 mm / min. Then the test was performed, the hair was slowly stretched until it was pulled off, the stress Q (i.e. the maximum load of tensile fracture, unit: gf) when the hair was pulled off was recorded, and the operation was repeated 4 times. The Q value of each test group was counted, and the A value increase rate compared with the blank group was calculated. The results are shown in Table 1.

[0092] Table 1: Test of hair breakage inhibition effect

[0093] Test Q value / gf Q value increase rate compared to the blank group Product A 116.526±17.938 21.88％ Product B 115.975±15.427 21.31％ Product C 115.248±11.059 20.55％ Product D 113.946±18.372 19.19％ Product E 114.574±14.163 19.84％ Product F 115.017±10.764 20.31％ Product G 110.492±16.292 15.57％ Product H 102.879±11.824 7.61％ Product I 112.053±15.726 17.21％ Product J 109.421±13.478 14.45％ Blank group 95.604±10.265 /

[0094] 2. Anti-aging effect test

[0095] The anti-aging effect of the composition of the present application is verified by testing the in-vitro free radical scavenging effect. The testing method is as follows: DPPH is weighed in a 250 mL beaker, and a 95% volume concentration of ethanol aqueous solution is added to prepare a DPPH solution with a concentration of 0.12 mg / mL; the above product is diluted with deionized water to a product solution with a concentration of 0.05 mg / mL, 0.5 mL of which is mixed with 2.5 mL of the DPPH solution to serve as a test sample; 0.5 mL of anhydrous ethanol is mixed with 2.5 mL of the DPPH solution to serve as a blank group solution; the test sample and the blank group solution are placed in a dark room at room temperature for half an hour, and then the absorbance of each group at a wavelength of 517 nm is measured using a UV-visible spectrophotometer, which is the A value; each test is tested in triplicate, and the average value is taken, and then the DPPH free radical scavenging rate of each group is calculated, the calculation formula is as follows: DPPH free radical scavenging rate % = (blank group A value-test sample group A value) / blank group A value x 100%, and the results are shown in Table 2.

[0096] Table 2: In-vitro free radical scavenging effect test

[0097] Test DPPH radical scavenging rate Product A 95.42％ No delamination, no color change, no precipitation 94.73％ No delamination, no color change, no precipitation 88.91％ Product B 90.25％ No delamination, no color change, no precipitation 93.14％ No delamination, no color change, no precipitation 91.37％ Product C 72.69％ No delamination, no color change, no precipitation 84.37％

[0098] 3. Stability test

[0099] The above product is placed in an environment of 40°C for 3 months, and then taken out and cooled to room temperature, and the appearance of the product is observed for stratification, discoloration and precipitation, and the high-temperature resistance stability is tested.

[0100] The above product is placed in an environment of -10°C for 3 months, and then taken out and naturally warmed to room temperature, and the appearance of the product is observed for stratification, discoloration and precipitation, and the low-temperature resistance stability is tested.

[0101] The test results are shown in Table 3.

[0102] Table 3: Stability test

[0103] No delamination, no color change, no precipitation Product D No delamination, no color change, no precipitation No delamination, no color change, no precipitation Product E No delamination, no color change, no precipitation No delamination, no color change, no precipitation Product F No delamination, no color change, no precipitation No delamination, no color change, no precipitation Product G No delamination, no color change, no precipitation No delamination, no color change, no precipitation Product H No delamination, no color change, no precipitation No delamination, no color change, no precipitation Product I No delamination, no color change, no precipitation No delamination, no color change, no precipitation Product J No delamination, no color change, no precipitation No delamination, no color change, no precipitation Test High temperature stability Low temperature stability Product A No delamination, no color change, no precipitation No delamination, no color change, no precipitation Product B No delamination, no color change, no precipitation No delamination, no color change, no precipitation Product C No delamination, no color change, no precipitation No delamination, no color change, no precipitation Product D No delamination, no color change, no precipitation No delamination, no color change, no precipitation Product E No delamination, no color change, no precipitation No delamination, no color change, no precipitation Product F No delamination, no color change, no precipitation No delamination, no color change, no precipitation Product G No delamination, no color change, no precipitation No delamination, no color change, no precipitation Product H No delamination, no color change, no precipitation No delamination, no color change, no precipitation Product I No delamination, no color change, no precipitation No delamination, no color change, no precipitation Product J No delamination, no color change, no precipitation No delamination, no color change, no precipitation

[0104] From the test results of the products in Tables 1-3 above, it can be seen that the composition prepared in the application has excellent hair breakage inhibition and antioxidant effects, and has good stability, can impart the effects of preventing hair breakage and inhibiting scalp aging to hair, and has good shelf life. Meanwhile, the extracts of Radix Polygoni Multiflori, Heishigong extract, black sesame extract, ginseng extract, ginger extract, Sophora flavescens extract, and keratin in the composition of the application have the effects of preventing hair loss and preventing breakage, and can impart the effects of preventing hair loss and breakage to the composition. The addition of collagen, humectants, and emollients makes the composition have excellent moisturizing and emollient effects. The use of the surfactants imparts excellent cleaning effects to the composition. The surfactants used, sodium cocoyl glycinate, TEA-cocoyl glutamate, sodium lauroyl glutamate, potassium cocoyl glycinate, and cocamidopropyl betaine, are detersive surfactants, which impart good hair cleaning effects to the composition.

[0105] From the test results of products A and H in Table 1, it can be seen that the use of Heishigong extract and keratin in the application can significantly improve the effect of the composition on inhibiting hair breakage. From the test results of products A, B, I, and J, it can be seen that the mass ratio of Heishigong extract and keratin in products I and J is not within the range of 2-4:1 of the application, and the effect of preventing hair breakage is relatively poor. The mass ratio of Heishigong extract and keratin used in the preparation system of the application is 2-4:1, which makes the composition have better effects of preventing hair breakage.

[0106] Meanwhile, from the test results of products A and G in Table 1, it can be seen that the use of Radix Polygoni Multiflori extract and artemisia seed extract also has a certain effect of promoting hair breakage prevention.

[0107] From the test results of products A and G in Table 2, it can be seen that the use of Radix Polygoni Multiflori extract and artemisia seed extract in the composition of the application can impart excellent antioxidant and anti-aging effects to the product. And the effects of products C and D obtained under the condition that the amount of Radix Polygoni Multiflori extract or artemisia seed extract remains consistent are poorer than that of product A. Therefore, it can be seen that Radix Polygoni Multiflori extract and artemisia seed extract in the composition obtained within the amount ratio range of the application have a synergistic effect on promoting the antioxidant effect of the composition, and impart better anti-aging effects to the composition. And when the ratio of the two is 1.2-2:1, the anti-aging effect of the composition is better.

[0108] Obviously, those skilled in the art can make various modifications and variations to the application without departing from the spirit and scope of the application. Thus, if these modifications and variations of the application fall within the scope of the claims of the application and their equivalents, the application also intends to include these modifications and variations.

Claims

1. A hair loss prevention shampoo composition that inhibits hair breakage and scalp aging, characterized in that, The raw materials are as follows in terms of mass percentage: 0.05-2% polygonum multiflorum extract, 0.05-1.8% black ganoderma extract, 0.04-1.4% black sesame extract, 0.03-1.2% ginseng extract, 0.02-1.1% ginger extract, 0.03-1.4% artemisia sphaerocephala kraschen extract, 0.08-1.05% sophora flavescens extract, 0.1-0.9% collagen, 0.08-0.85% hydrolyzed keratin, 4-12% humectant, 6-14% emollient, 8-22% surfactant, 1-3% thickening agent, 0.2-0.8% chelating agent, 0.2-0.7% pH regulator, 0.2-0.4% preservative and the rest water; The mass ratio of black ganoderma extract to hydrolyzed keratin is 2-4:1; the mass ratio of polygonum multiflorum extract to artemisia sphaerocephala kraschen extract is 1.2-2:1; the surfactant includes at least one of sodium cocoyl glycinate, TEA-cocoyl glutamate, sodium myristoyl glutamate, sodium lauroyl glutamate, potassium cocoyl glycinate, palmitoyl glycine, alkyl glycoside, fatty alcohol polyoxyethylene ether, fatty alcohol polyoxyethylene ether sulfate and cocamidopropyl betaine; The humectant includes at least one of propylene glycol, ethylene glycol, butylene glycol, glycerol, dextran, sodium hyaluronate and its salt and sorbitol; the emollient includes at least one of grape seed oil, avocado oil, tea seed oil, jojoba seed oil, dimethicone and caprylic / capric triglyceride; The preparation method of polygonum multiflorum extract is as follows: the dried polygonum multiflorum is crushed to a particle size of less than 0.1 mm, 15-50 times mass of 20-42% ethanol aqueous solution is added, heated to 40-50°C, stirred at 50-500 rpm for 5-10 hours, coarsely filtered through a filter membrane with a pore size of 0.5-20 microns, then filtered through an ultrafiltration membrane with a molecular weight cut-off of 1500 Da, and the filtrate is freeze-dried to obtain the polygonum multiflorum extract; The preparation method of artemisia sphaerocephala kraschen extract is as follows: the dried artemisia sphaerocephala kraschen is crushed to a particle size of less than 0.5 mm, 12-40 times mass of 50-65% ethanol aqueous solution is added, heated to 42-55°C, stirred at 70-1000 rpm for 6-15 hours, coarsely filtered through a filter membrane with a pore size of 0.2-20 microns, the filtrate is filtered through an ultrafiltration membrane with a molecular weight cut-off of 1000 Da, and the filtrate is freeze-dried to obtain the artemisia sphaerocephala kraschen extract; The preparation method of black ganoderma extract is as follows: the dried black ganoderma is crushed to a particle size of less than 0.2 mm, 15-50 times mass of water is added to obtain a mixture, then the mixture is decocted at 80-85°C, when the volume of the decocting liquid is 10%-30% of the volume of the mixture, water is added to the volume of the mixture, and the mixture is decocted for 4-8 hours, then the decocting liquid is cooled to room temperature, coarsely filtered, then ultrafiltration is performed using an ultrafiltration membrane with a molecular weight cut-off of less than 2000 Da, the filtrate is concentrated under reduced pressure, and the concentrate is freeze-dried to obtain the black ganoderma extract; The surfactant is 2-4% sodium cocoyl glycinate, 1-5.5% TEA cocoyl glutamate, 2-4.5% sodium lauroyl glutamate, 2-5% potassium cocoyl glycinate and 1-3% cocamidopropyl betaine according to the mass percentage of the composition.

2. The anti-breakage, anti-aging of the scalp, anti-hair loss shampoo composition according to claim 1, wherein The thickening agent comprises at least one of carbomer, carboxymethyl cellulose, and lignin.

3. The anti-breakage, anti-aging of the scalp, anti-hair loss shampoo composition according to claim 1, wherein The chelating agent comprises at least one of citrate, EDTA and salts thereof.

4. The anti-breakage, anti-aging of the scalp, anti-hair loss shampoo composition according to claim 1, wherein The pH regulator comprises at least one of citric acid, sodium hydroxide, potassium hydroxide, acetic acid, tartaric acid, sodium bicarbonate, sodium carbonate, and arginine.

5. The anti-hair shedding, anti-senescence of the scalp, antidandruff shampoo composition according to claim 1, wherein The preservative comprises at least one of phenoxyethanol and benzoate.

6. A method of preparing an anti-hair loss shampoo composition for inhibiting hair breakage and inhibiting scalp aging according to any one of claims 1 to 5, characterized in that, The method comprises the following steps: Step 1: add the humectant, surfactant, thickening agent and water into water, heat and stir until uniform; Step 2: continue to add the emollient, heat and stir until uniform; Step 3: cool down, then add the extract of radix polygoni multiflori, extract of black ganoderma, extract of black sesame, extract of ginseng, extract of ginger, extract of artemisia carvifolia, extract of sophora flavescens, collagen, hydrolyzed keratin, chelating agent, pH regulator, preservative, stir until uniform, sterilize, and obtain the composition.

7. The production method according to claim 6, wherein In the step 1, the heating temperature is 40-50℃, the stirring speed is 60-700rpm, and the stirring time is 0.1-2 hours.

8. The production method according to claim 6, wherein In the step 2, the heating temperature is 60-75℃, the stirring speed is 70-1000rpm, and the stirring time is 0.2-2 hours.

9. The production method according to claim 6, wherein In the step 3, the cooling temperature is 15-28℃, the stirring speed is 60-800rpm, and the stirring time is 0.2-1.5 hours.