Indigo naturalis and moisturizing water honeyed pill and preparation method thereof

Abstract

The invention relates to the field of indigo naturalis and water-moistening honeyed pills, in particular to an indigo naturalis and water-moistening honeyed pill and a preparation method thereof, and the indigo naturalis and water-moistening honeyed pill comprises the following Chinese herbal medicines: indigo naturalis, baked ginger, oyster, radix rehmanniae, radix scrophulariae and moutan bark The traditional Chinese medicine composition comprises the following components in parts by weight: 200-400g of indigo naturalis; 300 to 600 g of baked ginger; the weight of the concha ostreae is 1000 to 2000g; 650g to 1300g of radix rehmanniae recen; 600 to 1200 g of radix scrophulariae; cortex moutan radicis: 450g to 900g; the indigo naturalis and water-moistening honeyed bolus provided by the invention shows a remarkable curative effect in the aspect of adjusting puberty precocious puberty large bone age, and the indigo naturalis, the baked ginger, the oyster, the radix rehmanniae, the radix scrophulariae and the moutan bark are scientifically proportioned to effectively regulate yin-yang balance in a body, clear away heat and toxic materials, nourish yin to lessen fire and promote blood circulation to remove blood stasis, so that the symptom of puberty precocious puberty large bone age caused by internal heat is improved.

Description

Technical Field

[0001] The invention relates to the field of Qingdai and Runshui honey pills, in particular to Qingdai and Runshui honey pills and a preparation method thereof. Background Art

[0002] Precocious puberty and advanced bone age are common developmental abnormalities in children, characterized by a bone age that is significantly ahead of the actual age, leading to abnormal early growth and development. This phenomenon is particularly evident in girls and may cause problems such as premature breast development and menarche, causing both psychological and physical distress to the children and their families.

[0003] Precocious puberty and advanced bone age can bring many harms to children, including: Physiological harm: Precocious puberty causes premature closure of bones, and the final height is shorter than normal. In addition, premature menarche in girls may lead to problems such as endometriosis, and premature testicular and penis development in boys may cause reproductive health problems; Psychological harm: Children with precocious puberty are prone to psychological discomfort and inferiority, especially when they appear "different" among their peers. This psychological pressure may lead to anxiety, depression and other problems; Social problems: Children with precocious puberty may face misunderstanding and discrimination from their peers and society, which may further aggravate their psychological pressure. In addition, premature sexual development also increases their risk of sexual assault.

[0004] According to TCM theory, the problem of high bone age in girls with precocious puberty is mostly caused by liver and kidney yin and yang imbalance. TCM believes that liver and kidney yin deficiency and kidney essence deficiency are the root cause, and qi stagnation, blood stasis, and endogenous phlegm are the symptoms. Treatment should focus on harmonizing the liver and kidney, nourishing essence and blood, and clearing phlegm and stasis in the body.

[0005] At present, the treatment methods for precocious puberty and advanced bone age mainly include the following, but each method has its limitations and inconveniences.

[0006] Hormone therapy:

[0007] GnRH analogs: GnRH analogs are the main method for treating central precocious puberty. They delay the progression of puberty by continuously inhibiting the pulsatile release of gonadotropin and reducing the secretion of sex hormones. Commonly used drugs include leuprorelin and triptorelin. These drugs are usually injected once a month. However, this treatment requires long-term injections, which brings inconvenience to children and their families. In addition, hormone therapy may cause side effects such as weight gain, mood swings, and headaches. The potential impact of long-term use on children's growth and development is not yet fully clear.

[0008] Histrelin implant: This approach can provide a sustained inhibitory effect for up to one year, reducing the need for frequent injections, but requires a minor surgery to place the implant under the skin of the upper arm, which needs to be removed or replaced after one year. The implantation and removal process may cause local pain and discomfort, and in some patients, the implant may break during removal, requiring further surgery.

[0009] Treat the underlying cause:

[0010] If precocious puberty is caused by another medical condition, such as a tumor that secretes sex hormones, the early onset of puberty can be prevented by treating the underlying condition. For example, removing the tumor that causes early puberty can stop the symptoms. However, this approach only works in cases where there is a clear cause. It is not suitable for most patients with precocious puberty who do not have a clear cause.

[0011] Chinese medicine conditioning:

[0012] Traditional Chinese medicine has a long history in China, and many prescriptions are used to regulate children's early developmental problems. However, there are also some significant disadvantages in traditional Chinese medicine conditioning, especially the problem that it is not suitable for adolescents and the complexity of medicinal materials. Traditional Chinese medicine prescriptions such as Zhibai Dihuang Decoction and Liuwei Dihuang Pills mainly regulate the balance of hormones in the body through the effects of nourishing yin and reducing fire, clearing away heat and detoxifying. However, the concentration and quality of the drugs in these prescriptions are difficult to stably control, affecting the treatment effect. And because of the complex composition of traditional Chinese medicine, some medicinal materials may have strong pharmacological effects and are not suitable for long-term use by adolescents, which may cause some side effects or adverse reactions.

[0013] Although modern Chinese medicine preparations can rationally mix a variety of Chinese medicinal materials and adopt modern drug preparation technology to solve some problems of traditional Chinese medicine, the number of relevant modern Chinese medicine preparations on the market is limited, and further clinical verification is needed to establish their long-term effects and safety. In addition, these preparations still have the problem of complex medicinal materials, and some ingredients may not be suitable for long-term use by adolescents.

[0014] Therefore, in view of the problems of complex medicinal materials, unsatisfactory long-term effects and safety of the above-mentioned related modern Chinese medicine preparations on the market, a Qingdai Herunshui honey pill and a preparation method thereof can be designed. Summary of the invention

[0015] In order to overcome the problems of complex medicinal materials, unsatisfactory long-term effects and safety of relevant modern Chinese medicine preparations on the market.

[0016] The technical solution of the present invention is: a Qingdai Herunshui honey pill, comprising the following Chinese herbal medicines: Qingdai, Paojiang, Oyster, Radix Rehmanniae, Scrophulariae and Paeonia Suffruticosa; the proportions by weight are as follows:

[0017] Indigo: 200g~400g;

[0018] Preserved ginger: 300g-600g;

[0019] Oysters: 1000g~2000g;

[0020] Raw land: 650g~1300g;

[0021] Scrophularia: 600g~1200g;

[0022] Peony bark: 450g~900g.

[0023] 2. A method for preparing a Qingdai and Runshui honey pill, comprising the Qingdai and Runshui honey pill described above, and the steps are as follows:

[0024] Step 1: Preliminary processing of oysters, Radix Rehmanniae, Scrophulariae and Paeonia Suffruticosa:

[0025] Crushing: Wash oysters, raw rehmannia, Scrophularia ningpoensis and Paeonia suffruticosa with clean water respectively, set the parameters of the crusher, and put them into the crusher for preliminary crushing;

[0026] Decoction: Boil the above medicinal materials and water in proportion for 10 to 15 minutes, then simmer for 2 hours over low heat, filter out the residue, and continue to boil the liquid to concentrate it;

[0027] Drying and pulverizing: Put the concentrated decoction into a dryer and dry it into powder. The total weight after drying is expected to be about 20% of the weight of the medicinal material;

[0028] Step 2: Processing of Indigo and Paojiang:

[0029] Put the indigo naturalis and the roasted ginger into a grinder for grinding respectively, grind the indigo naturalis and the roasted ginger into 300-400 mesh fine powder, seal and store for later use;

[0030] Step 3: Combination and granulation:

[0031] Mix all the dried medicinal material powders evenly, add appropriate amount of auxiliary materials, granulate by wet or dry method, sieve after drying, and make water-honey pills.

[0032] Preferably, in the preliminary processing of the medicinal materials in step 1, the parameters of the pulverizer are as follows: the crushing particle size is 20 to 100 meshes; and the crushing time is 30 to 50 seconds.

[0033] Preferably, the ratio of water to medicinal materials in step 1 decoction is 10:1.

[0034] Preferably, the auxiliary material added in step 3, combining and granulating, is one or any combination of honey, syrup, rice flour and starch.

[0035] Preferably, step three prepares water-honeyed pills, each weighing 0.5 g.

[0036] Beneficial effects of the present invention:

[0037] The Qingdai Herunshui honey pills of the present invention show significant therapeutic effects in regulating puberty precocious puberty and advanced bone age. Through the scientific proportion of Qingdai, Paojiang, oyster, Shengdi, Scrophularia and Paeonia suffruticosa, it can effectively regulate the balance of yin and yang in the body, clear away heat and detoxify, nourish yin and reduce fire, and promote blood circulation and remove blood stasis, thereby improving the symptoms of puberty precocious puberty and advanced bone age caused by internal heat.

[0038] Compared with traditional hormone therapy, Qingdai and Runshui Honey Pills have higher safety. Although hormone therapy is effective, it requires long-term injections or surgical implants, which may cause side effects such as weight gain, mood swings and headaches. Qingdai and Runshui Honey Pills avoid these side effects through the reasonable proportion and scientific processing of natural Chinese medicinal materials. In particular, Qingdai has shown a positive effect on bone metabolism in animal experiments, further proving its safety and effectiveness;

[0039] Traditional Chinese medicine prescriptions such as Zhibai Dihuang Decoction and Liuwei Dihuang Pills are effective, but usually require a long time to boil and are inconvenient to take, especially for children and teenagers. The present invention uses modern pharmaceutical technology to make Chinese medicine into a water-honeyed pill dosage form, each weighing 0.5 grams, which is convenient to take and suitable for long-term use. This dosage form is not only easy to take, but also can ensure the stability and consistency of the efficacy;

[0040] The preparation cost of Qingdai and Runshui honey pills is low, and they are suitable for large-scale production and promotion. Compared with hormone therapy and some high-priced Chinese medicine preparations, the preparations of the present invention are more economical and provide an affordable treatment option for the majority of patients;

[0041] Indigo and Runshui Honey Pills are not only effective in treating premature puberty and advanced bone age, but also have a variety of other TCM therapeutic effects. The herbs in the formula, such as oysters and raw earth, also have the effects of nourishing yin and kidney, consolidating essence and stopping leukorrhea, and help improve other health problems caused by yin deficiency and hyperactivity of fire, such as night sweats, hot flashes, insomnia, etc. In addition, this combination of herbs can enhance immunity, regulate the endocrine system, and promote overall health. DETAILED DESCRIPTION

[0042] The present invention will be further described below in conjunction with the embodiments.

[0043] Example 1

[0044] The present invention provides an embodiment: a Qingdai Herunshui honey pill, comprising the following Chinese herbal medicines: Qingdai, Paojiang, oyster, Shengdi, Scrophularia and Paeonia suffruticosa; the proportions by weight are as follows:

[0045] Indigo: 200g;

[0046] Preserved ginger: 300g;

[0047] Oysters: 1000g;

[0048] Raw land: 650g;

[0049] Scrophularia: 600g;

[0050] Peony bark: 450g.

[0051] 2. A method for preparing a Qingdai and Runshui honey pill, comprising the Qingdai and Runshui honey pill described above, and the steps are as follows:

[0052] Step 1: Preliminary processing of oysters, Radix Rehmanniae, Scrophulariae and Paeonia Suffruticosa:

[0053] Crushing: Wash oysters, raw rehmannia, Scrophularia ningpoensis and Paeonia suffruticosa with clean water respectively, set the parameters of the crusher, and put them into the crusher for preliminary crushing;

[0054] Decoction: Boil the above medicinal materials and water in proportion for 15 minutes, then simmer for 2 hours on low heat, filter out the residue, and continue to boil the liquid to concentrate;

[0055] Drying and pulverizing: Put the concentrated decoction into a dryer and dry it into powder. The total weight after drying is expected to be about 20% of the weight of the medicinal material;

[0056] Step 2: Processing of Indigo and Paojiang:

[0057] Put the indigo naturalis and the ginger into a grinder for grinding respectively, grind the indigo naturalis and the ginger into 300 mesh fine powder, seal and store for later use;

[0058] Step 3: Combination and granulation:

[0059] Mix all the dried medicinal material powders evenly, add appropriate amount of auxiliary materials, granulate by wet or dry method, sieve after drying, and make water-honey pills.

[0060] The Indigo and Runshui honey pills prepared by wet granulation in Example 1 are prepared by mixing dried medicinal material powder with liquid to form a wet mixture, which is then squeezed into wet granules by a granulator and then excess moisture is removed to make them into dry pellets. The Indigo and Runshui honey pills prepared in this way have uniform distribution of Chinese medicinal ingredients, high stability and hard texture, but a long preparation time.

[0061] Example 2

[0062] The present invention provides an embodiment: a Qingdai Herunshui honey pill, comprising the following Chinese herbal medicines: Qingdai, Paojiang, oyster, Shengdi, Scrophularia and Paeonia suffruticosa; the proportions by weight are as follows:

[0063] Indigo: 200g;

[0064] Preserved ginger: 300g;

[0065] Oysters: 1000g;

[0066] Raw land: 650g;

[0067] Scrophularia: 600g;

[0068] Peony bark: 450g.

[0069] 2. A method for preparing a Qingdai and Runshui honey pill, comprising the Qingdai and Runshui honey pill described above, and the steps are as follows:

[0070] Step 1: Preliminary processing of oysters, Radix Rehmanniae, Scrophulariae and Paeonia Suffruticosa:

[0071] Crushing: Wash oysters, raw rehmannia, Scrophularia ningpoensis and Paeonia suffruticosa with clean water respectively, set the parameters of the crusher, and put them into the crusher for preliminary crushing;

[0072] Decoction: Boil the above medicinal materials and water in proportion for 15 minutes, then simmer for 2 hours on low heat, filter out the residue, and continue to boil the liquid to concentrate;

[0073] Drying and pulverizing: Put the concentrated decoction into a dryer and dry it into powder. The total weight after drying is expected to be about 20% of the weight of the medicinal material;

[0074] Step 2: Processing of Indigo and Paojiang:

[0075] Put the indigo naturalis and the ginger into a grinder for grinding respectively, grind the indigo naturalis and the ginger into 400 mesh fine powder, seal and store for later use;

[0076] Step 3: Combination and granulation:

[0077] Mix all the dried medicinal material powders evenly, add appropriate amount of auxiliary materials, granulate by wet or dry method, sieve after drying, and make water-honey pills.

[0078] The Qingdai and Runshui honey pills prepared by dry granulation in Example 2 are prepared by directly pressing the dried medicinal material powder into pills. The operation steps are simple and the time is short. The Qingdai and Runshui honey pills prepared in this way have a relatively soft texture.

[0079] Scientific basis of formula and preparation:

[0080] Indigo: It has the effects of clearing away heat and detoxifying, cooling blood and removing spots. Modern research shows that it has a positive effect on bone metabolism.

[0081] Pao Jiang: warms the middle and dispels cold, harmonizes cold and heat, helps neutralize the coldness of Indigo, and protects the spleen and stomach.

[0082] Oysters: calm the nerves, strengthen the essence and stop diarrhea, are rich in calcium and are beneficial to bone development.

[0083] Shengdi: nourishes yin and reduces fire, cools blood and stops bleeding, can replenish yin fluid in the body and balance internal heat.

[0084] Scrophularia: clears heat and cools blood, nourishes yin and reduces fire, detoxifies and disperses nodules, and enhances the overall efficacy of the medicine.

[0085] Peony bark: clears heat and cools blood, promotes blood circulation and removes blood stasis, improves blood circulation and promotes drug absorption.

Claims

1. A Qingdai Herunshui honey pill, comprising the following Chinese herbal medicines: Qingdai, Paojiang, Oyster, Radix Rehmanniae, Scrophulariae and Paeonia Suffruticosa; the proportions by weight are as follows: Indigo: 200g~400g; Preserved ginger: 300g-600g; Oysters: 1000g~2000g; Raw land: 650g~1300g; Scrophularia: 600g~1200g; Peony bark: 450g~900g.

2. A method for preparing Indigo Naturalis and Runshui Honey Pills, characterized in that The method comprises the indigo and moistening water honey pills according to claim 1, wherein the steps are as follows: Step 1: Preliminary processing of oysters, Radix Rehmanniae, Scrophulariae and Paeonia Suffruticosa: Crushing: Wash oysters, raw rehmannia, Scrophularia ningpoensis and Paeonia suffruticosa with clean water respectively, set the parameters of the crusher, and put them into the crusher for preliminary crushing; Decoction: Boil the above medicinal materials and water in proportion for 10 to 15 minutes, then simmer for 2 hours over low heat, filter out the residue, and continue to boil the liquid to concentrate it; Drying and pulverizing: Put the concentrated decoction into a dryer and dry it into powder. The total weight after drying is expected to be about 20% of the weight of the medicinal material; Step 2: Processing of Indigo and Paojiang: Put the indigo naturalis and the roasted ginger into a grinder for grinding respectively, grind the indigo naturalis and the roasted ginger into 300-400 mesh fine powder, seal and store for later use; Step 3: Combination and granulation: Mix all the dried medicinal material powders evenly, add appropriate amount of auxiliary materials, granulate by wet or dry method, dry and sieve to make water-honey pills.

3. The Qingdai Herunshui honey pill and preparation method thereof according to claim 2, characterized in that: In the preliminary processing of the medicinal materials in step 1, the parameters of the pulverizer are as follows: the crushing particle size is 20 to 100 meshes; and the crushing time is 30 to 50 seconds.

4. The Qingdai Herunshui honey pill and preparation method thereof according to claim 2, characterized in that: In step 1, the ratio of water to medicinal materials during decoction is 10:

1.

5. The Qingdai Herunshui honey pill and preparation method thereof according to claim 2, characterized in that: In step 3, the auxiliary materials added in the merging and granulation are one or any combination of honey, syrup, rice flour and starch.

6. The Qingdai Herunshui honey pill and its preparation method according to claim 2, characterized in that: Step three: prepare water-honey pills, each weighing 0.5 g.