A traditional Chinese medicine composition for treating skin red, swollen, hot and painful lesions and a preparation method thereof

Abstract

The present application relates to the field of traditional Chinese medicine, and particularly provides a traditional Chinese medicine composition for treating skin redness, swelling, heat and pain, and a preparation method thereof. The composition is composed of two components, A and B. The component A contains isatis root, cortex lycii, pueraria, gardenia, sophora flavescens and giant knotweed. The component B contains radix trichosanthis, phellodendri, curcuma, rhubarb, radix angelicae dahuricae, magnolia officinalis, pericarpium citri reticulatae, atractylodes and licorice. The component A is decocted to obtain juice, and the component B is ground into powder and mixed uniformly. When used, a certain amount of the component A is mixed with a certain amount of the component B to form a paste, which is wrapped with single-layer gauze and applied to the pain site. After 1 hour, the paste is removed. The composition has the effects of clearing heat and resolving toxins, cooling blood and drying dampness, removing blood stasis and activating collaterals, and relieving swelling and pain. The combined use of the drugs has a remarkable effect on skin soft tissue redness, swelling, heat and pain caused by gout, skin soft tissue infection, fracture and sprain.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of new Chinese medicine, in particular to a kind of Chinese medicine composition for treating skin redness and swelling hot pain-like lesions and preparation method. BACKGROUND

[0002] Skin soft tissue redness and swelling hot pain-like lesions caused by gout, skin soft tissue infection, fracture, sprain and the like are a kind of more common skin soft tissue pathological changes, which are often red and swollen and painful in clinic, and secondary damage such as infection, lesion area enlargement and disease aggravation can be caused if not treated in time, which seriously affects the psychological state and daily life of patients. The etiology and pathogenesis are different with different diseases: among them, gout is caused by deposition of uric acid crystals in the joints at the end of limbs due to elevated uric acid, which stimulates the surrounding soft tissue to appear redness and swelling hot pain and the like; skin soft tissue infection is mostly caused by local bacterial infection of skin, which causes inflammatory response, redness and swelling hot pain, secretion of purulent secretions and the like; fracture and sprain are mostly caused by trauma, and local tissue damage after injury, local hyperemia, edema and pain, and more often combined with infection if it is an open wound.

[0003] "Sprain of the Lingshuo: "Rongqi remains in the meridians, blood cries and does not go, does not go, Weiqi follows and does not pass, block and cannot go, so hot. Big heat does not stop, hot and rotten, rotten and pus. "It is proposed that the blood vessels of the body are blocked, and the blood is not smooth, which causes heat and pus. "Lingshuo: Meridians" says: "bone is dry, vein is Ying, muscle is hard, meat is wall. "Lingshuo: evil guest" says: "Yingqi is to secrete its body fluid, inject it into the vein, and turn it into blood to nourish the four ends, and inject it into the five internal organs and six viscera. "The above "Huangdi Neijing: Lingshuo" shows that the skin, muscle, bone and internal organs of the human body are closely related. Various factors cause tissue damage, just like the hole in the wall, which is easy to make the external evil invade; or blood stasis and stagnation in the meat, then Yingqi does not follow, and the heat is depressed, like closing the door and leaving the evil, so that the blood stasis and heat become toxic. Blood stasis, then the heat is depressed, and the pus is brewed, appearing local red, swelling, hot, pain and the like.

[0004] There are many methods for treating skin soft tissue redness and swelling hot pain-like lesions caused by adult gout, skin soft tissue infection, fracture, sprain and the like, and the symptomatic treatment for gout is mostly oral non-steroidal anti-inflammatory analgesic drugs, the treatment for skin soft tissue infection is mostly anti-infection drugs, and the treatment for fracture and sprain is mostly cold compress and external application of ice nitrate powder and the like, but there are problems such as unsatisfactory clinical effect, inability to quickly and effectively relieve the pain of patients and the like, and different degrees of side effects such as gastrointestinal irritation, intestinal flora imbalance, fungal infection, liver and kidney function damage and the like.

[0005] Therefore, whether the treatment of skin soft tissue redness and swelling hot pain-like lesions can be better completed by combining the current situation of Chinese medicine science has become a problem to be solved. SUMMARY

[0006] In view of the deficiencies of the prior art, the present application provides a traditional Chinese medicine composition for treating skin redness, swelling, heat and pain-like lesions and a preparation method, which is composed of two components A and B, wherein component A contains radix isatidis, cortex lycii, radix puerariae, fructus gardeniae, radix sophorae flavescentis and giant knotweed; component B contains radices trichosanthis, cortex phellodendri, curcuma, radix et rhizoma rhei, radix angelicae dahuricae, magnolia officinalis, pericarpium citri reticulatae, rhizoma atractylodis and radix glycyrrhizae; component A is decocted to obtain juice, component B is ground into powder and mixed uniformly, when used, a certain amount of the A liquid is mixed with a certain amount of the B powder to form a paste, which is wrapped with single-layer gauze and applied externally to the painful area, and is removed after being fixed and retained for 1 hour, the composition has the effects of clearing heat and resolving toxins, cooling blood and drying dampness, removing blood stasis and activating collaterals, and relieving swelling and pain.

[0007] The inventors found in the process of clinical practice that patients with skin soft tissue redness, swelling, heat and pain-like lesions caused by adult gout, skin soft tissue infection, fracture and sprain have the pathogenesis of heat-toxin accumulation and blood stasis blocking collaterals, and there is no clinical guideline and treatment standard for this pathogenesis in the current traditional Chinese medicine treatment. Therefore, based on the above-mentioned pathogenesis of heat-toxin accumulation and blood stasis blocking collaterals, the inventors obtained the technical solution of the present application by modifying the existing classical prescription “Ruyi Jinhuang Powder”. Radix oppositifolii dioscoreae in the original prescription of “Ruyi Jinhuang Powder” is easy to cause skin discomfort and allergic reaction, so the inventors removed it and selected other drugs for combination, and finally obtained the traditional Chinese medicine composition having the effects of clearing heat and resolving toxins, cooling blood and drying dampness, removing blood stasis and activating collaterals, and relieving swelling and pain.

[0008] The specific technical solution of the present application is as follows:

[0009] A traditional Chinese medicine composition for treating skin redness, swelling, heat and pain-like lesions, which is composed of two components A and B, wherein component A contains radix isatidis, cortex lycii, radix puerariae, fructus gardeniae, radix sophorae flavescentis and giant knotweed; component B contains radices trichosanthis, cortex phellodendri, curcuma, radix et rhizoma rhei, radix angelicae dahuricae, magnolia officinalis, pericarpium citri reticulatae, rhizoma atractylodis and radix glycyrrhizae:

[0010] More specifically, the components are as follows in terms of weight parts:

[0011] Component A: radix isatidis 80-150 parts, cortex lycii 80-150 parts, radix puerariae 80-150 parts, fructus gardeniae 40-100 parts, radix sophorae flavescentis 15-50 parts and giant knotweed 40-100 parts.

[0012] Component B: radices trichosanthis 80-200 parts, cortex phellodendri 40-100 parts, curcuma 40-100 parts, radix et rhizoma rhei 40-100 parts, radix angelicae dahuricae 40-100 parts, magnolia officinalis 15-40 parts, pericarpium citri reticulatae 15-40 parts, rhizoma atractylodis 15-40 parts and radix glycyrrhizae 15-40 parts.

[0013] Preferably, the A component is 100-120 parts of Banlangen, 100-120 parts of Dikunpi, 100-120 parts of Gegen, 50-80 parts of Zhizi, 20-40 parts of Kushen, and 50-80 parts of Hujiang; the B component is 100-150 parts of Tianhuafen, 50-80 parts of Huangbai, 50-80 parts of Jianghuang, 50-80 parts of Dahuang, 50-80 parts of Baizhi, 20-30 parts of Huhuo, 20-30 parts of Chenpi, 20-30 parts of Cangzhu, and 20-30 parts of Gancao.

[0014] Further, the inventors have optimized the above components, and finally obtained the following optimal technical solution: the A component is 100 parts of Banlangen, 100 parts of Dikunpi, 100 parts of Gegen, 50 parts of Zhizi, 20 parts of Kushen, and 50 parts of Hujiang; the B component is 100 parts of Tianhuafen, 50 parts of Huangbai, 50 parts of Jianghuang, 50 parts of Dahuang, 50 parts of Baizhi, 20 parts of Huhuo, 20 parts of Chenpi, 20 parts of Cangzhu, and 20 parts of Gancao.

[0015] The more specific mechanism of the above traditional Chinese medicine composition is as follows:

[0016] Banlangen is bitter and cold in nature, and is attributed to heart and stomach meridians. It has the functions of clearing heat and resolving toxin, cooling blood, and benefiting the throat. It is used to treat warm toxin with skin rashes, erysipelas, and carbuncle and sore. Modern pharmacological studies have shown that Banlangen contains indigo, indigo blue, beta-sitosterol, palmitic acid, uridine, hypoxanthine, uracil, cyanide ketone, and daucus carota. It has inhibitory effect on various gram-positive bacteria, gram-negative bacteria, influenza virus, arbovirus, and mumps virus. It has obvious antipyretic effect and antioxidant effect. “Classification of Herbal Medicine”: “resolve various toxins and sores, disperse toxin and clear away heat, and be taken orally or applied topically”.

[0017] Dikunpi is sweet and cold in nature, and is attributed to lung, liver, and kidney meridians. It can cool blood and clear away heat. It can clear heat, cool blood, and stop bleeding. It contains cinnamic acid and a large amount of phenolic substances, betaine, beta-sitosterol, linoleic acid, and linolenic acid. Dikunpi decoction has immunoregulatory and antimicrobial effects. It has strong inhibitory effect on salmonella, paratyphi A, and shigella dysenteriae. It can inhibit the cytopathic effect of influenza virus strain A (Beijing) 68-1. Dikunpi extract can significantly improve the pain threshold and has obvious inhibitory effect on physical and chemical pain. “Pearl Capsule”: “resolve bone heat and muscle heat, treat diabetes, rheumatism, and stiffen bones and muscles, and cool blood”.

[0018] Pueraria root is sweet, pungent, and cooling. It enters the spleen and stomach meridians. It has the properties of relieving muscle tension, reducing fever, clearing rashes, promoting fluid production and quenching thirst, and promoting yang and stopping diarrhea. It can be used to treat measles that haven't cleared up, and in this recipe, pueraria root is used to expel pathogenic factors. Modern research shows that pueraria root contains flavonoids such as daidzin, daidzein, and puerarin, as well as daidzein-4,7-diglucoside, pueraria alcohol, kuervine vine, isoflavone glycosides, and starch. Pueraria root can directly dilate blood vessels, improve microcirculation, increase local microvascular flow, and inhibit platelet aggregation. It has a significant antipyretic effect. The Shennong Bencao Jing states: "It treats thirst... various arthritis, raises yin qi, and detoxifies." The Mingyi Bielu states: "It opens the pores, treats wounds, and relieves pain." The Yaoxing Lun states: "Boiled pueraria root can treat wounds."

[0019] Gardenia jasminoides (Gardenia jasminoides) is bitter and cold in nature, and enters the Heart, Lung, and Triple Burner meridians. It has the properties of purging heat and relieving restlessness, clearing heat and dampness, cooling the blood and detoxifying. It can treat fire-induced sores, redness, swelling, heat, and pain. Modern pharmacological research has shown that Gardenia jasminoides contains iso-gardenoside, didygenoside, gardenone glycoside, and the triterpenoid crocin. It has inhibitory effects on Staphylococcus aureus, Neisseria meningitidis, and Catarrhalis, and its aqueous extract has been shown to inhibit various dermatophytes in vitro. The "Shennong Bencao Jing" states: "Gardenia jasminoides treats internal pathogenic qi, stomach heat, facial redness, alcoholic sores, sniffing nose, white scabies, and red scabies."

[0020] Sophora flavescens is bitter and cold, and enters the heart, liver, stomach, large intestine, and bladder meridians. It has the properties of clearing heat and dampness, killing insects, and acting as a diuretic. Modern pharmacological research shows that Sophora flavescens contains alkaloids such as matrine, oxymatrine, sophorocarpine, and sophoramine, as well as flavonoids such as picrocarp C, picrocarp G, and matrine. Its decoction has inhibitory effects against Mycobacterium tuberculosis, Shigella dysenteriae, Staphylococcus aureus, and Escherichia coli, as well as against various dermatophytes. It also possesses anti-inflammatory, anti-allergic, and sedative properties. "Bencao Zhengyi" states: "Sophora flavescens is extremely bitter and cold, reducing fever, purging qi, and clearing dampness and heat. Its efficacy is similar to that of Scutellaria baicalensis, Coptis chinensis, and Gentiana scabra. However, Sophora flavescens is more bitter and has a more intense drying effect, so it is more potent in killing insects caused by dampness and heat than Scutellaria baicalensis and Coptis chinensis."

[0021] Polygonum cuspidatum (Polygonum cuspidatum) is slightly bitter and slightly cold. It enters the liver, gallbladder, and lung meridians, clearing away heat and detoxifying, dispersing blood stasis, and relieving pain. It is used to treat burns, carbuncles, sores, snake bites, and traumatic injuries. It contains polydatin, flavonoids, emodin, physcion methyl ether, resveratrol, and polysaccharides. Its decoction has inhibitory effects on various bacteria, including Staphylococcus aureus and Pseudomonas aeruginosa. It also has inhibitory effects on certain viruses. "Compendium of Materia Medica" states: "It can drain pus, treat sores, carbuncles, and boils, and relieve fainting in women due to blood loss. It can also treat blood stasis caused by wounds and dissipate wind-toxic qi."

[0022] Radix Trichosanthis, sweet, bitter, cold, returns to the lung and stomach meridians. It can clear heat and drain fire, generate fluid and relieve thirst, and resolve swelling and pus. It can treat feverish thirst, sores, swelling and pus. It contains starch, saponins, polysaccharides, amino acids, enzymes and trichosanthin. Trichosanthin has both immune stimulation and immune suppression effects; trichosanthin decoction has certain inhibitory effect on hemolytic streptococcus, pneumococcus and diphtheria bacillus. Shennong's Classic of Materia Medica: "It can nourish the middle energizer and restore the exhausted body." Rihua's Classic of Materia Medica: "It can resolve pus, swelling and toxin, promote tissue regeneration and resolve blood stasis. It can treat high fever, mastitis, back pain, hemorrhoids and abscesses."

[0023] Phellodendri Chinensis Cortex, bitter and cold, returns to the kidney, bladder and large intestine meridians. It has the functions of clearing heat and drying dampness, purging fire and removing heat, and detoxifying and treating sores. It can be used for sores, swelling and pus, and can be taken internally and externally. Phellodendri Chinensis Cortex contains berberine, phellodendrine, magnoflorine, jatrorrhizine, palmatine and other alkaloids, as well as phellodendri chinensis lactone, phellodendri chinensis ketone, phellodendri chinensis ketone acid and sterols. It has the effect of resisting pathogenic microorganisms, and can inhibit a variety of pathogenic bacteria such as dysentery bacillus, typhoid bacillus, tuberculosis bacillus, staphylococcus aureus and hemolytic streptococcus. It also has inhibitory effect on some skin fungi, leptospira and hepatitis B surface antigen.

[0024] Curcuma, pungent and bitter, warm, returns to the liver and spleen meridians. It has the functions of activating blood and qi, unblocking channels and relieving pain. Its pungent and warm properties can enter both blood and qi, and it can activate blood and qi to relieve pain. It can treat contusions and injuries, and swelling and pain. It contains volatile oil, the main components of which are turmerone, zingiberene, phellandrene, sabinene, eucalyptol, zedoary ketone, caryophyllene, camphor and camphor; pigment, the main component of which is curcumin; and annatto and bixin, as well as trace elements. Curcumin can inhibit platelet aggregation, reduce plasma viscosity and whole blood viscosity; curcumin has anti-inflammatory effect and can inhibit bacteria, while volatile oil has strong inhibitory effect on fungi. New Illustrated Classic of Materia Medica: "It can lower qi, break blood, remove wind and heat, and resolve abscesses and swelling. It is more effective than curcuma." Rihua's Classic of Materia Medica: "It can treat abscesses and swelling, contusions and blood stasis, and resolve swelling and toxin."

[0025] Rhubarb: bitter and cold, returns to the spleen, stomach, large intestine, liver and pericardium meridians. It can clear heat and drain fire, cool blood and detoxify, and remove blood stasis and unblock channels. It can treat toxic sores, burns and injuries, contusions and injuries, and swelling and pain. Modern pharmacological research shows that the main chemical components of rhubarb are anthraquinone derivatives, mainly including anthraquinone glycosides and bis-anthraquinone glycosides. It also contains tannins, organic acids and estrogen-like substances. Rhubarb has anti-infection effect, and can inhibit a variety of gram-positive and gram-negative bacteria, and also has inhibitory effect on influenza virus. In addition, it has the effects of hemostasis, liver protection, blood pressure reduction and cholesterol reduction. Classic of Materia Medica: "It can resolve pus, break blood stasis and resolve swelling." Compendium of Materia Medica: "(Rhubarb is used for) various fire sores."

[0026] Angelica dahurica: Pungent and warm, it enters the lung, stomach, and large intestine meridians. It dispels wind, relieves pain, and reduces swelling and discharges pus. Its pungent, dispersing, warming, and unblocking properties make it effective for dispersing swelling, relieving pain, and relieving redness, swelling, and heat in the skin. Modern pharmacological research shows that Angelica dahurica primarily contains volatile oils, as well as various coumarin compounds such as imperatorin and angelicae dahuricae, as well as angelicae toxins, zanthoxylum toxins, sterols, and stearic acid. A decoction of Angelica dahurica has a limited inhibitory effect on Escherichia coli, Shigella dysenteriae, Salmonella typhi, Pseudomonas aeruginosa, and Proteus. Its extract has a limited inhibitory effect on pathogenic fungi such as Microsporum audouinii. Compendium of Materia Medica states: "It can cure arsenic poisoning, snake bites, and wounds caused by swords, arrows, and wounds."

[0027] Magnolia officinalis: Bitter, pungent, and warm, it enters the spleen, stomach, lung, and large intestine meridians. It has the effects of drying dampness, eliminating phlegm, and relieving qi and fullness. Modern research shows that this herb contains volatile oils, primarily β-cineole and magnolol. It also contains small amounts of magnocurarine and magnolol tannins. A decoction of magnolia officinalis has inhibitory effects on pneumococci, diphtheria, hemolytic streptococci, Bacillus subtilis, Shigella dysenteriae, Staphylococcus aureus, Bacillus anthracis, and several dermatophytes. Magnolia officinalis and magnocurarine relax striated muscles. The Shennong's Herbal Classic states: "It treats qi and blood stagnation, muscle deadening, and the removal of three parasites."

[0028] Tangerine peel: Pungent, bitter, and warm, it enters the spleen and lung meridians. It regulates qi and strengthens the spleen, dissipates dampness, and resolves phlegm. Its pungent and aromatic properties are beneficial for regulating qi, promoting qi circulation, relieving numbness, and alleviating pain. Modern research indicates that tangerine peel contains nobiletin, hesperidin, neohesperidin, hesperetin, hydroxyfrine, and flavonoids. Tangerine peel contains 1.2%-3.2% volatile oil, including components such as α-thujene and limonene. Tangerine peel extract has been shown to scavenge oxygen free radicals and inhibit lipid peroxidation.

[0029] Atractylodes: Pungent, bitter, and warm, it enters the spleen, stomach, and liver meridians. It has a pungent, dispersing, bitter, and drying nature, making it effective in removing dampness and treating swelling and pain. Modern pharmacological research indicates that Atractylodes contains volatile oils, primarily atractylol (a crystalline mixture of β-cineole and atractylol). It also contains small amounts of atractylone, vitamin A-like substances, vitamin B, and inulin. "Shennong's Herbal Classic" states: "It treats wind-cold-damp arthritis, muscle spasms, and jaundice." "Ming Yi Bie Lu" states: "It eliminates phlegm and water, and expels swellings caused by wind and water accumulation within the skin."

[0030] Gancao: sweet, flat. Governs heart, lung, spleen, stomach meridians. Can relieve acute pain, clear heat and detoxify, regulate various drugs. The product tastes sweet and can relieve acute pain. It is also good at detoxification and has a wide range of applications. It has a slightly cold nature and can clear heat and detoxify. It is used to treat hot and toxic sores and ulcers and can be used alone to soak in decoction. It can also play a role in regulating the nature of drugs: by detoxifying, it can reduce the toxicity of certain drugs in the formula; by relieving acute pain, it can alleviate the irritation of certain drugs in the formula. Modern pharmacological studies have shown that the product contains triterpenes (triterpene saponins potassium, calcium salt of glycyrrhizin, which is the sweet component of licorice), flavonoids, alkaloids, polysaccharides and other components. It has anti-ulcer, analgesic effects. It has antibacterial, antiviral, anti-inflammatory, and anti-allergic effects. It has a detoxifying effect similar to glucuronolactone on certain poisons; it has an adrenocortical hormone-like effect. "Materia Medica": "It is a tonic for the middle and a detoxifier for the weak." "Materia Medica": "It is sweet and has the nature of balancing the middle and has the function of tonifying and detoxifying. It can be used to treat hot and toxic sores and ulcers."

[0031] The above-mentioned traditional Chinese medicine composition A component with Banlangen as the monarch drug, Banlangen, bitter and cold, governing heart and stomach meridians, has the functions of clearing heat and detoxifying, cooling blood and benefiting the throat. In this formula, it is used in large quantities to clear heat and detoxify and promote the dispersion of heat and toxic evils. Zhizi and Kushen are the minister drugs. Zhizi is bitter and cold, governing heart, lung and Sanjiao meridians. Its functions are to clear heat and relieve heat, clear heat and dampness, and cool blood and detoxify. It is used to treat hot and toxic sores and other heat syndromes. Kushen is bitter and cold, governing heart, liver, stomach, large intestine and bladder meridians. It can clear heat and dry dampness. The two drugs are used together to assist the monarch drug in clearing heat and detoxifying and cooling blood and reducing swelling. Gegen is sweet and pungent, cool, governing spleen and stomach meridians, and has the functions of relieving muscle and reducing fever, and can penetrate evil out. Dikongpi is sweet and cold, and can cool blood and remove heat. It is an assistant drug. Huzhang is slightly bitter and cold, and can clear heat and detoxify, dissipate stasis and relieve pain, and is a minister drug. The whole formula has the functions of clearing heat and detoxifying, reducing swelling and relieving pain.

[0032] In component B, Tianhuafen, Huangbai and Dahuang are the monarch drugs, which are bitter and cold, clear heat and purge fire, cool blood and detoxify, and reduce swelling and discharge pus. "Blood and swelling are relieved, pain is stopped", assisted by Jianghuang to activate blood, reduce swelling and relieve pain; Baizhi relieves superficies and relieves pain, reduces swelling and discharges pus, so that heat and toxic evils are discharged from the outside, combined with the monarch drug to internally and externally disperse heat and toxic evils. Assisted by Cangzhu, Houpu and Chenpi to dry dampness, invigorate the spleen, regulate qi and resolve phlegm, to stop the source of phlegm, and to assist qi and blood production, to help the monarch and minister drugs; Gancao clears heat and detoxifies, regulates various drugs, and alleviates the toxicity of drugs. The combination of various drugs has the functions of clearing heat and detoxifying, reducing swelling and relieving pain.

[0033] The combination of A and B drugs has stronger efficacy, and the functions of clearing heat and detoxifying, dissipating stasis and reducing swelling and relieving pain are more pronounced.

[0034] The inventors also provide a preparation method of the above-mentioned traditional Chinese medicine composition, the specific steps are as follows:

[0035] Group A: First, weigh out each flavor of Chinese medicine, add water to cover the medicine surface by 2-3 fingers, soak for 1-2 hours; first boil with a large fire, then simmer for 20-30 minutes with a small fire, filter out the medicine liquid for standby; add water to the medicine residue again, cover the medicine residue surface by 1-2 fingers, boil with a large fire, then simmer for 15-20 minutes with a small fire; filter out the medicine liquid and combine with the previous medicine liquid, simmer for 10-15 minutes with a small fire for concentration; filter out the concentrated medicine liquid and air dry for standby.

[0036] Group B: First, weigh out each flavor of Chinese medicine, grind into fine powder, and store in a porcelain bottle for standby.

[0037] Preferably, the Chinese medicine components in group B are ground into 200-mesh fine powder and stored in a porcelain bottle.

[0038] When the above Chinese medicine composition is applied, according to the size of the lesion site, mix and stir A medicine liquid and B medicine powder in a ratio of 5ml:3g, adjust into a paste, make the medicine paste dry and wet moderately, have a certain plasticity, do not scatter after grabbing, and do not flow when standing to obtain a medicine paste.

[0039] Generally, the amount of A medicine liquid is controlled at 50-100ml, and the amount of B medicine powder is controlled at 30-60g.

[0040] The prepared medicine paste is wrapped with single-layer gauze, spread on the affected area for external use, fixed with fresh-keeping film, bandage, adhesive tape, etc., removed after 1 hour, and used twice a day. 5-7 days is a course of treatment, the symptoms of mild cases disappear after 1 course of treatment, and the symptoms of severe cases disappear after 2-3 courses of treatment.

[0041] The main reason for the combination of A component and B component drugs is:

[0042] Through long-term clinical practice, it is found that single use of A component medicine liquid or use of warm water to adjust B component medicine powder into a paste for external use on the affected area has the effects of reducing swelling, reducing fever, and relieving pain, but the combination of A component and B component drugs, prepared for external use by the method in the invention, can achieve better efficacy, which is obviously improved compared with single use of A liquid or B powder.

[0043] The main reason for grinding the Chinese medicine composition in group B into fine powder, preferably 200-mesh fine powder, and storing in a porcelain bottle is that grinding into fine powder can better release the drug components during the application process and effectively penetrate into the skin to take effect. The multiple drugs in group B contain volatile oil components, and storage in a porcelain bottle can maximize the prevention of the volatilization of effective volatile oil components, thereby reducing the drug efficacy and wasting the drug.

[0044] The medicine obtained by using the above-mentioned prescription and preparation method has very significant curative effect after being applied in clinic, 5-7 days is a treatment course, the symptoms of the patients with light illness disappear after one treatment course, the symptoms of the patients with severe illness disappear after 2-3 treatment courses, and there is no side effect, so the medicine has very obvious advantages compared with various existing treatment medicines and fills the blank in the field.

[0045] In conclusion, the present application provides a traditional Chinese medicine composition and preparation method for treating skin soft tissue redness, heat and pain, based on the pathogenesis of heat and blood stasis caused by gout, skin soft tissue infection, fracture, sprain and the like, the composition has the effects of clearing heat and resolving toxins, cooling blood and drying dampness, removing blood stasis and activating collaterals, reducing swelling and relieving pain, and the combination of various drugs has significant curative effect on skin soft tissue redness, heat and pain. BRIEF DESCRIPTION OF DRAWINGS

[0046] Figure 1 The figure shows the affected area of case 1 before treatment;

[0047] Figure 2 The figure shows the affected area of case 1 after 5 doses are applied;

[0048] Figure 3 The figure shows the affected area of case 2 before treatment;

[0049] Figure 4 The figure shows the affected area of case 2 after 5+3 doses are applied.

[0050] DETAILED DESCRIPTION

[0051] The present application is not limited by the following examples, the following examples and descriptions described in the specification are only to illustrate the principles of the present application, and various changes and improvements can be made without departing from the spirit and scope of the present application, and these changes and improvements all fall within the scope of the claimed present application.

[0052] Example 1

[0053] A traditional Chinese medicine composition for treating skin soft tissue redness, heat and pain caused by gout, skin soft tissue infection, fracture, sprain and the like, is composed of:

[0054] A component: 100g of isatis root, 100g of cortex lycii, 100g of pueraria, 50g of gardenia, 20g of sophora, and 50g of giant knotweed.

[0055] B component: 100g of trichosanthes, 50g of cortex phellodendri, 50g of curcuma, 50g of rhubarb, 50g of baizhi, 20g of magnolia officinalis, 20g of dried tangerine or orange peel, 20g of atractylodes, and 20g of licorice.

[0056] The preparation method is as follows:

[0057] (1) Component A: First weigh out each Chinese herbal medicine and mix it, add water until it covers the surface of the medicine by 2-3 fingers, and soak for 1-2 hours; first boil it over high heat, then simmer it over low heat for 20-30 minutes, filter out the liquid medicine and set aside; add water to the medicinal residue again until it covers the surface of the medicinal residue by 1-2 fingers, boil it over high heat, then simmer it over low heat for 15-20 minutes; after filtering out the liquid medicine, combine it with the previous liquid medicine, simmer it over low heat for 10-15 minutes again to concentrate it; filter out the liquid medicine and let it cool for later use.

[0058] (2) Component B: Weigh out the various Chinese medicinal herbs, mix them, grind them into a very fine powder (about 200 mesh), and store them in a porcelain bottle for later use.

[0059] (3) When using, according to the size of the lesion, take 50 ml of the A liquid prepared in step (1) and 30 g of the B powder prepared in step (2), mix and stir, and adjust to a paste. The paste should be moderate in dryness and wetness, have a certain plasticity, do not fall apart when grasped, and do not flow when left to stand, thus obtaining the target drug.

[0060] When using the above-mentioned Chinese medicine composition, the target drug prepared above is wrapped with a single layer of gauze, spread on the affected area for external application, fixed with plastic wrap, bandage, adhesive tape, etc., and left on for 1 hour before removal. A course of treatment is 5-7 days.

[0061] Example 2

[0062] A traditional Chinese medicine composition for treating red, swollen, hot and painful skin and soft tissue lesions caused by gout, skin and soft tissue infections, fractures, sprains, etc. in adults, is prepared from the following drugs:

[0063] Component A: 120g of Isatis root, 120g of Rehmannia root, 120g of Pueraria root, 80g of Gardenia jasminoides, 30g of Sophora flavescens, and 80g of Polygonum cuspidatum.

[0064] Component B: Radix Trichosanthis 140g, Cortex Phellodendri 80g, Rhizoma Curcumae 80g, Rhubarb 80g, Angelica dahurica 80g, Magnolia officinalis 30g, Citrus reticulatae 30g, Atractylodes lancea 30g, Licorice 30g.

[0065] The preparation method is as follows:

[0066] (1) Component A: First weigh out each Chinese herbal medicine and mix it, add water until it covers the surface of the medicine by 2-3 fingers, and soak for 1-2 hours; first boil it over high heat, then simmer it over low heat for 20-30 minutes, filter out the liquid medicine and set aside; add water to the medicinal residue again until it covers the surface of the medicinal residue by 1-2 fingers, boil it over high heat, then simmer it over low heat for 15-20 minutes; after filtering out the liquid medicine, combine it with the previous liquid medicine, simmer it over low heat for 10-15 minutes again to concentrate it; filter out the liquid medicine and let it cool for later use.

[0067] (2) Component B: First weigh out the various Chinese medicinal herbs, mix them, grind them into a very fine powder (about 200 mesh), and store them in a porcelain bottle for later use.

[0068] (3) using, the A medicine liquid prepared in step (1) 100ml and B medicine powder prepared in step (2) 60g are mixed and stirred to make paste, the paste is moderately dry and wet, has certain plasticity, does not scatter after holding, does not flow when standing, and the target medicine is obtained.

[0069] The application method is the same as that of example 1.

[0070] Example 3

[0071] A traditional Chinese medicine composition for treating skin and soft tissue swelling, heat and pain caused by gout, skin and soft tissue infection, fracture, sprain and the like is prepared from the following drugs:

[0072] A component: Banlangen 110g, Dikongpi 110g, Gegen 110g, Zhizi 60g, Kushen 20g, Huzhang 60g.

[0073] B component: Tianhuafen 120g, Huangbai 60g, Rhizoma Curcumae 60g, Dahuang 60g, Baizhi 60g, Hupu 20g, Chenpi 20g, Cangzhu 20g, Gancao 25g.

[0074] The preparation method is as follows:

[0075] (1) A component: first, weigh the mixed traditional Chinese medicines, add water to cover the medicine surface by 2-3 fingers, soak for 1-2 hours; first boil with large fire, then simmer with small fire for 20-30 minutes, filter the medicine liquid for standby; add water to the medicine residue again, cover the medicine residue surface by 1-2 fingers, boil with large fire, then simmer with small fire for 15-20 minutes; filter the medicine liquid and combine with the previous medicine liquid, simmer with small fire for 10-15 minutes for concentration; filter the medicine liquid and air dry for standby.

[0076] (2) B component: first, weigh the mixed traditional Chinese medicines, grind into fine powder (about 200 meshes), and store in a porcelain bottle for standby.

[0077] (3) using, the A medicine liquid prepared in step (1) 100ml and B medicine powder prepared in step (2) 60g are mixed and stirred to make paste, the paste is moderately dry and wet, has certain plasticity, does not scatter after holding, does not flow when standing, and the target medicine is obtained.

[0078] The application method is the same as that of example 1.

[0079] Experimental example

[0080] 1. Clinical data

[0081] 1.1 Case source

[0082] A total of 80 patients were included in this study, all from the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 2022 to December 2023. All patients were diagnosed with gout, skin and soft tissue infection, fracture, sprain, and other causes of skin and soft tissue swelling, redness, heat, and pain.

[0083] 1.2 Diagnostic criteria

[0084] 1.2.1 Gout patients: acute joint pain, redness, swelling, fever. Physical examination found gouty tophi. Blood uric acid levels were significantly elevated.

[0085] 1.2.2 Skin and soft tissue infection: skin injury, infection after damage, local redness, heat, pain, fever, and other infection symptoms such as white blood cell count increase. Suppurative skin and soft tissue infection, common are furuncle, carbuncle, acute cellulitis, erysipelas, etc., the specific characteristics are as follows:

[0086] Furuncle is an acute bacterial suppurative inflammation of a single hair follicle and its surrounding tissue, often caused by Staphylococcus aureus, commonly found on the head, face, neck, and buttocks. In the early stages of the disease, it presents as a small, red, swollen, hot, and painful nodule that gradually enlarges, with a yellow-white pus head appearing in the center after several days. Furuncles are usually solitary, but if they occur repeatedly and in large numbers, they are considered to be furunculosis.

[0087] Carbuncle is an acute suppurative inflammation of multiple adjacent hair follicles and their surrounding tissue, or a fusion of multiple adjacent furuncles. It often occurs on the thick skin of the neck, back, and thighs, and can reach a size of 10 cm or more. Initially, it presents as a diffuse, infiltrative, purplish-red rash with a shiny surface and obvious tenderness. Multiple pus heads then appear, with many pus plugs and bloody secretions being discharged, accompanied by tissue necrosis and ulceration, and visible sinus tracts and enlarged local lymph nodes. Clinically, patients experience pulsatile pain, fever, chills, headache, loss of appetite, and other systemic symptoms. In severe cases, it can lead to toxicemia, sepsis, and even death. The disease heals slowly and is accompanied by scarring.

[0088] Acute cellulitis is characterized by local redness, swelling, heat, and pain, which rapidly spreads to the surrounding area. The red and swollen skin has no clear boundary with the surrounding normal tissue, with the central part being darker in color and the surrounding part being lighter. In cases of superficial infection and loose tissue, the swelling is obvious and diffuse, with mild pain. In cases of deep infection or dense tissue, the swelling is not obvious, but the pain is severe. Patients often have varying degrees of systemic symptoms such as chills, fever, headache, fatigue, and increased white blood cell count. Generally, deep cellulitis, anaerobic bacteria, and gas-producing bacteria cause twisting cellulitis, which has more obvious systemic symptoms such as chills, high fever, convulsions, and delirium. Diagnosis can be made based on typical local and systemic manifestations and signs. Elevated white blood cell count, pus cytology, and culture can aid in diagnosis.

[0089] Erysipelas is an infection involving the superficial lymphatics of the dermis, the main pathogenic bacteria is group A beta-hemolytic streptococcus. The predisposing factors are surgical wounds or fissures in the nostrils, external auditory canal, under the earlobe, anus, penis and between the toes. Any inflammation of the skin, especially with fissures or ulcers, provides a route of entry for the pathogenic bacteria. The pathogenic bacteria can be latent in the lymphatics, causing recurrence. Incubation period 2-5 days. The prodromal symptoms are sudden fever, chills, malaise and nausea. Redness appears after a few hours to a day, and progresses to enlarge, with clear boundaries. The skin temperature is high, tense, and there are induration and non-depressed edema, the affected area has tenderness, burning pain, and often the nearby lymph nodes are swollen, with or without lymphadenitis. Pus, blisters or small areas of hemorrhagic necrosis can also occur. It is often seen in the lower leg, facial part. Swab gram staining and bacterial culture of the wound and damaged part; blood anti-streptolysin O and white blood cells; dandruff mycology examination can assist in diagnosis.

[0090] 1.2.3 Local redness, swelling, heat and pain caused by fracture or sprain. There is a history of recent fracture or sprain, and redness, swelling, heat and pain around the lesion.

[0091] 1.2.4 Diagnosis criteria of TCM syndrome

[0092] Toxic heat accumulation syndrome: local tissue redness, swelling, heat and pain, tenderness, can be accompanied by fever, dry mouth, irritability, red face, red tongue, yellow fur, slippery pulse or stringy pulse.

[0093] Blood stasis blocking the collaterals syndrome: local redness, swelling, pain in a fixed place, tenderness is lighter, generally no fever or mild fever, dark complexion, dark tongue, ecchymosis, pulse is astringent.

[0094] 1.3 Implementation criteria

[0095] 1.3.1 Inclusion criteria

[0096] ① Complete and reliable clinical data; ② Local redness, swelling, heat and pain-like lesions caused by the above reasons; ③ Good compliance, informed consent and objective and true filling of the questionnaire.

[0097] 1.3.2 Exclusion criteria

[0098] ① Large area of skin ulcer or large wound, large amount of bleeding; ③ Pregnant or lactating women; ④ Have contraindications or allergies to drugs; ⑤ Combined with severe dysfunction of liver, kidney and other organs.

[0099] 1.3.3 Drop-out and exclusion criteria:

[0100] ① The patient lost follow-up. ② The patient withdrew himself. ③ The patient did not comply with the requirements of the research program. ④ The patient had adverse reactions during the study.

[0101] 2. Research methods

[0102] 2.1 Study design

[0103] The 80 patients included were randomly divided into an observation group and a control group using a random number table, with 40 patients in each group. The observation group was treated with the pharmaceutical composition of Example 1, and the control group was treated with general treatment. Both the observation group and the control group were treated for 7 days, and the VAS pain scores and swelling degree changes were observed before and after treatment. After the treatment period, all data were statistically analyzed using statistical software SPSS 20.0 to compare the differences between the observation group and the control group before and after treatment.

[0104] 2.2 Treatment method

[0105] Control group: routine treatment for various diseases, including painkillers, anti-infective drugs, etc. Ice packs or ice nitre can be used for external application.

[0106] Observation group:

[0107] The pharmaceutical liquid and powder were obtained using the process and dosage of Example 1, and were mixed and stirred before being applied to the affected area twice a day, for 1 hour each time.

[0108] 2.3 Treatment course

[0109] Observation group and control group: 7 days of treatment.

[0110] 2.4 Observation indicators and safety evaluation criteria

[0111] 2.4.1 Observation indicators

[0112] (1) Observation and comparison of pain symptom scores before and after treatment: evaluated according to the VAS pain score grading standard.

[0113] Pain degree: ① No pain: 0 points. ② Mild pain, tolerable: 1-3 points. ③ Patients have pain and affect sleep, but can still tolerate: 4-6 points. ④ Patients have strong pain, unbearable pain, affecting appetite and sleep: 7-10 points.

[0114] (2) Swelling degree: according to the observation of the physician, the swelling degree is divided into 4 grades, with 0-3 points respectively: 0 grade: no swelling; 1 grade: slight swelling; 2 grade: obvious swelling; 3 grade: very severe swelling.

[0115] The above symptoms and indicators were evaluated before and after treatment.

[0116] 2.4.2 Safety evaluation criteria:

[0117] Level 1: safe, no adverse reactions.

[0118] Level 2: relatively safe, with mild adverse reactions that do not require treatment and can continue to use the drug.

[0119] 3. Grade 3: safety concerns, but adverse reactions are not serious, and can continue to use after treatment.

[0120] 4. Grade 4: serious safety concerns, and cannot continue to use after treatment.

[0121] 2.5 Statistical methods

[0122] All data were analyzed by statistical software SPSS20.0. All statistical tests were applied by two-sided test, with P<0.05 as the difference was statistically significant, and P<0.01 as the difference was significant. During the study, all data were expressed by mean ± standard deviation . The comparison of pre-treatment and post-treatment between groups used independent sample t test, and the comparison of pre-treatment and post-treatment within groups used paired sample t test, non-graded classification data used X 2 test, and ranked data used rank sum test.

[0123] 3. Research results

[0124] 3.1 General information

[0125] All patients came from the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine Department of Orthopedics from January 2022 to December 2022 outpatient or inpatient, a total of 80 cases, 40 cases in the observation group and the control group, two groups of patients during treatment were not lost. Among them, the observation group (17 females and 15 males) was the youngest 18 years old, the oldest 60 years old, and the average was 49.78±10.22 years old; the control group (16 females and 16 males) was the youngest 19 years old, the oldest 58 years old, and the average was 49.12±9.88 years old. Statistical analysis and comparison showed that there was no statistical difference between the two groups in age (see Table 1).

[0126] Table 1 Comparison of age distribution between the two groups (years)

[0127]

[0128] The comparison of age between the two groups showed that there was no statistically significant difference (P>0.05), indicating that the two groups were comparable in age.

[0129] 3.2 Comparison of pain symptom scores before and after treatment in the two groups

[0130] Table 2 Comparison of pain symptom scores before and after treatment in the two groups

[0131]

[0132] Note: compared with before treatment △P<0.05, △△P<0.01, compared with control group after treatment▲P<0.05, ▲▲P<0.01.

[0133] Statistical analysis showed that the symptom scores of the two groups before treatment had no statistical significance (P>0.05) and were comparable. The pain symptoms of the observation group were significantly improved after treatment, with significant difference (P<0.01); the control group could improve the degree of pain (P<0.01). After treatment, the observation group was significantly better than the control group, and the statistical results of the two groups had significant difference (P<0.01) (see Table 2).

[0134] 3.3 Comparison of swelling degree scores of the two groups before and after treatment

[0135] Table 3 Comparison of swelling degree scores of the two groups before and after treatment

[0136]

[0137] Note: compared with before treatment △P<0.05, △△P<0.01, compared with control group after treatment▲P<0.05, ▲▲P<0.01.

[0138] Statistical analysis showed that the DLQI scores of the two groups before treatment had no statistical significance (P>0.05) and were comparable. The observation group and the control group were improved after treatment than before treatment (P<0.05), and the observation group was significantly improved, with significant difference (P<0.01). After treatment, the observation group was significantly better than the control group, with significant difference (P<0.01) (see Table 3).

[0139] 3.4 Comparison of total effective rate of the two groups before and after treatment

[0140] Table 4 Comparison of total effective rate of the two groups before and after treatment

[0141]

[0142] Note: compared with the control group △△P<0.01.

[0143] Statistical analysis showed that the total effective rate of the observation group was 97.5%, and the total effective rate of the control group was 85%. The observation group was significantly better than the control group, with significant difference (P<0.01) (see Table 4).

[0144] 3.5 Safety evaluation

[0145] No drug-related discomfort symptoms and adverse reactions occurred in the two groups during the study, so the safety of the two groups was good, and the safety evaluation was grade 1.

[0146] In summary, the present application combines the theory of traditional Chinese medicine, based on the pathogenesis of heat and toxin accumulation, blood stasis and obstruction of collaterals in patients with skin and soft tissue swelling, heat and pain caused by gout, skin and soft tissue infection, fracture, sprain, etc. A traditional Chinese medicine composition for treating skin and soft tissue swelling, heat and pain caused by gout, skin and soft tissue infection, fracture, sprain, etc. and a preparation method are provided. The composition has the effects of clearing heat and resolving toxins, cooling blood and drying dampness, removing blood stasis and activating collaterals, reducing swelling and relieving pain. The combination of various drugs has significant effects on the treatment of skin and soft tissue swelling, heat and pain caused by gout, skin and soft tissue infection, fracture, sprain, etc.

[0147] Specific cases

[0148] Case 1

[0149] On March 27, 2022, Liang, a male born in 1978, had redness, swelling and pain in his left big toe for 3 days. He was previously healthy, and 3 days ago he had no obvious inducement of redness, swelling and pain in his left big toe. At first, the degree was lighter, and in the past 2 days, the symptoms gradually worsened. Physical examination showed that the left big toe joint was red and swollen, with bright red color, obvious tenderness, and walking was claudication (as shown in Figure 1 ). The uric acid was 768 umol / L. He was irritable, had normal appetite, average sleep, yellowish urine, and dry stool. His tongue was red, with yellow fur, and his pulse was rapid and frequent. Diagnosis: gout.

[0150] Treatment: The drug composition prepared in Example 1 was used. When using, 50 ml of Step A liquid and 30 g of Step B powder were mixed and stirred to form a paste, which was wrapped with single-layer gauze and applied to the affected area, then fixed with bandage and adhesive tape. After 1 hour, it was removed, and used 2 times a day in the morning and evening. He should have a light diet, avoid spicy, seafood and alcohol, reduce activity on the affected side, and follow up if necessary.

[0151] On April 2, 2022, the patient returned for a follow-up visit for toe pain. After taking the medicine, the symptoms of redness, swelling and pain were basically gone (as shown in Figure 2 ), and he continued the treatment, took 1 dose as before (on March 27, 2022), followed the diet, and followed the previous doctor's advice.

[0152] Case 2

[0153] On May 22, 2022, Ding, a female born in 1970, had redness, swelling and pain in her left foot for 1 day. She had a history of hypertension, coronary heart disease and diabetes, and took oral medication regularly. Yesterday, she had no obvious inducement of redness, swelling and pain in her left foot, and she was afraid to move. The pain gradually worsened, and she couldn't sleep at night. Physical examination showed that the left foot was swollen, the skin was red, the skin temperature was high, the dorsum of the foot was red and swollen, and the left foot was limited in active and passive flexion and extension due to pain. The toe end had normal blood supply and sensation (as shown in Figure 3 ). Diagnosis: left foot erysipelas.

[0154] Treatment: the pharmaceutical composition prepared in Example 2 is used, 100 ml of the liquid in step A is mixed with 60 g of the powder in step B to form a paste, which is wrapped with single-layer gauze and applied to the affected area, and then fixed with a bandage and adhesive tape, and removed after 1 hour, twice a day in the morning and evening. Light diet, immobilization on the affected side, and follow-up for discomfort.

[0155] 2022.5.27 Left foot redness, heat and pain were reexamined. After 5 days of treatment, the patient's swelling and pain were significantly reduced, and the treatment was continued, 3 doses of the same as before (2022.5.22), and the affected side was moderately active.

[0156] 2022.05.30 Reexamination, the patient's left foot had no obvious redness, heat and pain, and was active, with normal skin color and temperature, and no obvious tenderness (as shown in Figure 4 ).

[0157] Case 3

[0158] 2022.6.15 Li, female, born in 1984, left thigh redness for 2 days, previously healthy. 2 days ago, red papules appeared on the left thigh without obvious cause, gradually developed pain, and the range increased, with a diameter of about 1.5 cm, sharp head, no pus point, and obvious tenderness. Tongue red with thin yellow fur, and pulse string. Diagnosis: Boil.

[0159] Treatment: the pharmaceutical composition prepared in Example 3 is used, 50 ml of the liquid in step A is mixed with 30 g of the powder in step B to form a paste, which is wrapped with single-layer gauze and applied to the affected area, and then fixed with plastic wrap and adhesive tape, and removed after 1 hour, twice a day in the morning and evening. Light diet, and follow-up for discomfort.

[0160] 2022.6.20 Reexamination. The redness and swelling of the lesion subsided. Light diet, rest, no need for continued medication, and follow-up for discomfort.

[0161] As can be seen from the above clinical test results, the traditional Chinese medicine composition obtained by the application is mainly used for treating skin redness, heat and pain, with the functions of clearing heat and detoxifying, cooling blood and drying dampness, removing blood stasis and activating collaterals, and relieving swelling and pain. The combination of various drugs has significant effects on reducing inflammation in the affected area and relieving local congestion, edema and pain.

Claims

1. A Chinese medicine composition for treating skin redness, swelling, heat and pain-like lesions, characterized in that: The composition consists of two components, A and B, wherein component A contains Radix Isatidis, Cortex Lycii, Radix Puerariae, Fructus Gardeniae, Sophorae Flavescentis and Polygonum Cuspidati; component B contains Radix Trichosanthis, Cortex Phellodendri, Curcuma Longa, Rhubarb, Angelica Dahuricae, Magnolia Officinalis, Pericarpium Citri Reticulatae, Atractylodes Rhizome and Licorice. The components are calculated in parts by weight as follows: Component A: 80-150 parts of Radix Isatidis, 80-150 parts of Cortex Lycii, 80-150 parts of Radix Puerariae, 40-100 parts of Gardenia, 15-50 parts of Sophora flavescens, and 40-100 parts of Polygonum cuspidatum; Component B: 80-200 parts of Radix Trichosanthis, 40-100 parts of Cortex Phellodendri, 40-100 parts of Curcuma Longa, 40-100 parts of Radix Rhei, 40-100 parts of Radix Angelicae Dahuricae, 15-40 parts of Cortex Magnoliae, 15-40 parts of Pericarpium Citri Reticulatae, 15-40 parts of Atractylodes Rhizome, and 15-40 parts of Radix Glycyrrhizae.

2. The Chinese medicine composition for treating skin redness, swelling, heat and pain according to claim 1, characterized in that: The component A comprises, by weight, 100-120 parts of isatis root, 100-120 parts of lycium bark, 100-120 parts of kudzu root, 50-80 parts of gardenia, 20-40 parts of sophora flavescens, and 50-80 parts of polygonum cuspidatum; the component B comprises, by weight, 100-150 parts of trichosanthes root, 50-80 parts of phellodendron amurense, 50-80 parts of turmeric, 50-80 parts of rhubarb, 50-80 parts of angelica dahurica, 20-30 parts of magnolia bark, 20-30 parts of tangerine peel, 20-30 parts of atractylodes, and 20-30 parts of liquorice.

3. The Chinese medicine composition for treating skin redness, swelling, heat and pain according to claim 1 or 2, characterized in that: Component A is calculated by weight as follows: 100 parts of isatis root, 100 parts of lycium bark, 100 parts of kudzu root, 50 parts of gardenia, 20 parts of sophora flavescens, and 50 parts of polygonum cuspidatum; component B is calculated by weight as follows: 100 parts of trichosanthes root, 50 parts of phellodendron amurense, 50 parts of turmeric, 50 parts of rhubarb, 50 parts of angelica dahurica, 20 parts of magnolia bark, 20 parts of tangerine peel, 20 parts of atractylodes, and 20 parts of licorice.

4. The method for preparing the Chinese medicine composition for treating skin redness, swelling, heat and pain-like lesions according to claim 1, characterized in that: The specific steps are as follows: Group A: First, weigh out each Chinese herbal medicine, mix it, add water until it covers the surface of the medicine by 2-3 fingers, and soak it for 1-2 hours; first boil it over high heat, then simmer it over low heat for 20-30 minutes, filter the liquid and set aside; add water to the medicinal residue again until it covers the surface of the medicinal residue by 1-2 fingers, boil it over high heat, then simmer it over low heat for 15-20 minutes; after filtering out the liquid, combine it with the previous liquid and simmer it over low heat for another 10-15 minutes to concentrate it; filter out the concentrated liquid and let it cool for later use; Group B: First, weigh out all the Chinese herbs, mix them, grind them into a very fine powder, and store them in a porcelain bottle for later use; The target Chinese medicine composition is obtained by mixing the A liquid and the B powder in a ratio of 5 ml:3 g to form a paste. The paste has a moderate wetness and a certain plasticity. The paste does not fall apart when grasped and does not flow when left standing.

5. The method for preparing the Chinese medicine composition for treating skin redness, swelling, heat and pain according to claim 4, characterized in that: The Chinese medicinal components in group B were ground into 200-mesh fine powder.

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