Compound lophatherum gracile formula granules and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine preparations, and discloses compound lophatherum gracile formula granules and a preparation method of the compound lophatherum gracile formula granules. 5-7 parts of a wormwood extracting solution; 10 to 15 parts of herba houttuyniae extract; 8-11 parts of a chrysanthemum extract; 5-9 parts of a fructus cnidii extract; 2-5 parts of a fresh ginger extract; 5-8 parts of red ginseng powder; 14 to 15 parts of phaseolus calcaratus powder; by adding the wormwood extracting solution, the fresh ginger extracting solution and the fructus cnidii extract and adjusting the dosage of the ginger extracting solution and the fructus cnidii extract in the formula, the invention provides a formula for diminishing inflammation and relieving itching, and the wormwood extracting solution and the fresh ginger extracting solution are combined and matched, so that the effect of diminishing inflammation and relieving itching is achieved. The effects of promoting digestion and warming the body can be kept, so that the requirements of consumers with cold physique and poor gastrointestinal functions can be met.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a compound loblolly leaf formula granule and a preparation method thereof. Background Art

[0002] In the field of traditional Chinese medicine, Lophatherum gracile Brongn. is widely used as a medicinal material to treat a variety of diseases such as hypertension, diabetes and nephritis with its heat-clearing, diuretic, anti-inflammatory and detoxifying properties. However, the cold nature of Lophatherum gracile Brongn. limits its application in certain groups of people, especially consumers with cold constitution or poor gastrointestinal function. In addition, the traditional method of use, i.e. oral administration after decoction, also brings a series of practical inconveniences in modern social life. Summary of the invention

[0003] 1. Technical issues to be resolved In view of the shortcomings of the prior art, the present invention provides a compound loquat leaf formula granule and a preparation method thereof, which has the advantages of being easy to carry and adaptable to consumers with cold constitution or poor gastrointestinal function, thereby solving the problem that it is inconvenient to carry and consumers with cold constitution or poor gastrointestinal function cannot adapt to it.

[0004] (II) Technical solution To achieve the above object, the present invention provides the following technical scheme: a compound bamboo leaf formula granule, the bamboo leaf formula granule ingredients include: bamboo leaf extract, wormwood extract, houttuynia extract, chrysanthemum extract, cnidium monnieri extract, fresh ginger extract, red ginseng powder, adzuki bean powder and coix seed powder; The granular raw materials include, by weight: 20-25 parts of loblolly leaf extract; 5-7 parts of wormwood extract; 10-15 parts of houttuynia cordata extract; 8-11 parts of chrysanthemum extract; 5-9 parts of cnidium monnieri extract; 2-5 parts of fresh ginger extract; 5-8 parts of red ginseng powder; 14-15 parts of adzuki bean powder; and 6-9 parts of coix seed powder.

[0005] Preferably, the preparation process of the Bambusa scabra extract is: S1.1, Pretreatment: Wash the fresh bamboo leaves, put them into an oven and dry them at 80℃ for 30min. After drying, the water content of the bamboo leaves is 5%; S1.2, crushing and mixing: crush the dried bamboo leaves into powder using a traditional Chinese medicine crusher, and mix them evenly with distilled water at a mass ratio of 1:20 and soak for 12 hours; S1.3, extraction: add the powder of the light bamboo leaves into 50% ethanol, keep it at 40℃ for 40min, use a centrifuge, centrifuge at 2000 rpm for 30min, and let it stand for 2h after centrifugation; S1.4, filtration and concentration: the supernatant obtained after standing is added into a rotary evaporator for distillation and concentration; S1.5. Drying: The concentrated extract was placed in a vacuum dryer for 30 minutes to obtain a concentrated extract of the Bambusa chinensis leaves.

[0006] Preferably, the preparation process of the wormwood extract is: S2.1. Selection and cleaning: Select fresh, pest-free mugwort and clean it thoroughly; S2.2, cutting: cut the cleaned mugwort into pieces of 0.5cm-1.0cm; S2.3, soaking: Soak the cut mugwort in clean water for 6 hours; S2.4, extraction: put the soaked wormwood into the extraction machine, add 50% distilled water, set the heating temperature to 40°C, and set the extraction time to 30 minutes; S2.5, Filtration: After the extraction is completed, the extract is filtered using a microporous membrane filter to remove solid residues; S2.6. Concentration: The filtered extract is concentrated to 1% of the original volume using a vacuum concentration method to reduce the amount of solvent to obtain an wormwood extract.

[0007] Preferably, the preparation process of the Cnidium monnieri extract is: S3.1. Raw material preparation: Select mid-mature, pest-free Cnidium monnieri and clean them; S3.2, crushing: crush the cleaned Cnidium monnieri with a crusher, and the particle size of the crushed particles is 1mm-1.2mm; S3.3, extraction: mix the crushed Cnidium monnieri particles with 50% ethanol in a ratio of 1:1, put into an extractor, set the heating temperature to 55°C, set the extraction time to 20 minutes, and use a glass rod to stir continuously during the process; S3.4, Filtration: After the extraction is completed, the Cnidium monnieri extract is filtered using a microporous membrane filter to remove solid residues; S3.5, concentration: the filtered Cnidium monnieri extract is concentrated to 1% of the original volume by vacuum concentration to reduce the amount of solvent, thereby obtaining a Cnidium monnieri extract concentrate; S3.6. Drying: The Cnidium monnieri extract concentrate is placed in a vacuum dryer for 2 hours to obtain the Cnidium monnieri extract.

[0008] Preferably, a method for preparing a compound loblolly leaf formula granule is provided, wherein the method is used for the loblolly leaf formula granule, and the method comprises the following steps: Step 1, extraction: extract light bamboo leaves, wormwood, houttuynia cordata, chrysanthemum, cnidium monnieri and fresh ginger respectively; Step 2, grinding: Grind red ginseng, adzuki beans and coix seeds into powder with a particle size of 50 microns to 80 microns using a grinder; Step 3: Weighing: weigh the extracted and ground raw materials according to the formula ratio; Step 4, mixing powder: mix red ginseng powder, adzuki bean powder and coix seed rice powder evenly according to the proportion; Step 5, mixing the extracts: uniformly mixing the extract of Bambusa chinensis leaves, the extract of Houttuynia cordata, the extract of Chrysanthemum and the extract of Cnidium monnieri according to a certain proportion; Step 6, mixing powder and extract: adding fresh ginger extract, wormwood extract and mixed extract to the mixed powder in batches; Step 7, the mixture is mixed in the mixer for 1 hour, and the particles are obtained by spray drying; Step 8: Quality control: After the formula granules are made, identification and property inspection are carried out; Step 9. Packaging and storage: Put the light bamboo leaf granules into sterilized sealed bags and store them in a cool and dry place, avoiding direct sunlight and humid environment.

[0009] Preferably, the conditions for mixing the powder in step 4 are: the heating temperature is set to 50° C., coix seed rice powder is added first, and after heating for 5 minutes, red ginseng powder and adzuki bean powder are added, and stirring is continued during the process.

[0010] Preferably, the conditions for mixing the extracts in step 5 are: first add the Houttuynia cordata extract, heat at 40°C for 3 minutes, then add the chrysanthemum extract and the cnidium monnieri extract, heat at 35°C for 5 minutes, and finally add the loblolly leaf extract, heat at 40°C for 8 minutes, stirring continuously during the process.

[0011] Preferably, in step six, the powder and extract are mixed: fresh ginger extract is added to the mixed powder, heated at 35°C for 10 minutes, stirred evenly, then the mixed extract is added, heated at 40°C for 15 minutes, stirred evenly, then the wormwood extract is added, heated at 40°C for 15 minutes, and stirred evenly to form a mixture.

[0012] Preferably, the quality control process in step eight is as follows: take 1 g of the finished product of the light bamboo leaf formula granules, use a grinder to grind to 1 / 3 of the original volume, add 20 ml of 70% ethanol, use an ultrasonic machine with a power of 200 W and a frequency of 40 kHz for ultrasonic treatment for 20 minutes, and then filter with a triangular funnel and two layers of filter paper, evaporate the filtrate to 1 / 5 of the original volume, add 10 ml of water to the filter residue and let it stand for 20 minutes to dissolve, shake and extract with ethyl acetate 3 times, 20 ml each time, combine the ethyl acetate solution, evaporate to dryness, add 2 ml of 70% ethanol to the residue to dissolve it, and use the test solution; Identification and characterization: The retention time and peak area parameters of the test solution and the standard solution were compared by high performance liquid chromatography for qualitative and quantitative analysis.

[0013] Preferably, the storage temperature in step nine is: -5°C-10°C.

[0014] Compared with the prior art, the present invention provides a compound loquat leaf formula granule and a preparation method thereof, which has the following beneficial effects: 1. The present invention adds wormwood extract, fresh ginger extract and cnidium monnieri extract. The ginger extract in the formula provides the effects of warming the body and promoting blood circulation, which is helpful to improve coldness and indigestion. The wormwood extract in the formula granules plays a role in assisting the light bamboo leaves in clearing away heat and detoxifying, and can also increase the antibacterial property of the product, which is suitable for solving skin problems or enhancing immunity. The ginger extract and the wormwood extract are matched to neutralize the cold characteristics of the light bamboo leaves, so that the efficacy is adapted to patients with cold constitution and poor gastrointestinal function. The cnidium monnieri is used to dispel wind and dampness, kill insects and relieve itching. The coumarin contained in it has antifungal and antiviral effects, which adds anti-inflammatory and antipruritic functions to the light bamboo leaves formula granules. At the same time, by adjusting the dosage of the ginger extract and the cnidium monnieri extract in the formula, an anti-inflammatory and antipruritic formula is provided, while maintaining the effects of promoting digestion and warming the body, so as to meet the needs of consumers with cold constitution and poor gastrointestinal function. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 A flow chart is prepared for the present invention; DETAILED DESCRIPTION

[0016] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0017] See also Figure 1 A compound bamboo leaf formula granule, the bamboo leaf formula granule ingredients include: bamboo leaf extract, wormwood extract, houttuynia extract, chrysanthemum extract, cnidium monnieri extract, fresh ginger extract, red ginseng powder, adzuki bean powder, coix seed powder; The weight, functions and effects of the granular raw materials include: 20-25 parts of Bamboo Leaf Extract; Effect: Bamboo leaves have the effects of clearing away heat and promoting diuresis, cooling and relieving summer heat, and are helpful in treating symptoms of fever, irritability, and difficulty urinating. They also contain flavonoids that can regulate the body's water content and enhance the body's tolerance to high temperatures. Functions in the formula: As the largest ingredient in the formula, the extract of the light bamboo leaves provides the finished granules with heat-clearing and heat-relieving properties, making it suitable for use in summer or tropical climates; 5-7 parts of wormwood extract; Effects: Mugwort can be used to dispel cold and dampness, warm the meridians and stop bleeding, purify the air, refresh the mind, and also has antibacterial and antiviral effects; Efficacy in the formula: The wormwood extract in the formula granules plays a role in assisting the light bamboo leaves in clearing away heat and detoxifying, while increasing the antibacterial properties of the product, making it suitable for solving skin problems or enhancing immunity; 10-15 parts of Houttuynia cordata extract; Effect: Houttuynia cordata not only has the effects of clearing away heat and detoxifying and diuresis, but also has anti-inflammatory and anti-cancer properties; Effects in the formula: Houttuynia cordata extract can enhance the detoxification and anti-inflammatory effects of the overall formula granules, and is suitable for the treatment and prevention of urinary system related diseases; 8-11 parts of chrysanthemum extract; Effect: Chrysanthemum can clear away heat, detoxify and calm liver yang. It is also rich in anthocyanins, which helps protect eyesight and lower blood pressure, and has anti-inflammatory effects. Effects in the formula: Chrysanthemum extract is mainly used in the formula granules to enhance eye health and relieve eye fatigue and dryness caused by excessive liver fire; 5-9 parts of Cnidium monnieri extract; Effect: Cnidium monnieri is used to dispel wind and dampness, kill insects and relieve itching. The coumarin it contains has antifungal and antiviral effects. Benefits in the formula: Cnidium monnieri extract adds antifungal and antiviral properties to the formula, suitable for the relief of skin infections or itching; 2-5 parts of fresh ginger extract; Effects: Ginger helps improve blood circulation and digestive system function, and also has anti-inflammatory and antioxidant properties. Effects in the formula: Ginger extract in the formula mainly provides the effect of warming the body and promoting blood circulation, which helps to improve coldness and indigestion; 5-8 portions of red ginseng powder; Effect: Red mountain ginseng can enhance the body's immunity, improve physical strength and mental state; Functions in the formula: Red ginseng powder as an auxiliary ingredient can enhance physical strength and improve overall recovery and resistance; 14-15 parts of adzuki bean powder; Effect: Adzuki beans have the effects of promoting diuresis and reducing swelling, draining pus and detoxifying. They are rich in protein and dietary fiber and can be used as a light meal, which helps to lose weight and improve skin conditions. Functions in the formula: Adzuki bean powder mainly provides detumescence and detoxification functions in the formula, and is suitable for use in weight loss and beauty products; 6-9 parts of coix seed powder; Effect: Job's tears can be used to strengthen the spleen and remove dampness, clear away heat and discharge pus. It contains vitamins and minerals, which can help improve skin condition and eliminate edema. Benefits in formulas: Barley rice powder is used in formulas for beauty and to improve skin conditions.

[0018] The preparation process of the extract of Bamboo Leaves is as follows: S1.1, pretreatment: wash the fresh bamboo leaves, put them into an oven and dry them at 80℃ for 30min. After drying, the water content of the bamboo leaves is 5%. The purpose of this step is to retain 5% of the water, because too much water will affect the extraction of the effective ingredients in the bamboo leaves, while too low water content may cause the bamboo leaves to change in quality during the subsequent preparation process; S1.2, crushing and mixing: crush the dried bamboo leaves into powder using a traditional Chinese medicine crusher, and mix them evenly with distilled water at a mass ratio of 1:20 and soak for 12 hours; S1.3, extraction: add the powder of the light bamboo leaves into 50% ethanol, keep it at 40℃ for 40min, use a centrifuge, centrifuge at 2000 rpm for 30min, and let it stand for 2h after centrifugation; S1.4, filtration and concentration: the supernatant obtained after standing is added into a rotary evaporator for distillation and concentration; S1.5, drying: placing the concentrated extract into a vacuum dryer for 30 min to obtain a concentrated extract of the light bamboo leaf extract; The above steps combine a variety of different extraction technologies and process flows to ensure that the active ingredients of the bamboo leaf extract can be fully released and maintain high purity and activity.

[0019] The preparation process of wormwood extract is as follows: S2.1. Selection and cleaning: Select fresh, pest-free mugwort, clean it and remove impurities; S2.2, cutting: Cut the cleaned wormwood into pieces of 0.5cm-1.0cm to facilitate the subsequent extraction process; S2.3, soaking: Soak the cut wormwood in clean water for 6 hours to soften the wormwood and make it easier to extract the active ingredients; S2.4, extraction: put the soaked wormwood into the extraction machine, add 50% distilled water, set the heating temperature to 40°C, and set the extraction time to 30 minutes; S2.5, Filtration: After the extraction is completed, the extract is filtered using a microporous membrane filter to remove solid residues; S2.6. Concentration: The filtered extract is concentrated to 1% of the original volume using a vacuum concentration method to reduce the amount of solvent to obtain an wormwood extract and increase the concentration of the extract.

[0020] The preparation process of Cnidium monnieri extract is as follows: S3.1. Raw material preparation: Select mid-mature, pest-free Cnidium monnieri and clean them to remove impurities and dirt; S3.2, crushing: the cleaned Cnidium monnieri is crushed by a crusher, and the particle size of the crushed particles is 1mm-1.2mm, so as to facilitate the subsequent extraction process; S3.3, extraction: mix the crushed Cnidium monnieri particles with 50% ethanol in a ratio of 1:1, put into an extractor, set the heating temperature to 55°C, set the extraction time to 20 minutes, and use a glass rod to stir continuously during the process; S3.4, Filtration: After the extraction is completed, the Cnidium monnieri extract is filtered using a microporous membrane filter to remove solid residues; S3.5, concentration: the filtered Cnidium monnieri extract is concentrated to 1% of the original volume by vacuum concentration to reduce the amount of solvent, thereby obtaining a Cnidium monnieri extract concentrate and increasing the concentration of the extract; S3.6. Drying: The Cnidium monnieri extract concentrate is placed in a vacuum dryer for 2 hours to obtain the Cnidium monnieri extract.

[0021] A method for preparing compound granules of light bamboo leaves, the method for preparing the above-mentioned granules of light bamboo leaves comprises the following steps: Step 1, extraction: extract light bamboo leaves, wormwood, houttuynia cordata, chrysanthemum, cnidium monnieri and fresh ginger respectively; Step 2, grinding: Grind red ginseng, adzuki beans and coix seeds into powder with a particle size of 50 microns to 80 microns using a grinder; Step 3: Weighing: weigh the extracted and ground raw materials according to the formula ratio; Step 4, mixing powder: mix red ginseng powder, adzuki bean powder and coix seed rice powder evenly according to the proportion; Step 5, mixing the extracts: uniformly mixing the extract of Bambusa chinensis leaves, the extract of Houttuynia cordata, the extract of Chrysanthemum and the extract of Cnidium monnieri according to a certain proportion; Step 6, mixing powder and extract: adding fresh ginger extract, wormwood extract and mixed extract to the mixed powder in batches; Step 7, the mixture is mixed in the mixer for 1 hour, and the particles are obtained by spray drying; Step 8: Quality control: After the formula granules are made, identification and property inspection are carried out; Step 9. Packaging and storage: Put the light bamboo leaf granules into sterilized sealed bags and store them in a cool and dry place, avoiding direct sunlight and humid environment.

[0022] The conditions for mixing the powder in step 4 are: the heating temperature is set to 50°C, the coix seed rice powder is added first, and after heating for 5 minutes, the red ginseng powder and the red bean powder are added, and stirring is continued during the process.

[0023] The conditions for mixing the extracts in step 5 are as follows: first add the Houttuynia cordata extract, heat at 40°C for 3 minutes, then add the Chrysanthemum extract and the Cnidium monnieri extract, heat at 35°C for 5 minutes, and finally add the Lophatherum gracile extract, heat at 40°C for 8 minutes, stirring continuously during the process.

[0024] In step six, the powder and extract are mixed: the fresh ginger extract is added to the mixed powder, heated at 35°C for 10 minutes, stirred evenly, then the mixed extract is added, heated at 40°C for 15 minutes, stirred evenly, then the wormwood extract is added, heated at 40°C for 15 minutes, and stirred evenly to form a mixture.

[0025] Quality control process in step eight: take 1g of the finished product of the light bamboo leaf formula granule, use a grinder to grind it to 1 / 3 of the original volume, add 20ml of 70% ethanol, use an ultrasonic machine with a power of 200W and a frequency of 40kHz for 20 minutes, and then filter it with a triangular funnel and two layers of filter paper, evaporate the filtrate to 1 / 5 of the original volume, add 10ml of water to the filter residue and let it stand for 20min to dissolve, shake and extract with ethyl acetate 3 times, 20ml each time, combine the ethyl acetate solution, evaporate to dryness, and add 2ml of 70% ethanol to the residue to dissolve it as the test solution; Identification and characterization: The retention time and peak area parameters of the test solution and the standard solution were compared by high performance liquid chromatography for qualitative and quantitative analysis; Perform precipitation reaction, color reaction or fluorescence reaction test according to pharmacopoeia.

[0026] The storage temperature in step nine is: -5°C-10°C.

[0027] Example 1 The granule raw materials include, by weight: 24 parts of loblolly leaf extract; 6 parts of wormwood extract; 14 parts of houttuynia cordata extract; 11 parts of chrysanthemum extract; 8 parts of cnidium monnieri extract; 5 parts of fresh ginger extract; 6 parts of red ginseng powder; 14 parts of adzuki bean powder; and 6 parts of coix seed powder.

[0028] Example 2 The granule raw materials include, by weight: 20 parts of loblolly leaf extract; 6 parts of wormwood extract; 11 parts of houttuynia cordata extract; 8 parts of chrysanthemum extract; 8 parts of cnidium monnieri extract; 3 parts of fresh ginger extract; 7 parts of red ginseng powder; 14 parts of adzuki bean powder; and 6 parts of coix seed powder.

[0029] Comparative Example 1 The granule raw materials include, by weight: 24 parts of loblolly leaf extract; 14 parts of houttuynia cordata extract; 11 parts of chrysanthemum extract; 8 parts of cnidium monnieri extract; 5 parts of fresh ginger extract; 6 parts of red ginseng powder; 14 parts of adzuki bean powder; and 6 parts of coix seed powder.

[0030] Comparative Example 2 The granule raw materials include, by weight: 24 parts of loblolly leaf extract; 6 parts of wormwood extract; 14 parts of houttuynia cordata extract; 11 parts of chrysanthemum extract; 8 parts of cnidium monnieri extract; 6 parts of red ginseng powder; 14 parts of adzuki bean powder; and 6 parts of coix seed powder.

[0031] Comparative Example 3 The granule raw materials include, by weight: 20 parts of light bamboo leaf extract; 6 parts of wormwood extract; 11 parts of houttuynia cordata extract; 8 parts of chrysanthemum extract; 3 parts of fresh ginger extract; 7 parts of red ginseng powder; 14 parts of red bean powder; and 6 parts of coix seed powder.

[0032] Comparison between Example 1 and Comparative Example 1: Example 1 contains 6 parts of wormwood extract, while Comparative Example 1 does not contain wormwood extract. The addition of wormwood extract makes the light bamboo leaf formula granules have the following effects: enhancing the antibacterial property of the granules, improving the fragrance and improving the redness and swelling of the skin; Comparison of Example 1 and Comparative Example 2: In Example 1, fresh ginger extract was added and the amount of red ginseng powder was adjusted. The finished granule product not only ensured the heat-clearing effect, but also had the effects of warming and promoting digestion. In Comparative Example 2, by increasing the amount of loblolly leaves, houttuynia cordata and chrysanthemum extracts, the effects of clearing heat, detoxifying and calming liver yang were better. However, due to the lack of fresh ginger extract, the finished granule product did not have the effects of warming and promoting digestion.

[0033] Comparison of Example 2 and Comparative Example 3: Comparative Example 3 has the advantages of reducing costs and simple preparation by removing fresh ginger extract and cnidium monnieri extract from the formula, but the finished particles lose the effects of ginger and cnidium monnieri in promoting blood circulation, improving digestion and relieving inflammation and itching. Example 2 contains a complete formula of ginger extract and cnidium monnieri extract, which can fully exert the effects of ginger extract and cnidium monnieri in promoting blood circulation, improving digestion and relieving inflammation and itching, and is suitable for a wider range of application needs.

[0034] The present invention provides an anti-inflammatory and antipruritic formula by adding wormwood extract, fresh ginger extract and cnidium monnieri extract and adjusting the dosage of the ginger extract and the cnidium monnieri extract in the formula, while maintaining the effects of promoting digestion and warming the body, so as to meet the needs of consumers with cold constitution and poor gastrointestinal function.

[0035] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A compound granule of bamboo leaf, characterized in that: The ingredients of the bamboo leaf formula granules include bamboo leaf extract, wormwood extract, houttuynia cordata extract, chrysanthemum extract, cnidium monnieri extract, fresh ginger extract, red ginseng powder, adzuki bean powder and coix seed powder; The granular raw materials include, by weight: 20-25 parts of loblolly leaf extract; 5-7 parts of wormwood extract; 10-15 parts of houttuynia cordata extract; 8-11 parts of chrysanthemum extract; 5-9 parts of cnidium monnieri extract; 2-5 parts of fresh ginger extract; 5-8 parts of red ginseng powder; 14-15 parts of adzuki bean powder; and 6-9 parts of coix seed powder.

2. The compound loquat leaf formula granules according to claim 1, characterized in that: The preparation process of the Bambusa longituba extract is as follows: S1.1, Pretreatment: Wash the fresh bamboo leaves, put them into an oven and dry them at 80℃ for 30min. After drying, the water content of the bamboo leaves is 5%; S1.2, crushing and mixing: crush the dried bamboo leaves into powder using a traditional Chinese medicine crusher, and mix them evenly with distilled water at a mass ratio of 1:20 and soak for 12 hours; S1.3, extraction: add the powder of the light bamboo leaves into 50% ethanol, keep it at 40℃ for 40min, use a centrifuge, centrifuge at 2000 rpm for 30min, and let it stand for 2h after centrifugation; S1.4, filtration and concentration: the supernatant obtained after standing is added into a rotary evaporator for distillation and concentration; S1.

5. Drying: The concentrated extract was placed in a vacuum dryer for 30 minutes to obtain a concentrated extract of the Bambusa chinensis leaves.

3. The compound loquat leaf formula granules according to claim 1, characterized in that: The preparation process of the wormwood extract is as follows: S2.

1. Selection and cleaning: Select fresh, pest-free mugwort and clean it thoroughly; S2.2, cutting: cut the cleaned mugwort into pieces of 0.5cm-1.0cm; S2.3, soaking: Soak the cut mugwort in clean water for 6 hours; S2.4, extraction: put the soaked wormwood into the extraction machine, add 50% distilled water, set the heating temperature to 40°C, and set the extraction time to 30 minutes; S2.5, Filtration: After the extraction is completed, the extract is filtered using a microporous membrane filter to remove solid residues; S2.

6. Concentration: The filtered extract is concentrated to 1% of the original volume using a vacuum concentration method to reduce the amount of solvent to obtain an wormwood extract.

4. The compound loquat leaf formula granule according to claim 1, characterized in that: The preparation process of the Cnidium monnieri extract is as follows: S3.

1. Raw material preparation: Select mid-mature, pest-free Cnidium monnieri and clean them; S3.2, crushing: crush the cleaned Cnidium monnieri with a crusher, and the particle size of the crushed particles is 1mm-1.2mm; S3.3, extraction: mix the crushed Cnidium monnieri particles with 50% ethanol in a ratio of 1:1, put into an extractor, set the heating temperature to 55°C, set the extraction time to 20 minutes, and use a glass rod to stir continuously during the process; S3.4, Filtration: After the extraction is completed, the Cnidium monnieri extract is filtered using a microporous membrane filter to remove solid residues; S3.5, concentration: the filtered Cnidium monnieri extract is concentrated to 1% of the original volume by vacuum concentration to reduce the amount of solvent, thereby obtaining a Cnidium monnieri extract concentrate; S3.

6. Drying: The Cnidium monnieri extract concentrate is placed in a vacuum dryer for 2 hours to obtain the Cnidium monnieri extract.

5. A method for preparing compound loquat leaf granules, characterized in that: The preparation method is used to prepare the light bamboo leaf formula granules described in right 1, and the preparation method comprises the following steps: Step 1, extraction: extract light bamboo leaves, wormwood, houttuynia cordata, chrysanthemum, cnidium monnieri and fresh ginger respectively; Step 2, grinding: Grind red ginseng, adzuki beans and coix seeds into powder with a particle size of 50 microns to 80 microns using a grinder; Step 3: Weighing: weigh the extracted and ground raw materials according to the formula ratio; Step 4, mixing powder: mix red ginseng powder, adzuki bean powder and coix seed rice powder evenly according to the proportion; Step 5, mixing the extracts: uniformly mixing the extract of Bambusa chinensis leaves, the extract of Houttuynia cordata, the extract of Chrysanthemum and the extract of Cnidium monnieri according to a certain proportion; Step 6, mixing powder and extract: adding fresh ginger extract, wormwood extract and mixed extract to the mixed powder in batches; Step 7, the mixture is mixed in the mixer for 1 hour, and the particles are obtained by spray drying; Step 8: Quality control: After the formula granules are made, identification and property inspection are carried out; Step 9. Packaging and storage: Put the light bamboo leaf granules into sterilized sealed bags and store them in a cool and dry place, avoiding direct sunlight and humid environment.

6. The method for preparing the compound loquat leaf granules according to claim 5, characterized in that: The conditions for mixing the powder in step 4 are: the heating temperature is set to 50° C., coix seed rice powder is added first, and after heating for 5 minutes, red ginseng powder and adzuki bean powder are added, and stirring is continued during the process.

7. The method for preparing the compound loquat leaf granules according to claim 5, characterized in that: The conditions for mixing the extracts in step 5 are as follows: first add the Houttuynia cordata extract, heat at 40°C for 3 minutes, then add the Chrysanthemum extract and the Cnidium monnieri extract, heat at 35°C for 5 minutes, and finally add the Lophatherum gracile extract, heat at 40°C for 8 minutes, with continuous stirring during the process.

8. The method for preparing the compound loquat leaf granules according to claim 5, characterized in that: In the step six, the powder and extract are mixed: fresh ginger extract is added to the mixed powder, heated at 35°C for 10 minutes, stirred evenly, then the mixed extract is added, heated at 40°C for 15 minutes, stirred evenly, then the wormwood extract is added, heated at 40°C for 15 minutes, and stirred evenly to form a mixture.

9. The method for preparing the compound loquat leaf granules according to claim 5, characterized in that: The quality control process in step eight is as follows: take 1 g of the finished product of the light bamboo leaf formula granules, grind it to 1 / 3 of the original volume using a grinder, add 20 ml of 70% ethanol, use an ultrasonic machine with a power of 200 W and a frequency of 40 kHz for 20 minutes for ultrasonic treatment, and then filter it with a triangular funnel and two layers of filter paper, evaporate the filtrate to 1 / 5 of the original volume, add 10 ml of water to the filter residue and let it stand for 20 minutes to dissolve, shake and extract with ethyl acetate 3 times, 20 ml each time, combine the ethyl acetate solution, evaporate to dryness, add 2 ml of 70% ethanol to the residue to dissolve it, and use it as the test solution; Identification and characterization: The retention time and peak area parameters of the test solution and the standard solution were compared by high performance liquid chromatography for qualitative and quantitative analysis.

10. The method for preparing the compound loquat leaf granules according to claim 5, characterized in that: The storage temperature in step nine is: -5°C-10°C.

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