A thrombin solution virus inactivation device

Abstract

The application discloses a thrombin solution virus inactivation device, which comprises a pump body one and a rack, the input end of the pump body one is communicated with a liquid storage device for storing thrombin solution through a liquid inlet pipe, the output end of the pump body one is provided with a liquid outlet pipe one, a protective shell is arranged at the middle position of the rack, a light transmission cylinder for placing the thrombin solution is arranged in the protective shell, a plurality of pairs of semicircular protrusions for stirring the liquid are arranged on the inner wall of the light transmission cylinder alternately, a secondary transmission gear is fixedly arranged at one end of the light transmission cylinder, the liquid outlet pipe one penetrates through the secondary transmission gear and extends into the light transmission cylinder, a plurality of ultraviolet lamps are arranged in the annular distribution between the light transmission cylinder and the protective shell, a driving motor is arranged at the top of the rack, a primary transmission gear corresponding to the secondary transmission gear is fixedly connected to the output end of the driving motor, and the primary transmission gear and the secondary transmission gear are transmissionally connected through a transmission belt, the semicircular protrusions arranged on the inner wall of the light transmission cylinder alternately can generate a turbulence effect on the thrombin solution in the light transmission cylinder when the light transmission cylinder rotates, the solution is promoted to be stirred more uniformly, the ultraviolet light can be refracted, the optical path length is increased, the ultraviolet light is more fully contacted with the solution, and thus the virus inactivation efficiency is improved.

Description

Technical Field

[0001] The invention belongs to the technical field of virus inactivation devices, in particular to a thrombin solution virus inactivation device. Background Art

[0002] Thrombin is a key serine protease that plays a vital role in blood coagulation. It is primarily activated in the blood by activated factor II (also known as prothrombin), a process that forms part of the body's natural hemostasis mechanism. When tissue damage causes a rupture in a blood vessel wall, thrombin rapidly aggregates at the site of the wound and catalyzes the conversion of fibrinogen into insoluble fibrin, forming a stable clot that prevents further bleeding. Thrombin also promotes platelet aggregation, further strengthening the clot structure and ensuring effective closure of the damaged vessel.

[0003] The main component of thrombin solution is thrombin. In clinical practice, thrombin solution is usually used for local hemostasis, especially in minor surgery or dental surgery, to help control bleeding and promote wound healing.

[0004] The Chinese patent document "CN209075548U, a sandwich sleeve-shaped inactivation tube and its ultraviolet virus inactivation device" includes an inactivation tube body, which is composed of a large-diameter light-transmitting sleeve and a small-diameter light-transmitting sleeve. The large-diameter light-transmitting sleeve is located on the outer peripheral side of the small-diameter light-transmitting sleeve, and the upper and lower ends of the large-diameter light-transmitting sleeve and the small-diameter light-transmitting sleeve are in the same plane and sealed with a glass plate made of a light-transmitting material. A sealed space is defined between the large-diameter light-transmitting sleeve and the small-diameter light-transmitting sleeve; an inlet for the inactivation liquid to be inactivated is provided in the horizontal direction at the bottom of the inactivation tube body, and an outlet for the inactivated liquid to flow out is provided in the horizontal direction at the top of the inactivation tube body; the inlet and the outlet are connected to the sealed space.

[0005] However, its spiral UV lamp design leads to uneven light irradiation. Specifically, in the spiral structure, the intensity of the light varies at different locations, which may result in the virus not being effectively inactivated in certain areas, thus affecting the overall inactivation effect. At the same time, the device may not be able to completely inactivate the virus using only UV light. To achieve complete inactivation, long-term UV irradiation is required, which reduces the inactivation efficiency. If the virus inactivation is judged solely based on the conclusions drawn from the experiment, and the virus solution is directly withdrawn after the predetermined time, there may be a risk of incomplete inactivation, which may ultimately lead to substandard product quality. Summary of the Invention

[0006] The object of the present invention is to provide a thrombin solution virus inactivation device to solve the problems raised in the above background technology.

[0007] To achieve the above object, the present application provides the following technical solutions:

[0008] A thrombin solution virus inactivation device, including pump body one and frame, the input end of the pump body one is communicated with the liquid storage device for storing thrombin solution through the liquid inlet pipe, the output end of the pump body one is installed with liquid outlet pipe one, the middle position of the frame is installed with protective shell, the protective shell is provided with light transmission cylinder for placing thrombin solution, the inner wall of the light transmission cylinder is staggered with a plurality of pairs of semicircular protrusions for stirring effect of liquid, one end of the light transmission cylinder is fixedly installed with auxiliary transmission gear, the liquid outlet pipe one passes through the auxiliary transmission gear and extends to the inside of the light transmission cylinder, the thrombin solution is pumped into the light transmission cylinder through the pump body one, a plurality of annular ultraviolet lamps are arranged between the light transmission cylinder and the protective shell, the ultraviolet light emitted by the ultraviolet lamp is used for inactivating the virus of the thrombin solution, the driving motor is installed on the top of the frame, the output end of the driving motor is fixedly connected with the main transmission gear corresponding to the auxiliary transmission gear, the main transmission gear and the auxiliary transmission gear are drivingly connected through the transmission belt, so that the driving motor drives the light transmission cylinder to rotate, and the thrombin solution is constantly turned over with the rotation of the light transmission cylinder, the protective shell is provided with an opening window, the side wall of the light transmission cylinder is installed with a self-sealing joint corresponding to the opening window, the self-sealing joint can be inserted into the sampler to extract the thrombin solution from the inside of the light transmission cylinder to detect the virus inactivation effect, the other end of the light transmission cylinder is provided with liquid outlet pipe two, the other end of the liquid outlet pipe two is connected with pump body two, and the thrombin solution with inactivated virus is pumped out through the pump body two.

[0009] The input amount of the thrombin solution, the inactivation time of the virus, the rotation speed and the number of turns of the light transmission cylinder and other data of the pre-experiment are input into the control system, the control system controls the pump body one to pump the thrombin solution from the liquid storage device into the light transmission cylinder according to the input parameters, at the same time, the driving motor is started, the light transmission cylinder rotates at a predetermined speed, when the preset inactivation time is reached, the light transmission cylinder automatically stops rotating, at this time, the self-sealing joint corresponds to the opening window on the protective shell, the opening window can be opened by the staff to extract the treated thrombin solution from the inside of the light transmission cylinder through the sampler inserted into the self-sealing joint for inspection, if the test result meets the standard, the pump body two is started to pump the treated solution out to the external liquid storage device, if the test result does not meet the standard, the control system controls the light transmission cylinder to continue rotating until the inactivation condition is met.

[0010] Further, the electronic metering valve one is arranged on the liquid outlet pipe one, and the electronic metering valve two is arranged on the liquid outlet pipe two, which are respectively used for detecting and controlling the liquid inlet amount and the liquid outlet amount of the thrombin solution.

[0011] Furthermore, a rotating bearing 1 is fixedly mounted on the outer end of the auxiliary transmission gear, and the inner ring of the rotating bearing 1 is sealed and clamped with the liquid outlet pipe 1. A rotating bearing 2 is fixedly mounted on the liquid outlet end of the light-transmitting tube, and the inner ring of the rotating bearing 2 is sealed and clamped with the liquid outlet pipe 2 to ensure that the liquid outlet pipe 1 and the liquid outlet pipe 2 do not rotate together with the light-transmitting tube.

[0012] Furthermore, the inner rings of the rotating bearing 1 and the rotating bearing 2 are both provided with T-slots, and sealing rings are placed in the T-slots. The liquid outlet pipe 1 and the liquid outlet pipe 2 are both provided with inner grooves, and the other end of the sealing ring is stuck in the inner groove to form a sealing structure.

[0013] Furthermore, a fixed bearing is provided on the second outer sleeve of the rotating bearing, and a support platform for installing the fixed bearing is provided at the lower end of the protective shell, which is used to rotatably support the other end of the light-transmitting tube.

[0014] Furthermore, sealing gaskets are placed between the first rotating bearing and the auxiliary transmission wheel, between the auxiliary transmission wheel and the light-transmitting cylinder, and between the second rotating bearing and the light-transmitting cylinder to ensure the sealing effect of the device and prevent the solution from leaking.

[0015] Furthermore, the sampler includes a top cover, the lower end of which is rotatably connected to a detection cup, one side of the top cover is provided with a sampling needle connected to the detection cup, and the other end of the top cover is provided with a micro diaphragm liquid pump corresponding to the sampling needle, and the thrombin solution is pumped from the sampling needle to the sampling cup through the micro diaphragm liquid pump.

[0016] Furthermore, a manual valve is provided between the sampling needle and the top cover.

[0017] Furthermore, a drawer cabinet capable of receiving ultraviolet light is provided at the lower end of the protective shell, and the sampler after testing is placed in the drawer cabinet and sterilized by ultraviolet light.

[0018] Beneficial effects of the present invention:

[0019] The present invention allows the operator to perform sample testing after each inactivation cycle, ensuring that only qualified products enter the next step of the process, effectively avoiding the generation of unqualified products.

[0020] By staggering a number of semicircular protrusions on the inner wall of the light-transmitting cylinder, when the light-transmitting cylinder rotates, it can produce a turbulent effect on the thrombin solution inside, causing the solution to churn more evenly. It can also produce a refracting effect on ultraviolet light, increasing the optical path length and allowing the ultraviolet light to more fully contact the solution, thereby improving the efficiency of virus inactivation.

[0021] The circularly distributed UV lamps can provide a more uniform light intensity, ensuring that the viruses in the thrombin solution are evenly and effectively inactivated, reducing the problem of incomplete inactivation caused by uneven light.

[0022] By rotating the light-transmitting cylinder, the thrombin solution is continuously stirred, which increases the contact area and contact time between the solution and ultraviolet light and improves the inactivation efficiency.

[0023] Other features and advantages of the present invention will be described in detail in the following detailed description. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 : The overall structure of the present invention Figure 1 .

[0025] Figure 2 : The overall structure of the present invention Figure 2 .

[0026] Figure 3 : Cross-sectional view of the present invention Figure 1 .

[0027] Figure 4 : Cross-sectional view of the present invention Figure 2 .

[0028] Figure 5 : The light-transmitting cylinder of the present invention is connected with the driving motor structure diagram.

[0029] Figure 6 : Exploded view of the connection between the light-transmitting cylinder and the driving motor of the present invention.

[0030] Figure 7 : A cross-sectional view of a rotary bearing of the present invention.

[0031] Figure 8 : The light-transmitting tube and the driving motor connection structure of the present invention Figure 2 .

[0032] Figure 9 :The light-transmitting tube of the present invention is connected to the driving motor to explode Figure 2 .

[0033] Figure 10 : Two sectional views of the rotary bearing of the present invention.

[0034] Figure 11 : Sampling schematic diagram of the present invention.

[0035] Figure 12 : Sampler schematic diagram of the present invention.

[0036] Figure numerals: 1, pump body 1; 2, frame; 3, liquid storage device; 4, protective shell; 5, drive motor; 6, light-transmitting tube; 7, pump body 2; 9, sampler; 11, liquid inlet pipe; 12, liquid outlet pipe 1; 41, ultraviolet lamp; 42, switch window; 43, pull-out cabinet; 44, support platform; 45, Hall sensor; 51, auxiliary transmission wheel; 52, main transmission wheel; 53, transmission belt; 61, self-sealing joint; 62, semicircular protrusion ; 63. Rotating bearing 1; 64. Rotating bearing 2; 65. Fixed bearing; 66. Sealing gasket; 67. Magnet; 71. Liquid outlet pipe 2; 91. Top cover; 92. Test cup; 93. Sampling needle; 94. Micro diaphragm liquid pump; 95. Manual valve; 121. Inner groove; 122. Air inlet pipe; 123. Sealing cover; 124. Electronic metering valve 1; 631. T-slot; 632. Sealing ring; 711. Electronic metering valve 2. DETAILED DESCRIPTION

[0037] The technical solutions in the embodiments of the present invention will be described clearly and completely below with reference to the accompanying drawings in the embodiments of the present invention.

[0038] Please refer to Figure 1-12 ;

[0039] The utility model provides a thrombin solution virus inactivation device, including pump body no. 1 and frame 2, the input end of pump body no. 1 is connected with the liquid storage device 3 for storing thrombin solution through the liquid inlet pipe 11, the output end of pump body no. 1 is installed with liquid outlet pipe no. 12, the middle of frame 2 is installed with protective shell 4, be equipped with the light transmission cylinder 6 for placing thrombin solution in protective shell 4, preferably, the light transmission cylinder 6 is made of synthetic quartz material, synthetic quartz not only has the characteristics of high transparency and good ultraviolet transmittance, also has higher mohs hardness grade, which means that the material can withstand certain mechanical stress, and is not easy to wear or break, ensure the stability and durability of light transmission cylinder 6 when rotating, the inner wall of light transmission cylinder 6 is staggered with a plurality of semicircular protrusions 62, the setting is to produce the turbulence effect to the thrombin solution in the light transmission cylinder 6 when rotating, promote the solution to turn over more evenly, preferably, semicircular protrusion 62 is integrally formed with light transmission cylinder 6 structure, without additional joint or connecting point, this design not only enhances the overall stability of structure, also avoids the pollution risk that possibly produces because of joint or welding place, preferably, the semicircular protrusion is concave on the outside and convex on the inside, the semicircular protrusion 62 made of synthetic quartz can also refract ultraviolet light, increase the optical path length, make ultraviolet light more fully contact with the solution, thereby improve the efficiency of virus inactivation, one end of light transmission cylinder 6 is fixedly installed with auxiliary transmission gear 51, and liquid outlet pipe no. 12 passes through auxiliary transmission gear and extends to the inside of light transmission cylinder 6, thrombin solution is pumped to the inside of light transmission cylinder 6 through pump body no. 1, a plurality of annular distribution ultraviolet lamps 41 are arranged between light transmission cylinder 6 and protective shell 4, ultraviolet lamp 41 is strip-shaped lamp tube, ultraviolet light emitted by ultraviolet lamp 41 is used to inactivate thrombin solution virus, it is needful to indicate that protective shell 4 is made of stainless steel material, not only can prevent ultraviolet light leakage, protect the safety of operator, and its firmness also makes protective shell 4 can long -term use, the both ends of protective shell 4 are designed as detachable, facilitate the installation and maintenance of internal components, frame 2 top is installed with drive motor 5, drive motor 5 is a kind of common equipment, here do not make too much description, the output end of drive motor 5 is fixedly connected with the main transmission gear 52 corresponding with auxiliary transmission gear 51, and main transmission gear 52 is drivenly connected with auxiliary transmission gear 51 through transmission belt 53, thereby realize drive motor 5 drives light transmission cylinder 6 to rotate, make thrombin solution constantly turn over along with the rotation of light transmission cylinder 6, ensure that part of solution is in full contact with ultraviolet light, improve the effect of virus inactivation, switch window 42 is equipped on protective shell 4, switch window 42 is normally closed, and self-sealing joint 61 corresponding with switch window 42 is installed on the side wall of light transmission cylinder 6, open switch window 42, self-sealing joint 61 can be inserted into sampler 9 to extract and detect thrombin solution in light transmission cylinder 6, self-sealing joint 61 is used to extract and detect thrombin solution in light transmission cylinder 6 under the premise of not breaking the sealing, the inside of self-sealing joint 61 is equipped with elastic sealing element, when sampling needle 93 is inserted,The seal will be squeezed open, allowing the solution to flow out; once the sampling needle 93 is pulled out, the seal will immediately return to its original state, re-seal the joint, and maintain the sealed state of the internal environment of the light-transmitting tube 6. It is explained here that the ultraviolet lamp 41 irradiates the thrombin solution for a certain period of time, with the position corresponding to the self-sealing joint 61 and the switch window 42 as the initial position, and the drive motor 5 will drive the light-transmitting tube 6 to rotate a fixed number of circles according to the irradiation time. After rotating to the number of circles, the drive motor 5 stops to ensure that the self-sealing interface corresponds to the switch window 42. For example, it takes 5 minutes to inactivate the virus in the thrombin solution. After the ultraviolet lamp 41 irradiates for 5 minutes, the drive motor 5 continues to rotate to the initial position and stops rotating. After the drive motor 5 stops rotating, the ultraviolet lamp 41 stops irradiating. Thereafter, the operator can use the sampler 9 to insert the self-sealing joint 61 into the light-transmitting tube. 6 extracts thrombin solution from the inside to test the virus inactivation effect to prevent the ultraviolet light emitted by the ultraviolet lamp 41 from causing harm to the human body. The other end of the light-transmitting cylinder 6 is penetrated by a second liquid outlet pipe 71, and the other end of the liquid outlet pipe 71 is connected to a second pump body 7. If the virus inactivation effect of the thrombin solution detected meets the standard, the thrombin solution with completed virus inactivation is extracted to an external liquid storage device through the second pump body 7. If the virus inactivation effect of the thrombin solution detected does not meet the standard, the switch window 42 is closed, the drive motor 5 and the ultraviolet lamp 41 are turned on, and the above settings are repeated for repeated inactivation until the inactivation conditions are met. At the same time, since the inactivation effect of the ultraviolet lamp 41 is not good after 5 minutes of irradiation, the next inactivation time can be appropriately extended and the number of rotations of the light-transmitting cylinder 6 can be increased to reduce unnecessary repeated testing.

[0040] Specifically, the optimal input amount of thrombin solution, the required virus inactivation time, the rotation speed and the number of rotations of the light-transmitting cylinder 6 are determined in advance through experiments, and these data are input into the control system. The control system starts the pump body 1 according to the input parameters, and the thrombin solution in the liquid storage device 3 is pumped into the light-transmitting cylinder 6 according to the preset amount. At the same time, the control system activates the drive motor 5, which drives the secondary transmission wheel 51 through the transmission belt 53, so that the light-transmitting cylinder 6 starts to rotate at the preset speed. The rotation of the light-transmitting cylinder 6 causes the solution to churn in it, ensuring that part of the solution is in sufficient contact with ultraviolet light. In the process of rotation of the light-transmitting cylinder 6, the ultraviolet lamp 41 continuously emits ultraviolet light to inactivate the viruses in the solution. When the preset inactivation time is reached and the light-transmitting cylinder 6 rotates to the initial position, the control system stops the motor to make the light-transmitting cylinder 6 stationary. After the light-transmitting cylinder 6 stops rotating, the self-sealing joint 61 aligns with the switch window 42 on the protective shell 4. At this time, the operator can open the switch window 42 and use the sampler 9 to extract the treated solution from the light-transmitting cylinder 6 through the self-sealing joint 61 for testing. If the test result shows that the virus inactivation effect of the solution meets the expected standard, the control system will start the pump body 2 7 to pump the treated solution that meets the standard to the external liquid storage device. If the test result shows that the virus inactivation effect of the solution does not meet the standard, the control system will start the rotation process of the light-transmitting cylinder 6 again until the solution meets the inactivation requirements, thereby realizing the automatic control of the thrombin solution virus inactivation process and improving the virus inactivation effect and work efficiency of the thrombin solution.

[0041] In addition, the ultraviolet lamps 41 are in electrical communication with the external control system, and the irradiation wavelength of the ultraviolet lamps 41 can be controlled by the external control system to adapt to different types of virus inactivation requirements and ensure the optimization of the inactivation effect.

[0042] The outlet pipe one 12 and the outlet pipe two 71 are both L-shaped, and the horizontally extending end of each is located on the lower end face inside the light-transmitting cylinder 6. This design ensures that the solution can be directly injected into the bottom of the cylinder when entering the light-transmitting cylinder 6, thereby avoiding the adhesion or generation of bubbles on the inner wall of the cylinder, ensuring uniform distribution of the solution, and reducing the residue of the solution at the bottom when being extracted, so as to ensure the recovery of as much treated solution as possible, improve the processing efficiency and thoroughness.

[0043] In one embodiment, a magnet 67 is installed near the self-sealing joint 61 of the light-transmitting tube 6, and a Hall sensor 45 is installed on the inner wall of the protective shell 4. In the initial state, the position of the magnet 67 should correspond to the position of the Hall sensor 45. The Hall sensor 45 senses the position of the magnet 67. When the irradiation time of the ultraviolet lamp 41 reaches the set value, the Hall sensor 45 detects the position of the magnet 67 and transmits this signal to the external control system. After receiving the signal from the Hall sensor 45, the external control system controls the drive motor 5 to decelerate until the position of the magnet 67 once again coincides with the position of the Hall sensor 45. At this point, the self-sealing joint 61 on the light-transmitting tube 6 is exactly aligned with the switch window 42 on the protective shell 4. When the Hall sensor 45 detects that the magnet 67 has returned to the initial position, the control system immediately stops the drive motor 5, ensuring that the light-transmitting tube 6 stops at the correct position, thereby accurately aligning the self-sealing joint 61 with the switch window 42, and ensuring that the light-transmitting tube 6 can accurately stop at the predetermined position after each inactivation treatment.

[0044] In one embodiment, an electronic metering valve 124 is provided on the liquid outlet pipe 12, and an electronic metering valve 2 711 is provided on the liquid outlet pipe 2 71. Before injecting the thrombin solution into the light-transmitting cylinder 6, the electronic metering valve 124 is first closed, and the electronic metering valve 2 711 is opened. The air in the light-transmitting cylinder 6 is extracted by using the pump body 2 7, and then the electronic metering valve 2 711 is closed and the electronic metering valve 124 is opened. The thrombin solution can be pumped into the light-transmitting cylinder 6 through the pump body 1. When the virus inactivation of the thrombin solution is completed, the electronic metering valve 2 711 is opened and the electronic metering valve 124 is closed. The thrombin solution is extracted. At the same time, the two electronic metering valves can also be used to detect and control the inlet and outlet amounts of the thrombin solution. When the electronic metering valve 124 detects that the injection amount of the thrombin solution reaches the set amount, the electronic metering valve 124 automatically closes and transmits the signal to the control system, which automatically closes the pump body 1 through the control system to avoid excessive thrombin solution injected into the light-transmitting tube 6 and affecting the inactivation effect. When the thrombin solution after virus inactivation is extracted, the electronic metering valve 2 711 can detect the outlet amount of the liquid, which is convenient for the operator to observe whether the thrombin solution is completely extracted.

[0045] In addition, when the pump body 2 7 draws liquid, a negative pressure effect will be generated due to insufficient air in the light-transmitting cylinder 6, resulting in the inability to draw out the solution. For this reason, an air inlet pipe is provided in the pipeline between the electronic metering valve 124 and the light-transmitting cylinder 6. The air inlet pipe 122 is connected to the liquid outlet pipe 12 to form a three-way pipe structure. An air inlet is provided on the air inlet pipe 122, and a sealing cover 123 is rotatably connected to the air inlet. Before the pump body 1 is infused, the sealing cover 123 is screwed on to prevent the solution from spraying out from the air inlet. When the pump body 2 7 draws the solution, the sealing cover 123 can be opened to ensure air circulation and ensure smooth extraction of the solution.

[0046] In one embodiment, a rotary bearing 63 is fixedly mounted on the outer end of the auxiliary transmission wheel 51, and the inner ring of the rotary bearing 63 is sealed and clamped with the liquid outlet pipe 12, so that the liquid outlet pipe 12 will not be affected by the rotation when the light-transmitting cylinder 6 rotates and remains stable. A rotary bearing 2 64 is fixedly mounted on the liquid outlet end of the light-transmitting cylinder 6, and the inner ring of the rotary bearing 2 64 is sealed and clamped with the liquid outlet pipe 2 71, ensuring that the liquid outlet pipe 2 71 can remain fixed during the rotation of the light-transmitting cylinder 6 and will not be affected by the rotation. Such a design not only ensures the stability of the liquid outlet pipe, but also avoids mechanical damage or leakage caused by rotation, thereby improving the reliability and safety of the entire device.

[0047] Furthermore, a T-slot 631 is provided in the inner ring of the rotating bearing 1 63 and the rotating bearing 2 64, and a sealing ring 632 is placed in the T-slot 631. The shape of the sealing ring 632 matches the T-slot 631, which can maintain stability when the rotating bearing rotates to prevent leakage. The liquid outlet pipe 1 12 and the liquid outlet pipe 2 71 are both provided with an inner groove 121, and the other end of the sealing ring 632 is stuck in the inner groove 121. This design not only ensures that the liquid outlet pipe is fixed when the light-transmitting tube 6 rotates, but also ensures that no leakage occurs during the rotation process.

[0048] In one embodiment, a fixed bearing 65 is provided outside the second rotating bearing 64, and a support platform 44 for installing the fixed bearing 65 is provided at the lower end of the protective shell 4. The other end of the light-transmitting tube 6 is rotationally supported by the fixed bearing 65, thereby ensuring the stability of the light-transmitting tube 6 during rotation.

[0049] Since all the parts are made of hard materials, there will be gaps where the parts are connected, and the solution may leak from these gaps. Therefore, sealing gaskets 66 are placed between the rotating bearing 1 63 and the auxiliary transmission wheel 51, between the auxiliary transmission wheel 51 and the light-transmitting cylinder 6, and between the rotating bearing 2 64 and the light-transmitting cylinder 6. These sealing gaskets 66 effectively isolate the gaps between the various components, ensuring that the solution will not leak from the gaps in the device, thereby improving the sealing effect of the device.

[0050] In one embodiment, the sampler 9 includes a top cover 91, the lower end of which is rotatably connected to a test cup 92. The test cup 92 is removable and can be removed for testing the solution. A sampling needle 93 is provided on one side of the top cover 91 and communicates with the test cup 92. A micro-diaphragm liquid pump 94, preferably model TF30A-A, is provided at the other end of the top cover 91 to correspond with the sampling needle 93. The micro-diaphragm liquid pump 94 pumps the thrombin solution into the sampling cup. To prevent solution spraying, the power of the micro-diaphragm liquid pump 94 should not be too high. A solution collection tool is connected to the liquid outlet to ensure safe operation and avoid liquid splashing. Furthermore, a manual valve 95 is provided between the sampling needle 93 and the top cover 91. The provision of the manual valve 95 ensures controllable sampling and avoids solution waste.

[0051] In one embodiment, a drawer cabinet 43 capable of receiving ultraviolet light is provided at the lower end of the protective shell 4. The sampler 9 after testing is placed in the drawer cabinet 43 and sterilized by ultraviolet light.

[0052] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above and that the invention can be embodied in other specific forms without departing from the spirit or essential characteristics of the invention. Therefore, the embodiments should be considered in all respects as illustrative and non-restrictive, and the scope of the invention is defined by the appended claims, not the foregoing description, and all variations within the meaning and range of equivalents of the claims are intended to be included therein. Any reference sign in a claim should not be construed as limiting the claim to which it relates.

[0053] In addition, it should be understood that although this specification is described in terms of implementation methods, not every implementation method contains only one independent technical solution. This narrative method of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment can also be appropriately combined to form other implementations that can be understood by those skilled in the art.

Claims

1. A thrombin solution virus inactivation device, comprising a pump body (1) and a frame (2), characterized in that: The input end of the pump body (1) is connected to a liquid storage device (3) for storing thrombin solution through a liquid inlet pipe (11), and a liquid outlet pipe (12) is installed at the output end of the pump body (1). A protective shell (4) is installed in the middle position of the frame (2), and a light-transmitting cylinder (6) for placing thrombin solution is provided in the protective shell (4). A plurality of semicircular protrusions (62) with outer concave and inner convex are staggered on the inner wall of the light-transmitting cylinder (6). A secondary transmission wheel (51) is fixedly installed at one end of the light-transmitting cylinder (6). The liquid outlet pipe (12) passes through the secondary transmission gear and extends to the inside of the light-transmitting cylinder (6). A plurality of annularly distributed ultraviolet lamps (41) are provided between the light-transmitting cylinder (6) and the protective shell (4). A driving device (51) is installed on the top of the frame (2). A motor (5), a main transmission wheel (52) corresponding to the auxiliary transmission wheel (51) is fixedly connected to the output end of the driving motor (5), and the main transmission wheel (52) and the auxiliary transmission wheel (51) are connected to each other through a transmission belt (53). The protective shell (4) is provided with a switch window (42), and a self-sealing joint (61) corresponding to the light-opening window is installed on the side wall of the light-transmitting cylinder (6). The self-sealing joint (61) can be inserted into a sampler (9) to extract thrombin solution from the inside of the light-transmitting cylinder (6) to detect the virus inactivation effect. The other end of the light-transmitting cylinder (6) is provided with a second liquid outlet pipe (71), and the other end of the second liquid outlet pipe (71) is connected to a second pump body (7), and the thrombin solution after virus inactivation is extracted through the second pump body (7); A rotating bearing 1 (63) is fixedly mounted on the outer end of the auxiliary transmission gear, and the inner ring of the rotating bearing 1 (63) is sealed and clamped with the liquid outlet pipe 1 (12). A rotating bearing 2 (64) is fixedly mounted on the liquid outlet end of the light-transmitting cylinder (6), and the inner ring of the rotating bearing 2 (64) is sealed and clamped with the liquid outlet pipe 2 (71), so as to ensure that the liquid outlet pipe 1 (12) and the liquid outlet pipe 2 (71) will not rotate together with the light-transmitting cylinder (6). The inner rings of the first rotary bearing (63) and the second rotary bearing (64) are both provided with a T-slot (631), a sealing ring (632) is placed in the T-slot (631), and the first liquid outlet pipe (12) and the second liquid outlet pipe (71) are both provided with an inner groove (121), and the other end of the sealing ring (632) is stuck in the inner groove (121) to form a sealing structure; The outer cover of the second rotating bearing (64) is provided with a fixed bearing (65), and the lower end of the protective shell (4) is provided with a support platform (44) for installing the fixed bearing (65) for rotatably supporting the other end of the light-transmitting tube (6).

2. A thrombin solution virus inactivation device according to claim 1, characterized in that: The liquid outlet pipe 1 (12) is provided with an electronic metering valve 1 (124), and the liquid outlet pipe 2 (71) is provided with an electronic metering valve 2 (711), which are respectively used to detect and control the inlet and outlet volumes of the thrombin solution.

3. A thrombin solution virus inactivation device according to claim 1, characterized in that: Sealing pads (66) are placed between the first rotating bearing (63) and the auxiliary transmission wheel (51), between the auxiliary transmission wheel (51) and the light-transmitting cylinder (6), and between the second rotating bearing (64) and the light-transmitting cylinder (6) to ensure the sealing effect of the device and ensure that the solution does not leak out.

4. A thrombin solution virus inactivation device according to claim 1, characterized in that: The sampler (9) includes a top cover (91), the lower end of the top cover (91) is rotatably connected to a detection cup (92), one side of the top cover (91) is provided with a sampling needle (93) connected to the detection cup (92), and the other end of the top cover (91) is provided with a micro-diaphragm liquid pump (94) corresponding to the sampling needle (93), and the thrombin solution is pumped from the sampling needle (93) to the sampling cup through the micro-diaphragm liquid pump (94).

5. A thrombin solution virus inactivation device according to claim 4, characterized in that: A manual valve (95) is provided between the sampling needle (93) and the top cover (91).

6. A thrombin solution virus inactivation device according to claim 1, characterized in that: The lower end of the protective shell (4) is provided with a drawer cabinet (43) capable of receiving ultraviolet light irradiation, and the sampler (9) after detection is placed in the drawer cabinet (43) to be sterilized and disinfected by ultraviolet light.

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