A composition with red fading efficacy and its use

Abstract

The application discloses a composition with red fading effect and application thereof, and the composition comprises the following components in percentage by mass: 90-99% of a fat-soluble solvent, and 1-10% of a sargent pea extract; wherein the fat-soluble solvent is at least one of glycol, caprylic acid / capric acid triglyceride, sunflower seed oil, macadamia nut oil, white pool flower seed oil, silicone oil, squalane, ethylhexyl palmitate, diisostearyl malate, polyglyceryl-2 triisostearate, camelina sativa seed oil, octyldodecanol, and cocoyl caprylate / caprate. The sargent pea extract is mixed with the fat-soluble solvent, and the prepared composition has very significant red fading effect.

Description

TECHNICAL FIELD

[0001] The present application relates to the cosmetic technology field, in particular to a composition with redness fading effect and application thereof. BACKGROUND

[0002] In recent years, sensitive skin causes skin problems such as skin burning, itching, erythema, and skin barrier damage, which have attracted increasing attention. These skin discomfort symptoms are generally induced by endogenous or exogenous factors, and the most prominent performance is redness and burning, which is closely related to the mechanism of vascular hyperresponsiveness. Among them, the red blood vessels caused by facial capillary dilation not only seriously affect the beauty of the patients, but also cause a great burden on the psychology of the patients. With the continuous improvement of people's living standards with the development of society, the quality and performance of cosmetics are also increasingly demanding. People hope to have a series of functional cosmetics that are harmless to human health and have beauty and health care effects.

[0003] Using Chinese herbal medicine extract as an additive of beauty and skin care cosmetics has the characteristics of stable, long-lasting drug effect, mild effect on skin, small irritation, high safety, and significant effect. At present, the liposoluble cosmetic raw materials with redness fading effect on the market are mainly anti-inflammatory models. Such raw materials not only have a large amount of addition, but also have a slow effect, and cannot quickly solve the problem of skin redness. Water-soluble and alcohol-soluble cosmetic raw materials are difficult to be compatible with essential oil, makeup remover oil, and color cosmetics.

[0004] Threeleaf kinrest is sweet and pungent in taste, and cold in nature. According to the record in Tang Bencao, it is used for treating edema, foot disease, promoting urination, reducing sputum, removing accumulation, and treating boils and swelling. It has the effects of diuresis, swelling reduction, heat clearing, and detoxification, and can be used for treating edema, difficulty in urination, stranguria, and pain. Threeleaf kinrest contains various chemical components, mainly lignans, flavonoids, volatile oils, alkaloids, polysaccharides, polyphenols, and liposoluble terpenes. SUMMARY

[0005] In view of the deficiencies of the prior art, the purpose of the present application is to develop a cosmetic raw material that can be compatible with essential oil, makeup remover oil, and color cosmetics, and can quickly and effectively improve skin redness and has skin barrier repair effect. Specifically, the purpose of the present application is to provide a composition with redness fading effect and application thereof. The present application uses liposoluble threeleaf kinrest extract, and dissolves it in a specific liposoluble solvent to obtain a composition with significant redness fading effect.

[0006] The purpose of the present application is achieved by the following technical scheme:

[0007] In the first aspect, the present application provides a composition with redness fading effect, which comprises the following components in mass percentage: liposoluble solvent 90-99%, threeleaf kinrest extract 1-10%.

[0008] The liposoluble solvent is at least one of the following: hexylene glycol, caprylic / capric triglyceride, sunflower seed oil, macadamia oil, meadowfoam seed oil, silicone oil, squalane, ethylhexyl palmitate, diisostearyl malate, polyglyceryl-2 triisostearate, camelina sativa seed oil, octyldodecanol, coco-caprylate / caprate.

[0009] As a preferred solution, the composition comprises the following mass percentage of each component: liposoluble solvent 90-97%, Saururus chinensis extract 3-10%. More preferably, the composition comprises the following mass percentage of each component: liposoluble solvent 90-95%, Saururus chinensis extract 3-5%.

[0010] As a preferred solution, the liposoluble solvent is at least one of the following: hexylene glycol, caprylic / capric triglyceride, sunflower seed oil, macadamia oil, meadowfoam seed oil, ethylhexyl palmitate, diisostearyl malate, polyglyceryl-2 triisostearate, camelina sativa seed oil, octyldodecanol. In the inventor's previous experimental research, it was found that the type of liposoluble solvent used has a great influence on the solubility and stability of the prepared composition, thereby affecting the red fading effect. For example, when silicone oil, squalane, or coco-caprylate / caprate is used as the liposoluble solvent, the solubility and stability of the prepared composition are poor.

[0011] As a further preferred solution, the liposoluble solvent is at least one of the following: caprylic / capric triglyceride, macadamia oil, octyldodecanol, which produces a composition with the best red fading effect.

[0012] As a preferred solution, the Saururus chinensis extract is a liposoluble Saururus chinensis extract.

[0013] As a preferred solution, the Saururus chinensis extract is prepared by the following method:

[0014] The Saururus chinensis raw material is extracted with alcohol, then filtered, and then adsorbed with resin and desorbed with alcohol, and then concentrated and dried to obtain the Saururus chinensis extract.

[0015] As a preferred solution, the alcohol is at least one of the following: ethanol, propanol, butanol, glycerol, butanediol.

[0016] As a preferred solution, the resin is a macroporous resin.

[0017] As a preferred solution, the method further comprises a decolorization step after elution with alcohol.

[0018] As a preferred solution, the method for preparing the Saururus chinensis extract comprises the following steps:

[0019] A1, extraction: cut the Sargentodoxa cappillipes raw material into segments, and then reflux extract the segments with ethanol with a volume fraction of 60-70%;

[0020] A2, enrichment: filter the extract obtained in step A1, and then adsorb the obtained filtrate a on a macroporous resin, and then desorb the macroporous resin with ethanol with a volume fraction of 80-95%, collect the desorption liquid, and then concentrate and dry the desorption liquid to obtain the Sargentodoxa cappillipes extract.

[0021] As a preferred solution, in step A1, the reflux extraction temperature is 80-90 ℃, the extraction times is 2-3 times, and the extraction time is 1.0-2.0 h each time.

[0022] As a preferred solution, in step A1, the ethanol is used in a dosage of 6-12 Bv.

[0023] As a preferred solution, in step A2, the macroporous resin is selected from at least one of D101, D101C, LX-100B, LX-T28, LX-T81, AB-8, and DM130.

[0024] As a preferred solution, in step A2, the volume-to-mass ratio of the macroporous resin to the Sargentodoxa cappillipes raw material is 0.5-2 (ml):1 (g), and the flow rate of the filtrate a is 0.5-3 Bv / h.

[0025] As a preferred solution, in step A2, the ethanol with a volume fraction of 80-95% is used in a dosage of 1-6 times the volume of the macroporous resin, and the flow rate is 0.5-3 Bv / h.

[0026] As a further preferred solution, in step A2, the ethanol used for desorption is ethanol with a volume fraction of 90-95%, and most preferably, the ethanol is ethanol with a volume fraction of 90%.

[0027] As a preferred solution, in step A2, the vacuum degree used for concentration and drying is 0.01-0.1 Mpa, and the temperature is 50-70 ℃.

[0028] In the previous experimental research of the inventors, it was found that the Sargentodoxa cappillipes extract obtained by using the foregoing extraction and enrichment steps can further improve the red fading effect of the composition. In step A2, when ethanol with a volume fraction of 80-95% is used for desorption, and the dosage of the ethanol is 1-6 times the volume of the macroporous resin, the red fading effect of the Sargentodoxa cappillipes extract obtained after being used in the composition is better. If ethanol with a volume fraction lower than 80% is used for desorption, or the dosage of the 80% ethanol is too low, the red fading effect of the corresponding composition will decrease to different degrees.

[0029] As a further preferred solution, to remove the pigment in the extract of Saururus chinensis, lighten the color of the extract of Saururus chinensis, and thus enable the prepared composition to be practically applied to a cosmetic product, in step A2, the desorbed solution collected is further subjected to a decoloring step before being concentrated and dried;

[0030] The decoloring step specifically comprises: first decoloring the desorbed solution with activated carbon and then filtering, and then decoloring the obtained filtered solution b with anion macroporous resin, collecting the decolorized solution and adjusting the pH to 6.5-7.1.

[0031] As a preferred solution, in the decoloring step, the activated carbon is coconut shell activated carbon with a mesh size of 200-300 mesh; and the amount of activated carbon used is 0.1-1% of the mass of the Saururus chinensis raw material. The use of activated carbon can remove chlorophyll and other impurities in the desorbed solution, thereby improving the stability of the Saururus chinensis extract and making the color lighter.

[0032] As a preferred solution, in the decoloring step, the temperature for decoloring with activated carbon is 15-60°C, and the stirring time is 20-60 min.

[0033] As a preferred solution, in the decoloring step, the filtering is performed using a 0.22-0.8 um membrane filter.

[0034] As a preferred solution, in the decoloring step, the anion macroporous resin used is a weak anion macroporous resin, specifically at least one selected from LX-T5, LX-94, D941, LXD-762, LXB-AS, and LXB-400. The use of anion macroporous resin can remove part of the red pigment impurities in the filtered solution b.

[0035] As a preferred solution, in the decoloring step, when decoloring with anion macroporous resin, the volume ratio of the filtered solution b to the anion macroporous resin is 10-30:1, and the flow rate of the filtered solution b is 0.5-3 Bv / h. If the amount of anion macroporous resin used is too high, it will lead to a decrease in the red fading effect of the finally prepared composition; and if the amount is too low, it will lead to a decrease in the decoloring effect. In the inventors' previous experimental research, it was found that only when the activated carbon decoloring is followed by anion macroporous resin decoloring, can the pigment impurities in the Saururus chinensis extract be effectively removed, so that the prepared composition can achieve the required color; and the red fading effect of the prepared composition is better. If only activated carbon decoloring or anion macroporous resin decoloring is performed, or the anion macroporous resin decoloring is performed first and then the activated carbon decoloring, the pigment removal effect of the Saururus chinensis extract will decrease to varying degrees, the color of the prepared composition will become darker to varying degrees, and the red fading effect of the composition will decrease to a certain extent.

[0036] In a second aspect, the present application provides a use of the aforementioned composition in the preparation of a cosmetic product having a redness-reducing effect.

[0037] As a preferred solution, the aforementioned composition is added in a mass percentage of 0.01-10% in the cosmetic product having a redness-reducing effect.

[0038] Compared with the prior art, the present application has the following beneficial effects:

[0039] 1) The present application has a very significant redness-reducing effect by mixing the extract of Saururus chinensis with a liposoluble solvent.

[0040] 2) The present application can further improve the redness-reducing effect of the composition by specifically selecting the mixing ratio of the extract of Saururus chinensis and the liposoluble solvent and the type of the liposoluble solvent.

[0041] 3) The present application can further improve the redness-reducing effect of the composition by further using the extract of Saururus chinensis prepared by a specific process. BRIEF DESCRIPTION OF DRAWINGS

[0042] Other features, objects and advantages of the present application will become more apparent from the following detailed description of non-limiting embodiments with reference to the attached drawings:

[0043] Figure 1 Photos of the desorption solution after enrichment, the filtered solution after decolorization by activated carbon and the elution solution after decolorization by anion resin in Example 2 of the present application;

[0044] Figure 2 Results of the redness-reducing effect of the product to be tested 0.5% Y1 on skin redness induced by capsaicin, histamine and methyl nicotinate;

[0045] Figure 3 Results of the redness-reducing effect of the product to be tested 0.5% Y2 on skin redness induced by capsaicin, histamine and methyl nicotinate;

[0046] Figure 4 Individual case display of the redness-reducing effect of the product to be tested 0.5% Y2 on skin redness induced by capsaicin, histamine and methyl nicotinate;

[0047] Figure 5 Results of the redness-reducing effect of the product to be tested 0.5% Y3 on skin redness induced by capsaicin, histamine and methyl nicotinate;

[0048] Figure 6 Results of the redness-reducing effect of the product to be tested 0.5% Y4 on skin redness induced by capsaicin, histamine and methyl nicotinate;

[0049] Figure 7The results of the relieving effect of 0.5% Y5 on the skin red induced by capsaicin, histamine and methyl nicotinate;

[0050] Figure 8 The results of the relieving effect of 0.5% Y6 on the skin red induced by capsaicin, histamine and methyl nicotinate;

[0051] Figure 9 The results of the relieving effect of 0.5% Y7 on the skin red induced by capsaicin, histamine and methyl nicotinate.

[0052] Figure 10 The results of the relieving effect of 0.5% Y8 on the skin red induced by capsaicin, histamine and methyl nicotinate;

[0053] Figure 11 The results of the relieving effect of 0.5% Y9 on the skin red induced by capsaicin, histamine and methyl nicotinate;

[0054] Figure 12 The results of the relieving effect of 0.5% Y10 on the skin red induced by capsaicin, histamine and methyl nicotinate;

[0055] Figure 13 The results of the relieving effect of 0.5% Y11 on the skin red induced by capsaicin, histamine and methyl nicotinate;

[0056] Figure 14 The results of the relieving effect of 0.5% Y12 on the skin red induced by capsaicin, histamine and methyl nicotinate.

[0057] Figure 15 The results of the relieving effect of 0.5% Y13 on the skin red induced by capsaicin, histamine and methyl nicotinate.

[0058] Figure 16 The results of the relieving effect of 0.5% Y14 on the skin red induced by capsaicin, histamine and methyl nicotinate.

[0059] Figure 17 The results of the relieving effect of 0.5% Y16 on the skin red induced by capsaicin, histamine and methyl nicotinate. DETAILED DESCRIPTION

[0060] The application will be described in greater detail below with reference to specific embodiments. The following examples will facilitate further understanding of the present application for those skilled in the art, but do not limit the present application in any form. It should be noted that, for those skilled in the art, a number of modifications and improvements can be made without departing from the concept of the present application. These all fall within the scope of the present application.

[0061] The raw materials of traditional Chinese medicine, reagents, etc. used in the experiment are provided by the company and / or purchased on the market. In the following examples, the percentage content of ethanol is the volume fraction. The content of sanguilutone in the used Sanguisorba officinalis raw material is 0.14%, the total lignan content is 0.3%, and the total terpene content is 0.36%. The determination method: sanguilutone adopts the 2020 edition of Chinese Pharmacopoeia, total terpene adopts the determination of total triterpenes in health food method, and total lignan adopts ultraviolet-visible spectrophotometry.

[0062] Example 1

[0063] The present embodiment provides a composition comprising 3.5% of Sanguisorba officinalis extract and 96.5% of caprylic / capric triglyceride (sample number Y1) by mass percentage. The specific preparation steps of the composition are as follows:

[0064] 1. Extraction: After cutting the Sanguisorba officinalis raw material (Sanguisorba officinalis stem and leaf) into segments, 500.0 g of the material is added with 5000 mL of 65% ethanol each time, and extracted at 80-90 ℃ for 1.5 h, twice. The extracted solution is cooled to room temperature, and then filtered.

[0065] 2. Enrichment: The filtered solution obtained in the extraction step is loaded onto a 500 mL D101 macroporous resin, and the loading flow rate is 2.0 Bv / h. After loading, 1500 mL of 80% ethanol is used for desorption, and the flow rate of 80% ethanol is 1.0 Bv / h. The desorbed solution is collected.

[0066] 3. Decolorization: 2.0 g of 200-300 mesh activated carbon of coconut shell type is added to the desorbed solution, and stirred at room temperature for 30 min for decolorization, and then filtered with a 0.45 um membrane. The obtained filtered solution is loaded onto LX-T5 anion resin (the volume ratio of the filtered solution to LX-T5 anion resin is 30:1) for decolorization, and the loading flow rate is 2.0 Bv / h. The eluent is collected and the pH is adjusted to 6.9-7.1 with citric acid. The solution photos before and after decolorization are shown in Figure 1

[0067] 4. Concentration and drying: The eluent obtained in the decolorization step is concentrated and dried in vacuum, the vacuum degree is 0.09 Mpa, the drying temperature is 60 ℃, and the drying time is 10 h. 4.0 g of extract (i.e. Sanguisorba officinalis extract) is obtained, the content of sanguilutone is 8.4%, the yield is 48.0%; the total lignan content is 17%, the yield is 45.3%; and the total terpene content is 20.0%, the yield is 44.4%.

[0068] 5. Lipid-soluble solvent dissolution: 2.0 g of extract is taken, and caprylic / capric triglyceride is added at a concentration of 3.5%. After dissolution and filtration, a composition with good stability is obtained.

[0069] ​Example 2

[0070] This example provides a composition comprising 3.5% of Saururus chinensis extract and 96.5% of caprylic / capric triglyceride (sample No. Y2) by mass percentage. The specific preparation steps of the composition are as follows:

[0071] 1. Extraction: After cutting the Saururus chinensis raw material (Saururus chinensis stem and leaf) into sections, 500.0 g of the material was added into 5000 mL of 70% ethanol, and reflux extraction was performed at 80-90 ℃ for 1.5 h, twice. The extraction liquid was cooled to room temperature, and the extraction liquid was filtered;

[0072] 2. Enrichment: The filtered liquid obtained in the extraction step was loaded onto a 400 mL D101 macroporous resin, and the loading flow rate was 2.5 Bv / h. After the loading was completed, 1500 mL of 90% ethanol was used for desorption, and the flow rate of the 90% ethanol was 1.0 Bv / h. The desorption liquid was collected;

[0073] 3. Decolorization: 2.0 g of 200-300 mesh coconut activated carbon was added to the desorption liquid, and the liquid was stirred at room temperature for 30 min for decolorization, and then 0.45 um membrane filtration was performed. The obtained filtered liquid was loaded onto LX-T5 anion resin (the volume ratio of the filtered liquid to the LX-T5 anion resin was 30:1) for decolorization, and the loading flow rate was 2.0 Bv / h. The eluent was collected and the pH was adjusted to 6.9-7.1 with citric acid;

[0074] 4. Concentration and drying: The eluent obtained in the decolorization step was concentrated and dried under vacuum, and the vacuum degree was 0.09 Mpa, the drying temperature was 60 ℃, and the drying time was 10 h. 4.5 g of extract (i.e., Saururus chinensis extract) was obtained, and the content of Saururus chinensis ketone was determined by HPLC to be 14%, and the yield was 90.0%. The total lignan content was 28%, and the yield was 84.0%. The total terpene content was 25.0%, and the yield was 62.5%.

[0075] 5. Lipid-soluble solvent dissolution: 1.0 g of the extract was taken, and caprylic / capric triglyceride was added at a concentration of 3.5%. After dissolution and filtration, a composition with good stability was obtained.

[0076] Example 3

[0077] This example provides a composition comprising 3.5% of Saururus chinensis extract and 96.5% of caprylic / capric triglyceride (sample No. Y3) by mass percentage. The specific preparation steps of the composition are as follows:

[0078] 1. Extraction: cut the raw material (Saururus chinensis stems and leaves) into pieces, add 500.0 g of the raw material, add 5000 mL of 70% ethanol each time, reflux extraction at 80-90 ℃ for 1.5 h, extract for 2 times, combine the extract, cool to room temperature, and filter the extract;

[0079] 2. Enrichment: load the filtered solution obtained in the extraction step onto a 400 mL D101 macroporous resin, the loading flow rate is 2.5 Bv / h; after loading is completed, desorb with 1500 mL of 95% ethanol, the flow rate of 95% ethanol is 1.0 Bv / h, and collect the desorption solution;

[0080] 3. Decolorization: add 2.0 g of 200-300 mesh activated carbon of coconut shell type to the desorption solution, stir at room temperature for 30 min for decolorization, and then filter with a 0.45 um membrane; load the obtained filtered solution onto LX-T5 anion resin (the volume ratio of the filtered solution to the LX-T5 anion resin is 30:1) for decolorization, the loading flow rate is 2.0 Bv / h, collect the eluate, and adjust the pH to 6.9-7.1 with citric acid;

[0081] 4. Concentration and drying: vacuum concentration and drying of the eluate obtained in the decolorization step, the vacuum degree is 0.09 Mpa, the drying temperature is 60 ℃, and the drying time is 10 h. 4.8 g of extract (i.e. Saururus chinensis extract) is obtained, the content of Saururus chinensis ketone is 10.2% as determined by HPLC, the yield is 69.9%; the total lignan content is 23%, the yield is 73.6%; and the total terpene content is 25.5%, the yield is 68.0%.

[0082] 5. Lipid-soluble solvent dissolution: take 1.0 g of the extract, add caprylic acid / capric acid triglyceride at a concentration of 3.5%, dissolve and filter to obtain a composition with good stability.

[0083] Example 4

[0084] This example provides a composition comprising 3.5% of Saururus chinensis extract and 96.5% of macadamia nut oil (sample number Y4) by mass percentage. The specific preparation steps of the composition are basically the same as those of Example 2, except that the caprylic acid / capric acid triglyceride in step 5 is replaced by macadamia nut oil.

[0085] Example 5

[0086] This example provides a composition comprising 3.5% of Saururus chinensis extract and 96.5% of octyldodecanol (sample number Y5) by mass percentage. The specific preparation steps of the composition are basically the same as those of Example 2, except that the caprylic acid / capric acid triglyceride in step 5 is replaced by octyldodecanol.

[0087] Example 6

[0088] This example provides a composition comprising 1% of Saururus chinensis extract and 99% of octyldodecanol by mass percentage (sample No. Y6). The specific preparation steps of the composition are the same as those of Example 1.

[0089] Example 7

[0090] This example provides a composition comprising 10% of Saururus chinensis extract and 90% of octyldodecanol by mass percentage (sample No. Y7). The specific preparation steps of the composition are the same as those of Example 1. In the composition prepared in this example, the solubility of the Saururus chinensis extract is greatly reduced, and the prepared composition has a dark color.

[0091] Example 8

[0092] This example provides a composition comprising 5% of Saururus chinensis extract and 95% of octyldodecanol by mass percentage (sample No. Y8). The specific preparation steps of the composition are the same as those of Example 1.

[0093] Example 9

[0094] This example provides a composition comprising 3.5% of Saururus chinensis extract and 96.5% of hexanediol by mass percentage (sample No. Y9). The specific preparation steps of the composition are basically the same as those of Example 2, except that the octanoic acid / decanoic acid triglyceride in step 5 is replaced by hexanediol.

[0095] Example 10

[0096] This example provides a composition comprising 3.5% of Saururus chinensis extract and 96.5% of squalane by mass percentage (sample No. Y10). The specific preparation steps of the composition are basically the same as those of Example 2, except that the octanoic acid / decanoic acid triglyceride in step 5 is replaced by squalane.

[0097] Example 11

[0098] This example provides a composition comprising 3.5% of Saururus chinensis extract and 96.5% of sunflower seed oil by mass percentage (sample No. Y11). The specific preparation steps of the composition are basically the same as those of Example 2, except that the octanoic acid / decanoic acid triglyceride in step 5 is replaced by sunflower seed oil.

[0099] Example 12

[0100] This example provides a composition comprising 3.5% of Saururus chinensis extract and 96.5% of polyglyceryl-2 triisostearate (sample No. Y12) by mass percentage. The specific preparation steps of the composition are basically the same as those of Example 2, except that the caprylic / capric triglyceride in step 5 is replaced by polyglyceryl-2 triisostearate.

[0101] Example 13

[0102] This example provides a composition comprising 3% of Saururus chinensis extract and 97% of caprylic / capric triglyceride (sample No. Y13) by mass percentage. The specific preparation steps of the composition are as follows:

[0103] 1. Extraction: After cutting the Saururus chinensis raw material (Saururus chinensis stem and leaf) into sections, 500.0 g of the material is added into 6000 mL of 60% ethanol, and reflux extraction is performed at 80-90 ℃ for 1 h. The extraction is performed for 3 times, and the extracted solution is cooled to room temperature. The extracted solution is filtered.

[0104] 2. Enrichment: The filtered solution obtained in the extraction step is loaded onto a 1000 mL LX-100B macroporous resin, and the loading flow rate is 1.0 Bv / h. After the loading is completed, 6000 mL of 80% ethanol is used for desorption, and the flow rate of the 80% ethanol is 3.0 Bv / h. The desorbed solution is collected.

[0105] 3. Decolorization: 1.0 g of 200-300 mesh coconut activated carbon is added into the desorbed solution, and the solution is stirred at 60 ℃ for 20 min for decolorization, and then filtered by using a 0.45 um membrane. The obtained filtered solution is loaded onto LX-T5 anion resin (the volume ratio of the filtered solution to the LX-T5 anion resin is 10:1) for decolorization, and the loading flow rate is 1.0 Bv / h. The eluent is collected and the pH is adjusted to 6.5-6.7 by using citric acid. The color of the obtained decolorized solution is basically the same as that of Example 1.

[0106] 4. Concentration and drying: The eluent obtained in the decolorization step is concentrated and dried by using vacuum, and the vacuum degree is 0.05 Mpa, the drying temperature is 50 ℃, and the drying time is 20 h. 3.2 g of extract (i.e. Saururus chinensis extract) is obtained.

[0107] 5. Lipid-soluble solvent dissolution: 2.0 g of the extract is taken, and caprylic / capric triglyceride is added at a concentration of 3%. After dissolution and filtration, a composition with good stability is obtained.

[0108] Example 14

[0109] This example provides a composition comprising 4% of Saururus chinensis extract and 96% of caprylic / capric triglyceride (sample No. Y14) by mass percentage. The specific preparation steps of the composition are as follows:

[0110] 1. Extraction: cut the Sargentodoxa cappillipes raw material (Sargentodoxa cappillipes stem and leaf) into pieces, and then put 500.0 g of the pieces into 3000 mL of 70% ethanol each time, and reflux extraction was performed at 80-90 ℃ for 2 h, and the extraction was performed twice. The extraction liquid was cooled to room temperature, and the extraction liquid was filtered.

[0111] 2. Enrichment: the filtered liquid obtained in the extraction step was loaded onto a 250 mL LX-100B macroporous resin, and the loading flow rate was 0.5 Bv / h. After the loading was completed, 250 mL of 90% ethanol was used for desorption, and the flow rate of the 90% ethanol was 0.5 Bv / h. The desorption liquid was collected.

[0112] 3. Decolorization: 5.0 g of 200-300 mesh activated carbon of coconut shell type was added to the desorption liquid, and the mixture was stirred at 20 ℃ for 30 min for decolorization, and then 0.45 um membrane filtration was performed. The obtained filtered liquid was loaded onto LX-T5 anion resin (the volume ratio of the filtered liquid to the LX-T5 anion resin was 30:1) for decolorization, and the loading flow rate was 3.0 Bv / h. The eluent was collected, and citric acid was used to adjust the pH to 6.7-6.9. The color of the obtained decolorized liquid was basically the same as that of Example 1.

[0113] 4. Concentration and drying: the eluent obtained in the decolorization step was concentrated and dried in vacuum, the vacuum degree was 0.05 Mpa, the drying temperature was 70 ℃, and the drying time was 5 h. 2.8 g of extract (i.e., Sargentodoxa cappillipes extract) was obtained.

[0114] 5. Lipid-soluble solvent dissolution: 2.0 g of the extract was taken, and caprylic triglyceride / capric triglyceride was added at a concentration of 4%. After dissolution and filtration, a composition with good stability was obtained.

[0115] Example 15

[0116] The present example provides a composition comprising 3.5% of Sargentodoxa cappillipes extract and 96.5% of caprylic triglyceride / capric triglyceride by mass percentage (sample No. Y15). The specific preparation steps of the composition are as follows:

[0117] 1. Extraction: cut the Sargentodoxa cappillipes raw material (Sargentodoxa cappillipes stem and leaf) into pieces, and then put 300.0 g of the pieces into 3000 mL of 50% ethanol each time, and reflux extraction was performed at 80-90 ℃ for 2 h, and the extraction was performed twice. The extraction liquid was cooled to room temperature, and the extraction liquid was filtered.

[0118] 2. Enrichment: the filtered liquid obtained in the extraction step was loaded onto a 300 mL D101 macroporous resin, and the loading flow rate was 2.0 Bv / h. After the loading was completed, 600 mL of 70% ethanol was used for desorption, and the flow rate of the 70% ethanol was 1.0 Bv / h. The desorption liquid was collected.

[0119] 3. Concentration and drying: The desorption solution obtained in the enrichment step was concentrated and dried under vacuum, with a vacuum degree of 0.05 MPa, a drying temperature of 70°C, and a drying time of 8 h. An extract (i.e., a Sargentodoxa extract) 0.5 g was obtained.

[0120] 4. Lipid-soluble solvent dissolution: 0.4 g of the extract was taken, and caprylic / capric triglyceride was added at a concentration of 3.5%. After dissolution and filtration, a composition was obtained. Since the decolorization treatment was not performed in this comparative example, the composition prepared had a darker color than that of Example 1, and was less stable, with a precipitate separating out after 1 day of storage.

[0121] Comparative Example 1

[0122] This comparative example provides a composition comprising 0.3% Sargentodoxa ketone and 99.7% caprylic / capric triglyceride by mass percentage (sample No. Y16). The specific preparation steps of the composition are as follows:

[0123] Specific steps: 20 mg of Sargentodoxa ketone standard was taken, and caprylic / capric triglyceride was added at a concentration of 0.3%. After dissolution and filtration, a composition was obtained.

[0124] Efficacy verification:

[0125] The compositions prepared in Examples 1-14 (sample Nos. Y1-Y14) and Comparative Example 1 (sample No. Y16) were used to prepare Sargentodoxa extract solution or Sargentodoxa ketone solution at a concentration of 0.5% for each test product. The preparation ratio of each test product is shown in Table 1 below. The test products prepared from the extracts of Examples 1-15 are denoted as 0.5% Y1-0.5% Y14, and the test product prepared from the composition of Comparative Example 1 is denoted as 0.5% Y16.

[0126] Table 1

[0127]

[0128] The preparation steps of each test product are as follows:

[0129] 1. A and B phases were heated to 80-85°C, respectively, and stirred uniformly.

[0130] 2. A phase was added to B phase, and homogenized for 3 mins.

[0131] 3. Continue stirring until about 40°C, and add C phase.

[0132] In addition, caprylic / capric triglyceride, macadamia nut oil, octyldodecanol, ethylene glycol, squalane, sunflower seed oil, and polyglyceryl-2 triisostearate were used to prepare solvent control products at a corresponding concentration of 0.5% using the above matrix raw materials.

[0133] Each product to be tested and each solvent control product was subjected to clinical redness removal testing. The clinical redness removal testing models included capsaicin stimulation model, histamine stimulation model, and methyl nicotinate stimulation model. Among them, capsaicin, histamine, and methyl nicotinate were purchased from the market, and the ethical committee of Shanghai Gaoke Co., Ltd. approved this study (approval numbers: JKC-2409-0051, JKC-2409-0052). The concentrations of capsaicin, histamine, and methyl nicotinate used were 200 μg / mL, 20 mg / mL, and 20 mM, respectively.

[0134] The specific test scheme is as follows:

[0135] ① After washing the inside of the arm, balance for 20 min, and use a marker pen to mark the test area of each group3 3 cm 2 , and each test area is at least 1 cm apart;

[0136] ② Use a skin color measurement instrument (Skin Color Catch, brand: Delfin) to test the skin basic a value (i.e., a value 刺激前 ), after applying 30 μL of stimulant for 15 min, test the probe a value (i.e., a value 刺激后 ), and take a photo with Vplus, which is recorded as repair 0 min.

[0137] ③ Then, the sample group is applied with 25 μL of each test sample or solvent control sample; the stimulant group is not applied with any sample.

[0138] After applying each test sample or solvent control sample for 30 min, the sample group and the stimulant group are again tested for probe a value (i.e., a value 修护后 ), and take a photo with Vplus, which is recorded as repair 30 min.

[0139] The specific data analysis method is as follows:

[0140] The Δa value of each sample group and the stimulant group is calculated using the following formula:

[0141] Δa value = a value 修护后 - a value 刺激前

[0142] Compared with the stimulant group, the Δa The rate of change of value is calculated using the following formula:

[0143] Δa Rate of change of value (%) = (Δa) value 样品组 / Δa value 刺激物组 -1) 100%

[0144] Paired T-test, α=0.05, compared with the matrix group, represent P <0.001, represent P <0.01, represent P <0.05, ns represents P >0.05.

[0145] After stimulation with various stimuli, Δa for each sample group The results of the value change rate test are shown in Table 2. Δa for each solvent control group... The rate of change of values ​​was less than 5%.

[0146] Table 2

[0147]

[0148] The results of the alleviating effect of the tested product 0.5% Y1 on skin redness induced by capsaicin, histamine, and methyl nicotinic acid are as follows: Figure 2 As shown. Compared to the irritant group containing capsaicin, histamine, and methyl nicotinic acid, 0.5% Y1 showed Δa The rate of change of the values ​​were -44.69%, -40.42%, and -30.04%, respectively.

[0149] The results of the alleviating effect of the tested product 0.5% Y2 on skin redness induced by capsaicin, histamine, and methyl nicotinic acid are as follows: Figure 3 and Figure 4 As shown. Compared to the irritant group containing capsaicin, histamine, and methyl nicotinic acid, 0.5% Y2 showed Δa The rate of change of the values ​​were -57.41%, -72.59%, and -48.81%, respectively.

[0150] The results of the alleviating effect of the tested product 0.5% Y3 on skin redness induced by capsaicin, histamine, and methyl nicotinic acid are as follows: Figure 5 As shown. Compared to the irritant group containing capsaicin, histamine, and methyl nicotinic acid, 0.5% Y3 showed Δa The rate of change of the values ​​were -61.37%, -67.04%, and -48.21%, respectively.

[0151] The results of the remission effect of the test product 0.5% Y4 on the skin red induced by capsaicin, histamine and methyl nicotinate are shown in Table 6. Figure 6 Compared with the irritant groups of capsaicin, histamine and methyl nicotinate, the change rate of Δa* of 0.5% Y4 was -61.90%, -65.81% and -47.47%, respectively.

[0152] The results of the remission effect of the test product 0.5% Y5 on the skin red induced by capsaicin, histamine and methyl nicotinate are shown in Table 7. Figure 7 Compared with the irritant groups of capsaicin, histamine and methyl nicotinate, the change rate of Δa* of 0.5% Y5 was -51.19%, -53.33% and -43.65%, respectively.

[0153] The results of the remission effect of the test product 0.5% Y6 on the skin red induced by capsaicin, histamine and methyl nicotinate are shown in Table 8. Figure 8 Compared with the irritant groups of capsaicin, histamine and methyl nicotinate, the change rate of Δa* of 0.5% Y6 was -17.45%, -10.82% and -10.91%, respectively.

[0154] The results of the remission effect of the test product 0.5% Y7 on the skin red induced by capsaicin, histamine and methyl nicotinate are shown in Table 9. Figure 9 Compared with the irritant groups of capsaicin, histamine and methyl nicotinate, the change rate of Δa* of 0.5% Y7 was -40.92%, -22.77% and -24.26%, respectively.

[0155] The results of the remission effect of the test product 0.5% Y8 on the skin red induced by capsaicin, histamine and methyl nicotinate are shown in Table 10. Figure 10 Compared with the irritant groups of capsaicin, histamine and methyl nicotinate, the change rate of Δa* of 0.5% Y8 was -56.68%, -50.81% and -49.74%, respectively.

[0156] The results of the remission effect of the test product 0.5% Y9 on the skin red induced by capsaicin, histamine and methyl nicotinate are shown in Table 11. Figure 11 Compared with the irritant groups of capsaicin, histamine and methyl nicotinate, the change rate of Δa* of 0.5% Y9 was -46.74%, -42.89% and -24.41%, respectively.

[0157] The results of the remission effect of the test product 0.5% Y10 on the skin red induced by capsaicin, histamine and methyl nicotinate are shown in Table 12. Figure 12 Compared with the irritant groups of capsaicin, histamine and methyl nicotinate, the change rate of Δa* of 0.5% Y10 was -45.74%, -42.89% and -24.41%, respectively. ​​​​​​The value change rates were -24.19%, -17.21%, and -6.25%, respectively.

[0158] The results of the relieving effect of the tested product 0.5% Y11 on the skin red induced by capsaicin, histamine, and methyl nicotinate are shown in the table. Figure 13 Compared with the stimulant groups of capsaicin, histamine, and methyl nicotinate, the Δa values of 0.5% Y11 were -65.72%, -54.17%, and -43.01%, respectively.

[0159] The results of the relieving effect of the tested product 0.5% Y12 on the skin red induced by capsaicin, histamine, and methyl nicotinate are shown in the table. Figure 14 Compared with the stimulant groups of capsaicin, histamine, and methyl nicotinate, the Δa values of 0.5% Y12 were -57.82%, -54.94%, and -49.87%, respectively.

[0160] The results of the relieving effect of the tested product 0.5% Y13 on the skin red induced by capsaicin, histamine, and methyl nicotinate are shown in the table. Figure 15 Compared with the stimulant groups of capsaicin, histamine, and methyl nicotinate, the Δa values of 0.5% Y13 were -55.13%, -44.41%, and -35.94%, respectively.

[0161] The results of the relieving effect of the tested product 0.5% Y14 on the skin red induced by capsaicin, histamine, and methyl nicotinate are shown in the table. Figure 16 Compared with the stimulant groups of capsaicin, histamine, and methyl nicotinate, the Δa values of 0.5% Y14 were -53.68%, -47.25%, and -42.19%, respectively.

[0162] The results of the relieving effect of the tested product 0.5% Y16 on the skin red induced by capsaicin, histamine, and methyl nicotinate are shown in the table. Figure 17 Compared with the stimulant groups of capsaicin, histamine, and methyl nicotinate, the Δa values of 0.5% Y16 were -26.89%, -14.08%, and -5.21%, respectively.

[0163] The application has many specific application approaches, and the above description is only a preferred embodiment of the application. It should be noted that the above examples are only used to illustrate the application, and are not used to limit the protection scope of the application. For ordinary skilled persons in the art, some improvements can be made without departing from the principles of the application, and these improvements should also be considered as the protection scope of the application.​​​​​

Claims

1. A composition having redness-reducing efficacy, characterized in that, Comprise the following quality percentage content of each component: fat-soluble solvent 95~97%, Saururus chinensis extract 3~5%; The fat-soluble solvent is at least one of glycol, caprylic / capric triglyceride, sunflower seed oil, macadamia oil, polyglyceryl-2 triisostearate, and octyldodecanol; The Saururus chinensis extract is prepared by the following method: The Saururus chinensis raw material is extracted with alcohol, then filtered, and then adsorbed with resin and desorbed with alcohol, and then concentrated and dried to obtain the Saururus chinensis extract; The specific steps of adsorbing with resin and desorbing with alcohol are as follows: the filtered filtrate a is adsorbed on a macroporous resin, and then desorbed with ethanol with a volume fraction of 80~95%, and the desorption liquid is collected; The collected desorption liquid further comprises a step of decolorization before being concentrated and dried. The step of decolorization is specifically as follows: the desorption liquid is first decolorized with activated carbon and then filtered, and then the obtained filtrate b is decolorized with an anion macroporous resin, and the decolorized liquid is collected and adjusted to a pH of 6.5~7.

1.

2. The composition with redness reduction efficacy according to claim 1, characterized in that, The Saururus chinensis extract is fat-soluble.

3. The composition with redness reduction efficacy according to claim 1, characterized in that, The alcohol used for extraction is at least one of ethanol, propanol, butanol, glycerol, and butanediol.

4. The composition with redness fading efficacy according to claim 1 or 3, characterized in that, In the preparation method of the Saururus chinensis extract, the step of extraction is as follows: The Saururus chinensis raw material is cut into sections, and then extracted with ethanol with a volume fraction of 60~70% by reflux.

5. Use of the composition according to any one of claims 1-4 in the preparation of a cosmetic product having a redness-reducing effect, the composition being added in an amount of 0.01~10%.

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