A preparation system and method of suture with development function and suture

Abstract

The present invention belongs to the field of medical equipment manufacturing technology, and more specifically, relates to a preparation system and method for sutures with developing functions and sutures thereof. The preparation system includes a loading module, a multi-channel module, and a curing module connected in sequence by connecting pipes, and a breaking strength detection module, a cleaning tank, an air shower chamber, a weaving module, and an X-ray detection module that are sequentially transported by a number of rollers to transport the core wires; the multi-channel module includes a left channel, a right channel, and a middle channel; the left channel and the right channel are symmetrically distributed on both sides of the middle channel and intersect at the middle channel; the discharge port of the loading module is divided into two branches, which are respectively connected to the feed ports of the left channel and the right channel. The system of the present invention can achieve equidistant distribution of the developer, and can produce developer sutures of different specifications. The developer does not directly contact the human tissue fluid and has the ability to monitor the displacement of the suture for a long time.

Description

Technical Field

[0001] The invention belongs to the technical field of medical device manufacturing, and more specifically relates to a preparation system and method of a suture with a developing function and the suture. Background Art

[0002] In surgery, to meet the requirements of subsequent treatment and operation, the developing suture can be placed in a specific area as a marker. The surgical gauze is attached with a developing suture to avoid leaving the used gauze in the patient's body. In orthopedic surgery, the torn soft tissue is anchored to the bone through the anchor with the developing suture. The developing liquid is distributed along the axial developing suture to monitor whether the soft tissue is anchored in place and whether the anchor is loose.

[0003] However, there are many problems with existing developing sutures. First, the bonding force between the suture base material and the developer is weak. When the suture is implanted in the body and contacts tissues and body fluids, the developer will diffuse rapidly, and the suture will quickly lose its developing ability, or the surface developing coating will fall off due to friction, making it difficult to achieve mid- and long-term monitoring and positioning after surgery. Second, the developer only exists on the surface of the suture. Excessive local developer concentration may enhance toxic side effects and affect the biocompatibility of the suture. When the developer concentration is low, the developing ability will be affected. Third, when multiple sutures (two or more sutures) are used in surgery, doctors cannot distinguish them under X-rays. Fourth, the process of coating the developing coating on the suture is complicated, and it is impossible to ensure that the developing coating is distributed at equal distances, so it is impossible to monitor the displacement of the suture. Fifth, the preparation of developing sutures has not yet achieved full-process automated production, and the production efficiency is low.

[0004] Therefore, how to provide a system and method for preparing a suture with a developing function and the suture thereof is an issue that those skilled in the art urgently need to solve. Summary of the invention

[0005] In order to overcome the shortcomings and deficiencies in the prior art, the present invention provides a system and method for preparing a suture with a developing function and the suture.

[0006] In order to achieve the above object, the present invention adopts the following technical solution:

[0007] A suture preparation system with a developing function, comprising a feeding module, a multi-channel module, a curing module connected in sequence through a connecting pipe, and a breaking strength detection module, a cleaning tank, an air shower chamber, a braiding module, and an X-ray detection module into which a core wire is sequentially conveyed by a plurality of rollers;

[0008] The multi-channel module includes a left channel, a right channel and a middle channel; the left channel and the right channel are symmetrically distributed on both sides of the middle channel and intersect at the middle channel;

[0009] The discharge port of the feeding module is divided into two branches, which are respectively connected to the feed ports of the left channel and the right channel;

[0010] The feeding module further comprises an injection submodule, and the discharge port of the injection submodule is connected to the feed port of the middle channel.

[0011] Preferably, the multi-channel module has a length of 30 mm-120 mm, a width of 10-25 mm, and a height of 5-20 mm; and a cross-sectional diameter of each channel ranges from 100 um to 600 um.

[0012] The beneficial effects of the above technical solution are: different multi-channel modules can be selected according to the thickness of the core wire to be processed, and different modules have different channel cross-sectional areas. The modular design can achieve fast switching, small batch production of multiple specifications, and fast troubleshooting.

[0013] Preferably, the breaking strength detection module comprises a movable roller, and the core wire is tightened by controlling the position of the movable roller relative to the core wire so as to apply a predetermined tension thereto.

[0014] Preferably, it also includes a control panel and a device housing;

[0015] The control panel is interconnected with other modules, and the control panel is used to control the rotation speed of each module and the roller, and at the same time, feedback signals from each module are received;

[0016] The plurality of rollers are fixed on the device housing.

[0017] Preferably, the control panel includes a touch screen display, which displays status information and feedback signal information of each module;

[0018] The touch screen can be used to control the heating temperature of the feeding module, the injection parameters of the injection submodule, the switch of the UV lamp in the curing module and the irradiation time, the position parameters of the movable roller in the breaking strength detection module and the monitoring of the core wire tension, the depth of the cleaning liquid injected into the cleaning tank, the switch of the air shower chamber and the air shower time, the weaving parameters of the weaving module, the switch of the X-ray light source in the X-ray detection module and the monitoring of the development effect of the suture line in the X-ray image, and the rotation speed of the roller.

[0019] The present invention also provides a method for preparing a suture with a developing function, using the above-mentioned preparation system, comprising the following steps:

[0020] (1) Loading: Add solid resin powder into the loading module, turn on the heating switch on the control panel to melt the powder into liquid resin, or turn off the heating switch and directly add liquid resin into the loading module, and add developer into the injection submodule at the same time;

[0021] (2) Polymerization: In the multi-channel module, the liquid resin wraps the developer so that the developer is in the middle horizontal position and is evenly distributed axially in the liquid resin. The axial spacing of the developer in the liquid resin is controlled by the injection speed of the developer.

[0022] (3) Curing: The liquid resin wrapped in the developer is introduced into the curing module, and the liquid resin is cured under ultraviolet light to obtain a core wire;

[0023] (4) Breaking strength test: The core wire obtained after the liquid resin is cured is introduced into the breaking strength test module. The tension between the core wires is adjusted by changing the position of the moving roller through the control panel to test the quality of the core wire.

[0024] (5) Cleaning and drying: After the breaking strength test, the core wire enters the cleaning tank for cleaning, and then enters the air shower chamber for drying;

[0025] (6) Shell wire weaving: The cleaned and dried core wire is introduced into the weaving module, and the shell wire is weaved outside the core wire to obtain the developed suture wire;

[0026] (7) Development effect detection: Guide the development suture line into the X-ray detection module, turn on the X-ray light source switch on the control panel, and observe the development effect on the display screen. When the expected effect is achieved, continuous production can be carried out.

[0027] Preferably, the solid resin is selected from one of polylactic acid and polyvinyl acetate; the liquid resin is selected from one of epoxy resin and polyvinyl acetate; the developer is selected from one of iohexol, iohexol, diatrizoate and gadolinium developer.

[0028] Preferably, the injection submodule is controlled to inject the developer into the middle channel at the same interval, each interval is 0.1-2.5s, and the flow rate is 0.3-1.2ul / min.

[0029] The beneficial effects of the above technical solution are: the injection submodule is controlled so that the developer is wrapped in the solid resin, thereby achieving uniform distribution of the developer in the developed sutures, and by adjusting the injection interval time and flow rate, sutures of different developed lengths can be generated. Therefore, in surgeries using multiple sutures, each suture can be distinguished and monitored by the development of the sutures, such as whether the sutures are broken or displaced.

[0030] Preferably, the irradiation time of the ultraviolet light in the curing module is greater than 35 seconds.

[0031] Preferably, the shell wire is made of absorbable material or non-absorbable material.

[0032] Preferably, the absorbable material is selected from one of polyvinyl alcohol fibers, polyglycolide fibers, poly(propylene glycolide) fibers, polydioxanone fibers, collagen fibers, polyglycolic acid fibers, and polyglycol carbonate fibers.

[0033] Preferably, the non-absorbable material is selected from one of ultra-high molecular weight polyethylene fiber, polyester fiber, polypropylene fiber and nylon fiber.

[0034] Preferably, the braiding module can adjust the number of braided strands according to the specifications of the suture.

[0035] The present invention also provides a suture thread prepared according to the method, wherein the suture thread comprises a core thread and a shell thread, wherein the core thread is composed of a developer and a resin, and the developer in the core thread is distributed equidistantly along the axial direction.

[0036] It can be seen from the above technical solutions that, compared with the prior art, the present invention provides a system and method for preparing a suture with a developing function and a suture thereof, which have the following beneficial effects:

[0037] 1. The system of the present invention can achieve equidistant distribution of developer and can produce sutures with different development shapes. The developer does not come into direct contact with human tissue fluid and has the ability to monitor the displacement of sutures for a long time. Compared with the developed sutures using surface coating technology, the sutures of the present invention will not cause the coating to fall off due to friction and the development will not fail. One system can complete the production and quality inspection from raw materials to finished products without circulation, with high production efficiency and reduced contamination of sutures.

[0038] 2. In surgeries with multiple sutures, the sutures can be distinguished by the different intervals of the developer, so as to determine the condition of each suture, including whether the suture knot is loose, whether the suture slips, etc. In conjunction with the anchor, the displacement of the anchor can be determined by monitoring the condition of the suture.

[0039] 3. By selecting shell threads of different materials, the present invention can be used to make absorbable or non-absorbable developing suture threads, and has a wide range of applications. When the shell thread is made of absorbable material, the degradation of the absorbable suture thread can be monitored, and the core thread can eventually be decomposed and absorbed by the human body and excreted from the body. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying creative work.

[0041] Figure 1is a schematic diagram of a system for preparing sutures of the present invention;

[0042] Figure 2 is a schematic diagram of a suture of the present invention;

[0043] Among them: 1- solid resin powder, 2- feeding module, 3- control panel, 4- injection submodule, 5- developer, 6- multi-channel module, 7- curing module, 8- breaking strength detection module, 9- left channel, 10- middle channel, 11- right channel, 12- movable roller, 13- cleaning tank, 14- air shower chamber, 15- weaving module, 16- X-ray detection module, 17- core wire, 18- shell wire. DETAILED DESCRIPTION

[0044] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0045] The embodiment of the present invention provides a suture preparation system with a developing function, comprising a feeding module 2, a multi-channel module 6, a curing module 7 connected in sequence by connecting pipes, and a breaking strength detection module 8, a cleaning tank 13, an air shower chamber 14, a braiding module 15, and an X-ray detection module 16 into which a core wire is sequentially conveyed by a plurality of rollers;

[0046] The multi-channel module 6 includes a left channel 9, a right channel 11 and a middle channel 10; the left channel 9 and the right channel 11 are symmetrically distributed on both sides of the middle channel 10 and intersect at the middle channel 10;

[0047] The discharge port of the feeding module 2 is divided into two branches, which are respectively connected to the feed ports of the left channel 9 and the right channel 11;

[0048] The feeding module 2 further includes an injection submodule 4 , and a discharge port of the injection submodule 4 is connected to a feed port of the middle channel 10 .

[0049] The multi-channel module 6 has a length of 30 mm to 120 mm, a width of 10 mm to 25 mm, and a height of 5 mm to 20 mm; and a cross-sectional diameter of each channel ranges from 100 um to 600 um.

[0050] The breaking strength detection module 8 includes a movable roller 12. By controlling the position of the movable roller 12 relative to the core wire 17, the core wire 17 is tightened to apply a predetermined tension thereto.

[0051] The irradiation time of the ultraviolet light in the curing module 7 is greater than 35 seconds.

[0052] Also includes a control panel 3 and a device housing;

[0053] The control panel 3 is interconnected with other modules, and the control panel 3 is used to control the rotation speed of each module and the roller, and receive feedback signals from each module;

[0054] The plurality of rollers are fixed on the device housing.

[0055] The control panel 3 includes a touch screen, which displays the status information and feedback signal information of each module;

[0056] The touch screen can control the heating temperature of the feeding module 2, the injection parameters of the injection submodule 4, the switch of the ultraviolet lamp in the curing module 7 and the irradiation time, the position parameters of the movable roller 12 in the breaking strength detection module 8 and the tension of the monitoring core wire 17, the depth of the cleaning liquid injected into the cleaning tank 13, the switch of the air shower chamber 14 and the air shower time, the weaving parameters of the weaving module 15, the switch of the X-ray light source in the X-ray detection module 16 and the monitoring of the development effect of the suture line in the X-ray image, and the rotation speed of the roller.

[0057] Example 1

[0058] A method for preparing a suture with a developing function comprises the following steps:

[0059] Iohexol was dissolved in physiological saline at a ratio of 300 mg / ml to prepare a developer. The solid resin was polyvinyl acetate (PVAC). Polydimethylsiloxane (PDMS) was solidified into a multi-channel module 6 (100 mm × 20 mm × 10 mm), the cross-sections of the left channel 9 and the right channel 11 were circular with a diameter of 300 um, and the cross-section of the middle channel 10 was circular with a diameter of 450 um. The injection submodule 4 was controlled to inject the developer 5 at intervals of 2S, and the flow rate was set to 0.5 ul / min. The output flow rate of the liquid resin in the feeding module 2 was controlled to be 0.5 ul / min. The ultraviolet light source was a light-emitting diode (LED) with a wavelength of 400 nm and a power of 20 w. The weaving module 15 was a 16-spindle weaving mechanism. The shell wire material was non-absorbable ultra-high molecular weight polyethylene (UHMWPE) fiber. Operation steps: Add the corresponding solvent to the feeding module 2 and the injection submodule 4. When the liquid flow rate of the left channel 9 and the right channel 11 is stable, start the injection submodule 4. When the liquid flow rate of the middle channel 10 is stable, adjust the roller speed through the control panel 3, turn on the ultraviolet lamp in the curing module 7, and adjust the movable roller 12 to the appropriate position to detect the breaking strength of the core wire. The breaking strength needs to be above 15N. After the core wire 17 is cleaned and air showered, it enters the weaving module 15 to start weaving the shell wire 18. At the same time, the X-ray source is turned on to detect the development effect. Finally, No. 5 suture that meets the design requirements is produced. The measured wire diameter range is 0.708-0.791mm, and the average breaking strength is 112N, which meets the YY0167-2020 non-absorbable surgical suture standard. As shown in Table 1.

[0060] Example 2

[0061] A method for preparing a suture with a developing function comprises the following steps:

[0062] Dissolve iodine hexamethylenetetramine in physiological saline at a ratio of 300 mg / ml to prepare a developer. The solid resin is polyvinyl acetate (PVAC). The polydimethylsiloxane (PDMS) is solidified into a multi-channel module 6 (80 mm × 20 mm × 10 mm), the cross-sections of the left channel 9 and the right channel 11 are circular with a diameter of 200 um, and the cross-section of the middle channel 10 is a circular with a diameter of 300 um. The injection submodule 4 is controlled to inject the developer 5 at an interval of 1.5 s, and the flow rate is set to 0.7 ul / min. The output flow rate of the liquid resin in the feeding module 2 is controlled to be 0.7 ul / min. The ultraviolet light source is a light-emitting diode (LED) with a wavelength of 400 nm and a power of 20 w. The weaving module 15 uses a 16-spindle weaving mechanism. The shell wire 18 material is absorbable polyvinyl alcohol fiber. The breaking strength is controlled to be above 10N, and the remaining operation steps are the same as above. Finally, a No. 2 suture that meets the design requirements was produced, with a measured wire diameter range of 0.505-0.596 mm and an average breaking strength of 85 N, which meets the YY1116-2020 absorbable surgical suture standard. As shown in Table 1.

[0063] Example 3

[0064] A method for preparing a suture with a developing function comprises the following steps:

[0065] Dissolve diatrizoate in physiological saline at a ratio of 300 mg / ml to prepare a developer. Polyvinyl acetate (PVAC) is used as the liquid resin. Polydimethylsiloxane (PDMS) is solidified into a multi-channel module 6 (80 mm × 20 mm × 10 mm), the cross-sections of the left channel 9 and the right channel 11 are circular with a diameter of 200 um, and the cross-section of the middle channel 10 is circular with a diameter of 300 um. Control the injection submodule 4 to inject the developer 5 at intervals of 1.5 s, and set the flow rate to 0.8 ul / min. Control the output flow rate of the liquid resin in the feeding module 2 to be 0.8 ul / min. The ultraviolet light source is a light-emitting diode (LED) with a wavelength of 400 nm and a power of 20 w. The weaving module 15 uses a 12-spindle weaving mechanism. The shell wire 18 material is absorbable polyglycolic acid fiber. The remaining operation steps are the same as above. Finally, a No. 1 suture that meets the design requirements was produced, with a measured wire diameter range of 0.406-0.495 mm and an average breaking strength of 60 N, which meets the YY1116-2020 absorbable surgical suture standard. As shown in Table 1.

[0066] Example 4

[0067] A method for preparing a suture with a developing function comprises the following steps:

[0068] The gadolinium developer is dissolved in physiological saline at a ratio of 300 mg / ml to prepare a developer. The liquid resin is polylactic acid (PLA). The polydimethylsiloxane (PDMS) is solidified into a multi-channel module 6 (50 mm × 15 mm × 5 mm), the cross-sections of the left channel 9 and the right channel 11 are circular with a diameter of 100 um, and the cross-section of the middle channel 10 is a circular with a diameter of 150 um. The injection submodule 4 is controlled to inject the developer 5 at intervals of 1S, and the flow rate is set to 1ul / min. The output flow rate of the liquid resin in the feeding module 2 is controlled to be 1ul / min. The ultraviolet light source is a light-emitting diode (LED) with a wavelength of 400nm and a power of 15w. The weaving module 15 uses a 16-spindle weaving mechanism. The shell wire 18 material is absorbable polyglycolide (PGA) fiber. The breaking strength is controlled to be above 5N, and the remaining operation steps are the same as above. Finally, a No. 0 suture that meets the design requirements was produced, with a measured wire diameter range of 0.355-0.398 mm and an average breaking strength of 45 N, which meets the YY1116-2020 absorbable surgical suture standard. As shown in Table 1.

[0069] Example 5

[0070] A method for preparing a suture with a developing function comprises the following steps:

[0071] Dissolve diatrizoate in physiological saline at a ratio of 300 mg / ml to prepare a developer. Polylactic acid is selected as the solid resin. Polydimethylsiloxane (PDMS) is solidified into a multi-channel module 6 (50 mm×15 mm×5 mm), the cross-sections of the left channel 9 and the right channel 11 are circular with a diameter of 100 um, and the cross-section of the middle channel 10 is a circular with a diameter of 150 um. Control the injection submodule 4 to inject the developer 5 at intervals of 1S, and set the flow rate to 1.1 ul / min. Control the output flow rate of the liquid resin in the feeding module 2 to be 1.1 ul / min. The ultraviolet light source is a light-emitting diode (LED) with a wavelength of 400 nm and a power of 15 w. The weaving module 15 uses a 12-spindle weaving mechanism. The shell wire 18 material is absorbable poly(lactide) fiber. The remaining operation steps are the same as above. Finally, the No. 2-0 suture that meets the design requirements was produced, with a measured wire diameter range of 0.306-0.343 mm and an average breaking strength of 37 N, which meets the YY1116-2020 absorbable surgical suture standard. As shown in Table 1.

[0072] Example 6

[0073] A method for preparing a suture with a developing function comprises the following steps:

[0074] Iohexol and iohexol were mixed in a ratio of 1:1 and dissolved in physiological saline at a ratio of 300 mg / ml to prepare a developer. Epoxy resin was selected as the liquid resin. Polydimethylsiloxane (PDMS) was solidified into a multi-channel module 6 (120 mm × 25 mm × 20 mm), the cross-sections of the left channel 9 and the right channel 11 were circular with a diameter of 400 um, and the cross-section of the middle channel 10 was circular with a diameter of 600 um. The injection submodule 4 was controlled to inject the developer 5 at intervals of 2.5 s, and the flow rate was set to 0.3 ul / min. The output flow rate of the liquid resin in the feeding module 2 was controlled to be 0.3 ul / min. The ultraviolet light source was a light-emitting diode (LED) with a wavelength of 400 nm and a power of 20 w. The weaving module 15 was a 13-spindle weaving mechanism. The shell wire material 18 was non-absorbable polyester fiber. The breaking strength was controlled to be above 20 N, and the remaining operation steps were the same as above. Finally, a 2mm suture that meets the design requirements was produced, with a measured wire diameter range of 1.800-2.299mm and an average breaking strength of 110N, which meets the YY0167-2020 non-absorbable surgical suture standard. As shown in Table 1.

[0075] Example 7

[0076] A method for preparing a suture with a developing function comprises the following steps:

[0077] Iohexol and diatrizoate were mixed in a ratio of 1:2 and dissolved in physiological saline at a ratio of 300 mg / ml to prepare a developer. Epoxy resin was selected as the liquid resin. Polydimethylsiloxane (PDMS) was solidified into a multi-channel module 6 (100 mm × 20 mm × 10 mm), the cross-sections of the left channel 9 and the right channel 11 were circular with a diameter of 300 um, and the cross-section of the middle channel 10 was circular with a diameter of 450 um. The injection submodule 4 was controlled to inject the developer 5 at intervals of 2S, and the flow rate was set to 0.5 ul / min. The output flow rate of the liquid resin in the feeding module 2 was controlled to be 0.5 ul / min. The ultraviolet light source was a light-emitting diode (LED) with a wavelength of 400 nm and a power of 20 w. The weaving module 15 was a 13-spindle weaving mechanism. The shell wire 18 material was non-absorbable nylon fiber. The breaking strength was controlled to be above 15N, and the rest of the operation steps were the same as above. Finally, a 1.5 mm suture that meets the design requirements was produced, with a measured wire diameter range of 1.500-1.799 mm and an average breaking strength of 73 N, which meets the YY0167-2020 non-absorbable surgical suture standard. As shown in Table 1.

[0078] Example 8

[0079] A method for preparing a suture with a developing function comprises the following steps:

[0080] Iohexol and diatrizoate were mixed in a ratio of 2:3 and dissolved in physiological saline at a ratio of 300 mg / ml to prepare a developer. Epoxy resin was selected as the liquid resin. Polydimethylsiloxane (PDMS) was solidified into a multi-channel module 6 (80 mm × 20 mm × 10 mm), the cross-sections of the left channel 9 and the right channel 11 were circular with a diameter of 300 um, and the cross-section of the middle channel 10 was circular with a diameter of 450 um. The injection submodule 4 was controlled to inject the developer 5 at intervals of 2S, and the flow rate was set to 0.5 ul / min. The output flow rate of the liquid resin in the feeding module 2 was controlled to be 0.5 ul / min. The ultraviolet light source was a light-emitting diode (LED) with a wavelength of 400 nm and a power of 20 w. The weaving module 15 was a 13-spindle weaving mechanism. The shell wire 18 material was non-absorbable polypropylene fiber. The breaking strength was controlled to be above 10N, and the remaining operation steps were the same as above. Finally, a 1mm suture that meets the design requirements was produced, with a measured wire diameter range of 0.500-1.499mm and an average breaking strength of 55N, which meets the YY0167-2020 non-absorbable surgical suture standard. As shown in Table 1.

[0081] Table 1

[0082]

[0083] It can be seen that the preparation methods of the products in various embodiments are similar, and the main differences are: (1) the selection of developer, which can be selected from one or more of iohexol, iohexol, diatrizoate, and gadolinium developer; (2) the selection of resin, which can be selected from liquid resin or solid resin powder, and the solid resin powder needs to be heated and melted into liquid resin, and can be selected from one of epoxy resin, polylactic acid, and polyvinyl acetate; (3) the size of the multi-channel module and the channel size need to be determined according to the final size of the product, and the corresponding multi-channel module needs to be replaced to prepare different products. The multi-channel module can be solidified by dimethylsiloxane (PDMS) or prepared by precision processing methods such as 3D printing; (4) The shell wire braiding material can be made of non-absorbable materials, including one of ultra-high molecular weight polyethylene fiber, polyester fiber, polypropylene fiber, and nylon fiber, or absorbable materials, including one of polyvinyl alcohol fiber, polyglycolide fiber, polypropylene glycolide fiber, polydioxanone fiber, collagen fiber, polyglycolic acid fiber, and polyglycol carbonate fiber; (5) The preparation parameters need to be adjusted according to the product size specifications and the feedback information collected by the system, including the injection developer flow rate, injection interval time, liquid resin flow rate, ultraviolet light source parameters, breaking force parameters, braiding parameters, etc.

[0084] The above description of the disclosed embodiments enables one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A system for preparing sutures with a developing function, characterized in that: It includes a feeding module, a multi-channel module, a curing module which are sequentially connected through connecting pipes, and a breaking strength detection module, a cleaning tank, an air shower chamber, a braiding module, and an X-ray detection module into which the core wires are sequentially transported by a plurality of rollers; The multi-channel module includes a left channel, a right channel and a middle channel; the left channel and the right channel are symmetrically distributed on both sides of the middle channel and intersect at the middle channel; The discharge port of the feeding module is divided into two branches, which are respectively connected to the feed ports of the left channel and the right channel; The feeding module further comprises an injection submodule, the discharge port of the injection submodule is connected to the feed port of the middle channel; the injection submodule is controlled so that the developer is wrapped in the solid resin, thereby achieving uniform distribution of the developer in the developer seam; The suture thread comprises a core thread and a shell thread; the shell thread is made of absorbable material or non-absorbable material.

2. A system for preparing suture thread with developing function according to claim 1, characterized in that: The breaking strength detection module comprises a movable roller. By controlling the position of the movable roller relative to the core wire, the core wire is tightened so as to apply a predetermined tension thereto.

3. The system for preparing suture thread with developing function according to claim 1, characterized in that: Also includes a control panel and a device housing; The control panel is interconnected with other modules, and the control panel is used to control the rotation speed of each module and the roller, and at the same time, feedback signals from each module are received; The plurality of rollers are fixed on the device housing.

4. The system for preparing suture thread with developing function according to claim 3, characterized in that: The control panel includes a touch screen display, which displays status information and feedback signal information of each module; The touch screen can control the heating temperature of the feeding module, the injection parameters of the injection submodule, the switch of the UV lamp in the curing module and the irradiation time, the position parameters of the movable roller in the breaking strength detection module and the monitoring of the core wire tension, the depth of the cleaning liquid injected into the cleaning tank, the switch of the air shower chamber and the air shower time, the weaving parameters of the weaving module, the switch of the X-ray light source in the X-ray detection module and the monitoring of the development effect of the suture line in the X-ray image, and the rotation speed of the roller.

5. A method for preparing a suture with a developing function, using the preparation system according to any one of claims 1 to 4, characterized in that: The steps include: (1) Loading: Add solid resin powder into the loading module, turn on the heating switch on the control panel to melt the powder into liquid resin, or turn off the heating switch and directly add liquid resin into the loading module, and add developer into the injection submodule at the same time; (2) Polymerization: In the multi-channel module, the liquid resin wraps the developer so that the developer is in a middle horizontal position and is evenly distributed axially in the liquid resin. The axial spacing of the developer in the liquid resin is controlled by the injection speed of the developer; (3) Curing: The liquid resin wrapped in the developer is introduced into the curing module, and the liquid resin is cured under ultraviolet light to obtain a core wire; (4) Breaking strength test: The core wire obtained after the liquid resin is cured is introduced into the breaking strength test module. The tension between the core wires is adjusted by changing the position of the moving roller through the control panel to test the quality of the core wire. (5) Cleaning and drying: After the breaking strength test, the core wire enters the cleaning tank for cleaning, and then enters the air shower chamber for drying; (6) Shell wire weaving: the cleaned and dried core wire is introduced into the weaving module, and the shell wire is weaved outside the core wire to obtain the developed suture wire; (7) Development effect detection: The development suture line is introduced into the X-ray detection module, the X-ray source switch on the control panel is turned on, and the development effect is observed on the display screen. When the expected effect is achieved, continuous production can be carried out.

6. The method for preparing a suture thread with a developing function according to claim 5, characterized in that: The solid resin is selected from one of polylactic acid and polyvinyl acetate; the liquid resin is selected from one of epoxy resin and polyvinyl acetate; the developer is selected from one or more of iohexol, iohexol, diatrizoate, and gadolinium developer.

7. The method for preparing a suture with a developing function according to claim 5, characterized in that: The injection submodule is controlled to inject the developer into the middle channel at the same interval, each interval is 0.1-2.5s, and the flow rate is 0.3-1.2ul / min.

8. The method for preparing a suture thread with a developing function according to claim 5, characterized in that: The irradiation time of the ultraviolet light in the curing module is greater than 35 seconds.

9. The suture thread prepared by the method according to any one of claims 5 to 8, characterized in that: The suture wire comprises a core wire and a shell wire, the core wire is composed of a developer and a resin, and the developer in the core wire is distributed equidistantly along the axial direction.

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