Novel pesticide composition

Abstract

The present invention relates to a pesticide composition comprising an effective amount of trifluoropyrimidine; an effective amount of tebuconazole; an effective amount of tricyclazole; and at least one agrochemically acceptable excipient. The present invention in particular relates to a pesticide composition comprising trifluoropyrimidine accounting for 0.1% w / w to 20% w / w of the total composition; tebuconazole accounting for 1% w / w to 50% w / w of the total composition; tricyclazole accounting for 10% w / w to 70% w / w of the total composition; and at least one agrochemically acceptable excipient. The invention also relates to a method for preparing the pesticide composition. The present invention relates to a method for treating a plant, crop, plant propagation material, locus or part thereof, seed, seedling or surrounding soil with a pesticide composition.

Description

1. Field of the Invention

[0001] The present invention relates to a pesticide combination, including triflupyrimidine, tebuconazole and tricyclazole. The present invention relates to a pesticide composition, including a combination of an effective amount of triflupyrimidine, an effective amount of tebuconazole, an effective amount of tricyclazole and at least one agrochemically acceptable excipient. The present invention particularly relates to a pesticide composition, including: 0.1% w / w to 20% w / w of triflupyrimidine in the total composition; 1% w / w to 50% w / w of tebuconazole in the total composition; 10% w / w to 70% w / w of tricyclazole in the total composition; and at least one agrochemically acceptable excipient. The particle size range of the pesticide composition is 0.1 micron to 75 microns.

[0002] The present invention also relates to a method for preparing a pesticide composition, which comprises: 0.1% w / w to 20% w / w of trifluridine in the total composition; 1% w / w to 50% w / w of tebuconazole in the total composition; 10% w / w to 70% w / w of tricyclazole; and at least one agrochemically acceptable excipient.

[0003] The present invention also relates to a method for controlling fungal diseases, protecting crops or improving plant health or yield by treating plants, crops, plant propagation materials, loci or parts thereof, seeds, seedlings or surrounding soil with the pesticide composition of the present invention. 2. Background of the invention

[0005] When describing the embodiments of the present invention, specific terms are selected for clarity. However, the present invention is not limited to the specific terms so selected, and it should be understood that each specific term includes all technical equivalents that operate in a similar manner to achieve similar purposes.

[0006] Rice is the staple food of about half of the world's population. However, its production is greatly affected by insects, pests and diseases. Insects damage crops by directly eating them, and infect them with bacteria and fungi. While destructive viral diseases are not found in any rice-growing region of the world, fungal and bacterial diseases are widespread, affecting the growth and yield of rice crops and sometimes completely destroying the crops. These diseases lead to both direct and indirect crop losses. For example, direct losses include grain spots, low grain numbers, lodging, reduced plant stand and reduced plant efficiency, while indirect losses include the cost of pesticides used to control insects and diseases, yield reduction and special agronomic practices. Therefore, the management of insects and diseases is essential to achieve sustainable rice production.

[0007] The use of agrochemicals, especially pesticides, to protect crops from fungi, insects and other pests has become an integral part of crop management. The fungicides and pesticides currently on the market do not meet modern crop protection requirements because they:

[0008] Lack of broad-spectrum effects

[0009] Increased resistance of pests due to repeated and prolonged application of a single active ingredient or known high doses of chemicals,

[0010] Environmental pollution and soil toxicity are caused by the leaching of pesticides into soil and groundwater.

[0011] In addition, repeated use of current pesticide products poses risks of pest recurrence, secondary pest outbreaks, residue-related problems, toxic effects on humans, and reduced yields.

[0012] Furthermore, the use of compositions containing multiple pesticides with different chemical and physical properties can cause various problems, such as improper mixing ratios, incompatible formulated products, and potential hazards to personnel who are not trained in the proper mixing of products. In addition, combining and preparing stable formulations containing multiple pesticides is also critical, as the pesticides contained in the composition must not only be compatible, but also have a long shelf life and high stability, and exhibit effective activity before final use.

[0013] Therefore, there is a clear need for improved pesticide products that address the above-mentioned drawbacks associated with known chemicals. In addition, it is desirable to develop a new pesticide composition with modern integrated pest management that not only improves toxicological and environmental profiles but also significantly broadens the crop protection spectrum while improving stability and safety for the end user.

[0014] Trifluanid is a mesoionic pesticide that exhibits effective biological activity in controlling sucking insects such as planthoppers in rice crops.

[0015] Tebuconazole is a systemic triazole fungicide that inhibits the demethylation of the sterol precursor ergosterol in fungi.

[0016] Tricyclazole is a systemic fungicide that inhibits melanin formation in fungi. Tricyclazole is best known for its use in controlling rice blast.

[0017] Bidirectional combinations of the fungicidal active ingredients tricyclazole and tebuconazole for controlling pathogens and insect pests in rice crops are commercially available and described in the literature. However, the biological properties of these known combinations are not completely satisfactory in terms of pathogen control, phytotoxicity and environmental exposure.

[0018] CN101103724 relates to a synergistic fungicidal compound comprising tricyclazole and tebuconazole.

[0019] WO2012092115A1 relates to mesoionic pyrido[1,2-A]pyrimidine pesticides. WO'115 discusses thousands of possible fungicide combinations containing mesoionic pyrido[1,2-A]pyrimidine compounds of formula (I). WO'115 discusses bidirectional combinations of trifluoropyrimidine and tricyclazole.

[0020] IN201721013568 relates to a pesticide combination comprising A) pymetrozine, B) a pesticide and C) a fungicide.

[0021] However, these documents do not mention the specific combination of trifluridine, tebuconazole and tricyclazole at an effective amount of pesticide and a specific particle size; and the efficacy and synergistic effect of the combination.

[0022] Therefore, there is no known pesticide composition in the art, which comprises a specific combination of trifluridine, tebuconazole and tricyclazole, which can be effectively used, has a broad-spectrum pesticide activity, and solves the disadvantages of the above-mentioned known compositions.

[0023] The present invention addresses this need by providing stable and improved pesticide combinations. 3. Summary of the Invention

[0025] The present invention relates to a synergistic combination comprising trifluoropyrimidine, tebuconazole and tricyclazole.

[0026] The invention relates to a pesticide composition, which comprises: an effective amount of triflupyrimidine; an effective amount of tebuconazole; an effective amount of tricyclazole; and at least one agrochemically acceptable excipient.

[0027] The present invention relates to a pesticide composition, which comprises: 0.1% w / w to 20% w / w of triflupyrimidine in the total composition; 1% w / w to 50% w / w of tebuconazole in the total composition; 10% w / w to 70% w / w of tricyclazole in the total composition; and at least one agrochemically acceptable excipient.

[0028] In addition, the present invention relates to a pesticide composition comprising: 0.1% w / w to 20% w / w of trifluridine in the total composition; 1% w / w to 50% w / w of tebuconazole in the total composition; 10% w / w to 70% w / w of tricyclazole in the total composition; and at least one agrochemically acceptable excipient, wherein the composition comprises microparticles having a size range of 0.1 microns to 75 microns.

[0029] The present invention also relates to a method for preparing a pesticide composition, which comprises: 0.1% w / w to 20% w / w of trifluoropyrimidine in the total composition; 1% w / w to 50% w / w of tebuconazole in the total composition; 10% w / w to 70% w / w of tricyclazole in the total composition; and at least one agrochemically acceptable excipient.

[0030] According to another embodiment, the present invention also relates to a method for protecting crops or improving their health or yield by treating at least one of the plants, crops or parts thereof, plant propagation materials, seeds, seedlings or surrounding soil with a pesticide composition, wherein the pesticide composition comprises: an effective amount of trifluridine, an effective amount of tebuconazole, an effective amount of tricyclazole and at least one agrochemically acceptable excipient.

[0031] 4. Detailed Description of the Invention

[0032] When describing the embodiments of the present invention, specific terms are selected for clarity. However, the present invention is not limited to the selected specific terms, and it should be understood that these specific terms include all technical equivalents that operate in a similar manner to achieve similar purposes. It should be understood that any numerical range described herein is intended to include all sub-ranges. In addition, unless otherwise stated, the percentage of components in the composition is expressed in weight percentage.

[0033] The terms "a" or "an", as used herein, are defined as one or more. The terms "including" and / or "having", as used herein, are defined as comprising (ie, open language).

[0034] The trifluoropyrimidine used in the present invention refers to trifluoropyrimidine or a salt or derivative thereof.

[0035] Tebuconazole used in the present invention refers to tebuconazole or a salt or a derivative thereof.

[0036] The tricyclazole used in the present invention refers to tricyclazole or a salt or a derivative thereof.

[0037] Granules mainly refer to water-dispersible granules, extruded granules or spheronized granules. As described herein, "GR" refers to extruded granules or spheronized granules. As described herein, "WG" or "WDG" refers to water-dispersible granules.

[0038] As used herein, water dispersible granules are defined as formulations that disperse or dissolve rapidly upon addition to water to form a finely divided microparticle suspension. Water dispersible granules are formulated by mixing and agglomerating the finely divided active ingredient with a surfactant and other formulation excipients into small, easily measured granules that disperse into finer / primary particles upon addition of water.

[0039] According to the present invention, the term "liquid suspension" includes "aqueous suspension" or "aqueous dispersion" or "suspension concentrate (SC)" compositions. Liquid suspensions are defined as compositions in which solid particles are dispersed or suspended in a liquid. The liquid as carrier is water and / or a water-miscible solvent.

[0040] As defined herein, WP refers to wettable powder, which is a dust formulation that is applied as a suspension after dispersion in water.

[0041] As defined herein, WS refers to water dispersible powders for slurry seed treatment.

[0042] As defined herein, an aqueous suspoemulsion is essentially a mixture of water-insoluble active ingredients dispersed in a water-based solution; wherein one (or more) active ingredient(s) is a solid formulated as a suspension form (SC) and one (or more) active ingredient(s) is an oil formulated as an emulsion in water (EW).

[0043] The present invention relates to a synergistic combination comprising trifluoropyrimidine, tebuconazole and tricyclazole.

[0044] The present invention relates to a pesticide composition, characterized by comprising an effective amount of trifluconazole, an effective amount of thiamethoxam, an effective amount of tricyclazole and at least one agriculturally acceptable carrier.

[0045] The present invention relates to a pesticide composition, comprising: 0.1% w / w to 20% w / w of triflupyrimidine in the total composition; 1% w / w to 50% w / w of tebuconazole in the total composition; 10% w / w to 70% w / w of tricyclazole in the total composition; and at least one agrochemically acceptable excipient.

[0046] In addition, the present invention relates to a pesticide composition comprising: 0.1% w / w to 20% w / w of trifluridine based on the total composition; 1% w / w to 50% w / w of tebuconazole based on the total composition; 10% w / w to 70% w / w of tricyclazole based on the total composition; and at least one agrochemically acceptable excipient, wherein the composition comprises microparticles having a size range of 0.1 microns to 75 microns.

[0047] The inventors of the present invention have surprisingly found that a combination comprising trifluridine, tebuconazole and tricyclazole exhibits synergistic pesticidal activity compared to the individual active ingredients alone.

[0048] The inventors of the present invention unexpectedly developed a stable and synergistic pesticide composition comprising a combination of triflupyrimidine, tebuconazole and tricyclazole. The inventors found that when the composition comprises a pesticide effective amount of triflupyrimidine, a pesticide effective amount of tebuconazole, and a pesticide effective amount of tricyclazole, it has a synergistic effect and exhibits excellent field efficacy in protecting rice crops from very serious pests and diseases, namely brown planthopper (BPH), white-backed planthopper (WBPH), rice blast, sheath blight, rice false smut and grain discoloration.

[0049] The inventors unexpectedly found that the composition comprising triflupromide, tebuconazole and tricyclazole not only has synergistic effects, but is also a high-quality crop protection agent without phytotoxicity. In addition, the pesticide composition helps in the management of chemical resistance of old pesticides and can also increase yield when applied in the field.

[0050] In addition, the compositions of the present invention exhibit excellent physical properties, such as suspensibility, dispersibility, flowability, wettability, pourability and improved viscosity. The compositions of the present invention also exhibit excellent performance under accelerated storage conditions and are found to be effective in drip irrigation. The compositions of the present invention not only provide surprising results as crop protection agents, but also act as yield enhancers.

[0051] In addition to the synergistic effects of the compositions of the present invention, the inventors have unexpectedly determined that a composition comprising: 0.1% w / w to 20% w / w of trifluridine, 1% w / w to 50% w / w of tebuconazole, 10% w / w to 70% w / w of tricyclazole, and at least one agrochemically acceptable excipient in solid, liquid or gel form, can provide excellent pest control and increase yield when the particle size range of the composition is 0.1 micron to 75 microns.

[0052] According to an embodiment, trifluoropyrimidine is in the range of 0.1% w / w to 20% w / w of the total composition. According to an embodiment, trifluoropyrimidine is in the range of 0.1% w / w to 10% w / w of the total composition. According to an embodiment, trifluoropyrimidine is in the range of 0.1% w / w to 8% w / w of the total composition.

[0053] According to an embodiment, tebuconazole is in the range of 1% w / w to 50% w / w of the total composition. According to an embodiment, tebuconazole is in the range of 1% w / w to 40% w / w of the total composition. According to an embodiment, tebuconazole is in the range of 1% w / w to 30% w / w of the total composition. According to an embodiment, tebuconazole is in the range of 1% w / w to 20% w / w of the total composition. According to an embodiment, tebuconazole is in the range of 1% w / w to 10% w / w of the total composition.

[0054] According to one embodiment, tricyclazole is in the range of 10% to 70% w / w of the total composition. According to one embodiment, tricyclazole is in the range of 10% to 60% w / w of the total composition. According to one embodiment, tricyclazole is in the range of 10% to 50% w / w of the total composition. According to one embodiment, tricyclazole is in the range of 10% to 40% w / w of the total composition. According to one embodiment, tricyclazole is in the range of 10% to 30% w / w of the total composition. According to one embodiment, tricyclazole is in the range of 10% to 20% w / w of the total composition.

[0055] According to one embodiment, the liquid pesticide composition can be a combination of a solution, a suspension, an emulsion, an oil dispersion, a liquid suspension, a soluble liquid, a flowable concentrate, an emulsifiable concentrate, a seed dressing, a suspension emulsion, a capsule suspension, an emulsion in water, an ultra low volume concentrate (ULV), a capsule suspension and a suspension concentrate (ZC).

[0056] According to one embodiment, the liquid pesticide composition may preferably be in the form of a suspension concentrate.

[0057] According to one embodiment, the liquid pesticide composition may preferably be in the form of an emulsion concentrate.

[0058] According to one embodiment, the solid pesticide composition may be in the form of powder, granules or dust.

[0059] According to one embodiment, the pesticide composition can be in the form of a powder, including a wettable powder and a dispersible powder. According to one embodiment, the pesticide composition can be in the form of a granule, including a broadcast granule, a pellet, an extruded granule, a water-dispersible granule, a water-disintegrating granule, a dry capsule suspension, and a dry ZC composition (a combination of a capsule suspension and a suspension concentrate).

[0060] According to one embodiment, the pesticide composition may preferably be in the form of wettable granules.

[0061] According to one embodiment, the pesticide composition may preferably be in the form of water-dispersible granules.

[0062] According to one embodiment, the pesticide composition may preferably be in the form of water-disintegrable granules.

[0063] According to one embodiment, the pesticide composition may include granules with a size range of 0.025mm to 6mm. According to one embodiment, the pesticide composition may include granules with a size range of 0.025mm to 5mm. According to one embodiment, the pesticide composition may include granules with a size range of 0.025mm to 4mm. According to one embodiment, the pesticide composition may include granules with a size range of 0.025mm to 3mm. According to one embodiment, the pesticide composition may include granules with a size range of 0.025mm to 2mm. According to one embodiment, the size range of the granules of the pesticide composition is 0.025mm to 1.5mm.

[0064] According to one embodiment, the pesticide composition may be in the form of water-disintegrating granules, wherein the size of the granules ranges from 0.025 mm to 6 mm. According to one embodiment, the pesticide composition may be in the form of water-disintegrating granules, wherein the size of the granules ranges from 0.025 mm to 5 mm. According to one embodiment, the pesticide composition may be in the form of water-disintegrating granules, wherein the size of the granules ranges from 0.025 mm to 4 mm. According to one embodiment, the pesticide composition may be in the form of water-disintegrating granules, wherein the size of the granules ranges from 0.025 mm to 3.5 mm.

[0065] According to one embodiment, the pesticide composition may be in the form of water-dispersible granules, wherein the size of the granules ranges from 0.025 mm to 3 mm. According to one embodiment, the pesticide composition may be in the form of water-dispersible granules, wherein the size of the granules ranges from 0.025 mm to 2.5 mm. According to one embodiment, the pesticide composition may be in the form of water-dispersible granules, wherein the size of the granules ranges from 0.025 mm to 2.0 mm. According to one embodiment, the pesticide composition may be in the form of water-dispersible granules, wherein the size of the granules ranges from 0.025 mm to 1.5 mm.

[0066] According to one embodiment, the pesticide composition may include microparticles having a size range of 0.1 micron to 75 microns. According to further embodiments, the pesticide composition may include microparticles having a size range of 0.1 micron to 50 microns. According to further embodiments, the pesticide composition may include microparticles having a size range of 0.1 micron to 40 microns. According to further embodiments, the pesticide composition may include microparticles having a size range of 0.1 micron to 25 microns. According to further embodiments, the pesticide composition may include microparticles having a size range of 0.1 micron to 15 microns.

[0067] According to one embodiment, the pesticide composition in the form of water-disintegrable microparticles may include microparticles with a size range of 0.1 micron to 75 micron. According to one embodiment, the pesticide composition in the form of water-disintegrable microparticles may include microparticles with a size range of 0.1 micron to 50 micron. According to one embodiment, the pesticide composition in the form of water-disintegrable microparticles may include microparticles with a size range of 0.1 micron to 30 micron.

[0068] According to one embodiment, the pesticide composition in the form of water-dispersible granules may include microparticles having a size range of 0.1 micron to 50 microns. According to one embodiment, the pesticide composition in the form of water-dispersible microparticles may include microparticles having a size range of 0.1 micron to 30 microns. According to one embodiment, the pesticide composition in the form of water-dispersible microparticles may include microparticles having a size range of 0.1 micron to 25 microns. According to one embodiment, the pesticide composition in the form of water-dispersible microparticles may include microparticles having a size range of 0.1 micron to 20 microns.

[0069] According to one embodiment, the pesticide composition comprises at least one agrochemically acceptable excipient.

[0070] According to one embodiment, the agrochemically acceptable excipient accounts for 1% w / w to 89% w / w of the total composition. According to one embodiment, the agrochemically acceptable excipient accounts for 1% w / w to 80% w / w of the total composition. According to one embodiment, the agrochemically acceptable excipient accounts for 5% w / w to 70% w / w of the total composition. According to one embodiment, the agrochemically acceptable excipient accounts for 1% w / w to 60% w / w of the total composition. According to one embodiment, the agrochemically acceptable excipient accounts for 1% w / w to 50% w / w of the total composition. According to one embodiment, the agrochemically acceptable excipient accounts for 1% w / w to 40% w / w of the total composition. According to one embodiment, the agrochemically acceptable excipient accounts for 1% w / w to 30% w / w of the total composition. According to one embodiment, the agrochemically acceptable excipient accounts for 1% w / w to 20% w / w of the total composition. According to one embodiment, the agrochemically acceptable excipient comprises 1% w / w to 10% w / w of the total composition.

[0071] According to further embodiments, the acceptable excipients in agrochemicals may include at least one of adjuvants, surfactants, wetting agents, emulsifiers, adhesives or binding agents, disintegrants, fillers or carriers or diluents, coating agents, buffers or pH regulators or neutralizers, defoamers or defoamers, penetrants, UV protectants, stabilizers, pigments, colorants, structurants, chelating agents or complexing agents or chelating agents, thickeners, suspending agents or suspension aids or anti-caking agents or anti-settling agents, viscosity modifiers or rheology modifiers, tackifiers, humectants, adhesives, antifreeze agents or freezing point depressants, solvents and mixtures thereof. However, those skilled in the art will appreciate that additional acceptable excipients in agrochemicals may be used without departing from the scope of the invention.

[0072] According to one embodiment, the pesticide composition in the form of water-dispersible or spherical granules also includes at least one agrochemical excipient, including disintegrants, surfactants, binders or fillers or carriers or diluents, defoamers, ultraviolet absorbers, ultraviolet scatterers, anti-caking agents or anti-settling agents or suspension aids or suspending agents, penetrants, adhesives, tackifiers, pigments, colorants, stabilizers, dispersants and wetting agents. However, those skilled in the art will appreciate that additional agrochemically acceptable excipients may be used without departing from the scope of the present invention.

[0073] According to one embodiment, the liquid pesticide composition further comprises at least one agrochemical excipient, the excipient comprising at least one structurant, surfactant, humectant, water miscible solvent, suspending agent or suspension aid or anti-caking agent or anti-settling agent, penetrant, adhesive, UV absorber, UV scatterer, buffer or pH regulator or neutralizer, stabilizer, antifreeze agent or freezing point depressant, defoamer. However, those skilled in the art will appreciate that additional agrochemically acceptable excipients may be used without departing from the scope of the present invention.

[0074] However, those skilled in the art will recognize that additional agrochemically acceptable excipients may be used without departing from the scope of the present invention.Agrochemically acceptable excipients are commercially manufactured and available through various companies.

[0075] According to one embodiment, the surfactant includes one or more of an emulsifier, a wetting agent and a dispersant. According to one embodiment, the surfactant used in the pesticide composition includes one or more of anionic, cationic, nonionic, amphoteric and polymeric surfactants.

[0076] The anionic surfactant includes, but is not limited to, one or more of the following: fatty acid salts, benzoates, polycarboxylates, alkyl sulfate ester salts, alkyl ether sulfates, alkyl sulfates, alkyl aryl sulfates, alkyl diglycol ether sulfates, alcohol sulfate ester salts, alkyl sulfonates, alkyl aryl sulfonates, aryl sulfonates, lignin sulfonates, alkyl diphenyl ether disulfonates, polystyrene sulfonates, alkyl phosphate ester salts, alkyl aryl phosphates, styrylaryl phosphates, sulfonate docusates, salts of polyoxyethylene alkyl ether sulfates, polyoxyethylene alkyl aryl ether sulfates, alkyl sarcosinates, α-olefin sulfonic acid sodium salts, alkylbenzene sulfonates or their salts, sodium lauroyl sarcosinate, sulfosuccinates, polyacrylates, polyacrylate-free acid and sodium salts, polyoxyethylene alkyl aryl ether sulfates, polyoxyethylene alkyl ether phosphates, salts of polyoxyethylene alkyl aryl phosphates, sulfosuccinate-monoesters and other diesters, phosphates , alkylnaphthalene sulfonates - isopropyl and butyl derivatives, alkyl ether sulfates - sodium and ammonium salts, alkyl aryl ether phosphates, ethylene oxide and its derivatives, salts of polyoxyethylene aryl ether phosphates, monoalkyl sulfosuccinates, aromatic hydrocarbon sulfonates, 2-acrylamido-2-methylpropanesulfonic acid, ammonium dodecyl sulfate, docusate, ammonium perfluorononanoate, disodium coconut oil amphodiacetate, magnesium lauryl sulfate, perfluorobutanesulfonic acid, perfluorononanoic acid, carboxylates, perfluorooctanesulfonic acid, Perfluorooctanoic acid, lecithin, potassium dodecyl sulfate, soap, soap substitute, sodium alkyl sulfate, sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, sodium laurate, sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium myristyl sulfate, sodium nonanoyloxybenzene sulfonate, alkyl carboxylates, sodium stearate, α-olefin sulfonates, naphthalene sulfonates, alkyl naphthalene sulfonic acid fatty acid salts, naphthalene sulfonic acid condensate sodium salt, fluorocarboxylates, fatty alcohol sulfates, alkyl naphthalene sulfonic acid condensate-sodium salt, 700 polyoxyethylene (100) stearyl ether, L-77 silicone polyether copolymer, OT-B sodium dioctyl sulfosuccinate, naphthalenesulfonic acid condensed with formaldehyde or alkylnaphthalenesulfonate condensed with formaldehyde; or its salts or derivatives.

[0077] The nonionic surfactant includes, but is not limited to, one or more of the following: polyol esters, polyol fatty acid esters, polyethoxylated esters, polyethoxylated alcohols, ethoxylated and propoxylated fatty alcohols, ethoxylated and propoxylated alcohols, ethylene oxide (EO) / propylene oxide (PO) copolymers; EO and PO block copolymers, di- and tri-block copolymers; block copolymers of polyethylene glycol and polypropylene glycol, poloxamers, polysorbates, alkyl polysaccharides such as alkyl polyglycosides and blends thereof, amine ethoxylates, sorbitan fatty acid esters, ethylene glycol and glycerol esters, glucose Glycoside alkyl ether, sodium tallowate, polyoxyethylene glycol, sorbitan alkyl esters, sorbitan derivatives, sorbitan fatty acid esters (Spans) and ethoxylated derivatives (Tweens), fatty acid sucrose esters, hexadecyl alcohol, hexadecyl alcohol, cocamide diethanolamine (DEA), cocamide monoethanolamine (MEA), decyl glucoside, decyl polyglucose, glyceryl monostearate, lauryl glucoside, maltoside, glyceryl monolaurate, narrow range ethoxylates, ethylphenyl polyethylene glycol (Nonidet P-40), nonoxynol-9, nonylphenol, octaethylene glycol monododecyl ether, N-octyl β-D-pyranosyl glucoside, octyl glucoside, oleyl alcohol ethoxylate, PEG-10 sunflower glycerides, pentaethylene glycol monododecyl ether, polydocanol, poloxamer, poloxamer 407, polyethoxylated tallow amine, polyglyceryl polyricinoleate, polysorbate, polysorbate 20, polysorbate 80, sorbitol, sorbitan laurate, mono Sorbitol stearate, sorbitol tristearate, stearyl alcohol, surfactin, lauric acid glyceryl, lauryl glucoside, nonylphenol polyethoxyethanol, nonylphenol polyglycol ether, castor oil ethoxylate, polyethylene glycol ether, addition polymer of ethylene oxide and propylene oxide, block copolymer of polyalkylene glycol ether and hydroxystearic acid, tributylphenoxy polyethoxyethanol, octylphenoxy polyethoxyethanol, ethyl propoxylated tristyrylphenol, ethoxylated alcohol, polyoxyethylene Sorbitan, fatty acid polyglycerol esters, fatty acid alcohol polyglycol ethers, acetylene glycol, acetylene alcohol, oxyalkylene block polymers, polyoxyethylene alkyl ethers, polyoxyethylene alkyl aryl ethers, polyoxyethylene styryl aryl ethers, polyoxyethylene glycol alkyl ethers, polyethylene glycol, polyoxyethylene fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene glycerol fatty acid esters, alcohol ethoxylates - C6 to 06 / 18 alcohols (straight and branched), alcohol alkoxylates - various 1. Hydrophobes and EO / PO content and ratio, fatty acid esters - mono- and diesters; lauric, stearic and oleic; glycerides - with or without EO; lauric, stearic, cocoa and tall oil derived, ethoxylated glycerol, sorbitan esters (with or without EO); lauric, stearic and oleic; mono- and triesters, castor oil ethoxylates - 5 to 200 moles EO; non-hydrogenated and hydrogenated, block polymers, amine oxides - ethoxylated and non-ethoxylated;Alkyl dimethyl, fatty amine ethoxylates - coconut amine, tallow amine, stearyl amine, oleyl amine, polyoxyethylene hydrogenated castor oil or polyoxypropylene fatty acid esters; salts or their derivatives. ;

[0078] Amphoteric or zwitterionic surfactants include, but are not limited to, one or more of the following: betaine, cocoamidopropyl betaine, cocoalkyl dimethylamine oxide, alkyl dimethyl betaine; C8 to C18 alkyl dipropionate-sodium lauriminodipropionate, cocoamidopropyl hydroxysulfonate, imidazoline, phospholipids phosphatidylserine, phosphatidylethanolamine, phosphatidylcholine and sphingomyelin, lauryl dimethylamine oxide, alkyl amphoacetates and propionates, alkyl amphoacetates and dipropionates, lecithin and ethanolamine fatty amide; or their salts, derivatives.

[0079] Commercially available surfactants include, but are not limited to, one or more of the following trademarks: Atlas G5000, TERMUL5429, TERMUL 2510, 118. X. OX-080, C 100, EL 200, Arlacel P135, Hypermer 8261, Hypermer B239, Hypermer B261, Hypermer B246sf, Solutol HS15, Promulgen TM D. Soprophor 7961P, Soprophor TSP / 461, Soprophor TSP / 724, Croduret 40, Etocas 200, Etocas 29, RokacetR26, Cetomacrogol 1000, CHEMONIC OE-20, Triton N-101, Triton X-100, Tween 20, 40, 60, 65, 80, Span20, 40, 60, 80, 83, 85, 120, Atlox 4912, TERMUL 3512, TERMUL 3015, TERMUL 5429, TERMUL 2510, T85, T20, TERIC 12A4, IGEPAL CA-630 and Isoceteth-20.

[0080] However, one skilled in the art will appreciate that other conventionally known surfactants (ionic or nonionic) may be used without departing from the scope of the present invention. Surfactants are commercially manufactured and available through various companies.

[0081] According to one embodiment, the solvent is selected from water-miscible solvents, including but not limited to 1,4-dioxane, ethylene glycol, N-methyl-2-pyrrolidone, 1,3-propylene glycol, 1,5-pentanediol, propylene glycol, triethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, dimethylformamide, dimethoxyethane, dimethyloctanamide, glycerol, dimethyldecanamide. However, those skilled in the art will appreciate that other water-miscible solvents may be used without departing from the scope of the present invention.

[0082] According to one embodiment, the disintegrant used in the agricultural composition includes but is not limited to one or more of the following: inorganic water-soluble salts, such as sodium chloride, nitrates; water-soluble organic compounds, such as agar, hydroxypropyl starch, carboxymethyl starch ether, tragacanth gum, gelatin, casein, microcrystalline cellulose, cross-linked sodium carboxymethyl cellulose, carboxymethyl cellulose calcium, sodium tripolyphosphate, sodium hexametaphosphate, metal stearates, cellulose powder, dextrin, methacrylate copolymers, XL-10 (cross-linked polyvinyl pyrrolidone), polyvinyl pyrrolidone, sulfonated styrene-isobutylene-maleic anhydride copolymer, salts of polyacrylates or methacrylates, starch-polyacrylonitrile graft copolymers, sodium or potassium bicarbonate / carbonate or mixtures thereof or salts thereof with acids (e.g., citric acid and fumaric acid), derivatives thereof. However, it will be appreciated by those skilled in the art that different disintegrants may be used without departing from the scope of the present invention. Disintegrants are commercially produced and can be purchased from different companies.

[0083] According to one embodiment, the adhesive or sticking agent used for the agricultural composition includes, but is not limited to, one or more of: protein, gum, maltodextrin, carbohydrate (e.g., monosaccharide, disaccharide, oligosaccharide and polysaccharide), complex organic matter, synthetic organic polymer or derivative and combination thereof. However, it will be appreciated by those skilled in the art that different adhesives may be used without departing from the scope of the invention. Adhesives are commercially manufactured and are available from different companies.

[0084] According to one embodiment, the carrier for the agricultural composition includes, but is not limited to, one or more solid carriers or fillers or diluents. According to another embodiment, the carrier includes a mineral carrier, a plant carrier, a synthetic carrier, a water-soluble carrier. However, those skilled in the art will recognize that different carriers may be used without departing from the scope of the present invention. The carrier is commercially manufactured and available from different companies.

[0085] Solid carriers include natural minerals such as clays, such as china clay, acid clay, kaolinite, dickite, nacrite and halloysite, serpentines, such as chrysotile, serpentine, antigorite and calcium sulfate, synthetic silica and diatomaceous earth, montmorillonite minerals, such as sodium montmorillonite, montmorillonites, such as saponite, hectorite, sauconite and hydromontmorillonite, micas, such as pyrophyllite, talc, boulder, muscovite, polysilicon muscovite, sericite and illite, silica, such as cristobalite and quartz, such as attapulgite and sepiolite; vermiculite, synthetic hectorite, pumice, bauxite, hydrated alumina, perlite, sodium bicarbonate, volcanic clay, vermiculite, limestone, natural and synthetic silicates, charcoal, silicon dioxide, wet silicon dioxide, dry silicon dioxide, calcined products of wet silicon dioxide, surface-modified silicon dioxide, mica, zeolite, diatomaceous earth and its derivatives; chalk Fuller's earth, loess, thenardite, white carbon, slaked lime, synthetic silicic acid, starch, modified starch (Pineflow from Matsutani Chemical Industry Co., Ltd.), cellulose, plant carriers (e.g., cellulose, rice husks, wheat flour, wood flour, starch, rice bran, wheat bran, and soybean flour), tobacco powder, plant powders, polyethylene, polypropylene, poly(vinylidene chloride), sodium caseinate, sucrose, thenardite, potassium pyrophosphate, sodium tripolyphosphate, maleic acid, fumaric acid, and malic acid, or derivatives or mixtures thereof. Commercially available silicates include Aerosil brand, Sipemat brand (e.g., 50S and CALFLO E) and kaolin 1777. However, those skilled in the art will appreciate that different solid supports may be used without departing from the scope of the present invention. Solid supports are commercially manufactured and available from different companies.

[0086] According to an embodiment, the pigments and colorants are selected from, but not limited to, synthetic chemicals from various manufacturers. The pigments and colorants can be water-soluble or water-insoluble, in the form of lakes. The dye can be a solvent dye, an acid dye, or a basic dye. Examples of such products include, but are not limited to, Agrocer Red 112, Agrocer Blue 153, AgrocerGreen 007, Agrocer Yellow 001, Agrocer violet 023, Unisperse black 0058, Unisperse Red 3855, Pigmosol Agro Red 3785.

[0087] According to one embodiment, defoamers or defoamers for agricultural compositions include, but are not limited to, one or more of the following: silicon dioxide, siloxane, silicon dioxide, polydimethylsiloxane, alkyl polyacrylate, ethylene oxide / propylene oxide copolymer, polyethylene glycol, silicone oil, and magnesium stearate or its derivatives. Preferred defoamers include silicone emulsions (e.g., from Solvay SRE, Wacker, or ), long chain alcohols, fatty acids, fluorinated organic compounds. However, those skilled in the art will recognize that other conventionally known defoamers may be used without departing from the scope of the present invention. These defoamers are commercially manufactured and available from different companies.

[0088] According to one embodiment, the pH regulator or buffer or neutralizer used in the agricultural composition includes organic or inorganic type acids and bases and mixtures thereof. According to a further embodiment, the pH regulator or buffer or neutralizer includes but is not limited to one or more of organic acids, inorganic acids and alkali metal compounds or salts, derivatives. According to one embodiment, organic acids include but are not limited to citric acid, malic acid, adipic acid, fumaric acid, maleic acid, succinic acid and tartaric acid, or salts, derivatives thereof; and one or more of the monosalts, disalts or trisalts of these acids or their derivatives. Alkali metal compounds include but are not limited to one or more of alkali metal hydroxides (such as sodium hydroxide and potassium hydroxide), alkali metal carbonates (such as sodium carbonate), alkali metal bicarbonates (such as sodium bicarbonate) and alkali metal phosphates (such as sodium phosphate) and mixtures thereof. According to one embodiment, inorganic acid salts include but are not limited to one or more alkali metal salts, such as lithium chloride, sodium chloride, potassium chloride, sodium nitrate, potassium nitrate, sodium sulfate, potassium sulfate, sodium monohydrogen phosphate, potassium monohydrogen phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, etc. Mixtures can also be used to produce pH regulators or buffers or neutralizers. However, those skilled in the art will appreciate that other conventionally known pH adjusters or buffers or neutralizers may be used without departing from the scope of the present invention. pH adjusters or buffers or neutralizers are commercially manufactured and available through different companies.

[0089] According to one embodiment, the diffusing agent used in the agricultural composition includes, but is not limited to, one or more of the following: cellulose powder, dextrin, modified starch, cross-linked polyvinyl pyrrolidone, copolymers of maleic acid and styrene compounds, (meth) acrylic acid copolymers, half esters of polymers composed of polyols and dicarboxylic anhydrides, water-soluble salts of polystyrene sulfonic acid, fatty acids, latex, aliphatic alcohols, vegetable oils (e.g., cottonseed) or inorganic oils, petroleum fractions, modified trisiloxanes, polyethylene glycols, polyethers, inclusion compounds. However, those skilled in the art will appreciate that other conventionally known diffusing agents may be used without departing from the scope of the present invention. The diffusing agent is commercially manufactured and available from different companies.

[0090] According to one embodiment, the adhesive for the agricultural composition includes, but is not limited to, one or more of the following: paraffin wax, polyamide resin, polyacrylate, polyoxyethylene, wax, polyvinyl alkyl ether, alkylphenol-formaldehyde condensate, fatty acid, latex, aliphatic alcohol, vegetable oil (e.g., cottonseed) or inorganic oil, petroleum fraction, modified trisiloxane, polyethylene glycol, polyether, inclusion compound, synthetic resin emulsion. However, it will be appreciated by those skilled in the art that other conventionally known adhesives may be used without departing from the scope of the present invention. Adhesives are commercially manufactured and available from different companies.

[0091] According to one embodiment, the stabilizer used in the agricultural composition includes, but is not limited to, one or more of the following: peroxide compounds, such as hydrogen peroxide and organic peroxides, alkyl nitrites, such as ethyl nitrite and alkyl glyoxylates, such as ethyl glyoxylate, zeolites, antioxidants, such as phenolic compounds, phosphoric acid compounds, EDTA, sodium sulfite, citric acid, citrates, etc. However, it will be appreciated by those skilled in the art that other conventionally known stabilizers may be used without departing from the scope of the present invention. Stabilizers are commercially manufactured and available from different companies.

[0092] According to one embodiment, the preservative used in the agricultural composition includes, but is not limited to, one or more of bactericides, antifungal agents, biocides, antimicrobial agents, and antioxidants. Non-limiting examples of preservatives include one or more of the following: parabens, esters and salts thereof, propionic acid and its salts, 2,4-hexadienoic acid (sorbic acid) and its salts, formaldehyde and polyformaldehyde, 2-hydroxydiphenyl ether and its salts, inorganic sulfites and bisulfites, sodium iodate, chlorobutanol, glyoxylic acid, formic acid, 1,6-bis (4-amidino-2-bromophenoxy) -n-hexane and its salts, 5-amino-1,3-bis (2-ethylhexyl)) -5-methylhexahydropyrimidine, 5-bromo-5-nitro-1,3-dioxane, 2-bromo-2-nitropropane-1,3-diol, 2,4-dichlorobenzyl alcohol, N- (4-chlorophenyl) -N'- (3,4-dichlorophenyl) urea, 4-chloro-methanesulfonate ...chlorophenyl) -2-bromophenoxy) -n-hexane and its salts, 1,6-bis (4-amidino-2-bromophenoxy) -n- Cresol, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 4-chloro-3,5-dimethylphenol, 1,1'-methylene-bis(3-(1-hydroxymethyl-2,4-di-oximidazolidin-5-yl)urea), polyhexamethylene biguanide hydrochloride, 2-phenoxyethanol, hexamethylenetetramine, 1-(3-chloroallyl)-3,5,7-triaza-1-nitro-adamantane chloride, 1(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanone, l,3-bis(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione, benzyl alcohol, octopirox, l,2-dibromo-2,4-dicyanobutane, 2,2'-methylene Bis(6-bromo-4-chlorophenol), bromochlorophenol, dichlorophenol, 2-benzyl-4-chlorophenol, 2-chloroacetamide, chlorhexidine, chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride, 1-phenoxypropane-2-ol, N-alkyl(C12-C22)trimethylammonium bromide and ammonium chloride, 4,4-dimethyl-1,3-oxazolidine, N-hydroxymethyl-N-(1,3-bis(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)-N'-hydroxymethylurea, 1,6-bis(4-amidinophenoxy)-n-hexane and its salts, glutaraldehyde, 5-ethyl-1-aza-3,7-dioxabicyclo(3.3.0)octane, 3-(4-chlorophenoxy)propane-1,2-dioxadiazole alcohol, hydramine, alkyl (C8-C18) dimethylbenzylammonium chloride, alkyl (C8-C18) dimethylbenzylammonium bromide, alkyl (C8-C18) dimethylbenzylammonium saccharinate, benzyl hemiformal, 3-iodo-2-propynylbutylcarbamate, sodium hydroxymethylaminoacetate, cetyltrimethylammonium bromide, cetylpyridinium chloride, and derivatives of 2H-isothiazol-3-one (so-called isothiazolone derivatives), such as alkylisothiazolinone (e.g. 2-methyl-2H-isothiazol-3-one, MIT; chloro-2-methyl-2H-isothiazol-3-one, CIT), benzisothiazolinone (e.g. 1,2-benzisothiazol-3(2H)-one, BIT, with Type commercially available from ArchBiocides Ltd.) or 2-methyl-4,5-trimethylene-2H-isothiazol-3-one (MTIT), p-hydroxybenzoic acid C1-C4-alkyl esters, dichlorophenol, or from ThorChemie RS and from Lanxess MK, Bacto-100, Thimerosal, Sodium Propionate, Sodium Benzoate, Propyl Paraben, Sodium Propyl Paraben, Potassium Sorbate, Potassium Benzoate, Phenylmercuric Nitrate, Phenylethyl Alcohol, Sodium, Ethyl Paraben, Methyl Paraben, Butyl Paraben, Benzyl Alcohol, Benzethonium Chloride, Cetylpyridinium Chloride, Benzalkonium Chloride, 1,2-Benzothiazol-3-one, Potassium sorbate, iodine-containing organic compounds such as 3-bromo-2,3-diiodo-2-propenyl ethyl carbonate, 3-iodo-2-propynyl butyl carbamate, 2,3,3-triiodoallyl alcohol and p-chlorophenyl-3-iodopropargyl formal; benzimidazole compounds and benzothiazole compounds, such as 2-(4-thiazolyl)benzimidazole and 2-thiocyanatomethylthiobenzothiazole; triazole compounds, such as 1-(2-(2',4'-dichlorophenyl)-1,3- dioxolan-2-ylmethyl)-1H-1,2,4-triazole, 1-(2-(2',4'-dichlorophenyl)-4-propyl-1,3-dioxolan-2-ylmethyl)-1H-1,2,4-triazole and α-(2-(4-chlorophenyl)ethyl)-a-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol; and naturally occurring compounds such as 4-isopropyltropolone (hinokitiol) and borax.Antioxidants include, but are not limited to, imidazole and imidazole derivatives (e.g., urocanic acid), one or more of 4,4'-thiobis-6-tert-butyl-3-methylphenol, 2,6-di-tert-butyl-p-cresol (BHT), pentaerythritol tetrakis[3-(3,5,-di-tert-butyl-4-hydroxyphenyl)]propionate; amine antioxidants, such as N,N'-di-2-naphthyl-p-phenylenediamine; hydroquinoline antioxidants, such as 2,5-di(tert-amyl)hydroquinoline; phosphorus-containing antioxidants such as triphenyl phosphate, carotenoids, carotenes (e.g., α-carotene, β-carotene, lycopene) and their derivatives, lipoic acid and its derivatives derivatives (e.g., dihydrolipoic acid), aurothioglucose, propylthiouracil and other thio compounds (e.g., thioglycerol, thiosorbitol, thioglycolic acid, thioredoxin, their N-acetyl esters, methyl esters, ethyl esters, propyl esters, amyl esters, butyl esters, lauryl esters, palmitoyl esters, oleoyl esters, γ-linoleoyl esters, cholesterol esters and glycerides) and their salts, dilaurylthiodipropionate, distearylthiodipropionate, thiodipropionic acid and its derivatives (esters, ethers, lipids, nucleotides, nucleosides and salts) and sulfoximine compounds (e.g., buthionine sulfoximine, homocysteine ​​sulfoximine, buthionine sulfone, Penta-, hexa-, heptathionine sulfoximine) tolerated at very low doses (e.g., pmol / kg to pmol / kg), alpha-hydroxy acids (e.g., citric acid, lactic acid, malic acid), humic acid, gallic acid esters (e.g., propyl, octyl and dodecyl gallate), unsaturated fatty acids and their derivatives, hydroquinone and its derivatives (e.g., arbutin), ubiquinone and ubiquinol and their derivatives, ascorbyl palmitate, stearate, dipalmitate, acetate, magnesium ascorbyl phosphate, diascorbyl phosphate and sulfate, potassium ascorbyl tocopheryl phosphate, isoascorbic acid and its derivatives, coniferyl benzoate of benzoin resin, ascorbyl sulfate, Butyl, rutin acid and derivatives thereof, rutin sulfate disodium, butylated hydroxytoluene, 4,4-thiobis-6-tert-butyl-3-methylphenol, butylated hydroxyanisole, p-octylphenol, single (two or three) methylbenzylphenol, 2,6-tert-butyl-4-methylphenol, pentaerythritol tetra-3-(3,5-di-tert-butyl-4-hydroxyphenyl) propionate, butylated hydroxyanisole, nordihydroguaiaretic acid, nordihydroguaiaretic acid, trihydroxybutyrophenone, uric acid and derivatives thereof, mannose and derivatives thereof, selenium and selenium derivatives (such as selenomethionine), stilbenes and stilbenes derivatives (such as stilbenes oxide, trans-stilbenes oxide). However, those skilled in the art will recognize that, without departing from the scope of the invention, other conventional known preservatives can be used. These preservatives are commercially manufactured and can be obtained by different companies.

[0093] According to one embodiment, the structurant used in the pesticide composition includes, but is not limited to, one or more of a thickener, a viscosity modifier, a tackifier, a suspension aid, a rheology modifier, or an anti-settling agent. The structurant can prevent the active ingredient granules from settling after long-term storage.

[0094] According to one embodiment, the structurant for the aqueous suspension composition includes, but is not limited to, one or more of the following: polymers, such as polyacrylic acids, polyacrylamides, polysaccharides, hydrophobically modified cellulose derivatives, copolymers of cellulose derivatives, carboxyvinyl or polyvinyl pyrrolidone, polyethylene, polyethylene oxide, polyvinyl alcohol and its derivatives; clays such as bentonite, kaolin, montmorillonite, attapulgite, clays with high surface area silica and natural gums such as guar gum, xanthan gum, gum arabic, tragacanth gum, rhamn gum, locust bean gum, carrageenan, welan gum, aluminum silicate, gelatin, dextrin, collagen; polyacrylic acid and its sodium salt; condensation products of polyethylene glycol ethers of fatty alcohols and polyethylene oxide or polypropylene oxide and mixtures thereof, including The invention also includes ethoxylated alkylphenols (also known in the art as alkylaryl polyether alcohols); ethoxylated fatty alcohols (or alkyl polyether alcohols); ethoxylated fatty acids (or polyoxyethylene fatty acid esters); ethoxylated sorbitan esters (or polyethylene sorbitan fatty acid esters), long-chain amines and cyclic amine oxides, which are non-ionic in alkaline solutions; long-chain tertiary phosphine oxides; and long-chain dialkyl sulfoxides, fumed silica, mixtures of fumed silica and fumed alumina, swellable polymers, polyamides or derivatives thereof; polyols such as glycerol, poly(vinyl acetate), sodium polyacrylate, poly(ethylene glycol), phospholipids (such as cephalin, etc.); stachyose, oligofructose, amylose, pectin, alginate, hydrocolloids and mixtures thereof. There are also celluloses, such as hemicellulose, carboxymethyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxymethyl ethyl cellulose, hydroxyethyl propyl cellulose, methyl hydroxyethyl cellulose, methyl cellulose; starches, such as starch acetate, starch hydroxyethyl ether, ionic starch, long-chain alkyl starch, dextrin, maltodextrin, corn starch, amine starch, phosphate starch and dialdehyde starch; plant starches, such as corn starch and potato starch; other carbohydrates, such as pectin, dextrin, amylopectin, xylan, glycogen, agar, gluten, alginic acid, algin or its derivatives. However, those skilled in the art will understand that other conventionally known structurants can be utilized without departing from the scope of the present invention.

[0095] Preferred structurants include one or more of xanthan gum, guar gum, aluminum silicate, methylcellulose and its derivatives, polysaccharides, alkaline earth metal silicates and polyvinyl alcohol. Structurants are commercially manufactured and available from various companies.

[0096] According to one embodiment, the anti-caking agent or anti-settling agent or suspending agent used includes but is not limited to one or more of the following: polysaccharides, such as bentonite, starch, mannose, galactose, cellulose derivatives, such as sodium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl cellulose; gums, such as agar, carrageenan, alginate, gum arabic, tragacanth gum, karaya gum, ghatti gum, guar gum, dextran, starch (including pregelatinized starch and modified starch), polyvinyl pyrrolidone, fumed silica (white carbon black), ester gum, petroleum resin, SoapL sodium stearate, sodium acetate, sodium metasilicate, sodium alkyl sulfosuccinate, salts or derivatives thereof. However, it will be appreciated by those skilled in the art that different anti-caking agents may be used without departing from the scope of the present invention. Anti-caking agents or anti-settling agents or suspending agents or suspending aids are commercially manufactured and available from different companies.

[0097] According to one embodiment, the antifreeze or freezing point depressant used in the aqueous suspension composition includes but is not limited to one or more of the following: polyols, such as ethylene glycol, diethylene glycol, dipropylene glycol, propylene glycol, butyrolactone, N, N-dimethylformamide, glycerine, monohydric alcohol or polyol, glycol ether, glycol ether, glycol monoether such as methyl, ethyl, propyl and butyl ether of ethylene glycol, diethylene glycol, propylene glycol and dipropylene glycol, glycol diether, such as methyl and ethyl diether of ethylene glycol, diethylene glycol and dipropylene glycol. Or urea, glycerine, isopropanol, propylene glycol monomethyl ester ether, dipropylene glycol monomethyl ether or tripropylene glycol monomethyl ether or cyclohexanol, carbohydrates such as glucose, mannose, fructose, galactose, sucrose, lactose, maltose, xylose, arabinose, sorbitol, mannitol, trehalose, raffinose or its derivatives. However, those skilled in the art will appreciate that different antifreeze agents may be used without departing from the scope of the present invention. According to one embodiment, the antifreeze agent is present in an amount of 0.1% to 20% w / w of the total composition.

[0098] According to one embodiment, the penetrant used in the composition includes, but is not limited to, one or more of the following: alcohol, glycol, glycol ether, ester, amine, alkanolamine, amine oxide, quaternary ammonium compound, triglyceride, fatty acid ester, fatty acid ether, N-methylpyrrolidone, dimethylformamide, dimethylacetamide or dimethyl sulfoxide, polyoxyethylene trimethylolpropane monooleate, polyoxyethylene trimethylolpropane dioleate, polyoxyethylene trimethylolpropane trioleate, polyoxyethylene sorbitan monooleate, polyoxyethylene trisiloxane, sorbitol hexaoleate. However, those skilled in the art will appreciate that different penetrants may be used without departing from the scope of the present invention.

[0099] According to one embodiment, the ultraviolet absorber is selected from but not limited to one or more of the following: 2-(2'-hydroxy-5'-methylphenyl)benzotriazole, 2-ethoxy-2'-ethyloxazole acid diphenylamine, succinic acid dimethyl-1-(2-hydroxyethyl)-4-hydroxy-2,2,6,6-tetramethylpiperidinium condensate, benzotriazole compounds, such as 2-(2'-hydroxy-5'-methylphenyl)benzotriazole, 2-(2'-hydroxy)-4'-octyl succinate. oxyphenyl); benzophenone compounds, such as 2-hydroxy-4-methoxybenzophenone and 2-hydroxy-4-n-octyloxybenzophenone; salicylic acid compounds, such as phenyl salicylate, p-tert-butylphenyl salicylate; 2-ethylhexyl 2-cyano-3,3-diphenylacrylate, 2-ethoxy-2'-ethyl oxalic acid diphenylamine and dimethyl succinate-1-(2-hydroxyethyl)-4-hydroxy-2,2,6,6-tetramethylpiperidine condensation products or derivatives, etc. However, it will be appreciated by those skilled in the art that different UV absorbers may be used without departing from the scope of the present invention. Such UV absorbers are commercially manufactured and can be obtained through different companies.

[0100] According to one embodiment, the UV scattering agent that can be used includes but is not limited to titanium dioxide, etc. However, those skilled in the art will understand that different UV scattering agents or mixtures thereof can be used without departing from the scope of the present invention. Such UV scattering agents are commercially manufactured and can be obtained from different companies.

[0101] According to one embodiment, the moisturizer is selected from but not limited to one or more of the following: polyoxyethylene / polyoxypropylene copolymers, in particular block copolymers, such as Synperonic PE series copolymers available from Uniqema or salts or derivatives thereof. Other moisturizers are propylene glycol, monoethylene glycol, hexylene glycol, butylene glycol, ethylene glycol, diethylene glycol, poly(ethylene glycol), poly(propylene glycol), glycerol, etc.; polyols or derivatives thereof. In addition, other moisturizers include aloe vera gel, alpha hydroxy acids (e.g., lactic acid and its salts), albumin, triacetin, honey, calcium chloride, etc. The above-mentioned nonionic surfactants are also used as moisturizers. However, those skilled in the art will appreciate that other conventionally known moisturizers may be used without departing from the scope of the present invention. Moisturizers are commercially manufactured and available from different companies.

[0102] According to one embodiment, the pesticide composition may include at least one other active ingredient. According to one embodiment, the active ingredient may include at least one pesticide active substance, fertilizer, micronutrient, macronutrient, organic acid or mixture thereof. According to further embodiments, the pesticide active ingredient may be one or more of pesticide, fungicide, pesticide, acaricide, acaricide, nematicide, pheromone, plant growth regulator, etc. However, it will be appreciated by those skilled in the art that other further active ingredients may be used without departing from the scope of the present invention.

[0103] According to further embodiments, the further active ingredient may be present in a concentration range of 0.1% w / w to 80% w / w of the total composition. According to further embodiments, the active ingredient may be present in a concentration range of 0.1% w / w to 70% w / w of the total composition. According to further embodiments, the active ingredient may be present in a concentration range of 0.1% w / w to 50% w / w of the total composition. According to further embodiments, the active ingredient may be present in a concentration range of 0.1% w / w to 30% w / w of the total composition. According to further embodiments, the active ingredient may be present in a concentration range of 0.1% w / w to 10% w / w of the total composition.

[0104] It has surprisingly been found that the pesticide compositions of the present invention have enhanced and improved physical properties of dispersibility, suspensibility, wettability, viscosity, pourability, storage stability, are easy to handle, and also reduce material losses when handling the product during packaging and during field application.

[0105] Wettability is a wettable condition or state, defined as the degree to which a solid is wetted by a liquid, measured by the adhesion forces between the solid and liquid phases. The wettability of granular compositions is measured using the standard CIPAC test MT-53, which describes a procedure for determining the time to complete wetting of a wettable formulation. A weighed amount of the granular composition is dropped from a specified height onto water in a beaker, and the time to complete wetting is determined. According to another embodiment, the wettability of the pesticide composition in the form of water-dispersible granules or spherical granules is less than 2 minutes. According to another embodiment, the wettability of the pesticide composition is less than 1 minute. According to another embodiment, the wettability of the pesticide composition is less than 30 seconds. According to another embodiment, the wettability of the pesticide composition is less than 15 seconds.

[0106] The spheronized granule composition is formulated in such a way that it has sufficient hardness to prevent the granules from breaking during storage and transportation. The granule composition is formulated in such a way that it has sufficient hardness to prevent the granules from breaking during storage and transportation. The hardness exhibited by the granules is estimated by a hardness meter, such as those provided by Monsanto, Sotax, Erweka, Agilent, Vinsyst, Dr. Schleuniger, which is based on pharmacopoeias (e.g., U.S. Pharmacopeia No. <1217> According to one embodiment, the granules exhibit a hardness of less than 100 Newtons.

[0107] Abrasion resistance determines the wear resistance of the granule material. The water-disintegrable granule composition has good abrasion resistance. The sample can be subjected to abrasion testing according to the test "MT 178.2-Abrasion resistance of granules" specified in the CIPAC manual. According to one embodiment, the abrasion resistance of the water-dispersible granule composition is at least 50%.

[0108] According to one embodiment, the pesticide composition in the form of a water dispersible granule or a liquid suspension is tested by wet sieve retention. This test is used to determine the amount of non-dispersible material in a formulation applied as a dispersion in water. The wet sieve retention value of agrochemical compositions in the form of liquid suspensions and granules is measured using the standard CIPAC test MT-185, which describes a procedure for measuring the amount of material retained on a sieve. A sample of the formulation is dispersed in water, the resulting suspension is transferred to a sieve and washed. The amount of material retained on the sieve is determined by drying and weighing.

[0109] According to one embodiment, the pesticide composition in the form of water-dispersible granules or liquid suspension has a wet sieve retention value on a 75 micron sieve of less than 0.5%. According to one embodiment, the pesticide composition has a wet sieve retention value on a 75 micron sieve of less than 0.2%. According to one embodiment, the pesticide composition has a wet sieve retention value on a 75 micron sieve of less than 0.1%. A wet sieve retention value of less than 0.5% indicates that the pesticide composition facilitates easy application of the formulation and prevents clogging of nozzles or filtering equipment.

[0110] According to one embodiment, the pesticide composition in the form of a liquid suspension does not settle or sediment when stored and is easy to pour. This property is measured in terms of the viscosity of a fluid, which is a measure of its resistance to gradual deformation under shear or tensile stress.

[0111] According to one embodiment, the viscosity of the liquid composition is determined according to CIPAC MT-192. The sample is transferred to a standard measuring system. The measurement is performed under different shear conditions and the apparent viscosity is determined. During the test, the temperature of the liquid is kept constant.

[0112] According to one embodiment, the viscosity of the pesticide composition at 20°C is about 10cps to about 3000cps. According to one embodiment, the viscosity of the pesticide composition at 20°C is about 10cps to about 2500cps. According to one embodiment, the viscosity of the pesticide composition at 20°C is about 10cps to about 2000cps. According to one embodiment, the viscosity of the pesticide composition at 20°C is about 10cps to about 1500cps. According to one embodiment, the viscosity of the pesticide composition at 20°C is about 10cps to about 1200cps. According to one embodiment, the viscosity of the pesticide composition at 20°C is about 10cps to about 500cps. According to one embodiment, the viscosity of the pesticide composition at 20°C is about less than 500cps. According to one embodiment, the viscosity of the pesticide composition at 20°C is about 10cps to about 400cps. According to one embodiment, the viscosity of the pesticide composition at 20°C is about 10cps to about 300cps.

[0113] According to one embodiment, the liquid suspension composition of the present invention is easy to pour. Pourability is a measure of the percentage of residue.

[0114] According to one embodiment, the pourability of the pesticide composition is determined according to CIPAC MT-148.1 by allowing the liquid suspension to stand for 24 hours and determining the amount remaining in the container after a standardized pouring procedure. The container is rinsed and the remaining amount is determined and the maximum residual percentage is calculated. According to another embodiment, the pourability of the pesticide composition is less than 5% residual. According to another embodiment, the pourability of the pesticide composition is preferably less than 2.5% residual. According to another embodiment, the pourability of the pesticide composition is more preferably less than 2.0% residual.

[0115] The dispersibility of a pesticide composition in the form of a water-dispersible or spheronized granule is a measure of the percent dispersibility. The dispersibility is calculated by the minimum percent dispersibility. Dispersibility is defined as the ability of a granule to disperse after the addition of a liquid (e.g. water or a solvent). The dispersibility of the granule composition of the present application is determined according to the standard CIPAC test MT 174. A known amount of the granule composition is added to a certain volume of water and stirred to mix to form a suspension. After standing for a short period of time, the top nine-tenths are removed, the remaining tenth is dried and measured gravimetrically. This method is actually a shortened suspension test and is suitable for determining the ease with which a granule composition can be uniformly dispersed in water.

[0116] According to one embodiment, the pesticide composition has a dispersibility of at least 30%. According to one embodiment, the pesticide composition has a dispersibility of at least 40%. According to one embodiment, the pesticide composition has a dispersibility of at least 50%. According to one embodiment, the pesticide composition has a dispersibility of at least 60%. According to one embodiment, the pesticide composition has a dispersibility of at least 70%. According to one embodiment, the pesticide composition has a dispersibility of at least 80%. According to one embodiment, the pesticide composition has a dispersibility of at least 90%. According to one embodiment, the pesticide composition has a dispersibility of at least 99%. According to one embodiment, the pesticide composition has a dispersibility of 100%.

[0117] According to one embodiment, the pesticide composition in the form of water-dispersible granules can be dispersed almost instantly.

[0118] According to one embodiment, the pesticide composition in the form of spheronized granules makes the active substance instantly available and available over a longer period of time that can extend throughout the crop cycle, thereby providing immediate and sustained release of the active ingredient, ultimately enhancing and protecting the crop at every stage of the crop cycle.

[0119] According to one embodiment, the pesticide composition in the form of water-dispersible granules, liquid suspensions, has good suspensibility. Suspensibility is defined as the amount of active ingredient after being suspended for a certain period of time in a liquid column of a specified height, expressed as a percentage of the amount of active ingredient in the original suspension. The suspensibility test of water-dispersible granules is carried out according to the CIPAC manual "MT 184 Suspensibility Test", in which a suspension of the composition in CIPAC standard water of known concentration is prepared and placed in a measuring cylinder at a specified temperature and left undisturbed for a specified time. The top 9 / 10 is drawn off, and the remaining 1 / 10 is then analyzed chemically, gravimetrically or by solvent extraction, and the suspensibility is calculated.

[0120] The suspendability of a liquid suspension is the amount of active ingredient suspended in a column of liquid of a specified height after a given time, expressed as a percentage of the amount of active ingredient in the original suspension. The suspendability of a liquid suspension concentrate is determined in accordance with CIPAC MT-161 by preparing 250 ml of the dilute suspension, allowing it to stand in a graduated cylinder under specified conditions, and removing the top nine-tenths. The remaining tenth is then analyzed chemically, gravimetrically, or by solvent extraction, and the suspendability is calculated.

[0121] According to one embodiment, the pesticide composition has a suspensibility of at least 30%. According to one embodiment, the pesticide composition has a suspensibility of at least 40%. According to one embodiment, the pesticide composition has a suspensibility of at least 50%. According to one embodiment, the pesticide composition has a suspensibility of at least 60%. According to one embodiment, the pesticide composition has a suspensibility of at least 70%. According to one embodiment, the pesticide composition has a suspensibility of at least 80%. According to one embodiment, the pesticide composition has a suspensibility of at least 90%. According to one embodiment, the pesticide composition has a suspensibility of at least 99%. According to one embodiment, the pesticide composition has a suspensibility of 100%.

[0122] According to one embodiment, the pesticide composition is in the form of water-dispersible granules or spherical granules, or a liquid suspension, and exhibits excellent suspension stability under accelerated storage conditions (ATS). According to one embodiment, the pesticide composition exhibits more than 90% suspension under ATS. According to one embodiment, the pesticide composition exhibits more than 80% suspension under ATS. According to one embodiment, the pesticide composition exhibits more than 70% suspension under ATS. According to one embodiment, the pesticide composition exhibits more than 60% suspension under ATS. According to one embodiment, the pesticide composition exhibits more than 50% suspension under ATS. According to one embodiment, the pesticide composition exhibits more than 40% suspension under ATS. According to one embodiment, the pesticide composition exhibits more than 30% suspension under ATS.

[0123] According to one embodiment, the pesticide composition exhibits a dispersibility greater than 90% under ATS. According to one embodiment, the pesticide composition exhibits a dispersibility greater than 80% under ATS. According to one embodiment, the pesticide composition exhibits a dispersibility greater than 70% under ATS. According to one embodiment, the pesticide composition exhibits a dispersibility greater than 60% under ATS. According to one embodiment, the pesticide composition exhibits a dispersibility greater than 50% under ATS. According to one embodiment, the pesticide composition exhibits a dispersibility greater than 40% under ATS. According to one embodiment, the pesticide composition exhibits a dispersibility greater than 30% under ATS.

[0124] According to one embodiment, the pesticide composition exhibits excellent stability to heat, light, temperature and caking. The composition does not form a hard cake and exhibits enhanced stability even for long-term storage at higher temperatures, resulting in excellent field performance. According to further embodiments, the pesticide composition exhibits stability of at least 3 years. According to further embodiments, the pesticide composition exhibits stability of at least 2 years. According to further embodiments, the pesticide composition exhibits stability of at least 1 year. According to further embodiments, the pesticide composition exhibits stability of at least 6 months.

[0125] According to one embodiment, the present invention relates to a method for preparing a pesticide composition of the present invention, which comprises: 0.1% w / w to 20% w / w of trifluoropyrimidine in the total composition; 1% w / w to 50% w / w of tebuconazole in the total composition; 10% w / w to 70% w / w of tricyclazole in the total composition; and at least one agrochemically acceptable excipient.

[0126] According to another embodiment, the present invention relates to a method for preparing a pesticide composition in the form of water dispersible granules, spheronized granules, liquid suspensions, wettable powders, suspoemulsions, water dispersible powders for seed coating (WS) and suspension concentrates for seed coating (FS).

[0127] According to further embodiments, the pesticide composition in the form of water-dispersible granules or spheronized granules is prepared by various techniques, such as spray drying, fluidized bed granulation, disk granulation, pan granulation, pin agglomerator, spheronizer, freeze drying or a combination. The granules can also be extruded by an extruder to obtain extruded granules.

[0128] The present invention also relates to a method for preparing a pesticide composition in the form of water-dispersible granules, which comprises: a) grinding and blending trifluridine, tebuconazole and tricyclazole with at least one agrochemical excipient to obtain a slurry or a wet mixture, wherein the size of the microparticles ranges from 0.1 to 50 microns, and b) drying the wet mixture, sieving the dried mixture to remove undersized and oversized granules to obtain water-dispersible granules; wherein the granules of the composition consist of granules with a size range of 0.025 mm to 3 mm.

[0129] The present invention also relates to a method for preparing a pesticide composition in the form of granules, the method comprising:

[0130] a) grinding and blending trifluridine, tebuconazole and tricyclazole with at least one agrochemical excipient to obtain a slurry or wet mixture, wherein the size of the microparticles ranges from 0.1 to 75 microns;

[0131] b) drying the wet mixture to obtain a dry mixture; and

[0132] c) adding water to the dry mixture and mixing to obtain a dough or paste, and extruding through an extruder to obtain extruded granules having a size ranging from 0.025 mm to 6 mm; or

[0133] The wet mix or dry mix obtained in step (b) is agglomerated in an agglomerator to obtain a spheronized granule composition having a size ranging from 0.025 mm to 6 mm.

[0134] The wet mixture obtained is dried, for example in a spray dryer, fluidized bed dryer or any suitable granulation equipment, and then sieved to remove undersized and oversized granules to obtain granules.

[0135] The present invention relates to a method for preparing a wettable powder (WP) or "wettable powder for seed coat (WS)" composition, wherein the method involves mixing an effective amount of trifluoropyrimidine with a desired diluent and inert ingredients to obtain a first mixture. The method involves mixing an effective amount of tebuconazole with a desired diluent and inert ingredients to obtain a second mixture. Tricyclazole is then mixed with a surfactant to obtain a third mixture. The three mixtures are then mixed for 30 minutes using a suitable mass mixer and passed through a jet mill to obtain a wettable powder composition having a desired particle size range of 0.1 microns to 75 microns. Alternatively, the wettable powder composition is prepared by mixing an effective amount of trifluoropyrimidine, tebuconazole and tricyclazole with a desired diluent and inert ingredients using a suitable mass mixer for 30 minutes and then passing through a jet mill to obtain a wettable powder composition having a desired particle size range of 0.1 microns to 75 microns.

[0136] The present invention relates to a method for preparing a liquid suspension or "suspension concentrate (FS) for seed treatment" composition, which comprises: homogenizing a trifluoropyrimidine mixture of 0.1% w / w to 20% w / w of the total composition, a tebuconazole mixture of 1% w / w to 50% w / w of the total composition, a tricyclazole mixture of 10% w / w to 70% w / w of the total composition and at least one agrochemically acceptable excipient to obtain a suspension; and wet-milling the obtained suspension to provide a composition having a particle size ranging from 0.1 micron to 75 microns.

[0137] The method for preparing a liquid suspension comprises feeding one or more excipients into a container equipped with a stirring device to homogenize them. Trifluridine, tebuconazole and tricyclazole are added to the homogenized mixture and stirred continuously for about 5 to 10 minutes until the total mixture becomes uniform. Subsequently, the obtained suspension is passed through a wet grinder to obtain the desired particle size in the range of 0.1 to 75 microns. Then, under continuous homogenization, the required amount of structurant is added to the obtained suspension. However, it will be appreciated by those skilled in the art that the process or process parameters may be modified or changed to obtain a liquid suspension composition without departing from the scope of the present invention.

[0138] The present invention relates to a method for preparing a suspension emulsion pesticide composition, which comprises: dissolving a wetting agent and a dispersant in water to obtain a mixture, then adding a moisturizer, a defoamer, and if necessary, trifluoropyrimidine and tricyclazole to obtain a homogenous suspension, and further grinding to obtain a desired particle size (first part). Tebuconazole is dissolved in oil or a solvent, and then a surfactant is added to prepare a concentrated emulsion with a desired agrochemical excipient to obtain a second part. The two obtained fractions are then mixed for 30 minutes using a homogenizer to obtain a suspension emulsion composition with a desired particle size of 0.1 to 75 microns.

[0139] According to one embodiment, the composition of the present invention is at least one of a pesticide composition, a crop protection composition, a crop enhancer composition, and a yield enhancer composition.

[0140] According to one embodiment, the present invention also relates to a method for applying the composition.

[0141] According to one embodiment, the present invention also relates to a method for protecting crops, controlling insect pests and diseases, improving crop health and growth, increasing crop yield, and strengthening plants, the method comprising treating at least one of plants, crops, plant propagation materials, sites or parts thereof, seeds, seedlings or surrounding soil with a pesticide composition, the pesticide composition comprising: triflupyrimidine accounting for 0.1% w / w to 20% w / w of the total composition; tebuconazole accounting for 1% w / w to 50% w / w of the total composition; tricyclazole accounting for 10% w / w to 70% w / w of the total composition. The composition can be sprayed directly onto the plant, such as its leaves, or applied to the plant propagation material, or its location, before sowing or planting.

[0142] The composition is applied by a variety of methods. The method of application to the soil includes any suitable method to ensure that the composition penetrates into the soil, such as seedling tray application, furrow application, soil drench, soil injection, drip irrigation, sprinkler irrigation, seed treatment, seed painting and other such methods. The composition is also applied in the form of a foliar spray.

[0143] The application rate or dosage of the composition depends on the type of use, crop variety or composition form, but the amount of the pesticide active ingredient should be effective to provide the desired effect, such as crop protection, crop yield.

[0144] It was observed that the combination of the present invention had a good control effect on various pests and diseases, namely brown planthopper, white-backed planthopper, rice blast, sheath blight, false smut and grain discoloration, compared to the use of the active ingredients alone and the known combinations. In addition, the composition of the present invention not only helps to increase crop yield, but the plants also show enhanced physiological parameters.

[0145] It was observed that the compositions of the present invention, wherein the particle size of the composition is in the range of 0.1 micron to 75 microns, exhibit enhanced, effective and superior behavior in the field at reduced dosages. The pesticide composition having a particle size range of 0.1 micron to 75 microns provides increased surface area coverage when applied to leaves, which enhances adhesion, and provides better penetration of the active ingredient when applied to leaves, and also facilitates better root absorption when applied to the surrounding soil, thereby improving their efficacy and bioavailability. The pesticide composition of triflupyrimidine, tebuconazole and tricyclazole has a particle size range of 0.1 micron to 75 microns, and its dispersibility and suspension are also enhanced, and when applied to the target part of the plant or the surrounding soil, the active ingredient is evenly distributed, thereby allowing the crop to better absorb or absorb the active ingredient, thereby improving the efficacy of the formulation. The particle size of the composition not only provides an effective composition, but also improves the physical properties of the composition.

[0146] Thus, it has been observed that the composition of the present invention exhibits enhanced, effective and superior behavior in the field at reduced dosages.

[0147] From the above, it can be seen that many modifications and variations can be made without departing from the true spirit and scope of the novel concepts of the present invention. It should be understood that no limitation is intended or should be inferred with respect to the specific embodiments shown.

[0148] A. Preparation Example:

[0149] The following examples illustrate the basic method and versatility of the compositions of the present invention. It should be noted that the present invention is not limited to these examples, but rather extrapolates to the overall concentration ranges of the components required.

[0150] Example 1: Water dispersible granule composition of 3.78% trifluridine, 28.17% tebuconazole and 45% tricyclazole

[0151] The water dispersible granules are prepared by mixing and grinding 4 parts of trifluridine technical, 30.3 parts of tebuconazole technical, 48.5 parts of tricyclazole technical, 4 parts of a mixture of naphthalenesulfonate and phenolsulfonic acid condensate, 4 parts of sodium salt of naphthalenesulfonate condensate, 2 parts of sodium lauryl sulfate, 0.2 parts of defoamer, 3 parts of clay and 100 parts of water. The average particle size of the composition is less than 2.5 microns.

[0152] To the mixed milled slurry 4 parts of sodium citrate was added and stirred for one hour and then the material was spray dried / fluid bed dried to obtain the product. The granule size of the composition was less than 1.5 mm.

[0153] RT Results

[0154] Suspensibility: 90%, wet sieve retention value on 75 micron sieve is 0.21%, dispersion: 85%, wetting time is 5 seconds.

[0155] Accelerated Storage Stability Results

[0156] Suspensibility: 85%, wet sieve retention value on 75 micron sieve is 0.25%, dispersibility: 76%, wetting time is 10 seconds.

[0157] Example 2: Water dispersible granule composition of 2.5% trifluridine, 18.8% tebuconazole and 30% tricyclazole

[0158] The water dispersible granules are prepared as follows: 2.75 parts of trifluridine technical drug are mixed with 20.25 parts of tebuconazole technical drug and 32.50 parts of tricyclazole technical drug. 6 parts of the mixture are mixed with naphthalenesulfonate and phenolsulfonic acid condensation product, 5 parts of naphthalenesulfonate condensate sodium salt, 2 parts of sodium lauryl sulfate, 0.2 parts of defoamer, 15 parts of clay in 100 parts of water and ground. The average particle size of the composition is less than 2.5 microns.

[0159] 8 parts of sodium citrate, 8.3 parts of sodium lignin sulfonate were added to the mixed grind pulp, stirred for one hour, and then spray dried / fluidized bed dried to obtain the product. The granule size of the composition was <1.5 mm.

[0160] RT Results

[0161] Suspensibility: 88%, wet sieve retention value on 75 micron sieve is 0.25%, dispersion: 80%, wetting time is 4 seconds.

[0162] Accelerated Storage Stability Results

[0163] Suspensibility: 82%, wet sieve retention value on 75 micron sieve is 0.22%, dispersibility: 72%, wetting time is 8 seconds.

[0164] Example 3: Suspension concentrate composition of 1.7% trifluridine, 12.5% ​​tebuconazole and 20% tricyclazole

[0165] The suspension concentrate composition is prepared as follows: 15 parts of alkylnaphthalene sulfonate condensate and 70 parts of propylene glycol are added to water and sent to a container equipped with a stirring device to homogenize them. 18.35 parts of trifluoropyrimidine industrial products, 132.60 parts of tebuconazole industrial products, and 211.60 parts of tricyclazole industrial products are further added to the homogenized mixture, and stirring is continued for about 10 minutes until the total mixture is homogenized. Under continuous homogenization, 20 parts of tristyrylphenol phosphate and 1 part of polydimethylsiloxane emulsion are added to the above mixture to obtain a liquid suspension. Subsequently, the obtained suspension is passed through a wet mill to reduce the particle size. Then, 1 part of xanthan gum, 1 part of 1,2-benzothiazoline-3-one and 1 part of polydimethylsiloxane emulsion are added under continuous homogenization to obtain a liquid suspension.

[0166] The particle size of the composition is d(10): 0.83 microns, d(50): 2.2 microns and d(90): 4.4 microns, the viscosity is 300 cps, the suspensibility is 91%, the pourability of the rinse residue is 0.4%, the spontaneity of dispersion is 90%, and the retention value of 75 micron wet sieve is 0.02%.

[0167] The composition had a particle size of d(10): 0.86 microns, d(50): 2.6 microns and d(90): 5.2 microns, a viscosity of 350 cps, a suspensibility of 87% under accelerated storage conditions, a pourability of 0.52% in rinse residue, a spontaneity of 86% in dispersion, and a 75 micron wet screen retention of 0.03%.

[0168] Example 4: Suspension concentrate composition of 3.15% trifluridine, 16.65% tebuconazole and 25% tricyclazole

[0169] The suspension concentrate was prepared as follows: 10 parts of alkylnaphthalene sulfonate condensate and 80 parts of propylene glycol were added to water and introduced into a container equipped with a stirring device. 32.65 parts of trifluoropyrimidine technical product, 176.84 parts of tebuconazole technical product, 265.26 parts of tricyclazole technical product were further added to the homogenized mixture and stirred continuously for about 10 minutes until the total mixture was homogenized. In the above mixture, 25 parts of grafted comb polymer, 5 parts of polyalkoxylated butyl ether, 10 parts of ethylene oxide / propylene oxide block polymer mixture, 1 part of polydimethylsiloxane emulsion were added under continuous homogenization to obtain a liquid suspension. Subsequently, the obtained suspension was passed through a wet mill to reduce the particle size. Then, 1.2 parts of xanthan gum, 1 part of 1,2-benzothiazoline-3-one, 0.5 parts of silicon dioxide and 1 part of polydimethylsiloxane emulsion were added under continuous homogenization to obtain a liquid suspension.

[0170] The granule size of the composition was d(10): 0.93 microns, d(50): 2.4 microns and d(90): 4.6 microns, the viscosity was 720 cps, the suspensibility was 89%. The pourability of the rinse residue was found to be 0.6%. The spontaneity of dispersion was 86%, and the retention on a 75 micron wet sieve was 0.03%.

[0171] The composition had a particle size of d(10): 0.97 microns, d(50): 2.8 microns and d(90): 5.6 microns, a viscosity of 830 cps, a suspensibility of 82% under accelerated storage conditions, a pourability of 0.62% in the rinse residue, a spontaneity of 84% in the dispersion, and a 75 micron wet screen retention of 0.08%.

[0172] Example 5: Wettable powder composition of 4.2% trifluridine, 31.3% tebuconazole and 50% tricyclazole

[0173] A wettable powder composition was prepared by mixing 4.2 parts of a technical product of trifluoropyrimidine with 4.85 parts of an alkylnaphthalene sulfonate condensate, 2 parts of sodium lignin sulfonate, 3 parts of sodium lauryl sulfate, 33.15 parts of a technical product of tebuconazole and 52.8 parts of a technical product of tricyclazole in a ribbon mixer, and then jet milling the mixture to obtain a wettable powder composition having a particle size of less than 8 microns.

[0174] RT Results

[0175] The suspension is 65% and the wetting time is 45 seconds.

[0176] Stability results

[0177] The suspension is 60% and the wetting time is 60 seconds.

[0178] Example 6: Extruded granule composition of 1% trifluridine, 5% tebuconazole and 70% tricyclazole

[0179] 1.15 parts of trifluridine technical, 5.5 parts of tebuconazole technical, 73.8 parts of tricyclazole technical, 6 grams of alkylnaphthalene sulfonate condensate, 4 parts of sodium dodecyl sulfate, 4 parts of sulfate lignin polymer, 2 parts of sodium tripolyphosphate, 2 parts of sodium lignin sulfonate, 1.55 parts of clay were mixed in a ribbon mixer to obtain a uniform powder. The mixture was then jet milled to obtain a powder with a particle size of less than 10 microns.

[0180] 15 g of water was added to the above mixture to form a mass, and then the material was squeezed and dried to obtain granules having a mesh size of less than 1.2 mm.

[0181] RT Results

[0182] The suspension is 65% and the wetting time is 5 seconds.

[0183] Stability results

[0184] The suspensibility was 62% and the wetting time was 3 seconds.

[0185] A. Field research:

[0186] Synergy calculation:

[0187] Crop damage to rice crops due to disease was recorded every 15 days after the second application after rice plants were planted, and the percentage of control was calculated using the following formula:

[0188] Control (%) = [(damage of control plot - damage of treated plot) / damage of control plot] × 100

[0189] Average disease control data and rice yield were recorded at harvest and are presented in Tables 1-4.

[0190] "Synergy" is defined by Colby SR in an article entitled "Calculation of synergistic and antagonistic reactions of herbicide combinations" published in Weeds (1967, Vol. 15, pp. 20-22). The expected action of a given combination of two active ingredients is calculated as follows:

[0191] E=X+Y-(XY / 100)

[0192] in,

[0193] E = the expected percentage effect of mixing two products X and Y at a specified dosage,

[0194] X = observed percentage effect of product A,

[0195] Y = observed percentage effect of Product B.

[0196] The expected effect of a given combination of three active ingredients is calculated as follows:

[0197] E=(X+Y+Z)–(XY+YZ+XZ / 100)+(XYZ / 10000)

[0198] in,

[0199] E = the expected percentage effect of mixing three products X, Y and Z at a specified dosage,

[0200] X = observed percentage effect of product A,

[0201] Y = observed percentage effect of product B,

[0202] Z = observed percentage effect of Product C.

[0203] The synergy factor (SF) was calculated by the Abbott formula (Eq. (2)) (Abbott, 1925).

[0204] SF = observed effect / expected effect

[0205] Among them, SF>1 indicates a synergistic reaction; SF<1 indicates an antagonistic reaction; SF=1 indicates an additive reaction.

[0206] When the observed combination yield effect percentage (E) is greater than the expected percentage, it can be inferred that the combination has a synergistic effect. When the observed combination yield effect percentage is equal to the expected percentage, it can be inferred that only an additive effect is present, and when the observed combination yield effect percentage is less than the expected percentage, it can be inferred that the combination has an antagonistic effect.

[0207] Field trial 1: To investigate the effects of triflupromide, tebuconazole and tricyclazole on Helminthosporium oryzae in rice crops.

[0208] The field trial was designed to investigate the efficacy of triflupromide, tebuconazole and tricyclazole against brown leaf spot disease (Helminthosporium oryzae) in rice crops. The combination of triflupromide, tebuconazole and tricyclazole was used to control brown leaf spot disease (Helminthosporium oryzae) in rice crops. The trial was conducted using a randomized block design (RBD) with seventeen treatments including an untreated control group with three replications. The test product samples, triflupromide, tebuconazole and tricyclazole were applied alone or in combination at the prescribed doses through foliar spraying. The rice crop in the trial field was grown in accordance with good agricultural practices.

[0209] Experiment details

[0210] Trial Location Katal, Haryana crop Rice Experimental design RBD Sowing date July 6, 2022 Application type Foliar application Water consumption 500L / hectare Date of first application August 30, 2022 Second application date September 15, 2022 Application time 8:00am to 11:00am Target pathogens Brown spot disease (Helminthosporium oryzae) Plot Area 30 sqm Evaluate Brown spot 15 days after second application Yield Quintal / hectare

[0211] Table 1: Control effect of WG composition consisting of triflupromide, tebuconazole and tricyclazole on Helminthosporium oryzae in rice

[0212]

[0213]

[0214]

[0215] WG: water dispersible granules; *Synergy calculation

[0216] As can be seen from Table 1, compared with the single treatment groups of tebuconazole, tricyclazole, and trifluoropyrimidine and the untreated control group, the application of treatment group 1 (T1) tebuconazole 28.17% w / w + tricyclazole 45% w / w + trifluoropyrimidine 3.78% w / w WG according to the embodiment of the present invention, treatment group 5 (T5) tebuconazole 40% w / w + tricyclazole 30% w / w + trifluoropyrimidine 10% w / w WG according to the embodiment of the present invention, treatment group 9 (T9) tebuconazole 10% w / w + tricyclazole 20% w / w + trifluoropyrimidine 20% w / w WG according to the embodiment of the present invention; treatment group 13 (T13) tebuconazole 5% w / w + tricyclazole 65% w / w + trifluoropyrimidine 1.5% w / w WG according to the embodiment of the present invention is very effective in controlling brown spot disease (Helminthosporium oryzae) of rice crops. It can be seen that treatment groups T1, T5, T9 and T13 showed 95.0%, 93.6%, 94.1% and 94.4% disease reduction, respectively, over the untreated control group, and showed better disease reduction than the individual treatments of tebuconazole, tricyclazole and trifluridine. The surprising synergistic results of treatment groups T1, T5, T9 and T13 are attributed to the composition according to the embodiments of the present invention, wherein all three active ingredients are present in a single composition at specific concentrations. The enhanced efficacy is also attributed to the form of the composition, i.e., the water-dispersible composition shown in this study, which includes microparticles ranging in size from 0.1 microns to 75 microns.

[0217] Furthermore, the compositions according to the examples of the present invention also showed significant increases in yield and other crop characteristics (such as plant height, root length and improved foliage) compared to the yield observed with the application of tebuconazole, trifluridine and tricyclazole alone.

[0218] Field trial data 2: Study on the control effect of triflupromide, tebuconazole and tricyclazole in the formulation of WP, SC and SE on rice sheath blight (Rhizoctonia solani)

[0219] A field trial was conducted to investigate the efficacy of a combination of triflupromide, tebuconazole and tricyclazole formulated as wettable powders, suspension concentrates and emulsions on the control of sheath blight (Rhizoctonia solani) in rice. The trial was conducted using a randomized block design (RBD) with thirteen treatments including an untreated control group, each replicated three times. The test product samples of a specific particle size were compared with the untreated control group. The treatments were applied as foliar sprays 15 days after transplanting the rice in the experimental field. Rice was grown in the experimental field in accordance with good agricultural practices.

[0220]

[0221] Table 2: Effect of synergistic combinations of triflupromide, tebuconazole and tricyclazole formulated as WG, WP, SC and SE on the control of rice sheath blight (Rhizoctonia solani)

[0222]

[0223]

[0224] WP: wettable powder; SC: suspension concentrate; SE: suspoemulsion; *Synergy calculation

[0225] As can be seen from Table 2, compared with the single treatment of tebuconazole, tricyclazole, and trifluoropyrimidine and the untreated control group, the application of tebuconazole 40% w / w + tricyclazole 15% w / w + trifluoropyrimidine 10% w / w SC (65%) according to the embodiment of the present invention in treatment group 1 (T1), tebuconazole 5% w / w + tricyclazole 60% w / w + trifluoropyrimidine 20% w / w WP in treatment group 5 (T5), and tebuconazole 1% w / w + tricyclazole 10% w / w + trifluoropyrimidine 0.1% w / w SE in treatment group 9 (T9) according to the embodiment of the present invention had a good control effect on rice sheath blight (Rhizoctonia solani). It can be seen that treatments T1, T5 and T9 showed 84.4%, 76.9% and 92.7% disease reduction, respectively, compared to the untreated control group, and the disease reduction was better than that of the treatments using tebuconazole, tricyclazole and trifluridine alone. The surprising synergistic results of treatments T1, T5 and T9 are attributed to the composition according to the examples of the present invention, in which all three active ingredients are present in a single composition at specific concentrations. The enhanced efficacy is further attributed to the form of the composition. The enhanced efficacy is further attributed to the form of the composition, i.e., WP, SC, SE shown in this study, which includes microparticles ranging in size from 0.1 microns to 75 microns.

[0226] Furthermore, the compositions exemplified by the present invention also showed significant increases in yield and other crop characteristics such as plant height, root length and foliage improvement compared to the yield observed with the application of tebuconazole, trifluridine and tricyclazole alone.

[0227] Field trial data 3: Study of the effects of a combination of triflupromide, tebuconazole and tricyclazole; a two-way combination of known active ingredients and a single active ingredient on controlling rice blast (Pyricularia orizae)

[0228] A field trial was conducted to compare the effects of a composition comprising triflupromide, tebuconazole and tricyclazole; a two-way combination of known active ingredients and individual active ingredients on the control of rice blast (Pyricularia orizae). The trial was conducted using a randomized block design (RBD) with eight treatments including an untreated control group, each replicated three times. The test product samples having a specific particle size were compared with an untreated control group. The treatments were applied as foliar sprays 15 days after transplanting the rice in the experimental fields. The cultivation of rice in the experimental fields followed good agricultural practices.

[0229]

[0230]

[0231] Table 3: Synergistic effect of compositions comprising triflupromide, tebuconazole and tricyclazole; comparison with known two-way combinations of active ingredients and individual active ingredients for controlling rice blast (Pyricularia orizae) in rice crops

[0232]

[0233]

[0234]

[0235] WG: water dispersible granules; *Synergy calculation

[0236] As can be seen from Table 3, treatment group T1, which applied a combination of tebuconazole, tricyclazole and triflupyrimidine prepared according to the examples of the present invention, was very effective in controlling rice blast (Pyricularia orizae) in rice crops, and cucumber yield was increased compared to the two-way combination treatment groups (T2, T3 and T4) and the individual treatment groups of the active ingredients (T5, T6 and T7). The surprising synergistic results of treatment group T1 are attributed to the combination of tebuconazole, tricyclazole and triflupyrimidine according to the embodiments of the present invention, wherein all three active ingredients are present in a single composition at specific concentrations. The enhanced efficacy is also attributed to the form of the composition shown in this study as a water-dispersible granule, which includes microparticles ranging in size from 0.1 microns to 75 microns.

[0237] Furthermore, the compositions exemplified in the present invention also showed significant improvement in yield and other crop characteristics (such as plant height, root length and leaf improvement) compared to the known two-way combination and individual application of tebuconazole, trifluridine and tricyclazole.

[0238] Field trial data 4: The control effect of a combination of triflupromide, tebuconazole and tricyclazole having a specific particle size on brown planthopper (Nilaparvata lugens) in rice was studied.

[0239] A field trial was conducted to investigate the efficacy of a combination of triflupromide, tebuconazole and tricyclazole with a specific particle size on the control of brown planthopper (Nilaparvata lugens) in rice. The trial was conducted using a randomized block design (RBD) with seven treatments including an untreated control group, each replicated three times. The test product samples with a specific particle size were compared with the untreated control group. The treatments were applied as foliar sprays 15 days after transplanting the rice in the experimental field. The cultivation of rice in the experimental field followed good agricultural practices.

[0240] Trial Location Rajahmundry, Andhra Pradesh crop Rice Experimental design RBD Sowing date July 6, 2022 Application type Foliar application Water consumption 500L / hectare Date of first application September 20, 2022 Second application date October 5, 2022 Application time 8:00am to 11:00am Target pathogens Brown Planthopper (Nilaparvata lugens) Plot Area 30 sqm Evaluate Brown planthopper (BPH) counts - 15 days after second application Yield Quintal / hectare

[0241] Table 4: Control effect of compositions comprising triflupromide, tebuconazole and tricyclazole of specific particle sizes on brown planthopper (BPH) (Nilaparvata lugens) in rice

[0242]

[0243]

[0244]

[0245] WG: Water dispersible granules

[0246] As can be seen from Table 4, treatment group 1 (T1) with a particle size distribution range of 0.1 to 75 μm showed higher yield and better disease reduction effect in rice crops compared with treatment group 2 (T2) with a particle size range of 75 to 100 μm, treatment group 3 (T3) with a particle size range of 100 to 150 μm and the untreated control group.

[0247] In addition, when treatment group 1 with a particle size of 0.1 to 75 microns, treatment group 2 with a particle size of 75 to 100 microns, and treatment group 3 with a particle size of 100 to 150 microns were applied to rice crops at a dosage of 666.5 g / hectare, the yield increased by about 56.4%, 50.9%, and 49.7%, respectively, compared with the control group.

[0248] Therefore, surprisingly, even among WDG formulations, superior efficacy was observed for WDG formulations having a specific particle size distribution from 0.1 to 75 microns compared to WDG formulations having different particle sizes in different ranges.

Claims

1. A synergistic pesticide combination comprising: 0.1% w / w to 20% w / w of trifluoropyrimidine in the total composition; 1% w / w to 50% w / w of tebuconazole in the total composition; and 10% w / w to 70% w / w of tricyclazole in the total composition.

2. A pesticide composition comprising: 0.1% w / w to 20% w / w of trifluoropyrimidine in the total composition; 1% w / w to 50% w / w of tebuconazole in the total composition; and 10% w / w to 70% w / w of tricyclazole in the total composition; and at least one agrochemically acceptable excipient; wherein the particle size of the composition is in the range of 0.1 micron to 75 microns.

3. The pesticide composition according to claim 2, wherein The composition is in the form of a solid or liquid or a gel.

4. The pesticide composition according to claim 3, wherein The solid composition is in the form of granules, including spheronized granules, extruded granules, water-disintegrating granules, wettable powders, water-dispersible granules, dustable powders (DP), powders for dry seed treatment (DS), water-disintegrating tablets or water-dispersible powders for slurry seed treatment (WS).

5. The pesticide composition according to claim 3, wherein The liquid pesticide composition is a liquid suspension or suspension concentrate (SC); suspoemulsion (SE), oil dispersion (OD), flowable concentrate (FC) or suspension concentrate (FS) for seed treatment, ultra low volume (ULV).

6. The pesticide composition according to claim 4, wherein The water dispersible granules have a size range of 0.025 mm to 3 mm.

7. The pesticide composition according to claim 4, wherein The size of the granules ranges from 0.025 mm to 6 mm.

8. The pesticide composition according to claim 2, wherein The composition further comprises at least one active ingredient selected from the group consisting of pesticide active substances, fertilizers, macronutrients, micronutrients, biostimulants, organic acids, plant growth regulators, algae, and mixtures thereof.

9. The pesticide composition according to claim 2, wherein The agrochemically acceptable excipient is selected from at least one of the following: surfactants, adhesives or binders, wetting agents, emulsifiers, fillers or carriers or diluents, coating agents, buffers or pH adjusters or neutralizers, defoamers or defoamers, penetrants, UV protectants, UV absorbers, UV scatterers, stabilizers, pigments, colorants, structurants, chelating agents or complexing agents or multivalent sequestrants, thickeners, suspending agents or suspension aids or anti-caking agents or anti-settling agents, viscosity regulators or rheology regulators, tackifiers, humectants, spreading agents, adhesives, antifreeze agents or freezing point depressants, solvents, preservatives or bactericides or antifungal agents or biocides or antimicrobial agents or antioxidants, polymers, monomers, cross-linking agents, permeability enhancers, protective colloids and mixtures thereof.

10. The pesticide composition according to claim 5, wherein The viscosity of the liquid composition is 10 cps to 3000 cps.

11. The pesticide composition according to claim 5, wherein The pourability of the liquid composition is less than 5% residue.

12. The pesticide composition according to claim 4, wherein The composition has a dispersibility of at least 30%.

13. The pesticide composition according to claim 4, wherein The composition has a suspensibility of at least 30%.

14. A method for preparing a pesticide composition in the form of water-dispersible granules according to claim 4, comprising: a) grinding a mixture of trifluridine, tebuconazole and tricyclazole together with at least one agrochemical excipient in water to obtain a slurry or wet mixture, wherein the size of the microparticles ranges from 0.1 to 75 microns; and b) drying the wet mixture, sieving the dried mixture to remove undersized and oversized granules to obtain water dispersible granules; The granules of the composition are composed of granules with a size range of 0.025 mm to 3 mm.

15. The method for preparing the pesticide composition in granule form according to claim 4, comprising: a. grinding and mixing trifluridine, tebuconazole and tricyclazole with at least one agrochemical excipient in water to obtain a slurry or wet mixture, wherein the size of the microparticles ranges from 0.1 to 75 microns; b. drying the wet mixture to obtain a dry mixture; wherein the granules of the composition comprise granules having a size range of 0.025 mm to 3 mm, and c. adding water to the dry mixture and mixing to obtain a mass or paste, extruding through an extruder to obtain extruded granules having a size range of 0.025 mm to 6 mm; or The wet mixture or the dry mixture obtained in step (b) is agglomerated in an agglomerator to obtain a spheronized granule composition having a size ranging from 0.025 mm to 6 mm.

16. A method for preparing a wettable powder or a pesticide composition in the form of a wettable powder for seed coat according to claim 4, comprising: a) mixing triflupromide, tebuconazole and tricyclazole with at least one agrochemical excipient; b) grinding the mixture obtained in step a) to obtain a wettable powder; Wherein, the size of the particles ranges from 0.1 to 75 microns.

17. A method for preparing a pesticide composition in the form of a liquid suspension according to claim 5, wherein the method comprises: a) homogenizing a mixture of triflupromide, tebuconazole and tricyclazole with at least one agrochemical excipient to obtain a suspension; and b) wet milling the resulting suspension to provide a composition having a particle size ranging from 0.1 microns to 75 microns.

18. A method for preparing a pesticide composition in the form of a suspension according to claim 5, wherein the method comprises: a. homogenizing a mixture of trifluoropyrimidine and tricyclazole with at least one agrochemical excipient to obtain a suspension; and wet-milling the resulting suspension to provide a suspension concentrate of trifluoropyrimidine and tricyclazole having a particle size range of 0.1 to 75 microns; b. dissolving tebuconazole in oil or solvent and at least one agrochemically acceptable excipient to obtain an emulsion concentrate of tebuconazole; c. mixing the suspension concentrate of step a) and the emulsion concentrate of step b) with an agrochemical excipient to obtain a suspension composition having a particle size ranging from 0.1 to 75 microns.

19. A method for controlling fungal diseases, protecting crops or improving plant health and yield, comprising treating at least one of plants, crops, plant propagation materials, sites, parts thereof or seeds, seedlings and soil with the pesticide composition of claim 2.

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