A microbubble generator

Abstract

The invention relates to a microbubble generator, a syringe, an injection needle, a microbubble generating component and an auxiliary device for foaming experiment operation. The front part of the syringe is sealed and connected with the proximal end of the mounting shell, and the output end of the syringe is connected with the fluid inlet of the microbubble generating component. By setting a fixing frame and a power device, the situation that the operator pushes a contrast agent at a slow speed or the number of pushes is different can be greatly reduced, and a more effective detection effect can be achieved. At the same time, through a unique microbubble mixer, the operator is not required to rely on a manual oscillation method for detection. Moreover, by setting the microbubble generating component in the microbubble generator, the mixing amount of gas in a unit liquid can be increased, so that the mixed gas volume is smaller and the amount is larger. In combination with the surfactant dissolved in the liquid, a large number of mixed microbubbles are made more stable, so that the contrast agent can be used to achieve an ideal diagnostic effect.

Description

Technical Field

[0001] The invention belongs to the technical field of medical devices, and in particular relates to a microbubble generator. Background Art

[0002] Patent foramen ovale occupies a very important position in the screening of stroke causes. According to research, the incidence rate of patent foramen ovale is about 25%, which is an important factor leading to stroke in young and middle-aged people and a serious threat to human life safety. At the same time, according to the requirements of the National Health Commission, stroke centers established in various large and small hospitals must carry out foaming test projects before they can pass the stroke center acceptance. Therefore, foaming test examinations have been widely carried out in clinical work.

[0003] The foaming test is characterized by low trauma, high patient cooperation, long manual operation time and high frequency. It is the only high-accuracy test item for screening patent foramen ovale. The most critical step in the foaming test is to artificially create microemboli (1ml of the patient's own blood + 8ml of saline + 1ml of air, fully mixed) and then inject them into the peripheral veins of the human body. With the beating of the heart, the signal detection is carried out at the right time to achieve the purpose of diagnosing the disease.

[0004] The microemboli injected into the blood vessels, i.e. the mixture containing the patient's blood, saline and air, are required to be small, dense and injected quickly. The whole process takes a long time for manual operation and the connection time is tight, which can easily cause body fluid splashing, resulting in occupational exposure of medical staff and medical safety risks. At the same time, inexperienced operators inject contrast agents slowly or at different times, resulting in poor contrast agent mixing effect, which leads to the contrast effect of foaming not meeting expectations and affecting diagnosis. Therefore, an auxiliary device for foaming operation is urgently needed. Summary of the invention

[0005] In view of this, the present invention provides a microbubble generator, which can achieve stable control of the syringe during the foaming experiment operation by setting a fixing frame and a power device, so that the pushing speed is controllable, and by setting a microbubble generating component in the microbubble generator, the mixing amount of gas in the unit liquid can be increased, so that the volume of the mixed gas is smaller and the amount is larger, and a surfactant is dissolved in the liquid to make the mixed large number of microbubbles more stable, so that the contrast agent can achieve an ideal diagnostic effect.

[0006] The technical solution adopted by the present invention is:

[0007] A microbubble generator comprises: a syringe, an injection needle, a microbubble generating assembly and a booster device, wherein the syringe is connected to the injection needle via the microbubble generating assembly, and the booster device is connected to the syringe to control the operation of the syringe, and a surfactant coating is arranged in the syringe or / and the microbubble generator.

[0008] Further optimization of the technical solution of the present invention includes a fixed frame and a power device; the fixed frame includes: a support beam, a mounting beam and a mounting shell, the number of the support beams is two and they are symmetrically arranged, the two ends of the mounting beam are respectively connected to the proximal ends of the two support beams, a syringe fixing beam is arranged in the middle of the support beam, and a limiting groove is arranged at the free end of the syringe fixing beam; the mounting shell is fixed to the distal end of the support beam through a connecting beam to fix the output end of the syringe and install the foaming component, and a Luer joint is arranged at the distal end of the mounting shell; the power device includes a driving component and a moving slider, the driving component is fixed on the mounting beam, the moving slider is provided with a connection to the power output end of the driving component, and the moving slider moves up and down under the action of the driving component.

[0009] Further optimization of the technical solution of the present invention is that the driving assembly includes a micro motor and a transmission screw, the proximal end of the transmission screw is connected to the output shaft of the micro motor, and the distal end is installed on the syringe fixed beam through a bearing, and the movable slider is provided with a driven nut that cooperates with the transmission screw.

[0010] In a further optimization of the technical solution of the present invention, arc-shaped chamfers are provided between the front and rear side surfaces of the syringe fixing beam and the limiting groove.

[0011] According to a further optimization of the technical solution of the present invention, the mounting shell is in the shape of a cylinder with an opening at the proximal end, and a sealing groove for mounting a sealing ring is provided on the inner side of the upper portion of the mounting shell.

[0012] According to a further optimization of the technical solution of the present invention, a fixed groove is provided on the side of the movable slider in contact with the syringe, and the fixed groove is used to limit the piston handle of the syringe.

[0013] Further optimization of the technical solution of the present invention is that the front part of the syringe is sealed and connected to the proximal end of the mounting shell, and the output end of the syringe is connected to the fluid inlet of the microbubble generating assembly; the microbubble generating assembly is arranged in a sealed cavity formed between the syringe and the mounting shell; and the output end of the microbubble generating assembly is connected to the distal end of the mounting shell; the injection needle is installed on the mounting shell through the Luer connector; an air chamber is arranged between the microbubble generating assembly and the inner wall of the mounting shell, and the air chamber is used to provide gas to the microbubble generating assembly.

[0014] Further optimization of the technical solution of the present invention, the microbubble generating component includes a main body and a fixed wing, the fixed wing is arranged on the main body, and the inner wall of the mounting shell is provided with a fixing groove matching the fixed wing; a connecting head is provided at the far end of the main body, and a mounting groove sealingly connected to the connecting head is provided at the lower part of the mounting shell.

[0015] Further optimization of the technical solution of the present invention, the main body includes an integrally arranged syringe connector, an inflow channel, a gas-liquid mixing channel and an outflow channel, the syringe connector is arranged at the end of the outflow channel, the gas-liquid mixing channel is provided with a first through hole connected to the air chamber, the inflow channel and / or the outflow channel is provided with a second through hole connected to the air chamber.

[0016] According to a further optimization of the technical solution of the present invention, the gas-liquid mixing channel comprises a contraction section, a straight section and a diffusion section, the first through hole is provided on the body corresponding to the straight section, and the surfactant coating is provided on the straight section.

[0017] Beneficial effects of the present invention:

[0018] By designing the fixing frame, the effect of stably fixing the syringe can be achieved, especially the syringe fixing beam and the mounting shell structure. The syringe can be conveniently and quickly installed on the fixing frame through the syringe fixing beam, and the syringe and the fixing frame can be tightly combined through the structural design of the mounting shell, providing a second support point for the syringe, thereby improving the stability of the syringe during operation; by setting up a power device, human intervention can be omitted, thereby reducing operational errors and medical risks caused by human factors during operation.

[0019] A microbubble generator is made based on the auxiliary device and combined with a microbubble generating component. It can quickly produce a contrast agent with a small gas volume and high density under the action of the microbubble generating component. By providing a surfactant coating on the inner surface of the syringe, it can be dissolved in the liquid during the injection process, thereby improving the stability of the gas in the liquid and allowing small, high-density bubbles to enter the detection position for assisted diagnosis through contrast imaging. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] The above and other objects, features and advantages of the present invention will become more apparent through the following description of the embodiments of the present invention with reference to the accompanying drawings, in which:

[0021] Figure 1 It is a structural schematic diagram of the fixing frame of the present invention;

[0022] Figure 2 It is a schematic diagram of the structure of the power device of the present invention;

[0023] Figure 3 It is a schematic diagram of the overall structure of the installation shell of the present invention;

[0024] Figure 4 yes Figure 3 A cross-sectional view along BB after the middle installation shell and the microbubble generating assembly are assembled;

[0025] Figure 5 yes Figure 3 A cross-sectional view of the middle installation shell along BB;

[0026] Figure 6 is a top view of the main body in the microbubble generating assembly of the present invention;

[0027] Figure 7 It is a schematic diagram of the cross-sectional structure of the main body;

[0028] Figure 8 It is a schematic diagram of the overall component structure of the microbubble generator of the present invention;

[0029] Fig. 9 It is a partial structural schematic diagram of the microbubble generator of the present invention;

[0030] Fig.10 This is a schematic diagram of the application of the Fa Ming microbubble generator.

[0031] In the figure: 1. fixing frame; 2. power device; 3. syringe; 4. injection needle; 5. microbubble generating assembly;

[0032] 11. Support beam; 111. Syringe fixing beam; 112. Limiting groove; 12. Mounting beam; 13. Mounting shell; 131. Luer connector; 132. Mounting groove; 133. Air chamber; 134. Fixing groove; 14. Connecting beam; 15. Power supply box;

[0033] 21. Micro motor; 22. Moving slider; 23. Transmission screw; 24. Bearing;

[0034] 31. Syringe barrel; 32. Piston handle;

[0035] 51. Inflow channel; 52. Gas-liquid mixing channel; 521. Contraction section; 522. Straight section; 523. Diffusion section; 53. Outflow channel; 54. First through hole; 55. Syringe connector; 56. Connector; 57. Second through hole; 58. Fixed wing. DETAILED DESCRIPTION

[0036] The present invention is described below based on embodiments, but the present invention is not limited to these embodiments. In the following detailed description of the present invention, some specific details are described in detail. In order to avoid confusing the essence of the present invention, known methods, processes, procedures, and components are not described in detail.

[0037] In addition, persons of ordinary skill in the art will appreciate that the drawings provided herein are for illustration purposes and are not necessarily drawn to scale.

[0038] Unless the context clearly requires otherwise, throughout the specification and claims, the words "include", "comprising" and similar words should be interpreted in an inclusive sense rather than an exclusive or exhaustive sense; that is, in the sense of "including but not limited to".

[0039] In the description of the present invention, it should be understood that the terms "first", "second", etc. are only used for descriptive purposes and cannot be understood as indicating or implying relative importance. In addition, in the description of the present invention, unless otherwise specified, "plurality" means two or more.

[0040] Combined with the following Figure 1-Figure 10 The technical solution of this application is described in detail.

[0041] The present invention provides an auxiliary device for foaming experiment operation. Through the design of mechanical structure, in the contrast detection of patent foramen ovale, the detection error caused by human participation can be reduced, and the detection structure can be stabilized. Compared with the method of artificially making bubbles and pushing the syringe 3 in the prior art, generally 2-3 times of detection are required to obtain an accurate judgment. After reducing the human error, basically one contrast examination can be conducted to obtain an accurate diagnosis effect, which improves the detection efficiency and reduces the pain of patients. Specifically, the auxiliary device of the technical solution includes a fixing frame 1 and a power device 2; Figure 1As shown, the fixing frame 1 includes: a support beam 11, a mounting beam 12 and a mounting shell 13. The number of the support beams 11 is two and they are symmetrically arranged. The two ends of the mounting beam 12 are respectively connected to the proximal ends of the two support beams 11, and the connection method can be screw fixing connection, mortise and tenon structure connection, etc.; a syringe fixing beam 111 is arranged in the middle of the support beam 11, and a limiting groove 112 is arranged at the free end of the syringe fixing beam 111. In conjunction with the two symmetrically arranged support beams 11 structure, a syringe 3 clamping space is formed between the two syringe fixing beams 111, and through the limiting groove 112 can stably clamp the syringe 3, improving the stability during operation; the mounting shell 13 is fixed to the distal end of the support beam 11 through the connecting beam 14. By setting the mounting shell 13, a second supporting point can be provided for the syringe 3, so that the syringe 3 and the fixing frame 1 are closely matched, enhancing the stability and safety during operation. In a preferred embodiment, in order to improve the stability of the mounting shell 13, the connecting beam 14 can be set to an inclined structure with a certain angle with the support beam 11, or the connecting beam 14 can be set to a right-angled triangle structure, one of the right-angled sides is connected to the outer wall of the mounting shell 13. Because there is a mounting space reserved in the mounting shell 13, a Luer connector 131 is provided at the distal end of the mounting shell 13 to facilitate the output end of the syringe 3 to be directly or indirectly connected to the injection needle 4. In order to facilitate the control of the syringe 3, the power device 2 includes a driving assembly and a moving slider 22. The driving assembly is fixed on the mounting beam 12, and the moving slider 22 is provided with a connection to the power output end of the driving assembly, and the moving slider 22 moves up and down under the action of the driving assembly. The driving component in this technical solution can use a plug-in power connection structure, or a power supply can be set on the support beam 11 and fixed with a power box 15.

[0042] The driving assembly can be a cylinder driving structure or a screw nut driving structure. When it is a cylinder driving structure, the telescopic rod of the cylinder controls the moving slider 22 to drive the syringe 3 to work. Figure 2 As shown, the driving assembly includes a micro motor 21 and a transmission screw 23. The proximal end of the transmission screw 23 is connected to the output shaft of the micro motor 21, and the distal end is mounted on the syringe fixed beam 111 through a bearing 24. The moving slider 22 is provided with a driven nut that matches the transmission screw 23. By providing the micro motor 21, the speed of the micro motor 21 can be intelligently controlled in conjunction with the PLC controller, so that the driving speed of the moving slider 22 can be controlled by the transmission screw 23, and the operation of the syringe 3 can be controlled stably and controllably.

[0043] In order to facilitate the installation of the syringe 3, arc-shaped chamfers are arranged between the front and rear sides of the syringe fixing beam 111 and the limiting groove 112. By utilizing the deformation property of the syringe 3 itself, the distance between the centers of the two limiting grooves 112 is equal to the diameter of the syringe 3. In this way, when installing, the syringe 3 can be pressed slightly to insert the syringe 3 into the limiting groove 112, and the limiting groove 112 can tightly fix the syringe 3.

[0044] According to the preferred technical solution of the present application, the mounting shell 13 is in the shape of a cylinder with an opening at the proximal end, and a sealing groove for mounting a sealing ring is provided on the inner side of the upper portion of the mounting shell 13, so as to prevent the injection liquid of the syringe 3 from splashing during the installation process, and at the same time, the restraining effect of the sealing ring is utilized to increase the stability of the syringe 3 during operation.

[0045] In addition, in order to realize the control of the push or pull of the syringe 3 by the driving component, a fixed card slot is provided on the side where the movable slider 22 contacts the syringe 3, and the fixed card slot is used to limit the piston handle 32 of the syringe 3. Specifically, the fixed card slot is a T-shaped slot or the movable slider 22 is provided as two parts separated into upper and lower parts. The auxiliary device for the foaming experiment operation of the present technical solution can be used in combination with the foaming component, or two devices can cooperate with each other, one for placing the syringe 3 with gas drawn, and the other for placing the syringe 3 with liquid drawn. The two devices cooperate with each other to pull and pull to achieve the effect of gas-liquid mixing, replacing manual operation. When used in combination with the foaming component, the movable slider 22 mainly has the function of pushing, and the structure of the fixed card slot can be omitted.

[0046] The method of using the auxiliary device for foaming experiment operation in the technical solution is as follows: first insert the distal end of the syringe 3 into the mounting shell 13, then move the syringe 3 in the direction of overlapping the fixed frame 1, and when the syringe 3 contacts the arc-shaped chamfer of the limiting groove 112, press the syringe barrel 31 of the syringe 3 hard to make it snap into the limiting groove 112, and then adjust the moving slider 22 so that the lower surface of the moving slider 22 contacts the upper surface of the piston handle 32 to achieve the function of pushing the injection. When the auxiliary device is used for gas-liquid mixing, the two syringes 3 cooperate with each other. During installation, when the syringe barrel 31 contacts the arc-shaped chamfer of the limiting groove 112, adjust the position of the moving slider 22 so that the fixed card groove corresponds to the piston handle 32.

[0047] The technical solution of the present invention also provides a microbubble generator, including a syringe 3, an injection needle 4, a microbubble generating assembly 5 and an auxiliary device for the foaming experiment operation described above, the front part of the syringe 3 is sealed and connected to the proximal end of the mounting shell 13, and the output end of the syringe 3 is connected to the fluid inlet of the microbubble generating assembly 5; the microbubble generating assembly 5 is arranged in a sealed cavity formed between the syringe 3 and the mounting shell 13; and the output end of the microbubble generating assembly 5 is connected to the distal end of the mounting shell 13; the injection needle 4 is installed on the mounting shell 13 through the Luer connector 131; an air chamber 133 is arranged between the microbubble generating assembly 5 and the inner wall of the mounting shell 13, and the air chamber 133 is used to provide gas to the microbubble generating assembly 5. This technical solution can be directly used to make contrast agents, and the liquid in the syringe 3 and the gas in the air chamber 133 can be mixed through the microbubble generating assembly 5. Moreover, the auxiliary device used for the foaming experiment operation can achieve uniform quick freezing advancement, so that the foaming rate and injection rate are both kept stable, reducing the imaging examination error caused by human factors. The syringe 3 is preferably 5ml or 10ml, and the injection needle 4 is selected from 18G-22G.

[0048] In this embodiment, the microbubble generating component 5 includes a main body and a fixed wing 58, wherein the fixed wing 58 is arranged on the main body, and the inner wall of the mounting shell 13 is provided with a fixed groove 134 matching with the fixed wing 58. When the main body is inserted from the upper part of the mounting shell 13, the fixed wing 58 can be placed corresponding to the fixed groove 134, so that the main body is stably fixed in the mounting shell 13, and through the fixed wings 58 (at least two) symmetrically arranged on the periphery of the main body, the fluid channel of the main body can be positioned at the center of the mounting shell 13, which is convenient for connecting the output port of the syringe 3 with the main body; further, in order to fix the main body and ensure the sealing box of the fluid channel, a connector 56 is provided at the distal end of the main body, and a mounting groove 132 sealingly connected to the connector 56 is provided at the lower part of the mounting shell 13, and a sealing groove for placing a sealing ring is provided on the periphery of the connector 56.

[0049] In order to achieve efficient gas-liquid mixing, the main body includes an integrally arranged syringe connector 55, an inflow channel 51, a gas-liquid mixing channel 52 and an outflow channel 53, the syringe connector 55 is arranged at the end of the outflow channel 53, the gas-liquid mixing channel 52 is provided with a first through hole 54 connected to the air chamber 133, the diameter of the first through hole 54 is 0.1mm-0.2mm, and the inflow channel 51 and / or the outflow channel 53 are provided with a second through hole 57 connected to the air chamber 133. The gas-liquid mixing channel 52 includes a contraction section 521, a straight section 522 and a diffusion section 523. The first through hole 54 is opened on the main body corresponding to the straight section 522. When working, liquid is pressed into the body through the syringe 3. When the liquid flows through the inflow channel 51, it will flow into the air chamber 133 through the second through hole 57 under the action of the static pressure of the liquid. Similarly, when flowing through the outflow channel 53, the liquid will also enter the air chamber 133 through the second through hole 57. However, when flowing into the gas-liquid mixing channel 52, due to the action of the contraction section 521, the flow rate of the fluid will be accelerated. The flow rate is the fastest in the straight section 522, and the static pressure of the fluid is the smallest. At this time, the gas in the air chamber 133 will enter the liquid through the first through hole 54 to achieve mixing of the gas phase and the liquid phase. By setting the second through hole 57, when liquid flows into the air chamber 133, the gas-liquid in the air chamber 133 can be increased, so that the pressure difference between the inside and outside of the first through hole 54 is increased, which is more conducive to the mixing of gas into the liquid. By controlling the size and number of the first through holes 54, the density and size of the mixed gas in the liquid can be adjusted, and when the fluid passes through the diffusion section 523, turbulence will be formed, which can further shear the bubbles mixed in the straight section 522 into smaller bubbles, thereby achieving the effect of bubble creation in the liquid.

[0050] In order to improve the stability of bubbles in the liquid and the convenience of experimental operation, the inner surface of the syringe 3 used in the present scheme is provided with a surfactant coating. When the syringe 3 draws liquid during use, the surfactant can dissolve into the liquid to maintain the stability of the liquid phase. When a large number of bubbles are mixed in, the merging of the bubbles can be reduced. Similarly, the surfactant can also be coated on the straight section 522 of the gas mixing channel, so that the surfactant and the liquid can be mixed when physiological saline is extracted.

[0051] The working process of the microbubble generator of this technical solution is as follows:

[0052] After the syringe 3 extracts an appropriate amount of liquid, it is loaded into the fixing frame 1, so that the syringe 3 is connected to the body of the microbubble generating component 5, and the micromotor 21 is started to drive the transmission screw 23 to rotate. The rotation of the transmission screw 23 causes the moving slider 22 to move downward, thereby generating downward pressure on the piston handle 32 of the syringe 3, so that the liquid inside the syringe 3 moves toward the body of the microbubble generating component 5, generating a certain flow rate. When the liquid enters the contraction channel at a certain speed from the inflow channel 51, the gas in the air chamber 133 will enter the liquid from the first through hole 54, thereby mixing with the liquid in the outflow channel 53, forming microbubbles and injecting them into the veins. The mixed microbubbles enter the right atrium of the heart through the veins; if there is a patent foramen ovale, the generated microbubbles will enter the left atrium through the patent foramen ovale, thereby completing the detection of the symptoms of the patent foramen ovale. In this process, the pressure is controlled by the driving component, which greatly reduces the situation where the operator injects the contrast agent at a slow speed or at different times, thus achieving a more effective detection effect. At the same time, the unique microbubble mixer eliminates the need for the operator to rely on manual oscillation for detection.

[0053] It should be understood that the above-mentioned embodiments are merely illustrative and not restrictive. Without departing from the basic principles of the present invention, various obvious or equivalent modifications or substitutions that can be made by those skilled in the art to the above-mentioned details will be included in the scope of the claims of the present invention.

Claims

1. A microbubble generator, characterized in that: include: A syringe, an injection needle, a microbubble generating assembly and a booster device, wherein the syringe is connected to the injection needle through the microbubble generating assembly, and the booster device is connected to the syringe to control the operation of the syringe, and a surfactant coating is provided in the syringe or / and the microbubble generator; The booster device comprises a fixing frame and a power device; The fixing frame comprises: a support beam, a mounting beam and a mounting shell. The number of the support beams is two and they are symmetrically arranged. The two ends of the mounting beam are respectively connected to the proximal ends of the two support beams. A syringe fixing beam is arranged in the middle of the support beam, and a limiting groove is arranged at the free end of the syringe fixing beam. The mounting shell is fixed to the distal end of the support beam through a connecting beam to fix the output end of the syringe and install the foaming component, and a Luer connector is arranged at the distal end of the mounting shell. The power device comprises a driving assembly and a moving slider, wherein the driving assembly is fixed on the mounting beam, the moving slider is provided with a power output end connected to the driving assembly, and the moving slider moves up and down under the action of the driving assembly; The front part of the syringe is sealed and connected to the proximal end of the mounting shell, and the output end of the syringe is connected to the fluid inlet of the microbubble generating assembly; the microbubble generating assembly is arranged in a sealed cavity formed between the syringe and the mounting shell; and the output end of the microbubble generating assembly is connected to the distal end of the mounting shell; the injection needle is installed on the mounting shell through the Luer connector; an air chamber is arranged between the microbubble generating assembly and the inner wall of the mounting shell, and the air chamber is used to provide gas to the microbubble generating assembly.

2. The microbubble generator according to claim 1, characterized in that The driving assembly includes a micro motor and a transmission screw, wherein the proximal end of the transmission screw is connected to the output shaft of the micro motor, and the distal end is mounted on the syringe fixed beam through a bearing, and a driven nut matching the transmission screw is arranged on the movable slider.

3. The microbubble generator according to claim 1, characterized in that Arc-shaped chamfers are arranged between the front and rear side surfaces of the syringe fixing beam and the limiting groove.

4. The microbubble generator according to claim 1, characterized in that: The mounting shell is in the shape of a cylinder with an opening at the proximal end, and a sealing groove for mounting a sealing ring is arranged on the inner side of the upper portion of the mounting shell.

5. The microbubble generator according to claim 1, characterized in that: A fixed groove is arranged on the side of the movable sliding block in contact with the syringe, and the fixed groove is used to limit the piston handle of the syringe.

6. The microbubble generator according to claim 1, characterized in that: The microbubble generating assembly includes a body and a fixed wing, wherein the fixed wing is arranged on the body, and the inner wall of the mounting shell is provided with a fixing groove matching with the fixed wing; a connecting head is provided at the far end of the body, and a mounting groove sealingly connected with the connecting head is provided at the lower part of the mounting shell.

7. The microbubble generator according to claim 6, characterized in that: The main body includes an integrally arranged syringe connector, an inflow channel, a gas-liquid mixing channel and an outflow channel, the syringe connector is arranged at the end of the outflow channel, the gas-liquid mixing channel is provided with a first through hole connected to the air chamber, and the inflow channel or / and the outflow channel is provided with a second through hole connected to the air chamber.

8. The microbubble generator according to claim 7, characterized in that: The gas-liquid mixing channel comprises a contraction section, a straight section and a diffusion section, the first through hole is provided on the body corresponding to the straight section, and the surfactant coating is arranged on the straight section.

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