Flexible Microelectrode Implantation Device, Implantation Equipment and Implantation System

Abstract

The present application relates to a flexible microelectrode implantation device, an implantation device, and an implantation system. The implantation device includes a base, a plurality of implantation needle assemblies, a plurality of flexible microelectrodes, and an implantation control member; each implantation needle assembly includes a fixed seat and an auxiliary implantation needle that are connected to each other. The plurality of fixed seats are detachably connected to the base, and each auxiliary implantation needle is respectively connected to one of the flexible microelectrodes; the implantation control member includes a first magnetic member, and each fixed seat includes a second magnetic member. The implantation control member is magnetically attracted to the second magnetic member on each fixed seat through the first magnetic member, thereby driving each fixed seat and the corresponding auxiliary implantation needle away from the base, and realizing the implantation of the corresponding flexible microelectrode into a preset position in the brain region. Through this kind of setting, it is possible to dynamically select the implantation area and implantation depth of each auxiliary implantation needle, and the magnetic attraction control method can achieve single-needle rapid implantation without reducing the implantation efficiency.

Description

Technical Field

[0001] This application relates to the technical field of electrode implantation, and particularly to a flexible microelectrode implantation device, an implantation device, and an implantation system. Background Art

[0002] As an interdisciplinary technology, the brain-computer interface has received extensive attention from the scientific research community and the industrial community worldwide. As the preferred choice for the brain-computer interface, the biggest advantage of flexible microelectrodes is that they are not likely to form scars in brain tissue. However, due to the low mechanical strength and easy deformation of flexible microelectrodes themselves, it is not easy to penetrate the meninges and enter the tissue. Therefore, an auxiliary implantation needle is usually used to assist the implantation of flexible microelectrodes.

[0003] Chinese Patent Application CN115736935A involves a brain electrode implantation device and a brain electrode implantation system. It connects a control circuit board with multiple flexible microelectrodes, fixes multiple auxiliary implantation needles with a base, and realizes the auxiliary implantation of flexible microelectrodes into the brain area of the implantee through the corresponding connection between the flexible microelectrodes and the auxiliary implantation needles. Combining its specification, it can be known that the problems that are more likely to occur in actual operation are that when there are multiple auxiliary implantation needles, the implantation area and implantation depth of each auxiliary implantation needle cannot be dynamically selected, and all auxiliary implantation needles can only be inserted into the brain area within a preset range. As a result, some flexible microelectrodes may be implanted outside the measured brain area, the implantation depth of each flexible microelectrode cannot be adjusted as needed, and the implanted position may interfere with blood vessels, thus piercing the blood vessels and causing bleeding. Summary of the Invention

[0004] In view of this, this application provides a flexible microelectrode implantation device, an implantation device, and an implantation system. It can at least solve the technical problem that when multiple auxiliary implantation needles are fixed with a base, the implantation area and implantation depth of each auxiliary implantation needle can be dynamically selected, and the implantation efficiency will not be reduced.

[0005] According to one aspect of this application, a flexible microelectrode implantation device is provided. The flexible microelectrode implantation device includes a base, multiple implantation needle assemblies, multiple flexible microelectrodes, and an implantation control member;

[0006] Each of the implantation needle assemblies includes a fixed seat and an auxiliary implantation needle that are connected to each other. The multiple fixed seats of the multiple implantation needle assemblies are detachably connected to the base, and the auxiliary implantation needle of each implantation needle assembly is respectively connected to one of the flexible microelectrodes;

[0007] The implant manipulation member includes a first magnetic member, and each of the fixing seats includes a second magnetic member. The implant manipulation member is magnetically attracted to the second magnetic member on each fixing seat through the first magnetic member, thereby driving each fixing seat and the corresponding auxiliary implant needle to separate from the base, and realizing the implantation of the corresponding flexible microelectrode into a preset position in the brain region.

[0008] Further, the auxiliary implant needle is a silk fibroin needle, and the auxiliary implant needle and the fixing seat are connected by a bio-soluble glue;

[0009] Alternatively, the auxiliary implant needle is a tungsten needle, and the auxiliary implant needle and the fixing seat are connected by a non-bio-soluble glue.

[0010] Further, a plurality of slot holes are formed in the base, and a plurality of through openings communicating with each slot hole are formed in the side wall of the base. Each fixing seat is inserted into one of the slot holes along a preset direction, and the implant manipulation member drives each fixing seat to separate from the corresponding slot hole along the preset direction.

[0011] Further, the preset direction is the axial direction of the slot hole, and in the axial direction of the slot hole, one end of each fixing seat is connected to the auxiliary implant needle, and a receiving groove is formed at the other end of each fixing seat;

[0012] The second magnetic member is a first magnetic attracting body, and the first magnetic attracting body is fixedly arranged in the receiving groove of the corresponding fixing seat. The implant manipulation member is magnetically attracted to the fixing seat through the first magnetic attracting body.

[0013] Further, the implant needle assembly further includes a cover, and the cover is arranged on the end surface of the base through which a plurality of fixing seats pass. The cover can slide relative to the base to cover a part of the slot holes on the base.

[0014] Further, the plurality of slot holes are arranged in an array on the base along a target direction, and the sliding direction of the cover relative to the base is the same as the target direction.

[0015] Further, each fixing seat is a magnetic body, and each fixing seat is inserted into one of the slot holes along the radial direction of the slot hole through the through opening;

[0016] The second magnetic member is a second magnetic attracting body, and the second magnetic attracting body is fixedly arranged inside each slot hole. In the axial direction of the slot hole, one end of each fixing seat is connected to the auxiliary implant needle, and the other end of each fixing seat is magnetically attracted to the second magnetic attracting body in the corresponding slot hole.

[0017] Further, the implant manipulation member further includes an adjustment column, the first magnetic member is a third magnetic absorber, the third magnetic absorber is connected to the adjustment column, and the adjustment column can adjust the position of the third magnetic absorber to magnetically attract the second magnetic member on each of the fixed seats.

[0018] Further, the implant manipulation member further includes a magnet fixing bracket, the magnet fixing bracket is connected to the end of the adjustment column and can move relative to the adjustment column, and the third magnetic absorber is arranged on the magnet fixing bracket.

[0019] According to another aspect of the present application, there is provided a flexible microelectrode implantation device, which includes:

[0020] The flexible microelectrode implantation device as described above;

[0021] A control circuit board, one end of each of the plurality of flexible microelectrodes is connected to the control circuit board, and the other ends of the plurality of flexible microelectrodes are respectively connected to the corresponding auxiliary implantation needles;

[0022] A fastening mechanism, which is used to position and adjust the relative position of the control circuit board.

[0023] Further, the fastening mechanism includes:

[0024] A locking frame, the fastening mechanism is connected to the base of the flexible microelectrode implantation device through the locking frame, and the locking frame has two opposite fastening parts;

[0025] A locking block, the locking block and the control circuit board are both arranged between the two fastening parts, and the locking block can clamp and fix the control circuit board by adjusting the distance from the adjacent fastening part.

[0026] Further, corresponding threaded holes are formed on the locking block and the adjacent fastening part, and a pin hole is also formed on the locking block, and the pin hole is perpendicular to and communicates with the threaded hole on the locking block;

[0027] The fastening mechanism further includes a modified screw and a pin shaft, an annular groove is formed on the modified screw, the modified screw sequentially passes through the threaded holes on the fastening part and the locking block, and the pin shaft passes through the pin hole and is clamped and engaged in the annular groove.

[0028] Further, the fastening mechanism includes a fastening body, the control circuit board is arranged inside the fastening body, and the material of the fastening body is an elastic material and can apply a clamping force to the control circuit board under the action of an external force.

[0029] Furthermore, the fastening body and the base are integrally processed and formed by 3D printing.

[0030] According to another aspect of the present application, a flexible microelectrode implantation system is provided, which includes:

[0031] The flexible microelectrode implantation device as described above;

[0032] A positioning device, which is connected to the implantation control member and the fastening mechanism of the flexible microelectrode implantation device, and can perform positioning adjustment on the implantation control member and the fastening mechanism.

[0033] Furthermore, the positioning device includes an electromagnet. The positioning device is connected to the implantation control member through the electromagnet, and the electromagnet drives the implantation control member to move through electromagnetic attraction and disconnection.

[0034] The beneficial effects of the present application are:

[0035] By providing a base to pre-fix the multiple fixing seats of the multiple implantation needle assemblies, the auxiliary implantation needles connected to each fixing seat, together with the corresponding flexible microelectrodes, can also be fixed in position relative to the base. Then, through the magnetic attraction between the first magnetic member on the implantation control member and the second magnetic member on each fixing seat, the fixed seat attracted by the magnet and the auxiliary implantation needle thereon are separated from the base, so as to assist the corresponding flexible microelectrode to be implanted into a preset position in the brain region and complete the implantation of a single root. With this setting, when multiple flexible microelectrodes need to be implanted, the implantation control member can be used to individually control each fixing seat, and thus the implantation area and implantation depth of each auxiliary implantation needle can be dynamically selected. And compared with other control methods, this magnetic attraction control method can achieve the rapid implantation of a single root without reducing the implantation efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] In order to more clearly illustrate the technical solutions of the present application, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings in the following description are only the embodiments of the present application. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0037] Figure 1 It is a schematic diagram of the overall structure of the flexible microelectrode implantation device according to Embodiment 1 of the present application.

[0038] Figure 2 It is an exploded schematic diagram of the overall structure of the flexible microelectrode implantation device according to Embodiment 1 of the present application.

[0039] Figure 3 Schematic diagram of the structure of the flexible microelectrode implantation device according to Embodiment 1 of the present application at the position of the implantation needle assembly.

[0040] Figure 4 Schematic diagram (I) of the structure of the base in the flexible microelectrode implantation device according to Embodiment 1 of the present application.

[0041] Figure 5 Schematic diagram (II) of the structure of the base in the flexible microelectrode implantation device according to Embodiment 1 of the present application.

[0042] Figure 6 Schematic diagram of the structure of the cover in the flexible microelectrode implantation device according to Embodiment 1 of the present application.

[0043] Figure 7 Schematic diagram of the assembly structure of four fixing seats and four auxiliary implantation needles in the flexible microelectrode implantation device according to Embodiment 1 of the present application.

[0044] Figure 8 Schematic diagram of the structure of the fixing seat in the flexible microelectrode implantation device according to Embodiment 1 of the present application.

[0045] Figure 9 Schematic diagram of the structure of the implantation control member in the flexible microelectrode implantation device according to Embodiment 1 of the present application.

[0046] Figure 10 Schematic diagram of the connection between the control circuit board and the flexible microelectrode according to Embodiment 1 of the present application.

[0047] Figure 11 Schematic diagram of the structure of the flexible microelectrode implantation device according to Embodiment 1 of the present application at the position of the fastening mechanism.

[0048] Figure 12 Schematic diagram of the structure of the locking frame in the fastening mechanism according to Embodiment 1 of the present application.

[0049] Figure 13 Schematic diagram of the structure of the locking block in the fastening mechanism according to Embodiment 1 of the present application.

[0050] Figure 14 Schematic diagram of the structure of the modified screw in the fastening mechanism according to Embodiment 1 of the present application.

[0051] Figure 15 Schematic diagram of the assembly structure of four fixing seats and four auxiliary implantation needles in the flexible microelectrode implantation device according to Embodiment 2 of the present application.

[0052] Figure 16 Schematic diagram of the overall structure of the flexible microelectrode implantation device according to Embodiment 2 of the present application.

[0053] Figure 17Explosion schematic diagram of the overall structure of the flexible microelectrode implantation device according to Embodiment 3 of the present application.

[0054] Figure 18 Schematic assembly structure diagram of the base and fastening mechanism according to Embodiment 3 of the present application.

[0055] Figure 19 Schematic assembly structure diagram of four fixing seats and four auxiliary implantation needles in the flexible microelectrode implantation device according to Embodiment 3 of the present application.

[0056] Figure 20 Schematic assembly structure diagram of the flexible microelectrode implantation device, quick-change part and electromagnet according to Embodiment 3 of the present application.

[0057] Figure 21 Schematic assembly structure diagram of the quick-change part and the electromagnet according to Embodiment 3 of the present application.

[0058] Figure 22 Explosion diagram of the structure of the flexible microelectrode implantation device at the fastening mechanism position according to Embodiment 4 of the present application.

[0059] Figure 23 Schematic diagram (1) of the structure of the flexible microelectrode device at the fastening mechanism position according to Embodiment 4 of the present application.

[0060] Figure 24 Schematic diagram (2) of the structure of the flexible microelectrode device at the fastening mechanism position according to Embodiment 4 of the present application.

[0061] Among them, the corresponding reference numerals in the figure are: base - 1, slot hole - 11, guide block - 12, adjustment hole - 13, second fastening hole - 14, implantation needle assembly - 2, cover - 21, adjustment screw - 211, guide groove - 212, sliding groove - 213, fixing seat - 22, first magnetic body - 221, receiving groove - 222, auxiliary implantation needle - 23, fixing column - 3, flexible microelectrode - 4, magnet fixing frame - 51, adjustment column - 52, third magnetic body - 53, locking frame - 61, locking part - 611, convex part - 612, threaded hole - 613, column mounting hole - 614, locking screw mounting hole - 615, first fastening hole - 616, guide hole - 617, locking block - 62, fixing protrusion - 621, pin hole - 622, modified screw - 63, annular groove - 631, guide screw - 64, pin shaft - 65, fastening screw - 66, fastening body - 67, insertion groove - 671, first clamping screw - 672, second clamping screw - 673, control circuit board - 7, electromagnet - 8, quick-change part - 9. Detailed implementation manner

[0062] The following will be combined with the drawings in this application to clearly and completely describe the technical solutions in the embodiments of this application. Obviously, the described embodiments are only part of the embodiments of this application, not all of them. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0063] Example 1

[0064] like Figure 1 and Figure 2 As shown, this embodiment provides a flexible microelectrode implantation device including a flexible microelectrode implantation device. In addition to the flexible microelectrode implantation device, the flexible microelectrode implantation device also includes a fastening mechanism and a control circuit board 7. The fastening mechanism mainly includes a fastening frame 61 and a fastening block 62. The flexible microelectrode implantation device is described in detail below.

[0065] like Figures 1 - 3 As shown, the flexible microelectrode implantation device mainly includes a base 1, four implantation needle assemblies 2, four flexible microelectrodes 4 and an implantation control member, and the implantation control member mainly includes a magnet fixing frame 51, an adjustment column 52 and a first magnetic member (third magnetic body 53). Each implantation needle assembly 2 includes a fixing seat 22 and an auxiliary implantation needle 23 connected to each other. When the number of implantation needle assemblies 2 is set to four, the number of corresponding fixing seats 22 and auxiliary implantation needles 23 is also four respectively. These fixing seats 22 can be detachably connected to the base 1, and each auxiliary implantation needle 23 is respectively connected to one of the flexible microelectrodes 4. The first magnetic member in the implantation control member is specifically the third magnetic body 53 in this embodiment, and each fixing seat 22 includes a second magnetic member. In this embodiment, the second magnetic member is specifically the first magnetic body 221. It should be noted that the magnetic body mentioned in this embodiment mainly refers to an object with magnetic force, which is used to absorb and fix magnetic bodies such as iron, cobalt, and nickel. The implant control member is magnetically attracted to the first magnetic body 221 on each fixing seat 22 through the third magnetic body 53, thereby driving each fixing seat 22 and the corresponding auxiliary implant needle 23 to be separated from the base 1, so that the corresponding flexible microelectrode 4 is implanted into the preset position of the brain area.

[0066] By setting the base 1 to pre-fix the four fixing seats 22 of the four implanting needle assemblies 2, the auxiliary implanting needles 23 connected to each fixing seat 22 can also drive the corresponding flexible microelectrodes 4 to be fixed relative to the base 1. Then, the third magnet 53 on the implanting control member is magnetically attracted to the first magnet 221 on each fixing seat 22, so that the magnetically attracted fixing seat 22 together with the auxiliary implanting needle 23 thereon is separated from the base 1, and the fixing seat 22 is driven to reach the preset position in the brain area for implanting the auxiliary implanting needle 23. When the auxiliary implanting needle 23 is implanted, it can drive the corresponding flexible microelectrode 4 to be implanted into the preset position in the brain area, completing the implantation of a single flexible microelectrode 4. With this setting, when multiple flexible microelectrodes 4 need to be implanted, the implanting control member can be used to individually control each fixing seat 22, and thus the implantation area and depth of each auxiliary implanting needle 23 can be dynamically selected. Moreover, compared with other control methods, this magnetic attraction control method can achieve rapid implantation of a single root and will not reduce the implantation efficiency.

[0067] In this embodiment, the number settings of the implanting needle assembly 2 and the flexible microelectrode 4 are only exemplary. In other alternative embodiments, the numbers of the implanting needle assembly 2 and the flexible microelectrode 4 can be fully adjusted according to actual needs. In addition, the numbers of the implanting needle assembly 2 and the flexible microelectrode 4 may not be equal. For example, five implanting needle assemblies 2 are provided on the base 1, while only four flexible microelectrodes 4 need to be implanted. Then, the extra implanting needle assembly 2 can remain on the base 1 without affecting the implantation of the flexible microelectrode 4. Or, three implanting needle assemblies 2 are provided on the base 1, while four flexible microelectrodes 4 need to be implanted. Then, three of them can be implanted first using the three implanting needle assemblies 2, and then the implanting needle assembly 2 can be continued to be installed on the base 1 to continue implanting the remaining flexible microelectrodes 4.

[0068] In addition, in this embodiment, the third magnet 53 is used as the first magnetic member, and the first magnet 221 is used as the second magnetic member. Both have a certain suction force, making the magnetic attraction more stable when the fixing seat 22 is taken out using the implanting control member, thereby improving the stability of the operation. However, in other alternative embodiments, it is entirely possible to only set one magnet, and the other is set as a magnetic member, as long as the two can be magnetically attracted to each other.

[0069] In this embodiment, the auxiliary implant needle 23 specifically adopts a silk protein needle, and in each implant needle assembly 2, the auxiliary implant needle 23 is connected to the corresponding fixing seat 22 by a biosoluble glue such as protein glue. With this arrangement, when each auxiliary implant needle 23 is implanted using the fixing seat 22, the auxiliary implant needle 23 can be self-degraded in the brain area, and the auxiliary implant needle 23 can be detached from the fixing seat 22 by itself, avoiding the need to remove the auxiliary implant needle 23 after assisting the corresponding flexible microelectrode 4 to be implanted in the brain area, reducing the risk of implantation failure and reducing secondary damage to brain tissue.

[0070] like Figure 4 and Figure 5 As shown, four slots 11 are provided on the base 1 of the flexible microelectrode implantation device, and the slotting directions of the four slots 11 are consistent. Four through openings are provided on the side wall of the base 1, which are connected to each slot 11 respectively. Each through opening is connected to the corresponding slot 11 to form a receiving groove 222 with an approximately "U-shaped" cross-section. A sealing plate support is provided at the bottom of each slot 11, and the base 1 is also provided with a bayonet structure at the position corresponding to each through opening. Each fixing seat 22 is inserted into one of the slots 11 along a preset direction. The sealing plate support and the bayonet structure can prevent the fixing seat 22 from falling from the bottom and side of the slot 11. At this time, the implant control member can drive each fixing seat 22 to detach from the corresponding slot 11 along the preset direction.

[0071] By inserting each fixing seat 22 into the slot 11 on the fixing seat 22 along a preset direction, the stability of the fixing seat 22 relative to the base 1 can be improved. A plurality of through openings connected to each slot 11 are provided on the side wall of the base 1 to facilitate the insertion and removal of the auxiliary implant needle 23 and the flexible microelectrode 4 after the fixing seat 22 is removed. At the same time, the insertion direction of the fixing seat 22 relative to the base 1 is set to limit the fixing seat 22 from being separated from the base 1 in other directions, so that when the multiple fixing seats 22 are magnetically sucked out by using the implant control member, a fixed moving path can be provided, which is more convenient and more efficient.

[0072] like Figure 7 and Figure 8As shown, the overall structure of each fixing base 22 is a cylindrical structure. The direction in which the fixing base 22 penetrates the slot hole 11 is the axial direction of the slot hole 11, that is, the axial direction of the fixing base 22. In the axial direction of the slot hole 11, one end of each fixing base 22 is connected to the auxiliary implanting needle 23, and a receiving groove 222 is formed at the other end of each fixing base 22. The first magnetic body 221 is fixedly arranged in the receiving groove 222 of each fixing base 22. The third magnetic body 53 of the implanting control member is magnetically attracted to each fixing base 22 through each first magnetic body 221. By setting the penetrating direction of the fixing base 22 relative to the base 1 as the axial direction of the slot hole 11, when the fixing base 22 penetrates and moves relative to the base 1, the fixing base 22 can drive the auxiliary implanting needle 23 at the end of its axial direction to move and move out of the base 1 through the through opening, avoiding interference with the base 1. At the same time, a receiving groove 222 is formed at the other end far from the auxiliary implanting needle 23, and the first magnetic member is fixedly arranged in the receiving groove 222, so that the implanting control member can be magnetically attracted to the first magnetic member, thereby driving the fixing base 22 to move away from the base 1, which is more convenient and reliable in operation.

[0073] Furthermore, for the receiving groove 222 formed on the fixing base 22, its depth dimension satisfies that when the first magnetic body 221 is fixedly arranged in the receiving groove 222, there is a certain distance between the top of the first magnetic body 221 and the top of the fixing base 22. This distance dimension can be adjusted according to the size and strength of the first magnetic body 221. A preferable setting is between 0.3 mm and 0.5 mm, so as to form a groove space between the first magnetic body 221 and the fixing base 22. This groove space has a guiding function. When the third magnetic body 53 is magnetically attracted to the first magnetic body 221, the third magnetic body 53 can use this groove space for guiding, so that the third magnetic body 53 and the first magnetic body 221 will not move when magnetically attracted to each other, thereby avoiding affecting the implantation of the auxiliary implanting needle 23. The first magnetic member can be fixed in the receiving groove 222 by liquid glue, double-sided tape, screws or dimensional tolerance matching.

[0074] As Figure 3 and Figure 6As shown, the auxiliary needle assembly further includes a cover 21. The cover 21 is disposed on the end surface of the base 1 through which a plurality of fixing seats 22 pass. Since the overall structure of the cover 21 is an L-shaped structure, the cover 21 is also disposed on the adjacent end surface of the base 1 through which a plurality of fixing seats 22 pass. The cover 21 can slide relative to the base 1 to cover a part of the slot holes 11 on the base 1. When a first magnetic body 221 is disposed at the end of each fixing seat 22 in the axial direction, by disposing the cover 21 on the end surface of the base 1 through which a plurality of fixing seats 22 pass, and using the sliding of the cover 21 relative to the base 1, a part of the slot holes 11 on the base 1 are covered; through this setting, whether a plurality of fixing seats 22 are installed in a plurality of slot holes 11 of the base 1 before the implantation operation, or each fixing seat 22 is taken out by using an implantation control member during the implantation process, the cover 21 can be used to cover a part of the slot holes 11 or the fixing seats 22 in real time, avoiding the mutual attraction of the first magnetic members on the plurality of fixing seats 22 and improving the reliability of the implantation process.

[0075] Furthermore, the plurality of slot holes 11 on the base 1 are arranged in an array along the target direction on the base 1, and the sliding direction of the cover 21 relative to the base 1 is the same as the target direction. For details, reference can be made to Figure 3 As shown, the dashed-line structure in the figure is the cover 21. When four slot holes 11 are arranged in an array along the horizontal left-right direction on the base 1, the sliding direction of the cover 21 relative to the base 1 is the horizontal left-right direction. Through this setting, when a plurality of fixing seats 22 are installed on the base 1 or a plurality of fixing seats 22 are taken out from the base 1 one by one, the installation or removal can be performed along the sliding direction of the cover 21. During this process, the cover 21 can be slid along the sliding direction to gradually cover or uncover the plurality of fixing seats 22, more effectively avoiding the mutual attraction of the first magnetic members on the adjacent fixing seats 22, and the operation is also more convenient. However, it should be noted that in other alternative embodiments, the arrangement of the plurality of slot holes 11 on the base 1 may not be arranged in an array along the target direction, and the sliding direction of the cover 21 relative to the base 1 may not be the same as the target direction, and can be adjusted according to actual needs without fixed restrictions.

[0076] In addition, as Figures 4 - 6As shown, in order to cooperate with the sliding and fixing of the cover 21 on the base 1, the base 1 is further provided with a guiding block 12 on the side wall adjacent to the slot 11, and an adjusting hole 13 is provided on the top wall of the base 1. To cooperate with the setting of the guiding block 12 and the adjusting hole 13, the cover 21 is respectively provided with a guiding groove 212 and a sliding groove 213 on the corresponding side surfaces. When the cover 21 is arranged on the base 1, the guiding block 12 is accommodated in the guiding groove 212 and can move along the extending direction of the guiding groove 212, thereby restricting the moving path of the cover 21 relative to the base 1. At the same time, after the movement is completed, the adjusting screw 211 can be passed through the sliding groove 213 on the cover 21 and distributedly connected with the adjusting hole 13 to fix the cover 21 relative to the base 1. In addition, the setting of the guiding block 12 and the guiding groove 212 can also cause the cover 21 to shake during the sliding process, affecting the stability during the operation process. In other alternative embodiments, the material of the cover 21 and the matching dimensions of the frame and the base 1 can be replaced to enable the cover 21 to slide smoothly.

[0077] As Figure 1 and Figure 9 shown, the implant manipulation part in the flexible microelectrode implantation device further includes an adjustment column 52 and a magnet fixing bracket 51 in addition to the third magnetic body 53. The third magnetic body 53 is connected to the adjustment column 52, and the adjustment column 52 can adjust the position of the third magnetic body 53 to enable the third magnetic body 53 to magnetically attract the first magnetic body 221 on each fixing seat 22. Through this setting, the moving range of the third magnetic body 53 can be increased, which is more convenient for magnetically attracting the first magnetic body 221 on the fixing seat 22. At the same time, it is also convenient to adjust the position of each fixing seat 22 so that it reaches the preset position in the brain area after being separated from the base 1, realizing rapid and accurate implantation. Further, the magnet fixing bracket 51 of the implant manipulation part is connected to the end of the adjustment column 52 and can move relative to the adjustment column 52. The third magnetic body 53 is arranged on the magnet fixing bracket 51, further increasing the moving flexibility of the third magnetic body 53, and thus being more convenient for magnetically attracting each other with the first magnetic body 221, thereby driving the fixing seat 22 to reach the preset position in the brain area. At the same time, through the setting of the magnet fixing bracket 51, the interference between the adjustment column 52 and the base 1 can also be reduced, avoiding collision during the operation process, and improving the reliability of the implantation process.

[0078] As described above, in this embodiment, the flexible microelectrode implantation device further includes a fastening mechanism and a control circuit board 7 in addition to the flexible microelectrode implantation device. As Figure 1 、 Figure 2 and Figure 10As shown, by providing a control circuit board 7, one end of each of the four flexible microelectrodes 4 is connected to the control circuit board 7, and the other ends of the four flexible microelectrodes 4 are respectively connected to corresponding auxiliary implantation needles 23, so as to use the control circuit board 7 to fix these flexible microelectrodes 4 and output signals. In addition, in combination with Figure 11 As shown, the fastening mechanism mainly includes a fastening frame 61 and a fastening block 62. The control circuit board 7 and the fastening block 62 are cooperated with each other and fixed on the fastening frame 61. The relative position of the control circuit board 7 is positioned and adjusted by the fastening mechanism, so as to adjust and position the control circuit board 7 as required during the implantation process of the flexible microelectrodes 4, and ensure the stability during the implantation process of multiple flexible microelectrodes 4.

[0079] As Figure 12 and Figure 13 shown, a first fastening hole 616 is formed in the fastening frame 61 of the fastening mechanism, and a second fastening hole 14 corresponding to the first fastening hole 616 is formed in the base 1. A fastening screw 66 sequentially passes through and is connected to the first fastening hole 616 and the second fastening hole 14 to connect the fastening frame 61 to the base 1. At the same time, the fastening frame 61 further has two oppositely arranged fastening portions 611, and a space in the shape of a "U" is formed between the two fastening portions 611. The fastening block 62 and the control circuit board 7 are both arranged between the two fastening portions 611, and the fastening block 62 realizes the clamping and fixing of the control circuit board 7 by adjusting the distance from the adjacent fastening portion 611. Through this kind of setting, the fastening mechanism is connected to the base 1 of the flexible microelectrode implantation device through the fastening frame 61, so that the fastening mechanism and the flexible microelectrode implantation device can be relatively fixed, improving the stability of the entire device. At the same time, the fastening block 62 and the control circuit board 7 are both arranged between the two fastening portions 611 of the fastening frame 61. By adjusting the distance between the fastening block 62 and the fastening portion 611, the clamping and fixing of the control circuit board 7 are realized, which is more convenient in operation, and at the same time, the clamping force on the control circuit board 7 can be more uniform and more stable.

[0080] Specifically, threaded holes 613 and guide holes 617 are correspondingly formed in the fastening block 62 and the adjacent fastening portion 611. Two pin holes 622 are formed in the fastening block 62, and the two pin holes 622 are perpendicular to and communicate with the threaded hole 613 in the fastening block 62. The fastening mechanism further includes a modified screw 63, a guide screw 64 and a pin shaft 65. The two guide screws 64 respectively pass through the corresponding guide holes 617 in the fastening block 62 and the adjacent fastening portion 611 to realize the positioning between the fastening block 62 and the fastening portion 611. In combination with Figure 14As shown, an annular groove 631 is formed at the end of the modified screw 63. The modified screw 63 sequentially passes through the threaded hole 613 in the fastening portion 611 and the fastening block 62. Two pin shafts 65 respectively pass through the pin holes 622 and are fitted and clamped in the annular groove 631. Through this setting, the modified screw 63 in the fastening mechanism passes through the threaded holes 613 in the fastening portion 611 and the fastening block 62 to achieve the preliminary fixation between the fastening frame 61 and the fastening block 62. Then, the pin shaft 65 passes through the pin hole 622 in the fastening block 62 and is clamped in the annular groove 631 of the modified screw 63. Since the pin hole 622 in the fastening block 62 is perpendicular to the threaded hole 613, when the modified screw 63 is rotated in and out, the fastening block 62 can be driven to move relative to the fastening frame 61, thereby adjusting the distance between the two, realizing the clamping and loosening of the control circuit board 7, and the fastening block 62 will not break away from the fastening frame 61, with a reliable structure and convenient operation.

[0081] In addition, as Figures 10 - 13 shown, a convex portion 612 and a fixed convex 621 are respectively provided on the fastening frame 61 and the fastening block 62, so that when the control circuit board 7 is clamped, the convex portion 612 and the fixed convex 621 are used to clamp only the non-signal transmission area of the control circuit board 7, avoiding affecting the self-function of the control circuit board 7. At the same time, the convex portion 612 and the fixed convex 621 are respectively provided on the fastening frame 61 and the fastening block 62, which can meet the forward and reverse clamping of the control circuit board 7, avoiding damage to the control circuit board 7 caused by incorrect installation direction.

[0082] In addition, this embodiment also provides a flexible microelectrode implantation system, which includes the flexible microelectrode implantation device and the positioning device as described above. As Figure 1 、 Figure 9 and Figure 11As shown in the figure, the flexible microelectrode implantation device includes a fixed column 3 and an adjustment column 52. Among them, the adjustment column 52 is connected to the magnet fixing bracket 51, and the fixed column 3 is connected to the locking bracket 61. The locking bracket 61 is provided with a column mounting hole 614 and a locking screw mounting hole 615. By connecting the end of the fixed column 3 into the column mounting hole 614 and then passing a screw through the locking screw mounting hole 615 and connecting it to the end of the fixed column 3, the fixed column 3 can be stably connected to the locking bracket 61. This positioning device is connected to the fixed column 3 and the adjustment column 52, and in the form of controlling the fixed column 3 and the adjustment column 52, thereby realizing the implantation of the auxiliary implantation needle 23 and the flexible microelectrode 4. It should be noted that this positioning device can be a manual device or an automatic control device existing in the prior art, such as a double-arm stereotactic apparatus for the brain, to achieve automated implantation. By setting the positioning device to perform positioning adjustment on the fixed column 3 and the adjustment column 52 of the microelectrode implantation device, and then realizing the positioning adjustment of the implantation control member and the fastening mechanism, it is more convenient to control the multiple implantation needle assemblies 2 and the implantation control member during the actual implantation process, and thus realize the automatic or manual positioning adjustment of the microelectrode implantation device.

[0083] The following briefly describes the entire operation process for better understanding of the above content. However, this operation process is only an exemplary description and is not absolutely unchangeable or the best operation process.

[0084] First, the implantation needle assembly 2 formed by mating the fixed seat 22 and the auxiliary implantation needle 23 is sequentially fixed within the manipulation of the base 1. When the implantation needle assembly 2 is installed in the slot hole 11, it is loaded in sequence along the fixed direction, for example, installed from left to right in sequence. After each implantation needle assembly 2 is loaded, the sliding cover 21 is slid to cover it to prevent interference with the already installed implantation needle assembly 2 when the second one is loaded, causing the already installed implantation needle assembly 2 to detach from the base 1 or the second implantation needle assembly 2 to be inconvenient to install.

[0085] Second, the control circuit board 7 together with multiple flexible microelectrodes 4 is fixed on the locking bracket 61 of the fastening mechanism, and the base 1 is fixed on the side of the locking bracket 61.

[0086] Third, under the microscope, the ends of the flexible microelectrodes 4 connected to the control circuit board 7 are sequentially fixed to the ends of the auxiliary protein needles.

[0087] Fourth, the fixed column 3 and the adjustment column 52 are respectively fixed on the double-arm stereotactic apparatus for the brain. According to the different brain regions to be implanted, the stereotactic apparatus is adjusted to reach the vicinity of the corresponding brain region. The third magnetic body 53 on the implantation control member magnetically attracts the first magnetic body 221 on each fixed seat 22, and then it is moved to the implanted brain region and implanted.

[0088] Fifth, the flexible microelectrode 4 is implanted into the brain tissue driven by the auxiliary implantation needle 23. The auxiliary implantation needle 23 is dissolved by physiological saline, and the implantation and detachment of multiple auxiliary implantation needles 23 are completed in sequence. The order in which the third magnet 53 magnetically attracts the implantation needle assembly 2 is opposite to the order in which the implantation needle assembly 2 is installed on the base 1. For example, when the implantation needle assembly 2 is installed in the slot 11, it is installed in sequence from left to right along the base 1. At this time, the order in which the third magnet 53 magnetically attracts the implantation needle assembly 2 to remove it from the base 1 is from right to left along the base 1. When removing the first implantation needle assembly 2, the fixing seat 22 of the adjacent implantation needle assembly 2 is covered with the cover 21 to prevent it from being affected by magnetism. After each implantation is completed, the fixing seat 22 can be manually removed and placed in the waste box.

[0089] Sixth, after all implantations are completed, the control circuit board 7 is fixed with dental cement.

[0090] Seventh, rotate the modified screw 63 to loosen the locking block 62 so that it is disengaged from the control circuit board 7.

[0091] Embodiment 2

[0092] This embodiment also provides a flexible microelectrode implantation device, as well as a flexible microelectrode implantation device and a flexible microelectrode implantation system including the same. The flexible microelectrode implantation device in this embodiment is basically the same as the flexible microelectrode implantation device in Embodiment 1. Only the differences will be elaborated in detail below. The reference numerals in this embodiment can refer to the corresponding reference numerals in Embodiment 1.

[0093] In this embodiment, the implanting needle assembly 2 includes a fixing base 22 and an auxiliary implanting needle 23. The fixing base 22 is still placed in the slot 11 of the base 1. However, in this embodiment, the direction in which the fixing base 22 penetrates the base 1 is the radial direction of the slot 11, that is, each fixing base 22 is penetrated in one of the slots 11 along the radial direction of the slot 11 through a through opening communicating with the slot 11. At the same time, one end of the fixing base 22 in its axial direction is connected to the auxiliary implanting needle 23, and the other end of the fixing base 22 in its axial direction is not provided with a receiving groove 222, but the fixing base 22 itself is set as a magnetic body that can be magnetically attracted. The second magnetic member on each fixing base 22 specifically uses a second magnetic attracting body, and the second magnetic attracting body is fixedly arranged in each slot 11, that is, the position of the second magnetic attracting body relative to the slot 11 is fixed. When the fixing base 22 is placed in the slot 11, it can be magnetically attracted by the second magnetic attracting body and relatively fixed. When it is necessary to first take out the fixing base 22 from the slot 11 of the base 1, the third magnetic attracting body 53 of the implanting control member can be directly magnetically attracted to the fixing base 22 to separate the fixing base 22 from the corresponding second magnetic attracting body, so as to realize taking out the fixing base 22 and the auxiliary implanting needle 23 thereon from the slot 11 of the base 1. In addition, a silica gel pad is further arranged between the second magnetic attracting body and the fixing base 22 to adjust the magnetic attraction force of the second magnetic attracting body relative to the fixing base 22. The silica gel pad can be fixed on the second magnetic attracting body by back glue or other glues, so that the third magnetic attracting body 53 can more easily magnetically attract the fixing base 22 and take it out.

[0094] Through the above setting in this embodiment, the second magnetic attracting body is fixedly arranged in the corresponding slot 11. Even if the cover 21 is not provided, it can avoid the mutual interference between the second magnetic attracting bodies during the installation and removal of the fixing base 22, with a simpler structure, more reliable and convenient operation.

[0095] Furthermore, as Figure 15 shown, since the fixing base 22 directly uses a magnetic body in this embodiment, and the direction in which the fixing base 22 penetrates the base 1 is the radial direction of the slot 11, the auxiliary implanting needle 23 is connected to the lower side of the corresponding fixing base 22, and the fixing base 22 is internally chamfered at the position where the auxiliary implanting needle 23 is connected. The chamfering depth is determined according to the thickness of the auxiliary implanting needle 23, so that when the auxiliary implanting needle 23 fits on the fixing base 22, the outer surface of the fixing base 22 can be flush, which is convenient for the third magnetic attracting body 53 of the implanting control member to better magnetically attract the side surface of the fixing base 22; at the same time, this way of magnetically attracting from the side surface of the fixing base 22 has a larger contact area, greater magnetic attraction force, and is easier to maintain stability.

[0096] Embodiment 3

[0097] This embodiment also provides a flexible microelectrode implantation device, and a flexible microelectrode implantation apparatus and a flexible microelectrode implantation system comprising the same. The flexible microelectrode implantation apparatus in this embodiment is substantially the same as the flexible microelectrode implantation apparatus in Example 1, and only the differences are described in detail below. The reference numerals in this embodiment may refer to the corresponding reference numerals in Example 1.

[0098] like Figure 16 and Figure 17 As shown, the fastening mechanism in this embodiment specifically includes a fastening body 67, the material of the fastening body 67 is an elastic material such as polyurethane, and the control circuit board 7 is inserted into the fastening body 67. The fastening body 67 can apply a clamping force to the control circuit board 7 under the action of an external force, so that the control circuit board 7 is fixed relative to the fastening body 67. Specifically, the implantation control component of the flexible microelectrode implantation device directly sets the third magnetic body 53 at the end of the adjustment column 52, so as to directly control the third magnetic body 53 by using the adjustment column 52. Figure 18 As shown, the base 1 of the flexible microelectrode implant device is directly integrated with the fastening body 67 by 3D printing to reduce the number of machined parts, reduce production costs, and facilitate assembly. At the same time, the fastening body 67 of elastic material is in direct contact with the control circuit board 7, which can also reduce damage to the control circuit board 7, and in actual operation, the hardness of polyurethane can be adjusted as needed.

[0099] Specifically, the fixing column 3 is connected to the fastening body 67, and the control circuit board 7 is inserted into the fastening body 67 through the insertion slot 671, and then the second clamping screw 673 outside the fastening body 67 is matched with the first clamping screw 672 inside the fastening body 67 to fix the control circuit board 7. At the same time, a slot 11 is provided on the base 1 integrally provided with the fastening body 67, and the fixing seats 22 of the implant needle assembly 2 are respectively inserted into the slot 11, and the fixing seats 22 are connected to the auxiliary implant needles 23, and the flexible microelectrode 4 connected to the control circuit board 7 is connected to the corresponding auxiliary implant needles 23. The third magnetic body 53 is controlled by the adjustment column 52 to magnetically attract each fixing seat 22, so that it drives the corresponding auxiliary implant needle 23 to detach from the slot 11 of the base 1, so that the corresponding flexible microelectrode 4 is implanted into the preset position of the brain area.

[0100] In addition, if Figure 19As shown, in this embodiment, the auxiliary implantation needle 23 is a tungsten needle. The auxiliary implantation needle 23 is directly inserted into the fixing base 22, and the auxiliary implantation needle 23 and the fixing base 22 are connected by a non-bio-soluble glue. Through this setting, when using the fixing base 22 to assist in implanting each auxiliary implantation needle 23, the connection between the auxiliary implantation needle 23 and the fixing base 22 is tighter, avoiding the auxiliary implantation needle 23 detaching from the fixing base 22 during the implantation process and when removing the auxiliary implantation needle 23 using the fixing base 22, and improving the stability and reliability of the implantation.

[0101] Since the auxiliary implantation needle 23 in this embodiment is a tungsten needle, after using the tungsten needle to assist in implanting the flexible microelectrode 4, the tungsten needle needs to be pulled out. Therefore, the positioning device in the flexible microelectrode implantation system of this embodiment further includes a quick-change part 9 and an electromagnet 8, as Figure 20 and Figure 21 shown. The electromagnet 8 is connected to the main body of the positioning device through the quick-change part 9. At the same time, the electromagnet 8 is connected to the adjustment column 52 of the implantation control part. The electromagnet 8 drives the implantation control part to move through electromagnetic attraction and disconnection. By setting the electromagnet 8 on the positioning device, and connecting the electromagnet 8 to the adjustment column 52 of the implantation control part, the implantation control part can drive the implantation control part to move quickly through electromagnetic attraction and disconnection, which is more convenient for implanting the auxiliary implantation needle 23 and the flexible microelectrode 4. At the same time, when it is necessary to pull out the auxiliary implantation needle 23, it can also be quickly operated to avoid secondary damage to the brain tissue during the process of pulling out the auxiliary implantation needle 23. However, it should be noted that in other alternative embodiments, even if the auxiliary implantation needle 23 is a silk fibroin needle, the electromagnet 8 and the quick-change part 9 can also be set in the positioning device to achieve the rapid implantation of the auxiliary implantation needle 23 driving the flexible microelectrode 4.

[0102] Embodiment 4

[0103] This embodiment also provides a flexible microelectrode implantation device, as well as a flexible microelectrode implantation device and a flexible microelectrode implantation system including the same. The flexible microelectrode implantation device in this embodiment is basically the same as the flexible microelectrode implantation device in Embodiment 3. Only the differences will be elaborated in detail below. The reference numerals in this embodiment can refer to the corresponding reference numerals in Embodiment 1.

[0104] As Figure 22 、 Figure 23 and Figure 24As shown in the figure, in this embodiment, the fastening mechanism 6 specifically includes a fastening body 67. The fastening body 67 is an integral structure. The fixed column 3 is connected to one end surface in the axial direction of the fastening body 67. The control circuit board 7 is inserted and fixed into the fastening body 67 along the other end surface in the axial direction of the fastening body 67. One end of the control circuit board 7 extending out of the fastening body 67 is connected with a plurality of flexible microelectrodes 4. Four slot holes are formed on the side wall of the fastening body 67. The four fixing seats 22 corresponding to the implanting needle assembly 2 are respectively placed in the corresponding slot holes along the radial direction of the fastening body 67, that is, the fixing seats 22 can move from the side of the fastening body 67. When the fixing seats 22 are placed in the slot holes, an adhesive with appropriate viscosity can be used for fixation to prevent the fixing seats 22 from easily detaching from the fastening body 67. Moreover, the fastening body 67 is provided with an opening for the auxiliary protein needle 23 to move in or out corresponding to each slot hole. Each fixing seat 22 is connected with an auxiliary protein needle 23 and drives the auxiliary protein needle 23 to move synchronously. The flexible microelectrodes 4 connected to the control circuit board 7 are respectively connected with the auxiliary protein needles 23. When the fixing seats 22 are moved by the magnetic body to be detached from the fastening body 67, the auxiliary protein needles 23 on the fixing seats 22 can drive the flexible microelectrodes 4 to move and be implanted into the preset position in the brain region according to the operation of the operator. And the collective setting of this structure makes the overall structure more compact and the operation more convenient.

[0105] The embodiments of the present application have been described above. The above description is exemplary and not exhaustive, and is not limited to the disclosed embodiments. Many modifications and variations are obvious to those of ordinary skill in the art in the technical field without departing from the scope and spirit of the described embodiments. The selection of the terms used herein is intended to best explain the principles of the embodiments, the practical application or the improvement of the technology in the market, or to enable other ordinary skill in the art in the technical field to understand the disclosed embodiments.

Claims

1. A flexible microelectrode implantation device, characterized in that It includes a base (1), a plurality of implant needle assemblies (2), a plurality of flexible microelectrodes (4), and an implant control member; Each of the implant needle assemblies (2) includes a fixed seat (22) and an auxiliary implant needle (23) connected to each other. The fixed seats (22) of the plurality of implant needle assemblies (2) are detachably connected to the base (1). The auxiliary implant needle (23) of each implant needle assembly (2) is respectively connected to one of the flexible microelectrodes (4); The implant control member includes a first magnetic member. Each fixed seat (22) includes a second magnetic member. The implant control member is magnetically attracted to the second magnetic member on each fixed seat (22) through the first magnetic member, thereby driving each fixed seat (22) and the corresponding auxiliary implant needle (23) to disengage from the base (1), so as to implant the corresponding flexible microelectrode (4) into a preset position in the brain region; A plurality of slot holes (11) are formed in the base (1), and a plurality of through openings communicating with each slot hole (11) are formed on the side wall of the base (1). Each fixed seat (22) is inserted into one of the slot holes (11) along a preset direction. The implant control member drives each fixed seat (22) to disengage from the corresponding slot hole (11) along the preset direction; One end of each fixed seat (22) is connected to the auxiliary implant needle (23).

2. The flexible microelectrode implantation device according to claim 1, wherein The auxiliary implant needle (23) is a silk fibroin needle, and the auxiliary implant needle (23) is connected to the fixed seat (22) through a bio-soluble glue; Alternatively, the auxiliary implant needle (23) is a tungsten needle, and the auxiliary implant needle (23) is connected to the fixed seat (22) through a non-bio-soluble glue.

3. The flexible microelectrode implantation device according to claim 1, characterized in that The preset direction is the axial direction of the slot hole (11), and in the axial direction of the slot hole (11), a receiving groove (222) is formed at the other end of each fixed seat (22); The second magnetic member is a first magnetic body (221). The first magnetic body (221) is fixedly arranged in the receiving groove (222) of the corresponding fixed seat (22). The implant control member is magnetically attracted to the fixed seat (22) through the first magnetic body (221).

4. The flexible microelectrode implantation device according to claim 3, wherein The implant needle assembly (2) further includes a cover (21). The cover (21) is arranged on the end surface of the base (1) through which the plurality of fixed seats (22) pass. The cover (21) can slide relative to the base (1) to cover a part of the slot holes (11) on the base (1).

5. The flexible microelectrode implantation device according to claim 4, wherein The plurality of slot holes (11) are arranged in an array on the base (1) along a target direction, and the sliding direction of the cover (21) relative to the base (1) is the same as the target direction.

6. The flexible microelectrode implantation device according to claim 2, characterized in that Each fixed seat (22) is a magnetic body, and each fixed seat (22) is inserted into one of the slot holes (11) along the radial direction of the slot hole (11) through the through opening; The second magnetic member is a second magnetic body, and the second magnetic body is fixedly arranged inside each of the slot holes (11). In the axial direction of the slot holes (11), one end of each of the fixing seats (22) is connected to the auxiliary implantation needle (23), and the other end of each of the fixing seats (22) is magnetically attracted to the second magnetic body inside the corresponding slot hole (11).

7. The flexible microelectrode implantation device according to any one of claims 1-6, characterized in that The implantation control member further includes an adjustment column (52). The first magnetic member is a third magnetic body (53), and the third magnetic body (53) is connected to the adjustment column (52). The adjustment column (52) can adjust the position of the third magnetic body (53) so that the third magnetic body (53) is magnetically attracted to the second magnetic member on each of the fixing seats (22).

8. The flexible microelectrode implantation device according to claim 7, wherein The implantation control member further includes a magnet fixing frame (51). The magnet fixing frame (51) is connected to the end of the adjustment column (52) and can move relative to the adjustment column (52). The third magnetic body (53) is arranged on the magnet fixing frame (51).

9. A flexible microelectrode implantation device, characterized in that, It includes: The flexible microelectrode implantation device according to any one of claims 1-8; A control circuit board (7). One ends of multiple flexible microelectrodes (4) are all connected to the control circuit board (7), and the other ends of the multiple flexible microelectrodes (4) are respectively connected to corresponding auxiliary implantation needles (23); A fastening mechanism for positioning and adjusting the relative position of the control circuit board (7).

10. The flexible microelectrode implantation device according to claim 9, characterized in that, The fastening mechanism includes: A locking frame (61). The fastening mechanism is connected to the base (1) of the flexible microelectrode implantation device through the locking frame (61). The locking frame (61) has two relatively arranged fastening parts; A locking block (62). The locking block (62) and the control circuit board (7) are both arranged between the two fastening parts. The locking block (62) can clamp and fix the control circuit board (7) by adjusting the distance from the adjacent fastening part.

11. The flexible microelectrode implantation device according to claim 10, characterized in that, Threaded holes (613) are correspondingly formed on the locking block (62) and the adjacent fastening part. A pin hole (622) is further formed on the locking block (62). The pin hole (622) is perpendicular to and communicates with the threaded hole (613) on the locking block (62); The fastening mechanism further includes an adapted screw (63) and a pin shaft (65). An annular groove (631) is formed on the adapted screw (63). The adapted screw (63) sequentially passes through the threaded hole (613) on the fastening part and the locking block (62), and the pin shaft (65) passes through the pin hole (622) and is engaged and clamped in the annular groove (631).

12. The flexible microelectrode implantation device according to claim 10, wherein The fastening mechanism includes a fastening body (67). The control circuit board (7) is arranged inside the fastening body (67). The material of the fastening body (67) is an elastic material and can apply a clamping force to the control circuit board (7) under the action of an external force.

13. The flexible microelectrode implantation device according to claim 12, characterized in that, The fastening body (67) and the base (1) are integrally processed and formed by 3D printing.

14. A flexible microelectrode implantation system, characterized in that, It includes: The flexible microelectrode implantation device according to any one of claims 9-13; A positioning device, which is connected to the implantation control member and the fastening mechanism of the flexible microelectrode implantation device, and can perform positioning adjustment on the implantation control member and the fastening mechanism.

15. The flexible microelectrode implantation system according to claim 14, characterized in that The positioning device includes an electromagnet (8), the positioning device is connected to the implantation control member through the electromagnet (8), and the electromagnet (8) drives the implantation control member to move through electromagnetic attraction and disconnection.

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