Codonopsis pilosula, astragalus membranaceus and medlar chewable tablet and preparation method thereof

Abstract

The invention discloses radix codonopsis, radix astragali and fructus lycii chewable tablets and a preparation method thereof, and relates to the technical field of health care products. The chewable tablet comprises the following components in parts by weight: 150-200 parts of codonopsis pilosula, 200-250 parts of astragalus membranaceus, 200-250 parts of glossy privet fruit, 120-170 parts of rhizoma polygonati, 260-360 parts of medlar, 200-250 parts of Chinese date and auxiliary materials. The product is rich in total saponins and crude polysaccharides, the content of the total saponins is 534 mg / 100 g, the content of the crude polysaccharides is 1.37 g / 100 g, and the product has the health-care function of enhancing immunity.

Description

Technical Field

[0001] The invention relates to the technical field of health products, and relates to a codonopsis, astragalus and wolfberry chewable tablet and a preparation method thereof. Background Art

[0002] Immunity refers to the body's ability to resist foreign invasion and maintain the stability of the body's internal environment. Low immunity is one of the main manifestations of sub-health. A survey by WHO shows that a large number of people in the world are in a sub-healthy state. The common symptoms of people in a sub-healthy state include cardiovascular and cerebrovascular diseases, tumors, lung diseases caused by smoking, metabolic diseases, and the high-risk group for sub-health is over 40 years old.

[0003] In fact, sub-health status is reversible. As long as timely adjustments are made, some cardiovascular diseases, tumors, and metabolic diseases can be controlled or improved. my country is one of the areas with a high incidence of sub-health. Chinese scholars have also conducted a lot of research on TCM and immune-related diseases and syndromes, proving that the occurrence of diseases is closely related to immune system disorders. With the progress of society and economy, the improvement of people's living standards, the change of disease patterns, and the pursuit of health and longevity, functional foods that enhance immunity have gradually become popular, and people have begun to shift from focusing on treatment to focusing on prevention.

[0004] The development of functional foods that enhance immunity has generally gone through three stages. The first generation of functional foods only infers the function of the food based on the nutrient composition or fortified nutrients in the food, without scientific verification; the second generation of functional foods refers to foods that have been proven to have the physiological regulation function of enhancing immunity through animal and human experiments; the third generation of functional foods not only need to be proven to have the physiological regulation function of enhancing immunity through animal and human experiments, but also need to know the chemical structure, stable form, content and mechanism of action of the functional factors with this function.

[0005] The present invention is based on the combination of modern medical research, modern nutrition and traditional Chinese medicine theory, and develops a new health food. Summary of the invention

[0006] The purpose of the present invention is to provide a codonopsis, astragalus and wolfberry chewable tablet.

[0007] Another object of the present invention is to provide a method for preparing the codonopsis, astragalus and wolfberry chewable tablets.

[0008] The present invention is achieved through the following technical solutions: A codonopsis, astragalus and wolfberry chewable tablet comprising the following components in parts by weight: Codonopsis pilosula 150-200, Astragalus 200-250, Ligustrum lucidum 200-250, Polygonatum sibiricum 120-170, Lycium barbarum 260-360, Jujube 200-250, and auxiliary materials.

[0009] Furthermore, the codonopsis, astragalus and wolfberry chewable tablets include the following components in parts by weight: Codonopsis pilosula 180, Astragalus membranaceus 225, Ligustrum lucidum 225, Polygonatum 150, Lycium barbarum 300, Jujube 225, and auxiliary materials 620.

[0010] The auxiliary materials include dextrin, xylitol, citric acid and magnesium stearate.

[0011] The auxiliary materials include 450 parts of dextrin, 155 parts of xylitol, 5 parts of citric acid and 10 parts of magnesium stearate.

[0012] Furthermore, the preparation method of the codonopsis, astragalus and wolfberry chewable tablets comprises the following steps: (1) Grind 1 / 2 of Codonopsis pilosula and 1 / 2 of Lycium barbarum through a 100-mesh sieve to obtain a dry paste powder; (2) decocting 1 / 2 of Codonopsis pilosula, 1 / 2 of Lycium barbarum, Astragalus membranaceus, jujube, Ligustrum lucidum, and Polygonatum sibiricum with water, collecting the extract, concentrating under reduced pressure, drying, and crushing to obtain a dry paste; (3) Mix the dry paste fine powder with the dry paste, then mix with other auxiliary materials, add adhesive, and the preparation is completed.

[0013] In the step (2), the reduced pressure concentration is carried out at -0.05Mpa and 60-70°C to a clear paste with a relative density of 1.1-1.3, the clear paste is dried at -0.08Mpa and 60-70°C, and then crushed through a 100-mesh sieve to obtain a dry paste.

[0014] In the step (3), auxiliary materials dextrin and xylitol are added and mixed, and then citric acid dissolved in alcohol is added as a binder, granulated, dried, and then magnesium stearate is added, mixed and tableted to obtain the product.

[0015] The adhesive is obtained by adding citric acid to 90% ethanol and fully dissolving it, wherein 15-20 mL of 90% ethanol is added to every 100 g of dry powder.

[0016] Among the six ingredients in the prescription of the present invention, wolfberry and jujube are medicinal and edible items, and codonopsis, astragalus, glossy privet fruit, and polygonatum are all items that can be used for health food. Among them, astragalus is sweet in taste, enters the spleen and lung meridians, and has the effects of replenishing qi and raising yang, benefiting the body's defense and strengthening the exterior, supporting toxins and promoting muscle growth, and promoting diuresis and reducing swelling; codonopsis is sweet and flat in nature, and has the effects of replenishing the middle and replenishing qi, strengthening the spleen and stomach, promoting the production of body fluids and quenching thirst, and the combination of the two has a significant effect of enhancing immunity; wolfberry is sweet in taste, enters the liver and kidney meridians, can nourish the liver and kidney, benefit the essence and improve eyesight, moisten the lungs and stop coughing, and delay aging; jujube is sweet, enters the spleen and stomach meridians, and has the effects of replenishing the middle and replenishing qi, nourishing blood and calming the nerves; glossy privet fruit is sweet, slightly bitter, and cool, enters the liver and kidney meridians, and has the effects of nourishing the liver and kidney, improving eyesight and darkening hair. In summary, the main drugs Astragalus and Codonopsis of the present invention mainly contain polysaccharides and saponins, the auxiliary drug Polygonatum sibiricum and the adjuvant drugs Fructus Ligustri Lucidi, Fructus Lycii and Jujube are all mainly polysaccharides. Modern pharmacological studies have shown that both saponins and polysaccharides have clear effects of enhancing immunity and are the main effective ingredients of this product. The spectrophotometric method is used to determine these two types of effective ingredients in the product with ginsenoside Re and glucose as standard products, respectively, wherein the total saponins (calculated as ginsenosides) mg / 100g≧400mg, and the crude polysaccharides (calculated as glucose) g / 100g≧1.0g.

[0017] The product of the invention is rich in total saponin and crude polysaccharide, wherein the total saponin content is 534 mg / 100 g, and the crude polysaccharide content is 1.37 g / 100 g, and has a strong health care function of enhancing immunity. DETAILED DESCRIPTION

[0018] Example 1 A method for preparing a codonopsis, astragalus and wolfberry chewable tablet, comprising the following steps: 1. Pretreatment: After the Codonopsis pilosula, Astragalus membranaceus, Ligustrum lucidum, Polygonatum sibiricum, Lycium barbarum, and jujube are inspected and qualified, they are added according to the following prescription amount; among them, 1 / 2 Codonopsis pilosula and 1 / 2 Lycium barbarum are cleaned and crushed through a 100-mesh sieve for standby use; 2. Ingredients (prescription quantity for 1000 tablets): 180g Codonopsis pilosula, 225g Astragalus, 225g Ligustrum lucidum, 150g Polygonatum, 300g Lycium barbarum, 225g Jujube (about 580g powder); Auxiliary materials: dextrin 450g, xylitol 155g, citric acid 5g, magnesium stearate 10g; A total of 1000 tablets (1.2 g / tablet) were prepared; 3. Extraction: (1) According to the formula, 1 / 2 Codonopsis pilosula, 1 / 2 Lycium barbarum, Astragalus membranaceus, Jujube, Ligustrum lucidum, and Polygonatum sibiricum were taken and boiled in pure drinking water for 3 times, each time for 1.0 hour, with the amount of water added being 8 times, and filtered through a 120-mesh sieve, and the filtrate was set aside; (2) According to the recipe, 1 / 2 of the processed wolfberry and 1 / 2 of the codonopsis pilosula were crushed, passed through a 100-mesh sieve, and set aside. The powder yield was 97.4%; 4. Concentration: The filtrate extracted in step 3 (1) was concentrated under reduced pressure (-0.05 MPa, 70°C) to a clear paste with a relative density of about 1.20 (70°C), and dried under reduced pressure (-0.08 MPa, 60-70°C) to obtain 269 g of dry paste. The yield of the extracted part was about 32.6%; 5. Molding (1) Take the above dry paste, crush it, pass it through a 100-mesh sieve, and obtain about 260g of fine powder for later use; (2) Grind the various excipients in the formula, wherein magnesium stearate is sieved through a 60-mesh sieve, and the remaining dextrin and xylitol are sieved through a 100-mesh sieve for later use; (3) Mix the dry paste powder with the powder from step 3 (2), and then mix with the auxiliary materials dextrin and xylitol for 20 minutes until the color is uniform to obtain a mixed powder for later use; (4) Take citric acid and add about 200 ml of alcohol containing 90% ethanol to fully dissolve it, and use it as a binder for granulation. Add it to step 5 (3) to make a soft material, granulate it, pass it through a 14-mesh sieve, and then dry it at 65°C. The moisture content is <3%; (5) Add magnesium stearate to the dry granules and mix well to obtain the total mixed granules. Adjust the pressure, speed and tablet weight of the tablet press so that the tablet weight difference reaches 1.2 g / tablet ± 5%.

[0019] The total saponin content (calculated as ginsenoside) in the finished product was determined to be 534 mg / 100 g, and the crude polysaccharide content (calculated as glucose) was 1.37 g / 100 g.

[0020] The sensory test results of the finished product are shown in Table 1. Table 1

[0021] The physical and chemical indicators of the finished product were measured, and the results are shown in Table 2. Table 2

[0022] Example 2 A method for preparing a codonopsis, astragalus and wolfberry chewable tablet, comprising the following steps: 1. Pretreatment: After Codonopsis pilosula, Astragalus membranaceus, Ligustrum lucidum, Polygonatum sibiricum, Lycium barbarum, and jujube have passed the inspection, add the following prescription amount for processing; 2. Ingredients (prescription quantity for 1000 tablets): 180g Codonopsis pilosula, 225g Astragalus, 225g Ligustrum lucidum, 150g Polygonatum, 300g Lycium barbarum, 225g Jujube (about 580g powder); Auxiliary materials: dextrin 450g, xylitol 155g, citric acid 5g, magnesium stearate 10g; A total of 1000 tablets (1.2 g / tablet) were prepared; 3. Extraction: Add the accurately weighed components to drinking pure water and boil for extraction 3 times, 1.0 hour each time, with 8 times the amount of water added, filter through a 120-mesh sieve, and set aside the filtrate; 4. Concentration: The filtrate extracted in step 3 was concentrated under reduced pressure (-0.05Mpa, 70°C) to a clear paste with a relative density of about 1.20 (70°C), and dried under reduced pressure (-0.08Mpa, 60-70°C) to obtain 269g of dry paste, with a paste yield of about 32.6%; 5. Molding (1) Take the above dry paste, crush it, pass it through a 100-mesh sieve, and obtain about 260g of fine powder for later use; (2) Grind the various excipients in the formula, wherein magnesium stearate is sieved through a 60-mesh sieve, and the remaining dextrin and xylitol are sieved through a 100-mesh sieve for later use; (3) Mix the dry paste powder with the auxiliary materials dextrin and xylitol for 20 minutes until the color is uniform to obtain a mixed powder, which is set aside; (4) Take citric acid and add about 200 ml of alcohol containing 90% ethanol to fully dissolve it, and use it as a binder for granulation. Add it to step 5 (3) to make a soft material, granulate it, pass it through a 14-mesh sieve, and then dry it at 65°C. The moisture content is <3%; (5) Add magnesium stearate to the dry granules and mix well to obtain the total mixed granules. Adjust the pressure, speed and tablet weight of the tablet press so that the tablet weight difference reaches 1.2 g / tablet ± 5%.

[0023] The total saponin content (calculated as ginsenoside) in the finished product was determined to be 487 mg / 100 g, and the crude polysaccharide content (calculated as glucose) was 1.28 g / 100 g. In addition, the chewable tablets were cracked and the surface was not smooth enough. It can be seen that the processing technology of Codonopsis pilosula and Lycium barbarum has a certain impact on the appearance quality and nutritional content of the finished products.

[0024] Example 3 Preparation method of codonopsis, astragalus and wolfberry chewable tablets 1. Pretreatment: After the Codonopsis pilosula, Astragalus membranaceus, Polygonatum sibiricum, Lycium barbarum, and jujube are inspected and qualified, they are added according to the following prescription amount; among them, 1 / 2 Codonopsis pilosula and 1 / 2 Lycium barbarum are cleaned and crushed through a 100-mesh sieve for standby use; 2. Ingredients (prescription quantity for 1000 tablets): 180g Codonopsis pilosula, 225g Astragalus, 150g Polygonatum, 300g Lycium barbarum, 225g Jujube (about 580g powder); Auxiliary materials: dextrin 450g, xylitol 155g, citric acid 5g, magnesium stearate 10g; A total of 1000 tablets (1.2 g / tablet) were prepared; 3. Extraction: (1) According to the formula, 1 / 2 Codonopsis pilosula, 1 / 2 Lycium barbarum, Astragalus, Jujube, and Polygonatum sibiricum were taken and boiled with drinking purified water for 3 times, each time for 1.0 hour, with the amount of water added being 8 times, and filtered through a 120-mesh sieve, and the filtrate was set aside; (2) According to the recipe, 1 / 2 of the processed wolfberry and 1 / 2 of the codonopsis pilosula were crushed, passed through a 100-mesh sieve, and set aside. The powder yield was 97.4%; 4. Concentration: The filtrate extracted in step 3 (1) was concentrated under reduced pressure (-0.05 MPa, 70°C) to a clear paste with a relative density of about 1.20 (70°C), and dried under reduced pressure (-0.08 MPa, 60-70°C) to obtain 269 g of dry paste. The yield of the extracted part was about 32.6%; 5. Molding (1) Take the above dry paste, crush it, pass it through a 100-mesh sieve, and obtain about 260g of fine powder for later use; (2) Grind the various excipients in the formula, wherein magnesium stearate is sieved through a 60-mesh sieve, and the remaining dextrin and xylitol are sieved through a 100-mesh sieve for later use; (3) Mix the dry paste powder with the powder from step 3 (2), and then mix with the auxiliary materials dextrin and xylitol for 20 minutes until the color is uniform to obtain a mixed powder for later use; (4) Take citric acid and add about 200 ml of alcohol containing 90% ethanol to fully dissolve it, and use it as a binder for granulation. Add it to step 5 (3) to make a soft material, granulate it, pass it through a 14-mesh sieve, and then dry it at 65°C. The moisture content is <3%; (5) Add magnesium stearate to the dry granules and mix well to obtain the total mixed granules. Adjust the pressure, speed and tablet weight of the tablet press so that the tablet weight difference reaches 1.2 g / tablet ± 5%.

[0025] The total saponin content (calculated as ginsenoside) in the finished product was determined to be 342 mg / 100 g, and the crude polysaccharide content (calculated as glucose) was 0.97 g / 100 g.

[0026] Example 4 Preparation method of codonopsis, astragalus and wolfberry chewable tablets 1. Pretreatment: After Codonopsis pilosula, Astragalus membranaceus, Ligustrum lucidum fruit, Lycium barbarum fruit and jujube are inspected and qualified, they are added according to the following prescription amount; among them, 1 / 2 Codonopsis pilosula and 1 / 2 Lycium barbarum fruit are cleaned and crushed through a 100-mesh sieve for standby use; 2. Raw materials: 150g Codonopsis pilosula, 250g Astragalus membranaceus, 200g Ligustrum lucidum, 360g Lycium barbarum, 250g Jujube; Auxiliary materials: dextrin 450g, xylitol 155g, citric acid 5g, magnesium stearate 10g; 3. Extraction: (1) According to the formula, 1 / 2 Codonopsis pilosula, 1 / 2 Lycium barbarum, Astragalus, Jujube, and Ligustrum lucidum were decocted and extracted 3 times with drinking water, each time for 1.2 hours, with the amount of water added being 8 times, and filtered through a 120-mesh sieve, and the filtrate was set aside; (2) According to the recipe, 1 / 2 of the processed wolfberry and 1 / 2 of the codonopsis pilosula were crushed, passed through a 100-mesh sieve, and set aside. The powder yield was 97.2%; 4. Concentration: The filtrate extracted in step 3 (1) was concentrated under reduced pressure (-0.05 MPa, 70°C) to a clear paste with a relative density of about 1.10 (70°C), and dried under reduced pressure (-0.08 MPa, 60-70°C) to obtain 269 g of dry paste. The yield of the extracted part was about 32.7%; 5. Molding (1) Take the above dry paste, crush it, pass it through a 100-mesh sieve, and set aside; (2) Grind the various excipients in the formula, wherein magnesium stearate is sieved through a 60-mesh sieve, and the remaining dextrin and xylitol are sieved through a 100-mesh sieve for later use; (3) Mix the dry paste powder with the powder from step 3 (2), and then mix with the auxiliary materials dextrin and xylitol for 20 minutes until the color is uniform to obtain a mixed powder for later use; (4) Take citric acid and add about 200 ml of alcohol containing 90% ethanol to fully dissolve it, and use it as a binder for granulation. Add it to step 5 (3) to make a soft material, granulate it, pass it through a 14-mesh sieve, and then dry it at 65°C. The moisture content is <3%; (5) Add magnesium stearate to the dry granules and mix well to obtain the total mixed granules. Adjust the pressure, speed and tablet weight of the tablet press so that the tablet weight difference reaches 1.2 g / tablet ± 5%.

[0027] The total saponin content (calculated as ginsenoside) in the finished product was determined to be 368 mg / 100 g, and the crude polysaccharide content (calculated as glucose) was 0.98 g / 100 g.

[0028] Example 5 Preparation method of codonopsis, astragalus and wolfberry chewable tablets 1. Pretreatment: After the Codonopsis pilosula, Astragalus membranaceus, Ligustrum lucidum, Polygonatum sibiricum, Lycium barbarum, and jujube are inspected and qualified, they are added according to the following prescription amount; among them, 1 / 2 Codonopsis pilosula and 1 / 2 Lycium barbarum are cleaned and crushed through a 100-mesh sieve for standby use; 2. Raw materials: Codonopsis pilosula 200g, Astragalus 200g, Ligustrum lucidum 250g, Polygonatum sibiricum 170g, Lycium barbarum 260g, Jujube 200g; Auxiliary materials: dextrin 450g, xylitol 155g, citric acid 5g, magnesium stearate 10g; 3. Extraction: (1) According to the formula, 1 / 2 Codonopsis pilosula, 1 / 2 Lycium barbarum, Astragalus, Jujube, Ligustrum lucidum, and Polygonatum sibiricum were taken and boiled in pure drinking water for 3 times, each time for 1.2 hours, with the amount of water added being 8 times, and filtered through a 120-mesh sieve, and the filtrate was set aside; (2) According to the recipe, 1 / 2 of the processed wolfberry and 1 / 2 of the codonopsis pilosula were crushed, passed through a 100-mesh sieve, and set aside. The powder yield was 97.2%; 4. Concentration: The filtrate extracted in step 3 (1) was concentrated under reduced pressure (-0.05 MPa, 70°C) to a clear paste with a relative density of about 1.10 (70°C), and dried under reduced pressure (-0.08 MPa, 60-70°C) to obtain 269 g of dry paste. The yield of the extracted part was about 32.7%; 5. Molding (1) Take the above dry paste, crush it, pass it through a 100-mesh sieve, and set aside; (2) Grind the various excipients in the formula, wherein magnesium stearate is sieved through a 60-mesh sieve, and the remaining dextrin and xylitol are sieved through a 100-mesh sieve for later use; (3) Mix the dry paste powder with the powder from step 3 (2), and then mix with the auxiliary materials dextrin and xylitol for 20 minutes until the color is uniform to obtain a mixed powder for later use; (4) Take citric acid and add about 200 ml of alcohol containing 90% ethanol to fully dissolve it, and use it as a binder for granulation. Add it to step 5 (3) to make a soft material, granulate it, pass it through a 14-mesh sieve, and then dry it at 65°C. The moisture content is <3%; (5) Add magnesium stearate to the dry granules and mix well to obtain the total mixed granules. Adjust the pressure, speed and tablet weight of the tablet press so that the tablet weight difference reaches 1.2 g / tablet ± 5%.

[0029] The total saponin content (calculated as ginsenoside) in the finished product was determined to be 522 mg / 100 g, and the crude polysaccharide content (calculated as glucose) was 1.34 g / 100 g. Example

[0030] The finished products prepared in Examples 1-5 were expanded by 10, 20, and 30 according to the recommended daily intake of 0.18 g / kg BW for the finished product population, setting low, medium, and high dosage groups, namely 1.8 g / kg BW, 3.6 g / kg BW, and 5.4 g / kg BW, and a negative control group was set up separately. SPF-grade Kunming mice were used, and continuous gavage was given, and relevant indicators were detected after 30 days. The experimental results were judged as significant differences with P<0.05. The comparison of each dosage group with the negative control group showed that: 1. The high-dose group can significantly enhance the proliferation ability of mouse spleen lymphocytes induced by ConA, and the effects of the finished products of Examples 1 and 5 are significantly higher than those of Examples 2, 3, and 4; 2. The medium and high dose groups can significantly enhance the DTH response of mice to DNFB, and the effects of the finished products of Examples 1 and 5 are significantly higher than those of Examples 2, 3, and 4; 3. The high-dose group can significantly improve the carbon clearance phagocytosis index of mice, and the effects of the finished products of Examples 1 and 5 are significantly higher than those of Examples 2, 3, and 4; 4. The high-dose group can significantly increase the phagocytic percentage and phagocytic index of mouse peritoneal macrophages, and the effects of the finished products of Examples 1 and 5 are significantly higher than those of Examples 2, 3, and 4.

[0031] According to the evaluation procedure for the function of enhancing immunity, the test sample is positive for mouse cellular immune function, negative for body night immune function, positive for monocyte-macrophage function, and negative for NK cell activity, that is, the product of the present invention has the function of enhancing immunity, and the finished products prepared in Examples 1 and 5 have significantly higher immunity-enhancing function than Examples 2, 3, and 4.

[0032] It can be seen that when the component of Ligustrum lucidum or Polygonatum sibiricum is lacking, the contents of total saponins and polysaccharides in the finished product are sharply reduced, and Ligustrum lucidum polysaccharide has a great effect on the body's immunity, it has an enhancing effect on non-specific cellular immunity, and has an enhancing effect on the cellular immunity of the body in the immunosuppressive state. The oleanolic acid in Ligustrum lucidum has the function of promoting lymphocyte proliferation and animal macrophage phagocytosis. When Example 3 lacks Ligustrum lucidum, the total saponin and polysaccharide contents of the finished product are significantly reduced, and its health care effect and the improvement of the body's immune ability are not significant; the ministerial drug Polygonatum sibiricum contains steroidal saponins and Polygonatum sibiricum polysaccharides, which have a strong tonic effect on the spleen and lungs, and can significantly enhance the immunity of sub-healthy people. When Example 4 lacks Polygonatum sibiricum, the contents of saponins and polysaccharides are significantly reduced; and in Examples 1 and 5, Codonopsis pilosula, Astragalus membranaceus, Ligustrum lucidum, and Polygonatum sibiricum work synergistically to significantly increase the contents of polysaccharides and saponins, and have a significant effect on improving immunity.

Claims

1. A codonopsis, astragalus and wolfberry chewable tablet, characterized in that: The invention comprises the following components in parts by weight: 150-200 parts of codonopsis pilosula, 200-250 parts of astragalus, 200-250 parts of glossy privet fruit, 120-170 parts of polygonatum, 260-360 parts of wolfberry, 200-250 parts of jujube and auxiliary materials.

2. The codonopsis, astragalus and wolfberry chewable tablet according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 180 parts of Codonopsis pilosula, 225 parts of Astragalus membranaceus, 225 parts of Ligustrum lucidum fruit, 150 parts of Polygonatum sibiricum, 300 parts of Lycium barbarum fruit, 225 parts of jujube, and 620 parts of auxiliary materials.

3. A codonopsis, astragalus and wolfberry chewable tablet according to claim 1 or 2, characterized in that: The auxiliary materials include dextrin, xylitol, citric acid and magnesium stearate.

4. The codonopsis, astragalus and wolfberry chewable tablet according to claim 3, characterized in that: The auxiliary materials include 450 parts of dextrin, 155 parts of xylitol, 5 parts of citric acid and 10 parts of magnesium stearate.

5. The method for preparing the codonopsis, astragalus and wolfberry chewable tablets according to any one of claims 1 to 4, characterized in that: The steps are: (1) Grind 1 / 2 of Codonopsis pilosula and 1 / 2 of Lycium barbarum through a 100-mesh sieve to obtain a dry paste powder; (2) decocting 1 / 2 of Codonopsis pilosula, 1 / 2 of Lycium barbarum, Astragalus membranaceus, jujube, Ligustrum lucidum, and Polygonatum sibiricum with water, collecting the extract, concentrating under reduced pressure, drying, and crushing to obtain a dry paste; (3) Mix the dry paste fine powder with the dry paste, then mix with other auxiliary materials, add adhesive, and the preparation is completed.

6. The method for preparing the codonopsis, astragalus and wolfberry chewable tablets according to claim 5, characterized in that: In the step (2), the reduced pressure concentration is carried out at -0.05Mpa and 60-70°C to a clear paste with a relative density of 1.1-1.3, the clear paste is dried at -0.08Mpa and 60-70°C, and then crushed through a 100-mesh sieve to obtain a dry paste.

7. The method for preparing the codonopsis, astragalus and wolfberry chewable tablets according to claim 5, characterized in that: In the step (3), auxiliary materials dextrin and xylitol are added and mixed, and then citric acid dissolved in alcohol is added as a binder, granulated, dried, and then magnesium stearate is added, mixed and tableted to obtain the product.

8. The method for preparing the codonopsis, astragalus and wolfberry chewable tablets according to claim 5, characterized in that: The adhesive is obtained by adding citric acid to 90% ethanol and fully dissolving it, wherein 15-20 mL of 90% ethanol is added to every 100 g of dry powder.

Images