Preparation method of red ginseng paste with blood vessel softening effect

Abstract

The invention discloses a preparation method of red ginseng paste with a blood vessel softening effect, which comprises the following steps: step S1, firstly, mixing and grinding XinKaihe red ginseng, ligusticum wallichii and radix aconiti into powder according to a proportion to obtain a powder raw material; s2, adding 8-15 times of ethanol aqueous solution into the powder raw material for extraction, combining the extracting solutions, and filtering; step S3, weighing the corresponding amount of rock sugar according to the formula proportion, adding 30-50 times of distilled water, heating for dissolving, adding the dissolved rock sugar into the extracting solution in the step S2, and continuously stirring until the solution is thick; and S4, weighing xylooligosaccharide, stachyose and probiotic powder according to a ratio, adding the weighed xylooligosaccharide, stachyose and probiotic powder into the oral thick paste in the step S3, uniformly stirring, collecting the paste, sterilizing, and packaging to obtain the red ginseng paste with the blood vessel softening effect. Ginsenoside in the Xinkaihe red ginseng can be combined with aconitine in the radix aconiti to improve the activity of cardiac muscle cells, synergistic interaction is achieved in improving the activity of cardiovascular cells, and blood vessels can be effectively softened.

Description

Technical Field

[0001] The invention relates to the technical field of red ginseng paste, and in particular to a method for preparing red ginseng paste with a blood vessel softening effect. Background Art

[0002] With the improvement of modern living standards, people are eating more greasy food, and work pressure has led to an increasing number of smokers, resulting in high blood pressure and high blood lipids. High blood pressure, high blood lipids, and smoking are the three most important risk factors for arteriosclerosis. Other factors such as obesity, diabetes, lack of exercise, stress, old age, family history, and bad temper can also cause arteriosclerosis. Arteriosclerosis may lead to myocardial infarction and stroke, and in severe cases, death, so we should pay enough attention to arteriosclerosis.

[0003] Ginseng can regulate the balance of the central nervous system's excitation and inhibition processes, improve brain oxygen uptake, improve anti-fatigue effects, improve the body's adaptability, have a good effect on the cardiovascular system, increase the enzyme activity of liver metabolism of various substances, enhance the body's tolerance to various chemicals, strengthen the body's resistance to harmful factors, etc. The high-frequency work rhythm has brought more and more people to sub-health, but the development of ginseng products with the effect of softening blood vessels is relatively lacking and cannot meet the needs of the health care market. For this reason, the development of red ginseng paste has a unique market positioning and urgent needs. Summary of the invention

[0004] The present invention provides a method for preparing red ginseng paste with blood vessel softening effect, so as to solve the problems raised in the above background technology.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions: A method for preparing red ginseng paste having a blood vessel softening effect comprises the following steps: Step S1, firstly, Xinkaihe red ginseng, Chuanxiong and Chuanwu are mixed and ground into powder according to a certain proportion to obtain a powder raw material; Step S2, adding 8-15 times the amount of ethanol aqueous solution to the powder raw material for extraction, and combining the extracts for filtration; Step S3, weighing a corresponding amount of rock sugar according to the formula ratio, adding 30-50 times of distilled water, heating to dissolve, adding the dissolved rock sugar to the extract of step S2, and continuing to stir until it becomes viscous; Step S4, weighing xylooligosaccharides, stachyose, and probiotic powder according to proportion, adding them to the paste of step S3, stirring evenly to obtain the paste, and packaging after sterilization to obtain the red ginseng paste with the effect of softening blood vessels.

[0006] As a further improvement of the technical solution: the composition and weight percentage of the red ginseng paste are: 35-40% Xinkaihe red ginseng, 10-30% Chuanxiong, 10-30% Chuanwu, 15% crystal sugar, 5% xylo-oligosaccharide, 5% stachyose, and 5% probiotic powder.

[0007] As a further improvement of the technical solution: the composition and weight percentage of the red ginseng paste are: 35% Xinkaihe red ginseng, 20% Chuanxiong, 15% Chuanwu, 15% crystal sugar, 5% xylo-oligosaccharide, 5% stachyose, and 5% probiotic powder.

[0008] As a further improvement of the technical solution: the composition and weight percentage of the red ginseng paste are: 37% Xinkaihe red ginseng, 19% Chuanxiong, 14% Chuanwu, 15% crystal sugar, 5% xylo-oligosaccharide, 5% stachyose, and 5% probiotic powder.

[0009] As a further improvement of the technical solution: the composition and weight percentage of the red ginseng paste are: 38% Xinkaihe red ginseng, 18% Chuanxiong, 14% Chuanwu, 15% crystal sugar, 5% xylo-oligosaccharide, 5% stachyose, and 5% probiotic powder.

[0010] As a further improvement of the technical solution: the composition and weight percentage of the red ginseng paste are: 40% Xinkaihe red ginseng, 16% Chuanxiong, 14% Chuanwu, 15% crystal sugar, 5% xylo-oligosaccharide, 5% stachyose, and 5% probiotic powder.

[0011] As a further improvement of the technical solution: in step S1, the Xinkaihe red ginseng, Chuanxiong and Chuanwu are crushed to 100-150 meshes respectively.

[0012] As a further improvement of the technical solution: in step S2, the ethanol aqueous solution is ethanol with a concentration of 70-75%.

[0013] As a further improvement of the present technical solution: in step S4, the sterilization temperature is controlled at 80-95°C, and the sterilization time is 30 minutes.

[0014] Compared with the prior art, the present invention has the following beneficial effects: The ginsenosides in the Xinkaihe red ginseng of the present invention can be combined with aconitine in Chuanwu to improve the vitality of myocardial cells, synergistically enhance the effect in improving the activity of cardiovascular cells, and can effectively soften blood vessels. The red ginseng paste with the effect of softening blood vessels is safe and effective and worthy of promotion.

[0015] The above description is only an overview of the technical solution of the present invention. In order to more clearly understand the technical means of the present invention and implement it according to the contents of the specification, the following is a detailed description of the preferred embodiments of the present invention in conjunction with the accompanying drawings. The specific implementation of the present invention is given in detail by the following embodiments and their accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The drawings described herein are used to provide a further understanding of the present invention and constitute a part of this application. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the drawings: Figure 1 The present invention is a schematic diagram of the steps of preparing a red ginseng paste having a blood vessel softening effect. DETAILED DESCRIPTION

[0017] The principles and features of the present invention are described below in conjunction with the accompanying drawings. The examples given are only used to explain the present invention and are not used to limit the scope of the present invention. The present invention is described in more detail by way of example with reference to the accompanying drawings in the following paragraphs. It should be noted that the accompanying drawings are all in a very simplified form and are not in precise proportions, and are only used to facilitate and clearly assist in explaining the purpose of the embodiments of the present invention.

[0018] Embodiment 1 A method for preparing red ginseng paste having a blood vessel softening effect comprises the following steps: Step S1, firstly, Xinkaihe red ginseng, Chuanxiong and Chuanwu are mixed according to a proportion and ground into powder, and crushed into 100-150 meshes to obtain a powder raw material; Step S2, adding 8-15 times the amount of 70-75% ethanol to the powder raw material for extraction, and combining the extracts for filtration; Step S3, weighing a corresponding amount of rock sugar according to the formula ratio, adding 30-50 times of distilled water, heating to dissolve, adding the dissolved rock sugar to the extract of step S2, and continuing to stir until it becomes viscous; Step S4, weighing xylooligosaccharides, stachyose, and probiotic powder in proportion and adding them to the paste of step S3, stirring evenly to collect the paste, and packaging after sterilization, the sterilization temperature is controlled at 80-95° C., and the sterilization time is 30 minutes to obtain a red ginseng paste with a blood vessel softening effect, the composition and weight percentage of the red ginseng paste are: 35% of Xinkaihe red ginseng, 20% of Chuanxiong, 15% of Chuanwu, 15% of crystal sugar, 5% of xylooligosaccharides, 5% of stachyose, and 5% of probiotic powder.

[0019] Embodiment 2 A method for preparing red ginseng paste having a blood vessel softening effect comprises the following steps: Step S1, firstly, Xinkaihe red ginseng, Chuanxiong and Chuanwu are mixed according to a proportion and ground into powder, and crushed into 100-150 meshes to obtain a powder raw material; Step S2, adding 8-15 times the amount of 70-75% ethanol to the powder raw material for extraction, and combining the extracts for filtration; Step S3, weighing a corresponding amount of rock sugar according to the formula ratio, adding 30-50 times of distilled water, heating to dissolve, adding the dissolved rock sugar to the extract of step S2, and continuing to stir until it becomes viscous; Step S4, weighing xylooligosaccharides, stachyose, and probiotic powder in proportion and adding them to the paste of step S3, stirring evenly to collect the paste, and packaging after sterilization, the sterilization temperature is controlled at 80-95° C., and the sterilization time is 30 minutes to obtain a red ginseng paste with a blood vessel softening effect, the composition and weight percentage of the red ginseng paste are: 35% of Xinkaihe red ginseng, 20% of Chuanxiong, 15% of Chuanwu, 15% of crystal sugar, 5% of xylooligosaccharides, 5% of stachyose, and 5% of probiotic powder.

[0020] Embodiment 3 A method for preparing red ginseng paste having a blood vessel softening effect comprises the following steps: Step S1, firstly, Xinkaihe red ginseng, Chuanxiong and Chuanwu are mixed according to a proportion and ground into powder, and crushed into 100-150 meshes to obtain a powder raw material; Step S2, adding 8-15 times the amount of 70-75% ethanol to the powder raw material for extraction, and combining the extracts for filtration; Step S3, weighing a corresponding amount of rock sugar according to the formula ratio, adding 30-50 times of distilled water, heating to dissolve, adding the dissolved rock sugar to the extract of step S2, and continuing to stir until it becomes viscous; Step S4, weighing xylooligosaccharides, stachyose, and probiotic powder in proportion and adding them to the paste of step S3, stirring evenly to collect the paste, and packaging after sterilization, the sterilization temperature is controlled at 80-95° C., and the sterilization time is 30 minutes to obtain a red ginseng paste with a blood vessel softening effect, the composition and weight percentage of the red ginseng paste are: 35% of Xinkaihe red ginseng, 20% of Chuanxiong, 15% of Chuanwu, 15% of crystal sugar, 5% of xylooligosaccharides, 5% of stachyose, and 5% of probiotic powder.

[0021] Embodiment 4 A method for preparing red ginseng paste having a blood vessel softening effect comprises the following steps: Step S1, firstly, Xinkaihe red ginseng, Chuanxiong and Chuanwu are mixed according to a proportion and ground into powder, and crushed into 100-150 meshes to obtain a powder raw material; Step S2, adding 8-15 times the amount of 70-75% ethanol to the powder raw material for extraction, and combining the extracts for filtration; Step S3, weighing a corresponding amount of rock sugar according to the formula ratio, adding 30-50 times of distilled water, heating to dissolve, adding the dissolved rock sugar to the extract of step S2, and continuing to stir until it becomes viscous; Step S4, weighing xylooligosaccharides, stachyose, and probiotic powder in proportion and adding them to the paste of step S3, stirring evenly to collect the paste, and packaging after sterilization, the sterilization temperature is controlled at 80-95° C., and the sterilization time is 30 minutes to obtain a red ginseng paste with a blood vessel softening effect, the composition and weight percentage of the red ginseng paste are: 35% of Xinkaihe red ginseng, 20% of Chuanxiong, 15% of Chuanwu, 15% of crystal sugar, 5% of xylooligosaccharides, 5% of stachyose, and 5% of probiotic powder.

[0022] Tests of Examples 1, 2 and 3: 90 subjects were selected, aged 45-55 years old, with an average age of 50.5 years old. The clinical manifestations were cerebral artery insufficiency, primary hypertension; deep brain white matter ischemia, limb vascular ultrasound showed insufficient blood perfusion of the distal artery of the left lower limb, increased peripheral arterial stiffness; neck ultrasound showed bilateral bulbar intimal thickening with plaque formation; bilateral anterior cerebral artery flow velocity asymmetry. The subjects were randomly divided into three groups, and the three groups corresponded to the use of the red ginseng paste of Examples 1, 2, and 3, three times a day, 10 mg each time, for 2 consecutive months, and then three times a day, 5 mg each time, for 4 consecutive months. After 6 months, the subjects' conditions were tested, as shown in Table 1 below. The following data are the average values ​​of each group Whole blood viscosity ET in plasma (pg / ml) Embodiment 1 17.7 161.3 Embodiment 2 18.3 162.4 Embodiment 3 17.4 161.9 According to Table 1, the red ginseng creams of Examples 1, 2 and 3 of the present invention can reduce the whole blood viscosity and the ET content in plasma. It can be seen that the medicine of the present invention can soften blood vessels and normalize the blood circulation of the body. The test results of the subjects were investigated, indicating that the blood pressure and blood lipids of the subjects were significantly reduced, and headaches and dizziness rarely occurred, and the symptoms almost did not recur.

[0023] In summary, the medicament for vascular softening in the embodiment of the present invention can effectively treat cerebral infarction, cardiovascular and cerebrovascular insufficiency, hyperlipidemia and the like by dilating blood vessels and softening blood clots on the blood vessel walls, thereby normalizing blood circulation, and can achieve the purpose of treating both the symptoms and the root causes, with small side effects and low economic pressure. In the embodiment of the present invention, the ginsenosides in Xinkaihe red ginseng can be combined with aconitine in Chuanwu to improve the viability of myocardial cells, synergistically enhance the effect in improving the activity of cardiovascular cells, and can effectively soften blood vessels.

[0024] In the preparation method of the drug for vascular softening, different extraction methods are selected for different medicinal materials to extract, which can significantly improve the utilization rate of the effective ingredients of the medicinal materials and thus enhance the efficacy of the drug.

[0025] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Any ordinary technician in the industry can smoothly implement the present invention as shown in the drawings and described above. However, any equivalent changes, modifications and evolutions made by technicians familiar with the profession without departing from the scope of the technical solution of the present invention using the technical content disclosed above are all equivalent embodiments of the present invention. At the same time, any equivalent changes, modifications and evolutions made to the above embodiments based on the essential technology of the present invention are still within the protection scope of the technical solution of the present invention.

Claims

1. A method for preparing red ginseng paste having a blood vessel softening effect, characterized in that: The method comprises the following steps: Step S1, firstly, Xinkaihe red ginseng, Chuanxiong and Chuanwu are mixed and ground into powder according to a certain proportion to obtain a powder raw material; Step S2, adding 8-15 times the amount of ethanol aqueous solution to the powder raw material for extraction, and combining the extracts for filtration; Step S3, weighing a corresponding amount of rock sugar according to the formula ratio, adding 30-50 times of distilled water, heating to dissolve, adding the dissolved rock sugar to the extract of step S2, and continuing to stir until it becomes viscous; Step S4, weighing xylooligosaccharides, stachyose, and probiotic powder according to proportion, adding them to the paste of step S3, stirring evenly to obtain the paste, and packaging after sterilization to obtain the red ginseng paste with the effect of softening blood vessels.

2. The method for preparing a red ginseng paste having a blood vessel softening effect according to claim 1, characterized in that: The composition and weight percentage of the red ginseng paste are: 35-40% of Xinkaihe red ginseng, 10-30% of Chuanxiong, 10-30% of Chuanwu, 15% of crystal sugar, 5% of xylo-oligosaccharide, 5% of stachyose and 5% of probiotic powder.

3. The method for preparing a red ginseng paste having a blood vessel softening effect according to claim 1, characterized in that: The composition and weight percentage of the red ginseng paste are: 35% of Xinkaihe red ginseng, 20% of Chuanxiong, 15% of Chuanwu, 15% of crystal sugar, 5% of xylo-oligosaccharide, 5% of stachyose, and 5% of probiotic powder.

4. The method for preparing a red ginseng paste having a blood vessel softening effect according to claim 1, characterized in that: The composition and weight percentage of the red ginseng paste are: 37% of Xinkaihe red ginseng, 19% of Chuanxiong, 14% of Chuanwu, 15% of crystal sugar, 5% of xylo-oligosaccharide, 5% of stachyose, and 5% of probiotic powder.

5. The method for preparing red ginseng paste having a blood vessel softening effect according to claim 1, characterized in that: The composition and weight percentage of the red ginseng paste are: 38% of Xinkaihe red ginseng, 18% of Chuanxiong, 14% of Chuanwu, 15% of crystal sugar, 5% of xylo-oligosaccharide, 5% of stachyose, and 5% of probiotic powder.

6. The method for preparing a red ginseng paste having a blood vessel softening effect according to claim 1, characterized in that: The composition and weight percentage of the red ginseng paste are: 40% Xinkaihe red ginseng, 16% Chuanxiong, 14% Chuanwu, 15% crystal sugar, 5% xylo-oligosaccharide, 5% stachyose, and 5% probiotic powder.

7. The method for preparing red ginseng paste having a blood vessel softening effect according to claim 1, characterized in that: In the step S1, the Xinkaihe red ginseng, Chuanxiong and Chuanwu are crushed into 100-150 meshes respectively.

8. The method for preparing red ginseng paste having a blood vessel softening effect according to claim 1, characterized in that: In step S2, the ethanol aqueous solution is 70-75% ethanol.

9. The method for preparing a red ginseng paste having a blood vessel softening effect according to claim 1, characterized in that: In step S4, the sterilization temperature is controlled at 80-95° C. and the sterilization time is 30 min.

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