Traditional Chinese medicine composition for removing spots and dredging collaterals, traditional Chinese medicine extract and application of traditional Chinese medicine composition and traditional Chinese medicine extract

Abstract

The invention discloses a traditional Chinese medicine composition for removing spots and dredging collaterals, a traditional Chinese medicine extract and application thereof, and belongs to the field of traditional Chinese medicine, the traditional Chinese medicine composition for removing spots and dredging collaterals is prepared from the following raw materials in parts by weight: 3-10 parts of pseudo-ginseng, 3-15 parts of thunberg fritillary bulb, 3-10 parts of leech, 2-5 parts of amber powder, 3-10 parts of ginseng, 3-6 parts of scorpio, 3-10 parts of ground beetle and 3-5 parts of storax; the traditional Chinese medicine extract for removing spots and dredging collaterals is extracted from the traditional Chinese medicine composition. The invention also discloses an application of the traditional Chinese medicine composition for removing spots and dredging collaterals or the traditional Chinese medicine extract for removing spots and dredging collaterals in preparation of medicines for treating carotid atherosclerosis. The traditional Chinese medicine composition is simple in formula, has excellent effects of removing spots and dredging collaterals, has an excellent treatment effect on carotid atherosclerosis, and does not have the conditions of unstable blood pressure and dizziness in the medicine taking period.

Description

Technical Field

[0001] The invention relates to a Chinese medicine composition for removing spots and unblocking meridians, a Chinese medicine extract and application thereof, and belongs to the field of Chinese medicine. Background Art

[0002] Carotid atherosclerosis is a common clinical disease, which is the manifestation of systemic atherosclerosis in the carotid artery. It usually occurs in adolescence and gradually worsens with age. Existing studies have found that it is closely related to the occurrence of ischemic stroke in the elderly. In the early stage of carotid atherosclerosis, the first manifestation is the thickening of the intima-media membrane, and then the atherosclerotic plaque is gradually formed. On this basis, intraplaque hemorrhage, plaque rupture and detachment, mural thrombosis and secondary vascular stenosis occur, causing corresponding hemodynamic changes and leading to the occurrence of ischemic cerebrovascular events.

[0003] At present, the treatment of carotid atherosclerosis by western medicine mainly includes anti-platelet aggregation, lipid regulation and plaque stabilization, anti-inflammation and other aspects, but these western medicines often have certain side effects. For example, statins can play a role in preventing and treating carotid atherosclerosis to varying degrees when used clinically, but the liver and kidney damage caused by long-term use of these drugs should not be underestimated.

[0004] Compared with the side effects of western medicine, traditional Chinese medicine has great advantages in treating carotid atherosclerosis. The prior art discloses a lot of drugs or compositions for treating carotid atherosclerosis and cardiovascular and cerebrovascular diseases.

[0005] For example, the publication number CN102423437A is a dual-component medicine for treating hemiplegia caused by stroke and its preparation method, which is composed of 5 to 10 parts by weight of formula A and 3 to 9 parts by weight of formula B, wherein the formula A is composed of extracts of Eupolyphagia sinensis, scorpion extracts, gecko extracts, centipede extracts, Morinda officinalis extracts, Cistanche deserticola extracts, processed frankincense extracts, leech extracts, processed aconite extracts, roasted pangolins, storax, benzoin, borneol, musk, realgar, toad venom, artificial bezoar, pearl powder, antler slices, black plum meat, Lingyi spore powder, processed strychnos nux vomica powder, chitosan oligosaccharides, grape seed extracts, resveratrol, epimedium extracts, ginseng extracts, Lysimachia scrotum extracts, Hedyotis diffusa extracts, and Scutellaria barbata extracts. The formula B is composed of raw hawthorn extract, Guangmuxiang extract, Astragalus extract, Clematis extract, red date extract, Achyranthes bidentata extract, Rhizoma Dioscoreae extract, Morinda officinalis extract, Psoralea corylifolia extract, Dipsacus asper extract, Pueraria root extract, Cinnamon bark extract, Schisandra chinensis extract, Angelica sinensis extract, Chuanxiong extract, Red Peony extract, Peach kernel extract, Carthamus tinctorius extract, Polygonum multiflorum extract, Eucommia ulmoides extract, Fritillaria cirrhosa extract, Taiwania lappa extract, Rehmannia glutinosa extract, raw malt extract, Ligustrum lucidum extract, Bupleurum extract, Lycium barbarum extract, Evodia rutaecarpa extract, Rhizoma Anemarrhenae extract, Asparagus cochinchinensis extract, Artemisia capillaris extract, Gastrodia elata extract, Morinda officinalis extract, chitosan oligosaccharide, and Panax notoginseng powder. The present invention has the advantages of improving the treatment and prevention level of cerebral apoplexy, reducing the incidence, disability rate and mortality rate of cerebral apoplexy, and having a high total effective rate.

[0006] For example, the publication number CN115350250A is a ginseng leech anti-freckle and blood stasis preparation and its preparation method. The ginseng leech anti-freckle and blood stasis preparation is made of the following raw materials: 10-100 parts of ginseng, 10-100 parts of astragalus, 10-100 parts of angelica, 10-80 parts of notoginseng, 10-100 parts of salvia miltiorrhiza, 10-70 parts of amber, 10-100 parts of cassia twig, 10-100 parts of chuanxiong, 10-80 parts of storax, 10-80 parts of aucklandia, 10-80 parts of nardus, 10-80 parts of dandruff, 10-100 parts of polygonatum, 10-80 parts of leech, 10-80 parts of sandalwood, 10-50 parts of borneol, 10-50 parts of cinnabar, 1080 parts of scorpion, 10-80 parts of centipede, 10-100 parts of poria, 10-100 parts of Poria, 10-100 parts of Alisma, 10-80 parts of processed Aconite, 10-100 parts of Gastrodia, 10-80 parts of Bupleurum, 10-80 parts of Achyranthes bidentata, 10-80 parts of Gouteng, 10-80 parts of Polygonatum odoratum, and 10-80 parts of Persica can promote blood circulation and remove blood stasis, dissolve plaques, soften blood vessels, invigorate qi and nourish blood, enhance myocardial power, assist yang, remove dampness and resolve phlegm, relieve qi and relieve pain, restore cardiovascular and cerebrovascular circulation function, achieve smooth blood circulation throughout the body, and can effectively treat coronary heart disease, myocardial infarction, angina pectoris, irritability and shortness of breath, chest and back pain, atrial fibrillation and premature beats, myocardial ischemia, cardiovascular and cerebrovascular sclerosis plaques, vascular stenosis, cerebral apoplexy, hemiplegia, limb numbness, hypertension, chronic hepatitis, prostatitis and other vascular soft and hard plaques, vascular congestion and other related diseases.

[0007] However, the above-mentioned prescriptions are relatively complicated, basically containing dozens of ingredients, which not only increases the burden on patients but also is inconvenient for preparation.

[0008] There are also Chinese medicine compositions with fewer ingredients, such as the Chinese medicine composition I for cardiovascular and cerebrovascular diseases disclosed in CN117224590A, which includes 400-700 parts by weight of Astragalus, 200-400 parts by weight of Panax notoginseng, 500-800 parts by weight of Ginkgo biloba, 100-350 parts by weight of Leech, 150-350 parts by weight of Pheretima, and 1-10 parts by weight of Borneol. Although the composition types are relatively few, it is currently in the animal experiment stage, and its clinical effect cannot be guaranteed: and the side contains Borneol, which is easy to volatilize if made into pills, and too much Astragalus, Leech, and Pheretima can replenish qi, break blood and activate blood circulation, which can easily cause unstable plates to fall off and bleed.

[0009] The "Clinical Observation of 200 Cases of Carotid Atherosclerosis Treated with Huaban Tongluo Recipe" published in Hunan Journal of Traditional Chinese Medicine, Li Haiying, Zhu Ke, Yang Yang, Handan Traditional Chinese Medicine Hospital, Hebei Province, published the formula of Panax notoginseng 3g, leech 8-10g, earthworm 12g, Fritillaria thunbergii 15g, amber powder 3g, borneol 1.5g. One dose per day, decoct and package by the automatic decoction machine of our hospital, 100mL / time, twice a day, morning and evening. This formula has a relatively good effect on the treatment of carotid atherosclerosis. After clinical observation of 200 cases, the total effective rate can reach 95%. However, in the process of the inventor using the prescription to treat carotid atherosclerosis, most patients complained that they would experience dizziness within one hour after taking the prescription in the morning and evening. The blood pressure monitoring during this period was basically: systolic pressure 150-160mmHg, diastolic pressure 90-105mmHg. One hour after taking the prescription, the blood pressure dropped to systolic pressure ≤140mmHg, diastolic pressure ≤90mmHg. In previous clinical observations, since most patients had symptoms of hypertension and some patients had symptoms of dizziness when they visited the doctor, it did not attract attention. In the subsequent application process, it was found that some patients whose blood pressure was maintained relatively stable by taking antihypertensive drugs on a daily basis also experienced symptoms of increased blood pressure and dizziness within one hour after taking the above prescription (still taking antihypertensive drugs). After statistics, among the 200 cases originally implemented clinically, 32 cases developed symptoms of increased blood pressure and dizziness within one hour after taking the above prescription. Among the subsequent 300 cases, 41 cases developed symptoms of increased blood pressure and dizziness within one hour after taking the above prescription (Control Group 2 in the embodiment), accounting for about 15%.

[0010] Patient: Zhou, female, 58 years old.

[0011] Date of first diagnosis: March 5, 2011.

[0012] Chief complaint: left limb weakness, headache, and dizziness for 10 days.

[0013] Current medical history: The patient suddenly had difficulty in moving the left limbs in the morning 10 days ago, accompanied by headache and dizziness, and then fell down, accompanied by difficulty in speaking, crooked mouth and eyes, and was hospitalized for treatment. A head CT scan confirmed that it was "cerebral infarction" and senile brain changes. The conventional anti-plate lipid-lowering, cerebral circulation improvement, blood pressure regulation, and complication prevention treatments given by Western medicine were ineffective. Current diagnosis: The patient is conscious, obese, has difficulty in moving the left limbs, needs help to walk, has difficulty walking, has a slurred speech, has a right corner of the mouth, and has a left tongue tip, accompanied by dizziness, insomnia, chest tightness and irritability, constipation, left limb muscle strength level I, weakened muscle tension, left Babinski sign (+), blood pressure: 130 / 80mmHg. The tongue is dark red, the sublingual collaterals are dark purple, the tongue coating is greasy and turbid, and the pulse is stringy and slippery.

[0014] TCM diagnosis: Stroke - affecting the meridians (phlegm and blood stasis, blocking the meridians).

[0015] Western medicine diagnosis: cerebral infarction.

[0016] Treatment method: Promote blood circulation, remove blood stasis, eliminate phlegm and dredge meridians.

[0017] Prescription: Panax notoginseng 3g, leech 8g, earthworm 12g, Fritillaria thunbergii 15g, amber powder 3g, borneol 1.5g. 7 doses, decocted in water.

[0018] Doctor's advice: Avoid greasy and light food; do appropriate rehabilitation exercises; keep a happy mood.

[0019] 30 minutes later, the blood pressure was measured at 150 / 100 mmHg, and the patient experienced worsening dizziness.

[0020] Patient: Chao, male, 53 years old.

[0021] First diagnosis date: November 3, 2022.

[0022] Chief complaint: Sudden aphasia and weakness of right upper limb for 3 hours.

[0023] Current medical history: The patient developed shortness of breath 2 hours ago, suddenly fell down, and could not speak. He was then treated in our hospital, and an emergency head CT scan was performed to rule out cerebral hemorrhage. Current main symptoms: lack of energy, drowsiness, good appetite recently, good sleep at night, and regular bowel movements. Dark red tongue, red tip of tongue, thin and moist fur, and thin and rapid pulse. Physical examination: blood pressure 125 / 75mmHg, heart rate 80 beats / min, heart sounds of varying strength, absolutely irregular heart rhythm, and no pathological murmurs were heard in the auscultation area of ​​each valve. Neurological examination: drowsiness, expressive aphasia. Shallow nasolabial groove on the right side, left corner of mouth deviated. Unable to extend tongue. Right upper limb muscle strength level II, right lower limb muscle level IV. Left limb muscle strength is normal. Limb tendon reflexes (++). Right Babinski sign (+). On the second day of admission, the symptoms worsened, and the right lower limb muscle strength decreased to level III.

[0024] TCM diagnosis: Stroke – affecting the internal organs (phlegm and heat covering the orifices).

[0025] Western medicine diagnosis: cerebral infarction.

[0026] Treatment method: resolve phlegm, open the orifices and eliminate freckles.

[0027] Prescription: Panax notoginseng 3g, leech 10g, earthworm 12g, Fritillaria thunbergii 15g, amber powder 3g, borneol 1.5g. 5 doses, decocted in water.

[0028] After taking this prescription orally for 30 minutes, the blood pressure increased to 160 / 100 mmHg and dizziness occurred. Summary of the invention

[0029] In order to solve the above technical problems, the present invention provides a Chinese medicine composition for removing spots and unblocking meridians, a Chinese medicine extract and its application. The Chinese medicine composition and the Chinese medicine extract have simple formulations, excellent effects of removing spots and unblocking meridians, and excellent therapeutic effects on carotid atherosclerosis. At the same time, blood pressure instability and dizziness will not occur during medication.

[0030] In order to solve the above technical problems, the first technical solution adopted by the present invention is:

[0031] A Chinese medicinal composition for removing spots and unblocking meridians is composed of the following raw materials in parts by weight: 3-10 parts of Panax notoginseng, 3-15 parts of Fritillaria thunbergii, 3-10 parts of leech, 2-5 parts of amber powder, 3-10 parts of ginseng, 3-6 parts of scorpion, 3-10 parts of earthworm and 3-5 parts of storax.

[0032] In order to solve the above technical problems, the second technical solution adopted by the present invention is:

[0033] A method for preparing a Chinese medicine composition for removing spots and unblocking meridians is prepared by mixing notoginseng, fritillaria thunbergii, leech, amber powder, ginseng, scorpion, earthworm and storax.

[0034] In order to solve the above technical problems, the third technical solution adopted by the present invention is:

[0035] A Chinese medicine extract for removing spots and unblocking meridians is obtained by extracting the Chinese medicine composition according to claim 1.

[0036] In order to solve the above technical problems, the fourth technical solution adopted by the present invention is:

[0037] Application of a Huaban Tongluo Chinese medicine composition or a Huaban Tongluo Chinese medicine extract in preparing a medicine for treating carotid atherosclerosis.

[0038] In order to solve the above technical problems, the fifth technical solution adopted by the present invention is:

[0039] A medicine for treating carotid atherosclerosis, comprising the Chinese medicine composition according to claim 1 or the Chinese medicine extract according to claim 2.

[0040] Due to the adoption of the above technical solution, the technical progress achieved by the present invention is:

[0041] The Chinese medicine composition for removing spots and unblocking meridians of the present invention includes: the main drug scorpion, which can unblock meridians and disperse stagnation, and the Panax notoginseng, which can promote blood circulation, dissipate blood stasis and stop bleeding. The two drugs are combined to dredge blood vessels, and the Panax notoginseng can also stop bleeding to prevent excessive blood breaking. Leeches and earthworms can break blood and remove blood stasis, and amber powder can promote blood circulation. The three drugs are used as assistants to help the main drug to break blood, and the Fritillaria thunbergii is bitter and cold, can clear away heat and disperse stagnation, and the ginseng is used to invigorate qi. Qi can promote blood circulation and can attract blood, which can not only promote blood circulation, but also help the Panax notoginseng attract blood and stop bleeding. The storax is pungent and aromatic, is good at running around, and helps the drugs to reach the whole body. The Chinese medicine composition not only has excellent effect of removing spots and unblocking meridians, but also has excellent therapeutic effect on carotid atherosclerosis, and simultaneously overcomes the symptoms of unstable blood pressure and dizziness after taking the medicine.

[0042] Pharmacological action: Qi deficiency and blood stasis are the root causes of atherosclerotic plaques. Treatment should focus on pathological factors such as phlegm, stasis, and toxins. The present invention mainly promotes blood circulation and supplements qi and disperses stagnation by comprehensively applying the principles of resolving phlegm, removing stasis, detoxifying, and clearing turbidity.

[0043] Modern pharmacology: Leeches have anticoagulant and antithrombotic effects. The pharmacological effects of Panax notoginseng are to nourish blood and qi and improve immunity. The main component is saponin, which has a blood circulation effect. Another component is the amino acid Panax notoginseng, which is a water-soluble non-protein amino acid and a special amino acid. It is the pharmacological material basis of Panax notoginseng's hemostatic effect. Eupolyphaga sinensis can promote angiogenesis and improve local blood circulation. The fibrinolytic active protein component of Eupolyphaga sinensis has an anti-thrombotic effect. The combined use of many drugs can achieve the therapeutic goals of dredging collaterals and activating blood circulation. It not only has excellent plaque removal and collateral dredging effects, but also has excellent therapeutic effects on carotid atherosclerosis. At the same time, it overcomes the symptoms of unstable blood pressure and dizziness after taking the medicine. BRIEF DESCRIPTION OF THE DRAWINGS

[0044] Figure 1 This is the ultrasound image at the first visit in Case 1 of the present invention;

[0045] Figure 2 This is the ultrasound image after half a year in Case 1 of the present invention;

[0046] Figure 3 This is the ultrasound image at the first visit in Case 2 of the present invention;

[0047] Figure 4 This is the ultrasound image after half a year in Case 2 of the present invention;

[0048] Figure 5 This is the ultrasound image at the first visit in Case 3 of the present invention;

[0049] Figure 6 This is the ultrasound image after half a year in Case 3 of the present invention;

[0050] Figure 7 This is the ultrasound image at the first visit in case 4 of the control group;

[0051] Figure 8This is the ultrasound image of Case 4 in the control group six months later. DETAILED DESCRIPTION

[0052] The following describes the embodiments of the present invention through specific examples, and those skilled in the art can understand the advantages and effects of the present invention from the contents of this specification. The present invention can also be implemented or applied through other different specific embodiments, and the details in this specification can also be modified or changed in various ways based on different viewpoints and applications without departing from the spirit of the present invention.

[0053] Before further describing the specific embodiments of the present invention, it should be understood that the scope of protection of the present invention is not limited to the specific embodiments described below; it should also be understood that the terms used in the examples of the present invention are for describing specific embodiments rather than for limiting the scope of protection of the present invention.

[0054] When the embodiment gives a numerical range, it should be understood that, unless otherwise specified in the present invention, the two endpoints of each numerical range and any numerical value between the two endpoints can be selected. Unless otherwise defined, all technical and scientific terms used herein have the same meanings as those of ordinary skill in the art to which the present invention belongs.

[0055] The present invention does not limit the sources of the raw materials used. Unless otherwise specified, the raw materials used in the present invention are common commercial products in the technical field.

[0056] Embodiment 1: Chinese medicine composition for removing spots and dredging meridians

[0057] 5g of Panax notoginseng, 10g of Fritillaria thunbergii, 5g of leech, 2g of amber powder (taken with water), 10g of ginseng, 3g of whole scorpion, 3g of earthworm, and 3g of storax; decocted in water and taken orally.

[0058] Embodiment 2: Chinese medicine composition for removing spots and dredging meridians

[0059] 3g of Panax notoginseng, 15g of Fritillaria thunbergii, 3g of leech, 3g of amber powder (taken with water), 7g of ginseng, 5g of whole scorpion, 8g of earthworm, 3g of storax; decocted in water and taken orally.

[0060] Embodiment 3: Chinese medicine composition for removing spots and dredging meridians

[0061] 8g of Panax notoginseng, 8g of Fritillaria thunbergii, 8g of Leech, 5g of amber powder (taken with water), 5g of ginseng, 6g of scorpion, 10g of Eupolyphaga sinensis, and 5g of Styrax osmanthus; decocted in water and taken orally.

[0062] Embodiment 4: Chinese medicine composition for removing spots and dredging meridians

[0063] 10g of Panax notoginseng, 3g of Fritillaria thunbergii, 10g of Leech, 3g of amber powder (taken with water), 5g of ginseng, 3g of scorpion, 5g of Eupolyphaga sinensis, and 4g of Styrax osmanthus. Decoction in water.

[0064] Embodiment 5: Chinese medicine composition for removing spots and dredging meridians

[0065] 10g of Panax notoginseng, 13g of Fritillaria thunbergii, 5g of leech, 3g of amber powder (taken with water), 8g of ginseng, 3g of whole scorpion, 3g of earthworm, and 3g of storax; decocted in water and taken orally.

[0066] Clinical trials:

[0067] Case selection:

[0068] The present invention selected 500 outpatients and inpatients (first visit) of the Department of Encephalopathy from January 2023 to December 2023, and divided them into 2 groups according to the random number table method. Among the 250 cases in the treatment group, there were 128 males and 122 females; the average age was (61.0±6.4) years old; 89 cases with hypertension, 25 cases with diabetes, and 58 cases with hyperlipidemia. Among the 250 cases in the control group, there were 126 males and 124 females; the average age was (59.0±6.8) years old; 93 cases with hypertension, 24 cases with diabetes, and 55 cases with hyperlipidemia. The general data of the two groups were compared, and the difference was not statistically significant (P>0.05), and they were comparable. Meanwhile, the 300 cases mentioned in the background technology who took the previous prescription were the control group 2, including 156 males and 144 females; the average age was (60.0±5.2) years old; 152 cases had hypertension, 112 cases had diabetes, and 61 cases had hyperlipidemia.

[0069] Diagnostic criteria

[0070] The diagnostic standard of Western medicine is formulated with reference to Ultrasound Medicine. The intima-media thickness (IMT) of the distal common carotid artery, the carotid bifurcation and the proximal internal carotid artery is tested: the thickness of the normal carotid intima is 0.1-0.5 mm, and when IMT ≥ 1.0 mm, it is abnormal. If IMT ≥ 1.3 mm and bulges into the blood vessel cavity, it should be determined as plaque formation.

[0071] The TCM syndrome differentiation standards were formulated with reference to the "Symptoms and Efficacy Evaluation of New Chinese Medicines" and the "Symptoms Section of TCM Clinical Diagnosis and Treatment Terminology".

[0072] Efficacy observation

[0073] Observation indicators: (1) IMT measurement: the average media thickness at the bifurcation, proximal end and distal end of the carotid artery at 1-2 cm was measured; (2) Plaque score measurement: the carotid atherosclerotic plaque score was calculated using the Crouse scoring method. The maximum thickness of the atherosclerotic plaques in the ipsilateral CCA, bifurcation, ICA and external carotid artery was added together to obtain the carotid plaque score. The total plaque score was obtained by adding the plaque scores of the carotid arteries on both sides; (3) TCM syndrome score: the score was scored according to the "Symptoms and Efficacy Evaluation of New Chinese Medicines". The main symptoms were scored as 6, 4, 2 and 0 points for severe, moderate, mild and normal, respectively, and the secondary symptoms were scored as 3, 2, 1 and 0 points, respectively.

[0074] Efficacy criteria

[0075] The criteria for evaluating the symptoms and efficacy of new Chinese medicines are used. Cured: symptoms and signs disappear or basically disappear, and the symptom score decreases by ≥95%; markedly effective: symptoms and signs are significantly improved, and the symptom score decreases by ≥70% but <95%; effective: symptoms and signs are improved, and the symptom score decreases by ≥30% but <70%; ineffective: symptoms and signs are not significantly improved, or even aggravated, and the symptom score decreases by ≤30%.

[0076] Side effect criteria

[0077] Blood pressure rises to ≥140 / 90 mmHg within 1 hour, or the systolic blood pressure rises by 20 mmHg and the diastolic blood pressure rises by 10 mmHg on the basis of the original blood pressure.

[0078] Inclusion criteria

[0079] They met the above-mentioned Western medical diagnostic criteria and TCM syndrome differentiation, voluntarily participated and signed the informed consent.

[0080] Exclusion criteria

[0081] (1) Failure to meet the diagnostic criteria; (2) Allergy to statins and intolerance to their side effects; (3) Poor compliance.

[0082] Treatment

[0083] The control group 1 received conventional western medicine treatment. Atorvastatin calcium tablets (produced by Pfizer Pharmaceuticals Co., Ltd., approval number: National Medicine Standard H20051408, specification: 20 mg / tablet) 20 mg was taken orally, once a day, at night.

[0084] Control group 2 used the previous prescription: 3g of Panax notoginseng, 8-10g of leech, 12g of earthworm, 15g of Fritillaria thunbergii, 3g of amber powder, and 1.5g of borneol. One dose per day, decocted in water, 100mL / time, twice a day, morning and evening.

[0085] The treatment group took the Huaban Tongluo prescription of Example 1 to Example 5. One dose per day, decocted in water, 100 mL / time, twice a day, morning and evening.

[0086] The efficacy of the three groups was observed after 6 months of treatment. The treatment results are shown in Table 1 below:

[0087] Table 1 Treatment results

[0088]

[0089] Case 1:

[0090] Patient: Mr. Li, male, 76 years old.

[0091] First diagnosis date: December 23, 2023.

[0092] Chief complaint: Intermittent left limb mobility problems for 2 days.

[0093] Current medical history: The patient had difficulty in moving the left limbs and slurred speech 2 days ago due to emotional disorder. The symptoms disappeared automatically after 5 minutes, but the patient did not pay attention to it. This morning, the symptoms recurred, with difficulty in moving the left limbs, crooked mouth and tongue, slurred speech, numbness on one side of the body, and dizziness. The symptoms disappeared after about 10 minutes, and the patient came for treatment. Current main symptoms: facial flushing, irritability, dark red tongue, ecchymosis on the edges of the tongue, thin white tongue coating, and sluggish pulse. Ultrasound examination was performed, such as Figure 1 As shown, a low-echo plaque of 42.6*3.1 mm was seen at the bifurcation of the common carotid artery, with a total plaque score of 59.2.

[0094] TCM diagnosis: Precursor of stroke (liver yang transforming into wind, blood stasis).

[0095] Western medicine diagnosis: transient ischemic attack.

[0096] Treatment principle: Promote blood circulation, remove blood stasis, eliminate spots and activate collaterals.

[0097] Prescription: 5g of Panax notoginseng, 10g of Fritillaria thunbergii, 5g of leech, 2g of amber powder, 10g of ginseng, 3g of scorpion, 3g of Eupolyphaga sinensis, and 3g of Styrax (Example 1).

[0098] Take 5 doses, decocted in water.

[0099] Doctor's instructions: Regulate your emotions, take the above medicine regularly, and follow up if you feel unwell.

[0100] Blood pressure was measured half an hour after taking the medicine, and the results were 126 / 82mmHg, 130 / 80mmHg, 127 / 85mmHg, 125 / 83mmHg, and 130 / 80mmHg respectively.

[0101] Second visit: December 28, 2023. During the 5 doses of oral medication, the patient had no symptoms, no special discomfort, dark tongue, thin white fur, stringy pulse, and symptom score decreased by ≥70%. Continue to take the prescription, 7 doses, decocted in water,

[0102] Blood pressure was tested half an hour after taking the medicine, and the results were: 129 / 83mmHg, 128 / 82mmHg, 130 / 82mmHg, 129 / 82mmHg, 130 / 84mmHg, 130 / 80mmHg, and 125 / 80mmHg.

[0103] Third visit: January 3, 2024. During the period of taking the medicine, the patient had no symptoms, no special discomfort, dark tongue, thin white fur, and stringy pulse. The symptom score decreased by ≥80%. Continue to take the above treatment.

[0104] Treatment results on June 6, 2024: The patient had no symptoms, no special discomfort, dark tongue, thin white fur, and stringy pulse. No increase in blood pressure occurred within half an hour of taking the medicine. Ultrasound testing was also performed, such as Figure 2 As shown, a hypoechoic plaque of 21.6*1.5 mm was seen at the bifurcation of the common carotid artery, with a total plaque score of 30.6 and a symptom score reduction of ≥100%.

[0105] Case 2

[0106] Patient: Mr. Li, male, 79 years old.

[0107] First diagnosis date: December 30, 2023.

[0108] Chief complaint: Spinning vision and nausea for 3 days.

[0109] Current medical history: The patient had visual rotation without obvious cause 3 days ago. He went to the local hospital and was diagnosed with "transient ischemic attack". He received infusion treatment but did not improve. He sought Chinese medicine treatment. Current main symptoms: visual rotation, unstable gait, intermittent, accompanied by nausea and vomiting. When the attack occurs, it is slightly more comfortable to close the eyes. The lips are purple and dark, amnesia, occasional tinnitus, dark tongue, petechiae on the sides of the tongue, and stringy pulse. Ultrasound examination showed Figure 3 As shown, strong and mixed hypoechoic plaques measuring 9.3*2.4mm were seen at the bifurcation of bilateral common carotid arteries, with a total plaque score of 11.7.

[0110] Traditional Chinese Medicine diagnosis: vertigo (Qi stagnation and blood stasis).

[0111] Western medicine diagnosis: transient ischemic attack.

[0112] Treatment method: Promote blood circulation, remove blood stasis, eliminate spots and activate collaterals.

[0113] Prescription: 3g of Panax notoginseng, 15g of Fritillaria thunbergii, 3g of leech, 3g of amber powder, 7g of ginseng, 5g of scorpion, 8g of Eupolyphaga sinensis, 3g of Styrax (Example 2). 7 doses, decocted in water.

[0114] Doctor's advice: Avoid spicy food, do not eat too much; keep a happy mood.

[0115] The blood pressure was checked half an hour after taking the medicine, and the results were 115 / 80mmHg, 120 / 80mmHg, 115 / 75mmHg, 115 / 80mmHg, and 120 / 75mmHg respectively.

[0116] Second visit: January 5, 2024. After taking 7 doses of the above medicine, the patient's vision was spinning and nausea and vomiting were significantly improved. In the past 2 days, he had dizziness, tinnitus improved, cough and poor appetite, tongue became light red, the number of petechiae on the tongue decreased, and pulse was stringy. The symptom score decreased by ≥60%.

[0117] The prescription is as follows: 5g of Panax notoginseng, 10g of Fritillaria thunbergii, 8g of leech, 2g of amber powder, 10g of ginseng, 3g of scorpion, 3g of earthworm, 3g of storax. Decoction in water.

[0118] Treatment results on June 4, 2024: Vision spinning, nausea and vomiting have not occurred, forgetfulness has improved, tinnitus occasionally occurs, tongue is light red, petechiae around the tongue have significantly decreased, pulse is stringy. No blood pressure has increased within half an hour of taking the medicine. Ultrasound detection Figure 4 As shown, strong and mixed hypoechoic plaques of 4.5*1.2 mm were seen at the bifurcation of bilateral common carotid arteries, with a total plaque score of 5.7 and a symptom score reduction of ≥90%.

[0119] Case 3

[0120] Patient: Yao, female, 55 years old.

[0121] Date of first diagnosis: December 9, 2023.

[0122] Chief complaint: Sudden aphasia and weakness of right upper limb for 3 hours.

[0123] Current medical history: The patient developed shortness of breath 3 hours ago, suddenly fell down, and could not speak. Urgent head CT scan ruled out cerebral hemorrhage. Current main symptoms: lack of energy, drowsiness, good appetite recently, good sleep at night, and regular bowel movements. Dark red tongue, red tip, thin and moist fur, thready and rapid pulse. Physical examination: blood pressure 150 / 100mmHg, heart rate 106 beats / min, heart sounds of varying strengths, absolutely irregular heart rhythm, no pathological murmurs heard in the auscultation areas of the valves. Neurological examination: drowsiness, expressive aphasia. Shallow right nasolabial groove, left corner of mouth deviated. Unable to extend tongue. Right upper limb muscle strength grade II, right lower limb muscle grade IV. Normal left limb muscle strength. Limb tendon reflexes (++). Right Babinski sign (+). Symptoms worsened on the second day of hospitalization, and the right lower limb muscle strength was reduced to grade III. A low-echoic plaque with a range of approximately 3.9*1.5mm can be seen at the bifurcation of the brachiocephalic trunk, such as Figure 5 As shown, total plaque score: 5.4.

[0124] TCM diagnosis: Stroke – affecting the internal organs (phlegm and heat covering the orifices).

[0125] Western medicine diagnosis: cerebral infarction.

[0126] Treatment method: Promote blood circulation, remove blood stasis, dissolve spasms and activate collaterals.

[0127] Prescription: Panax notoginseng 5g, Fritillaria thunbergii 10g, Leech 8g, Amber powder 2g, Ginseng 10g, Scorpion 3g, Eupolyphaga sinensis 3g, Styrax 3g. 7 doses, decocted in water. No antihypertensive treatment.

[0128] Doctor's advice: Avoid greasy food, feed a light diet through nasogastric feeding, turn over and pat the back regularly; keep bowel movements smooth; pay attention to bedside rehabilitation exercises.

[0129] Blood pressure was checked half an hour after taking the medicine, and the results were 150 / 100mmHg, 153 / 100mmHg, 155 / 101mmHg, 150 / 101mmHg, and 150 / 100mmHg respectively.

[0130] Second visit: December 16, 2023. After taking 7 doses of the above prescription, the patient was conscious, not energetic, had an increased appetite, could speak a little, had weak right limbs, had no bowel movements, and had regular urination. The tongue was red, with little coating, and the pulse was thin and knotty. The symptom score decreased by ≥30%. Continue to take the above prescription and take antihypertensive drugs at the same time for antihypertensive treatment.

[0131] Blood pressure was checked half an hour after taking the medicine, and the results were 129 / 86mmHg, 130 / 85mmHg, 128 / 83mmHg, 130 / 83mmHg, and 129 / 80mmHg respectively.

[0132] Third visit: December 23, 2023. After taking 7 doses of the medicine, the patient's speech increased, the right limbs were stronger than before, and he could walk independently. His appetite was good, his sleep was good, and his bowel movements were normal. The tongue was red, the coating was peeled, and the pulse was thin and knotty. The muscle strength of the upper and lower limbs on the right side was grade IV.

[0133] Treatment results on June 2, 2024: The patient's family reported that the patient could basically take care of himself. No increase in blood pressure occurred within half an hour of taking the medication. A low-echo plaque of about 1.8*0.9mm was visible at the bifurcation of the brachiocephalic trunk. Figure 6 The total plaque score was 2.7, and the symptom score was reduced by ≥80%.

[0134] Case 4 (Control Group)

[0135] Patient: Mr. Cao, male, 61 years old.

[0136] Date of first diagnosis: February 26, 2024.

[0137] Chief complaint: right hemiplegia for 2 days.

[0138] Current medical history: The patient developed right limb weakness due to fatigue 2 days ago, accompanied by right limb numbness, left-sided mouth corner deviation, drooling, fever, fear of cold, normal appetite and sleep, normal bowel movements, and brain CT showed: left basal ganglia cerebral infarction, pale red tongue with white greasy coating, and floating pulse. At the same time, ultrasound examination showed strong and mixed echo plaques in the bilateral carotid bifurcation, internal carotid artery, and left common carotid and external carotid arteries, and a large area of ​​about 12.9*2.9mm low echo plaques, such as Figure 7 As shown, total plaque score: 15.3.

[0139] TCM diagnosis: Stroke - affecting the meridians (wind and phlegm blocking the meridians).

[0140] Western medicine diagnosis: cerebral infarction.

[0141] The patient was given atorvastatin calcium 20 mg, 1 / day, orally before bedtime.

[0142] Treatment results on June 9, 2024: The patient reported that after taking the medicine for 6 months, his mouth was still crooked and drooling, and he had fever and no chills. His stool was slightly dry, his tongue was pale red with white fur, and his pulse was floating and slippery. Ultrasound examination showed that strong and mixed echo plaques were seen in the bilateral carotid bifurcation, internal carotid artery, and left common carotid and external carotid arteries, and a large area of ​​about 12.9*2.9mm low echo plaques, such as Figure 8 As shown, total plaque score: 15.3, no change.

Claims

1. A Chinese medicine composition for removing spots and dredging meridians, characterized in that: The invention is composed of the following raw materials in parts by weight: 3-10 parts of Panax notoginseng, 3-15 parts of Fritillaria thunbergii, 3-10 parts of leech, 2-5 parts of amber powder, 3-10 parts of ginseng, 3-6 parts of scorpion, 3-10 parts of earthworm and 3-5 parts of storax.

2. A method for preparing a Chinese medicine composition for removing spots and dredging meridians as claimed in claim 1, characterized in that: The product is prepared by mixing Panax notoginseng, Fritillaria thunbergii, leech, amber powder, ginseng, scorpion, earthworm and styrax according to the formula.

3. A Chinese medicine extract for removing spots and dredging meridians, characterized in that: Obtained by extracting the Chinese medicine composition according to claim 1.

4. Use of the Huaban Tongluo Chinese medicine composition according to claim 1 or the Huaban Tongluo Chinese medicine extract according to claim 3 in the preparation of a medicament for treating carotid atherosclerosis.

5. A drug for treating carotid atherosclerosis, characterized in that: Including the Chinese medicine composition according to claim 1 or the Chinese medicine extract according to claim 3.

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