A sequential balloon pulsating blood pump, system and method for artificial uterus

Abstract

The present invention provides a sequential balloon pulsating blood pump, system and method for an artificial uterus, and relates to the technical field of medical devices. The blood pump comprises: a pump body, which is arranged in the blood flow circuit of the artificial placenta, and the pump body comprises a first pump chamber and a second pump chamber; the first pump chamber and the second pump chamber are connected in parallel through a catheter, and the two ends of the catheter are respectively the inlet end and the outlet end of the blood, the inlet end is connected to the umbilical artery of the fetus, and the outlet end is connected to the umbilical vein of the fetus through an oxygenator; a controller, and the controller is respectively connected to the first airbag assembly and the second airbag assembly in communication; a heart collection unit, and the heart collection unit is arranged on the outer surface of the artificial uterus and is connected to the controller in communication. The present invention can generate pulsating blood flow, can adapt to the high heart rate of the fetus, and does not affect the afterload balance of the fetal heart, and avoids the advantages of umbilical blood vessel cannulation spasm.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a sequential balloon pulsating blood pump, system and method for an artificial uterus. Background Art

[0002] Extreme preterm birth remains a major cause of neonatal mortality and severe long-term morbidity. The basic principle of artificial placenta (AP) and uterus (AW) technology is a more physiological approach, which replaces the placenta function and provides a uterine-like environment. In the artificial placenta circuit, the blood pump is one of its core parts, which overcomes the oxygenator resistance and provides power for blood to flow in the tube to restore physiological fetal flow.

[0003] At present, the blood pumps used in artificial placentas are mainly roller pumps and centrifugal pumps. Whether it is a centrifugal pump or a roller pump, the suction force will interfere with the natural heart pump function during the process of discharging blood from the fetal heart, resulting in afterload imbalance and heart strain. In addition, since the fetal umbilical artery and vein are relatively thin, constant flow pumps are prone to cause umbilical artery and vein spasm. Summary of the invention

[0004] In order to solve the existing problems in the prior art, whether it is a centrifugal pump or a roller pump, the suction force will interfere with the natural heart pump function during the process of discharging fetal heart blood, resulting in afterload imbalance and heart strain. In addition, since the fetal umbilical artery and vein are relatively thin, the constant flow pump is prone to cause umbilical artery and vein spasm. The embodiment of the present invention provides a sequential balloon pulsating blood pump, system and method for an artificial uterus. The technical solution is as follows:

[0005] In one aspect, a sequential balloon pulsation blood pump for an artificial uterus is provided, the blood pump comprising:

[0006] A pump body, the pump body is arranged in the blood flow circuit of the artificial placenta, the pump body comprises a first pump chamber and a second pump chamber;

[0007] Wherein, a first airbag assembly is arranged in the first pump chamber, and the first airbag assembly includes a first balloon, a second balloon and a third balloon which are arranged in sequence;

[0008] A second airbag assembly is disposed in the second pump chamber, and the second airbag assembly includes a fourth balloon, a fifth balloon and a sixth balloon which are disposed in sequence;

[0009] The first pump chamber and the second pump chamber are connected in parallel via a catheter, and the two ends of the catheter are respectively an inlet end and an outlet end of blood, the inlet end is connected to the umbilical artery of the fetus, and the outlet end is connected to the umbilical vein of the fetus via an oxygenator;

[0010] A controller, the controller being in communication connection with the first airbag assembly and the second airbag assembly respectively;

[0011] A heart collection unit is arranged on the outer surface of the artificial uterus and is communicatively connected with the controller.

[0012] Optionally, the volume of the second balloon after expansion is greater than the volume of the first balloon and the third balloon after expansion.

[0013] Optionally, the volume of the fifth balloon after expansion is greater than the volume of the fourth balloon and the sixth balloon after expansion.

[0014] Optionally, the controller includes a regulating module, and the regulating module can adjust the beating frequency and beating intensity of the first airbag assembly and the second airbag assembly according to data provided by the heart acquisition unit.

[0015] Optionally, a pressure sensor is further provided in the pump body, and the pressure sensor is communicatively connected with the controller. The pressure sensor is used to obtain pressure data of the blood in the pump body, and the pressure data is sent to the controller.

[0016] Optionally, both ends of the catheter are provided with connecting joints for detachably connecting to the fetal umbilical artery and the oxygenator respectively.

[0017] Optionally, the pump body further comprises a temperature regulating device, which is disposed in the pump body and is used to regulate the temperature of the blood in the pump body.

[0018] On the one hand, a sequential balloon pulsating blood pump system for an artificial uterus is provided, comprising an artificial uterus, an oxygenator, and any one of the above-mentioned sequential balloon pulsating blood pumps for an artificial uterus;

[0019] The artificial uterus is used to accommodate the fetus, and the two ends of the catheter of the pump body are respectively the inlet end and the outlet end of the blood, and the inlet end is connected to the umbilical artery of the fetus.

[0020] On the one hand, a control method for a sequential balloon pulsating blood pump for an artificial uterus is provided, which is applied to any of the sequential balloon pulsating blood pumps for an artificial uterus described above, and the method comprises:

[0021] The pump body is arranged in the blood flow circuit of the artificial placenta;

[0022] Acquire the heart blood supply time and blood discharge time based on the heart acquisition unit, and send the blood supply time and blood discharge time to the controller;

[0023] The controller adjusts the beating frequency, beating intensity and beating sequence of at least one of the first airbag assembly and the second airbag assembly according to the data provided by the cardiac acquisition unit.

[0024] Optionally, the controller adjusts the beating frequency, beating intensity and beating sequence of at least one of the first airbag assembly and the second airbag assembly according to the data provided by the heart acquisition unit, including:

[0025] In the counterpulsation mode, the controller adjusts the beating frequency, beating intensity and beating sequence of the first airbag assembly according to the data provided by the heart acquisition unit;

[0026] In the synchronous mode, the controller adjusts the beating frequency, beating intensity and beating sequence of the first airbag assembly and the second airbag assembly respectively according to the data provided by the heart acquisition unit.

[0027] The beneficial effects brought about by the technical solution provided by the embodiment of the present invention include at least:

[0028] The sequential balloon pulsating blood pump for an artificial uterus provided by the present invention can generate pulsating blood flow by setting a first airbag assembly and a second airbag assembly, can adapt to the high heart rate of the fetus, does not affect the afterload balance of the fetal heart, and avoids the advantages of umbilical blood vessel catheter spasm. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0030] Figure 1 It is a working principle diagram of a sequential balloon pulsating blood pump for an artificial uterus provided by an embodiment of the present invention;

[0031] Figure 2 It is a structural diagram of a pump body 1 provided in an embodiment of the present invention;

[0032] Figure 3 This is one of the working principle diagrams of a pump body 1 provided in an embodiment of the present invention;

[0033] Figure 4 This is the second working principle diagram of a pump body 1 provided in an embodiment of the present invention;

[0034] Figure 5 is a flow chart of a sequential balloon pulsation method for an artificial uterus provided by an embodiment of the present invention;

[0035] Figure 6This is the third working principle diagram of a pump body 1 provided by an embodiment of the present invention;

[0036] Figure 7 This is the fourth working principle diagram of a pump body 1 provided in an embodiment of the present invention.

[0037] Reference numerals:

[0038] 1. Pump body; 10. First pump chamber; 110. First airbag assembly; 111. First balloon; 112. Second balloon; 113. Third balloon; 20. Second pump chamber; 210. Second airbag assembly; 211. Fourth balloon; 212. Fifth balloon; 213. Sixth balloon;

[0039] 2. catheter; 230. inlet end; 231. umbilical artery; 220. outlet end; 221. umbilical vein;

[0040] 3. Oxygenator;

[0041] 4. Controller;

[0042] 5. Heart collection unit;

[0043] 6. Gas source;

[0044] 7. Fetus

[0045] 8. Artificial womb. DETAILED DESCRIPTION

[0046] The technical solution of the present invention is described below in conjunction with the accompanying drawings.

[0047] In the embodiments of the present invention, words such as "exemplarily" and "for example" are used to indicate examples, illustrations or explanations. Any embodiment or design described as "example" in the present invention should not be interpreted as being more preferred or more advantageous than other embodiments or designs. Specifically, the use of the word "example" is intended to present the concept in a specific way. In addition, in the embodiments of the present invention, the meaning expressed by "and / or" can be both, or it can be either of the two.

[0048] In order to make the technical problems, technical solutions and advantages to be solved by the present invention more clear, a detailed description will be given below with reference to the accompanying drawings and specific embodiments.

[0049] The embodiment of the present invention provides a sequential balloon pulsating blood pump for an artificial uterus. Figure 1 This is a working principle diagram of a sequential balloon pulsating blood pump for an artificial uterus provided by an embodiment of the present invention, see Figure 1 The blood pump includes: a pump body 1, a controller 4 and a heart collection unit 5.

[0050] The pump body 1 is arranged in the blood flow circuit of the artificial placenta, the artificial placenta is located in the artificial uterus 8, and the pump body 1 is used to drive the circulation of blood. Figure 2 This is a structural diagram of a pump body 1 provided in an embodiment of the present invention, see Figure 2 The pump body 1 includes a first pump chamber 10 and a second pump chamber 20. A first airbag assembly 110 is disposed in the first pump chamber 10. When the first airbag assembly 110 expands, it pushes the blood in the pump chamber to flow out; when the first airbag assembly 110 contracts, it absorbs new blood. A second airbag assembly 210 is disposed in the second pump chamber 20. The working principle of the second airbag assembly 210 is the same as that of the first airbag assembly 110.

[0051] Specifically, the first airbag assembly 110 includes a first balloon 111, a second balloon 112 and a third balloon 113 arranged in sequence, and the second airbag assembly 210 includes a fourth balloon 211, a fifth balloon 212 and a sixth balloon 213 arranged in sequence. All balloons are fixed to the inner wall of the pump cavity through air guide tubes connected thereto, and each balloon is independent of each other, operates separately in the pump cavity, and expands and contracts in the pump cavity. Each balloon has a corresponding pump body 1 air source 6 as a driving device, and the airbag and the air source 6 are connected through an air guide tube. The contraction and expansion of the balloon are achieved by inflating and deflating it by a control device.

[0052] Furthermore, the first pump chamber 10 and the second pump chamber 20 are connected in parallel through the catheter 2, and the two ends of the catheter 2 are respectively the blood inlet end 230 and the outlet end 220, which constitute the blood circulation path. The inlet end 230 is connected to the umbilical artery 231 of the fetus 7, and is used to receive blood from the fetus 7. The outlet end 220 is connected to the umbilical vein 221 of the fetus 7 through the oxygenator 3. When the blood passes through the oxygenator 3, oxygen is supplemented and waste is removed, thereby simulating the oxygen exchange process of the fetus 7 in the mother's body.

[0053] The controller 4 is respectively connected in communication with the first airbag assembly 110 and the second airbag assembly 210. Specifically, the controller 4 is connected in communication with the air source 6 in the first airbag assembly 110 and the second airbag assembly 210 to control the expansion and contraction of the airbag assembly.

[0054] The heart acquisition unit 5 is arranged on the outer surface of the artificial uterus 8 and is in communication connection with the controller 4. The heart acquisition unit 5 can monitor the heartbeat of the fetus 7 in real time and transmit the data to the controller 4. The controller 4 adjusts the beating frequency and strength of the airbag assembly according to the data to ensure that the blood circulation is consistent with the heartbeat of the fetus 7. Therefore, the controller 4 can control the expansion and contraction of the airbag assembly according to the preset program and the data of the heart acquisition unit 5, thereby simulating the beating process of the heart.

[0055] When the blood pump is working, the controller 4 controls the expansion and contraction of the first airbag assembly 110 and the second airbag assembly 210 according to the data provided by the heart collection unit 5. For example, when the first airbag assembly 110 expands, it pushes the blood in the first pump chamber 10 to flow out and enter the oxygenator 3 through the catheter 2; at the same time, the second airbag assembly 210 contracts and inhales new blood. Then, the second airbag assembly 210 expands, pushing the blood in the second pump chamber 20 to flow out and enter the oxygenator 3 again; while the first airbag assembly 110 contracts and prepares to inhale new blood. In this way, the two airbag assemblies work alternately to achieve continuous circulation of blood.

[0056] Specifically, when the present invention is working, the two branches in the pump chamber can work simultaneously or separately. For example, when a single branch is working, after the first balloon 111 (or the fourth balloon 211) is contracted, the second balloon 112 (or the fifth balloon 212) is contracted, and the third balloon 113 (or the sixth balloon 213) is kept expanded, and low pressure is generated in the pump chamber to draw blood into the pump chamber; then the first balloon 111 (or the fourth balloon 211) is expanded, the second balloon 112 (or the fifth balloon 212) is inflated, the pressure in the pump chamber increases, the third balloon 113 (or the sixth balloon 213) is deflated and contracted, and blood is discharged from the outlet 220. When the double branches are working, the two branches work alternately.

[0057] It should be noted that the first balloon 111 is used to simulate the mitral valve and control the blood flowing into the first pump chamber 10, the second balloon 112 simulates the left ventricle and can simulate the contraction and relaxation of the left ventricle, and the third balloon 113 simulates the aortic valve and controls the blood flowing out of the first pump chamber 10. Figure 3 As shown, during the ventricular diastole, the first balloon 111 and the second balloon 112 are deflated, the blood inlet side of the first pump chamber 10 is opened, the third balloon 113 is inflated, the bleeding side of the first pump chamber 10 is closed, and blood flows into the first pump chamber 10. Figure 4 As shown, during the cardiac systole, the first balloon 111 is inflated, the blood inlet side of the first pump chamber 10 is closed, and at the same time, the third balloon 113 is deflated, and the second balloon 112 is inflated first, so that the blood in the first pump chamber 10 is gradually squeezed out from the blood inlet side to the outlet side. Then, the third balloon 113 is inflated, and the first balloon 111 and the second balloon 112 are deflated, and the blood flows back into the first pump chamber 10. This process is repeated to obtain pulsatile blood flow, completing its function of assisting the heart.

[0058] That is to say, by controlling the first airbag assembly 110 and the second airbag assembly 210 through the controller 4, a pulsating blood flow can be generated. The pulsating blood flow generated by the blood pump can adapt to the high heart rate of the fetus 7 without affecting the afterload balance of the heart of the fetus 7, avoiding the spasm of the umbilical blood vessel catheter, etc.

[0059] The blood pumping effect of the pulsating blood pump comes from the inflation and expansion of the balloon, which is softer than the rotation of the impeller, reduces the stimulation to the umbilical blood vessel wall, and can effectively avoid spasm during catheterization of the umbilical vein 221 and the umbilical artery 231.

[0060] Moreover, the heart rate of fetus 7 is relatively high, and the synchronous working mode of the pulsatile pump can adapt to the high heart rate of fetus 7. The working frequency of each pump is only half of the heart rate of fetus 7. Compared with the blood pump that relies on high-speed rotation of the rotor as a drive, the shear force generated by the present invention is significantly reduced, avoiding the problem of significantly increased hemolysis index caused by the high speed of the centrifugal pump.

[0061] The sequential balloon pulsating blood pump for an artificial uterus provided by the present invention can generate pulsating blood flow by setting a first airbag assembly 110 and a second airbag assembly 210, can adapt to the high heart rate of the fetus 7, does not affect the afterload balance of the fetus 7 heart, and avoids the advantages of umbilical blood vessel catheter spasm.

[0062] In the embodiment provided by the present invention, the pump body 1 has a pump housing, which is a cylindrical cavity structure, and its two ends are respectively the pump inlet end 230 and the outlet end 220. For each balloon, when shrinking, it can shrink by itself through the elasticity of the balloon itself, or it can shrink by extracting gas from the gas source 6, that is, the purpose of simulating balloon shrinkage can be achieved in various forms, and the purpose of controlling the expansion or contraction speed can be achieved by controlling the running speed of the gas source 6 during the working process.

[0063] The ECG acquisition unit may include an ECG acquisition patch, which is attached to the outer surface of the artificial uterus 8 without direct contact with the fetus 7. Based on the ECG data of the fetus 7 collected by the ECG acquisition patch, each gas source 6 is individually controlled, which is more scientific and intelligent. This unit is responsible for monitoring the activity of the heart, which may include key indicators such as heart rate, heart rhythm, and cardiac output. It transmits these data to the controller 4 in real time.

[0064] In one embodiment provided by the present invention, the volume of the second balloon 112 after expansion is greater than the volume of the first balloon 111 and the third balloon 113. The second balloon 112 can be used to occupy a larger space in the first pump chamber 10 to achieve control of blood flow.

[0065] In one embodiment provided by the present invention, the volume of the fifth balloon 212 after expansion is greater than the volume of the fourth balloon 211 and the sixth balloon 213. The fifth balloon 212 can be used to occupy a larger space in the first pump chamber 10 to achieve control of blood flow.

[0066] In one embodiment provided by the present invention, the controller 4 includes a regulating module, and the regulating module can adjust the beating frequency and beating intensity of the first airbag assembly 110 and the second airbag assembly 210 according to the data provided by the heart acquisition unit 5. In other words, the regulating module is capable of adjusting the beating parameters of the airbag assembly. The expansion and contraction of the airbag assembly is controlled based on the beating frequency and beating intensity collected by the heart acquisition unit 5, thereby simulating the beating process of the heart. For example, if the heart acquisition unit 5 shows that the heart rate is too low, the regulating module may increase the beating frequency of the airbag assembly to stimulate the heart. The adjusted airbag assembly will affect the heart state again, and the heart acquisition unit 5 will continue to monitor these changes and feed back the new data to the regulating module. In this way, a closed-loop feedback system is formed, which can continuously optimize the use effect of the pump body 1.

[0067] In one embodiment provided by the present invention, a pressure sensor is also provided in the pump body 1, and the pressure sensor is connected to the controller 4 for communication. The pressure sensor is used to obtain the pressure data of the blood in the pump body 1, and the pressure data is sent to the controller 4. The data detected by the pressure sensor can be used to understand the working state of the pump body 1, the blood flow and possible abnormalities. After receiving these data, the controller 4 analyzes and processes them. According to the analysis results, the controller 4 can adjust the parameters such as the pulsation frequency and pulsation intensity of the airbag assembly to ensure that the blood pressure in the pump body 1 remains within a safe and stable range.

[0068] Furthermore, if the controller 4 detects abnormal pressure data (such as too high or too low pressure values), it can immediately take measures, such as suspending the operation of the pump body 1, sounding an alarm, etc., to prevent possible damage or failure.

[0069] In one embodiment provided by the present invention, connecting joints are respectively provided at both ends of the catheter 2 for detachably connecting to the umbilical artery 231 of the fetus 7 and the oxygenator 3 respectively.

[0070] The catheter 2 is responsible for establishing a blood circulation channel between the umbilical artery 231 of the fetus 7 and the oxygenator 3. In addition, the connection joint is designed to be detachable, so that the catheter 2 can be easily connected to the target device and can also be easily removed without damaging the device.

[0071] In one embodiment provided by the present invention, the pump body 1 further includes a temperature regulating device, which is disposed in the pump body 1 and is used to regulate the temperature of the blood in the pump body 1. The temperature regulating device can ensure that the blood is kept within a preset temperature range during the circulation process, which is essential for maintaining the vital signs and treatment effects of the fetus 7. Once an abnormal temperature is detected, the temperature regulating device will be immediately activated to adjust the blood temperature back to the preset range by heating or cooling.

[0072] Specifically, the temperature adjustment device may be disposed at the inlet end 230 or the outlet end 220, which is not limited in this embodiment.

[0073] The blood pump is described in detail below:

[0074] The sequential balloon pulsating blood pump provided by the present invention includes a pump body 1 and a driving device thereof, wherein the driving device includes an air source 6 corresponding to the airbag, and the airbag and the air source 6 are connected through an air guide tube. The pump body 1 is mainly composed of a pump housing, a balloon, an air guide tube, and other parts. The pump body 1 is composed of two completely identical branches in parallel, the inlet end 230 of the pump is divided into two and extends to the two branches, and the outlets of the two branches are merged together to serve as the outlet end 220 of the pump as a whole.

[0075] Specifically, the inner radius of the branch tube is 10mm and the length is 100mm; the inner radius of the outlet end 220 and the inlet end 230 is 5mm, and the overall length of the pump is 160mm. The thickness of the pump shell is 3mm, and the balloons are all flexible balloons with good biocompatibility. The maximum expansion radius of the first balloon 111, the third balloon 113, the fourth balloon 211, and the sixth balloon 213 is slightly larger than the inner diameter of the tube 0, and the tube can be completely blocked after full expansion. The volume of the second balloon 112 and the fifth balloon 212 can be flexibly selected according to the actual cardiac output information of the fetus 7.

[0076] The sequential balloon pulsating blood pump for an artificial uterus provided by the present invention can generate pulsating blood flow by setting a first airbag assembly 110 and a second airbag assembly 210, can adapt to the high heart rate of the fetus 7, does not affect the afterload balance of the fetus 7 heart, and avoids the advantages of umbilical blood vessel catheter spasm.

[0077] The present invention also provides a sequential balloon pulsating blood pump system for an artificial uterus, comprising an artificial uterus 8, an oxygenator 3 and any of the above sequential balloon pulsating blood pumps for an artificial uterus;

[0078] The artificial uterus 8 is used to accommodate the fetus 7 , and the two ends of the catheter 2 of the pump body 1 are respectively an inlet end 230 and an outlet end 220 of blood, and the inlet end 230 is connected to the umbilical artery 231 of the fetus 7 .

[0079] The sequential balloon pulsation system for an artificial uterus provided by the present invention can generate pulsating blood flow by setting a first airbag assembly 110 and a second airbag assembly 210, can adapt to the high heart rate of the fetus 7, does not affect the afterload balance of the heart of the fetus 7, and avoids the advantages of umbilical blood vessel catheter spasm.

[0080] The present invention provides a control method for a sequential balloon pulsating blood pump for an artificial uterus, which is applied to any of the above-mentioned sequential balloon pulsating blood pumps for an artificial uterus. Figure 5is a flow chart of a sequential balloon pulsation method for an artificial uterus provided by an embodiment of the present invention, see Figure 5 , methods include:

[0081] 501. The pump body 1 is arranged in the blood flow circuit of the artificial placenta.

[0082] In this step, the blood pump is correctly installed in the blood flow system of the artificial placenta to ensure that the blood can circulate smoothly under the drive of the pump body 1. According to the design of the artificial placenta and the blood pump, the inlet and outlet of the pump body 1 are connected to the corresponding pipelines of the artificial placenta to form a complete blood flow circuit.

[0083] 502 . Acquire the heart blood supply time and blood discharge time based on the heart acquisition unit 5 , and send the blood supply time and blood discharge time to the controller 4 .

[0084] The heart acquisition unit 5 monitors the heart activity of the fetus 7 in real time to obtain accurate blood supply and blood discharge time information. Specifically, the heart acquisition unit 5 may include an ECG acquisition patch or other equipment capable of monitoring heart activity. These devices convert the collected heart activity data (such as heart rate, heart rhythm, etc.) into blood supply time and blood discharge time, and send them to the controller 4. This information can reflect the actual needs of the heart of the fetus 7.

[0085] 503 . According to the data provided by the heart acquisition unit 5 , the controller 4 adjusts the beating frequency, beating intensity and beating sequence of at least one of the first airbag assembly 110 and the second airbag assembly 210 .

[0086] The pulsation parameters of the airbag assembly are precisely adjusted by the controller 4 to simulate the pulsation process of a natural heart and provide a stable blood circulation for the fetus 7 .

[0087] Specifically, after receiving the data from the heart acquisition unit 5, the controller 4 performs analysis and processing. According to the analysis results, the controller 4 adjusts the pulsation frequency (i.e., the number of pulsations per minute), the pulsation intensity (i.e., the degree of expansion of the airbag during each pulsation), and the pulsation sequence (i.e., the coordinated actions between the airbag components) of the airbag component. These adjustments are intended to keep the pulsation of the airbag component consistent with the heart activity of the fetus 7, thereby ensuring that the blood can circulate in the artificial uterus 8 in a natural manner.

[0088] Further, in an embodiment provided by the present invention, step 503 includes:

[0089] 5031. In the counterpulsation mode, the controller 4 adjusts the beating frequency, beating intensity and beating sequence of the first airbag assembly 110 according to the data provided by the heart acquisition unit 5.

[0090] For details, see Figure 3 to Figure 4 , Figure 3 The principle of blood entering the blood pump in counterpulsation mode is shown. Figure 4 The principle of blood discharge from the blood pump in the counterpulsation mode is shown. In the counterpulsation mode, the first balloon 111 and the third balloon 113 act as one-way valves. Before the heart ejects blood, the first balloon 111 is deflated and contracted, and at the same time, the third balloon 113 is inflated to block the outlet end 220. When the heart ejects blood, the second balloon 112 is deflated and contracted, low pressure is generated in the pump, and blood is sucked into the pump chamber; when the heart ejects blood, the first balloon 111 is rapidly inflated and expanded, and at the same time, the third balloon 113 is rapidly deflated and contracted, and the second balloon 112 is inflated and expanded, the pressure in the pump chamber increases, and blood is discharged from the pump chamber. The above process is a working cycle of the counterpulsation mode of the sequential balloon pulsation blood pump.

[0091] 5032. In the synchronous mode, the controller 4 adjusts the beating frequency, beating intensity and beating sequence of the first airbag assembly 110 and the second airbag assembly 210 respectively according to the data provided by the heart acquisition unit 5.

[0092] For details, see Figure 6 to Figure 7 , Figure 6 The principle of blood entering the first pump chamber 10 and being discharged from the second pump chamber 20 in synchronous mode is shown. Figure 7The principle of blood entering the first pump chamber 10 and being discharged from the second pump chamber 20 in the synchronous mode is shown. In the synchronous mode, the first balloon 111, the third balloon 113, the fourth balloon 211, and the sixth balloon 213 all act as valves, and the second balloon 112 and the fifth balloon 212 are used as drivers of the blood. In the synchronous mode, the two blood pumps work alternately. The blood pump starts to start. Before the heart ejects blood, the first balloon 111 is rapidly deflated and contracted, while the third balloon 113 is rapidly inflated and expanded to block the outlet end 220. The second balloon 112 is deflated and contracted, and low pressure is generated in the pump chamber, and blood is sucked into the first pump chamber 10. Before entering the second ejection, the fourth balloon 211 is rapidly deflated and contracted, while the sixth balloon 213 is rapidly inflated to block the outlet end 220. The heart ejects blood, the fifth balloon 212 deflates and contracts, and the blood is sucked into the second pump chamber 20; at the same time, the third balloon 113 deflates and contracts, the second balloon 112 inflates and expands, and the blood is discharged from the first pump chamber 10. The blood pump enters a stable working state. In the next cardiac cycle, the third balloon 113 and the fourth balloon 211 are inflated and expanded at the same time, the first balloon 111 and the sixth balloon 213 are deflated and contracted at the same time, the second balloon 112 is deflated and contracted, the fifth balloon 212 is inflated and expanded, and the blood entering the pump is sucked into the first pump chamber 10, and the blood in the second pump chamber 20 is discharged. In the next cardiac cycle, the first balloon 111 and the sixth balloon 213 are inflated and expanded at the same time, the third balloon 113 and the fourth balloon 211 are deflated and contracted at the same time, the fifth balloon 212 is deflated and contracted, the second balloon 112 is inflated and expanded, and the blood entering the pump is sucked into the second pump chamber 20, and the blood in the first pump chamber 10 is discharged.

[0093] The sequential balloon pulsation method for an artificial uterus provided by the present invention can generate pulsating blood flow by setting a first airbag assembly 110 and a second airbag assembly 210, can adapt to the high heart rate of the fetus 7, does not affect the afterload balance of the heart of the fetus 7, and avoids the advantages of umbilical blood vessel catheter spasm.

[0094] It should be understood that the term "and / or" in this article is only a description of the association relationship of associated objects, indicating that there can be three relationships. For example, A and / or B can represent: A exists alone, A and B exist at the same time, and B exists alone. A and B can be singular or plural. In addition, the character " / " in this article generally indicates that the associated objects before and after are in an "or" relationship, but it may also indicate an "and / or" relationship. Please refer to the context for specific understanding.

[0095] In the present invention, "at least one" means one or more, and "plurality" means two or more. "At least one of the following" or similar expressions refers to any combination of these items, including any combination of single items or plural items. For example, at least one of a, b, or c can mean: a, b, c, ab, ac, bc, or abc, where a, b, and c can be single or multiple.

[0096] It should be understood that in various embodiments of the present invention, the size of the serial numbers of the above-mentioned processes does not mean the order of execution. The execution order of each process should be determined by its function and internal logic, and should not constitute any limitation on the implementation process of the embodiments of the present invention.

[0097] The above are only specific embodiments of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art who is familiar with the technical field can easily think of changes or substitutions within the technical scope disclosed by the present invention, which should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims

1. A sequential balloon pulsating blood pump for an artificial uterus, characterized in that: The blood pump comprises: A pump body, the pump body is arranged in the blood flow circuit of the artificial placenta, the pump body comprises a first pump chamber and a second pump chamber; Wherein, a first airbag assembly is arranged in the first pump chamber, and the first airbag assembly includes a first balloon, a second balloon and a third balloon which are arranged in sequence; A second airbag assembly is disposed in the second pump chamber, and the second airbag assembly includes a fourth balloon, a fifth balloon and a sixth balloon which are disposed in sequence; The first pump chamber and the second pump chamber are connected in parallel via a catheter, and the two ends of the catheter are respectively an inlet end and an outlet end of blood, the inlet end is connected to the umbilical artery of the fetus, and the outlet end is connected to the umbilical vein of the fetus via an oxygenator; A controller, the controller being in communication connection with the first airbag assembly and the second airbag assembly respectively; A heart collection unit, which is arranged on the outer surface of the artificial uterus and is in communication connection with the controller; The heart acquisition unit is used to obtain the heart's blood supply time and blood discharge time, and send the blood supply time and blood discharge time to the controller; In the synchronous mode, the controller adjusts the beating frequency, beating intensity and beating sequence of the first airbag assembly and the second airbag assembly respectively according to the data provided by the heart acquisition unit, so that the first airbag assembly and the second airbag assembly work alternately; A pressure sensor is also provided in the pump body, and the pressure sensor is in communication connection with the controller. The pressure sensor is used to obtain pressure data of the blood in the pump body, and the pressure data is sent to the controller.

2. The sequential balloon pulsating blood pump for artificial uterus according to claim 1, characterized in that: The volume of the second balloon after expansion is greater than the volume of the first balloon and the third balloon after expansion.

3. The sequential balloon pulsating blood pump for artificial uterus according to claim 1, characterized in that: The volume of the fifth balloon after expansion is greater than the volume of the fourth balloon and the sixth balloon after expansion.

4. The sequential balloon pulsating blood pump for artificial uterus according to claim 1, characterized in that: The controller includes a regulating module, and the regulating module can adjust the beating frequency and beating intensity of the first airbag assembly and the second airbag assembly according to data provided by the heart acquisition unit.

5. The sequential balloon pulsating blood pump for artificial uterus according to claim 1, characterized in that: Both ends of the catheter are provided with connecting joints for detachably connecting to the fetal umbilical artery and the oxygenator respectively.

6. The sequential balloon pulsating blood pump for artificial uterus according to claim 1, characterized in that: The pump body also includes a temperature regulating device, which is arranged in the pump body and is used to regulate the temperature of the blood in the pump body.

7. A sequential balloon pulsation blood pump system for an artificial uterus, characterized in that: It comprises an artificial uterus, an oxygenator and a sequential balloon pulsating blood pump for an artificial uterus as claimed in any one of claims 1 to 6; The artificial uterus is used to accommodate the fetus, and the two ends of the catheter of the pump body are respectively the inlet end and the outlet end of the blood, and the inlet end is connected to the umbilical artery of the fetus.

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