Insert for overturning device, overturning device and method for overturning medical ampoule

Abstract

An insert (1) for a turnover device (10) for a medical ampoule (2) is provided. The insert (1) comprises: an introduction section (3) having a plurality of introduction openings (4) for receiving in each case one ampoule (2), the introduction openings (4) being arranged in a first arrangement; an output section (5) having a plurality of output openings (6) for outputting in each case one ampoule (2), the output openings (6) being arranged in a second arrangement; and a transition section (7) having a plurality of guide means (8), the transition section (7) being arranged and / or designed in such a way that the ampoule (2) can be guided from the introduction opening (4) to the outlet opening (6) by means of the guide means (8). The inlet opening (4) and the outlet opening (6) are arranged eccentrically with respect to one another. Furthermore, an overturning device and a method for overturning a medical ampoule (2) by means of an insert (1) are provided.

Description

Technical Field

[0001] The invention relates to an insert of a turning device for turning over a medical ampoule, a turning device for turning over a medical ampoule and a method for turning over a medical ampoule. Background Art

[0002] Medical ampoules, for example, cylindrical ampoules or cartridges made of glass, are a kind of widely used primary packaging, in order to transport medicines to be administered intravenously. Such ampoules can be administered by cylindrical ampoule syringes. This is particularly suitable for medicines administered by the patient himself, for example. Such cylindrical ampoule syringes can be assembled with ampoules, so that it is not necessary to remove the medicine from the ampoule (for example, to suck it up into the syringe). This can be done, for example, by introducing the ampoule into the cylindrical ampoule syringe from the rear or by introducing the ampoule from the side. The ampoule is designed accordingly and has a connector for the needle of the cylindrical ampoule syringe on its upper side and a contact surface for the plunger of the cylindrical ampoule syringe on its lower side.

[0003] In principle, for drugs that are administered intravenously, increased control standards are effective. This results in that the drugs contained in the ampoules must be subject to so-called 100% control. In the control, optical control methods are applied, for example, in order to determine whether there are contaminants, particles or other anomalies in the ampoule. Since the ampoules are usually filled from the side where the plunger of the cylindrical ampoule syringe engages at the ampoule, the filled cylindrical ampoule comes out of the filling with the plunger contact element directed upward. In order to be able to perform a safe and satisfactory inspection of the ampoule, the ampoule must be rotated. This is especially based on the following reasons, the syringe contact element of the ampoule covers a part of the ampoule or the drug contained therein, so that it is not feasible to visually inspect all the contents of the ampoule in any orientation of the ampoule.

[0004] Therefore, the ampoules must be turned over before they can be checked. In the prior art, the ampoules are turned over individually or in rows by means of a turning star, a conveyor belt with deflection or by means of a robot. This has the disadvantage that the ampoules must be separated (i.e., with a certain product spacing), whereby the delivery speed of the ampoules is limited. In addition, the known turning facilities are usually very large facilities and thus have a large space requirement. In addition, the ampoules are transported in such a way that contact between the individual ampoules is avoided, since ampoules made of glass are easily damaged in the event of glass-glass contact. Summary of the invention

[0005] It is therefore an object of the present invention to provide a device and a method which, taking into account the above-mentioned boundary conditions, allow for efficient inversion of medical ampoules.

[0006] The above mentioned problem is solved by a device and a method having the features of the independent claims. Preferred embodiments are given in the dependent claims.

[0007] According to one aspect of the present invention, an insert for flipping a medical ampoule is provided. The insert may include an introduction section having a plurality of introduction openings for accommodating each ampoule, wherein the introduction openings may be arranged in a first arrangement. In addition, the insert may include an output section having a plurality of output openings for outputting each ampoule, wherein the output openings may be arranged in a second arrangement. In addition, the insert may include a transition section having a plurality of guide mechanisms, wherein the transition section may be arranged and / or designed such that the ampoule can reach the output opening in a guided manner from the introduction opening through the guide mechanism. The introduction opening and the output opening may be arranged eccentrically relative to each other.

[0008] Compared with the prior art, the present invention provides the following effect, and any arrangement structure of medical ampoules can also be efficiently processed. Here, the arrangement structure can be the distribution of medical ampoules in a plane (for example, along the X direction and the Y direction orthogonal thereto). Under the boundary conditions that direct contact of ampoules should be avoided (keyword: glass-glass contact avoidance) and at the same time a large number of ampoules as much as possible must be arranged in a small space, different arrangement structures appear, and the arrangement structure is not symmetrical when the ampoules are turned over. By this, the array of ampoules provided in the transport container cannot be easily rotated or turned over, because this will cause an arrangement structure that is not suitable for the transport container or other sending methods. In addition, problems will occur in the identification of the ampoules because the position of the ampoules is no longer traceable. However, the present invention can guide the ampoules from the introduction opening to the output opening by an insert, so that the ampoules exist in a desired or predefined arrangement structure after turning over. Thus, a large number of ampoules can be rotated or turned over at the same time, which significantly accelerates the process flow and improves efficiency.

[0009] The medical ampoule can be made of glass and have a holding volume of up to 20 ml inside it. The ampoule can be suitable for being accommodated in a container with a nest. The ampoule can have a contact section for a syringe (syringe contact element) of an ampoule syringe on the first side. At the opposite second end of the ampoule, the ampoule can have a plunger section (plunger contact element), which can work together with the plunger of the ampoule syringe. The ampoule is usually filled with the plunger section oriented upward (in terms of the direction of gravity). The ampoule is usually checked in an inverted or inverted orientation (i.e., in terms of the direction of gravity, with the syringe contact element upward). The ampoule can also be a flangeless syringe (i.e., hanging transport is not feasible).

[0010] The introduction section can define the receiving area of ​​the insert, and the ampoule can be introduced into the insert in the receiving area. The arrangement structure in which the introduction opening is provided can correspond to the holding section for the provided ampoule. The ampoule can be provided in a holding structure (so-called nest). Each ampoule can be held in the holding section. In the top view, the holding structure of the ampoule can form a diamond pattern. Each holding section can be designed in the shape of a diamond. Here, the glass-glass contact between the ampoules respectively held in the holding section can be avoided, and at the same time, as many ampoules as possible are arranged in one face. However, if the arrangement structure of this ampoule is rotated 180° so that the syringe contact element and the plunger contact element exchange their positions, the individual holding sections defined by the single diamond of the arrangement structure do not overlap. Therefore, the arrangement of the introduction opening is different from the arrangement of the output opening. Therefore, the ampoule leaving the output opening can be introduced into the holding structure constructed identically to the holding structure from which the ampoule is taken out. The first arrangement structure can correspond in particular to the arrangement of the ampoule in an unrotated orientation, and the second arrangement structure can correspond to the arrangement of the ampoule in a rotated orientation. The unrotated orientation and the rotated orientation can differ by a rotation angle of 180° here. The output section can be the area where the ampoule of the insert leaves the insert again. The transition section can connect the introduction section and the output section. The transition section can have a guiding mechanism here, which can be implemented in the form of a channel-shaped section or in the form of a grid section, for example. The transition section (for example, the guiding mechanism) can be tilted about the introduction section and / or the output section. The displacement of the ampoule from the first arrangement structure to the second arrangement structure can be ensured thereby. It is important that the guiding mechanism can guide (ie, guide) the ampoule from the introduction opening to the output opening. Guiding is currently understood to be presetting the direction of motion of the ampoule. Here, the direction of motion can be changed in three-dimensional space by the guiding mechanism. In other words, the direction of motion can be designed in three-dimensional space so that all three spatial coordinates of the guided ampoule are changed. In addition, the introduction section and / or the output section can be tilted relative to each other. By this, when the insert is rotated around an axis (e.g., a first axis), the accommodation of the ampoule can be simplified. Here, the ampoule can be introduced or introduced into the insert in advance. The same situation can be similarly applicable to the output section. Here, the introduction opening can be directly connected to the guide mechanism. Downstream of the guide mechanism, the output opening can be directly in contact with the guide mechanism. In other words, the introduction opening, the guide mechanism and the output opening can form a unit designed to transfer the ampoule from the first arrangement structure to the second arrangement structure. Here, the names "introduction section" and "output section" can be related to the orientation of the insert. In other words, the section of the insert in the direction of gravity at the top can be used as the introduction section, and the section of the insert in the direction of gravity at the bottom can be used as the output section. In other words, the name can be changed when the insert is rotated (i.e., when the insert is reoriented).However, the direction of movement of the ampoule through the insert remains the same from the introduction section via the transition section to the output section (starting upstream at the introduction section, via the transition section, until downstream to the output section, i.e., in the main direction of movement). The output opening and the introduction opening can be arranged relative to each other in this way so that the output opening and the introduction opening are arranged eccentrically to each other. Eccentricity is currently understood to mean that the introduction opening and the output opening are arranged so that the introduction opening and the output opening are arranged non-coaxially. In other words, the introduction opening and the output opening can be displaced relative to each other. Therefore, the situation is that during the flipping process of the ampoule, an arrangement structure different from the arrangement structure at the introduction opening can be provided at the output opening. In other words, the first arrangement structure can be different from the second arrangement structure (for example, not overlapping). This provides the advantage that the ampoule provided with an asymmetric arrangement structure can be transferred to an asymmetric arrangement structure even when flipped. Thus, even in the case of such an arrangement structure (the arrangement structure provides the best utilization of the available surface), it can be transferred to such an arrangement structure. This makes it possible to avoid individual turning of the ampoules and to turn over a large number of ampoules simultaneously. This avoids the need to separate the ampoules to provide a specific product spacing and allows high delivery speeds (e.g. 1000 ampoules per minute). The transition section can be movable so that the association of the input opening and the output opening can be changed. By this means, the insert can be adapted to different initial situations (e.g. to different arrangements, e.g. in the nest). The transition section can be variable, for example, relative to the input opening and / or the output opening. For example, the transition section can be deformable and / or movable. It is also conceivable that the introduction section and / or the output section are also deformable and / or movable. By this means, the insert can be better adapted to different initial situations.

[0011] Preferably, the first and second arrangements differ in particular in their spatial arrangement. In other words, the coordinates in the space of the introduction opening and the outlet opening associated with the introduction opening via the transition section (i.e., spatial coordinates) can deviate from each other. More precisely, at least two spatial coordinates can be different. This makes it possible to provide any second arrangement (i.e., a structure in which the ampoule is delivered in an inverted manner) for a given first arrangement (i.e., a structure in which the ampoule is delivered).

[0012] Preferably, the introduction opening and the output opening are identically configured in terms of the geometrical design of the corresponding openings. In other words, the introduction opening and the output opening associated with the introduction opening in a conveying manner can have the same geometrical cross-section. For example, not only the introduction opening but also the output opening can have a circular cross-section. Alternatively, not only the introduction opening but also the output opening can have a rectangular cross-section. It can thereby be achieved that both geometrical designs can be used not only as introduction openings but also as output openings. By reorienting the insert, not only the geometrical structure arranged above can be used as introduction opening, but also the geometrical structure arranged below (observed in the direction of gravity, respectively) can be used as output opening. As a result, seamless operation of the insert can be achieved without the need to rotate the insert back to a specific initial position each time.

[0013] Preferably, the introduction opening and the output opening of the top view of the insert are arranged offset from each other. It can thus be achieved that the output opening is arranged non-overlappingly with the output opening in a top view of the insert. The top view of the insert can be defined along the main transport direction of the ampoule from the introduction opening to the output opening. The main transport direction can extend along the direction of gravity. However, in some embodiments, the main transport direction is inclined relative to the direction of gravity. Thereby, an offset arrangement of the ampoule at the output opening with respect to the original arrangement at the introduction opening can be achieved.

[0014] Preferably, the introduction section, the outlet section and the transition section are integrally formed. In other words, the insert can be formed as a one-piece (ie, integrated) component. This simplifies the manufacture of the insert and prevents errors in possible assembly of a multi-piece system.

[0015] Preferably, the ampoule is guided along the guide path by each guide mechanism, wherein the guide mechanism is designed so that the guide path is pivotable. Thus, the ampoule delivered to the insert at the introduction section can be transferred to any second arrangement by the guide mechanism. In addition, the spatial coordinates can thus be changed from the initial position in which the ampoule is delivered to the introduction section to the new position in which the ampoule is delivered from the insert by the delivery section. Preferably, all three spatial coordinates can be changed.

[0016] Preferably, the introduction opening, the outlet opening and / or the guide mechanism have a substantially circular cross section. In other words, the cross section can be a region defining a passage path for the ampoule from the introduction opening to its associated outlet opening. The advantage obtained by the same cross section is that the manufacturing can be simplified (for example, in terms of the shape design in the injection molded part). Alternatively, it is preferred that at least the introduction opening and the outlet opening have substantially the same cross section. For example, the guide mechanism can also be a structural element that contacts the ampoule in a point manner or a segment manner so as to deflect the ampoule in the correct direction. It is conceivable that the guide mechanism is also designed as a type of grid frame. By arranging the same cross section in the introduction opening and the outlet opening, it can be advantageously achieved that the introduction opening can be exchanged with the outlet opening regardless of the orientation of the insert. Basically in the current case, it can be meant that a strictly circular shape is not a prerequisite here, but also includes a shape that deviates from the ideal circular shape by 5%, for example. Production tolerances can be taken into account by this. Preferably, the introduction opening, the outlet opening and / or the guide mechanism have a substantially U-shaped cross section. This provides the following advantage, the insert can be manufactured layer by layer. Each layer can have at least one inlet opening, at least one outlet opening and at least one guide. The guide can be open to one side of the layer. Thus, each guide of a layer (and, if necessary, each introduction section and / or outlet section) can be formed, for example, by means of a spherical milling cutter. The individual layers can then be joined together. Thus, the guide can be closed by adjacent layers. In other words, each layer can be implemented as a milled disk. Here, for manufacturing reasons (spherical milling cutter from the side), the cross section can correspond to a "U".

[0017] Preferably, the insert is designed such that the ampoule can be gravity-driven from the introduction section to the outlet section. In other words, the insert does not have to include an actuator or a drive device (e.g. a suction device, etc.) responsible for bringing the ampoule from the introduction section to the outlet section. For example, a gravity-driven movement of the ampoule can be achieved. This can be achieved, for example, by reorienting and / or shifting the insert. Thus, for example, the ampoule can be arranged at at least one introduction opening, which can then be gravity-driven by rotating the insert by approximately 180° and transferred to the outlet section via the transition section. Since a separate actuator or the like does not have to be provided in order to cause the movement of the ampoule, the system can be designed more simply overall.

[0018] Preferably, each guide mechanism comprises at least one braking section, which is designed to reduce the movement speed of the ampoule when it is guided from the introduction section to the output section. It can be ensured that even sensitive ampoules that are turned over by the insert will not be damaged. The maximum permissible movement speed of the ampoule can be limited by the braking section. The braking section can be, for example, an elastic protruding element that extends into the movement path defined by the guide mechanism. When the ampoule passes through the braking section, the ampoule can contact the braking section and the braking section can brake the ampoule (i.e., reduce the speed). It is also conceivable that the braking section is a section with increased friction between the ampoule and the guide mechanism, so that the movement speed of the ampoule can be reduced. For example, the guide mechanism can have a section with increased friction, for example, a soft material that is arranged in sections to reduce the movement speed of the ampoule when in contact with the ampoule. This is also advantageous in the following system, in which the ampoule is gravity-driven and transported from the introduction section to the output section. Therefore, the maximum movement speed of the ampoule can be limited here, thereby avoiding damage to the ampoule.

[0019] Preferably, the insert is designed as a molded part. A molded part can be understood as a part which is molded for a specific application purpose in a production tool manufactured specifically for this purpose. Furthermore, providing the insert as a molded part offers the advantage that the molded part can even be easily replaced by the user. Thus, different molded parts can be provided for ampoules of different sizes. Furthermore, different molded parts can be provided for different arrangements, for example the first arrangement and / or the second arrangement. This can further simplify the use of the insert.

[0020] Preferably, the introduction opening and the outlet opening are directly adjacent to the guide means. In other words, no further elements are arranged between the introduction opening and the outlet opening as guide means designed to guide (i.e. direct) the ampoule. This allows compact dimensions of the insert to be achieved. Furthermore, this allows the path that the ampoule has to travel from the introduction section to the outlet section (i.e. from the introduction opening to the outlet opening) to be minimized, which reduces the risk of damage to the ampoule.

[0021] Preferably, the first arrangement and the second arrangement are defined by the arrangement of the introduction opening and the output opening in a two-dimensional plane. In other words, the arrangement can be characterized by how the openings of the introduction section and the output section are arranged in a two-dimensional plane. Therefore, the arrangement can also be defined by an arrangement in which the ampoule is provided to the insert. For example, the ampoule can be arranged in a specific manner and method in a container (for example, arranged in a nest accommodated in a tub). The arrangement of the ampoule can correspond to the arrangement. The first arrangement can describe an arrangement in which the ampoule is delivered to the insert or exists before the ampoule is processed by the insert. The second arrangement can describe how the turned ampoule is output from the insert. Therefore, the arrangement of the introduction opening, that is, how the introduction opening is arranged, is defined by how the ampoule is provided to the insert. This can be defined, for example, by how the ampoule is delivered by the filler (ie, the person who fills the ampoule with the drug). In contrast, the second arrangement can be defined by the insert (i.e., by the arrangement of the output opening). In other words, any second arrangement can be provided by the insert. In one embodiment of the invention, it is advantageous that the first arrangement defined by the filler is preset by a specific transport container (e.g., a nest in a basin). According to the above-described embodiment, the insert can design the second arrangement (i.e., the arrangement output from the insert) so that the inverted ampoule can be inserted back into the transport container. This provides the advantage that no separate or differently designed transport container is required, but that the transport container originally provided by the filler can also continue to be used for the inverted ampoule. This also provides the advantage that the identification method and tracking method at the beginning of the filler can also continue to be used in the further processing process (preferably using the determination method described below).

[0022] Preferably, the insert comprises polyoxymethylene, polyamide, polytetrafluoroethylene and / or polyethylene terephthalate. Polyoxymethylene (POM) is characterized by high strength, hardness and rigidity in a wide temperature range. As a result, it is particularly durable and has a high life expectancy. Polyamide also has high strength, rigidity and toughness as well as very good chemical resistance and processability. Here, for example, other characteristics can be defined via the amide group of the polyamide. This depends on the specific application of the insert, because chemical cleaning must usually be performed here due to hygiene requirements. For example, cleaning is carried out with hydrogen peroxide in some areas, which attacks many other materials. Therefore, it is advantageous to use high-quality plastics in the current insert in order to ensure durability. In other fields of application, this is unnecessary and presents unnecessary costs. It is also conceivable to use polytetrafluoroethylene (PTFE). PTFE is also known, for example, under the trademark Teflon. It is particularly advantageous here that particularly low friction values ​​can be achieved, so that ampoules can be handled without problems through the insert. In addition, PTFE reacts very slowly, so even corrosive acids do not attack PTFE. It is also conceivable that polyethylene terephthalate (PET) can be used. PET also has a high resistance to chemical agents and is therefore widely used in medical technology and the food industry. In addition, PET has a high mechanical resistance, which also results in an increased durability of the insert.

[0023] Preferably, the ampoule has a maximum content of 20 ml. Thus, the ampoule can be used during ampoule injection molding.

[0024] Preferably, the medical ampoule is arranged in the nest. In other words, the ampoule provided to the insert for flipping can be provided in a manner arranged in a holder or a holding structure (i.e., a nest). In principle, the ampoule can stand on its bottom due to gravity. In other words, the ampoule can stand on the bottom in the basin and be held, for example, by a grid-like structure (nest). In contrast, for example, a syringe is transported suspended. The nest can hold the ampoule. Therefore, the nest can be provided for holding the ampoule in a specific arrangement, in particular spaced apart from each other. Here, the weight can be held by the nest and / or by other elements such as a basin (further details of this are provided below). For example, the nest can be responsible for the first arrangement structure and / or the second arrangement structure.

[0025] Preferably, the medical ampoules are each held in the nest in the shoulder region of the respective ampoule. The shoulder region of the ampoule can be a particularly resistant region, so that the ampoule can be best held there without the risk of damage. In addition, the nest can be designed to lift the ampoule out of the basin. For this purpose, the nest can be designed to hold the ampoule in an area that is arranged adjacent to a relatively thicker area, such as a cover area or a syringe contact element. The ampoule can thus be lifted from the basin through the nest. Preferably, the nest can be designed so that the ampoule can be held only in one direction, so that the ampoule can be poured out of the nest.

[0026] Preferably, the nest is arranged in the basin. The basin can be a shell-shaped structure, in which the nest is arranged together with the ampoule. The nest can be designed so that it fits into the basin with an exact fit. Therefore, a relative movement of the nest with respect to the basin can be avoided.

[0027] Preferably, the basin has an identification element. For example, the identification element can indicate which ampoule is arranged in the basin and / or which position in the nest arranged therein. In addition, other information, such as the type of content material and / or processor-oriented prerequisites or requirements, can be retrieved via the identification element.

[0028] According to another aspect of the present invention, a flipping device for flipping a medical ampoule is provided, the flipping device comprising an insert according to any one of the above embodiments. The flipping device may include a holding device for holding the insert. The holding device may be designed to move the insert along a first direction. The holding device may be designed to rotate the insert around a first axis. The flipping device may present an automated application of the insert according to any one of the above embodiments. In other words, the insert may be used manually or in other processing or machining of the ampoule. The flipping device described now may be an individualized processing device, which is designed to flip the ampoule. Preferably, the flipping device is at least partially automated so that at least some of the processing steps can be run fully automatically. Thus, manual work can be reduced and efficiency can be improved. The holding device may be a structured device that can movably hold the insert. Preferably, the holding device is a double-arm device that rotatably supports the insert at the outer ends of the respective arms. The two arms may be connected to a basic arm. The basic arm may be movably arranged at a stand or a support. This allows the holding device to move the insert in a first direction. The first direction can extend in the direction of gravity. By rotatably mounting the insert on the two arms of the holding device, the holding device can rotate the insert about a first axis. Preferably, the insert is held on the holding device in such a way that the first axis extends through the center of gravity of the insert. This allows a particularly uniform (e.g. smooth) rotational movement about the first axis.

[0029] Preferably, the first direction and the first axis are orthogonal to one another. Thus, by a movement in the first direction, the ampoule can be accommodated and subsequently or at least partially simultaneously re-supported by a rotation of the insert about the first axis. In other words, by a movement in the first direction, the nest can be lifted out of the basin and as soon as the nest is lifted out of the basin, a gravity-driven movement of the ampoule is initiated by a rotational movement in order to cause a movement of the ampoule from the introduction opening to the respectively associated outlet opening (e.g. in the main movement direction).

[0030] Preferably, the first direction extends in the direction of gravity. This offers the advantage that the ampoule remains in its original position due to gravity as long as the insert moves only in the first direction. The movement of the ampoule is only caused by the insert by the rotation about the first axis of rotation.

[0031] Preferably, the flip device includes an actuator, wherein the actuator can be designed to perform movement in a first direction and / or rotation around a first axis. In other words, only a single actuator can be provided, which is responsible for movement in the first direction and rotation around the first axis. This can be caused, for example, via mechanical manipulation of the holding device. By providing only a single actuator, control electronics and control costs can be reduced. In addition, a synchronous motion process can be achieved by a single actuator (i.e., by mechanical control of two movements, i.e., translational movement in the first direction and rotational movement around the first axis), so that the movement is performed in a desired order and at a desired moment. Thus, the system can be designed more simply and more reliably at the same time. Preferably, the flip device has a control unit, which can be designed to obtain the original position of the medical ampoule and determine the new position of the medical ampoule after leaving the outlet opening. This is particularly advantageous if the ampoule is delivered to the flip device in a specific arrangement. Therefore, for example, it is conceivable that a basin with a nest filled with ampoules is provided by a filler, wherein which ampoule is placed at which position is accurately grasped at the basin by an identification mechanism or other information transmission. This is very important, for example, in a tracking system. If the ampoule is now turned over by a turning device, it must also always be clear which ampoule is located at which position in the turned state. This depends on how the transition section transfers the ampoule from the introduction opening to the output opening. Therefore, the control unit can determine which original position of the ampoule corresponds to which current position of the ampoule after turning over based on the type of insert arranged in the turning device. In other words, the control device can determine, due to mathematical considerations, which ampoule is arranged where after the turning process by the turning device. This can then be output by the control unit again and, for example, transmitted to a database. Therefore, after the ampoule is successfully turned over by the turning device, it can also be clearly determined which ampoule is arranged where in the nest in the basin.

[0032] Preferably, the turning device comprises a holding device, which can be designed to hold a first nest with a plurality of ampoule holding positions in such a way that each ampoule holding position is opposite one of the introduction openings. As described above, the first arrangement is determined by how the ampoule is provided to the insert or the turning device. The insert is adapted accordingly. For further automation, the turning device can now have a holding device, which can grip the nest so that the ampoule present in the nest is just opposite the introduction opening of the insert. This provides the advantage that when the insert is rotated about the first axis, the ampoule slides out of the nest and slides into the insert.

[0033] Preferably, the holding device is designed to hold the second nest with multiple ampoule holding positions so that each ampoule holding position is opposite to an output opening. In other words, the flipping device can hold two nests by the holding device. If the ampoule should be introduced back into the nest or basin (i.e., in the flipped state), this is particularly advantageous. According to one embodiment of the present invention, the ampoule is transported back to a nest with the same structure as the nest from which the ampoule is taken out, for example, and is transported back to the same basin as the basin from which the ampoule is taken out. In other words, only the orientation of the ampoule is changed by the flipping device, but the transport mechanism of the ampoule remains the same. Thus, the flipping device can be seamlessly connected to the existing process without having to structurally change the process. According to this embodiment, the flipping device can have a first nest at its insert at the side of the introduction opening and a second nest at the side of the output opening. The ampoule holding position in the corresponding nest can be opposite to the corresponding introduction opening and output opening. It can thus be ensured that the ampoule can be transported from the introduction opening through the transition section to the associated outlet opening (for example driven by gravity). The holding device can be designed to hold the first nest and the second nest on the insert.

[0034] Preferably, the holding device is a suction device. The suction device can have at least one suction cup, which can suck the nest so that the nest can be lifted out of the basin. The suction device can also be called a suction gripping device. For this purpose, the holding device can be designed to apply a suction force to the shoulder of the nest in order to hold the nest. Alternatively, a mechanical gripping device can also be provided, which can grip and hold the nest.

[0035] Preferably, the turning device comprises at least one positioning aid, which can be designed to ensure a predetermined position of the nest when the nest contacts the turning device. The positioning aid can thus help to associate the ampoule holding position in the nest with the corresponding opening in the insert. This can always ensure an optimal orientation of the nest relative to the insert. This can provide a problem-free operation of the turning device.

[0036] Preferably, the positioning aid comprises a projection which projects from the turning device and can be designed to cooperate with the nest. Thus, the positioning aid can comprise at least one projection which projects from the insert. The projection can, for example, have a shape which tapers towards its outer end and cooperates with the opening at the nest. For example, if the nest is close to the insert, the projection can be introduced into the recess of the nest and the nest and / or the introduction device can be guided by the shape of the projection so that an optimal position between the nest and the insert is achieved. This can further increase process reliability.

[0037] Preferably, the turning device has at least one distance element, which can be designed to ensure a predetermined spacing of the nest relative to the turning device when the nest contacts the turning device. The distance element can be used to limit the spacing between the insert and the nest to a minimum. This can, for example, avoid damage caused by direct contact with the ampoule and the insert contained in the nest. For example, ampoules of different heights can be processed by the turning device without problems. In addition, a gripping device that can be controlled less accurately can also be used, which can grip or hold the nest so that it can be guided to the insert until the distance element contacts the nest element. The distance element can, for example, be a protrusion that can interact with the shoulder of the nest. This can improve process reliability and avoid damage to the ampoule.

[0038] It is also conceivable that the control unit can control the rotation around the first axis so that the rotation can be performed adaptively or variably rather than continuously. This provides the advantage that the ampoule can be prevented from falling freely from the first nest toward the second nest (i.e., from the introduction opening to the associated output opening). By the rotational movement around the first axis, the static friction between the ampoule and the nest or the insert is overcome and converted into sliding friction. However, because the sliding friction is less than the static friction, the ampoule is suddenly accelerated due to gravity. For this reason, the control unit can be designed so that the insert is rotated around the first axis until the static friction is overcome. Subsequently, the rotational movement can be stopped so as not to accelerate the ampoule further. The stop can be performed after a rotation angle of at least 90°. Preferably, the stop is performed after a rotation angle in the range of 100° to 135°. This is proven to be advantageous when processing glass ampoules because static friction is overcome within this range. According to a particularly preferred embodiment, the control unit can even rotate a short section in the opposite direction after overcoming the static friction so as not to accelerate the ampoule so strongly. For example, the insert can be rotated back by approximately 5°. This makes it possible to handle particularly sensitive ampoules without problems by turning the device over. Once the ampoule has passed through the insert and is received in the second nest, the control unit can then perform the remaining rotation to complete the 180° rotation.

[0039] Preferably, the flipping device comprises a sensor which can determine the position of the ampoule. For example, the sensor can be a center of gravity sensor which can determine the center of gravity of the insert together with the first nest and the second nest. Since one nest is filled with an ampoule and the other nest is empty, the center of gravity is not on the first axis. Depending on where the center of gravity is located, the control unit can determine at which moment of the rotational movement around the first axis the center of gravity is located. Thereby, the control unit can infer the current position of the ampoule and can detect the start of the movement of the ampoule (i.e., overcoming static friction). The control unit can then adjust the rotational movement around the first axis. Thus, for example, the rotational movement can also continue more slowly than at the beginning in order to achieve the desired movement speed of the ampoule. This can occur automatically based on pre-stored information. Thus, for example, no individualized adjustment is required when processing ampoules with a different filling amount. Thus, further improvement of operational safety and reduction of the damage rate of the ampoule can be achieved.

[0040] According to another aspect of the present invention, a method for turning over a medical ampoule by means of an insert is provided. The method comprises providing a plurality of medical ampoules in a first arrangement, receiving the ampoules in respective introduction openings of the insert, guiding the ampoules from the receiving openings to the output openings of the insert by means of a guide mechanism of the insert, and outputting the ampoules from the output openings in a second arrangement, wherein the first arrangement is different from the second arrangement.

[0041] Preferably, the ampoule is provided in a first nest, wherein the method comprises holding the first nest at the insert. The holding can be achieved, for example, by a suction gripping device. Preferably, the ampoule is output into a second nest, wherein the second nest is held at the insert. Here, the second nest can have the same geometric dimensions as the first nest. Therefore, the first nest can be held at the insert so that the ampoule can be introduced into the introduction opening. Therefore, the second nest can be held at the insert so that the ampoule output from the insert can be delivered to the second insert at the output opening. Preferably, the method comprises moving the insert so that the ampoule is guided from the introduction opening to the output opening by a guide mechanism driven by gravity. Preferably, the movement comprises rotating the insert about a first axis. Preferably, the first nest is provided in a basin, and wherein the first nest is lifted out of the basin along a first direction. Preferably, the second nest with the ampoule is introduced into the basin from which the first nest has been removed. Thus, the ampoule can be delivered to the same pot from which the ampoule was taken. In other words, the identification means provided at the pot remains valid for the ampoule even after the turning process. Preferably, the method comprises an identification of the pot in which the ampoule is provided.

[0042] Preferably, the method further comprises determining a new position of the ampoule in the second nest. The method may then output information about the new position of the ampoule in the basin, and the further method is based on said information. After the ampoule has been turned over, the ampoule may be transported for inspection. Preferably, 120 ampoules may be provided in each basin. In other words, 120 ampoules may be turned over at a time. Preferably, the average spacing between the ampoules in a nest is approximately 11.6 mm.

[0043] According to another aspect of the present invention, the use of the insert according to the above embodiment for turning over a medical ampoule is provided. In particular, the use of the insert in a turning device among the above turning devices is provided. This can provide an advantageous process flow with improved efficiency.

[0044] The various features of the above-mentioned embodiments can be combined with more than 20,000 embodiments or other features to form new embodiments. The design solutions and advantages mentioned in conjunction with the features or embodiments are then also similarly applicable to the new embodiments. The advantages and design solutions mentioned in conjunction with the method are also similarly applicable to the device, and vice versa. BRIEF DESCRIPTION OF THE DRAWINGS

[0045] Preferred embodiments are described in detail below with reference to the accompanying drawings.

[0046] Figure 1 is a schematic cross-sectional view of an insert according to one embodiment of the present invention.

[0047] Figure 2is a schematic and perspective view of a basin, nest, and a plurality of ampoules as used in one embodiment of the present invention.

[0048] Figure 3 is a schematic view of a nest filled with ampoules.

[0049] Figure 4 is a schematic view of a nest filled with ampoules contained in a basin as provided in an inversion device according to one embodiment of the present invention.

[0050] Figure 5 is a schematic and perspective view of a flip device according to one embodiment of the present invention.

[0051] Figure 6 is a schematic side view of a flipping device according to one embodiment of the present invention.

[0052] Figure 7 is a schematic and perspective view of an insert according to an embodiment of the invention as may be used in a turning device according to an embodiment of the invention.

[0053] Figure 8 is a schematic and perspective view of a flip device according to one embodiment of the present invention.

[0054] Fig. 9 are a number of schematic and perspective views of a flip device in operation according to one embodiment of the present invention. DETAILED DESCRIPTION

[0055] Figure 1 1 is a schematic cross-sectional view of an insert 1 according to one embodiment of the present invention. The insert 1 has an introduction section 3, a transition section 7 and an output section 5. The introduction section 3 has a plurality of introduction openings 4 (in Figure 1 In the figure, only the introduction opening is indicated by the reference numeral 4). The insert 1 is designed to transfer medical ampoules 2. In other words, the insert can transport the ampoule 2 and output it to another spatial position. To this end, the ampoule 2 can be accommodated at the introduction section 3 through the introduction opening 4. Here, each introduction opening 4 can only accommodate one ampoule 2. Subsequently (i.e. downstream), the ampoule 2 can enter the delivery section 7. The delivery section 7 has a plurality of guide mechanisms 8, which are designed to guide the ampoule 2. In the present embodiment, the guidance of the ampoule 2 consists in outputting the ampoule 2 again at another position. The output of the ampoule 2 is carried out via the output section 5, which has a plurality of output openings 6. The ampoule 2 can be provided, for example, in the first nest 11 ( Figure 1). The ampoule 2 can then leave the first nest 11, enter the insert 1 via the introduction opening 4, be guided through the transition section 7 or the guide mechanism 8 provided therein, and finally leave the insert 1 via the output opening 6. A second nest 12 can be arranged adjacent to the output opening 6, into which the ampoule 2 can be introduced after leaving the insert 1. It is not necessary to provide the second nest 12, but it is also possible to provide additional equipment for receiving ampoules. It is conceivable here, for example, that the ampoule 2 is further processed directly in a process. However, according to a preferred embodiment, the ampoule 2 is introduced into the second nest 12 after leaving the output opening 6, wherein the second nest 12 is designed identically to the first nest 11. When the ampoule 2 passes through the insert 1, the ampoule 2 is conveyed along the main conveying direction H (see Figure 1 In other words, the ampoule 2 is displaced in all three spatial directions (X direction, Y direction and Z direction) by the insert 1 .

[0056] Figure 2 1 is a schematic and stereoscopic view of nests 11, 12 with a plurality of ampoules 2 accommodated therein. The nests are arranged in a basin 13. The basin 13 with the nests is usually used to transport the ampoules 2 filled with the drug from one filler to another process unit. The nests 11, 12 and the basin 13 are usually steam sterilized so that even in the aseptic area, a worry-free handling can be achieved. The nests 11, 12 are in order to avoid direct contact between the ampoules 2. Therefore, glass-glass contact can be avoided, thereby reducing damage to the ampoules 2. In order to place the maximum possible number of ampoules in one nest 11, 12, the ampoules are arranged in the nests 11, 12 in a first arrangement. When the ampoules 2 come from the filler, the ampoules are oriented with the bottom side upwards, because the filler fills the ampoules provided for use in the ampoule syringe from below. If the ampoule 2 is to be visually inspected later, the ampoule needs to be turned over. This is because, in the upper region of the ampoule (i.e. the region where the syringe is placed and the medicine is removed from the ampoule), part of the ampoule or its contents are covered. Therefore, the ampoule must be turned over or inverted. Figure 2 In the case of the arrangement, the ampoule is already correctly oriented for inspection.

[0057] Figure 3 The three-dimensional and schematic view of the nests 11, 12 accommodated in the basin 13 is a view from obliquely above. It can be seen here that the ampoules 2 are each accommodated in a rhombus-shaped section (ampoule holding position). If, for example, the arrangement is reversed (i.e. pivoted 180°) and placed on an empty nest with the same configuration, the ampoule 2 cannot fall into the rhombus-shaped receiving position of the new nest, because the receiving positions are not superimposed on each other. In order to solve this problem, the insert 1 according to the invention is used to transfer the ampoule 2 to another arrangement during the turning of the ampoule 2.

[0058] Figure 4 is a schematic and perspective view of a basin 13 having nests 11, 12 in which a plurality of ampoules 2 are accommodated. In this case, the ampoules 2 are in an orientation that requires turning over the ampoules 2 for subsequent inspection. In other words, the ampoules 2 are oriented with the bottom facing upwards. Thus, Figure 4 The situation shown in FIG. 1 is the initial situation before the ampoule 2 is turned over.

[0059] Figure 5 FIG. 1 is a schematic and perspective view of a flipping device 10 according to an embodiment of the present invention. The flipping device 10 is used to flip a medical ampoule 2 from Figure 4 The initial situation shown in the figure is transferred to Figure 3 To this end, Figure 1The insert 1 shown in FIG. 1 is arranged in a flipping device 10. In addition, the flipping device 10 has a holding device 13 that can hold the insert 1. Here, the flipping device can rotate the insert 1 around the first axis A1. To this end, the flipping device 10 has two actuators 14. In addition, the holding device 13 can move (i.e., translate) along a first direction R1. In the present embodiment, the first direction R1 extends along the direction of gravity (i.e., from bottom to top). The flipping device 10 accommodates a first nest 11 and a second nest 12 at two opposite sides of the insert 1. The first nest 11 has an ampoule 2. The second nest 12 is empty and is designed in the same manner as the first nest 11. By making the first nest 11 and the second nest 12 opposite each other, the corresponding ampoule holding positions in the corresponding nests 11 and 12 are not opposite each other. Only the insert 1 connects the ampoule holding position in the first nest 11 with the ampoule holding position in the second nest 12 via the introduction section 3, the transition section 7 and the output section 5. By rotating the flipping device 10 about the first axis A1, the main direction of movement H of the ampoule can be selected arbitrarily by the insert. In the present embodiment, the ampoule 2 that is incorrectly arranged in the first nest 11 is transported into the second nest 12 by the rotation about the first axis A1 through the insert 1. Then, the ampoule 2 is placed in the second nest 12 with the upper side facing upward. Therefore, all ampoules 2 arranged in the first nest 11 can be flipped at once. Thereby, it is not necessary to process individual ampoules or individual ampoule rows individually, but the entire ampoule matrix can be directly transferred from the first nest 11 to the second nest 12 in order to change the orientation of the ampoules. The flipping device 10 has a holding device 13, which can hold the insert 11 and move it. For this purpose, the holding device 13 can have a first arm 17 and a second arm 18. Overall, the holding device 13 can have a U-shaped cross section, wherein the first arm 17 and the second arm 18 protrude from the connecting arm 20. The connecting arm 20 can be movably fixed to the stand or support 15. More specifically, the connecting arm 20 can be guided in a track provided at the stand 15. As a result, a first direction of movement R1 can be defined. In a preferred embodiment, the turning device 10 can be automatically moved along the first direction R1. This can be achieved, for example, by a threaded rod or by a gear, which can mesh with a rack. As a result, the turning device can lift the first nest 11 out of the basin 13. Here, the turning device 10 only has to lift the first nest 11 out of the basin 13 to such an extent that the first nest can be rotated around the first axis A1. The second nest 13 can be arranged at the side of the insert 1 facing the outlet opening 6 from the beginning.

[0060] Figure 6 is a schematic side view of a flip device 10 according to one embodiment of the present invention. Figure 5 The embodiment shown in FIG. Figure 6 and Figure 5 As can be seen in the figure, a gripping device 16 is provided at the flipping device 10. In the present embodiment, the gripping device 16 is designed as a suction gripper. In particular, in the present embodiment, a plurality of suction grippers 16 are arranged, which are designed to lift and hold the nests 11, 12 out of the basin 13. This ensures that the nests 11, 12 do not fall off the insert 1 during the flipping process. In addition, the flipping device of the present embodiment includes a positioning aid 19. In the present embodiment, the positioning aid 19 is designed as a protrusion protruding from the insert 1. The positioning aid 19 has a shape that tapers toward the outer end. Therefore, the positioning aid 19 can work together with the openings in the nests 11, 12 to ensure the correct position of the nests relative to the insert 1. Therefore, it can be ensured that not only the introduction opening 4 but also the output opening 6 are opposite to the ampoule holding positions in the first nest 11 and the second nest 12, respectively. In addition, the turning device has a plurality of distance elements 20, which are designed to maintain a distance between the nests 11, 12 gripped by the turning device 10 and the insert 1. This prevents the ampoules 2 accommodated in the nests 11, 12 from being damaged due to direct contact with the insert or other objects. The distance elements can be, for example, cylindrical rods protruding from the turning device. The distance elements can directly contact the nests 11, 12.

[0061] Figure 7 is a three-dimensional view of the turning device 10, on which no nests 11, 12 are arranged. The upper side of the insert 1 can be seen, which has an introduction opening 4 arranged thereon. In addition, the suction grippers 16 can be seen. In the present embodiment, eight suction grippers 16 are provided, of which four are arranged on each side. The positioning aid 19 is arranged centrally on each side of the insert 1. In the present embodiment, the introduction opening 4 has a rectangular cross section. Subsequently, the guide mechanism 8 is also provided with a rectangular cross section. Subsequently, the output opening 6 is also provided with an angular cross section. In another embodiment not shown, the cross sections of the introduction opening 4, the guide mechanism 8 and the output opening 6 are provided with circular cross sections.

[0062] Figure 81 is a perspective view of the flipping device immediately before picking up the first nest 11. It can be seen that the empty second nest 12 is arranged at one side of the insert 1. A basin 13 with nests 11 and filled with ampoules 2 is provided below the flipping device 10. Subsequently, the flipping device 10 is moved toward the first nest 11 along the first direction R1. When in contact with the first nest 11, the positioning aid fine-tunes the position of the first nest 11 until the prepared suction gripper 16 contacts the first nest. Then, the first nest 11 is sucked and lifted out of the basin 13 in the first direction R1. Above the basin 13, the insert 1 rotates around the first axis A1 so that the ampoule 2 is transferred from the first nest 11 through the insert 1 to the second nest 12. The rotation speed around the first axis is controlled by the control unit. In a preferred embodiment, the control unit (not shown in the figure) can control the rotation so that after overcoming the static friction of the ampoule 2 in the first nest 11, the insert 1 stops or rotates in the opposite direction. As a result, an excessive acceleration of the ampoule 2 in the main conveying direction H can be avoided. If the ampoule 2 then reaches the second nest 12, the rotation can be completed so that the insert is rotated once by 180°. The second nest 12 can then be introduced into the original basin 13 again by the movement of the flipping device 10 in the first direction. The identification arranged at the basin 13 can thus be retained, because the same ampoule 2 is arranged again in the same basin 13 (just with a different nest). In addition, the control unit can be designed to compare the new position of the ampoule 2 with the data arranged on the basin 13, so that which ampoule 2 is arranged at which position in the second nest 12 is saved. In other words, the position of the ampoule 2 can be converted by the control unit as it was in the first nest 11 in the past, so that it is known where the same ampoule is arranged in the second nest 12. This makes it possible to trace the ampoule back through the entire process of handling the ampoule 2.

[0063] Fig. 9 Ten individual images a) to j) are shown which illustrate the working step of turning over a medical ampoule. Fig. 9 a) shows that the medical ampoules 2 are provided in the nests 11 arranged in the basin 13. Fig. 9 In b), the turning device 10 is lowered onto the first nest 11 and gripped by the suction gripper. The turning device already has a second nest 12 on the opposite side of the insert 1. Fig. 9 In c), the nest 11 is lifted out of the basin 13 in a first direction of movement R1. Fig. 9 In d), a rotation about the first rotation axis A1 is started in order to transfer the ampoule 2 from the first nest 11 to the second nest 12. Fig. 9 e), a 90° rotation, wherein no ampoule 2 has yet been transferred from the first nest 11 to the second nest 12. Fig. 9In f), the rotation around the first axis A1 is continued. Fig. 9 In G, the rotation about the first axis A1 is completed, whereby the insert 1 together with the first nest 11 is rotated through 180°. Fig. 9 In h), the closure is opened, thereby freeing a passage for the ampoule 2 to pass through the insert 1. The ampoule passes from the first cavity 11 through the insert 1 into the second cavity 12 driven by gravity. Fig. 9 In i), the turning device 10 is moved downwards again in the first direction R1 in order to insert the second nest 12 together with the now turned-over ampoule 2 into the basin 13 again. Fig. 9 In j), the turning device 10 moves upwards again in the first direction R1 in order to release the pot 13 for further processing.

[0064] exist Fig. 9 The turning device 10 shown in FIG. 1 differs from the turning device 10 shown previously in that the passage through the insert 1 can be released and closed by a blocking element (not shown in the figure). In other words, it is possible to actively control when the ampoule 2 can be transported through the insert 1. In the above-described embodiment, the transport of the ampoule 2 begins when the static friction between the ampoule and the nest is overcome. In the present embodiment, this is actively controlled by the blocking element.

[0065] In another embodiment (not shown), it is conceivable that a plurality of turning devices 10 are arranged along the conveying line so that a plurality of nests can be turned in parallel. This can further increase the output.

[0066] Reference numerals list

[0067] 1 Insert

[0068] 2 ampoules

[0069] 3. Introduction section

[0070] 4Introduction opening

[0071] 5 Output section

[0072] 6 output openings

[0073] 7 Transition section

[0074] 8 Guidance mechanism

[0075] 10. Flip the device

[0076] 11 The First Lair

[0077] 12 The Second Lair

[0078] 13 basins

[0079] 14 Actuator

[0080] 15 strokes

[0081] 16 Suction gripper

[0082] 17 First Arm

[0083] 18 Second Arm

[0084] 19 Positioning auxiliary device

[0085] 20 Connecting arm

[0086] 21 Distance Element

[0087] H Main motion direction

[0088] R1 First Direction

[0089] H1 First Axis

Claims

1. An insert (1) for a turning device (10) for a medical ampoule (2), the insert comprising: an introduction section (3) having a plurality of introduction openings (4) for receiving each ampoule (2), wherein the introduction openings (4) are arranged in a first arrangement, an output section (5) having a plurality of output openings (6) for outputting each ampoule (2), wherein the output openings (6) are arranged in a second arrangement, and a transition section (7) having a plurality of guide means (8), wherein the transition section (7) is arranged and / or designed such that the ampoule (2) can be guided from the introduction opening (4) through the guide means (8) to the discharge opening (6), The inlet opening (4) and the outlet opening (6) are arranged eccentrically relative to one another. 2 . The insert element ( 1 ) according to claim 1 , wherein the introduction opening ( 4 ) and the discharge opening ( 6 ) are arranged offset with respect to one another in a plan view of the insert element ( 1 ). 3 . The insert ( 1 ) according to claim 1 , wherein the introduction section ( 3 ), the discharge section ( 5 ) and the transition section ( 7 ) are integrally formed.

4. An insert (1) according to any of the above claims, wherein each guide mechanism (8) includes at least one braking section, which is designed to reduce the movement speed of the ampoule (2) when guiding from the introduction section (3) to the output section (5).

5. Insert (1) according to any one of the preceding claims, wherein the insert (1) comprises polyoxymethylene, polyamide, polytetrafluoroethylene and / or polyethylene terephthalate.

6. A turning device (10) for turning over a medical ampoule (2), the turning device comprising: An insert (1) according to any one of the preceding claims, a holding device (13) for holding the insert (1), wherein the holding device (13) is designed to move the insert (1) along a first direction (R1), The holding device (13) is designed to rotate the insert (1) about a first axis (A1).

7. The turning device (10) according to claim 6, wherein the first direction (R1) and the first axis (A1) are orthogonal to each other.

8. The turning device (10) according to claim 6 or 7, wherein the turning device (10) comprises an actuator (14), wherein the actuator (14) is designed to perform a movement along the first direction (R1) and a rotation around the first axis (A1).

9. The turning device (10) according to any one of claims 6 to 8, wherein the turning device (10) has a control unit, which is designed to obtain the original position of the medical ampoule (2) and determine the new position of the medical ampoule (2) after leaving the output opening (6).

10. The turning device (10) according to claim 6 , wherein the holding device (10) is designed to hold a first nest (11) having a plurality of ampoule holding positions in such a way that each ampoule holding position is opposite one of the introduction openings (4), and / or The holding device (13) is designed to hold a second nest (12) having a plurality of ampoule holding positions in such a way that each ampoule holding position is located opposite one of the dispensing openings (6).

11. A flipping device (10) according to any one of claims 6 to 10, wherein the flipping device (10) includes at least one positioning aid (19), which is designed to ensure a predetermined position of the nest (11, 12) when the nest (11, 12) contacts the flipping device (10).

12. A method for turning over a medical ampoule (2) by means of an insert (1), the method comprising: providing a plurality of medical ampoules (2) in a first arrangement, The ampoule (2) is received in each introduction opening (4) of the insert (1), The ampoule (2) is guided from the introduction opening (4) to the output opening (6) of the insert (1) via a guide mechanism (8) of the insert (1), discharging the ampoule from the discharging opening (6) in a second arrangement, The first arrangement structure is different from the second arrangement structure.

Images