Traditional Chinese medicine composition for improving pain after anus operation and promoting wound healing and preparation method thereof

Abstract

The embodiment of the invention discloses a traditional Chinese medicine composition for relieving pain after an anus operation and promoting wound healing and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 40 to 50 parts of dragon's blood, 95 to 105 parts of frankincense, 95 to 105 parts of myrrh, 25 to 35 parts of pearl, 55 to 65 parts of silver bead, 70 to 80 parts of cuttlebone, 55 to 65 parts of yellow lead, 100 to 110 parts of red halloysite, 55 to 65 parts of dragon bone, 70 to 80 parts of calomel, 12 to 18 parts of borneol and 12 to 18 parts of artificial musk. The traditional Chinese medicine composition provided by the invention has various effects of promoting blood circulation to remove blood stasis, diminishing swelling, promoting tissue regeneration and the like, can relieve postoperative pain of a patient and promote postoperative wound healing, is high in safety and has a relatively good clinical popularization value.

Description

Technical Field

[0001] The embodiments of the present invention relate to the technical field of traditional Chinese medicine, and specifically to a traditional Chinese medicine composition for improving pain after anal surgery and promoting wound healing and a preparation method thereof. Background Art

[0002] Anal surgery refers to surgery for diseases in and around the anorectal cavity that require surgical treatment. The most common surgery is hemorrhoid surgery, including internal hemorrhoid ligation, internal hemorrhoid injection, external hemorrhoidectomy, mixed hemorrhoid external ligation, PPH, RPH, TST, etc. In addition, there are also anal fissure resection, internal sphincter release, incision and drainage of perianal abscesses, anal fistula resection, etc.

[0003] Due to the particularity of the local anatomical structure of the anus and the functional characteristics of anal defecation, the wound surface after anal disease surgery is generally open instead of closed suture. After the operation, there will be more obvious pain symptoms, as well as adverse reactions and complications such as delayed wound healing time, which will affect postoperative recovery and have a serious impact on the patient's physical and mental health and quality of life.

[0004] Currently, drug treatment (such as appropriate selection and use of nonsteroidal anti-inflammatory drugs, anesthetics, and opioids), nerve blocks, and local analgesics are used to reduce postoperative pain. At the same time, professional wound care, including cleaning, disinfection, and sterile dressing changes, is performed regularly to prevent infection and promote wound healing. However, there is a problem of poor clinical treatment effect. Therefore, it is particularly important to find a safe and effective postoperative treatment method for anus that can effectively reduce pain and promote rapid wound healing. Summary of the invention

[0005] To this end, the embodiments of the present invention provide a Chinese medicine composition and a preparation method for improving pain after anal surgery and promoting wound healing. The Chinese medicine composition is an ancestral prescription, which has been proven to be able to effectively improve pain after anal surgery and promote wound healing through a large number of clinical trials, and has passed the approval and appraisal of the "Intangible Cultural Heritage Project".

[0006] In order to achieve the above purpose, the embodiment of the present invention provides the following technical solutions:

[0007] According to a first aspect of an embodiment of the present invention, the present invention provides a traditional Chinese medicine composition for improving pain after anal surgery and promoting wound healing, wherein the traditional Chinese medicine composition comprises, by weight: 40-50 parts of dragon's blood, 95-105 parts of frankincense, 95-105 parts of myrrh, 25-35 parts of pearls, 55-65 parts of silver beads, 70-80 parts of cuttlebone, 55-65 parts of yellow ochre, 100-110 parts of red ochre, 55-65 parts of dragon bones, 70-80 parts of light powder, 12-18 parts of borneol, and 12-18 parts of artificial musk.

[0008] Furthermore, the Chinese medicine composition comprises, by weight: 45 parts of dragon's blood, 100 parts of frankincense, 100 parts of myrrh, 30 parts of pearls, 60 parts of silver beads, 75 parts of cuttlefish, 60 parts of yellow ochre, 105 parts of red ochre, 60 parts of dragon bones, 75 parts of talcum powder, 15 parts of borneol, and 15 parts of artificial musk.

[0009] Furthermore, the dosage form of the Chinese medicine composition is an external preparation.

[0010] Furthermore, the external preparation is a powder.

[0011] According to a second aspect of an embodiment of the present invention, the present invention provides a method for preparing the above-mentioned Chinese medicine composition for improving pain after anal surgery and promoting wound healing, comprising weighing each medicinal material according to a weight ratio, mixing, and then crushing and sieving.

[0012] Furthermore, the sieved particle size is 200-300 mesh.

[0013] The effects of each raw material used in the present invention are as follows:

[0014] Xuejie: ​​sweet and salty in taste, neutral in nature. Enters the heart and liver meridians. Disperses blood stasis, relieves pain, stops bleeding and promotes tissue regeneration.

[0015] Frankincense: pungent, bitter, slightly warm. Heart meridian, liver meridian, spleen meridian. Regulates qi and activates blood circulation, relieves pain, and removes toxins.

[0016] Myrrh: pungent, bitter, neutral in nature. Enters the heart, liver, and spleen meridians. Disperses blood stasis, relieves pain, reduces swelling, and promotes tissue regeneration.

[0017] Pearl: sweet; salty; cold in nature. Heart meridian; liver meridian. Calms the mind and soothes the nerves, nourishes yin and extinguishes wind, clears away heat and dispels phlegm, removes cataracts and improves eyesight, detoxifies and promotes tissue regeneration.

[0018] Silver beads: also known as silver vermilion, spicy, warm, poisonous. Enter the heart and lung meridians. Fight poison, kill insects, dry dampness, and eliminate phlegm.

[0019] Cuttlebone: salty, astringent, warm in nature. Enters the spleen and kidney meridians. Astringent and hemostatic, astringent and leukorrhea-stopping, acid-reducing and analgesic, and dampness-reducing and sore-healing.

[0020] Huang Dan: pungent, slightly cold. Enters the heart, spleen and liver meridians. Removes toxins, promotes tissue regeneration, kills insects and relieves itching.

[0021] Red ochre: sweet, sour, astringent, warm. Enters the stomach meridian and large intestine meridian. Astringes the intestines, stops bleeding, absorbs dampness, and promotes tissue regeneration.

[0022] Dragon bone: astringent, sweet, neutral in nature. Enters the heart, liver, and kidney meridians. Calms the mind and soothes the nerves, soothes the liver and suppresses yang, consolidates and astringes.

[0023] Light powder: pungent, cold, toxic. Enters the large intestine and small intestine meridians. Used externally to kill insects, attack toxins, and heal sores.

[0024] Borneol: pungent, bitter, slightly cold. Enters the heart meridian, spleen meridian, and lung meridian. Refreshes the mind, dissipates heat and relieves pain, brightens the eyes and removes cataracts.

[0025] Artificial musk: aromatic, invigorating the mind, promoting blood circulation and dredging meridians, reducing swelling and relieving pain.

[0026] The compatibility relationship of the Chinese medicine composition for improving pain after anal surgery and promoting wound healing provided by the present invention is as follows:

[0027] Main drug:

[0028] Xuejie: ​​It has the effects of promoting blood circulation and relieving pain, removing blood stasis and promoting tissue regeneration. It is the main medicine for treating blood stasis pain symptoms, pain after anal surgery and promoting wound healing. Therefore, it is used as the main medicine.

[0029] Assistant medicine (auxiliary medicine):

[0030] Frankincense and myrrh: Both herbs have the effects of promoting blood circulation and relieving pain, reducing swelling and promoting tissue regeneration, and they assist Xuejie in strengthening the ability to promote blood circulation and remove blood stasis;

[0031] Pearls and silver beads: have the effects of detoxification, tissue regeneration, astringency and hemostasis, assist the main medicine in treating wounds and promote healing of perianal wounds.

[0032] Adjuvant:

[0033] Cuttlebone: astringent and hemostatic, firming and tissue regeneration, auxiliary treatment of wounds, and auxiliary hemostatic effect for postoperative bleeding;

[0034] Huang Dan, Red Ochre and Dragon Bone: All three have the effect of astringing and consolidating, and are used to consolidate wounds and prevent leakage. They can also assist other drugs in alleviating local inflammation.

[0035] Calomel: It has the effects of detoxification, insecticide, astringency and hemostasis, and can assist other drugs in treating infected wounds.

[0036] Drug:

[0037] Borneol and artificial musk: clear away heat and relieve pain, wake up the mind and open the orifices, disperse blood stasis and promote blood circulation, relieve local inflammation and pain, and are used to guide the medicine directly to the affected area, enhancing the penetration and efficacy of the prescription.

[0038] The embodiments of the present invention have the following advantages:

[0039] 1. The Chinese medicine composition provided by the present invention uses specific amounts of dragon's blood, frankincense, myrrh, pearls, silver beads, cuttlebone, yellow ochre, red ochre, dragon bone, light powder, borneol, and artificial musk as raw materials. The components exert the greatest synergistic effect, have the effects of promoting blood circulation, reducing swelling and promoting tissue regeneration, can relieve patients' postoperative pain, promote postoperative wound healing, and have high safety and good clinical promotion value.

[0040] 2. The external preparation provided by the present invention has obvious advantages over other oral preparations, such as good efficacy and fewer side effects. DETAILED DESCRIPTION

[0041] The following is a description of the implementation of the present invention by specific embodiments. People familiar with the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0042] Example 1

[0043] The present embodiment provides a Chinese medicine composition for improving pain after anal surgery and promoting wound healing, wherein the raw materials are: 40g of dragon's blood, 98g of frankincense, 102g of myrrh, 28g of pearls, 61g of silver beads, 73g of cuttlebone, 55g of yellow ochre, 104g of red ochre, 60g of dragon bone, 75g of light powder, 15g of borneol, and 18g of artificial musk.

[0044] The preparation method of the composition comprises: weighing various medicinal materials according to the weight ratio, mixing, and then crushing and passing through a 240 sieve.

[0045] Example 2

[0046] The present embodiment provides a Chinese medicine composition for improving pain after anal surgery and promoting wound healing, the raw materials of which are: 45g of dragon's blood, 100g of frankincense, 100g of myrrh, 30g of pearls, 60g of silver beads, 75g of cuttlebone, 60g of yellow ochre, 105g of red ochre, 60g of dragon bone, 75g of light powder, 15g of borneol, and 15g of artificial musk.

[0047] The preparation method of the above composition is the same as that of Example 1.

[0048] Example 3

[0049] The present embodiment provides a Chinese medicine composition for improving pain after anal surgery and promoting wound healing, wherein the raw materials are: 48g of dragon's blood, 95g of frankincense, 100g of myrrh, 35g of pearls, 58g of silver beads, 70g of cuttlebone, 65g of yellow ochre, 108g of red ochre, 55g of dragon bone, 72g of light powder, 16g of borneol, and 16g of artificial musk.

[0050] The preparation method of the above composition is the same as that of Example 1.

[0051] Example 4

[0052] The present embodiment provides a Chinese medicine composition for improving pain after anal surgery and promoting wound healing, the raw materials of which are: 46g of dragon's blood, 103g of frankincense, 96g of myrrh, 32g of pearls, 55g of silver beads, 78g of cuttlebone, 62g of yellow ochre, 100g of red ochre, 64g of dragon bone, 78g of light powder, 12g of borneol, and 16g of artificial musk.

[0053] The preparation method of the above composition is the same as that of Example 1.

[0054] Example 5

[0055] The present embodiment provides a Chinese medicine composition for improving pain after anal surgery and promoting wound healing, the raw materials of which are: 50g of dragon's blood, 105g of frankincense, 103g of myrrh, 25g of pearls, 64g of silver beads, 80g of cuttlebone, 55g of yellow ochre, 110g of red ochre, 58g of dragon bone, 80g of light powder, 15g of borneol, and 12g of artificial musk.

[0056] The preparation method of the above composition is the same as that of Example 1.

[0057] Test Example 1

[0058] This test example is used to illustrate the clinical effect of the Chinese medicine composition for improving pain after anal surgery and promoting wound healing provided by the embodiment of the present invention.

[0059] 1. General Information

[0060] A total of 180 patients admitted to the Department of Anorectal Surgery of our hospital were selected, and the diagnosis results included: rectal mucosal prolapse, high anal fistula, perianal abscess, complex anal fistula, gluteal infected sinus, anal fistula, anal canal inflammation, mixed hemorrhoids, unilateral inguinal hernia, ileal ulcer, colorectal hernia, puborectalis hypertrophy, benign colon tumor, anal stenosis, colon polyp, radiation proctitis, benign colon tumor. Among them: 88 males and 92 females, aged 33-61 years old. All patients underwent anal surgery and were randomly divided into two groups, treatment group 1 and treatment group 2, 90 people / group. There was no statistically significant difference in gender, age and course of disease between the two groups (P>0.05), and they were comparable.

[0061] 2. Methods

[0062] Treatment Group 1 was treated with the Chinese medicine composition of Example 2, and Treatment Group 2 was treated with the Chinese medicine composition of Example 4.

[0063] Usage: On the second day after surgery, first clean the wound surface of the patient with a sterilized dry cotton ball, and then evenly spray the Chinese medicine composition of the embodiment of the present invention on the wound surface, once in the morning and once in the evening, and 7 days is a course of treatment.

[0064] 3. Observation methods and efficacy determination

[0065] The anal pain score was formulated based on the IV-degree classification standard developed by the National Anorectal Academic Conference in 1975. The higher the score, the more severe the pain symptom (the total score is 10 points).

[0066] The wound healing efficacy was determined according to the “Standards for Diagnosis and Efficacy of Clinical Diseases in Traditional Chinese Medicine”.

[0067] Cure: The wound is completely covered by epithelial tissue, and no false healing is observed at the base of the wound, with a healing rate of 100%;

[0068] Significantly effective: fresh granulation tissue of the incision, no abnormal hyperplasia of granulation tissue, no abnormal secretion, 75%≤healing rate<100%;

[0069] Effective: The granulation tissue on the wound surface is relatively fresh, with a small amount of secretions attached, and the healing rate is 25%≤<75%;

[0070] Ineffective: The granulation tissue on the wound edge is uneven, dark in color, and has a large amount of secretions attached, and the healing rate is <25%.

[0071] 4. Results

[0072] After one course of treatment, the results of wound pain and wound healing efficacy in the two groups were as follows:

[0073] 1. The comparison results of wound pain levels between the two groups are shown in Table 1 below.

[0074] Table 1

[0075] Group 3 days after surgery 7 days after surgery Treatment Group 1 5.8±0.8 1.5±0.4 Treatment Group 2 6.5±0.6 1.9±0.5

[0076] 2. The comparison results of wound healing efficacy between the two groups are shown in Table 2.

[0077] Table 2

[0078]

[0079]

[0080] The results show that the Chinese medicine composition provided by the embodiment of the present invention can significantly reduce the postoperative pain of patients, effectively promote postoperative wound healing, and has excellent clinical effects. At the same time, all patients were observed, and no one had allergic reaction symptoms, indicating that the Chinese medicine composition provided by the embodiment of the present invention is highly safe and has good clinical promotion value.

[0081] Although the present invention has been described in detail above by general description and specific embodiments, it is obvious to those skilled in the art that some modifications or improvements can be made to the present invention. Therefore, these modifications or improvements made without departing from the spirit of the present invention all belong to the scope of protection claimed by the present invention.

Claims

1. A Chinese medicine composition for improving pain after anal surgery and promoting wound healing, characterized in that: The traditional Chinese medicine composition comprises, by weight, 40-50 parts of dragon's blood, 95-105 parts of frankincense, 95-105 parts of myrrh, 25-35 parts of pearls, 55-65 parts of silver beads, 70-80 parts of cuttlebone, 55-65 parts of yellow ochre, 100-110 parts of red ochre, 55-65 parts of dragon bone, 70-80 parts of talcum powder, 12-18 parts of borneol and 12-18 parts of artificial musk.

2. The Chinese medicine composition for improving pain after anal surgery and promoting wound healing according to claim 1, characterized in that: The Chinese medicine composition comprises, by weight, 45 parts of dragon's blood, 100 parts of frankincense, 100 parts of myrrh, 30 parts of pearls, 60 parts of silver beads, 75 parts of cuttlebone, 60 parts of yellow ochre, 105 parts of red ochre, 60 parts of dragon bone, 75 parts of talcum powder, 15 parts of borneol, and 15 parts of artificial musk.

3. The Chinese medicine composition for improving pain after anal surgery and promoting wound healing according to claim 1, characterized in that: The dosage form of the Chinese medicine composition is an external preparation.

4. The Chinese medicine composition for improving pain after anal surgery and promoting wound healing according to claim 3, characterized in that: The external preparation is a powder.

5. A method for preparing the Chinese medicine composition for improving pain after anal surgery and promoting wound healing as claimed in claim 1, characterized in that: Weigh each medicinal material according to the weight ratio, mix them, and then crush and sieve them.

6. The method according to claim 5, characterized in that The sieved particle size is 200-300 meshes.

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