Plaster for relieving swelling and pain of pyretic arthralgia and preparation method thereof

Abstract

The invention discloses swelling and pain relieving ointment for pyretic arthralgia and a preparation method thereof. The swelling and pain relieving ointment is prepared from the following components: 30 to 50 parts of radix et rhizoma rhei, 30 to 50 parts of radix scutellariae, 30 to 50 parts of cortex phellodendri, 30 to 50 parts of radix angelicae, 30 to 50 parts of rhizoma arisaematis, 30 to 50 parts of radix trichosanthis, 10 to 20 parts of rhizoma atractylodis, 30 to 50 parts of rhizoma curcumae longae, 20 to 40 parts of myrrh, 10 to 20 parts of mirabilite, 10 to 20 parts of alum and 5 to 15 parts of borneol. The swelling and pain relieving ointment for pyretic arthralgia has remarkable effects of diminishing inflammation, relieving swelling and relieving pain. Clinical application verifies that the traditional Chinese medicine composition can quickly relieve aseptic inflammation and red, swollen and heat pain symptoms of joints and local soft tissues. The external use mode is convenient and practical, and patients can operate by themselves without complex procedures. Meanwhile, the plaster adopts a pure traditional Chinese medicine formula, is nontoxic and free of side effects, and avoids irritation of oral medicines to gastrointestinal tracts. According to the traditional Chinese medicine composition, cold medicines are used as main medicines, meanwhile, warm medicines such as rhizoma arisaematis and radix angelicae are combined, and cold and warm medicines are used together, so that the main effects of clearing heat and eliminating dampness are guaranteed, cold congealing and dampness obstructing caused by excessive cold and cool are prevented, and the ingenious idea of'counter-assistant 'of traditional Chinese medicine is embodied.

Description

Technical Field

[0001] This invention relates to the field of external preparations of traditional Chinese medicine, specifically to a heat-relieving, swelling-reducing, and pain-relieving plaster and its preparation method. Background Technology

[0002] In Traditional Chinese Medicine (TCM) theory, symptoms such as swelling, pain, and difficulty in flexion and extension of muscles and joints are classified as "Bi syndrome." External application of Chinese medicine to treat Bi syndrome has a history of over a thousand years. Applying Chinese medicine externally to the affected area not only effectively relieves local symptoms of redness, swelling, heat, and pain, but also allows the medicine to penetrate directly to the affected area, significantly improving treatment efficacy. Furthermore, external application of Chinese medicine reduces gastrointestinal irritation and has many advantages, including convenience, affordability, few side effects, and high patient acceptance. For example, Sanfu Patch is a typical example of external application of Chinese medicine regulating the functions of the internal organs, meridians, and blood circulation. However, most topical medications currently on the market for treating arthralgia primarily target cold-type arthralgia caused by wind, cold, and dampness, resulting in joint pain and aversion to wind and cold. Examples include wind-dispelling and pain-relieving plasters, musk-infused blood-activating and stasis-removing plasters, and Qizheng pain-relieving plasters. However, topical plasters for heat-type arthralgia, caused by invasion of damp-heat or prolonged stagnation of cold and dampness transforming into heat, resulting in redness, swelling, and pain in the joints and surrounding soft tissues, are extremely rare. Furthermore, the manufacturing processes of some existing topical plasters are rather "crude," severely affecting the transdermal absorption of the topical formula and hindering the drug from exerting its intended therapeutic effect. Therefore, developing a topical medication specifically targeting "local redness, swelling, heat, and pain in the joints," with detoxifying, swelling-reducing, and pain-relieving effects to meet clinical treatment needs, as well as improving the manufacturing process and increasing the transdermal absorption rate, have become urgent problems to be solved. Summary of the Invention

[0003] The purpose of this invention is to provide a heat-relieving, swelling-reducing, and pain-relieving plaster and its preparation method, so as to solve the problems mentioned in the background art.

[0004] To achieve the above objectives, the present invention provides the following technical solution: a heat-relieving, swelling-reducing, and pain-relieving plaster, comprising the following ingredients: 30-50 parts rhubarb, 30-50 parts scutellaria baicalensis, 30-50 parts phellodendron chinense, 30-50 parts angelica dahurica, 30-50 parts arisaema heterophyllum, 30-50 parts trichosanthes kirilowii, 10-20 parts atractylodes lancea, 30-50 parts turmeric, 20-40 parts myrrh, 10-20 parts mirabilite, 10-20 parts alum, and 5-15 parts borneol.

[0005] Preferred ingredients include the following: 40 parts rhubarb, 40 parts scutellaria baicalensis, 40 parts phellodendron chinense, 40 parts angelica dahurica, 40 parts arisaema heterophyllum, 40 parts trichosanthes kirilowii, 16 parts atractylodes lancea, 40 parts turmeric, 30 parts myrrh, 16 parts mirabilite, 16 parts alum, and 10 parts borneol.

[0006] In this formula, rhubarb, scutellaria, and phellodendron are used as the principal herbs, primarily for clearing heat and detoxifying, drying dampness and reducing swelling; trichosanthes root, angelica root, arisaema, and atractylodes are used as assistant herbs, with the effects of drying dampness, reducing swelling and dissipating nodules; turmeric and myrrh invigorate blood circulation, remove blood stasis, reduce swelling and relieve pain; alum and mirabilite, used externally, can dry dampness, reduce swelling and relieve pain, serving as adjuvant herbs; borneol is used as the guiding herb, providing transdermal analgesia. The specific medicinal properties and effects of each herb are as follows: Rhubarb: It is bitter and cold in nature, and can clear heat and purge fire, cool blood and detoxify, and remove blood stasis and promote menstruation. Scutellaria baicalensis: It is bitter and cold in nature, and has the effects of clearing heat and drying dampness, purging fire and detoxifying, and stopping bleeding. Phellodendron bark: It is bitter and cold in nature, and can clear heat and dry dampness, purge fire and detoxify. Trichosanthes kirilowii: It is sweet, slightly bitter, and slightly cold in nature. It can clear heat, reduce swelling, and drain pus. Angelica dahurica: It is pungent and warm in nature, and can remove dampness, reduce swelling and drain pus, open the orifices and relieve pain. Arisaema: It is bitter, pungent and warm in nature. It has the functions of drying dampness and resolving phlegm, dispersing nodules and reducing swelling. It can be used externally to treat carbuncles and snake and insect bites.

[0007] Atractylodes lancea: It is pungent, bitter and warm in nature, and has the functions of drying dampness, strengthening the spleen, dispelling wind and cold. Turmeric: It is bitter, pungent, and warm in nature. It can promote blood circulation, relieve pain, reduce swelling, and dissipate nodules. Myrrh: It is pungent, bitter, and neutral in nature, and can disperse blood stasis, reduce swelling, and relieve pain. Alum: It is acidic, astringent, and cold in nature. When used externally, it has the effects of detoxification and drying dampness. Glauber's salt: Salty, bitter, and cold in nature; it moistens dryness, softens hardened masses, clears heat, and reduces swelling. Externally used to treat mastitis and hemorrhoid swelling and pain. 03:13 Borneol: It is pungent and cool in nature, and can open the orifices and refresh the mind, clear heat and relieve pain.

[0008] A method for preparing a heat-relieving, swelling-reducing, and pain-relieving plaster includes the following steps: Step 1: Prepare the medicinal materials: 400 parts rhubarb, 400 parts scutellaria baicalensis, 400 parts phellodendron chinense, 400 parts angelica dahurica, 400 parts arisaema heterophyllum, 600 parts trichosanthes kirilowii, 400 parts turmeric, 200 parts mirabilite, 150 parts atractylodes lancea, 160 parts myrrh, 160 parts alum, and 100 parts borneol; Step 2: Grind half of the medicinal materials in the prescription, namely 300 parts of Trichosanthes kirilowii, 200 parts of rhubarb, 200 parts of Scutellaria baicalensis, 200 parts of Phellodendron chinense, 200 parts of Curcuma longa, 200 parts of Angelica dahurica, 200 parts of Arisaema heterophyllum, 80 parts of Atractylodes lancea, 80 parts of myrrh, and 80 parts of licorice, as well as all of the ingredients, including 150 parts of alum, 100 parts of borneol, and 100 parts of Glauber's salt, into powder. Crush the above medicinal materials to a diameter of 0.1-0.2 mm, then bottle and seal for later use. Step 3: Take the other half of the medicinal materials, namely 300 parts of Trichosanthes kirilowii, 200 parts of rhubarb, 200 parts of Scutellaria baicalensis, 200 parts of Phellodendron chinense, 200 parts of Curcuma longa, 200 parts of Angelica dahurica, 200 parts of Arisaema heterophyllum, 80 parts of Atractylodes lancea, 80 parts of Commiphora myrrha, and 80 parts of Glycyrrhiza uralensis, and perform the following operations: Soak the Chinese herbs that need to be decocted in cold water for 30 minutes; Put the soaked herbs into a pot, add cold water, soak again for 30 minutes, then heat over high heat; after the liquid boils, turn to low heat and simmer for 40 minutes, keeping the temperature at 100 degrees Celsius, and extract the original liquid. Add water to the pot again, bring it to a boil over high heat, then simmer over low heat for 40 minutes. Finally, strain out the dregs to obtain the original liquid from the second decoction. Step 4: After the decoction is finished, remove it from the heat and pour half of the prepared herbal powder from Step 2 into the original decoction for mixing. Then, perform low-temperature concentration extraction. After extraction, mix the remaining half of the herbal powder, then add sesame oil and lauryl ketone, and stir to form a paste. During the preparation process, adjust the consistency of the paste by adding sesame oil and lauryl ketone. After adjusting to the appropriate consistency, stir while cooling until a uniform paste is formed. Finally, seal and bottle for later use. Step 5: When using, spread the hot compress into a medicated cake with a diameter of 8-10cm and a thickness of 2-3mm, place it on a non-woven fabric, apply it to the affected area, and fix it with a bandage or adhesive tape; each application time is 6 hours, and it should be changed once a day.

[0009] Preferably, in step three, the amount of cold water added is 1200-1500ml, and the amount of clean water added is 800-1000ml.

[0010] Compared with the prior art, the beneficial effects of the present invention are: This invention's heat-relieving, swelling-reducing, and pain-relieving plaster has significant anti-inflammatory, swelling-reducing, and pain-relieving effects. Clinical application has verified that it can quickly relieve symptoms of redness, swelling, heat, and pain in joints and local soft tissues. The external application method is convenient and practical; patients can apply it themselves without complicated procedures. Furthermore, this plaster uses a pure traditional Chinese medicine formula, is non-toxic, has no side effects, and avoids the gastrointestinal irritation caused by oral medications. The entire formula is dominated by cold-natured herbs, while also incorporating warm-natured herbs such as Arisaema heterophyllum and Angelica dahurica. This combination of cold and warm properties ensures the main efficacy of clearing heat and removing dampness while preventing excessive coldness from causing stagnation and obstruction of dampness, reflecting the ingenious concept of "counteracting" in traditional Chinese medicine. Moreover, the external application method avoids the drawbacks of bitter and cold herbs damaging the spleen and stomach, conforming to the principles of traditional Chinese medicine. Detailed Implementation

[0011] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0012] This invention provides a plaster for relieving swelling and pain caused by heat-induced arthralgia, comprising the following ingredients: 30-50 parts rhubarb, 30-50 parts scutellaria baicalensis, 30-50 parts phellodendron chinense, 30-50 parts angelica dahurica, 30-50 parts arisaema heterophyllum, 30-50 parts trichosanthes kirilowii, 10-20 parts atractylodes lancea, 30-50 parts turmeric, 20-40 parts myrrh, 10-20 parts mirabilite, 10-20 parts alum, and 5-15 parts borneol.

[0013] Preferred ingredients include the following: 40 parts rhubarb, 40 parts scutellaria baicalensis, 40 parts phellodendron chinense, 40 parts angelica dahurica, 40 parts arisaema heterophyllum, 40 parts trichosanthes kirilowii, 16 parts atractylodes lancea, 40 parts turmeric, 30 parts myrrh, 16 parts mirabilite, 16 parts alum, and 10 parts borneol.

[0014] In this formula, rhubarb, scutellaria, and phellodendron are used as the principal herbs, primarily for clearing heat and detoxifying, drying dampness and reducing swelling; trichosanthes root, angelica root, arisaema, and atractylodes are used as assistant herbs, with the effects of drying dampness, reducing swelling and dissipating nodules; turmeric and myrrh invigorate blood circulation, remove blood stasis, reduce swelling and relieve pain; alum, used externally, dries dampness, reduces swelling and relieves pain, serving as an adjuvant herb; borneol is used as the guiding herb, providing transdermal analgesia. The specific medicinal properties and effects of each herb are as follows: Rhubarb: It is bitter and cold in nature, and can clear heat and purge fire, cool blood and detoxify, and remove blood stasis and promote menstruation. Scutellaria baicalensis: It is bitter and cold in nature, and has the effects of clearing heat and drying dampness, purging fire and detoxifying, and stopping bleeding. Phellodendron bark: It is bitter and cold in nature, and can clear heat and dry dampness, purge fire and detoxify. Trichosanthes kirilowii: It is sweet, slightly bitter, and slightly cold in nature. It can clear heat, reduce swelling, and drain pus. Angelica dahurica: It is pungent and warm in nature, and can remove dampness, reduce swelling and drain pus, open the orifices and relieve pain. Atractylodes lancea: It is pungent, bitter and warm in nature, and has the functions of drying dampness, strengthening the spleen, dispelling wind and cold. Turmeric: It is bitter, pungent, and warm in nature. It can promote blood circulation, relieve pain, reduce swelling, and dissipate nodules. Myrrh: It is pungent, bitter, and neutral in nature, and can disperse blood stasis, reduce swelling, and relieve pain. Alum: It is acidic, astringent, and cold in nature. When used externally, it has the effects of detoxification and drying dampness. Borneol: It is pungent and cool in nature, and can open the orifices and refresh the mind, clear heat and relieve pain.

[0015] A method for preparing a heat-relieving, swelling-reducing, and pain-relieving plaster includes the following steps: Step 1: Prepare the medicinal materials: 400 parts rhubarb, 400 parts scutellaria baicalensis, 400 parts phellodendron chinense, 400 parts angelica dahurica, 400 parts arisaema heterophyllum, 600 parts trichosanthes kirilowii, 400 parts turmeric, 200 parts mirabilite, 150 parts atractylodes lancea, 160 parts myrrh, 160 parts alum, and 100 parts borneol; Step 2: Grind half of the medicinal materials in the prescription, namely 300 parts of Trichosanthes kirilowii, 200 parts of rhubarb, 200 parts of Scutellaria baicalensis, 200 parts of Phellodendron chinense, 200 parts of Curcuma longa, 200 parts of Angelica dahurica, 200 parts of Arisaema heterophyllum, 80 parts of Atractylodes lancea, 80 parts of myrrh, and 80 parts of licorice, as well as all of the ingredients, including 150 parts of alum, 100 parts of borneol, and 100 parts of Glauber's salt, into powder. Crush the above medicinal materials to a diameter of 0.1-0.2 mm, then bottle and seal for later use. Step 3: Take the other half of the medicinal materials, namely 300 parts of Trichosanthes kirilowii, 200 parts of rhubarb, 200 parts of Scutellaria baicalensis, 200 parts of Phellodendron chinense, 200 parts of Curcuma longa, 200 parts of Angelica dahurica, 200 parts of Arisaema heterophyllum, 80 parts of Atractylodes lancea, 80 parts of Commiphora myrrha, and 80 parts of Glycyrrhiza uralensis, and perform the following operations: Soak the Chinese herbs that need to be decocted in cold water for 30 minutes; Place the soaked herbs in a pot, add 1200-1500ml of cold water, soak again for 30 minutes, then heat over high heat; after the liquid boils, turn to low heat and simmer for 40 minutes, keeping the temperature at 100 degrees Celsius, and extract the original liquid. Add another 800-1000ml of water to the pot, bring it to a boil over high heat, then simmer over low heat for 40 minutes. Finally, strain out the dregs to obtain the original liquid from the second decoction. Step 4: After the decoction is finished, remove it from the heat and pour half of the prepared herbal powder from Step 2 into the original decoction for mixing. Then, perform low-temperature concentration extraction. After extraction, mix the remaining half of the herbal powder, then add sesame oil and lauryl ketone, and stir to form a paste. During the preparation process, adjust the consistency of the paste by adding sesame oil and lauryl ketone. After adjusting to the appropriate consistency, stir while cooling until a uniform paste is formed. Finally, seal and bottle for later use. When using, spread the hot compress into a paste with a diameter of 8-10cm and a thickness of 2-3mm, place it on a non-woven fabric, apply it to the affected area, and fix it with a bandage or adhesive tape; each application time is 6 hours, and it should be changed once a day.

[0016] Case 1: Mr. Li, male, 48 years old, a civil servant. The patient presented with recurrent redness, swelling, heat, and pain in his left ankle and toes for four years. He has a long-standing habit of drinking alcohol. One day prior, after consuming a high-purine diet, he suddenly experienced swelling and pain in his left ankle and toes, with slightly elevated local skin temperature and severe pain that significantly affected his sleep. Bowel movements and urination were normal. He was diagnosed with an acute gout attack. A topical application of a warming plaster was applied to the affected area, which was then secured with a bandage. The patient was also advised to drink plenty of water. One day later, his symptoms significantly improved, and the swelling and pain lessened. After continuing the application for five more days, the symptoms completely disappeared.

[0017] Case 2: Ms. Zhang, 75 years old, had a 12-year history of rheumatoid arthritis. Three months prior, she developed subcutaneous redness, swelling, heat, and pain on the lateral aspect of her right tibia without any obvious cause. A subcutaneous erythema approximately 6 cm long and 2-3 cm wide was observed, accompanied by pain. After receiving antibiotics and topical erythromycin at another hospital, the treatment was ineffective; the erythema gradually expanded into a large patch, the pain worsened, affecting her sleep, and her weight gradually decreased to 47 kg. Her bowel movements were normal, and her urine was slightly yellow. She was diagnosed with rheumatoid arthritis and subcutaneous erythema nodosum. In addition to her existing rheumatoid arthritis treatment plan, she was given a topical application of a warming plaster. After two days, her symptoms improved, and the swelling and pain lessened; after five more days of application, the symptoms essentially disappeared.

[0018] Case 3: Mr. Zhao, male, 36 years old, office worker. The patient had experienced recurrent swelling and pain in his wrist and ankle joints for over three years, and habitually preferred spicy and stimulating foods. Each flare-up was accompanied by redness, swelling, heat, and pain, severely impacting his daily life, with each flare lasting 3-7 days. In this current flare-up, his right ankle joint was severely red, swollen, and painful, affecting his mobility; sleep was fair, but his stools were sticky and his urine was slightly yellow. He was diagnosed with eczema-like rheumatism. He was given a topical application of a warming plaster, and after one day, his symptoms improved, with reduced swelling and pain; after three more days of continued application, the symptoms essentially disappeared, and the patient recovered completely.

[0019] The above cases fully demonstrate that the heat-relieving and swelling-reducing plaster of the present invention has the effects of clearing heat and detoxifying, removing dampness and reducing swelling, and quickly relieving pain. It is effective in eliminating redness, swelling, heat and pain in joints and local soft tissues, and is convenient to use, has few adverse reactions, and is safe and effective.

[0020] A prospective, randomized controlled clinical study was conducted to investigate the efficacy and safety of a heat-relieving and swelling-reducing plaster in treating acute gouty arthritis. The study included 160 participants, all of whom were acute gout patients admitted to the outpatient and inpatient departments of the Rheumatology Department of the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine between January 1, 2023, and December 31, 2024. The total number of patients was 160. The combined traditional Chinese medicine group consisted of 78 males and 2 females, aged 25–64 years (mean 43.4±7.1 years) with a disease duration of 0.4–12.0 years (mean 5.4±2.8 years). The celecoxib group consisted of 79 males and 1 female, aged 23–65 years (mean 46.6±6.2 years) with a disease duration of 0.5–15.0 years (mean 5.7±2.0 years). There were no statistically significant differences in general characteristics between the two groups (P>0.05), indicating comparability.

[0021] Of the 79 patients, 40 had the first toe joint, 40 had the midfoot joint, and 41 had the ankle joint. 92 patients had their first attack, and 68 had multiple attacks. 40 patients had obvious tophi. 103 patients had serum uric acid ≥600 μmol / L, 38 had 480–599 μmol / L, and 19 had 360–479 μmol / L. 48 patients had double-track sign on ultrasound, 125 had urate deposition on dual-energy CT, and 14 had bone erosion on X-ray.

[0022] Two patients dropped out in both the combined traditional Chinese medicine group and the celecoxib group. The dropout in the combined traditional Chinese medicine group was due to redness and itching of the affected skin after the first application of the heat-relieving and swelling-reducing plaster, which led to the discontinuation of the plaster. The dropout in the celecoxib group was due to two patients not being able to follow up on time. Therefore, a total of 156 patients were enrolled, including 78 patients in the celecoxib group and 78 patients in the treatment group.

[0023] 1. Comparison of inflammatory markers CRP, TNF-α, and IL-1β before and after treatment in the two groups of patients. There were no significant differences in CRP, TNF-α, and IL-1β levels between the two groups before treatment. P >0.05), allowing for comparison; after 7 days of treatment, the levels of CRP, TNF-α, and IL-1β in both groups were significantly lower than before treatment, with a more significant decrease in the combined traditional Chinese medicine group, and the difference was statistically significant. P <0.05). (See Tables 1, 2, and 3) Table 1 Comparison of CRP treatment before and after treatment in the two groups ( ) ; The normal reference range for CRP is 0-10 mg / L.

[0024] Table 2 Comparison of TNF-α treatment before and after treatment in the two groups ( (±s, pg / mL) ; The normal reference range for TNF-α is ≤8.5 pg / mL.

[0025] Table 3 Comparison of IL-1β treatment before and after treatment in the two groups ( (±s, pg / mL) ; The normal reference range for IL-1β is ≤12.4 pg / mL.

[0026] 2. Comparison of VAS scores before and after treatment in the two groups of patients. Repeated measures ANOVA results showed no statistically significant difference in VAS between groups (F... 组间 =0.30, P 组间 <0.001); the differences in VAS between different time points were statistically significant (F 时间 =98.05, P 时间 <0.001); the difference in the interaction between groups and time was statistically significant (F <0.001). 交互 =6.20, P 交互 <0.001).

[0027] Further pairwise comparisons showed that VAS scores in both groups were significantly lower before treatment and at 1, 3, and 7 days after treatment, with the combined traditional Chinese medicine group showing a more significant decrease compared to the celecoxib group, and the differences were statistically significant. P <0.001). (See Table 4) Table 4 Comparison of VAS scores before and after treatment in the two groups of patients ( ±s, minutes) ; VAS score: compared with pre-treatment score. Compared with the celecoxib group,

[0028] 3. Comparison of TCM syndrome scores before and after treatment between the two groups of patients There was no significant difference in the TCM syndrome scores between the two groups of patients before treatment. P >0.05), which allows for comparison; the TCM syndrome scores before and after treatment in both groups decreased significantly, and the difference was statistically significant. P <0.05); Comparing the TCM syndrome scores of the two groups after treatment, the combined TCM group showed a more significant decrease, and the difference was statistically significant. P <0.05). (See Table 5) Table 5 Comparison of TCM syndrome scores before and after treatment in the two groups of patients ( ±s, minutes) ; 5. Comparison of TCM clinical efficacy between the two groups of patients after treatment. Comparison of the clinical efficacy of traditional Chinese medicine before and after treatment in the two groups of patients: The combined Chinese medicine group had a higher effective rate and more patients with significant effects than the celecoxib group. The difference was statistically significant after rank-sum test. (See Table 6) Table 6 Comparison of the clinical efficacy of traditional Chinese medicine in the two groups of patients after treatment (%) ; 6. Adverse Reactions During treatment, no abnormalities were found in blood routine tests or liver and kidney function in either group. One patient in the celecoxib group experienced abdominal distension, and one patient in the combined traditional Chinese medicine group experienced rash and dry mouth; both symptoms improved significantly without treatment. There was no statistically significant difference in the incidence of adverse reactions between the two groups. =0.212, P>0.05).

[0029] Meanwhile, the clinical efficacy study of external application of Rebi San (also known as Rebi Xiaozhong Zhitong Gao) in the treatment of acute gout attacks has been successfully applied for the 2021 Henan Provincial Traditional Chinese Medicine Scientific Research Special Project.

[0030] In summary, the Rebi plaster has the effects of clearing heat and detoxifying, removing dampness and reducing swelling, and quickly relieving pain. It can eliminate redness, swelling, heat and pain in joints and local soft tissues. It is convenient to use, has few adverse reactions, and is safe and effective.

[0031] Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A plaster for relieving swelling and pain caused by heat-related arthritis, characterized in that, by weight It includes the following ingredients: 30-50 parts rhubarb, 30-50 parts scutellaria baicalensis, 30-50 parts phellodendron chinense, 30-50 parts angelica dahurica, 30-50 parts arisaema heterophyllum, 30-50 parts trichosanthes kirilowii, 10-20 parts atractylodes lancea, 30-50 parts turmeric, 20-40 parts myrrh, 10-20 parts mirabilite, 10-20 parts alum, and 5-15 parts borneol.

2. The heat-relieving, swelling-reducing, and pain-relieving plaster according to claim 1, characterized in that, The ingredients include: 40 parts rhubarb, 40 parts scutellaria baicalensis, 40 parts phellodendron chinense, 40 parts angelica dahurica, 40 parts arisaema heterophyllum, 40 parts trichosanthes kirilowii, 16 parts atractylodes lancea, 40 parts turmeric, 30 parts myrrh, 16 parts mirabilite, 16 parts alum, and 10 parts borneol.

3. The method for preparing a heat-relieving, swelling-reducing, and pain-relieving plaster according to claim 1 or 2, characterized in that, Includes the following steps: Step 1: Prepare the medicinal materials: rhubarb, scutellaria baicalensis, phellodendron chinense, angelica dahurica, arisaema heterophyllum, trichosanthes kirilowii, turmeric, mirabilite, atractylodes lancea, myrrh, alum, and borneol; Step 2: Grind half of the ingredients in the prescription—including Trichosanthes kirilowii, rhubarb, Scutellaria baicalensis, Phellodendron chinense, Curcuma longa, Angelica dahurica, Arisaema heterophyllum, Atractylodes lancea, Commiphora myrrha, and Glycyrrhiza uralensis—into a powder with a diameter of 0.1-0.2 mm. Then, bottle and seal the powder for later use. Step 3: Take the other half of the herbs, including pollen, rhubarb, scutellaria, phellodendron, turmeric, angelica, arisaema, atractylodes, myrrh, and licorice, and decoct them to obtain the original medicinal liquid. Step 4: Take half of the prepared medicinal powder from Step 2 and mix it with the original medicinal juice. Then, perform low-temperature concentration extraction. After extraction, mix the remaining half of the medicinal powder, add sesame oil and lauryl ketone, stir to form a paste, seal and bottle for later use.

4. The method for preparing a heat-relieving, swelling-reducing, and pain-relieving plaster according to claim 3, characterized in that, The specific steps for decocting the original medicinal liquid include the following: Soak the herbs that need to be decocted in cold water; Put the soaked herbs into a pot, add cold water, soak again, and then heat over high heat; after the liquid boils, turn to low heat and simmer slowly, keeping the temperature at 100 degrees Celsius, to obtain the original liquid of the decoction. Add more water to the pot, bring it to a boil over high heat, then simmer over low heat. Finally, strain out the dregs to obtain the final medicinal liquid.

5. The method for preparing a heat-relieving, swelling-reducing, and pain-relieving plaster according to claim 4, characterized in that, When decocting the original medicinal liquid, add 1200-1500ml of cold water and 800-1000ml of clean water.