Anti-allergic rhinitis composition as well as preparation method and application thereof

Abstract

The invention discloses an anti-allergic rhinitis composition as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical compositions. The invention provides an anti-allergic rhinitis composition which comprises the following components in parts by weight: 3-6 parts of ephedra, 2-6 parts of almond, 2-6 parts of pearl barley, 1-4 parts of notopterygium root, 1-4 parts of agastache rugosus, 1-4 parts of rhizoma atractylodis, 1-3 parts of radix saposhnikoviae, 1-3 parts of radix angelicae, 1-3 parts of folium mori and 1-3 parts of radix puerariae. The traditional Chinese medicine aromatherapy is prepared from the traditional Chinese medicine composition, and the natural essential oil components in the aromatherapy reduce the local high reaction state of nasal mucosa by adjusting an immunological system, so that the effect of resisting allergic rhinitis is achieved. The invention provides a safe, efficient and convenient anti-allergic rhinitis treatment scheme, obviously improves the defects in the prior art, provides a safe, efficient and easy-to-use treatment choice for allergic rhinitis patients, and has wide application prospect and market value.

Description

Technical Field

[0001] The present invention belongs to the technical field of pharmaceutical compositions, and in particular relates to an anti-allergic rhinitis composition and a preparation method and application thereof. Background Art

[0002] Allergic rhinitis is a common chronic disease, mainly manifested by symptoms such as nasal itching, sneezing, runny nose and nasal congestion. Traditional treatments for allergic rhinitis mainly include oral antihistamines, nasal hormone sprays and immunotherapy. However, these methods have certain limitations, such as oral medications may cause side effects, nasal sprays require long-term use and have limited effects, and immunotherapy is expensive and has a long treatment cycle. Therefore, there is an urgent need to develop a new treatment for allergic rhinitis that is safe, efficient and easy to use.

[0003] The treatment methods for allergic rhinitis in the prior art have the following main problems: (1) Drug side effects: Although oral antihistamines and nasal hormone sprays are effective, long-term use may cause side effects such as drowsiness, dry mouth, nasal mucosal atrophy, etc., and are not suitable for long-term use; (2) High treatment cost: Although immunotherapy has significant effects, it is expensive and has a long treatment cycle, which is not suitable for most patients, especially those with limited financial conditions; (3) Inconvenience in use: The above-mentioned drugs and treatment methods require patients to use them every day, which brings inconvenience to daily life; (4) Limited effect: Many patients are not satisfied with the effects of existing drugs and treatment methods, and the degree of symptom relief is not enough, and the problem of allergic rhinitis cannot be completely solved. Aromatherapy containing plant essential oils, as a traditional aromatherapy, has been widely used to relieve stress and improve sleep. However, there are currently no aromatherapy products specifically for allergic rhinitis on the market. Therefore, it is of great practical significance to develop an aromatherapy composition that can effectively relieve the symptoms of allergic rhinitis. Summary of the invention

[0004] To solve the above technical problems, the present invention proposes an anti-allergic rhinitis composition and its preparation method and application. The anti-allergic rhinitis aromatherapy composition of the present invention can eliminate allergic symptoms by using an aromatherapy composition made of natural ingredients and is suitable for long-term use.

[0005] The present invention provides the following technical solutions:

[0006] Technical solution 1: An anti-allergic rhinitis composition, comprising the following components in parts by weight: 3-6 parts of ephedra, 2-6 parts of apricot kernel, 2-6 parts of coix seeds, 1-4 parts of notopterygium root, 1-4 parts of patchouli, 1-4 parts of atractylodes, 1-3 parts of siler, 1-3 parts of angelica dahurica, 1-3 parts of mulberry leaves and 1-3 parts of kudzu root.

[0007] Furthermore, the following components are included in parts by weight: 5 parts of ephedra, 5 parts of apricot kernel, 5 parts of coix seeds, 3 parts of notopterygium root, 2 parts of patchouli, 3 parts of atractylodes, 2 parts of siler, 2 parts of angelica dahurica, 2 parts of mulberry leaves and 1 part of kudzu root.

[0008] Technical Solution 2: An aromatherapy for treating allergic rhinitis, wherein the active ingredient comprises the anti-allergic rhinitis composition.

[0009] Technical Solution 3: A method for preparing the aromatherapy, comprising the following steps: mixing the components in the anti-allergic rhinitis composition and then crushing them to obtain a mixed composition, adding distilled water for distillation, extracting the oily substance in the aqueous phase of the distillate with anhydrous petroleum ether, and then concentrating the solvent to obtain essential oil, and preparing the essential oil into the aromatherapy.

[0010] Furthermore, the particle size of the mixed composition is 50 meshes.

[0011] Furthermore, the volume ratio of the mixed composition to distilled water is 1:3.

[0012] Technical Solution 4: Use of the anti-allergic rhinitis composition in the preparation of aromatherapy for treating allergic rhinitis.

[0013] Compared with the prior art, the present invention has the following advantages and technical effects:

[0014] The composition of the present invention uses essential oils extracted from natural plants, avoids the side effects of chemical drugs, and is suitable for long-term use. Compared with immunotherapy, the aromatherapy composition of the present invention has low production cost and is easy for patients to accept. In addition, the aromatherapy composition is easy to use, does not require complicated operations, and can be used anytime and anywhere, thereby improving the quality of life of patients. The scientific ratio of a variety of natural ingredients can significantly alleviate the symptoms of allergic rhinitis and provide lasting therapeutic effects. The present invention utilizes a Chinese medicine composition to prepare a Chinese medicine aromatherapy, and the natural essential oil components in the aromatherapy play an anti-allergic rhinitis effect by regulating the immune system and reducing the local high-reaction state of the nasal mucosa. The present invention provides a safe, efficient and convenient anti-allergic rhinitis treatment scheme, which significantly improves the deficiencies of the prior art, and provides a safe, efficient and easy-to-use treatment option for patients with allergic rhinitis, and has broad application prospects and market value. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0016] Figure 1The pharmacological effects of anti-allergic rhinitis aromatherapy in each treatment group on nose scratching in the mouse allergic rhinitis model;

[0017] Figure 2 Pharmacological effect of anti-allergic rhinitis aromatherapy on sneezing in the mouse allergic rhinitis model in each treatment group. DETAILED DESCRIPTION

[0018] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as limiting the present invention, but should be understood as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0019] It should be understood that the terms described in the present invention are only for describing special embodiments and are not intended to limit the present invention. In addition, for the numerical range in the present invention, it should be understood that each intermediate value between the upper and lower limits of the scope is also specifically disclosed. Each smaller range between the intermediate value in any stated value or stated range and any other stated value or intermediate value in the described range is also included in the present invention. The upper and lower limits of these smaller ranges can be independently included or excluded in the scope.

[0020] Unless otherwise indicated, all technical and scientific terms used herein have the same meanings as those generally understood by those skilled in the art. Although the present invention describes only preferred methods and materials, any methods and materials similar or equivalent to those described herein may also be used in the implementation or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials associated with the documents. In the event of a conflict with any incorporated document, the content of this specification shall prevail.

[0021] It will be apparent to those skilled in the art that various modifications and variations may be made to the specific embodiments of the present invention description without departing from the scope or spirit of the present invention. Other embodiments derived from the present invention description will be apparent to those skilled in the art. The present invention description and examples are exemplary only.

[0022] The words “include,” “including,” “have,” “contain,” etc. used in this document are open-ended terms, meaning including but not limited to.

[0023] Example 1

[0024] An anti-allergic rhinitis composition is prepared from the following materials in parts by weight: 5 parts of ephedra, 5 parts of apricot kernel, 4 parts of coix seeds, 3 parts of notopterygium root, 2 parts of patchouli, 3 parts of atractylodes, 2 parts of siler, 2 parts of angelica dahurica, 2 parts of mulberry leaves and 1 part of kudzu root.

[0025] The preparation method of the anti-allergic rhinitis aromatherapy comprises the following steps: washing and drying the medicinal materials in the anti-allergic rhinitis composition according to the proportion, mixing them, crushing them through a 50-mesh sieve to obtain a mixed composition, adding distilled water, the volume ratio of the mixed composition to the distilled water is 1:3, using a steam distillation method, and distilling for 6 hours; extracting the oily substance in the aqueous phase of the distillate with anhydrous petroleum ether, and then concentrating the solvent with a vacuum rotary evaporator to obtain essential oil, and preparing the essential oil as aromatherapy. The preparation method of preparing the essential oil as aromatherapy is: adding the essential oil to the melted wax, stirring evenly, pouring it into a mold to cool and solidify, and when the candle is lit, the essential oil will be released as the candle burns.

[0026] Example 2

[0027] An anti-allergic rhinitis composition is prepared from the following materials in parts by weight: 3 parts of ephedra, 2 parts of apricot kernel, 2 parts of coix seeds, 1 part of notopterygium root, 2 parts of patchouli, 1 part of atractylodes, 1 part of siler, 1 part of angelica root, 1 part of mulberry leaf and 1 part of kudzu root.

[0028] The preparation method of anti-allergic rhinitis aromatherapy comprises the following steps: according to the proportion, the medicinal materials in the anti-allergic rhinitis composition are washed, dried and then mixed, crushed and passed through a 50-mesh sieve to obtain a mixed composition, distilled water is added, the volume ratio of the mixed composition to distilled water is 1:3, and steam distillation is performed for 6 hours; the oily substance in the aqueous phase of the distillate is extracted with anhydrous petroleum ether, and the solvent is concentrated with a vacuum rotary evaporator to obtain essential oil. The preparation method of the essential oil as aromatherapy is as follows: the essential oil is added to the melted wax, the mixture is stirred evenly, poured into a mold, cooled and solidified, and when the candle is lit, the essential oil will be released as the candle burns.

[0029] Example 3

[0030] An anti-allergic rhinitis composition is prepared from the following materials in parts by weight: 6 parts of ephedra, 6 parts of apricot kernel, 6 parts of coix seeds, 4 parts of notopterygium root, 4 parts of patchouli, 3 parts of atractylodes, 3 parts of siler, 2 parts of angelica dahurica, 3 parts of mulberry leaf and 2 parts of kudzu root.

[0031] The preparation method of anti-allergic rhinitis aromatherapy comprises the following steps: according to the proportion, the medicinal materials in the anti-allergic rhinitis composition are washed, dried and then mixed, crushed and passed through a 50-mesh sieve to obtain a mixed composition, distilled water is added, the volume ratio of the mixed composition to distilled water is 1:3, and steam distillation is performed for 6 hours; the oily substance in the aqueous phase of the distillate is extracted with anhydrous petroleum ether, and the solvent is concentrated with a vacuum rotary evaporator to obtain essential oil. The preparation method of the essential oil as aromatherapy is as follows: the essential oil is added to the melted wax, the mixture is stirred evenly, poured into a mold, cooled and solidified, and when the candle is lit, the essential oil will be released as the candle burns.

[0032] Comparative Example 1

[0033] The difference from Example 1 is that the anti-allergic rhinitis composition is made of the following substances in parts by weight: 8 parts of ephedra, 8 parts of apricot kernel, 8 parts of coix seeds, 5 parts of notopterygium root, 6 parts of patchouli, 6 parts of atractylodes, 4 parts of siler, 5 parts of angelica root, 4 parts of mulberry leaf and 4 parts of kudzu root.

[0034] Comparative Example 2

[0035] The difference from Example 1 is that the ephedra and apricot kernel in the anti-allergic rhinitis composition are replaced by cassia twig and perilla seed, respectively. The anti-allergic rhinitis composition is made of the following substances in parts by weight: 5 parts of cassia twig, 5 parts of perilla seed, 4 parts of coix seeds, 3 parts of notopterygium root, 2 parts of patchouli, 3 parts of atractylodes, 2 parts of siler, 2 parts of angelica root, 2 parts of mulberry leaf and 1 part of kudzu root.

[0036] Comparative Example 3

[0037] The difference from Example 1 is that the anti-allergic rhinitis composition does not contain ephedra. The anti-allergic rhinitis composition is made of the following substances in parts by weight: 5 parts of almonds, 4 parts of coix seeds, 3 parts of notopterygium root, 2 parts of patchouli, 3 parts of atractylodes, 2 parts of siler, 2 parts of angelica root, 2 parts of mulberry leaves and 1 part of kudzu root.

[0038] Experimental example:

[0039] Pharmacodynamics test for allergic rhinitis

[0040] (1) Establishment of allergic rhinitis mouse model: SPF male C57BL / 6 mice aged 6-8 weeks, weighing 18-20 g, were selected and raised in a sterile environment at 20-25°C and a relative humidity of 40-60% for 1 week. On days 0, 7, and 14, 100 μg of ovalbumin + 2 mg of aluminum hydroxide dissolved in 0.1 ml of normal saline were intraperitoneally injected daily (basal sensitization). On days 21-28, 500 μg of ovalbumin dissolved in 10 μL of normal saline was dripped into the nose daily, 10 μl in each nostril (intranasal challenge).

[0041] (2) 42 mice were selected from the mice in step (1) and divided into 7 groups according to the random number table method, with 6 mice in each group. Starting from the 7th day after the successful modeling, the mice in each group were first inhaled into the nasal cavity by aromatherapy (wherein, the mice in the experimental group (groups 1-3 of mice) were treated with the anti-allergic rhinitis aromatherapy of Examples 1-3 of the present invention, recorded as Examples 1-3; the mice in the control group (groups 4-6) were treated with the anti-allergic rhinitis aromatherapy of Comparative Examples 1-3 of the present invention, recorded as Comparative Examples 1-3, and the mice in group 7 were given aromatherapy treatment without adding essential oils, recorded as the blank group), and then local antigen stimulation was performed (500 μg of ovalbumin dissolved in 10 μL of normal saline was dripped into the nose, 10 μL each time), and the average number of nose scratching and sneezing of the mice in each group was observed and recorded 30 minutes after the nose drip. The experimental results are as follows: Figure 1 and Figure 2 shown.

[0042] Figure 1 and Figure 2 The results show that the aromatherapy prepared by the anti-allergic rhinitis composition of Examples 1-3 of the present invention has a significant effect on relieving nasal itching and sneezing. Furthermore, no irritation of the anti-allergic rhinitis composition aromatherapy of the present invention to the nasal mucosa of mice was observed, and no local side effects or other systemic side effects of mice were observed.

[0043] The embodiments described above are only descriptions of the preferred modes of the present invention, and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by ordinary technicians in this field should all fall within the protection scope determined by the claims of the present invention.

Claims

1. An anti-allergic rhinitis composition, characterized in that: The composition includes the following components by weight: 3-6 parts of ephedra, 2-6 parts of apricot kernel, 2-6 parts of coix seeds, 1-4 parts of notopterygium root, 1-4 parts of patchouli, 1-4 parts of atractylodes, 1-3 parts of siler, 1-3 parts of angelica root, 1-3 parts of mulberry leaf and 1-3 parts of kudzu root.

2. The anti-allergic rhinitis composition according to claim 1, characterized in that: The invention comprises the following components by weight: 5 parts of ephedra, 5 parts of apricot kernel, 5 parts of coix seeds, 3 parts of notopterygium root, 2 parts of patchouli, 3 parts of atractylodes, 2 parts of siler, 2 parts of angelica dahurica, 2 parts of mulberry leaf and 1 part of kudzu root.

3. An aromatherapy for allergic rhinitis, characterized in that: The active ingredient comprises the anti-allergic rhinitis composition according to claim 1 or 2.

4. A method for preparing aromatherapy according to claim 3, characterized in that: The following steps are involved: The components in the anti-allergic rhinitis composition are mixed and crushed to obtain a mixed composition, distilled water is added for distillation, the oily substance in the aqueous phase of the distillate is extracted with anhydrous petroleum ether, and the solvent is concentrated to obtain essential oil, and the essential oil is prepared as the aromatherapy.

5. The preparation method according to claim 4, characterized in that: The particle size of the mixed composition is 50 mesh.

6. The preparation method according to claim 4, characterized in that: The volume ratio of the mixed composition to distilled water is 1:

3.

7. Use of the anti-allergic rhinitis composition according to claim 1 or 2 in the preparation of aromatherapy for treating allergic rhinitis.

Images