Cognitive competence evaluation method, device and system based on hemodynamics simulation in low oxygen partial pressure environment

Abstract

The invention provides a cognitive competence evaluation method, device and system based on hemodynamics simulation in a low oxygen partial pressure environment. Comprising the following steps: acquiring first brain function connection data, second brain function connection data, first behavioral data, fifth brain function connection data and sixth brain function connection data of a subject under a first oxygen partial pressure condition; acquiring third brain function connection data, fourth brain function connection data, second behavioral data, seventh brain function connection data and eighth brain function connection data of the subject under a second oxygen partial pressure condition, and obtaining a resting state brain function connection evaluation result, a task state brain function connection evaluation result and a behavioral evaluation result; and obtaining a cognitive ability evaluation result based on the resting state brain function connection evaluation result, the task state brain function connection evaluation result and the behavioral evaluation result. Therefore, the adaptive capacity of the subject to the plateau can be accurately evaluated.

Description

Technical Field

[0001] The present application relates to the technical field of cognitive assessment, and in particular to a method, device and system for assessing cognitive ability in a low oxygen partial pressure environment based on hemodynamic simulation. Background Art

[0002] Working memory is a memory system with limited energy that temporarily processes and stores information. It plays an important role in many complex cognitive activities. Working memory involves the storage and operation of short-term information. It is the basis of learning, reasoning and decision-making. It plays an important role in attention control, task switching and interference suppression.

[0003] Low oxygen partial pressure refers to a situation where the oxygen content in the environment is lower than that in the normal environment (horizontal plane). It is common in high-altitude environments and certain special medical conditions (such as cardiopulmonary diseases). Oxygen is an important guarantee for brain function. Low oxygen partial pressure can impair cognitive function, thereby affecting behavioral performance, such as prolonged reaction time and reduced accuracy in the N-back task. In high-altitude environments and aerospace medicine, personnel are often exposed to low oxygen partial pressure. By studying the effects of hypoxia on cognitive function, training and protection strategies can be provided for personnel in these fields to ensure that they can still perform tasks effectively in low oxygen environments. However, there are currently few studies on the effects of low oxygen partial pressure environments on cognitive function, and there is no accurate and reliable method to evaluate cognitive ability in low oxygen partial pressure environments. Summary of the invention

[0004] This application is proposed to solve the above technical problems in the prior art. This application aims to provide a method, device and system for evaluating cognitive ability in a low oxygen partial pressure environment based on hemodynamic simulation, which can accurately evaluate the cognitive ability of subjects in a low oxygen partial pressure environment, and the evaluation results are accurate and reliable.

[0005] According to the first scheme of the present application, a method for evaluating cognitive ability in a hemodynamically simulated low oxygen partial pressure environment is provided, the method comprising: obtaining, via a processor, first brain function connection data within a first brain area of ​​interest when a subject performs a resting-state task in a 2-back task test under a first oxygen partial pressure condition, and second brain function connection data between the first brain area of ​​interest and a second brain area of ​​interest; as well as first behavioral data when performing the test task, and fifth brain function connection data within the first brain area of ​​interest, and sixth brain function connection data between the first brain area of ​​interest and the second brain area of ​​interest; obtaining third brain function connection data of the first brain area of ​​interest, fourth brain function connection data between the first brain area of ​​interest and the second brain area of ​​interest when the subject performs a resting-state task in a 2-back task test under a second oxygen partial pressure condition less than a preset oxygen partial pressure. connection data; and the second behavioral data when performing the test task, and the seventh brain function connection data within the first brain area of ​​interest, and the eighth brain function connection data between the first brain area of ​​interest and the second brain area of ​​interest; based on the first brain function connection data, the second brain function connection data, the third brain function connection data and the fourth brain function connection data, obtain the resting state brain function connection evaluation result; based on the fifth brain function connection data, the sixth brain function connection data, the seventh brain function connection data and the eighth brain function connection data, obtain the task state brain function connection evaluation result; based on the first behavioral data and the second behavioral data, obtain the behavioral evaluation result; based on the resting state brain function connection evaluation result, the task state brain function connection evaluation result and the behavioral evaluation result, obtain the cognitive ability evaluation result for evaluating the cognitive ability of the subjects in a low oxygen partial pressure environment.

[0006] According to the second scheme of the present application, a device for evaluating cognitive ability in an environment of low oxygen partial pressure simulated by hemodynamics is provided, the device comprising a processor, and the processor executes the method for evaluating cognitive ability in an environment of low oxygen partial pressure simulated by hemodynamics as described in the various embodiments of the present application.

[0007] According to the third scheme of the present application, a system for evaluating cognitive ability in an environment of low oxygen partial pressure based on hemodynamic simulation is provided, and the system includes the device for evaluating cognitive ability in an environment of low oxygen partial pressure based on hemodynamic simulation as described in each embodiment of the present application.

[0008] Compared with the prior art, the beneficial effects of the embodiments of the present application are:

[0009] The cognitive ability evaluation method based on hemodynamic simulation of low oxygen partial pressure environment provided in the embodiment of the present application obtains the brain function connection data of the first concerned brain area when the subject performs the resting task and the test task, as well as the brain function connection data between the first concerned brain area and the second concerned brain area, and behavioral data, and respectively determines the resting brain function connection evaluation results, task state brain function connection evaluation results and behavioral evaluation results. By comprehensively considering the resting brain function connection evaluation results, task state brain function connection evaluation results and behavioral evaluation results, the cognitive ability evaluation results are obtained. By comprehensively considering the behavioral data and hemodynamic data of the subject in the process of performing the 2-back task test, the obtained cognitive ability evaluation results have high accuracy and reliability. The cognitive ability evaluation method provided in the embodiment of the present application can be used to evaluate the cognitive ability level of the subject in a low oxygen partial pressure environment, and the evaluation results are accurate and reliable.

[0010] The above description is only an overview of the technical solution of the present application. In order to more clearly understand the technical means of the present application, it can be implemented in accordance with the contents of the specification. In order to make the above description and other purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are listed below. BRIEF DESCRIPTION OF THE DRAWINGS

[0011] In the drawings, which are not necessarily drawn to scale, the same reference numerals may describe similar parts in different views. Similar reference numerals with letter suffixes or different letter suffixes may represent different examples of similar components. The accompanying drawings generally illustrate various embodiments by way of example and not by way of limitation, and together with the description and claims, are used to illustrate the disclosed embodiments. Such embodiments are illustrative and exemplary and are not intended to be exhaustive or exclusive embodiments of the present method, apparatus, system, or non-transitory computer-readable medium having instructions for implementing the method.

[0012] Figure 1 A flow chart of a method for evaluating cognitive ability in a low oxygen partial pressure environment based on hemodynamic simulation according to an embodiment of the present application is shown.

[0013] Figure 2 The behavioral results according to the embodiments of the present application are shown.

[0014] Figure 3 The whole-brain functional connection results according to an embodiment of the present application are shown.

[0015] Figure 4 The results of brain functional connectivity and behavioral correlation according to an embodiment of the present application are shown.

[0016] Figure 5Another result of the correlation between brain functional connectivity and behavior according to an embodiment of the present application is shown.

[0017] Figure 6 Another result of the correlation between brain functional connectivity and behavior according to an embodiment of the present application is shown. DETAILED DESCRIPTION

[0018] In order to enable those skilled in the art to better understand the technical solution of the present application, the present application is described in detail below in conjunction with the accompanying drawings and specific implementation examples. The embodiments of the present application are further described in detail below in conjunction with the accompanying drawings and specific implementation examples, but are not intended to limit the present application.

[0019] The words "first", "second" and similar words used in this application do not indicate any order, quantity or importance, but are only used to distinguish. The words "include" or "comprises" and similar words used in this application mean that the elements before the word include the elements listed after the word, and do not exclude the possibility of covering other elements. In this application, the arrows shown in the figures of each step are only examples of the execution order, not limitations. The technical solution of this application is not limited to the execution order described in the embodiments. The various steps in the execution order can be combined, decomposed, or the order can be changed, as long as the logical relationship of the execution content is not affected.

[0020] All terms (including technical terms or scientific terms) used in this application have the same meaning as those understood by ordinary technicians in the field to which this application belongs, unless otherwise specifically defined. It should also be understood that terms defined in general dictionaries should be interpreted as having a meaning consistent with their meaning in the context of the relevant technology, and should not be interpreted in an idealized or extremely formal sense, unless explicitly defined here. Techniques and equipment known to ordinary technicians in the relevant field may not be discussed in detail, but where appropriate, the techniques and equipment should be considered as part of the specification.

[0021] Figure 1A flowchart of a method for evaluating cognitive ability based on hemodynamic simulation of low oxygen partial pressure environment according to an embodiment of the present application is shown. Steps S101-S107 are executed by a processor. In step S101, the subject is subjected to a 2-back task test under a first oxygen partial pressure condition. During the resting task, the first brain function connection data in the first concerned brain area, the second brain function connection data between the first concerned brain area and the second concerned brain area are obtained; and the first behavioral data when performing the test task, and the fifth brain function connection data in the first concerned brain area, and the sixth brain function connection data between the first concerned brain area and the second concerned brain area. Among them, the oxygen partial pressure depends on the altitude and the atmospheric pressure. As the altitude increases, the atmospheric pressure decreases, and the oxygen partial pressure will also decrease accordingly. At sea level, under standard atmospheric pressure (about 101.3kPa or 760mmHg), the partial pressure of oxygen is about 21kPa or 160mmHg. In high altitude areas, due to the low atmospheric pressure, the partial pressure of oxygen is also reduced accordingly, which has an important impact on the physiological adaptability and health status of the human body.

[0022] Specifically, in this embodiment, the first oxygen partial pressure can be 18-25 kPa, preferably 21 kPa. The subject can adjust the oxygen partial pressure in the simulated oxygen chamber by adjusting the parameters in the simulated oxygen chamber. The 2-back task is a commonly used tool in cognitive psychology for assessing working memory and attention control ability. In this task, the subject needs to judge whether the current stimulus is the same as the previous two stimuli in the current sequence based on the previously presented stimulus sequence. This task requires the subject to maintain information in short-term memory and compare it with previous information when processing new information, thereby testing the capacity and flexibility of their working memory.

[0023] A near-infrared data acquisition device can be used to acquire relevant data, so as to obtain the hemodynamic data of the subject during the 2-back task test based on the collected near-infrared signals, wherein the near-infrared data acquisition device has at least a head cap, which is used to be worn on the subject's head. For example, the head cap can have multiple probes for transmitting and / or receiving near-infrared signals to collect near-infrared signals of multiple corresponding channels. For another example, the head cap can have multiple mounting positions for detachably assembling each probe, and when in use, the probe can be assembled to the head cap through the mounting position. Each of the multiple probes can be configured as a transmitting probe or a receiving probe, and each pair of probes arranged in pairs forms a channel.

[0024] Before performing the 2-back task test, the subject can wear a head cap to obtain the subject's hemodynamic data during the 2-back task test based on the collected near-infrared data. The hemodynamic data includes the concentration changes of oxyhemoglobin, deoxyhemoglobin and total hemoglobin under different oxygen partial pressure conditions and brain functional connections between different brain regions. Among them, the relevant data of brain functional connectivity can be obtained according to the methods disclosed in the prior art. For example, the calculation method of brain functional connectivity can refer to the paper "L. Chan, WC Ung, LG Lim, C.-K. Lu, M. Kiguchi and TBTang,"Automated Thresholding Method for fNIRS-Based Functional Connectivity Analysis: Validation With a Case Study on Alzheimer's Disease," in IEEE Transactions on Neural Systems and Rehabilitation Engineering, vol. 28, no. 8, pp. 1691-1701, Aug. 2020, doi: 10.1109 / TNSRE.2020.3007589.", which will not be repeated here.

[0025] Specifically, the 2-back task can include a resting state and a test task. During the resting state task, the subject needs to keep the body still as much as possible, empty the mind, and look at the center of the screen. During the test task, the subject is shown pictures, each picture is presented for 2.5 seconds, and there is a 2-second interval between pictures, and the interval is presented as "+". The subject needs to judge whether the picture on the current screen is exactly the same as the second picture before. There are 50 pictures in total, and the subject needs to judge 50 times.

[0026] This is only an exemplary description and does not constitute a specific limitation of the 2-back task.

[0027] A near-infrared data acquisition device can be used to collect near-infrared signals of subjects when performing resting tasks and near-infrared signals when performing test tasks, and the change in blood oxygen protein concentration can be obtained based on the scattering and absorption characteristics of the collected near-infrared signals in the tissue, and the change in blood oxygen protein concentration can reflect the neural activity of the brain area. By preprocessing the collected near-infrared raw data and performing correlation analysis on the near-infrared signals of each pair of detection channels, it can be used to evaluate the level of brain functional connectivity within the brain area or between different brain areas. This is only an exemplary description and does not constitute a limitation on the specific scheme.

[0028] In this embodiment, the first brain function connection data in the first brain area of ​​interest and the second brain function connection data between the first brain area of ​​interest and the second brain area of ​​interest are obtained according to the near infrared signal collected by the near infrared data acquisition device when performing the resting state task. Wherein, the first brain area of ​​interest is the left frontal lobe, and the second brain area of ​​interest is the parietal lobe. The present application finds that the brain function connection in the left frontal lobe and the brain function connection between the left frontal lobe and the parietal lobe have an effect on the change of cognitive ability of the subject under low oxygen partial pressure conditions.

[0029] When the subject performs the test task, it is necessary to obtain the first behavioral data of the subject when performing the test task, such as accuracy, reaction time, etc. At the same time, it is also necessary to collect the fifth brain function connection data within the first brain area of ​​interest and the sixth brain function connection data between the first brain area of ​​interest and the second brain area of ​​interest when the subject performs the test task.

[0030] In step S102, the third brain function connection data of the first brain area of ​​interest and the fourth brain function connection data between the first brain area of ​​interest and the second brain area of ​​interest are obtained during the 2-back task test of the subject under the second oxygen partial pressure condition less than the preset oxygen partial pressure; as well as the second behavioral data when performing the test task, and the seventh brain function connection data in the first brain area of ​​interest, and the eighth brain function connection data between the first brain area of ​​interest and the second brain area of ​​interest. Among them, the preset oxygen partial pressure is 15kPa, which is not limited to this, and the second oxygen partial pressure can be 9-14kPa. For example, after collecting the near-infrared data of the subject performing the 2-back task test under the first oxygen partial pressure condition, the oxygen partial pressure in the oxygen chamber is reduced at a rate not exceeding 0.011kPa until the oxygen partial pressure is reduced to the second oxygen partial pressure, so that the physiological condition of the subject remains stable.

[0031] When the oxygen partial pressure in the oxygen chamber is under the second oxygen partial pressure condition, the subject continues to perform the same 2-back task test, and continues to use the near-infrared data acquisition device to collect the near-infrared data of the subject when performing the 2-back task test under the second oxygen partial pressure condition, so as to obtain the third brain functional connection data, the fourth brain functional connection data, the seventh brain functional connection data and the eighth brain functional connection data based on the collected near-infrared data. At the same time, the second behavioral data of the subject when performing the 2-back task test under the second oxygen partial pressure condition is counted.

[0032] In step S103, based on the first brain function connection data, the second brain function connection data, the third brain function connection data and the fourth brain function connection data, a resting state brain function connection evaluation result is obtained, and the resting state brain function connection evaluation result can be used to reflect the impact of the low oxygen partial pressure environment on the brain function connection level of the subject when he is in a resting state.

[0033] In step S104, based on the fifth brain function connection data, the sixth brain function connection data, the seventh brain function connection data and the eighth brain function connection data, a task-state brain function connection evaluation result is obtained, and the task-state brain function connection evaluation result can be used to reflect the impact of the low oxygen partial pressure environment on the brain function connection level of the subject when the subject is in a test task state.

[0034] In step S105, a behavioral evaluation result is obtained based on the first behavioral data and the second behavioral data. The behavioral evaluation result can be used to reflect the impact of the low oxygen partial pressure environment on the behavioral level of the subject.

[0035] In a specific embodiment, subjects with a correct rate of 40% in cognitive tasks were screened, and their demographic information was recorded and included in the group, wherein the inclusion conditions of the subjects were: aged between 18 and 30, right-handed, free of neurological or mental illness, cardiovascular disease, regular work and rest, and no psychostimulant drugs or functional beverages such as coffee and tea were taken 6 hours before the experiment. The demographic information including the name, gender, age and educational background of the participants was recorded, and a total of 81 subjects were finally included.

[0036] Prepare oxygen partial pressure reduction rate error not exceeding 0.011 kPa / s.

[0037] First, at 21.29 kPa, the first 2back task test was conducted to record the average reaction time and average accuracy of the subjects. During the test task, the near-infrared data acquisition device will synchronously collect near-infrared data from the prefrontal and parietal regions of the subjects.

[0038] The specific process of the 2back task includes a 3-minute resting state and a 50-trial 2back task. During the 3-minute resting state, the subject needs to keep the body as still as possible, empty the mind, and look at the center of the screen. During the test task, each picture is presented for 2.5 seconds, and the interval between pictures is 2 seconds, and the interval is presented as "+". The subject needs to judge whether the picture on the current screen is exactly the same as the second picture before. If the picture is consistent, press "1", and if the picture is inconsistent, press "2". There are 50 pictures in total, and the subject needs to judge 50 times.

[0039] The collection device of the near-infrared data acquisition equipment is configured as follows: the frontal lobe has 10 light sources and 5 detectors, forming a total of 17 channels; the parietal lobe has 10 light sources and 6 detectors, forming a total of 20 channels, the distance between adjacent probes is 3 cm, and the coverage depth is 2-3 cm.

[0040] After the first 2back task test, low oxygen partial pressure conditions were simulated by uniformly reducing the oxygen content in the oxygen chamber until it reached 12.91 kPa. Then a second 2back task test was conducted to record the subjects' average reaction time and average accuracy. During the task test, near-infrared data acquisition equipment was used to synchronously collect near-infrared data from the subjects' prefrontal and parietal regions.

[0041] The 2back task data and cerebral blood flow data of the subjects who were enrolled and performed normally under low oxygen pressure environment will be used to calculate the cognitive evaluation under low oxygen pressure. The results are as follows Figure 2-Figure 6 shown.

[0042] Figure 2 The results showed that after entering the low oxygen partial pressure environment, the reaction time of the 2back task decreased (high oxygen partial pressure: 1.39±0.24, low oxygen partial pressure: 1.17±0.28, p<0.01), and the accuracy rate increased (high oxygen partial pressure: 0.83±0.14, low oxygen partial pressure: 0.91±0.10, p<0.01), indicating that the subjects were autonomously adjusting their adaptability to the low oxygen partial pressure environment.

[0043] Figure 3 The results showed that after entering the low oxygen partial pressure environment, the subjects' resting-state whole-brain functional connectivity decreased (high oxygen partial pressure: 0.72±0.18, low oxygen partial pressure: 0.65±0.19, p=0.02), and the task-state whole-brain functional connectivity decreased (high oxygen partial pressure: 0.73±0.24, low oxygen partial pressure: 0.67±0.21, p=0.07), indicating that the low oxygen partial pressure environment has an impact on cognitive function.

[0044] Figure 4 The results showed that under low oxygen pressure conditions, the accuracy of the 2back task was significantly correlated with the brain functional connectivity between the left frontal lobe FL-FL and the left frontal lobe and left parietal lobe FL-PL in the task state. This suggests that the low oxygen pressure environment may affect the connectivity between these brain areas, thereby affecting the subjects' performance in cognitive tasks.

[0045] Figure 5The results showed that the brain functional connectivity of resting FL-FL and resting FL-PL was significantly correlated with the accuracy of the 2back task under high oxygen partial pressure and low oxygen partial pressure conditions, respectively. However, it is worth noting that the correlation coefficients between these brain functional connections and the accuracy decreased when transitioning from high oxygen partial pressure conditions to low oxygen partial pressure conditions. This suggests that low oxygen partial pressure may weaken the connection strength between these brain regions, thereby affecting the accuracy of cognitive tasks.

[0046] Figure 6 The results showed that the change in reaction time of the 2back task was significantly correlated with the change in task-state FL-FL and resting-state FL-PL, further emphasizing the important role of functional connectivity of these brain regions in regulating cognitive performance.

[0047] In step S106, based on the resting state brain function connection evaluation results, task state brain function connection evaluation results and behavioral evaluation results, a cognitive ability evaluation result for evaluating the cognitive ability of the subject in a low oxygen partial pressure environment is obtained. In some other embodiments, the cognitive ability evaluation result can be compared with an evaluation threshold. When the deviation between the cognitive ability evaluation result and the evaluation threshold is less than a preset value, it means that the cognitive ability of the subject in a low oxygen partial pressure environment meets the preset requirements. For example, when the evaluation threshold is 0.6, when the value of the cognitive ability evaluation result is greater than 0.6, that is, when the deviation between the cognitive ability evaluation result and the evaluation threshold is less than 0.4, it is considered that the subject has a higher cognitive ability in a low oxygen partial pressure environment and has a stronger ability to adapt to the plateau.

[0048] The cognitive ability evaluation result may be a total evaluation score, and the score range is in the interval (0, 1). When the cognitive ability evaluation result approaches 1, it is considered that the subject has a higher cognitive ability under a low oxygen partial pressure environment.

[0049] In this way, by integrating the resting-state brain functional connectivity evaluation results, task-state brain functional connectivity evaluation results and behavioral evaluation results, it is possible to obtain a cognitive ability evaluation result that is accurate in evaluating the cognitive ability of subjects in a low oxygen partial pressure environment. The cognitive ability of subjects in a low oxygen partial pressure environment can be evaluated based on the cognitive ability evaluation result with high credibility and accuracy.

[0050] This embodiment can evaluate the cognitive ability of the brain under different oxygen conditions by studying the 2-back task performance of the subjects under different oxygen partial pressures. This is of great significance for understanding how the brain maintains cognitive functions in extreme environments, as well as cognitive assessments in special work scenarios, and even providing timely protection or remedial measures. This embodiment uses a simulated hypoxia chamber to achieve precise control of the single factor of oxygen partial pressure, providing conditions for evaluating the specific impact of oxygen partial pressure on cognition.

[0051] In the present application, the arrows shown in the figures of each step are merely examples of the execution order, not limitations. The technical solution of the present application is not limited to the execution order described in the embodiments. The various steps in the execution order can be combined for execution, can be decomposed for execution, and can be reordered, as long as the logical relationship of the execution content is not affected.

[0052] In some embodiments of the present application, based on the third brain function connection data and the first brain function connection data, a first difference of brain function connection in the first brain area of ​​interest at the second oxygen partial pressure and the first oxygen partial pressure when performing a resting task is obtained; based on the fourth brain function connection data and the second brain function connection data, a second difference of brain function connection between the first brain area of ​​interest and the second brain area of ​​interest at the second oxygen partial pressure and the first oxygen partial pressure when performing a resting task is obtained; based on the first difference and the second difference, the resting brain function connection evaluation result is obtained. Based on the first difference, it can be reflected that the subject enters the second oxygen partial pressure environment from the first oxygen partial pressure and the brain function connection changes in the first brain area of ​​interest when performing a resting task. For example, as the oxygen partial pressure decreases, the brain function connection in the first brain area of ​​interest under the second oxygen partial pressure condition decreases. Similarly, based on the second difference, it can be reflected that the decrease in oxygen partial pressure changes the brain function connection level between the first brain area of ​​interest and the second brain area of ​​interest when the subject is in a resting state. By comprehensively considering the first difference and the second difference, the evaluation result of the low oxygen environment for the brain function connection level can be accurately obtained.

[0053] Specifically, the resting state brain functional connectivity evaluation result can be calculated according to formula (1), which is as follows:

[0054]

[0055] Among them, FL is the first brain region of interest, PL is the second brain region of interest, FL-FL is the first brain functional connection data within the first brain region of interest, and FL-PL is the second brain functional connection data between the first brain region of interest and the second brain region of interest;

[0056] S FC _rest is the evaluation result of resting-state brain functional connectivity;

[0057] Δrest FL-FL represents the first difference, Δrest FL-PL Represents the second difference.

[0058] In this embodiment, the first brain area of ​​interest is the left frontal lobe, and the second brain area of ​​interest is the left parietal lobe. The present application found that under the second oxygen partial pressure condition, the accuracy of performing the 2-back task was significantly correlated with the brain functional connectivity within the left frontal lobe and between the left frontal lobe and the left parietal lobe. The resting state brain functional connectivity evaluation result is calculated based on formula (1), which can accurately reflect the effect of the low oxygen partial pressure environment on the brain functional connectivity of the left frontal lobe and the left parietal lobe of the brain, so as to affect the performance of the cognitive ability of the subject.

[0059] Specifically, Δrest FL-FL =FCrest_L FL-FL -FCrest_H FL-FL , FC represents brain functional connectivity, FCrest_L FL-FL Represents the third brain functional connectivity data, FCrest_H FL-FL Represents the first brain functional connection data. Δrest FL-PL =FCrest_L FL-PL -FCrest_H FL-PL , FCrest_L FL-PL Represents the fourth brain functional connectivity data, FCrest_H FL-PL Represents the second brain functional connectivity data.

[0060] In some embodiments of the present application, based on the seventh brain function connection data and the fifth brain function connection data, a third difference in brain function connections within the first brain area of ​​interest at the second oxygen partial pressure and the first oxygen partial pressure when performing the test task is obtained; based on the eighth brain function connection data and the sixth brain function connection data, a fourth difference in brain function connections between the first brain area of ​​interest and the second brain area of ​​interest at the second oxygen partial pressure and the first oxygen partial pressure when performing the test task is obtained; based on the third difference and the fourth difference, a task-state brain function connection evaluation result is obtained.

[0061] Based on the third difference, it can be reflected that the changes in brain functional connectivity within the first brain region of interest when the subject enters the second oxygen partial pressure environment from the first oxygen partial pressure environment and performs the test task. For example, as the oxygen partial pressure decreases, the brain functional connectivity within the first brain region of interest in the task state under the second oxygen partial pressure condition decreases. Similarly, based on the fourth difference, it can be reflected that the decrease in oxygen partial pressure changes the level of brain functional connectivity between the first brain region of interest and the second brain region of interest when the subject is in the task state.

[0062] Specifically, the evaluation result of the brain functional connectivity in the task state is calculated according to formula (2), which is as follows:

[0063]

[0064] Among them, S FC_2back It represents the evaluation results of brain functional connectivity in task state;

[0065] Δ2back FL-FL Indicates the third difference, Δ2back FL-PL Represents the fourth difference.

[0066] Specifically, Δ2back FL-FL =FC2back_L FL-FL -FC2back_H FL-FL , where FC2back represents the brain functional connectivity in task state, FC2back_L FL-FL Represents the seventh brain functional connectivity data, FC2back_H FL-FL In this embodiment, the Δ2back FL-PL =FC2back_L FL-PL -FC2back_H FL-PL , where FC2back represents the brain functional connectivity in task state, FC2back_L FL-PL Represents the eighth brain functional connectivity data, FC2back_H FL-PL Represents the sixth brain functional connectivity data.

[0067] In some embodiments of the present application, the first behavioral data includes a first accuracy representative value and a first reaction time representative value when performing a test task under a first oxygen partial pressure condition; the second behavioral data includes a second accuracy representative value and a second reaction time representative value when performing a test task under a second oxygen partial pressure condition. Specifically, the first accuracy representative value and the second accuracy representative value may be the average value or maximum value of the accuracy when the subject performs the test task, or other values, without limitation. The first reaction time representative value may be the average value or maximum value of the reaction time when the subject performs the test task, or other values, without limitation.

[0068] In some embodiments of the present application, based on the second accuracy representative value and the first accuracy representative value, a fifth difference between the second accuracy representative value under the second oxygen partial pressure and the first accuracy representative value under the first oxygen partial pressure when performing the test task is obtained; based on the second reaction time representative value and the first reaction time representative value, a sixth difference between the second reaction time representative value under the second oxygen partial pressure and the first reaction time representative value under the first oxygen partial pressure when performing the test task is obtained; based on the fifth difference and the sixth difference, a behavioral evaluation result is obtained.

[0069] When the first brain area of ​​interest is the left frontal lobe and the second brain area of ​​interest is the left parietal lobe, the present application found that when performing a resting-state task under the first oxygen partial pressure condition and performing a resting-state task under the second oxygen partial pressure condition, the brain functional connectivity within the left frontal lobe and the brain functional connectivity between the left frontal lobe and the left parietal lobe were significantly correlated with the accuracy of performing the 2-back task. Moreover, when transitioning from the first oxygen partial pressure condition to the second oxygen partial pressure condition, the correlation coefficient between brain functional connectivity and accuracy decreased, indicating that low oxygen partial pressure may weaken the strength of brain functional connectivity and affect cognitive ability.

[0070] Moreover, the change in reaction time of the 2-back task was significantly correlated with the change in brain functional connectivity within the left frontal lobe in the task state when performing the test task, and the change in brain functional connectivity between the left frontal lobe and the left parietal lobe in the resting state when performing the resting state task. The behavioral evaluation results provided in this embodiment can be used to reflect the important role of brain functional connectivity of the first brain region of interest and the second brain region of interest in regulating cognitive performance.

[0071] Specifically, the behavioral evaluation result is calculated according to formula (3), which is as follows:

[0072]

[0073] Among them, S behavior Indicates the results of behavioral evaluation;

[0074] ΔACC represents the fifth difference; ΔRT represents the sixth difference. ΔACC=ACC L -ACC H , ACC represents the accuracy representative value of the 2-back task, ACC L Indicates the second accuracy representative value, ACC H Indicates the first accuracy representative value. ΔRT=RT L -RT H , RT represents the representative value of reaction time, RT L Represents the second reaction time representative value, RT H Indicates the representative value of the first reaction time.

[0075] According to formula (4), the cognitive ability evaluation result is obtained. Formula (4) is as follows:

[0076] Stotal=S FC_rest +S FC_2back +S behavior ;

[0077] S total Represents the cognitive ability evaluation score, which can be used as the cognitive ability evaluation result. The score range is in the interval (0,1). When Stotal When the score is close to 1, it can be considered that the subject has a stronger ability to adapt to the plateau. In other words, the cognitive ability evaluation result can be obtained by adding the resting state brain function connection evaluation result, the task state brain function connection evaluation result and the behavioral evaluation result.

[0078] In this way, by combining the results of resting brain functional connectivity evaluation, task-state brain functional connectivity evaluation and behavioral evaluation, we can accurately evaluate the impact of low oxygen partial pressure on the cognitive ability of subjects, which is conducive to understanding the impact of low oxygen partial pressure on cognitive function, especially working memory ability, and helping to formulate coping strategies, such as using oxygen supplementation, cognitive training and other intervention measures to reduce the adverse effects of hypoxia on cognitive function. At the same time, we can better understand the impact of low oxygen partial pressure on cognitive function and provide a scientific basis for cognitive protection measures in high-risk environments.

[0079] In some embodiments of the present application, a device for evaluating cognitive ability in a low oxygen partial pressure environment based on hemodynamic simulation is provided, the device comprising a processor, and the processor is configured to execute the method for evaluating cognitive ability in a low oxygen partial pressure environment based on hemodynamic simulation as described in each embodiment of the present application.

[0080] In some embodiments of the present application, a system for evaluating cognitive ability in an environment of low oxygen partial pressure based on hemodynamic simulation is provided, and the system includes the device for evaluating cognitive ability in an environment of low oxygen partial pressure based on hemodynamic simulation as described in each embodiment of the present application.

[0081] The processor may be a processing device including one or more general-purpose processing devices, such as a microprocessor, a central processing unit (CPU), etc. More specifically, the processor may be a complex instruction set computing (CISC) microprocessor, a reduced instruction set computing (RISC) microprocessor, a very long instruction word (VLIW) microprocessor, a processor running other instruction sets, or a processor running a combination of instruction sets. The processor may also be one or more special-purpose processing devices, such as an application-specific integrated circuit (ASIC), a field programmable gate array (FPGA), a digital signal processor (DSP), a system on a chip (SoC), etc.

[0082] This application describes various operations or functions that may be implemented as software codes or instructions or defined as software codes or instructions. Such content may be source code or differential code ("incremental" or "patch" code) that can be directly executed ("object" or "executable" form). Software codes or instructions may be stored in a computer-readable storage medium, and when executed, may cause a machine to perform the described functions or operations, and include any mechanism for storing information in a form accessible to a machine (e.g., a computing device, an electronic system, etc.), such as recordable or non-recordable media (e.g., read-only memory (ROM), random access memory (RAM), magnetic disk storage media, optical storage media, flash memory devices, etc.).

[0083] The exemplary methods described in this application may be implemented at least in part by a machine or computer. In some embodiments, a computer-readable storage medium stores computer program instructions, which, when executed by a processor, cause the processor to perform the cognitive ability evaluation method based on hemodynamic simulation of low oxygen partial pressure environment as described in various embodiments of this application.

[0084] The implementation of such a method may include software code, such as microcode, assembly language code, high-level language code, etc. Various software programming techniques may be used to create various programs or program modules. For example, a program portion or program module may be designed with or by means of Java, Python, C, C++, assembly language, or any known programming language. One or more of such software portions or modules may be integrated into a computer system and / or a computer-readable medium. Such software code may include computer-readable instructions for executing various methods. The software code may form a part of a computer program product or a computer program module. In addition, in an example, the software code may be tangibly stored on one or more volatile, non-temporary or non-volatile tangible computer-readable media, such as during execution or at other times. Examples of these tangible computer-readable media may include, but are not limited to, hard disks, removable disks, removable optical disks (such as optical disks and digital video disks), cassettes, memory cards or memory sticks, random access memories (RAMs), read-only memories (ROMs), etc.

[0085] In addition, although exemplary embodiments have been described herein, the scope includes any and all embodiments based on the present application with equivalent elements, modifications, omissions, combinations (e.g., various embodiments intersecting schemes), adaptations or changes. The elements in the claims will be interpreted broadly based on the language adopted in the claims, and are not limited to the examples described in this specification or during the implementation of the application, and the examples will be interpreted as non-exclusive. Therefore, this specification and examples are intended to be considered as examples only, and the true scope and spirit are indicated by the claims and the full scope of their equivalents.

[0086] The above description is intended to be illustrative rather than restrictive. For example, the above examples (or one or more of them) can be used in combination with each other. For example, those of ordinary skill in the art can use other embodiments when reading the above description. In addition, in the above-mentioned specific embodiments, various features can be grouped together to simplify the application. This should not be interpreted as an intention that a disclosed feature that does not require protection is necessary for any claim. On the contrary, the subject matter of the present application may be less than all the features of a specific disclosed embodiment. Thus, the claims are incorporated into the specific embodiments as examples or embodiments, wherein each claim is independently used as a separate embodiment, and it is considered that these embodiments can be combined with each other in various combinations or arrangements. The scope of the present application should be determined with reference to the full scope of the equivalent forms of the attached claims and these claims.

[0087] The above embodiments are only exemplary embodiments of the present application and are not intended to limit the present application. The protection scope of the present application is defined by the claims. Those skilled in the art may make various modifications or equivalent substitutions to the present application within the essence and protection scope of the present application, and such modifications or equivalent substitutions shall also be deemed to fall within the protection scope of the present application.

Claims

1. A method for evaluating cognitive ability in a hemodynamically simulated low oxygen partial pressure environment, characterized in that: The method comprises: via a processor, Acquiring first brain functional connectivity data within a first brain region of interest and second brain functional connectivity data between the first brain region of interest and a second brain region of interest when the subject performs a 2-back task test under a first oxygen partial pressure condition and performs a resting-state task; and first behavioral data when performing the test task, and fifth brain functional connectivity data within the first brain area of ​​interest, and sixth brain functional connectivity data between the first brain area of ​​interest and the second brain area of ​​interest; Acquiring third brain functional connectivity data of the first brain region of interest and fourth brain functional connectivity data between the first brain region of interest and the second brain region of interest when the subject performs a 2-back task test under a second oxygen partial pressure condition that is less than a preset oxygen partial pressure; and second behavioral data when performing the test task, and seventh brain functional connection data within the first brain area of ​​interest, and eighth brain functional connection data between the first brain area of ​​interest and the second brain area of ​​interest; Based on the first brain function connection data, the second brain function connection data, the third brain function connection data and the fourth brain function connection data, obtaining a resting-state brain function connection evaluation result; Based on the fifth brain function connection data, the sixth brain function connection data, the seventh brain function connection data and the eighth brain function connection data, obtaining a task-state brain function connection evaluation result; Obtaining a behavioral evaluation result based on the first behavioral data and the second behavioral data; Based on the resting-state brain functional connectivity evaluation results, task-state brain functional connectivity evaluation results and behavioral evaluation results, a cognitive ability evaluation result for evaluating the cognitive ability of the subject in a low oxygen partial pressure environment is obtained.

2. The cognitive ability evaluation method according to claim 1, characterized in that: The cognitive ability evaluation method further includes: comparing the cognitive ability evaluation result with an evaluation threshold, and when the deviation between the cognitive ability evaluation result and the evaluation threshold is less than a preset value, it indicates that the cognitive ability of the subject in a low oxygen partial pressure environment meets the preset requirements.

3. The cognitive ability evaluation method according to claim 1, characterized in that: Methods for obtaining resting-state brain functional connectivity evaluation results include: Based on the third brain function connection data and the first brain function connection data, a first difference value of brain function connection in a first brain region of interest at a second oxygen partial pressure and a first oxygen partial pressure when performing a resting-state task is obtained; Based on the fourth brain function connection data and the second brain function connection data, obtaining a second difference in brain function connection between the first brain region of interest and the second brain region of interest at the second oxygen partial pressure and the first oxygen partial pressure when performing a resting-state task; Based on the first difference and the second difference, the resting-state brain functional connectivity evaluation result is obtained.

4. The cognitive ability evaluation method according to claim 3, characterized in that: The resting state brain functional connectivity evaluation result is calculated according to formula (1), which is as follows: Among them, FL is the first brain region of interest, PL is the second brain region of interest, FL-FL is the first brain functional connection data within the first brain region of interest, and FL-PL is the second brain functional connection data between the first brain region of interest and the second brain region of interest; S FC _rest is the evaluation result of resting-state brain functional connectivity; Δrest FL-FL represents the first difference, Δrest FL-PL Represents the second difference.

5. The cognitive ability evaluation method according to claim 1, characterized in that: The evaluation results of task-state brain functional connectivity include: Based on the seventh brain function connection data and the fifth brain function connection data, a third difference value of brain function connection in the first brain area of ​​interest at the second oxygen partial pressure and the first oxygen partial pressure when performing the test task is obtained; Based on the eighth brain function connection data and the sixth brain function connection data, a fourth difference value of brain function connection between the first brain region of interest and the second brain region of interest at the second oxygen partial pressure and the first oxygen partial pressure when performing the test task is obtained; Based on the third difference and the fourth difference, a task-state brain functional connectivity evaluation result is obtained.

6. The cognitive ability evaluation method according to claim 5, characterized in that: The evaluation result of brain functional connectivity in task state is calculated according to formula (2), which is as follows: Among them, S FC_2back It represents the evaluation results of brain functional connectivity in task state; Δ2back FL-FL Indicates the third difference, Δ2back FL-PL Represents the fourth difference.

7. The cognitive ability evaluation method according to claim 1, characterized in that: The behavioral evaluation results include: Based on the second accuracy representative value and the first accuracy representative value, obtaining a fifth difference between the second accuracy representative value under the second oxygen partial pressure and the first accuracy representative value under the first oxygen partial pressure when performing the test task; Based on the second reaction time representative value and the first reaction time representative value, obtaining a sixth difference between the second reaction time representative value under the second oxygen partial pressure and the first reaction time representative value under the first oxygen partial pressure when executing the test task; Based on the fifth difference and the sixth difference, The behavioral evaluation results are calculated according to formula (3), which is as follows: Among them, S behavior Indicates the results of behavioral evaluation; ΔACC represents the fifth difference; ΔRT represents the sixth difference.

8. The cognitive ability evaluation method according to claim 1, characterized in that: The first brain region of interest is the left frontal lobe, and the second brain region of interest is the parietal lobe; The cognitive ability evaluation result can be obtained by adding the resting state brain function connection evaluation result, the task state brain function connection evaluation result and the behavioral evaluation result.

9. A device for evaluating cognitive ability in a low oxygen partial pressure environment based on hemodynamic simulation, characterized in that: The device includes a processor, which executes the cognitive ability evaluation method based on hemodynamic simulation of low oxygen partial pressure environment as described in any one of claims 1-8.

10. A system for evaluating cognitive ability in a low oxygen partial pressure environment based on hemodynamic simulation, characterized in that: The system includes the device for evaluating cognitive ability in a low oxygen partial pressure environment based on hemodynamic simulation as described in claim 9.

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