A cryosurgical apparatus, a cryosurgical method and a cryosurgical instrument

Abstract

The application discloses a refrigeration device, a refrigeration method and a refrigeration surgical instrument, wherein the refrigeration device comprises a refrigeration head, an evaporation piece and a liquid storage assembly, the evaporation piece is connected with the refrigeration head, the evaporation piece is provided with a containing groove for containing refrigeration liquid, and the refrigeration liquid in the containing groove can volatilize to reduce the temperature of the evaporation piece and the refrigeration head; the refrigeration head is provided with a capillary tube, the capillary tube is communicated with the containing groove, part of the refrigeration liquid in the containing groove is transported to the refrigeration head through the capillary tube, the refrigeration liquid transported to the refrigeration head can volatilize to absorb heat, the temperature of the refrigeration head is further reduced, the refrigeration head can still stably maintain the expected temperature requirement when the surrounding environment has a higher temperature, the operation difficulty is reduced, and time and energy are saved.

Description

Technical Field

[0001] This invention relates to the field of medical surgical instruments, and in particular to a cryotherapy device, a cryotherapy method, and a cryosurgery instrument. Background Technology

[0002] In some tasks that require localized low-temperature treatment of a specific interface, such as in the treatment of frostbite within a 1mm diameter area of ​​an animal's skull, it is necessary to maintain the animal's overall normal body temperature while simultaneously maintaining a stable -100°C temperature in a small area of ​​the skull to induce localized frostbite. Therefore, a cryotherapy device is required.

[0003] In existing techniques, a 1mm diameter copper rod is typically immersed in liquid nitrogen for a period of time to reach -100°C. The rod is then removed and placed on the surface of an animal's skull at room temperature for 2 seconds to create a localized frostbite model. However, the surface temperature of the copper rod continues to rise after being removed from the liquid nitrogen and brought to room temperature. Actual measurements show that it takes approximately 12 seconds for the 1mm diameter copper rod to reach -100°C after being removed from the liquid nitrogen, after which the temperature is no longer below -100°C. Furthermore, the copper rod gains more heat from contact with the skull surface, causing it to heat up rapidly, which may prevent the skull surface from reaching -100°C. Due to these significant drawbacks, the freezing process often requires rapid operation, which increases the risk of errors and results in poor localized frostbite treatment.

[0004] Therefore, existing technologies need to be improved and developed. Summary of the Invention

[0005] In view of the above-mentioned deficiencies of the prior art, the purpose of the present invention is to provide a cryotherapy device, cryotherapy method and cryosurgery instrument to solve the technical problem that existing cryoprobes cannot maintain low temperature for a long time.

[0006] The technical solution adopted by the present invention to solve the above problems is as follows:

[0007] A freezing device, comprising: a freezing head, wherein a capillary tube is disposed on the freezing head;

[0008] An evaporator is connected to the freezing head. The evaporator is provided with a receiving tank for holding the refrigerant. The capillary tube is connected to the receiving tank and is used to transport the refrigerant in the receiving tank to the freezing head.

[0009] A liquid storage assembly has an internal storage chamber for containing coolant, the storage chamber being connected to the receiving tank for supplying coolant to the receiving tank.

[0010] Optionally, multiple capillaries are provided, one end of which is connected to the receiving groove, and the other end of which extends to the end of the freezing head away from the evaporator.

[0011] Optionally, the evaporator is cylindrical, and the receiving groove is located on the upper end face of the evaporator. The receiving groove is a cylindrical groove with an opening at the top. The side wall of the evaporator is provided with a connection port that communicates with the receiving groove. The capillary tube communicates with the receiving groove through the connection port, and the liquid storage component communicates with the receiving groove through the upper opening of the receiving groove.

[0012] Optionally, the freezing device further includes a positioning element connected to the evaporator.

[0013] Optionally, the liquid storage assembly includes a coolant guide pipe, a coolant storage bottle, and a flow control device. The coolant storage bottle contains the storage cavity. One end of the coolant guide pipe is connected to the storage cavity, and the other end is connected to the inlet of the flow control device. The outlet of the flow control device is connected to the receiving tank.

[0014] Optionally, the coolant guide tube may include a flexible coolant guide tube.

[0015] Optionally, the refrigerant storage bottle includes an insulated inner bottle and an insulated heat insulation layer, the insulated heat insulation layer being disposed on the outer surface of the insulated inner bottle; and / or, the refrigerant guide tube includes a guide inner tube and a guide heat insulation layer, the guide heat insulation layer being disposed on the outer surface of the guide inner tube.

[0016] Optionally, the refrigeration device further includes a handle disposed on the liquid storage assembly.

[0017] A freezing method for a freezing apparatus as described in any of the preceding claims, characterized by comprising the steps of:

[0018] Move the freezing head to the desired freezing position and secure it.

[0019] The coolant in the liquid storage assembly is transferred to the evaporator until the level of the coolant in the evaporator is above the connection between the capillary tube and the receiving tank.

[0020] A cryosurgery instrument, wherein the cryosurgery instrument includes a cryo-device as described in any of the preceding claims.

[0021] In summary, the beneficial effects of this invention are:

[0022] The refrigeration device of the present invention includes a freezing head, an evaporator, and a liquid storage assembly. The evaporator is connected to the freezing head and has a receiving tank for holding the refrigerant. The refrigerant in the receiving tank evaporates, reducing the temperature of the evaporator and the freezing head. A capillary tube is provided on the freezing head and communicates with the receiving tank, so that a portion of the refrigerant in the receiving tank is transported to the freezing head through the capillary tube. The refrigerant transported to the freezing head evaporates and absorbs heat, further reducing the temperature of the freezing head. This enables the freezing head to stably maintain the expected temperature even when the ambient temperature is high, reducing the difficulty of operation and saving time and effort. Attached Figure Description

[0023] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0024] Figure 1 This is a schematic diagram of the structure of the refrigeration device of the present invention;

[0025] Figure 2 This is a cross-sectional view of the refrigeration apparatus of the present invention;

[0026] Figure 3 This is a cross-sectional view of the freezing head in this invention;

[0027] Figure 4 This is a flowchart of the freezing method in this invention.

[0028] The components are as follows: 100, freezing head; 110, capillary tube; 200, evaporator; 400, liquid storage assembly; 410, coolant guide tube; 411, inner guide tube; 412, guide insulation layer; 420, coolant storage bottle; 421, inner insulated bottle; 422, insulation layer; 430, flow control device; 431, liquid inlet nozzle; 432, flow control switch; 500, handle; 600, positioning component. Detailed Implementation

[0029] To enable those skilled in the art to better understand the present invention, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, other embodiments obtained by those skilled in the art without creative effort are all within the scope of protection of the present invention.

[0030] Please see Figure 1 and Figure 3 In one embodiment of the present invention, a refrigeration device is disclosed, including a freezing head 100, an evaporator 200, and a liquid storage assembly 400. The freezing head 100 is provided with a capillary tube 110; the evaporator 200 is connected to the freezing head 100 and is provided with a receiving tank for holding refrigerant; the capillary tube 110 is disposed on the freezing head 100, and one end of the capillary tube 110 communicates with the receiving tank for transporting a portion of the refrigerant in the receiving tank to the freezing head 100; the liquid storage assembly 400 has a storage cavity inside for holding refrigerant, and the storage cavity communicates with the receiving tank for supplying refrigerant to the receiving tank.

[0031] In this embodiment, the coolant is liquid nitrogen, which has a boiling point of -196°C and can rapidly vaporize under normal pressure. During the vaporization process, liquid nitrogen absorbs a large amount of heat, thereby reducing the ambient temperature.

[0032] Specifically, the liquid storage component 400 stores liquid nitrogen. When the cryogenic head 100 needs to maintain a low temperature, the operator tilts the liquid storage component 400, allowing the liquid nitrogen inside to enter the receiving tank on the evaporator 200. The liquid nitrogen entering the receiving tank rapidly vaporizes, absorbing a large amount of heat during the vaporization process, thereby reducing the temperature of the evaporator 200. Since the cryogenic head 100 is connected to the evaporator 200, its temperature also decreases accordingly. It should be emphasized that because the cryogenic head 100 is equipped with a capillary tube 110, and the inlet of the capillary tube 110 is connected to the receiving tank, when the liquid nitrogen in the liquid storage component 400 enters the receiving tank, the capillary tube 110 comes into contact with the liquid nitrogen. According to the principle of capillary action, the capillary tube 110 transports the liquid nitrogen from the receiving tank to the cryogenic head 100. The liquid nitrogen transported to the cryogenic head 100 vaporizes and absorbs heat, further reducing the temperature of the cryogenic head 100.

[0033] The capillary principle in this embodiment refers to the fact that a liquid surface is similar to a stretched rubber membrane; if the liquid surface is curved, it tends to flatten. Therefore, a concave liquid surface exerts a pulling force on the liquid below, and a convex liquid surface exerts a pressure on the liquid below. Capillary action is caused by surface tension. The liquid surface in the capillary tube 110 is concave, which exerts a pulling force on the liquid below, causing the liquid to rise along the tube wall. When the upward pulling force equals the weight of the liquid column inside the tube, the liquid stops rising and reaches equilibrium. For example, water rises in a thin glass tube because it wets glass.

[0034] In this embodiment, by setting up an evaporator 200, the temperature of the freezing head 100 is reduced by utilizing the principle of liquid nitrogen vaporization and heat absorption. By setting up a capillary tube 110, liquid nitrogen is transported to the freezing head 100 for vaporization and heat absorption using the capillary principle, which further reduces the temperature of the freezing head 100 and extends the time that the freezing head 100 maintains a low temperature. This reduces the difficulty of freezing operations, saves time and effort, and enables the freezing head 100 to stably maintain the expected temperature even when the surrounding temperature is high.

[0035] Please see Figure 2 Multiple capillary tubes 110 are provided. One end of the capillary tube 110 is connected to the receiving groove, and the other end of the capillary tube 110 extends to the end of the freezing head 100 away from the evaporator 200.

[0036] In this embodiment, one or more capillary tubes 110 can be provided, and the number of capillary tubes 110 can be determined according to the amount of refrigerant to be delivered. There are several ways to install the capillary tubes 110 on the freezing head 100. For example, one or more channels can be opened at intervals inside the freezing head 100, and then the capillary tubes 110 can be installed in each of the channels; alternatively, fine holes can be directly opened inside the freezing head 100, and these fine holes are the capillary tubes 110 described in this embodiment.

[0037] During the freezing operation, the operator places the freezing head 100 into liquid nitrogen for cooling. When the temperature of the freezing head 100 reaches the required temperature, the freezing head 100 is removed and transferred to the surface of the experimental object and left for a certain period of time to create a local frostbite model. During the freezing operation, the end of the freezing head 100 away from the evaporator 200 is the operating end.

[0038] When liquid nitrogen on the evaporator 200 vaporizes and absorbs heat, the cooling effect of the operating end of the freezing head 100 is affected to some extent because the operating end is far from the evaporator 200. Furthermore, when the operating end of the freezing head 100 comes into contact with the object being frozen, the heat from the object is transferred to the operating end of the freezing head 100, causing the temperature of the operating end of the freezing head 100 to rise. In this embodiment, a small amount of liquid nitrogen in the container tank is transported to the operating end of the freezing head 100 through the capillary action of the capillary tube 110. The liquid nitrogen transported to the operating end of the freezing head 100 vaporizes and absorbs heat, reducing the temperature of the operating end of the freezing head 100, thus making the heat exchange and cooling of the freezing head 100 more complete.

[0039] In this embodiment, the evaporator 200 is cylindrical, and the receiving groove is provided on the upper end face of the evaporator 200. The receiving groove is a cylindrical groove with an opening at the top. The side wall of the evaporator 200 is provided with a connection port that communicates with the receiving groove. The capillary tube 110 communicates with the receiving groove through the connection port, and the liquid storage assembly 400 communicates with the receiving groove through the upper opening of the receiving groove.

[0040] Specifically, the end of the capillary tube 110 away from the operating end of the cryogenic head 100 is the liquid inlet end, which is connected to the connection port. When the operator tilts the liquid storage assembly 400, the liquid nitrogen in the liquid storage assembly 400 enters the receiving tank through the upper opening of the receiving tank. When the liquid nitrogen in the receiving tank submerges the liquid inlet end of the capillary tube 110, the liquid nitrogen enters the capillary tube 110 through the liquid inlet end of the capillary tube 110.

[0041] In this embodiment, the evaporator 200 is set as a cylinder, which can make better use of space and reduce the volume of the evaporator 200. An opening is set above the receiving tank, which can release the pressure in the receiving tank and avoid danger due to excessive gas pressure. On the other hand, the opening above the receiving tank allows the operator to observe the amount of liquid nitrogen in the receiving tank, which is convenient for operation.

[0042] In a feasible embodiment, the evaporator 200 is further provided with a side opening that communicates with the receiving tank, and the liquid storage assembly 400 can communicate with the receiving tank through the side opening.

[0043] In this embodiment, the cross-section of the freezing head 100 gradually decreases along the direction away from the evaporator 200.

[0044] In this embodiment, the cross-section of the end of the freezing head 100 closest to the evaporator 200 is set to be larger, ensuring efficient heat transfer between the freezing head 100 and the evaporator 200. Since the operating end of the freezing head 100 needs to contact the object being frozen, it may suffer localized frostbite. To allow for more precise operation, the operating end of the freezing head 100 is usually set to be relatively small to avoid frostbite on areas outside the target area. In this embodiment, the cross-section of the freezing head 100 gradually decreases along the direction away from the evaporator 200, which ensures that the operating end can be designed to be sufficiently small as needed, while also ensuring sufficient heat exchange between the freezing head 100 and the evaporator 200.

[0045] In this embodiment, the freezing head 100 and the evaporator 200 are integrally formed.

[0046] An integral molding structure refers to connecting multiple parts into a whole through a molding process. An integral molding structure can not only improve the strength and rigidity of the structure, but also reduce the number of connecting parts, thereby reducing thermal resistance and obstacles in the heat conduction process, improving heat dissipation efficiency, and extending the low temperature duration of the cryogenic head 100.

[0047] In this embodiment, the freezing head 100 includes a pure copper freezing head 100 or a stainless steel freezing head 100; and / or, the evaporator 200 includes a pure copper evaporator 200 or a stainless steel evaporator 200.

[0048] Specifically, both pure copper and stainless steel have high thermal conductivity, so in the cryohead 100, which requires efficient heat transfer, copper and stainless steel can quickly transfer heat. It should be emphasized that, due to the metallic properties of pure copper, it is easier to process and can be easily made into cryoheads 100 of various shapes and sizes. In addition, pure copper also has excellent antifreeze properties.

[0049] In this embodiment, the freezing device further includes a positioning element 600, which is connected to the evaporator 200.

[0050] Specifically, one end of the positioning member 600 is fixedly connected to the evaporator 200, and the other end extends in a direction away from the evaporator 200, for handheld use or for connection to an external control device. The flow control device 430 is connected to the positioning member 600. Since the freezing head 100 is connected to the evaporator 200, and the evaporator 200 is connected to the positioning member 600, moving the positioning member 600 can move the freezing head 100, allowing it to be positioned in a suitable location. By setting the positioning member 600, the freezing head 100 can be positioned flexibly and accurately.

[0051] To prevent the evaporator 200 from exchanging heat with the outside through the positioning element 600, which could lead to an excessively low temperature in the positioning element 600, the positioning element 600 is made of a material with slow thermal conductivity, such as plastic or other heat-insulating materials.

[0052] In this embodiment, the liquid storage assembly 400 includes a coolant guide pipe 410, a coolant storage bottle 420, and a flow control device 430. The coolant storage bottle 420 has a storage cavity. One end of the coolant guide pipe 410 is connected to the storage cavity, and the other end is connected to the inlet end of the flow control device 430. The outlet end of the flow control device 430 is connected to the receiving tank.

[0053] Please see Figure 2In this embodiment, the flow control device 430 includes a liquid inlet 431 and a flow control switch 432. The liquid inlet 431 is fixedly connected to the positioning member 600, and one end of the liquid inlet 431 is connected to the coolant guide pipe 410, while the other end is aligned with the upper opening of the receiving tank. The flow control switch 432 is located on the liquid inlet 431 and is used to control the flow rate of liquid nitrogen.

[0054] Specifically, when the operator tilts the cryogenic storage bottle 420, the liquid nitrogen in the cryogenic storage bottle 420 enters the liquid inlet 431 through the cryogenic guide pipe 410. By controlling the opening of the flow control switch 432, the flow rate of liquid nitrogen entering the container can be adjusted. The liquid nitrogen flowing through the liquid inlet 431 enters the container from the top opening of the container.

[0055] Because the inner diameter of the cryogenic fluid guide tube 410 is smaller than the inner diameter of the cryogenic fluid storage bottle 420, the operator can easily control the flow rate of liquid nitrogen, thereby better controlling the speed and amount of liquid nitrogen poured out.

[0056] In this embodiment, the refrigerant guide tube 410 includes a flexible refrigerant guide tube, which is made of flexible material and can be bent, making it easy for operators to flexibly position the freezing head and convenient to use.

[0057] Please see Figure 2 The cryogenic storage bottle 420 includes an insulated inner bottle 421 and an insulated heat insulation layer 422, the insulated heat insulation layer 422 being disposed on the outer surface of the insulated inner bottle 421; and / or, the cryogenic guide tube 410 includes a guide inner tube 411 and a guide heat insulation layer 412, the guide heat insulation layer 412 being disposed on the outer surface of the guide inner tube 411.

[0058] Specifically, the inner insulated bottle 421 includes a vacuum insulated tube, which consists of inner and outer containers. The inner layer has a storage cavity inside, and the space between the inner and outer layers is evacuated to a vacuum state, which can effectively reduce heat loss and thus achieve a high-efficiency insulation effect. In this embodiment, a heat insulation layer 422 is also provided outside the vacuum tube, further improving the insulation effect of the refrigerant storage bottle 420. Correspondingly, the inner guide tube 411 also includes a vacuum insulated tube, and a guide heat insulation layer 412 is provided outside the vacuum insulated tube, improving the insulation effect of the refrigerant guide tube 410.

[0059] In this embodiment, the insulated inner bottle 421 and the guide inner tube 411 are integrally formed, as are the thermal insulation layer 422 and the guide insulation layer 412. By making the insulated inner bottle 421 and the guide inner tube 411 an integrally formed structure, not only can the strength and rigidity of the structure be improved, but the number of sealing components can also be reduced, thereby reducing thermal resistance and obstacles in the heat conduction process, improving heat dissipation efficiency, and extending the low-temperature duration of the freezing head 100.

[0060] In this embodiment, the coolant guide pipe 410 is detachably connected to the evaporator 200.

[0061] During the manufacturing process of the frozen model, different objects require different areas to be frozen, so different sizes of freezing heads 100 need to be replaced. In this embodiment, the evaporator 200 and the freezing head 100 are integrally formed. Therefore, when replacing the freezing head 100, the evaporator 200 and the freezing head 100 are removed from the coolant guide pipe 410 and replaced with different models of freezing heads 100 and evaporators 200, making the freezing device more convenient to use and more widely applicable.

[0062] In this embodiment, the freezing device further includes a handle 500, which is disposed on the liquid storage assembly 400.

[0063] The handle 500 can improve the comfort and stability of the liquid storage assembly 400 and make it more convenient for operators during the freezing process. In order to prevent the liquid storage assembly 400 from exchanging heat with the outside through the handle 500, which would cause the temperature of the handle 500 to be too low, the handle 500 is made of a material with slow thermal conductivity, such as a wooden stick or other heat insulation material.

[0064] As another embodiment of this application, please refer to Figure 4 A freezing method is also disclosed for use in the freezing apparatus described above, comprising the steps of:

[0065] S100. Move the freezing head to the position to be frozen and fix it in place.

[0066] S200, The coolant in the liquid storage assembly is conveyed to the evaporator until the liquid level of the coolant in the evaporator is above the connection port between the capillary tube and the receiving tank.

[0067] Specifically, the steps of moving the freezing head to the position to be frozen and fixing it also include: placing the freezing head in liquid nitrogen until the temperature of the freezing head reaches -100°C and then removing the freezing head.

[0068] In this embodiment, the freezing location is either an attachment to the surface of the object being frozen or in direct contact with the object. In this embodiment, the freezing device can be controlled by an external device or operated manually.

[0069] Since the temperature of the freezing head gradually rises after it is removed from liquid nitrogen, and also rises when it comes into contact with the object being frozen, this embodiment cools the freezing head by supplying the refrigerant from the storage component to the evaporator. The refrigerant in the evaporator vaporizes and absorbs heat. Furthermore, when the level of the refrigerant in the evaporator exceeds the connection port between the capillary tube and the receiving tank, the refrigerant in the receiving tank enters the freezing head through the connection hole. The refrigerant in the freezing head evaporates, further reducing the temperature of the freezing head. This allows the freezing head to maintain a stable temperature that meets the expected requirements even when the ambient temperature is high, reducing operational difficulty and saving time and effort.

[0070] As another embodiment of this application, a cryosurgery instrument is also disclosed, wherein the cryosurgery instrument is provided with a freezing device as described in any of the above. The freezing device stably maintains a small area at -100°C to induce localized frostbite.

[0071] In summary, the refrigeration device of this embodiment includes a freezing head 100, an evaporator 200, and a liquid storage assembly 400. The evaporator 200 is connected to the freezing head 100 and has a container for holding the refrigerant. The refrigerant in the container evaporates, reducing the temperature of the evaporator 200 and the freezing head 100. The freezing head 100 is provided with a capillary tube 110, which is connected to the container. This allows a portion of the refrigerant in the container to be transported to the freezing head 100 via the capillary tube 110 for evaporation and heat absorption, further reducing the temperature of the freezing head 100. This ensures that the freezing head 100 can stably maintain the expected temperature even when the ambient temperature is high, reducing operational difficulty and saving time and effort.

[0072] It should be noted that, unless otherwise specified, the embodiments and features described in this application can be combined with each other.

[0073] It should be noted that this invention uses a freezing device, freezing method, and cryosurgery instrument as examples to introduce the specific structure and working principle of the invention. However, the application of this embodiment is not limited to the freezing device, freezing method, and cryosurgery instrument, and can also be applied to the production and use of other similar workpieces.

[0074] It should be understood that the present invention is not limited to the precise structure described above and shown in the accompanying drawings, and various modifications and changes can be made without departing from its scope. The scope of the invention is limited only by the appended claims.

[0075] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A refrigeration apparatus, characterized in that, include: A freezing head, wherein a capillary tube is provided on the freezing head; An evaporator is connected to the freezing head. The evaporator is provided with a receiving tank for holding the refrigerant. The capillary tube is connected to the receiving tank and is used to transport the refrigerant in the receiving tank to the freezing head. A liquid storage assembly, wherein the liquid storage assembly has an internal storage cavity for containing coolant, the storage cavity being connected to the receiving tank for supplying coolant to the receiving tank; The cross-section of the freezing head gradually decreases along the direction away from the evaporator; The evaporator is cylindrical, and the receiving groove is located on the upper end face of the evaporator. The receiving groove is a cylindrical groove with an opening at the top. The side wall of the evaporator is provided with a connection port that communicates with the receiving groove. The capillary tube communicates with the receiving groove through the connection port, and the liquid storage component communicates with the receiving groove through the upper opening of the receiving groove.

2. The refrigeration apparatus according to claim 1, characterized in that, Multiple capillaries are provided, one end of which is connected to the receiving groove, and the other end of which extends to the end of the freezing head away from the evaporator.

3. The refrigeration apparatus according to claim 1, characterized in that, The refrigeration device also includes a positioning element, which is connected to the evaporation element.

4. The refrigeration apparatus according to claim 1, characterized in that, The liquid storage assembly includes a coolant guide pipe, a coolant storage bottle, and a flow control device. The coolant storage bottle contains the storage cavity. One end of the coolant guide pipe is connected to the storage cavity, and the other end is connected to the inlet of the flow control device. The outlet of the flow control device is connected to the receiving tank.

5. The refrigeration apparatus according to claim 4, characterized in that, The cryogenic fluid guide tube includes a flexible cryogenic fluid guide tube.

6. The refrigeration apparatus according to claim 5, characterized in that, The cryogenic storage bottle includes an insulated inner bottle and an insulated heat insulation layer, the insulated heat insulation layer being disposed on the outer surface of the insulated inner bottle; and / or, the cryogenic guide tube includes a guide inner tube and a guide heat insulation layer, the guide heat insulation layer being disposed on the outer surface of the guide inner tube.

7. The refrigeration apparatus according to claim 1, characterized in that, The refrigeration device also includes a handle, which is disposed on the liquid storage assembly.

8. A cryosurgery instrument, characterized in that, Includes the refrigeration apparatus as described in any one of claims 1 to 7.

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