Glacier deuterium-depleted water eye protection liquid and preparation method thereof

By using glacier low water water and various natural raw materials preparation, the chemical components in existing eye protection fluids may have the side effects of the eye caused by the eyes, and achieve a natural, safe, and effective eye protection effect.

CN119367474APending Publication Date: 2025-01-28肖剑慧
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Patent Information

Application Number
CN202411566308.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-11-05
Publication Date
2025-01-28

AI Technical Summary

Technical Problem

Existing eye protection liquids often contain chemical ingredients, and long-term use may cause side effects on the eyes, and there is a lack of natural, safe and effective eye protection liquids on the market.

Method used

Using glacier low water water as solvents, combined with blueberry extract, honeysuckle extract solution, Cassia seed extraction solution, lutein, hydrolyzed pearl, borosa, borax, nine -nine bamboo roasted salt and other natural raw materials to prepare a natural and safe protection Eye fluid.

Benefits of technology

This eye protection can effectively alleviate symptoms such as eye fatigue, dryness, redness and swelling. It has no side effects for a long time, and it is not easy to produce resistance. It is widely used.

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Abstract

The invention belongs to the technical field of eye protection liquid, and particularly relates to glacier deuterium-depleted water eye protection liquid and a preparation method thereof. The glacier deuterium-depleted water eye protection liquid is prepared from the following raw materials: a blueberry extracting solution, a honeysuckle flower extracting solution, a semen cassiae extracting solution, xanthophyll, hydrolyzed pearl, borneol, borax, nine-process bamboos roasted salt and glacier deuterium-depleted water. The eye protection liquid adopts natural raw materials, is not added with any chemical additive, has the advantages of being natural, safe and free of side effects, can effectively relieve eye fatigue, dryness, redness and swelling and other symptoms, and protects eye health. Long-term use of the eye-protecting liquid does not generate drug resistance, and the eye-protecting liquid is convenient to use and wide in applicable crowd.
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Description

Technical Field

[0001] The invention belongs to the technical field of eye protection liquid, and in particular relates to a glacial low-deuterium water eye protection liquid and a preparation method thereof. Background Art

[0002] With the widespread use of electronic devices and changes in people's lifestyles, problems such as eye fatigue, dryness, and decreased vision are becoming increasingly serious. There are many types of eye drops on the market, but most of them contain chemical ingredients, and long-term use may cause certain side effects to the eyes.

[0003] For example, the patent application with the patent application number: 202411057618.1 discloses a sodium bromfenac eye drop and a preparation method thereof, which is composed of sodium bromfenac, L-malic acid, sodium cyclamate, pH regulator, and water for injection, and may also contain benzalkonium chloride and sodium carboxymethylcellulose. L-malic acid and sodium cyclamate are used as excipients of sodium bromfenac eye drops. While maintaining the stability of sodium bromfenac, the amount of excipients used is greatly reduced compared to the prior art, and there is no need to use more excipients such as antioxidants. In addition, the stability of the obtained sodium bromfenac eye drops is also significantly improved.

[0004] The patent application with patent application number: 202410937839.1 discloses an eye drop and its preparation method and application. The original eye drop material includes: copper ion compound, sodium hyaluronate, epigallocatechin gallate, glycyrrhizic acid, glucose oxidase, pH adjuster and sterilized ultrapure water. The eye drop raw materials use a variety of natural active ingredients, which effectively promote the healing of eye wounds through a variety of mechanisms (including antibacterial, anti-inflammatory, antioxidant and promoting tissue regeneration), breaking through the constraints of traditional antibiotic eye drops that may have poor effects due to drug resistance, and solving the problem of poor efficacy of commonly used clinical treatments for corneal wound infections.

[0005] Therefore, developing a natural, safe and effective eye drop has important practical significance. Summary of the invention

[0006] Based on the above technical background, the main purpose of the present invention is to provide a glacial low-deuterium water eye protection solution and a preparation method thereof to overcome the deficiencies in the prior art.

[0007] In order to achieve the above-mentioned invention object, the technical solution adopted by the present invention includes:

[0008] The first aspect of the present invention is to provide a glacier low-deuterium water eye protection liquid, which comprises the following raw materials in parts by weight: 20 to 30 parts by weight of blueberry extract, 20 to 30 parts by weight of honeysuckle extract, 20 to 30 parts by weight of cassia seed extract, 20 to 30 parts by weight of lutein, 150 to 250 parts by weight of hydrolyzed pearls, 1 to 4 parts by weight of borneol, 0.5 to 2 parts by weight of borax, 550 to 650 parts by weight of nine-processed bamboo roasted salt, and 9000 to 9500 parts by weight of glacier low-deuterium water.

[0009] Preferably, the glacier low-deuterium water eye protection solution comprises the following raw materials in parts by weight: 22 to 27 parts by weight of blueberry extract, 23 to 27 parts by weight of honeysuckle extract, 24 to 27 parts by weight of cassia seed extract, 23 to 27 parts by weight of lutein, 180 to 220 parts by weight of hydrolyzed pearls, 1 to 3 parts by weight of borneol, 0.8 to 1.5 parts by weight of borax, 580 to 610 parts by weight of nine-processed bamboo roasted salt, and 9100 to 9300 parts by weight of glacier low-deuterium water.

[0010] More preferably, the glacier low-deuterium water eye protection solution is composed of the following raw materials in parts by weight: 25 parts by weight of blueberry extract, 25 parts by weight of honeysuckle extract, 25 parts by weight of cassia seed extract, 25 parts by weight of lutein, 200 parts by weight of hydrolyzed pearls, 2 parts by weight of borneol, 1 part by weight of borax, 597 parts by weight of nine-processed bamboo roasted salt, and 9200 parts by weight of glacier low-deuterium water.

[0011] The second aspect of the present invention is to provide a method for preparing the glacier low-deuterium water eye protection solution according to the first aspect of the present invention, the preparation method comprising the following steps:

[0012] Step 1: Place Japanese salt (sea salt) in a bamboo tube and bake it at high temperature to obtain nine-step bamboo-baked salt;

[0013] Step 2: Mix blueberry extract, honeysuckle extract, cassia seed extract, lutein, hydrolyzed pearls, borneol, borax and nine-processed bamboo roasted salt, then add into glacier low-deuterium water and stir to obtain glacier low-deuterium water eye protection solution.

[0014] In step 1,

[0015] Preferably, the high-temperature baking includes 9 baking and calcining, and the procedure of high-temperature baking is: heating to 700-900°C and baking for 1-3h, after cooling, heating to 800-950°C again and baking for 2-4h, after cooling, heating to 850-1000°C and baking for 3-5h, after cooling, heating to 800-1000°C and baking for 1-3h, after cooling, heating to 850-950°C and baking for 1-3h, after cooling, heating to 900-1000°C and baking for 1-3h, after cooling, heating to 850-950°C and baking for 3-5h, after cooling, heating to 800-900°C and baking for 1-3h, after cooling, finally heating to 850-950°C and baking for 2-4h, cooling to room temperature, and the nine-process bamboo baking salt is obtained.

[0016] More preferably, the high-temperature baking procedure is: heat to 800℃ and bake for 2h, after cooling, heat to 850℃ again and bake for 3h, after cooling, heat to 900℃ and bake for 4h, after cooling, heat to 950℃ and bake for 2h, after cooling, heat to 900℃ and bake for 2h, after cooling, heat to 950℃ and bake for 2h, after cooling, heat to 900℃ and bake for 2h, after cooling, heat to 950℃ and bake for 2h, after cooling, heat to 900℃ and bake for 4h, after cooling, heat to 850℃ and bake for 2h, after cooling, finally heat to 900℃ and bake for 3h, cool to room temperature to obtain nine-process bamboo roasted salt.

[0017] In step 2,

[0018] Preferably, blueberry extract, honeysuckle extract, cassia seed extract, lutein, hydrolyzed pearls, borneol, borax and nine-processed bamboo roasted salt are mixed, and then added to glacier low-deuterium water and stirred at 50-150 r / min for 20-45 minutes to obtain glacier low-deuterium water eye protection solution.

[0019] The beneficial effects of the present invention are:

[0020] (1) The glacier low-deuterium water eye drops include the following raw materials: blueberry extract, honeysuckle extract, cassia seed extract, lutein, hydrolyzed pearls, borneol, borax, Wudang Mountain Bamboo Roasted Salt (nine-processed Bamboo Roasted Salt) and glacier low-deuterium water. The blueberry extract in the eye drops is rich in anthocyanins and has the effects of anti-oxidation and retinal protection; the honeysuckle extract has the effects of clearing heat and detoxifying, anti-inflammatory and antibacterial; the cassia seed extract can clear the liver and improve eyesight; lutein can filter blue light and protect the eyes from light damage; the hydrolyzed pearls have the effects of improving eyesight and removing cataracts; borneol has the effects of clearing heat and relieving pain, reducing swelling and relieving itching; borax can clear heat and detoxify, reduce swelling and prevent corrosion; Wudang Mountain Bamboo Roasted Salt contains a variety of minerals and has a certain health care effect on the eyes; the glacier low-deuterium water is pure and pollution-free, has the advantages of inhibiting the growth of cancer cells, promoting human metabolism, increasing human immunity, and protecting human health, and provides a good solvent for eye drops.

[0021] The eye protection liquid of the present invention adopts natural raw materials without the addition of chemical additives, is natural, safe and has no side effects, can effectively relieve symptoms such as eye fatigue, dryness, redness and swelling, better protect eye health, will not produce drug resistance after long-term use, is easy to use, and is suitable for a wide range of people.

[0022] (2) The nine-process bamboo roasted salt of the present invention is made by nine times of high-temperature calcination, which removes impurities in Japanese salt and makes it contain only rich minerals and trace elements, making it safer and more effective to use. DETAILED DESCRIPTION

[0023] The present invention will be described in detail below, and the characteristics and advantages of the present invention will become clearer and more distinct with the description.

[0024] The first aspect of the present invention is to provide a glacier low-deuterium water eye protection liquid, which comprises the following raw materials in parts by weight: 20 to 30 parts by weight of blueberry extract, 20 to 30 parts by weight of honeysuckle extract, 20 to 30 parts by weight of cassia seed extract, 20 to 30 parts by weight of lutein, 150 to 250 parts by weight of hydrolyzed pearls, 1 to 4 parts by weight of borneol, 0.5 to 2 parts by weight of borax, 550 to 650 parts by weight of nine-processed bamboo roasted salt (Wudang Mountain bamboo roasted salt), and 9000 to 9500 parts by weight of glacier low-deuterium water.

[0025] Preferably, the glacier low-deuterium water eye protection solution comprises the following raw materials in parts by weight: 22 to 27 parts by weight of blueberry extract, 23 to 27 parts by weight of honeysuckle extract, 24 to 27 parts by weight of cassia seed extract, 23 to 27 parts by weight of lutein, 180 to 220 parts by weight of hydrolyzed pearls, 1 to 3 parts by weight of borneol, 0.8 to 1.5 parts by weight of borax, 580 to 610 parts by weight of nine-processed bamboo roasted salt (Wudang Mountain bamboo roasted salt), and 9100 to 9300 parts by weight of glacier low-deuterium water.

[0026] More preferably, the glacier low-deuterium water eye protection solution is composed of the following raw materials in parts by weight: 25 parts by weight of blueberry extract, 25 parts by weight of honeysuckle extract, 25 parts by weight of cassia seed extract, 25 parts by weight of lutein, 200 parts by weight of hydrolyzed pearls, 2 parts by weight of borneol, 1 part by weight of borax, 597 parts by weight of nine-processed bamboo roasted salt (Wudang Mountain bamboo roasted salt), and 9200 parts by weight of glacier low-deuterium water.

[0027] The second aspect of the present invention is to provide a method for preparing the glacier low-deuterium water eye protection solution according to the first aspect of the present invention, the preparation method comprising the following steps:

[0028] Step 1, put the Japanese salt in a bamboo tube and bake it at high temperature to obtain the nine-step bamboo-baked salt;

[0029] Step 2: Mix blueberry extract, honeysuckle extract, cassia seed extract, lutein, hydrolyzed pearls, borneol, borax and nine-processed bamboo roasted salt, then add into glacier low-deuterium water and stir to obtain glacier low-deuterium water eye protection solution.

[0030] The above steps are described in detail below.

[0031] In step 1, select bamboo that has grown for more than three years, put the daily salt into the bamboo tube, seal it with pure selenium-rich loess below 4 meters, and then put it into the calciner for high-temperature baking.

[0032] The high-temperature baking includes 9 baking and calcining, and the procedure of the high-temperature baking is: heating to 700-900°C for baking for 1-3 hours, cooling down, heating again to 800-950°C for baking for 2-4 hours, cooling down, heating to 850-1000°C for baking for 3-5 hours, cooling down, heating to 800-1000°C for baking for 1-3 hours, cooling down, heating to 850-950°C for baking for 1-3 hours, cooling down, heating to 900-1000°C for baking for 1-3 hours, cooling down, heating to 850-950°C for baking for 3-5 hours, cooling down, heating to 800-900°C for baking for 1-3 hours, cooling down, finally heating to 850-950°C for baking for 2-4 hours, cooling to room temperature, and obtaining nine-process bamboo baking salt.

[0033] Preferably, the high-temperature baking procedure is: heating to 800°C and baking for 2 hours, after cooling down, heating to 850°C again and baking for 3 hours, after cooling down, heating to 900°C and baking for 4 hours, after cooling down, heating to 950°C and baking for 2 hours, after cooling down, heating to 900°C and baking for 2 hours, after cooling down, heating to 950°C and baking for 2 hours, after cooling down, heating to 900°C and baking for 4 hours, after cooling down, heating to 850°C and baking for 2 hours, after cooling, finally heating to 900°C and baking for 3 hours, cooling to room temperature, and the nine-process bamboo roasted salt is obtained.

[0034] In step 2, blueberry extract, honeysuckle extract, cassia seed extract, lutein, hydrolyzed pearls, borneol, borax and nine-processed bamboo roasted salt are mixed, and then added into glacier low-deuterium water and stirred at 50-150 r / min for 20-45 minutes to obtain glacier low-deuterium water eye protection solution.

[0035] Preferably, the mixture is added into glacial low-deuterium water and stirred at 100 r / min for 30 minutes to obtain glacial low-deuterium water eye protection solution.

[0036] The nine-processed bamboo roasted salt of the present invention is roasted at high temperature for nine times, and is a treasure trove of trace elements, containing a large number of rich minerals and trace elements, such as sodium, calcium, silicon, potassium, magnesium, copper, iron, selenium, etc. In addition, Xinjiang's ten thousand year glacial low deuterium water and hydrogen isotopes are added as a carrier solution. Studies have found that it has the advantages of inhibiting the growth of cancer cells, promoting human metabolism, increasing human immunity, and protecting human health. It can also promote the synthesis of protein, a basic substance of the human body, and ensure the integrity of DNA genetic information.

[0037] The method of using the eye drops is as follows: when using, tilt your head back slightly, gently pull down the lower eyelid with your hand to form a small capsule, drop the eye drops into the capsule, drop 4 to 6 drops each time, then gently close your eyes and rotate your eyeballs to evenly distribute the eye drops on the eye surface. It can be used 4 to 5 times a day, and the specific frequency of use can be adjusted according to personal eye conditions and needs.

[0038] Example

[0039] The present invention is further described below by specific examples, which are limited to illustrating the present invention but not to limiting the scope of the present invention. The raw materials used in the examples of the present invention were all purchased.

[0040] Example 1

[0041] Select bamboo that has grown for more than three years, put the Japanese salt into the bamboo tube, seal it with pure selenium-rich loess below 4 meters, and then put it into the calciner for high-temperature baking. The high-temperature baking includes 9 calcinations, and the procedure of high-temperature baking is: heating to 800℃ and baking for 2 hours, cooling down, heating to 850℃ and baking for 3 hours, cooling down, heating to 900℃ and baking for 4 hours, cooling down, heating to 950℃ and baking for 2 hours, cooling down, heating to 900℃ and baking for 2 hours, cooling down, heating to 950℃ and baking for 2 hours, cooling down, heating to 900℃ and baking for 4 hours, cooling down, heating to 850℃ and baking for 2 hours, cooling down, finally heating to 900℃ and baking for 3 hours, cooling to room temperature, and the nine-system bamboo roasted salt is obtained.

[0042] Weigh 25 parts by weight of blueberry extract, 25 parts by weight of honeysuckle extract, 25 parts by weight of cassia seed extract, 25 parts by weight of lutein, 200 parts by weight of hydrolyzed pearls, 2 parts by weight of borneol, 1 part by weight of borax, 597 parts by weight of nine-processed bamboo roasted salt, and 9200 parts by weight of glacial low-deuterium water.

[0043] The weighed blueberry extract, honeysuckle extract, cassia seed extract, lutein, hydrolyzed pearls, borneol, borax and nine-processed bamboo roasted salt were mixed, and then added into glacier low-deuterium water and stirred at 100 r / min for 30 minutes to obtain glacier low-deuterium water eye protection solution.

[0044] Example 2

[0045] Select bamboo that has grown for more than three years, put the Japanese salt into the bamboo tube, seal it with pure selenium-rich loess below 4 meters, and then put it into the calciner for high-temperature baking. The high-temperature baking includes 9 calcinations, and the procedure of high-temperature baking is: heating to 700℃ for baking for 3 hours, cooling down, heating to 800℃ for baking for 4 hours, cooling down, heating to 850℃ for baking for 3 hours, cooling down, heating to 800℃ for baking for 3 hours, cooling down, heating to 850℃ for baking for 3 hours, cooling down, heating to 900℃ for baking for 3 hours, cooling down, heating to 850℃ for baking for 5 hours, cooling down, heating to 800℃ for baking for 3 hours, cooling down, finally heating to 850℃ for baking for 4 hours, cooling to room temperature, and the nine-system bamboo roasted salt is obtained.

[0046] Weigh 22 parts by weight of blueberry extract, 23 parts by weight of honeysuckle extract, 24 parts by weight of cassia seed extract, 23 parts by weight of lutein, 180 parts by weight of hydrolyzed pearls, 1 part by weight of borneol, 0.8 parts by weight of borax, 580 parts by weight of nine-processed bamboo roasted salt, and 9100 parts by weight of glacial low-deuterium water.

[0047] The weighed blueberry extract, honeysuckle extract, cassia seed extract, lutein, hydrolyzed pearls, borneol, borax and nine-processed bamboo roasted salt were mixed, and then added into glacier low-deuterium water and stirred at 50 r / min for 45 minutes to obtain glacier low-deuterium water eye protection solution.

[0048] Example 3

[0049] Select bamboo that has grown for more than three years, put the Japanese salt into the bamboo tube, seal it with pure selenium-rich loess below 4 meters, and then put it into the calciner for high-temperature baking. The high-temperature baking includes 9 calcinations, and the high-temperature baking procedure is: heating to 900℃ for baking for 1 hour, cooling down, heating to 950℃ for baking for 2 hours, cooling down, heating to 1000℃ for baking for 3 hours, cooling down, heating to 1000℃ for baking for 1 hour, cooling down, heating to 950℃ for baking for 1 hour, cooling down, heating to 1000℃ for baking for 1 hour, cooling down, heating to 950℃ for baking for 3 hours, cooling down, heating to 900℃ for baking for 1 hour, cooling down, finally heating to 950℃ for baking for 2 hours, cooling to room temperature, and the nine-system bamboo roasted salt is obtained.

[0050] Weigh 27 parts by weight of blueberry extract, 27 parts by weight of honeysuckle extract, 27 parts by weight of cassia seed extract, 27 parts by weight of lutein, 220 parts by weight of hydrolyzed pearls, 3 parts by weight of borneol, 1.5 parts by weight of borax, 610 parts by weight of nine-processed bamboo roasted salt, and 9300 parts by weight of glacial low-deuterium water.

[0051] The weighed blueberry extract, honeysuckle extract, cassia seed extract, lutein, hydrolyzed pearls, borneol, borax and nine-processed bamboo roasted salt were mixed, and then added into glacier low-deuterium water and stirred at 150 r / min for 20 min to obtain glacier low-deuterium water eye protection solution.

[0052] The present invention has been described in detail above in conjunction with specific implementations and exemplary examples, but these descriptions cannot be understood as limiting the present invention. Those skilled in the art understand that, without departing from the spirit and scope of the present invention, a variety of equivalent substitutions, modifications or improvements may be made to the technical solution of the present invention and its implementation methods, all of which fall within the scope of the present invention. The scope of protection of the present invention shall be subject to the attached claims.

Claims

1. A glacier deuterium-depleted water eye protection solution, characterized in that: The glacier low-deuterium water eye protection liquid comprises the following raw materials in parts by weight: 20-30 parts by weight of blueberry extract, 20-30 parts by weight of honeysuckle extract, 20-30 parts by weight of cassia seed extract, 20-30 parts by weight of lutein, 150-250 parts by weight of hydrolyzed pearls, 1-4 parts by weight of borneol, 0.5-2 parts by weight of borax, 550-650 parts by weight of nine-processed bamboo roasted salt, and 9000-9500 parts by weight of glacier low-deuterium water.

2. The glacier deuterium-depleted water eye-protecting solution according to claim 1, characterized in that: The glacier low-deuterium water eye protection liquid comprises the following raw materials in parts by weight: 22 to 27 parts by weight of blueberry extract, 23 to 27 parts by weight of honeysuckle extract, 24 to 27 parts by weight of cassia seed extract, 23 to 27 parts by weight of lutein, 180 to 220 parts by weight of hydrolyzed pearls, 1 to 3 parts by weight of borneol, 0.8 to 1.5 parts by weight of borax, 580 to 610 parts by weight of nine-processed bamboo roasted salt, and 9100 to 9300 parts by weight of glacier low-deuterium water.

3. The glacier deuterium-depleted water eye-protecting solution according to claim 2, characterized in that: The glacier low-deuterium water eye protection liquid is composed of the following raw materials in parts by weight: 25 parts by weight of blueberry extract, 25 parts by weight of honeysuckle extract, 25 parts by weight of cassia seed extract, 25 parts by weight of lutein, 200 parts by weight of hydrolyzed pearls, 2 parts by weight of borneol, 1 part by weight of borax, 597 parts by weight of nine-processed bamboo roasted salt, and 9200 parts by weight of glacier low-deuterium water.

4. A method for preparing the glacial deuterium-depleted water eye solution according to any one of claims 1 to 3, characterized in that: The preparation method comprises the following steps: Step 1, put the Japanese salt in a bamboo tube and bake it at high temperature to obtain the nine-step bamboo-baked salt; Step 2: Mix blueberry extract, honeysuckle extract, cassia seed extract, lutein, hydrolyzed pearls, borneol, borax and nine-processed bamboo roasted salt, then add into glacier low-deuterium water and stir to obtain glacier low-deuterium water eye protection solution.

5. The preparation method according to claim 4, characterized in that: In step 1, The high-temperature baking includes 9 baking and calcining, and the procedure of the high-temperature baking is: heating to 700-900°C for baking for 1-3 hours, cooling down, heating again to 800-950°C for baking for 2-4 hours, cooling down, heating to 850-1000°C for baking for 3-5 hours, cooling down, heating to 800-1000°C for baking for 1-3 hours, cooling down, heating to 850-950°C for baking for 1-3 hours, cooling down, heating to 900-1000°C for baking for 1-3 hours, cooling down, heating to 850-950°C for baking for 3-5 hours, cooling down, heating to 800-900°C for baking for 1-3 hours, cooling down, finally heating to 850-950°C for baking for 2-4 hours, cooling to room temperature, and obtaining nine-process bamboo baking salt.

6. The preparation method according to claim 5, characterized in that: The procedure of high-temperature baking is: heat to 800℃ and bake for 2h, after cooling, heat to 850℃ again and bake for 3h, after cooling, heat to 900℃ and bake for 4h, after cooling, heat to 950℃ and bake for 2h, after cooling, heat to 900℃ and bake for 2h, after cooling, heat to 950℃ and bake for 2h, after cooling, heat to 900℃ and bake for 2h, after cooling, heat to 950℃ and bake for 2h, after cooling, heat to 900℃ and bake for 4h, after cooling, heat to 850℃ and bake for 2h, after cooling, finally heat to 900℃ and bake for 3h, cool to room temperature, and the nine-process bamboo roasted salt is obtained.

7. The preparation method according to claim 4, characterized in that: In step 2, Mix blueberry extract, honeysuckle extract, cassia seed extract, lutein, hydrolyzed pearls, borneol, borax and nine-processed bamboo roasted salt, then add into glacier low-deuterium water and stir at 50-150 r / min for 20-45 minutes to obtain glacier low-deuterium water eye protection solution.

Citation Information

Patent Citations

  • Bromfenac sodium eye drops and preparation method thereof

    CN118615245A

  • Eye drops as well as preparation method and application thereof

    CN118649180A