Traditional Chinese medicine composition for hair growth

Abstract

The invention discloses a traditional Chinese medicine composition for hair growth and a preparation and application thereof. The traditional Chinese medicine composition comprises cacumen biotae, pine needles, ginger, radix angelicae, herba lycopi and holy basil. The extraction method comprises the following steps: uniformly mixing the raw materials by using a traditional Chinese medicine grinder, crushing, adding absolute ethyl alcohol, performing ultrasonic treatment for 20 minutes, and performing suction filtration to obtain the traditional Chinese medicine extract. The invention finds and verifies that the traditional Chinese medicine composition and the preparation thereof have the effect of treating alopecia, and can shorten the growth cycle of hair, increase the number of hair follicles and change the form of the hair follicles, thereby achieving the effect of treating alopecia.

Description

Technical Field

[0001] The present invention belongs to the technical field of Chinese medicine compositions, and in particular relates to a Chinese medicine composition for hair growth, a preparation thereof and an application thereof. Background Art

[0002] Normal hair loss of less than 100 hairs per day is considered physiological hair loss and is a normal metabolic phenomenon of the body. Hair loss is a common skin disease in clinical practice. Its incidence rate is increasing year by year. It is difficult to cure and is becoming younger. It is bothering more and more people. Although hair loss will not affect the patient's physical health, it has a serious negative effect on the quality of life and mental health. According to data released by the National Health Commission in 2019, more than 250 million people in China suffer from hair loss, including about 163 million men and about 88 million women. On average, one in every six people is troubled by hair loss.

[0003] Existing hair growth drugs, such as minoxidil tincture and finasteride tablets, can effectively promote hair growth, but may be accompanied by side effects such as dizziness, palpitations and sexual dysfunction. Although hair transplant surgery has long-lasting effects, it is expensive and has a limited scope of application. In contrast, the present invention uses pure natural medicinal materials, has significant safety advantages, and significantly reduces adverse effects on the body. Summary of the invention

[0004] The first object of the present invention is to provide a Chinese medicine composition for hair growth; The second object of the present invention is to provide a preparation of the above-mentioned Chinese medicine composition for hair growth; The third object of the present invention is to provide the use of the above-mentioned traditional Chinese medicine composition for hair growth in the preparation of hair growth medicine.

[0005] In order to achieve the above object, the technical solution adopted by the present invention is: A traditional Chinese medicine composition for hair growth is prepared from the following raw materials in proportion by weight: 15-75 parts of Platycladus orientalis leaves, 10-50 parts of pine needles, 3-15 parts of ginger, 3-15 parts of Angelica dahurica, 3-15 parts of Zedoariae rhizome and 3-15 parts of Tonka cordifolia; the extraction method comprises the following steps: mixing the raw materials, mixing them evenly with a traditional Chinese medicine grinder, and then crushing them, adding anhydrous ethanol, performing ultrasonic treatment for 20 minutes, and filtering to obtain a traditional Chinese medicine extract.

[0006] In order to further realize the present invention, the above-mentioned Chinese medicine composition is made of the following raw materials in the following weight ratio: 60 parts of Platycladus orientalis leaves, 40 parts of pine needles, 12 parts of ginger, 12 parts of Angelica dahurica, 12 parts of Zedoariae rhizome and 12 parts of Tonka cordifolia.

[0007] In order to further realize the present invention, the amount of anhydrous ethanol added is 3 times the total weight of the raw materials.

[0008] A preparation of a traditional Chinese medicine composition for hair growth, characterized in that medically acceptable auxiliary materials are added to the alcohol extract to prepare any one of decoctions, granules, pills, tablets, capsules, ointments, syrups and powders.

[0009] A use of a traditional Chinese medicine composition for hair growth in the preparation of a hair growth medicine.

[0010] Compared with the prior art, the present invention has the following beneficial effects: The hair growth Chinese medicine extract of the present invention can achieve the effects of hair growth, hair loss prevention, oil control and itching relief.

[0011] Platycladus orientalis leaves: bitter in taste, cold in nature, can promote hair growth and darken hair, shorten the process of hair follicles from the resting phase to the growing phase, promote the development of hair follicles, increase the melanin content in the hair follicles, and make the hair black.

[0012] Pine needles: bitter in taste, warm in nature, can dispel wind and dampness, kill insects and relieve itching, strengthen hair roots, make hair strong, relieve scalp itching and improve scalp health.

[0013] Ginger: It tastes spicy and is slightly warm in nature. It stimulates the scalp, speeds up scalp metabolism, promotes local blood circulation, activates atrophic hair follicles, and promotes the regeneration of hair follicles.

[0014] Angelica dahurica: It tastes spicy and is warm in nature. Its drying and moistening properties help reduce oil secretion on the scalp, remove dirt and grease from the hair, keep the hair shiny, inhibit bacteria and fungi on the scalp, and maintain a healthy scalp.

[0015] Ze Lan: It tastes bitter and spicy, is slightly warm in nature, removes blood stasis and promotes new growth, nourishes hair, reduces hair breakage and split ends, improves the health of hair follicles, and promotes hair growth.

[0016] Linglingxiang: It tastes spicy and slightly bitter, is warm in nature, has a strong aroma, can remove filth and turbidity, nourish and moisturize hair, and make hair moisturized and shiny.

[0017] The present invention is based on the compatibility theory of Dunhuang medicine, the basic theory of traditional Chinese medicine, and the premise of syndrome differentiation and treatment. According to the compatibility principles of the four qi and five flavors of the medicine, the rise and fall, the seven emotions and meridians, etc., the Platycladus orientalis leaves, ginger, and pine needles are selected to form a corner medicine, which is ingenious and has the effects of hair growth, hair loss prevention, and hair root strengthening. Among them, Platycladus orientalis leaves are the monarch, ginger and pine needles are the ministers, Platycladus orientalis leaves are hair growth and hair loss prevention, ginger activates hair follicles, and pine needles are used to supplement the shape and strengthen hair. The three Chinese medicines have the same nature and flavor, forming a tripod, and promoting hair growth from different dimensions of scalp, hair follicles, and hair. Angelica dahurica and Zedoariae rhizome are adjuvants. Both are pungent and warm products. The bitter and pungent combination can be used to clear and descend. Angelica dahurica dispels wind and dampness, reduces scalp oil secretion; Zedoariae rhizome dispels blood stasis and promotes newness, improves scalp metabolism, and jointly regulates the local microenvironment of the scalp. Linglingxiang is a fragrant product that avoids filth and turbidity, makes hair moisturized and shiny, and is a guiding medicine. The whole formula can promote hair growth and prevent hair loss, control oil and relieve itching, and nourish the scalp.

[0018] The present invention has discovered and verified that the Chinese medicine composition and the preparation thereof have the efficacy of treating hair loss, can shorten the growth cycle of hair, increase the number of hair follicles, change the morphology of hair follicles, and achieve the effect of treating hair loss.

[0019] The present invention is a hair growth product that combines traditional wisdom with modern needs. It cleverly selects three medicinal materials, Platycladus orientalis leaves, ginger and pine needles, and forms Dunhuang horn medicine through the principle of compatibility of similar materials. Platycladus orientalis leaves are rich in nourishing ingredients, which help to strengthen hair roots; ginger can promote blood circulation in the scalp and activate hair follicles; pine needles help to regulate the scalp environment and reduce hair loss. In addition, Angelica dahurica, Zedoariae rhizome and Tonka are added to enhance the effect synergistically. Angelica dahurica activates hair follicles, provides necessary nutrients for hair, and promotes hair growth; Zedoariae rhizome promotes diuresis and reduces swelling, regulates the endocrine system, and improves the scalp microenvironment; Tonka stimulates the expansion of scalp capillaries, optimizes microcirculation, and creates more favorable conditions for hair growth. The synergistic effect of various drugs not only has a significant effect on hair growth and prevention of hair loss, but also can fundamentally strengthen hair roots and improve hair quality. Compared with other hair growth products, the present invention pays more attention to the combination of nature and health, and nourishes the scalp gently and deeply with pure natural ingredients.

[0020] The present invention not only focuses on hair growth itself, but also uses the transdermal effect of the Chinese medicine composition and its preparation to allow the drug to penetrate into the scalp and then circulate into the human body through blood vessels, thereby regulating the body's qi and blood balance and optimizing the endocrine environment, fundamentally solving the problem of hair loss and providing patients with a more comprehensive and effective hair growth solution. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 This is a picture of hair growth on the back of mice; Figure 2 The hair growth scores of mice at different administration time points were calculated; Figure 3 The relative area of ​​graying of the mouse back skin at different administration time points; Figure 4 It is the time when the mouse back skin turns dark; Figure 5 The hair length on the back of mice after 40 days of drug administration; Figure 6 The pathological tissue sections of the mouse back skin were stained with hematoxylin-eosin to observe the hair follicles. DETAILED DESCRIPTION

[0022] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0023] Embodiment 1: Platycladus orientalis leaves 15g, pine needles 10g, ginger 3g, angelica 3g, zedoaria 3g and tonka bean 3g; After mixing all the raw materials, they were evenly mixed with a traditional Chinese medicine grinder and then crushed, 111 ml of anhydrous ethanol was added, and the hair-growth traditional Chinese medicine extract was ultrasonically treated for 20 minutes, and the traditional Chinese medicine extract was filtered to obtain the traditional Chinese medicine extract.

[0024] Embodiment 2: 30g of Platycladus orientalis leaves, 20g of pine needles, 6g of ginger, 6g of angelica dahurica, 6g of zedoaria, and 6g of tonka betel; After mixing all the raw materials, they were evenly mixed with a traditional Chinese medicine grinder and then crushed, 222 ml of anhydrous ethanol was added, and the hair-growth traditional Chinese medicine extract was ultrasonically treated for 20 minutes, and the traditional Chinese medicine extract was filtered to obtain the traditional Chinese medicine extract.

[0025] Embodiment 3: 45g of Platycladus orientalis leaves, 30g of pine needles, 9g of ginger, 9g of angelica dahurica, 9g of zedoaria, and 9g of tonka bean; After mixing all the raw materials, they were evenly mixed with a traditional Chinese medicine grinder and then crushed, 333 ml of anhydrous ethanol was added, and the hair-growth traditional Chinese medicine extract was ultrasonically treated for 20 minutes, and the traditional Chinese medicine extract was filtered to obtain the traditional Chinese medicine extract.

[0026] Embodiment 4: 60g of Platycladus orientalis leaves, 40g of pine needles, 12g of ginger, 12g of angelica dahurica, 12g of zedoaria, and 12g of tonka bean; After mixing all the raw materials, they were evenly mixed with a traditional Chinese medicine grinder and then crushed, 444 ml of anhydrous ethanol was added, the hair-growth traditional Chinese medicine extract was ultrasonically treated for 20 minutes, and the traditional Chinese medicine extract was filtered to obtain the traditional Chinese medicine extract.

[0027] Embodiment 5: 75g of Platycladus orientalis leaves, 50g of pine needles, 15g of ginger, 15g of angelica dahurica, 15g of zedoaria, and 15g of tonka bean; After mixing all the raw materials, they were evenly mixed with a traditional Chinese medicine grinder and then crushed, 555 ml of anhydrous ethanol was added, the hair-growth traditional Chinese medicine extract was ultrasonically treated for 20 minutes, and the traditional Chinese medicine extract was filtered to obtain the traditional Chinese medicine extract.

[0028] Experimental results: The drug prepared in Example 5 was subjected to animal experimental observation.

[0029] Observation subjects: C57bl / 6 male mice, 4-6 weeks old.

[0030] The mice were randomly divided into a control group and a drug administration group, with 6 mice in each group. The hair was first cut with scissors, and then the hair on both sides of the midline of the back spine of all mice was shaved with an animal shaver to fully expose the skin. The hair of the back area of ​​2cmx 3cm was shaved with a mouse shaver to construct a hair loss model. The control group was not treated in any way. The drug administration group was smeared with 0.2 mL of the Chinese medicine extract of Example 4, and the Chinese medicine group mice were smeared with Chinese medicine twice in the morning and afternoon every day, 60 μl each time. The back skin was cleaned with normal saline before administration to remove the residual drug from the previous time. From the time of depilation to the time when the hair completely covered the back skin, the skin color changes of the mice were observed every day, and photos were taken and recorded regularly.

[0031] like Figure 1 As shown, the hair growth rate in the shaved area of ​​the back skin of mice in the drug-treated group was faster than that in the model group.

[0032] like Figure 2 As shown in the figure, the growth of new hair in the depilatory area of ​​mice was scored, and the scoring criteria were: 1, the new hair in the depilatory area accounted for 0-20% of the total area of ​​the depilatory area; 2, the new hair in the depilatory area accounted for 20-40% of the total area of ​​the depilatory area; 3, the new hair in the depilatory area accounted for 40-60% of the total area of ​​the depilatory area; 4, the new hair in the depilatory area accounted for 60-80% of the total area of ​​the depilatory area; 5, the new hair in the depilatory area accounted for 80-100% of the total area of ​​the depilatory area. Compared with the model group, the growth of hair in the depilatory area on the back of the mice in the drug-treated group was better.

[0033] like Figure 3 As shown, the growth area of ​​new hair in the hair loss area on the back of mice at different administration time points was measured using ImageJ. like Figure 4 As shown, the back skin of mice in the drug-treated group darkened earlier than that in the model group.

[0034] like Figure 5 As shown, at the same time point, the hair on the back of mice in the drug-treated group was longer compared with that in the model group.

[0035] like Figure 6 As shown, compared with the model group, the number of hair follicles in the back skin of mice in the drug-treated group increased.

[0036] As shown in Table 1, compared with the model group, the time for the back skin of mice in the groups treated with Examples 1, 2, 3, and 4 to darken was shortened in a dose-dependent manner, while the effect of the group treated with Example 5 was weakened.

[0037] Conclusion: Hair-growth Chinese herbal extracts can shorten the hair growth cycle, increase the number of hair follicles, and achieve the effect of treating hair loss.

[0038] Table 1 The time for the back skin of mice to darken after applying the Chinese herbal extracts of Examples 1-5 (days, Mean±SD) As can be seen from Table 1, the time when the back skin of mice after applying the Chinese medicinal extracts of Examples 1-5 turned black was earlier than that of the model group.

Claims

1. A Chinese medicine composition for hair growth, characterized in that: The invention is prepared from the following raw materials in proportion by weight: 15-75 parts of Platycladus orientalis leaves, 10-50 parts of pine needles, 3-15 parts of ginger, 3-15 parts of Angelica dahurica, 3-15 parts of Zedoariae rhizome and 3-15 parts of Tonka cordifolia. The extraction method comprises the following steps: mixing the raw materials, mixing them evenly with a Chinese medicine grinder, and then crushing them, adding anhydrous ethanol, performing ultrasonic treatment for 20 minutes, and filtering to obtain the Chinese medicine extract.

2. The Chinese medicine composition according to claim 1, characterized in that The invention is prepared from the following raw materials in proportion by weight: 60 parts of Platycladus orientalis leaves, 40 parts of pine needles, 12 parts of ginger, 12 parts of Angelica dahurica, 12 parts of Zedoariae rhizome and 12 parts of Tonka osmanthus fragrans.

3. The Chinese medicine composition according to claim 1, characterized in that: The amount of anhydrous ethanol added is 3 times the total weight of the raw materials.

4. A preparation based on the Chinese medicine composition for hair growth according to any one of claims 1 to 3, characterized in that Medically acceptable auxiliary materials are added to the alcohol extract to prepare any one of decoction, granules, pills, tablets, capsules, ointments, syrups and powders.

5. Use of the traditional Chinese medicine composition for hair growth according to any one of claims 1 to 4 in the preparation of a hair growth medicine.

Images