Drug release instrument and endoscope assembly

Abstract

The invention discloses a medicine release instrument and an endoscope assembly, and relates to the technical field of endoscopes. The drug release instrument comprises a first tube body, a balloon and a light-emitting structure. The balloon is arranged to be of a light-transmitting and expandable structure, the inner cavity is defined by the structural layer of the balloon, the inner cavity and the far end of the first tube body are arranged in a sealed mode and communicate with each other, meanwhile, the first tube body extends into the inner cavity, and then the light-emitting structure is arranged in the balloon; light emitted by the light-emitting structure and the photosensitive cross-linked medicine composite layer located outside the structural layer are utilized to induce a cross-linking reaction, after the balloon stretches into the uterus, liquid can be injected into the balloon through the first tube body so that the balloon can be expanded, the balloon can abut against the endometrium after being expanded, and after the light-emitting structure emits the light, the light-emitting structure can emit the light. The photosensitive cross-linked drug composite layer can be adhered to the surface of the endometrium, so that the drug in the photosensitive cross-linked drug composite layer can be fully and tightly adhered to the endometrium, and the endometrium can be continuously treated or repaired.

Description

Technical Field

[0001] The present invention relates to the field of endoscopes, and in particular to a drug releasing device and an endoscope component. Background Art

[0002] The uterine tamponade balloon is a medical device mainly used to treat gynecological diseases such as uterine bleeding. It can be used to place the balloon inside the uterus and expand the balloon to achieve the effect of expansion, compression and hemostasis. It can also be used to deliver drugs to the uterus through the balloon to treat the endometrium or repair the membrane layer.

[0003] However, since the wall thickness of the germinal layer of the endometrium is not sufficient when it is damaged, it is difficult for the uterine tamponade balloon in the prior art to attach drugs to the endometrium to continuously treat the endometrium or repair the membrane layer. Summary of the invention

[0004] The present invention discloses a drug releasing device and an endoscope assembly, so as to at least partially improve the above technical problems.

[0005] In order to solve the above problems, the present invention adopts the following technical solutions: On the one hand, an embodiment of the present application provides a drug release device, comprising: a first tube, a balloon, and a light-emitting structure. The balloon is a light-transmitting structure and can expand. The balloon has a structural layer and a photosensitive cross-linked drug composite layer. The structural layer encloses an inner cavity. The inner cavity is sealed with the distal end of the first tube and is connected to the first tube. The first tube extends into the inner cavity. The light-emitting structure is located in the balloon, and the light emitted by the light-emitting structure can induce a cross-linking reaction with the photosensitive cross-linked drug composite layer.

[0006] In one embodiment, the structural layer includes a first structural portion and a second structural portion stacked along the radial direction of the balloon, the first structural portion is connected to the second structural portion and close to the inner cavity, the photosensitive cross-linked drug composite layer is arranged on the second structural portion, and the first structural portion is configured to expand to the same surface as the second structural portion when the balloon is inflated.

[0007] In one embodiment, the photosensitive cross-linked drug composite layer is disposed in a partial area on the second structural portion, and a first gap exists between adjacent photosensitive cross-linked drug composite layers.

[0008] In one embodiment, the photosensitive cross-linked drug composite layer includes: a photosensitive cross-linking agent, a porous carrier and a drug, the porous carrier is connected to the second structural part, the photosensitive cross-linking agent is arranged on the peripheral side wall of the porous carrier, and the drug is arranged on the porous carrier.

[0009] In one embodiment, there is a second gap between adjacent first structure parts, and the second gap points to the center of the first structure part connecting two adjacent first structure parts.

[0010] In one embodiment, the distal end of the first tube body has a necked area, the radial dimension of the necked area is smaller than the radial dimension of the proximal end of the first tube body, and the structural layer is sealingly connected to the necked area.

[0011] In one embodiment, the area of ​​the first tube extending into the interior of the balloon serves as the light-emitting structure.

[0012] In one embodiment, the drug release device further includes: a second tube body, the second tube body is arranged inside the first tube body, the first tube body is a light-transmitting structure, and the second tube body serves as the light-emitting structure.

[0013] In one embodiment, the drug release device also includes: a second tube body, which is arranged inside the first tube body and connected to the inside of the first tube body, the first tube body and the second tube body are both light-transmitting structures, and the light-emitting structure is detachably arranged inside the second tube body.

[0014] On the other hand, an embodiment of the present application further provides an endoscope assembly, comprising an endoscope and a drug releasing device as described above, wherein the endoscope has an instrument channel, and the drug releasing device is detachably disposed in the instrument channel.

[0015] The technical solution adopted by the present invention can achieve the following beneficial effects: The drug release device provided in the embodiment of the present application is configured to have a light-transmitting and expandable structure in the balloon, and the structural layer of the balloon is formed into an inner cavity, the inner cavity is sealed and connected with the distal end of the first tube body, and the first tube body is extended into the inner cavity, and a light-emitting structure is arranged in the balloon, and the light emitted by the light-emitting structure is used to induce a cross-linking reaction with the photosensitive cross-linked drug composite layer outside the structural layer. When the balloon is extended into the uterus, liquid can be injected into the balloon through the first tube body to expand the balloon, and the balloon can abut against the endometrium after expansion. After the light-emitting structure emits light, the photosensitive cross-linked drug composite layer can adhere to the surface of the endometrium, and the drug in the photosensitive cross-linked drug composite layer can be fully and tightly attached to the endometrium to continuously treat the endometrium or repair the membrane layer. Applying the above-mentioned drug release device to the endoscope assembly can also solve the above-mentioned technical problems. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0017] Figure 1 A schematic diagram showing the structure of a balloon in an endoscope assembly in an embodiment of the present application in a contracted state; Figure 2 A schematic diagram showing the structure of a balloon in an endoscope assembly in an embodiment of the present application in an expanded state; Figure 3 A schematic diagram of the structure of an endoscope assembly in one embodiment of the present application, in which a balloon is in a contracted state after the endoscope assembly is inserted into the uterus; Figure 4 A schematic diagram of the structure of an endoscope assembly in an embodiment of the present application, in which a balloon is in an expanded state after the endoscope assembly is inserted into the uterus; Figure 5 for Figure 1 The enlarged view of point A in the middle; Figure 6 for Figure 2 The enlarged view of point B in the middle; Figure 7 A cross-sectional view showing a partial structure of an endoscope assembly in one embodiment of the present application; Figure 8 A partial structural schematic diagram showing a balloon in a drug release device in an embodiment of the present application in a contracted state; Fig. 9 A schematic diagram showing the structure of a balloon in a drug release device in an embodiment of the present application in an expanded state and in contact with the endometrium.

[0018] In the figure: 1. endoscope assembly; 10. drug release device; 110. first tube body; 111. constriction area; 120. balloon; 121. structural layer; 1211. first structural part; 1212. second structural part; 1213. first gap; 1214. second gap; 122. photosensitive cross-linking drug composite layer; 1221. photosensitive cross-linking agent; 1222. porous carrier; 123. inner cavity; 130. light-emitting structure; 140. second tube body; 20. endoscope; 210. instrument channel; 220. injection channel; 2. uterus. DETAILED DESCRIPTION

[0019] To make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be described in detail below. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other implementation methods obtained by ordinary technicians in this field without creative work belong to the scope of protection of the present invention.

[0020] The terms "first", "second", etc. in the specification and claims of the present application are used to distinguish similar objects, and are not used to describe a specific order or sequence. It should be understood that the data used in this way can be interchangeable under appropriate circumstances, so that the embodiments of the present application can be implemented in an order other than those illustrated or described here, and the objects distinguished by "first", "second", etc. are generally of one type, and the number of objects is not limited. For example, the first object can be one or more. In addition, "and / or" in the specification and claims represents at least one of the connected objects, and the character " / " generally indicates that the objects associated with each other are in an "or" relationship.

[0021] In each embodiment of the present application, "proximal end" and "distal end" refer to the position of each component relative to the user in the use environment, wherein the end closer to the user is designated as the "proximal end" and the end farther from the user is designated as the "distal end".

[0022] The inventive concept of the present application is described here: The uterine tamponade balloon is a medical device mainly used to treat gynecological diseases such as uterine bleeding. It can be used to place the balloon inside the uterus and expand the balloon to achieve the effect of expansion, compression and hemostasis. It can also be used to deliver drugs to the uterus through the balloon to treat the endometrium or repair the membrane layer.

[0023] However, since the wall thickness of the germinal layer of the endometrium is not sufficient when it is damaged, it is difficult for the uterine tamponade balloon in the prior art to attach drugs to the endometrium for continuous treatment of the endometrium or to repair the membrane layer. If a targeted injection of drugs is used, although this can ensure that the drugs can fully contact the endometrium, this method not only has a small range of action, but is also very complicated to operate.

[0024] Based on this, the inventors provide a drug release device and an endoscope assembly. The drug release device can use a photosensitive cross-linking reaction to tightly bond a carrier carrying drugs to the endometrium, thereby achieving drug application over a large area of ​​the endometrium and is easy to operate.

[0025] The following is combined with Figures 1 to 9 , an endoscope assembly 1 and an endoscope 20 provided in the present application are described in detail through specific embodiments and their application scenarios.

[0026] Please also see Figure 1-Figure 4 The embodiment of the present application provides an endoscope assembly 1, which can be used to apply medicine to the endometrium to continuously treat the endometrium or repair the endometrium. The endoscope assembly 1 may include: an endoscope 20 and a drug release device 10, wherein the endoscope 20 can be used as a carrier of the drug release device 10, the drug release device 10 is delivered into the uterus 2 through the endoscope 20, and the drug is attached to the endometrium by the drug release device 10.

[0027] Please also see Figure 5 and Figure 6 The endoscope 20 may have an instrument channel 210 and an injection channel 220. The instrument channel 210 may be used to accommodate the drug release device 10, and the injection channel 220 may be connected to the drug release device 10. In this embodiment, the drug release device 10 is detachably disposed in the instrument channel 210, so that the endoscope 20 can be reused.

[0028] Please also see Figure 5 and Figure 7 The drug release device 10 may include: a first tube body 110, a balloon 120 and a light-emitting structure 130. The balloon 120 may be connected to the first tube body 110. The light-emitting structure 130 may be used to emit light and trigger the photosensitive cross-linking agent 1221 in the balloon 120 to induce a cross-linking reaction, so that the balloon 120 can have adhesion properties, and then when the balloon 120 contacts the endometrium, the drug can be adhered to the endometrium.

[0029] Specifically, the first tube body 110 may be connected to the injection channel 220, and the first tube body 110 may be used to inject liquid into the balloon 120 to expand the balloon 120. The embodiment of the present application does not limit the aforementioned liquid, for example, in some embodiments, it may be physiological saline, etc. The balloon 120 may be connected to the distal end of the first tube body 110 and sealed with the distal end of the first tube body 110. In this embodiment, the balloon 120 may be configured as a light-transmitting and expandable structure.

[0030] In one embodiment, the distal end of the first tube body 110 may have a necked area 111, and the radial dimension of the necked area 111 may be smaller than the radial dimension of the proximal end of the first tube body 110. The balloon 120 may be connected to the necked area 111. This allows the dimensions of the entire drug release device 10 to be consistent, thereby preventing the distal end of the drug release device 10 from becoming larger in size after being connected to the balloon 120, making it difficult to move smoothly in the device channel 210.

[0031] Please also see Figure 8 and Fig. 9The balloon 120 may have a structural layer 121 and a photosensitive cross-linked drug composite layer 122, the structural layer 121 may enclose an inner cavity 123, and the first tube body 110 may extend into the inner cavity 123. It is understandable that, since the balloon 120 has a low structural strength and is prone to collapse when in a contracted state, extending the first tube body 110 into the inner cavity 123 may allow the first tube body 110 to serve as a supporting structure of the balloon 120, thereby facilitating the delivery of the drug release device 10 into the uterus 2. At the same time, during the delivery into the uterus 2, the first tube body 110 may also play a guiding role.

[0032] In a specific embodiment, the photosensitive cross-linked drug composite layer 122 may include: a photosensitive cross-linking agent 1221, a porous carrier 1222, and a drug. The porous carrier 1222 may be used to carry the drug. The embodiment of the present application does not limit the specific form of the porous carrier 1222. For example, in one embodiment, the porous carrier 1222 may be an inorganic carrier, such as silicon dioxide, aluminum hydroxide, etc. For example, in another embodiment, the porous carrier 1222 may also be an organic carrier, such as polyester, polyamide, polyorthoester, polyethylene oxide, polyamide ester, etc., which may be specifically set according to actual conditions. The photosensitive cross-linking agent 1221 may be set on the peripheral side wall of the porous carrier 1222. The photosensitive cross-linking agent 1221 may be used to cooperate with the light emitted by the light-emitting structure 130 and induce a cross-linking reaction, so that the porous carrier 1222 can be bonded to the endometrium, so that the drug can fully contact the endometrium. The embodiments of the present application also do not limit the specific form of the drug, for example, it can be platelet-rich plasma (PRP).

[0033] Please refer to Figure 8 , the structural layer 121 may include a first structural portion 1211 and a second structural portion 1212 stacked along the radial direction of the balloon 120, the first structural portion 1211 may be connected to the second structural portion 1212, and the first structural portion 1211 is closer to the inner cavity 123 than the second structural portion 1212. The photosensitive cross-linked drug composite layer 122 may be disposed on the second structural portion 1212, that is, in this embodiment, the photosensitive cross-linked drug composite layer 122 may be located on the outer surface of the balloon 120, and the structural layer 121 may be located on the inner surface of the balloon 120. Among them, the first structural portion 1211 may be configured to expand to the same surface as the second structural portion 1212 after expansion.

[0034] Further, in one embodiment, the photosensitive cross-linked drug composite layer 122 is disposed in a partial area on the second structural portion 1212, specifically, the porous carrier 1222 can be disposed in a partial area on the second structural portion 1212, and a first gap 1213 is provided between adjacent photosensitive cross-linked drug composite layers 122. It can be understood that, since the photosensitive cross-linked drug composite layer 122 is generally opaque, providing the first gap 1213 between adjacent photosensitive cross-linked drug composite layers 122 can facilitate the light emitted by the light emitting structure 130 to induce a cross-linking reaction with the photosensitive cross-linking agent 1221 in the photosensitive cross-linked drug composite layer 122.

[0035] In one embodiment, there may be a second gap 1214 between adjacent first structural parts 1211, and the second gap 1214 points to the center of the first structural part 1211 connected to the two adjacent first structural parts 1211. That is, in this embodiment, when the first structural part 1211 is unfolded, the force on the second structural part 1212 can be made more uniform, so as to avoid the first structural part 1211 causing a partial area of ​​the second structural part 1212 to collapse during the unfolding process, thereby causing the porous carrier 1222 located on the second structural part 1212 to loosen and fall off.

[0036] The embodiment of the present application does not limit the specific position and form of the light emitting structure 130. For example, in one embodiment, the area where the first tube 110 extends into the interior of the balloon 120 can serve as the light emitting structure 130. In a preferred embodiment, the first tube 110 can also be configured as a light-transmitting structure, which can further facilitate the cross-linking reaction of the photosensitive cross-linking agent 1221.

[0037] In addition, in another embodiment, the drug release device 10 may further include a second tube body 140, and the second tube body 140 may be arranged inside the first tube body 110. The second tube body 140 may serve as a light-emitting structure 130, and in this embodiment, the first tube body 110 is also a light-transmitting structure. It can be understood that the embodiment of the present application does not limit the connection method between the second tube body 140 and the first tube body 110. For example, it can be an integrally molded setting, or it can be a sliding setting and a detachable connection, etc., and can be specifically set according to actual conditions.

[0038] For another example, in yet another embodiment, the drug release device 10 may also include a second tube 140, which may also be disposed inside the first tube 110. However, in this embodiment, the second tube 140 is only used as a pipeline, and the light-emitting structure 130 is detachably disposed inside the second tube 140. It is understandable that, since the first tube 110 needs to be used to inject liquid into the inner cavity 123 of the balloon 120, the light-emitting structure 130 is disposed separately inside the second tube 140 to avoid the liquid from affecting the light-emitting structure 130.

[0039] In some other embodiments, the light emitting structure 130 may also be disposed between the structural layer 121 and the photosensitive cross-linking drug composite layer 122, so that the distance between the light emitting structure 130 and the photosensitive cross-linking agent 1221 is closer, thereby improving the efficiency of the cross-linking reaction of the photosensitive cross-linking agent 1221. Where the light emitting structure 130 is disposed may be determined according to actual conditions.

[0040] The drug release device 10 provided in the embodiment of the present application is configured such that the balloon 120 is a light-transmitting and expandable structure, and the structural layer 121 of the balloon 120 is surrounded by an inner cavity 123, the inner cavity 123 is sealed and connected with the distal end of the first tube 110, and the first tube 110 is inserted into the inner cavity 123, and a light-emitting structure 130 is arranged in the balloon 120, and the light emitted by the light-emitting structure 130 is used to induce a cross-linking reaction with the photosensitive cross-linked drug composite layer 122 located outside the structural layer 121. When the balloon 120 is inserted into the uterus 2, liquid can be injected into the balloon 120 through the first tube 110 to expand the balloon 120. After the balloon 120 is expanded, it can abut against the endometrium. After the light-emitting structure 130 emits light, the photosensitive cross-linked drug composite layer 122 can adhere to the surface of the endometrium, and then the drug located in the photosensitive cross-linked drug composite layer 122 can be fully and tightly attached to the endometrium, so as to continuously treat the endometrium or repair the membrane layer. Applying the above-mentioned drug release device 10 to the endoscope assembly 1 can also solve the above-mentioned technical problems.

[0041] It should be noted that, in this article, the terms "include", "comprises" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, an element defined by the sentence "comprises a ..." does not exclude the existence of other identical elements in the process, method, article or device including the element.

[0042] In addition, it should be noted that the scope of the methods and devices in the embodiments of the present application is not limited to performing functions in the order shown or discussed, and may also include performing functions in a substantially simultaneous manner or in a reverse order according to the functions involved. For example, the described methods may be performed in an order different from that described, and various steps may be added, omitted, or combined. In addition, features described with reference to certain examples may be combined in other examples.

[0043] The above description is only a specific implementation mode of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can easily think of changes or substitutions within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A drug release device, characterized in that: include: first tube body; A balloon, wherein the balloon is a light-transmitting structure and is expandable, and comprises a structural layer and a photosensitive cross-linked drug composite layer, wherein the structural layer encloses an inner cavity, wherein the inner cavity is sealed with the distal end of the first tube body and is in communication with the first tube body, and wherein the first tube body extends into the inner cavity; as well as, A light-emitting structure is located in the balloon, and the light emitted by the light-emitting structure can induce a cross-linking reaction with the photosensitive cross-linking drug composite layer.

2. The drug release device according to claim 1, characterized in that: The structural layer includes a first structural part and a second structural part stacked along the radial direction of the balloon, the first structural part is connected to the second structural part and close to the inner cavity, the photosensitive cross-linked drug composite layer is arranged on the second structural part, and the first structural part is configured to expand to the same surface as the second structural part when the balloon is inflated.

3. The drug release device according to claim 2, characterized in that: The photosensitive cross-linked drug composite layer is disposed in a partial area on the second structural portion, and a first gap is provided between adjacent photosensitive cross-linked drug composite layers.

4. The drug release device according to claim 3, characterized in that: The photosensitive cross-linking drug composite layer includes: a photosensitive cross-linking agent, a porous carrier and a drug, the porous carrier is connected to the second structural part, the photosensitive cross-linking agent is arranged on the peripheral side wall of the porous carrier, and the drug is arranged on the porous carrier.

5. The drug release device according to claim 2, characterized in that: There is a second gap between adjacent first structure parts, and the second gap points to the center of the first structure part connecting two adjacent first structure parts.

6. The drug release device according to claim 1, characterized in that: The distal end of the first tube body has a necked area, the radial dimension of the necked area is smaller than the radial dimension of the proximal end of the first tube body, and the structural layer is sealingly connected to the necked area.

7. The drug release device according to any one of claims 1 to 5, characterized in that: The area of ​​the first tube extending into the interior of the balloon serves as the light-emitting structure.

8. The drug release device according to any one of claims 1 to 5, characterized in that: The drug release device further includes: a second tube body, which is arranged inside the first tube body, the first tube body is a light-transmitting structure, and the second tube body serves as the light-emitting structure.

9. The drug release device according to any one of claims 1 to 5, characterized in that: The drug release device also includes: a second tube body, which is arranged inside the first tube body and communicated with the inside of the first tube body. The first tube body and the second tube body are both light-transmitting structures, and the light-emitting structure is detachably arranged inside the second tube body.

10. An endoscope assembly, characterized in that: It comprises an endoscope and a drug releasing device as claimed in any one of claims 1 to 9, wherein the endoscope has an instrument channel, and the drug releasing device is detachably disposed in the instrument channel.

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