Composition for improving female reproductive health, application of composition, solid beverage and preparation method of solid beverage

Abstract

The invention relates to the field of solid drinks, in particular to a composition for improving female reproductive health, application of the composition, a solid drink and a preparation method of the solid drink. The composition is prepared from the following components in parts by mass: 1.0 to 2.1 parts of haematococcus pluvialis powder; 1.4 to 2.8 parts of a dandelion extract; 1.6 to 3.0 parts of an emblic leafflower fruit extract; 0.8 to 1.6 parts of schizophyllum commune polysaccharide; and 2.5 to 3.5 parts of collagen peptide. The dandelion extract in the composition has a relatively strong antibacterial effect, and the schizophyllum commune polysaccharide can promote the growth of beneficial bacteria (lactic acid bacteria) in vagina, maintain flora balance, improve the immunity of the organism and reduce the probability of bacterial invasion. The collagen peptide can promote wound healing and mucous membrane repair. The schizophyllum commune polysaccharide in the composition wraps the small-molecule collagen peptide, so that the targeted positioning effect of the schizophyllum commune polysaccharide is promoted. The components are matched to achieve a synergistic effect, inflammation can be reduced, and post-inflammation repair is promoted.

Description

Technical Field

[0001] The present application relates to the field of solid beverages, and in particular, to a composition for improving female reproductive health and its application, a solid beverage and its preparation method. Background Art

[0002] The 2022 China Reproductive Health Research Report on Women of Childbearing Age shows that 70.6% of women of childbearing age have experienced gynecological symptoms in the past year, and the top confirmed gynecological diseases are candidal vaginitis (23.8%), breast hyperplasia (18.6%), pelvic inflammatory disease (14.2%), and cervicitis (13.9%). This is due to the physiological structure of women, which can easily cause various gynecological problems.

[0003] The traditional treatment for female reproductive health problems is the use of antibiotics and various washes, but the recurrence rate is high after discontinuation of the medication, and it also aggravates the imbalance of the female reproductive tract microecological balance. Summary of the invention

[0004] The purpose of the embodiments of the present application is to provide a composition for improving female reproductive health and its application, a solid beverage and its preparation method.

[0005] After research, it is believed that the pathogens of urinary tract infection mainly include Gram-negative bacteria, Gram-positive bacteria, and some fungi. The most common pathogen is Escherichia coli, which belongs to Gram-negative bacteria, followed by Escherichia coli, Proteus, etc.

[0006] The symptoms of post-inflammatory infection in women will vary depending on the type of inflammation. The basic symptoms of inflammation clinically include vulvar itching, frequent urination, urgent and painful urination, abnormal leucorrhea, painful sexual intercourse, lower abdominal distension, irregular menstruation and pain during menstruation.

[0007] In view of this, the first aspect of the present application provides a composition for improving female reproductive health, which is composed of the following components by weight:

[0008] 1.0-2.1 parts of Haematococcus pluvialis powder;

[0009] 1.4-2.8 parts of dandelion extract;

[0010] 1.6-3.0 parts of emblica extract;

[0011] 0.8-1.6 parts of Schizophyllan; and

[0012] Collagen peptide 2.5-3.5 parts.

[0013] The composition provided above in the present application can prevent or alleviate female reproductive health problems. The combination of the various components of the composition can cooperate with each other to play a synergistic effect, quickly and effectively improve female reproductive health problems, and at the same time can improve the antioxidant capacity in women and delay female aging. In the above technical scheme, the dandelion extract in the composition has a strong antibacterial effect, and the schizophyllum polysaccharide can promote the growth of beneficial vaginal bacteria (lactic acid bacteria), maintain the balance of the flora, and improve the body's immunity and reduce the probability of bacterial invasion. Collagen peptides can promote wound healing and promote mucosal repair. The schizophyllum polysaccharide in the composition encapsulates small molecule collagen peptides to promote its targeting and positioning effect. The combination between the compositions has a synergistic effect, can reduce inflammation, and promote post-inflammatory repair.

[0014] In other embodiments of the present application, the above-mentioned composition for improving women's health is composed of the following components in parts by mass:

[0015] 1.1-2.1 parts of Haematococcus pluvialis powder;

[0016] 1.7-2.5 parts of dandelion extract;

[0017] 1.6-2.8 parts of emblica extract;

[0018] 0.5-1.6 parts of Schizophyllan; and

[0019] Collagen peptide 1.5-3.5 parts.

[0020] In other embodiments of the present application, the composition does not contain an acid-rich component.

[0021] In other embodiments of the present application, the acid-rich component includes at least one of citrus fruit powder, lemon fruit powder, grapefruit fruit powder, kiwi fruit powder, hawthorn fruit powder and extracts thereof.

[0022] In other embodiments of the present application, the composition can inhibit Staphylococcus aureus, Escherichia coli and Candida albicans.

[0023] In a second aspect, the present application provides an application of a composition for improving female reproductive health in the preparation of a solid beverage for promoting the repair of the female reproductive system.

[0024] In a third aspect, the present application provides a solid beverage, which comprises, by mass percentage: 30%-50% of the composition for improving female reproductive health according to any one of claims 1-6; and 50%-70% of maltodextrin.

[0025] In other embodiments of the present application, the solid beverage comprises, by mass percentage:

[0026] 30%-50% composition for improving female reproductive health;

[0027] 45%-60% maltodextrin;

[0028] 1% to 5% edible flavoring; and

[0029] 1%~5% sweetener.

[0030] In a fourth aspect, the present application provides a method for preparing a solid beverage, the preparation method comprising:

[0031] Using water as a binder, dandelion extract, emblica extract, schizophyllan and maltodextrin are granulated to obtain mixed granules;

[0032] Dispersing and mixing a portion of collagen peptide powder, sweetener, and edible flavor evenly to obtain a dispersion;

[0033] Mix the mixed granules, dispersion, Haematococcus pluvialis powder and the remaining collagen peptide powder.

[0034] In other embodiments of the present application, water is used as a binder to granulate dandelion extract, emblica extract, schizophyllan polysaccharide and maltodextrin to obtain mixed granules; comprising:

[0035] The inlet air temperature is controlled at 75℃-80℃ and the outlet air temperature is controlled at 55℃-60℃ for granulation.

[0036] In other embodiments of the present application, the moisture content of the material is controlled to be less than 5% at the end of granulation.

[0037] In other embodiments of the present application, after granulation, the material is passed through a 10-30 mesh sieve, and the material under the sieve is taken. DETAILED DESCRIPTION

[0038] In order to make the purpose, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments.

[0039] Therefore, the following detailed description of the embodiments of the present application is not intended to limit the scope of the present application for protection, but merely represents selected embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present application.

[0040] The present application provides a composition for improving female reproductive health, which is composed of the following components by weight:

[0041] 1.0-2.1 parts of Haematococcus pluvialis powder;

[0042] 1.4-2.8 parts of dandelion extract;

[0043] 1.6-3.0 parts of emblica extract;

[0044] 0.8-1.6 parts of Schizophyllan; and

[0045] Collagen peptide 2.5-3.5 parts.

[0046] In the above technical solution, the various components in the composition are compounded with each other to achieve a synergistic effect, have antibacterial and anti-inflammatory effects, can reduce the recurrence of inflammation, thereby helping to promote the repair of the female reproductive system and improve women's health.

[0047] Further optionally, illustratively, in some embodiments of the present application, the composition for improving women's health is composed of the following components in parts by mass:

[0048] 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0 or 2.1 parts of Haematococcus pluvialis powder;

[0049] 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7 or 2.8 parts of dandelion extract;

[0050] 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9 or 3.0 parts of emblica extract;

[0051] 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5 or 1.6 parts of Schizophyllan; and

[0052] 2.5 parts, 2.6 parts, 2.7 parts, 2.8 parts, 2.9 parts, 3.0 parts, 3.1 parts, 3.1 parts, 3.1 parts, 3.1 parts or 3.5 parts of collagen peptide.

[0053] The dandelion extract is an extract of the dried whole grass of Taraxacum mongolicum Hand.-Mazz., Taraxacum borealisinense Kitam. or several plants of the same genus in the Asteraceae family. The dandelion extract has different degrees of inhibitory effects on Staphylococcus aureus, Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, etc. In the above technical scheme, the dandelion extract is compounded with other ingredients to achieve a synergistic effect, which can improve the antibacterial and anti-inflammatory effects of the entire composition, reduce the recurrence of inflammation, promote the repair of the female reproductive system, and improve women's health.

[0054] Further optionally, in some embodiments of the present application, the preparation process of the dandelion extract comprises: extracting the whole dandelion herb with 20 times water twice, each time for 60 min to 90 min, and then filtering, centrifuging, concentrating and spray-drying to obtain the dandelion extract.

[0055] The emblica extract is an extract of the dried mature fruit of the Euphorbiaceae plant Phyllanthus emblica L. The extract has anti-inflammatory and anti-aging effects. In the above technical scheme, the emblica extract is compounded with other ingredients to achieve a synergistic effect, which can improve the anti-inflammatory and anti-aging effects of the entire composition, reduce the recurrence of inflammation, promote the repair of the female reproductive system, and improve the health of women.

[0056] Further optionally, in some embodiments of the present application, the preparation process of the above-mentioned emblica extract includes: using the dried mature fruit emblica of the Euphorbiaceae plant emblica Phyllanthus emblica L. as a raw material, extracting, filtering, and freeze-drying. After the emblica is crushed, 10-15 times the volume of water is added for extraction, and the extraction is performed at room temperature for 3 times, each time for 1-1.5 hours. The extracts are combined, filtered, centrifuged, concentrated, and freeze-dried, and the polyphenol content of the prepared emblica extract is ≥15%.

[0057] Schizophyllum polysaccharide is obtained by extracting, filtering, purifying and drying the fruiting bodies of Schizophyllum in solid culture. Or it is obtained by liquid fermentation culture, filtering, purifying and drying of Schizophyllum strains. Schizophyllum polysaccharide has anti-inflammatory, anti-aging and immunity-enhancing effects. In the above technical scheme, Schizophyllum polysaccharide is compounded with other ingredients to achieve a synergistic effect, which can improve the anti-inflammatory and anti-aging effects of the entire composition, reduce the recurrence of inflammation, help improve immunity, promote the repair of the female reproductive system, and improve the health of women.

[0058] Haematococcus pluvialis is a microscopic single-cell green algae. Under certain culture conditions (suitable light, temperature, pH, etc.), the algae synthesizes rich astaxanthin, which is a non-vitamin A source fat-soluble carotenoid with super antioxidant activity. Studies have shown that it has the effects of enhancing the body's immunity and anti-aging. In the above technical scheme, the compounding of Haematococcus pluvialis with other ingredients can achieve a synergistic effect, which can improve the anti-inflammatory and anti-aging effects of the entire composition, can reduce the recurrence of inflammation, is beneficial to improve immunity, promote the repair of the female reproductive system, and improve the health of women.

[0059] Further, in some embodiments of the present application, the composition is composed of the following components in parts by mass:

[0060] 1.1-2.1 parts of Haematococcus pluvialis powder;

[0061] 1.7-2.5 parts of dandelion extract;

[0062] 1.6-2.8 parts of emblica extract;

[0063] 0.5-1.6 parts of Schizophyllan; and

[0064] Collagen peptide 1.5-3.5 parts.

[0065] Furthermore, in some embodiments of the present application, the composition does not contain acid-rich ingredients.

[0066] After research, the inventor unexpectedly found that the composition of the present application needs to be compounded with the above-mentioned components. When compounded, a synergistic effect can be achieved; however, when other components such as raw materials rich in acid components are added, some inhibitory effects will be produced, reducing the antibacterial and anti-inflammatory effects of the composition. Therefore, the composition of the present application does not contain raw materials rich in acid components.

[0067] Illustratively, in some embodiments of the present application, the above-mentioned composition does not contain at least one or a combination of multiple of citrus fruit powder, lemon fruit powder, grapefruit fruit powder, kiwi fruit powder, hawthorn fruit powder and extracts thereof.

[0068] Furthermore, in some embodiments of the present application, the composition does not contain citrus fruit powder and extracts thereof.

[0069] Furthermore, in some embodiments of the present application, the composition can inhibit Staphylococcus aureus, Escherichia coli and Candida albicans.

[0070] Illustratively, in some embodiments of the present application, the composition can inhibit three bacteria: Staphylococcus aureus, Escherichia coli, and Candida albicans.

[0071] Some embodiments of the present application provide a solid beverage, which comprises, by mass percentage: 30%-50% of the composition for improving female reproductive health provided in any of the aforementioned embodiments; and 50%-70% of maltodextrin.

[0072] In the above technical scheme, the solid beverage is beneficial to improve women's reproductive health by including the aforementioned composition. In the aforementioned composition, the combination of each component can cooperate with each other to play a synergistic role, quickly and effectively improve women's reproductive health problems, and at the same time can improve the antioxidant capacity of women and delay women's aging. In the above technical scheme, the dandelion extract in the composition has a strong antibacterial effect, and the schizophyllum polysaccharide can promote the growth of beneficial vaginal bacteria (lactic acid bacteria), maintain the balance of the flora, and improve the body's immunity and reduce the probability of bacterial invasion. Collagen peptides can promote wound healing and promote mucosal repair. The schizophyllum polysaccharide in the composition encapsulates small molecule collagen peptides to promote its targeting and positioning effect. The combination of the compositions has a synergistic effect, which can reduce inflammation and promote post-inflammatory repair.

[0073] Further optionally, exemplarily, in some embodiments of the present application, a solid beverage comprises, by mass percentage: 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, 50% or a content within the range between any two of the aforementioned values ​​of the composition for improving women's health provided by any of the aforementioned embodiments; and 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, 70% or a content within the range between any two of the aforementioned values ​​of maltodextrin.

[0074] Further, in some embodiments of the present application, the solid beverage comprises, by mass percentage:

[0075] 30%-50% composition for improving female reproductive health;

[0076] 45%-60% maltodextrin;

[0077] 1% to 5% edible flavoring; and

[0078] 1%~5% sweetener.

[0079] For example, in some embodiments of the present application, the solid beverage includes, by mass percentage:

[0080] 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49% or 50% of a composition that improves female reproductive health;

[0081] 45%, 46%, 47%, 48%, 49%, 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59% or 60% maltodextrin;

[0082] 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5% or 5% flavoring; and

[0083] 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5% or 5% sweetener.

[0084] The present application provides a method for preparing a solid beverage, the preparation method comprising:

[0085] Using water as a binder, dandelion extract, emblica extract, schizophyllan and maltodextrin are granulated to obtain mixed granules;

[0086] Dispersing and mixing a portion of collagen peptide powder, sweetener, and edible flavor evenly to obtain a dispersion;

[0087] Mix the mixed granules, dispersion, Haematococcus pluvialis powder and the remaining collagen peptide powder.

[0088] The above preparation method can effectively prepare the solid beverage provided by any of the above embodiments; the prepared solid beverage has good stability and is conducive to maintaining activity.

[0089] Further, in some embodiments of the present application, water is used as a binder to granulate dandelion extract, emblica extract, schizophyllan and maltodextrin to obtain mixed granules; comprising:

[0090] The inlet air temperature is controlled at 75℃-80℃ and the outlet air temperature is controlled at 55℃-60℃ for granulation.

[0091] In the above technical solution, the granulation is carried out by controlling the air inlet temperature to 75°C-80°C and the air outlet temperature to 55°C-60°C; a solid beverage with stable appearance and performance can be produced.

[0092] For example, in some embodiments of the present application, water is used as a binder to granulate dandelion extract, emblica extract, schizophyllan and maltodextrin to obtain mixed granules; comprising:

[0093] The inlet air temperature is controlled to be 75°C, 76°C, 77°C, 78°C, 79°C, 80°C or a temperature range between any two of the aforementioned values; the outlet air temperature is controlled to be 55°C, 56°C, 57°C, 58°C, 59°C, 60°C or a temperature range between any two of the aforementioned values ​​for granulation.

[0094] Further optionally, in some embodiments of the present application, the moisture content of the material is controlled to be less than 5% at the end of granulation.

[0095] Optionally, in some embodiments of the present application, the moisture content of the material is controlled to be 4.9%, 4.8%, 4.5%, 4.0%, 3.5%, 3%, 2%, 1% or a moisture content in a range between any two of the foregoing values ​​at the end of granulation.

[0096] Further optionally, in some embodiments of the present application, after granulation, the material is passed through a 10-30 mesh sieve, and the material under the sieve is taken.

[0097] In the above technical solution, after the granulation is completed, the material is passed through a 10-30 mesh sieve, and the particle size of the obtained solid beverage is moderate, which is more conducive to preparing a solid beverage with stable performance with a dispersion of other raw materials.

[0098] Illustratively, in some embodiments of the present application, after granulation, the material is passed through a sieve of 10 mesh, 12 mesh, 15 mesh, 18 mesh, 20 mesh, 22 mesh, 25 mesh, 28 mesh, 30 mesh or a range between any two of the foregoing values, and the material under the sieve is taken.

[0099] Exemplarily, in some embodiments of the present application, the preparation method of the solid beverage is as follows:

[0100] (1) Weighing: Weigh the materials according to the formula and set aside;

[0101] (2) Granulation: The dandelion extract, emblica extract, schizophyllan and maltodextrin weighed in step (1) are put into a fluidized bed granulator for one-step granulation, using water as a binder, controlling the air inlet temperature to 75-80° C. and the air outlet temperature to 55-60° C. At the end of granulation, the moisture content of the material is controlled to be less than 5%, and the material is sieved through a 20-mesh sieve;

[0102] (3) Premixing: Take an appropriate amount of collagen peptide powder, add the formulated amount of sweetener and edible flavor, and disperse and mix multiple times;

[0103] (4) Total mixing: the granular mixture obtained in step (2), the premix in step (3), the material Haematococcus pluvialis powder and the remaining collagen peptide powder are respectively put into a three-dimensional mixer. After mixing for 20 minutes, the material is discharged for use;

[0104] (5) Packaging: The total mixed powder in step (4) is packaged using a multi-row packaging machine to control the net content of the product.

[0105] The features and performance of the present application are further described in detail below in conjunction with the embodiments:

[0106] Examples and Comparative Examples

[0107] A composition for improving female reproductive health is provided. The formulation compositions of various embodiments or comparative examples are shown in Table 1.

[0108] Table 1

[0109]

[0110]

[0111] Process for preparing the composition:

[0112] In each of the above embodiments or comparative examples, the raw materials were mixed uniformly according to the respective formulas in Table 1.

[0113] Performance Testing

[0114] The various properties of the compositions prepared in various embodiments or comparative examples were tested:

[0115] 1. Antibacterial effect experiment

[0116] The test bacteria (Escherichia coli, Staphylococcus aureus, Candida albicans) are prepared into a bacterial suspension, and 0.1 ml of the test bacterial suspension is evenly coated on the corresponding solid culture medium to make a bacterial plate, and then a filter paper with a diameter of 6 mm is placed in the middle of the solid culture medium, and 10 μL of the sample solution or blank solution of each embodiment or comparative example (the mixed sample is dissolved in water to prepare a concentration of 20 mg / ml) is dripped on the sterile filter paper, and 10 μL of the filter paper with sterile water is dripped as a blank. Incubate inverted in a 37°C incubator for 24 hours, measure the diameter of the inhibition zone with a vernier caliper, measure each inhibition zone 3 times in different directions, and record the average value. The larger the diameter of the inhibition zone, the better the antibacterial effect.

[0117] The experimental results are shown in Table 2.

[0118] Table 2

[0119]

[0120] From the test results in Table 2 above, it can be seen that the diameter of the Staphylococcus aureus inhibition zone, the diameter of the Escherichia coli inhibition zone, and the diameter of the Candida albicans inhibition zone of each embodiment sample are greater than the diameter of the Staphylococcus aureus inhibition zone, the diameter of the Escherichia coli inhibition zone, and the diameter of the Candida albicans inhibition zone of each comparative example sample; thus, it is shown that the inhibitory effects of each embodiment sample of the present application on Staphylococcus aureus, Escherichia coli, and Candida albicans are higher than the inhibitory effects of each comparative example sample on Staphylococcus aureus, Escherichia coli, and Candida albicans. It can be said that the composition of the present application has excellent antibacterial effects on Staphylococcus aureus, Escherichia coli, and Candida albicans.

[0121] Furthermore, by comparing Comparative Example 5 with Example 3, the inventor unexpectedly found that when other ingredients such as raw materials rich in acid components (citrus fruit powder) are arbitrarily added to the composition of the present application, the active effect of the polyphenol components will be affected, and the antibacterial effect of the composition will be reduced. Therefore, it can be inferred that the composition of the present application cannot contain raw materials rich in acid components.

[0122] 2. Anti-inflammatory effect experiment

[0123] In a 96-well plate, RAW264.7 cell suspension (5.0×10 4 / mL) 200μL, placed in a 37℃, 5% CO2 incubator for incubation for 4h, discard the culture medium, add 100μL of complete culture medium with a final concentration of 1μg / mL LPS (complete culture medium was added to the blank control group). 37℃, 5% CO2 incubator for 24h, discard the supernatant and wash three times with PBS, add 200μL of fresh complete culture medium containing each embodiment or comparative example sample, keep the final concentration of DMSO at 0.2%; complete culture medium was added to the model group, and 100μg / mL dexamethasone was added to the positive control group). After culturing in a 37℃, 5% CO2 incubator for 24h, the cell supernatant was transferred to another 96-well cell culture plate, and 100μL of Griess A and Griess B mixed reagent (1:1) was added to each well, and the reaction was carried out in the dark and away from light for 10min, and the OD value was measured at 550nm. The levels of cytokines (TNF-α, IL-6) in the culture supernatant of RAW264.7 cells were detected by ELISA. The inhibition rate of pro-inflammatory cytokine production of each embodiment or comparative example sample was calculated according to the following formula:

[0124] Inhibition rate of pro-inflammatory cytokine production (%) = [1-C1 / C0] × 100%;

[0125] Among them, C0 represents the concentration of pro-inflammatory cytokines produced when only the inducer LPS is added, and C1 represents the concentration of pro-inflammatory cytokines produced when the inducer LPS and the sample are added simultaneously.

[0126] The experimental results are shown in Table 3.

[0127] Table 3

[0128]

[0129]

[0130] From the data in the above table, it can be seen that the TNF-α inhibition rate and IL-6 inhibition rate of each embodiment are higher than the TNF-α inhibition rate and IL-6 inhibition rate of each comparative example; thus, it is shown that the inhibition rate of pro-inflammatory cytokine production of each embodiment is higher than that of each comparative example. That is, the composition provided in the embodiments of the present application can effectively enhance the anti-inflammatory effect.

[0131] Furthermore, by comparing Comparative Example 5 with Example 3, the inventor unexpectedly found that when other ingredients such as raw materials rich in acid components (citrus fruit powder) are arbitrarily added to the composition of the present application, the active effects of the polyphenol components will be affected, and the anti-inflammatory effect of the composition will be reduced. Therefore, it can be inferred that the composition of the present application cannot contain raw materials rich in acid components.

[0132] 3. Population test:

[0133] The solid beverage was prepared using the formula of Example 3, and the preparation process was as follows:

[0134] (1) Weighing: Weigh the materials according to the formula and set aside;

[0135] (2) Granulation: The dandelion extract, emblica extract, schizophyllan and maltodextrin weighed in step (1) are put into a fluidized bed granulator for one-step granulation, using water as a binder, and controlling the inlet air temperature to 80° C. and the outlet air temperature to 60° C. At the end of granulation, the moisture content of the material is controlled to be less than 5%, and the material is sieved through a 20-mesh sieve;

[0136] (3) Premixing: Take an appropriate amount of collagen peptide powder, add the formulated amount of sweetener and edible flavor, and disperse and mix multiple times;

[0137] (4) Total mixing: the granular mixture obtained in step (2), the premix in step (3), the material Haematococcus pluvialis powder and the remaining collagen peptide powder are respectively put into a three-dimensional mixer. After mixing for 20 minutes, the material is discharged for use;

[0138] (5) Packaging: The total mixed powder in step (4) is packaged using a multi-row packaging machine to control the net content of the product to 5 g / bag.

[0139] The solid beverage prepared as above was used to conduct a population test:

[0140] Women aged 30 and above were selected to consume the product once a day, 1 bag each time, with warm water for drinking, for 56 consecutive days. A questionnaire survey was conducted on the test subjects' feelings about the product, including changes in vaginal discharge, bad odor in the private parts, color of private discharge, difficulty urinating, and changes in burning and itching.

[0141] The questionnaire results showed that 80% of the users had some improvement in their symptoms. After 56 days of stopping the product and continuing to observe for 28 days, almost no users experienced the previous vaginal discomfort.

[0142] The above description is only the preferred embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A composition for improving female reproductive health, characterized in that: In parts by mass, it is composed of the following ingredients: 1.0-2.1 parts of Haematococcus pluvialis powder; 1.4-2.8 parts of dandelion extract; 1.6-3.0 parts of emblica extract; 0.8-1.6 parts of Schizophyllan; and Collagen peptide 2.5-3.5 parts.

2. The composition for improving female reproductive health according to claim 1, characterized in that: In parts by mass, it is composed of the following ingredients: 1.1-2.1 parts of Haematococcus pluvialis powder; 1.7-2.5 parts of dandelion extract; 1.6-2.8 parts of emblica extract; 0.5-1.6 parts of Schizophyllan; and Collagen peptide 1.5-3.5 parts.

3. The composition for improving female reproductive health according to claim 1, characterized in that: The composition does not contain acid-rich ingredients.

4. The composition for improving female reproductive health according to claim 3, characterized in that: The acid-rich component includes at least one of citrus fruit powder, lemon fruit powder, grapefruit fruit powder, kiwi fruit powder, hawthorn fruit powder and extracts thereof.

5. The composition for improving female reproductive health according to any one of claims 1 to 4, characterized in that: The composition can inhibit Staphylococcus aureus, Escherichia coli and Candida albicans.

6. Use of the composition for improving female reproductive health according to any one of claims 1 to 5 in the preparation of a solid beverage for promoting the repair of female reproductive system.

7. A solid beverage, characterized in that: In terms of mass percentage, the solid beverage comprises: 30%-50% of the composition for improving female reproductive health according to any one of claims 1 to 6; and 50%-70% maltodextrin.

8. The solid beverage according to claim 7, characterized in that: In terms of mass percentage, the solid beverage comprises: 30%-50% of the composition for improving female reproductive health; 45%-60% of the maltodextrin; 1% to 5% edible flavoring; and 1%~5% sweetener.

9. The method for preparing a solid beverage according to any one of claims 7 to 8, characterized in that: The preparation method comprises: Using water as a binder, dandelion extract, emblica extract, schizophyllan and maltodextrin are granulated to obtain mixed granules; Dispersing and mixing a portion of collagen peptide powder, sweetener, and edible flavor evenly to obtain a dispersion; The mixed particles, the dispersion, Haematococcus pluvialis powder and the remaining collagen peptide powder are mixed.

10. The method for preparing a solid beverage according to claim 9, characterized in that: The method uses water as a binder to granulate dandelion extract, emblica extract, schizophyllan and maltodextrin to obtain mixed granules; comprising: Control the inlet air temperature to 75℃-80℃ and the outlet air temperature to 55℃-60℃ for granulation; Optionally, the moisture content of the material is controlled to be less than 5% at the end of granulation; Optionally, after granulation, the material is passed through a 10-30 mesh sieve, and the material under the sieve is taken.

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