Novel derivatives for treatment of TRPM3-mediated disorders

Abstract

The present invention relates to compounds useful in the prevention or treatment of TRPM3-mediated disorders, more particularly disorders selected from the group consisting of pain, epilepsy and inflammatory hypersensitivity. The invention also relates to a method for preventing or treating the TRPM3-mediated condition.

Description

Technical Field

[0001] The present invention relates to compounds that can be used to prevent or treat TRPM3-mediated disorders, more particularly disorders selected from pain, epilepsy and inflammatory hypersensitivity reactions. The present invention also relates to a method for preventing or treating said TRPM3-mediated disorders. Background Art

[0002] The TRP superfamily consists of proteins with six transmembrane domains (6TM) that assemble as homo- or heterotetramers to form cation-permeable ion channels. The name TRP is derived from the Drosophila trp (transient receptor potential) mutant, which characterizes Drosophila photoreceptors as having a transient receptor potential in response to sustained light. Over the past 15 years, trp-related channels have been identified in yeast, worms, insects, fish, and mammals, including 27 TRPs in humans. Based on sequence homology, TRP channels can be divided into seven subfamilies: TRPC, TRPV, TRPM, TRPA, TRPP, TRPML, and TRPN.

[0003] Members of the TRP superfamily are likely expressed in all mammalian organs and cell types, and great progress has been made in recent years in understanding their physiological roles. The tailored selectivity of certain TRP channels enables them to be expressed in the presence of Ca 2+ Mg 2+ The TRPs play a key role in the cellular uptake and / or transepithelial transport of trace metal ions. In addition, the sensitivity of TRP channels to a wide range of chemical and physical stimuli allows them to act as specialized biosensors, participating in processes from vision to taste and touch. Specifically, several members of the TRP superfamily show very high sensitivity to temperature. These so-called thermal TRPs are highly expressed in sensory neurons and / or skin keratinocytes, where they act as primary thermal sensors for detecting harmless and harmful (painful) temperatures.

[0004] It is becoming increasingly clear that TRP channel dysfunction is directly involved in the cause of disease of various hereditary and acquired diseases. In fact, both loss of function and gain of function mutations in TRP channel genes have been identified as direct causes of hereditary diseases, including brachyolmia, hypomagnesemia with secondary hypocalcemia, polycystic kidney disease, mucopolysaccharidosis type IV, and familial focal segmental glomerulosclerosis. In addition, TRP channel function / dysfunction has been directly related to a wide range of pathological conditions, including chronic pain, hypertension, cancer, epilepsy, and neurodegenerative disorders.

[0005] TRPM3 (transient receptor potential M-type 3) represents a promising pharmacological target. TRPM3 is expressed in a large subset of small-diameter sensory neurons from the dorsal root and trigeminal ganglion and is involved in heat sensing. The neurosteroid pregnenolone sulfate is an effective known activator of TRPM3 (Wagner et al., 2008). The neurosteroid pregnenolone sulfate induces pain in wild-type mice, but not in TRPM3 knockout mice. It has also been recently shown that CFA-induced inflammation and inflammatory pain are eliminated in TRPM3 knockout mice. Therefore, TRPM3 antagonists can be used as analgesics to combat pain, such as inflammatory pain (Vriens J. et al., Neuron, May 2011). TRPM3 is also expressed in many other tissues including the brain; reports show that two mutations in TRPM3 are associated with developmental and epileptic encephalopathy (Zhao, S. et al., Channels (Austin). 2021).

[0006] Some TRPM3 antagonists are known, but none of them point to the compounds of the present invention (Straub I et al., Mol Pharmacol, November 2013). For example, liquiritigenin, a putative TRPM3 blocker, has been described as reducing mechanical hyperalgesia and cold hyperalgesia in a rat pain model (Chen L et al., Scientific Reports, July 2014). There is still a huge medical need for novel, alternative and / or better therapeutic agents for preventing or treating TRPM3-mediated conditions (such as pain and epilepsy), more specifically for pain, such as inflammatory pain or epilepsy (such as epileptic encephalopathy). There is a great need for therapeutic agents with good efficacy, low levels or no side effects (such as the impossibility of addiction, non-toxicity like opioids) and / or good or better pharmacokinetic or kinetic properties for certain types of pain.

[0007] The present invention provides a novel class of compounds that are antagonists of TRPM3 and are useful as modulators of TRPM3-mediated disorders. Summary of the Invention

[0008] The first aspect of the present invention provides a compound of formula (I), its stereoisomeric form, physiologically acceptable salt, solvate and / or polymorph in R 1 Indicates -F, -Cl, -Br, -I, -CN, -R W 、-OR W、-OC(=O)R W 、-NR W R X 、-NR W C(=O)R X 、-SR W 、-S(=O)R W 、-S(=O)2R W 、-C(=O)R W 、-C(=O)OR W or -C(=O)NR W R X ; A means 3-14 membered cycloalkyl, which is saturated or unsaturated; unsubstituted, monosubstituted or polysubstituted; 6-14 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated; or 5-14 membered heteroaryl; which is in each case unsubstituted, replaced by R 2 monosubstituted or polysubstituted; Each R 2 independently selected from -F, -Cl, -Br, -I, -CN, -NO, -NO2, =O, =S, -SF5, -C(=O)-OH, -S(=O)2-OH, -R Y4 、-OR Y5 、-OC(=O)R Y5 、-NR Y5 R Z 、-NR Y5 C(=O)R Z 、-SR Y5 、-S(=O)R Y5 、-S(=O)2R Y5 、-NR Y5 S(=O)2R Z 、-C(=O)R Y5 、-C(=O)OR Y5 or -C(=O)NR Y5 R Z ; T represents -O-, and U represents -(CR 5 R 5 ') n -; or T represents -(CR 5 R 5 ') n -, and U represents -O-; n is an integer selected from 1, 2, 3, 4 or 5; R 5 and R 5 'Independently represent -RY4 ; R 6 、R 7 and R 8 independently represent -F, -Cl, -Br, -I, -CN, -NO2, -SF5, -R W 、-OR W 、-OC(=O)R W 、-NR W R X 、-NR W C(=O)R X 、-SR W 、-S(=O)R W 、-S(=O)2R W 、-C(=O)R W 、-C(=O)OR W or -C(=O)NR W R X ; W stands for 3-14 membered cycloalkyl, which is saturated or unsaturated; unsubstituted, monosubstituted or polysubstituted; 6-14 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 5-14 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; or -C1-C6-alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl; which are in each case unsubstituted, monosubstituted or polysubstituted; in R W and R X Independently of each other, expressed independently in each case -H; - C1-C6-alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C1-C6-heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 3-14 membered cycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; or 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered heterocycloalkyl is optionally linked via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; R Y4 、R Y5 and R Z Independently of each other, expressed independently in each case -H; - C1-C6-alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C1-C6-heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 3-14 membered cycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered heterocycloalkyl is optionally linked via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 6-14 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; wherein the 6-14 membered aryl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; or 5-14 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; wherein the 5-14 membered heteroaryl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; and wherein "mono- or polysubstituted" independently in each case means substituted by one or more substituents independently selected from the group consisting of: -F, -Cl, -Br, -I, -CN, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C 1-6 -alkylene-CF2H, -C 1-6 -alkylene-CFH2, -C 1-6 -alkylene-NH-C1-6 -alkylene-CF3, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-C 1-6 -alkyl, -C(=O)OH, -C 1-6 -alkylene-C(=O)-OH, -C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)-NH2, -C 1-6 -alkylene-C(=O)-NH2, -C(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -C(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -C(=O)-NH(OH), -C 1-6 -alkylene-C(=O)-NH(OH), -OH, -C 1-6 -alkylene-OH, =O, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -C 1-6 -alkylene-OC 1-6 -alkyl, -OC 1-6 -alkylene-OC 1-6 -alkyl, -OC 1-6 -alkylene-NH2, -OC 1-6 -alkylene-NH-C 1-6 -alkyl, -OC 1-6 -alkylene-N(C 1-6 -alkyl)2, -OC(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-OC(=O)-C 1-6 -alkyl, -OC(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-OC(=O)-OC 1-6 -alkyl, -OC(=O)-NH(C 1-6 -alkyl), -C1-6 -alkylene-OC(=O)-NH(C 1-6 -alkyl), -OC(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-OC(=O)-N(C 1-6 -alkyl)2, -OS(=O)2-NH2, -C 1-6 -alkylene-OS(=O)2-NH2, -OS(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-OS(=O)2-NH(C 1-6 -alkyl), -OS(=O)2-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-OS(=O)2-N(C 1-6 -alkyl)2, -NH2, -NO, -NO2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-NH-C(=O)-C 1-6 -alkyl, -NH-C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-NH-C(=O)-OC 1-6 -alkyl, -NH-C(=O)-NH2, -C 1-6 -alkylene-NH-C(=O)-NH2, -NH-C(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-NH-C(=O)-NH(C 1-6 -alkyl), -NH-C(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C(=O)-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -N(C 1-6-alkyl)-C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-NH2, -N(C 1-6 -alkyl)-C(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)-C(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-N(C 1-6 -alkyl)2, -NH-S(=O)2OH, -C 1-6 -alkylene-NH-S(=O)2OH, -NH-S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-OC 1-6 -alkyl, -C 1-6 -alkylene-NH-S(=O)2-OC 1-6 -alkyl, -NH-S(=O)2-NH2, -C 1-6 -alkylene-NH-S(=O)2-NH2, -NH-S(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-NH-S(=O)2-NH(C 1-6 -alkyl), -NH-S(=O)2N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-S(=O)2N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-S(=O)2-OH, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-OH, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-N(C1-6 -alkyl)-S(=O)2-C 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-NH2, -N(C 1-6 -alkyl)-S(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)-S(=O)2-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-N(C 1-6 -alkyl)2, -SH, =S, -SF5, -SCF3, -SCF2H, -SCFH2, -SC 1-6 -alkyl, -C 1-6 -alkylene-SC 1-6 -alkyl, -S(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-S(=O)-C 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-S(=O)2-C 1-6 -alkyl, -S(=O)2-OH, -C 1-6 -alkylene-S(=O)2-OH, -S(=O)2-OC 1-6 -alkyl, -C 1-6 -alkylene-S(=O)2-OC 1-6 -alkyl, -S(=O)2-NH2, -C 1-6 -alkylene-S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, -C 1-6-alkylene-S(=O)2-N(C 1-6 -alkyl) 2, 3-14 membered cycloalkyl, -C 1-6 -alkylene-(3-14 membered cycloalkyl), 3 to 14 membered heterocycloalkyl, -C 1-6 -alkylene-(3 to 14 membered heterocycloalkyl), -phenyl, -C 1-6 -alkylene-phenyl, 5- to 14-membered heteroaryl, -C 1-6 -alkylene-(5- to 14-membered heteroaryl), -O-(3- to 14-membered cycloalkyl), -O-(3- to 14-membered heterocycloalkyl), -O-phenyl, -O-(5- to 14-membered heteroaryl), -C(=O)-(3- to 14-membered cycloalkyl), -C(=O)-(3- to 14-membered heterocycloalkyl), -C(=O)-phenyl, -C(=O)-(5- to 14-membered heteroaryl), -S(=O)2-(3- to 14-membered cycloalkyl), -S(=O)2-(3- to 14-membered heterocycloalkyl), -S(=O)2-phenyl or -S(=O)2-(5- to 14-membered heteroaryl). Specifically, the present invention provides a compound of formula (I), its stereoisomeric forms, physiologically acceptable salts, solvates and / or polymorphs in R 1 Indicates -F, -Cl, -Br, -I, -CN, -R W 、-OR W 、-OC(=O)R W 、-NR W R X 、-NR W C(=O)R X 、-SR W 、-S(=O)R W 、-S(=O)2R W 、-C(=O)R W 、-C(=O)OR W or -C(=O)NR W R X ; A means 3-14 membered cycloalkyl, which is saturated or non-aromatically unsaturated; unsubstituted, monosubstituted or polysubstituted; 6-14 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated; or 5-14 membered heteroaryl; which in each case is unsubstituted, replaced by R 2 monosubstituted or polysubstituted; Each R 2independently selected from -F, -Cl, -Br, -I, -CN, -NO, -NO2, =O, =S, -SF5, -C(=O)-OH, -S(=O)2-OH, -R Y4 、-OR Y5 、-OC(=O)R Y5 、-NR Y5 R Z 、-NR Y5 C(=O)R Z 、-SR Y5 、-S(=O)R Y5 、-S(=O)2R Y5 、-NR Y5 S(=O)2R Z 、-C(=O)R Y5 、-C(=O)OR Y5 or -C(=O)NR Y5 R Z ; T represents -O-, and U represents -(CR 5 R 5 ') n -; or T represents -(CR 5 R 5 ') n -, and U represents -O-; n is an integer selected from 1, 2, 3, 4 or 5; R 5 and R 5 'Independently represent -R Y4 ; R 6 、R 7 and R 8 independently represent -F, -Cl, -Br, -I, -CN, -NO2, -SF5, -R W 、-OR W 、-OC(=O)R W 、-NR W R X 、-NR W C(=O)R X 、-SR W 、-S(=O)R W 、-S(=O)2R W 、-C(=O)R W 、-C(=O)OR W or -C(=O)NR W R X ; W stands for 3-14 membered cycloalkyl, which is saturated or non-aromatically unsaturated; unsubstituted, monosubstituted or polysubstituted; 6-14 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 5-14 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; or -C1-C6-alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl; which are in each case unsubstituted, monosubstituted or polysubstituted; in R W and R X Independently of each other, expressed independently in each case -H; - C1-C6-alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C1-C6-heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 3-14 membered cycloalkyl, which is saturated or non-aromatically unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally linked via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; or 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered heterocycloalkyl is optionally linked via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; R Y4 、R Y5 and R Z Independently of each other, expressed independently in each case -H; - C1-C6-alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C1-C6-heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 3-14 membered cycloalkyl, which is saturated or non-aromatically unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered heterocycloalkyl is optionally linked via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 6-14 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; wherein the 6-14 membered aryl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; or 5-14 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; wherein the 5-14 membered heteroaryl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; and wherein "mono- or polysubstituted" independently in each case means substituted by one or more substituents independently selected from the group consisting of: -F, -Cl, -Br, -I, -CN, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C 1-6 -alkylene-CF2H, -C 1-6 -alkylene-CFH2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-C 1-6 -alkyl, -C(=O)OH, -C 1-6 -alkylene-C(=O)-OH, -C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)-NH2, -C 1-6 -alkylene-C(=O)-NH2, -C(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -C(=O)-N(C 1-6-alkyl)2, -C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -C(=O)-NH(OH), -C 1-6 -alkylene-C(=O)-NH(OH), -OH, -C 1-6 -alkylene-OH, =O, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -C 1-6 -alkylene-OC 1-6 -alkyl, -OC 1-6 -alkylene-OC 1-6 -alkyl, -OC 1-6 -alkylene-NH2, -OC 1-6 -alkylene-NH-C 1-6 -alkyl, -OC 1-6 -alkylene-N(C 1-6 -alkyl)2, -OC(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-OC(=O)-C 1-6 -alkyl, -OC(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-OC(=O)-OC 1-6 -alkyl, -OC(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-OC(=O)-NH(C 1-6 -alkyl), -OC(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-OC(=O)-N(C 1-6 -alkyl)2, -OS(=O)2-NH2, -C 1-6 -alkylene-OS(=O)2-NH2, -OS(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-OS(=O)2-NH(C 1-6 -alkyl), -OS(=O)2-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-OS(=O)2-N(C 1-6 -alkyl)2, -NH2, -NO, -NO2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C1-6 -alkyl), -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-NH-C(=O)-C 1-6 -alkyl, -NH-C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-NH-C(=O)-OC 1-6 -alkyl, -NH-C(=O)-NH2, -C 1-6 -alkylene-NH-C(=O)-NH2, -NH-C(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-NH-C(=O)-NH(C 1-6 -alkyl), -NH-C(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C(=O)-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-NH2, -N(C 1-6 -alkyl)-C(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)-C(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-N(C 1-6-alkyl)2, -NH-S(=O)2OH, -C 1-6 -alkylene-NH-S(=O)2OH, -NH-S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-OC 1-6 -alkyl, -C 1-6 -alkylene-NH-S(=O)2-OC 1-6 -alkyl, -NH-S(=O)2-NH2, -C 1-6 -alkylene-NH-S(=O)2-NH2, -NH-S(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-NH-S(=O)2-NH(C 1-6 -alkyl), -NH-S(=O)2N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-S(=O)2N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-S(=O)2-OH, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-OH, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-NH2, -N(C 1-6 -alkyl)-S(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)-S(=O)2-N(C 1-6 -alkyl)2, -C1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-N(C 1-6 -alkyl)2, -SH, =S, -SF5, -SCF3, -SCF2H, -SCFH2, -SC 1-6 -alkyl, -C 1-6 -alkylene-SC 1-6 -alkyl, -S(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-S(=O)-C 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-S(=O)2-C 1-6 -alkyl, -S(=O)2-OH, -C 1-6 -alkylene-S(=O)2-OH, -S(=O)2-OC 1-6 -alkyl, -C 1-6 -alkylene-S(=O)2-OC 1-6 -alkyl, -S(=O)2-NH2, -C 1-6 -alkylene-S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-S(=O)2-N(C 1-6 -alkyl) 2, 3-14 membered cycloalkyl, -C 1-6 -alkylene-(3-14 membered cycloalkyl), 3 to 14 membered heterocycloalkyl, -C 1-6 -alkylene-(3 to 14 membered heterocycloalkyl), -phenyl, -C 1-6 -alkylene-phenyl, 5- to 14-membered heteroaryl, -C 1-6 -alkylene-(5- to 14-membered heteroaryl), -O-(3- to 14-membered cycloalkyl), -O-(3- to 14-membered heterocycloalkyl), -O-phenyl, -O-(5- to 14-membered heteroaryl), -C(═O)-(3- to 14-membered cycloalkyl), -C(═O)-(3- to 14-membered heterocycloalkyl), -C(═O)-phenyl, -C(═O)-(5- to 14-membered heteroaryl), -S(═O)2-(3- to 14-membered cycloalkyl), -S(═O)2-(3- to 14-membered heterocycloalkyl), -S(═O)2-phenyl, or -S(═O)2-(5- to 14-membered heteroaryl); When R 1 When it is hydrogen, A is not and wherein the compound is not:

[0009] A second aspect of the present invention encompasses a pharmaceutical composition comprising a compound of formula (I) as described in the first aspect.

[0010] According to a third aspect, the present invention also provides a compound of formula (I) as described in the first aspect or a pharmaceutical composition as described in the second aspect for use as a medicament.

[0011] According to a fourth aspect, the present invention also encompasses a compound of formula (I) as described in the first aspect or a pharmaceutical composition as described in the second aspect for use in preventing and / or treating a TRPM3-mediated disorder, in particular for preventing and / or treating pain, epilepsy and / or inflammatory hypersensitivity; and / or for combating pain, epilepsy and / or inflammatory hypersensitivity. Specifically for preventing and / or treating pain, epileptic encephalopathy and / or inflammatory hypersensitivity; and / or for combating pain, epileptic encephalopathy and / or inflammatory hypersensitivity.

[0012] The present invention also provides a method for preventing or treating a TRPM3-mediated disorder by administering a compound of formula (I) as described in the first aspect to a subject in need thereof. More specifically, the present invention relates to methods for preventing and / or treating pain, epilepsy, and / or inflammatory hypersensitivity; and / or for combating pain, epilepsy, and / or inflammatory hypersensitivity. More specifically, the present invention relates to methods for preventing and / or treating pain, epileptic encephalopathy, and / or inflammatory hypersensitivity; and / or for combating pain, epileptic encephalopathy, and / or inflammatory hypersensitivity.

[0013] The present invention further provides a method for preparing the compound of formula (I) as described in the first aspect, the method comprising the following steps: - converting a 5-O-substituted benzofuran-3-carboxylate derivative into its corresponding 5-O-substituted benzofuran-3-acetonitrile derivative, - The previously obtained 5-O substituted benzofuran-3-acetonitrile derivative is subjected to a cyclization to obtain the desired derivative of the present invention. DETAILED DESCRIPTION

[0014] Before describing the present invention, it should be understood that this invention is not limited to the particular processes, methods and compounds described, as such processes, methods and compounds may, of course, vary. It should also be understood that the terminology used herein is not intended to be limiting, as the scope of the present invention will be limited only by the appended claims.

[0015] When describing the compounds or processes of the present invention, the terms used are to be interpreted in accordance with the following definitions, unless the context indicates otherwise.

[0016] As used in the specification and the appended claims, the singular forms "a," "an," and "the" include both singular and plural referents unless the context clearly dictates otherwise. For example, "a compound" means one compound or more than one compound.

[0017] As used herein, the terms "comprising, comprises, and comprised of" are synonymous with "including, includes, or "containing, contains," and are inclusive or open-ended and do not exclude additional, unrecited members, elements, or method steps. The terms "comprising, comprises, and comprised of" also include the term "consisting of."

[0018] As used herein, the term "about" when referring to a measurable value such as a parameter, amount, time interval, etc., is intended to encompass variations of + / -10% or less, preferably + / -5% or less, more preferably + / -1% or less, and still more preferably + / -0.1% or less of the specified value, so long as such variations are suitable for performing the disclosed invention. It should be understood that the value to which the modifier "about" refers is itself also specifically and preferably disclosed.

[0019] As used herein, when the term "and / or" is used in conjunction with a list of two or more items, it means that any one of the listed items can be taken alone, or any combination of two or more of the listed items can be taken. For example, if a list is described as containing the group A, B, and / or C, the list can contain A alone; B alone; C alone; a combination of A and B; a combination of A and C; a combination of B and C; or a combination of A, B, and C.

[0020] The recitation of numerical ranges by endpoints includes all integers and, where appropriate, fractions within the range (e.g., 1 to 5 when referring to, for example, a plurality of elements, may include 1, 2, 3, 4, and when referring to, for example, a measurement, may also include 1.5, 2, 2.75, and 3.80). The recitation of endpoints also includes the endpoint values ​​themselves (e.g., 1.0 to 5.0 includes both 1.0 and 5.0). Any numerical range recited herein is intended to include all subranges subsumed therein.

[0021] References throughout this specification to "one embodiment" or "an embodiment" mean that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment of the present invention. Thus, the appearances of the phrases "in one embodiment" or "in an embodiment" in various places throughout this specification do not necessarily all refer to the same embodiment, but may. Furthermore, in one or more embodiments, the particular features, structures, or characteristics may be combined in any suitable manner, as will be apparent to those skilled in the art from this disclosure. Furthermore, while some embodiments described herein include some features included in other embodiments but not others, as will be understood by those skilled in the art, combinations of features from different embodiments are intended to be within the scope of the present invention and to form different embodiments. For example, in the following claims, any of the claimed embodiments may be used in any combination.

[0022] Similarly, it should be appreciated that in the description of exemplary embodiments of the invention, various features of the invention are sometimes grouped together in a single embodiment, figure, or description thereof for the purpose of simplifying the disclosure and aiding in understanding one or more of the various inventive aspects.

[0023] Unless otherwise defined, all terms (including technical and scientific terms) used in disclosing the present invention have the meaning commonly understood by one of ordinary skill in the art to which the present invention belongs. For further guidance, definitions of terms used in the specification are included to better understand the teachings of the present invention.

[0024] When describing the present invention, the terms used are to be interpreted in accordance with the following definitions, unless the context indicates otherwise.

[0025] The terms described above and other terms used in the specification can be well understood by those skilled in the art.

[0026] Whenever the term "substituted" is used herein, it is meant to indicate that one or more hydrogen atoms on the indicated atom in the expression using "substituted" is replaced with a selection from the indicated group, provided that the normal valency of the indicated atom is not exceeded and that the substitution results in a chemically stable compound, i.e., a compound sufficiently robust to survive isolation from a reaction mixture.

[0027] In each of the following definitions, the number of carbon atoms represents the maximum number of carbon atoms that is generally optimally present in a substituent or linker; it is understood that where otherwise indicated in this application, the number of carbon atoms represents the optimal maximum number of carbon atoms for that particular substituent or linker.

[0028] As used herein, the term "leaving group" or "LG" refers to a chemical group that is easily displaced or cleaved or hydrolyzed by a nucleophile under basic or acidic conditions. In a specific embodiment, the leaving group is selected from a halogen atom (e.g., Cl, Br, I) or a sulfonate (e.g., methanesulfonate, tosylate, triflate).

[0029] The term "protecting group" refers to a compound portion that masks or changes the properties of a functional group or the properties of the entire compound. The chemical substructure of a protecting group varies greatly. One function of a protecting group is to act as an intermediate in the synthesis of the parent drug substance. Chemical protecting groups and strategies for protection / deprotection are well known in the art. See: "Protective Groups in Organic Chemistry", Theodora W. Greene (John Wiley & Sons, Inc., New York), 1991. Protecting groups are typically used to mask the reactivity of certain functional groups to aid in the efficiency of desired chemical reactions, such as forming and breaking chemical bonds in an orderly and planned manner. Protection of a compound's functional groups changes other physical properties besides the reactivity of the protected functional group, such as polarity, lipophilicity (hydrophobicity), and other properties that can be measured by conventional analytical tools. Chemically protected intermediates themselves can be biologically active or inactive.

[0030] Protected compounds can also show changed, and in some cases optimized external and internal properties, such as by cell membrane and resistance to enzymatic degradation or chelation. In this effect, the protected compound with expected therapeutic effect can be referred to as prodrug. Another function of blocking group is that the parent drug is converted into prodrug, thus releasing the parent drug when converting the prodrug in vivo. Because active prodrug can be more effectively absorbed than the parent drug, prodrug can have a larger effect than the parent drug in vivo. In the case of chemical intermediates, blocking group is removed in vitro, or in the case of prodrug, blocking group is removed in vivo. For chemical intermediates, whether the resulting product (for example, alcohol) after deprotection is physiologically acceptable is not particularly important, although it is usually more desirable whether the product is pharmacologically harmless.

[0031] As used herein, the term "heteroatom" means an atom selected from the group consisting of nitrogen (which may be quaternized); oxygen; and sulfur (including sulfoxides and sulfones).

[0032] As used herein, the term "saturated or unsaturated alkyl" encompasses saturated alkyl groups as well as unsaturated alkyl groups such as alkenyl, alkynyl, and the like. Suitable examples of saturated or unsaturated alkyl groups include, but are not limited to, methyl, ethyl, 1-propyl (n-propyl), 2-propyl (iPr), 1-butyl, 2-methyl-1-propyl (i-Bu), 2-butyl (s-Bu), 2-dimethyl-2-propyl (t-Bu), 1-pentyl (n-pentyl), 2-pentyl, 3-pentyl, 2-methyl-2-butyl, 3-methyl-2-butyl, 3-methyl-1-butyl, 2-methyl-1-butyl, 1-hexyl, 2-hexyl, 3-hexyl, 2-methyl-2-pentyl, 3-methyl-2-pentyl, 4-methyl-2-pentyl, 3-methyl-3-pentyl, 2-methyl-3-pentyl, 2,3-dimethyl-2-butyl, and 3,3-dimethyl-2-butyl. "C 1-6 "Alkyl" includes all straight or branched chain alkyl groups having between 1 and 6 carbon atoms, and thus includes methyl, ethyl, n-propyl, isopropyl, butyl and isomers thereof (e.g., n-butyl, isobutyl and tert-butyl); pentyl and isomers thereof, hexyl and isomers thereof. For example, "C 1-5 "Alkyl" includes all straight or branched chain alkyl groups having between 1 and 5 carbon atoms, and thus includes methyl, ethyl, n-propyl, isopropyl, butyl and isomers thereof (e.g., n-butyl, isobutyl and tert-butyl); pentyl and isomers thereof; ethylene or vinyl (-CH=CH2), allyl (-CH2CH=CH2), 5-hexenyl (-CH2CH2CH2CH2CH=CH2); 2-butenyl, 3-butenyl, 2-pentenyl and isomers thereof, 2-hexenyl and isomers thereof, 2,4-pentadienyl, ethynyl, 2-propynyl, 2-butynyl, 3-butynyl, 2-pentynyl and chain isomers thereof, 2-hexynyl and chain isomers thereof.

[0033] As used herein, the term "alkyl" means a straight or branched normal, secondary or tertiary hydrocarbon with no sites of unsaturation. Examples are methyl, ethyl, 1-propyl (n-propyl), 2-propyl (iPr), 1-butyl, 2-methyl-1-propyl (i-Bu), 2-butyl (s-Bu), 2-dimethyl-2-propyl (t-Bu), 1-pentyl (n-pentyl), 2-pentyl, 3-pentyl, 2-methyl-2-butyl, 3-methyl-2-butyl, 3-methyl-1-butyl, 2-methyl-1-butyl, 1-hexyl, 2-hexyl, 3-hexyl, 2-methyl-2-pentyl, 3-methyl-2-pentyl, 4-methyl-2-pentyl, 3-methyl-3-pentyl, 2-methyl-3-pentyl, 2,3-dimethyl-2-butyl and 3,3-dimethyl-2-butyl. "C 1-6"Alkyl" includes all straight or branched chain alkyl groups having between 1 and 6 carbon atoms, and thus includes methyl, ethyl, n-propyl, isopropyl, butyl and isomers thereof (e.g., n-butyl, isobutyl and tert-butyl); pentyl and isomers thereof, hexyl and isomers thereof. For example, "C 1-5 "Alkyl" includes all straight or branched chain alkyl groups having between 1 and 5 carbon atoms, and thus includes methyl, ethyl, n-propyl, isopropyl, butyl and isomers thereof (e.g., n-butyl, isobutyl and tert-butyl); pentyl and isomers thereof. For example, "C 1-4 "Alkyl" includes all straight or branched chain alkyl groups having between 1 and 4 carbon atoms, and thus includes methyl, ethyl, n-propyl, isopropyl, butyl, and isomers thereof (e.g., n-butyl, isobutyl, and tert-butyl). For example, "C 1-3 "Alkyl" includes all straight or branched chain alkyl groups having between 1 and 3 carbon atoms, and thus includes methyl, ethyl, n-propyl, isopropyl. "Substituted C 1-6 "Alkyl" refers to a C substituted with one or more substituents (e.g., 1 to 3 substituents, e.g., 1, 2, or 3 substituents) at any available point of attachment. 1-6 alkyl.

[0034] As used herein, the term "alkenyl" means a straight or branched normal hydrocarbon, secondary hydrocarbon, or tertiary hydrocarbon having at least one site of unsaturation (usually 1 to 3, preferably 1), i.e., a carbon-carbon sp2 double bond. Examples include, but are not limited to, ethylene or vinyl (-CH=CH2), allyl (-CH2CH=CH2), and 5-hexenyl (-CH2CH2CH2CH2CH=CH2). The double bond can be in cis or trans configuration. When a subscript is used after a carbon atom herein, the subscript refers to the number of carbon atoms that the named group may contain. For example, the term "C 2-6 "Alkenyl" refers to an unsaturated hydrocarbon group that may be straight or branched, containing one or more carbon-carbon double bonds and containing 2 to 6 carbon atoms. For example, C 2-4 Alkenyl includes all straight-chain or branched alkenyl groups having 2 to 4 carbon atoms. 2-6 Examples of alkenyl groups are ethenyl, 2-propenyl, 2-butenyl, 3-butenyl, 2-pentenyl and its isomers, 2-hexenyl and its isomers, 2,4-pentadienyl and the like.

[0035] As used herein, the term "alkynyl" means a straight or branched normal hydrocarbon, secondary hydrocarbon, or tertiary hydrocarbon having at least one site of unsaturation (usually 1 to 3, preferably 1), i.e., a carbon-carbon sp triple bond. Examples include, but are not limited to, ethynyl (-C≡CH) and 1-propynyl (propargyl, -CH2C≡CH). When a subscript is used after a carbon atom, the subscript refers to the number of carbon atoms that the named group may contain. For example, the term "C 2-6 "Alkynyl" refers to an unsaturated hydrocarbon group that may be straight or branched, containing one or more carbon-carbon triple bonds and containing 2 to 6 carbon atoms. For example, C 2-4 Alkynyl includes all straight-chain or branched alkynyl groups having 2 to 4 carbon atoms. 2-6 Non-limiting examples of alkynyl groups include ethynyl, 2-propynyl, 2-butynyl, 3-butynyl, 2-pentynyl and chain isomers thereof, 2-hexynyl and chain isomers thereof, and the like.

[0036] As used herein, the term "saturated or unsaturated alkylene" encompasses saturated alkylene as well as unsaturated alkylene, such as alkenylene, alkynylene, alkenynylene, etc. As used herein, the term "alkylene" means a saturated, straight-chain or branched hydrocarbon radical having two monovalent radical centers derived by removing two hydrogen atoms from the same or two different carbon atoms of a parent alkane. Typical alkylene groups include, but are not limited to, methylene (-CH2-), ethylene (-CH2-CH2-), methylmethylene (-CH(CH3)-), 1-methyl-ethylene (-CH(CH3)-CH2-), n-propylene (-CH2-CH2-CH2-), 2-methylpropylene (-CH2-CH(CH3)-CH2-), 3-methylpropylene (-CH2-CH2-CH(CH3)-), n-butylene (-CH2-CH2-CH2-CH2-), 2-methylbutylene (-CH2-CH(CH3)-CH2-CH2-), 4-methylbutylene (-CH2-CH2-CH2-CH(CH3)-), pentylene and its chain isomers, hexylene and its chain isomers. As used herein, the term "alkenylene" means a straight or branched chain hydrocarbon radical having at least one site of unsaturation (usually 1 to 3, preferably 1), i.e., a carbon-carbon sp2 double bond, and having two monovalent radical centers derived by removing two hydrogen atoms from the same or two different carbon atoms of a parent alkene. 2-6 "Alkenylene" by itself or as part of another substituent refers to a divalent C 2-6 An alkenyl group, that is, has two single bonds to attach two other groups.

[0037] As used herein, the term "alkynylene" means a straight or branched chain hydrocarbon radical having at least one site of unsaturation (usually 1 to 3, preferably 1), i.e., a carbon-carbon sp triple bond, and having two monovalent radical centers derived by removing two hydrogen atoms from the same or two different carbon atoms of a parent alkyne. As used herein, the term "C 2-6 "Alkynylidene" by itself or as part of another substituent refers to a divalent C 2-6 Alkynyl groups, that is, have two single bonds to attach two other groups.

[0038] The term "alkenyl" as a group or part of a group refers to an unsaturated hydrocarbon group that may be straight or branched chain containing one or more carbon-carbon double bonds. When a subscript is used after a carbon atom herein, the subscript refers to the number of carbon atoms that the named group may contain. For example, the term "C 2-6 "Alkenyl" refers to an unsaturated hydrocarbon group that may be straight or branched, containing one or more carbon-carbon double bonds and containing 2 to 6 carbon atoms. For example, C 2-4 Alkenyl includes all straight-chain or branched alkenyl groups having 2 to 4 carbon atoms. 2-6 Examples of alkenyl groups are ethenyl, 2-propenyl, 2-butenyl, 3-butenyl, 2-pentenyl and its isomers, 2-hexenyl and its isomers, 2,4-pentadienyl and the like.

[0039] The term "alkynyl" by itself or as part of another substituent refers to an unsaturated hydrocarbon radical which may be straight or branched chain containing one or more carbon-carbon triple bonds. When a subscript is used herein after a carbon atom, the subscript refers to the number of carbon atoms the named group may contain. For example, the term "C 2-6 "Alkynyl" refers to an unsaturated hydrocarbon group that may be straight or branched, containing one or more carbon-carbon triple bonds and containing 2 to 6 carbon atoms. For example, C 2-4 Alkynyl includes all straight-chain or branched alkynyl groups having 2 to 4 carbon atoms. 2-6 Non-limiting examples of alkynyl groups include ethynyl, 2-propynyl, 2-butynyl, 3-butynyl, 2-pentynyl and chain isomers thereof, 2-hexynyl and chain isomers thereof, and the like.

[0040] The term "halogenated C 1-6 "Alkyl" as a group or part of a group refers to a C 1-6 Alkyl wherein one, two or three hydrogen atoms are each substituted by halogen as defined herein. Such halogenated C 1-6Non-limiting examples of alkyl groups include chloromethyl, 1-bromoethyl, fluoromethyl, difluoromethyl, trifluoromethyl, 1,1,1-trifluoroethyl, and the like.

[0041] As used herein, term " saturated or unsaturated heteroalkyl " covers saturated heteroalkyl and unsaturated heteroalkyl, such as heteroalkenyl, heteroalkynyl etc.As used herein, term " heteroalkyl " means straight or branched chain alkyl, wherein one or more carbon atoms (typically 1,2 or 3) are replaced by heteroatoms (that is, oxygen, nitrogen or sulphur atom), and condition is that the chain can be free of two adjacent O atoms or two adjacent S atoms.This means that one or more -CH of the alkyl can be replaced by -NH2 and / or one or more -CH of the alkyl - can be replaced by -NH-, -O- or -S-. The S atom in the chain can optionally be oxidized by one or two oxygen atoms to provide sulfoxide and sulfone respectively. In addition, the heteroalkyl in the compound of the present invention can contain oxo or thio group at any carbon or heteroatom, which will produce stable compound. Exemplary heteroalkyl includes but is not limited to alcohol, alkyl ether (such as -methoxy, -ethoxy, -butoxy ...), primary alkylamine, secondary alkylamine and tertiary alkylamine, amides, ketones, esters, alkyl sulfide and alkyl sulfone. The term "heteroalkenyl" means a straight or branched chain alkenyl group in which one or more carbon atoms (typically 1, 2, or 3) are replaced by oxygen, nitrogen, or sulfur atoms, provided that the chain may not contain two adjacent O atoms or two adjacent S atoms. Thus, the term heteroalkenyl includes imine, -O-alkenyl, -NH-alkenyl, -N(alkenyl), -N(alkyl)(alkenyl), and -S-alkenyl. As used herein, the term "heteroalkynyl" means a straight or branched chain alkynyl group in which one or more carbon atoms (typically 1, 2, or 3) are replaced by oxygen, nitrogen, or sulfur atoms, provided that the chain may not contain two adjacent O atoms or two adjacent S atoms. Thus, the term heteroalkynyl includes -cyano, -O-alkynyl, -NH-alkynyl, -N(alkynyl), -N(alkyl)(alkynyl), -N(alkenyl)(alkynyl), and -S-alkynyl.

[0042] As used herein, the term "saturated or unsaturated heteroalkylene" encompasses saturated heteroalkylene and unsaturated heteroalkylene, such as heteroalkenylene, heteroalkynylene, etc. As used herein, the term "heteroalkylene" means a straight or branched chain alkylene group in which one or more carbon atoms (typically 1, 2, or 3) are replaced by a heteroatom (i.e., an oxygen, nitrogen, or sulfur atom), provided that the chain may not contain two adjacent O atoms or two adjacent S atoms. As used herein, the term "heteroalkenylene" means a straight or branched chain alkenylene group in which one or more carbon atoms (typically 1, 2, or 3) are replaced by an oxygen, nitrogen, or sulfur atom, provided that the chain may not contain two adjacent O atoms or two adjacent S atoms. As used herein, the term "heteroalkynylene" means a straight or branched chain alkynylene group in which one or more carbon atoms (typically 1, 2, or 3) are replaced by an oxygen, nitrogen, or sulfur atom, provided that the chain may not contain two adjacent O atoms or two adjacent S atoms.

[0043] As used herein, the term "saturated or unsaturated cycloalkyl" encompasses saturated cycloalkyl and unsaturated cycloalkyl, such as cycloalkenyl, cycloalkynyl, etc. Specifically, as used herein, the term "saturated or unsaturated cycloalkyl" encompasses saturated cycloalkyl and unsaturated non-aromatic cycloalkyl, such as cycloalkenyl and cycloalkynyl. Specifically, the terms "saturated or unsaturated cycloalkyl" and "saturated or non-aromatic unsaturated cycloalkyl" are synonymous. The term "saturated or unsaturated cycloalkyl" also includes all saturated and unsaturated hydrocarbon groups containing one or more rings, including monocyclic or bicyclic groups. The additional rings of the polycyclic cycloalkyl can be fused, bridged and / or joined by one or more spiro atoms. Suitable examples of saturated or unsaturated cycloalkyl groups include, but are not limited to, cyclopropyl, cyclopropenyl, cyclobutyl, cyclobutenyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cycloheptenyl, cyclooctyl, cyclooctenyl, 1,3-cyclohexadienyl, 1,4-cyclohexadienyl, 1,5-cyclooctadienyl, bicyclo[2.2.1]hept-2-yl, (1S,4R)-norbornan-2-yl, (1R,4R)-norbornan-3-yl, (1S,4S)-norbornan-2-yl, (1R,4S)-norbornan-2-yl, decalinyl, adamantyl, spiro[3.3]hept-2-yl, 3-bicyclo[3.1.0]hexanyl. Unless otherwise indicated, as used herein, the term "cycloalkyl" means a saturated cyclic hydrocarbon group, including monocyclic or bicyclic groups; the other rings of polycyclic cycloalkyl groups can be fused, bridged and / or connected by one or more spiro atoms. Examples of cycloalkyl groups include, for example, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, norbornyl, fenchyl, decalinyl, adamantyl, spiro [3.3] hept-2-yl, 3-bicyclo [3.1.0] hexane, etc. As used herein, the term "cycloalkenyl" means a non-aromatic cyclic hydrocarbon group having at least one unsaturated site (usually 1 to 3, preferably 1), i.e., a carbon-carbon sp2 double bond. The term "cycloalkenyl" also includes monocyclic or bicyclic groups; the other rings of polycyclic cycloalkenyl groups can be fused, bridged and / or connected by one or more spiro atoms. Examples include, but are not limited to, cyclopentenyl and cyclohexenyl. The double bond can be a cis or trans configuration. As used herein, the term "cycloalkynyl" means a non-aromatic cyclic hydrocarbon radical having at least one site of unsaturation (usually 1 to 3, preferably 1), i.e., a carbon-carbon sp triplet. An example is cyclohept-1-yne. A fused system of a cycloalkyl ring and a heterocycloalkyl ring is considered to be a heterocycloalkyl, regardless of the ring bound to the core structure. A fused system of a cycloalkyl ring and an aryl ring is considered to be an aryl, regardless of the ring bound to the core structure. A fused system of a cycloalkyl ring and a heteroaryl ring is considered to be a heteroaryl, regardless of the ring bound to the core structure.

[0044] As used herein, the term "saturated or unsaturated heterocycloalkyl" encompasses saturated heterocycloalkyl and unsaturated non-aromatic heterocycloalkyl groups comprising at least one heteroatom, i.e., N, O, or S as a ring member. Specifically, the terms "saturated or unsaturated heterocycloalkyl" and "saturated or non-aromatic unsaturated heterocycloalkyl" are synonymous. Unless otherwise indicated, as used herein, the term "heterocycloalkyl" means a "cycloalkyl" in which one or more carbon atoms (typically 1, 2, or 3) are replaced by oxygen, nitrogen, or sulfur atoms, provided that the chain may not contain two adjacent O atoms or two adjacent S atoms. Unless otherwise indicated, as used herein, the term "heterocycloalkenyl" means a "cycloalkenyl" in which one or more carbon atoms (typically 1, 2, or 3) are replaced by oxygen, nitrogen, or sulfur atoms, provided that the chain may not contain two adjacent O atoms or two adjacent S atoms. Unless otherwise indicated, as used herein, the term "heterocycloalkynyl" means a "cycloalkynyl" group in which one or more carbon atoms (typically 1, 2, or 3) are replaced by oxygen, nitrogen, or sulfur atoms, provided that the chain may not contain two adjacent O atoms or two adjacent S atoms. Examples of saturated and unsaturated heterocycloalkyl groups include, but are not limited to, azepane, 1,4-oxazepane, azetane, azetidine, aziridine, azocane, diazepane, dioxane, dioxolane, dithiane, dithiolane, imidazolidine, isothiazolidine, isoxazolidine, morpholine, oxazolidine, oxetane, oxetane, oxirane, piperazine, piperidine, pyrazolidine, pyrrolidine, quinuclidine, tetrahydrofuran, tetrahydropyran, tetrahydrothiopyran,

[0015] In some embodiments, the present invention includes but is not limited to thiophene, thiazolyl thiophene, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolidine, thiapyrrolAdditional heterocycloalkyl groups within the meaning of the present invention are described in Paquette, Leo A., Principles of Modern Heterocyclic Chemistry (WA Benjamin, New York, 1968), in particular Chapters 1, 3, 4, 6, 7, and 9; The Chemistry of Heterocyclic Compounds, A series of Monographs (John Wiley & Sons, New York, 1950 to present), in particular Volumes 13, 14, 16, 19, and 28; Katritzky, Alan R., Rees, CW, and Scriven, E., Comprehensive Heterocyclic Chemistry (Pergamon Press, 1996); and J. Am. Chem. Soc. (1960) 82:5566. When a heterocycloalkyl group does not contain nitrogen as a ring member, it is typically bonded through a carbon. When a heterocycloalkyl group contains nitrogen as a ring member, it may be bonded through either nitrogen or carbon. A system of a heterocycloalkyl ring fused to a cycloalkyl ring is considered a heterocycloalkyl group, regardless of the ring to which it is attached. A system of a heterocycloalkyl ring fused to an aryl ring is considered a heterocycloalkyl group, regardless of the ring to which it is attached. A system of a heterocycloalkyl ring fused to a heteroaryl ring is considered a heteroaryl group, regardless of the ring to which it is attached.

[0045] As used herein, the term "aryl" means an aromatic hydrocarbon. Typical aryl groups include, but are not limited to, one ring or two or three rings fused together, groups derived from benzene, naphthalene, anthracene, biphenyl, etc. The fused system of an aryl ring and a cycloalkyl ring is considered to be an aryl group, regardless of the ring that is combined with the core structure. The fused system of an aryl ring and a heterocycloalkyl ring is considered to be a heterocycloalkyl group, regardless of the ring that is combined with the core structure. Therefore, indoline, dihydrobenzofuran, dihydrobenzothiophene, etc. are considered to be heterocycloalkyl groups according to the present invention. The fused system of an aryl ring and a heteroaryl ring is considered to be a heteroaryl group, regardless of the ring that is combined with the core structure.

[0046] As used herein, the term "heteroaryl" means an aromatic ring system that includes at least one heteroatom (i.e., N, O, or S) as a ring member of the aromatic ring system. Examples of heteroaryl groups include, but are not limited to, benzimidazole, benzisoxazole, benzoxazole, benzodioxole, benzofuran, benzothiadiazole, benzothiazole, benzothiophene, carbazole, cinnoline, dibenzofuran, furan, furazan, imidazole, imidazopyridine, indazole, indole, indolizine, isobenzofuran, isoindole, isoquinoline, isothiazole, isoxazole, naphthyridine, oxadiazole, oxazole, oxindole, phthalazine, purine, pyrazine, pyrazole, pyridazine, pyridine, pyrimidine, pyrrole, quinazoline, quinoline, quinoxaline, tetrazole, thiadiazole, thiazole, thiophene, triazine, triazole, and [1,2,4]triazolo[4,3-a]pyrimidine.

[0047] By way of further example, the carbon-bonded heterocycle is bonded at position 2, 3, 4, 5, or 6 of a pyridine, at position 3, 4, 5, or 6 of a pyridazine, at position 2, 4, 5, or 6 of a pyrimidine, at position 2, 3, 5, or 6 of a pyrazine, at position 2, 3, 4, or 5 of a furan, tetrahydrofuran, thiophene, pyrrole, or tetrahydropyrrole, at position 2, 4, or 5 of an oxazole, imidazole, or thiazole, at position 3, 4, or 5 of an isoxazole, pyrazole, or isothiazole, at position 2 or 3 of an aziridine, at position 2, 3, or 4 of an azetidine, at position 2, 3, 4, 5, 6, 7, or 8 of a quinoline, or at position 1, 3, 4, 5, 6, 7, or 8 of an isoquinoline.

[0048] Preferred carbon-bonded heterocycles include 2-pyridyl, 3-pyridyl, 4-pyridyl, 5-pyridyl, 6-pyridyl, 3-pyridazinyl, 4-pyridazinyl, 5-pyridazinyl, 6-pyridazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 6-pyrimidinyl, 2-pyrazinyl, 3-pyrazinyl, 5-pyrazinyl, 6-pyrazinyl, 2-thiazolyl, 4-thiazolyl, or 5-thiazolyl. For example, nitrogen-bonded heterocycles are bonded to aziridine, azetidine, pyrrole, pyrrolidine, 2-pyrroline, 3-pyrroline, imidazole, imidazolidine, 2-imidazoline, 3-imidazoline, pyrazole, pyrazoline, 2-pyrazoline, 3-pyrazoline, piperidine, piperazine, indole, indoline, 1H-indazole at position 1, isoindole or isoindoline at position 2, morpholine at position 4, and carbazole or β-carboline at position 9. Preferred nitrogen-bonded heterocycles include 1-aziridine, 1-azetidinyl, 1-pyrrolyl, 1-imidazolyl, 1-pyrazolyl, and 1-piperidinyl. Additional heteroaryl groups within the meaning of the present invention are described in Paquette, Leo A., Principles of Modern Heterocyclic Chemistry (W.A. Benjamin Publishers, New York, 1968), in particular Chapters 1, 3, 4, 6, 7, and 9; in The Chemistry of Heterocyclic Compounds: A Series of Monographs (John Wiley & Sons, New York, 1950 to present), in particular Volumes 13, 14, 16, 19, and 28; Katritzky, Alan R., Rees, C.W., and Scriven, E., Comprehensive Heterocyclic Chemistry (Pergamon Publishers, 1996); and in Journal of the American Chemical Society (1960) 82:5566.

[0049] As used herein with respect to substituents, and unless otherwise indicated, the terms "monosubstituted," "disubstituted," "trisubstituted," "polysubstituted," and the like refer to chemical structures as defined herein wherein the corresponding moiety is substituted with one or more substituents, meaning that one or more hydrogen atoms of the moiety are each independently replaced with a substituent. For example, -C 1-6 -alkyl covers -CH2F, -CHF2, -CF3, -CH2CF3, CF2CF3, etc. Likewise, -C may be polysubstituted with substituents independently selected from -F and -Cl. 1-6 -Alkyl covers -CH2F, -CHF2, -CF3, -CH2CF3, CF2CF3, -CH2Cl, -CHCl2, -CCl3, -CH2CCl3, CCl2CCl3, -CHClF, -CClF2, -CCl2CF3, -CF2CCl3, -CClFCCl2F, etc. The name of any substituent found in more than one site in the compounds of the invention should be selected independently.

[0050] Unless otherwise indicated, as used herein, the term "solvate" includes any combination that can be formed between a derivative of the present invention and a suitable inorganic solvent (e.g., hydrate) or an organic solvent (such as, but not limited to, alcohols, ketones, esters, ethers, nitriles, etc.).

[0051] As used herein, the term "subject" refers to an animal, including a human, preferably a mammal, most preferably a human, that has been the object of treatment, observation or experiment.

[0052] As used herein, the term "therapeutically effective amount" means that amount of an active compound or agent that elicits the biological or medical response in a tissue system, animal or human that is being sought by the researcher, veterinarian, medical doctor or other clinician, including alleviation or partial alleviation of the symptoms of the disease or condition being treated.

[0053] As used herein, the term "composition" is intended to encompass a product comprising the specified ingredients in therapeutically effective amounts, as well as any product which results, directly or indirectly, from combination of the specified ingredients in the specified amounts.

[0054] As used herein, the term "antagonist" or "inhibitor" refers to a compound that can produce a functional antagonistic effect on the TRPM3 ion channel, including competitive antagonists, non-competitive antagonists, desensitizing agonists and partial agonists.

[0055] For the purposes of the present invention, the term "TRPM3-modulated" is used to refer to conditions that are affected by modulation of the TRPM3 ion channel, including states mediated by the TRPM3 ion channel.

[0056] As used herein, the term "TRPM3-mediated disorder" refers to a disorder or disease that can be prevented, treated, (partially) alleviated or improved using an antagonist of TRPM3, as well as symptoms and pain and inflammatory hypersensitivity symptoms. According to the International Association for the Study of Pain and for the purposes of the present invention, pain is an unpleasant sensation and emotional experience associated with actual or potential tissue damage, or is described in terms of such damage. Preferably, the disorder mediated by TRPM3 is pain or epilepsy. Preferably, the disorder mediated by TRPM3 is epilepsy, and the epilepsy is preferably selected from epileptic encephalopathy. For the purposes of the present invention, the term "epileptic encephalopathy" refers to a group of severe epilepsy characterized by epileptic seizures and encephalopathy. Preferably, the disorder mediated by TRPM3 is pain, and the pain is preferably selected from nociceptive pain, inflammatory pain and neuropathic pain. More preferably, pain is postoperative pain. For the purposes of the present invention, the term "inflammatory hypersensitivity" is used to refer to a condition characterized by one or more hallmarks of inflammation (including edema, erythema, hyperthermia, and pain) and / or an exaggerated physiological or pathophysiological response to one or more types of stimuli (including thermal, mechanical, and / or chemical stimuli).

[0057] The invention will be further described and in some cases with respect to specific embodiments but the invention is not limited thereto.

[0058] Preferred claims (features) and embodiments of the compounds and methods of the present invention are now set forth. Each claim and embodiment of the present invention, as so defined, may be combined with any other claim and / or embodiment, unless expressly indicated to the contrary. Specifically, any feature indicated as preferred or advantageous may be combined with any one or more other features indicated as preferred or advantageous.

[0059] The numbered claims of this invention are: 1. A compound of formula (I), its stereoisomeric form, physiologically acceptable salt, solvate and / or polymorph in R 1 Indicates -F, -Cl, -Br, -I, -CN, -R W 、-OR W 、-OC(=O)R W 、-NR W R X 、-NR W C(=O)R X 、-SR W 、-S(=O)R W、-S(=O)2R W 、-C(=O)R W 、-C(=O)OR W or -C(=O)NR W R X ; A means 3-14 membered cycloalkyl, which is saturated or unsaturated; unsubstituted, monosubstituted or polysubstituted, specifically 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, monosubstituted or polysubstituted; 6-14 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated; or 5-14 membered heteroaryl; which is in each case unsubstituted, replaced by R 2 monosubstituted or polysubstituted; Each R 2 independently selected from -F, -Cl, -Br, -I, -CN, -NO, -NO2, =O, =S, -SF5, -C(=O)-OH, -S(=O)2-OH, -R Y4 、-OR Y5 、-OC(=O)R Y5 、-NR Y5 R Z 、-NR Y5 C(=O)R Z 、-SR Y5 、-S(=O)R Y5 、-S(=O)2R Y5 、-NR Y5 S(=O)2R Z 、-C(=O)R Y5 、-C(=O)OR Y5 or -C(=O)NR Y5 R Z ; T represents -O-, and U represents -(CR 5 R 5 ') n -; or T represents -(CR 5 R 5 ') n -, and U represents -O-; n is an integer selected from 1, 2, 3, 4 or 5; R 5 and R 5 'Independently represent -R Y4 ; R6 、R 7 and R 8 independently represent -F, -Cl, -Br, -I, -CN, -NO2, -SF5, -R W 、-OR W 、-OC(=O)R W 、-NR W R X 、-NR W C(=O)R X 、-SR W 、-S(=O)R W 、-S(=O)2R W 、-C(=O)R W 、-C(=O)OR W or -C(=O)NR W R X ; W stands for 3-14 membered cycloalkyl, which is saturated or unsaturated; unsubstituted, monosubstituted or polysubstituted, specifically 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, monosubstituted or polysubstituted; 6-14 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 5-14 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; or -C1-C6-alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl; which are in each case unsubstituted, monosubstituted or polysubstituted; in R W and R X Independently of each other, expressed independently in each case -H; - C1-C6-alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C1-C6-heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 3-14 membered cycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted, specifically 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; or 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered heterocycloalkyl is optionally linked via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; R Y4 、R Y5 and R Z Independently of each other, expressed independently in each case -H; - C1-C6-alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C1-C6-heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 3-14 membered cycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted, specifically 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered heterocycloalkyl is optionally linked via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 6-14 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; wherein the 6-14 membered aryl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; or 5-14 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; wherein the 5-14 membered heteroaryl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; and wherein "mono- or polysubstituted" independently in each case means substituted by one or more substituents independently selected from the group consisting of: -F, -Cl, -Br, -I, -CN, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C 1-6 -alkylene-CF2H, -C 1-6 -alkylene-CFH2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-C 1-6 -alkyl, -C(=O)OH, -C 1-6 -alkylene-C(=O)-OH, -C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)-NH2, -C 1-6 -alkylene-C(=O)-NH2, -C(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -C(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -C(=O)-NH(OH), -C 1-6 -alkylene-C(=O)-NH(OH), -OH, -C 1-6-alkylene-OH, =O, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -C 1-6 -alkylene-OC 1-6 -alkyl, -OC 1-6 -alkylene-OC 1-6 -alkyl, -OC 1-6 -alkylene-NH2, -OC 1-6 -alkylene-NH-C 1-6 -alkyl, -OC 1-6 -alkylene-N(C 1-6 -alkyl)2, -OC(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-OC(=O)-C 1-6 -alkyl, -OC(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-OC(=O)-OC 1-6 -alkyl, -OC(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-OC(=O)-NH(C 1-6 -alkyl), -OC(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-OC(=O)-N(C 1-6 -alkyl)2, -OS(=O)2-NH2, -C 1-6 -alkylene-OS(=O)2-NH2, -OS(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-OS(=O)2-NH(C 1-6 -alkyl), -OS(=O)2-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-OS(=O)2-N(C 1-6 -alkyl)2, -NH2, -NO, -NO2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -C 1-6-alkylene-NH-C(=O)-C 1-6 -alkyl, -NH-C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-NH-C(=O)-OC 1-6 -alkyl, -NH-C(=O)-NH2, -C 1-6 -alkylene-NH-C(=O)-NH2, -NH-C(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-NH-C(=O)-NH(C 1-6 -alkyl), -NH-C(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C(=O)-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-NH2, -N(C 1-6 -alkyl)-C(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)-C(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-N(C 1-6 -alkyl)2, -NH-S(=O)2OH, -C 1-6 -alkylene-NH-S(=O)2OH, -NH-S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-NH-S(=O)2-C 1-6-alkyl, -NH-S(=O)2-OC 1-6 -alkyl, -C 1-6 -alkylene-NH-S(=O)2-OC 1-6 -alkyl, -NH-S(=O)2-NH2, -C 1-6 -alkylene-NH-S(=O)2-NH2, -NH-S(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-NH-S(=O)2-NH(C 1-6 -alkyl), -NH-S(=O)2N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-S(=O)2N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-S(=O)2-OH, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-OH, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-NH2, -N(C 1-6 -alkyl)-S(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)-S(=O)2-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-N(C 1-6 -alkyl)2, -SH, =S, -SF5, -SCF3, -SCF2H, -SCFH2, -SC 1-6 -alkyl, -C1-6 -alkylene-SC 1-6 -alkyl, -S(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-S(=O)-C 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-S(=O)2-C 1-6 -alkyl, -S(=O)2-OH, -C 1-6 -alkylene-S(=O)2-OH, -S(=O)2-OC 1-6 -alkyl, -C 1-6 -alkylene-S(=O)2-OC 1-6 -alkyl, -S(=O)2-NH2, -C 1-6 -alkylene-S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-S(=O)2-N(C 1-6 -alkyl) 2, 3-14 membered cycloalkyl, -C 1-6 -alkylene-(3-14 membered cycloalkyl), 3 to 14 membered heterocycloalkyl, -C 1-6 -alkylene-(3 to 14 membered heterocycloalkyl), -phenyl, -C 1-6 -alkylene-phenyl, 5- to 14-membered heteroaryl, -C 1-6 -alkylene-(5- to 14-membered heteroaryl), -O-(3- to 14-membered cycloalkyl), -O-(3- to 14-membered heterocycloalkyl), -O-phenyl, -O-(5- to 14-membered heteroaryl), -C(═O)-(3- to 14-membered cycloalkyl), -C(═O)-(3- to 14-membered heterocycloalkyl), -C(═O)-phenyl, -C(═O)-(5- to 14-membered heteroaryl), -S(═O)2-(3- to 14-membered cycloalkyl), -S(═O)2-(3- to 14-membered heterocycloalkyl), -S(═O)2-phenyl, or -S(═O)2-(5- to 14-membered heteroaryl); Specifically, when R 1 When it is hydrogen, A is not and wherein the compound is not: 2. The compound according to claim 1, wherein T represents -O-, and U represents -(CR5 R 5 ') n -. 3. A compound according to any of the preceding statements, wherein n is 1. 4. A compound according to any one of the preceding statements, wherein A represents 3-14 membered cycloalkyl, which is saturated or unsaturated; unsubstituted, monosubstituted or polysubstituted, specifically 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated; unsubstituted, monosubstituted or polysubstituted; 6-14 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated; or 5-14 membered heteroaryl; which is unsubstituted in each case, replaced by R 2 Mono-, di- or tri-substituted. 5. A compound according to any one of the preceding statements, wherein R 2 express -F, -Cl, -Br, -I, -CN, =O, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C 1-6 -alkylene-CF2H, -C 1-6 -alkylene-CFH2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, O-(3-14 membered cycloalkyl), -C 1-6 -alkylene-OC 1-6 -alkyl, -OC 1-6 -alkylene-NH2, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-C 1-6 -alkylene-C(=O)-NH2, -N(C 1-6 -alkyl)-C 1-6 -alkylene-C(=O)-NH-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-NH2, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C(=O)-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-OC 1-6 -alkyl, -SH, -C 1-6 -alkylene-SH, -SC 1-6 -alkyl, -S(=O)-C 1-6 -alkyl, -S(=O)2-C 1-6-alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-(6-14 membered aryl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-OH, -NH-S(=O)2-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkylene-NH2, -NH-S(=O)2-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-S(=O)2-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-NH2, -NH-S(=O)2-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-C 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)-NH2, -C(=O)-NH(C 1-6 -alkyl), 6. A compound according to any one of the preceding statements, wherein A represents 3-10 membered cycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted, disubstituted or trisubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CN, =O, -C 1-5 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OH, -C 1-5 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-5 -alkyl, -NH2, -C1-5 -alkylene-NH2, -NH(C 1-5 -alkyl), -N(3-8 membered cycloalkyl)(C 1-5 -alkyl), -C 1-5 -alkylene-NH(C 1-5 -alkyl), -N(C 1-5 -alkyl)2, -NH-C 1-5 -alkylene-C(=O)-NH2, 5-NH-C(=O)-C 1-5 -alkyl, -N(C 1-5 -alkyl)-C(=O)-C 1-5 -alkyl, -NH-C(=O)-C 1-5 -alkylene-OH, -NH-C(=O)-C 1-5 -alkylene-OC 1-5 -alkyl, -NH-C(=O)-C 1-5 -alkylene-NH2, -NH-C(=O)-C 1-5 -alkylene-NH(C 1-5 -alkyl), -NH-C(=O)-C 1-5 -alkylene-N(C 1-5 -alkyl)2, -S(=O)2-C 1-5 -alkyl, -NH-S(=O)2-C 1-5 -alkyl, -NH-S(=O)2-(3-8 membered cycloalkyl), -NH-S(=O)2-C 1-5 -alkylene-(3-8 membered cycloalkyl), -NH-S(=O)2-C 1-5 -alkylene-OH, -NH-S(=O)2-OC 1-5 -alkyl, -C(=O)-C 1-5 -alkyl, -C(=O)-OC 1-5 -alkyl, -C(=O)-NH2, in particular 3-10 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, mono-, di- or tri-substituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CN, =O, -C 1-5 -alkyl, -C 1-5 -Alkylene-CF3, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OH, -C 1-5 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-5 -alkyl, -NH2, -C 1-5 -alkylene-NH2, -NH(C 1-5-alkyl), -N(3-8 membered cycloalkyl)(C 1-5 -alkyl), -C 1-5 -alkylene-NH(C 1-5 -alkyl), -N(C 1-5 -alkyl)2, -NH-C 1-5 -alkylene-C(=O)-NH2, -NH-C(=O)-C 1-5 -alkyl, -N(C 1-5 -alkyl)-C(=O)-C 1-5 -alkyl, -NH-C(=O)-C 1-5 -alkylene-OH, -NH-C(=O)-C 1-5 -alkylene-OC 1-5 -alkyl, -NH-C(=O)-C 1-5 -alkylene-NH2, -NH-C(=O)-C 1-5 -alkylene-NH(C 1-5 -alkyl), -NH-C(=O)-C 1-5 -alkylene-N(C 1-5 -alkyl)2, -S(=O)2-C 1-5 -alkyl, -NH-S(=O)2-C 1-5 -alkyl, -NH-S(=O)2-(3-8 membered cycloalkyl), -NH-S(=O)2-C 1-5 -alkylene-(3-8 membered cycloalkyl), -NH-S(=O)2-C 1-5 -alkylene-OH, -NH-S(=O)2-OC 1-5 -alkyl, -C(=O)-C 1-5 -alkyl, -C(=O)-OC 1-5 -alkyl, -C(=O)-NH2; in particular 3-10 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, mono-, di- or tri-substituted by substituents independently selected from the group consisting of -F, -Cl, -Br, -I, -CN, =O, -C 1-5 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OH, -C 1-5 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-5 -alkyl, -NH2, -C 1-5 -alkylene-NH2, -NH(C 1-5 -alkyl), -N(3-8 membered cycloalkyl)(C 1-5 -alkyl), -C 1-5 -alkylene-NH(C1-5 -alkyl), -N(C 1-5 -alkyl)2, -NH-C 1-5 -alkylene-C(=O)-NH2, 5-NH-C(=O)-C 1-5 -alkyl, -N(C 1-5 -alkyl)-C(=O)-C 1-5 -alkyl, -NH-C(=O)-C 1-5 -alkylene-OH, -NH-C(=O)-C 1-5 -alkylene-OC 1-5 -alkyl, -NH-C(=O)-C 1-5 -alkylene-NH2, -NH-C(=O)-C 1-5 -alkylene-NH(C 1-5 -alkyl), -NH-C(=O)-C 1-5 -alkylene-N(C 1-5 -alkyl)2, -S(=O)2-C 1-5 -alkyl, -NH-S(=O)2-C 1-5 -alkyl, -NH-S(=O)2-(3-8 membered cycloalkyl), -NH-S(=O)2-C 1-5 -alkylene-(3-8 membered cycloalkyl), -NH-S(=O)2-C 1-5 -alkylene-OH, -NH-S(=O)2-OC 1-5 -alkyl, -C(=O)-C 1-5 -alkyl, -C(=O)-OC 1-5 -alkyl, -C(=O)-NH2; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted, disubstituted or trisubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CN, =O, -C 1-5 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OH, -C 1-5 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-5 -alkyl, -NH2, -C 1-5 -alkylene-NH2, -NH(C 1-5 -alkyl), -N(3-8 membered cycloalkyl)(C 1-5 -alkyl), -C 1-5 -alkylene-NH(C 1-5 -alkyl), -N(C 1-5 -alkyl)2, -NH-C 1-5-alkylene-C(=O)-NH2, 5-NH-C(=O)-C 1-5 -alkyl, -N(C 1-5 -alkyl)-C(=O)-C 1-5 -alkyl, -NH-C(=O)-C 1-5 -alkylene-OH, -NH-C(=O)-C 1-5 -alkylene-OC 1-5 -alkyl, -NH-C(=O)-C 1-5 -alkylene-NH2, -NH-C(=O)-C 1-5 -alkylene-NH(C 1-5 -alkyl), -NH-C(=O)-C 1-5 -alkylene-N(C 1-5 -alkyl)2, -S(=O)2-C 1-5 -alkyl, -NH-S(=O)2-C 1-5 -alkyl, -NH-S(=O)2-(3-8 membered cycloalkyl), -NH-S(=O)2-C 1-5 -alkylene-(3-8 membered cycloalkyl), -NH-S(=O)2-C 1-5 -alkylene-OH, -NH-S(=O)2-OC 1-5 -alkyl, -C(=O)-C 1-5 -alkyl, -C(=O)-OC 1-5 -alkyl, -C(=O)-NH2; in particular 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, mono-, di- or tri-substituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CN, =O, -C 1-5 -alkyl, -C 1-5 -Alkylene-CF3, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OH, -C 1-5 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-5 -alkyl, -NH2, -C 1-5 -alkylene-NH2, -NH(C 1-5 -alkyl), -N(3-8 membered cycloalkyl)(C 1-5 -alkyl), -C 1-5 -alkylene-NH(C 1-5 -alkyl), -N(C 1-5 -alkyl)2, -NH-C 1-5 -alkylene-C(=O)-NH2, -NH-C(=O)-C 1-5 -alkyl, -N(C1-5 -alkyl)-C(=O)-C 1-5 -alkyl, -NH-C(=O)-C 1-5 -alkylene-OH, -NH-C(=O)-C 1-5 -alkylene-OC 1-5 -alkyl, -NH-C(=O)-C 1-5 -alkylene-NH2, -NH-C(=O)-C 1-5 -alkylene-NH(C 1-5 -alkyl), -NH-C(=O)-C 1-5 -alkylene-N(C 1-5 -alkyl)2, -S(=O)2-C 1-5 -alkyl, -NH-S(=O)2-C 1-5 -alkyl, -NH-S(=O)2-(3-8 membered cycloalkyl), -NH-S(=O)2-C 1-5 -alkylene-(3-8 membered cycloalkyl), -NH-S(=O)2-C 1-5 -alkylene-OH, -NH-S(=O)2-OC 1-5 -alkyl, -C(=O)-C 1-5 -alkyl, -C(=O)-OC 1-5 -alkyl, -C(=O)-NH2; 5-14 membered heteroaryl, which is unsubstituted, monosubstituted, disubstituted or trisubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CN, =O, -C 1-5 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OH, -C 1-5 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-5 -alkyl, -NH2, -C 1-5 -alkylene-NH2, -NH(C 1-5 -alkyl), -N(3-8 membered cycloalkyl)(C 1-5 -alkyl), -C 1-5 -alkylene-NH(C 1-5 -alkyl), -N(C 1-5 -alkyl)2, -NH-C 1-5 -alkylene-C(=O)-NH2, 5-NH-C(=O)-C 1-5 -alkyl, -N(C 1-5 -alkyl)-C(=O)-C 1-5 -alkyl, -NH-C(=O)-C 1-5-alkylene-OH, -NH-C(=O)-C 1-5 -alkylene-OC 1-5 -alkyl, -NH-C(=O)-C 1-5 -alkylene-NH2, -NH-C(=O)-C 1-5 -alkylene-NH(C 1-5 -alkyl), -NH-C(=O)-C 1-5 -alkylene-N(C 1-5 -alkyl)2, -S(=O)2-C 1-5 -alkyl, -NH-S(=O)2-C 1-5 -alkyl, -NH-S(=O)2-(3-8 membered cycloalkyl), -NH-S(=O)2-C 1-5 -alkylene-(3-8 membered cycloalkyl), -NH-S(=O)2-C 1-5 -alkylene-OH, -NH-S(=O)2-OC 1-5 -alkyl, -C(=O)-C 1-5 -alkyl, -C(=O)-OC 1-5 -alkyl, -C(=O)-NH2; in particular 5-14 membered heteroaryl, which is unsubstituted, monosubstituted, disubstituted or trisubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CN, =O, -C 1-5 -alkyl, -C 1-5 -Alkylene-CF3, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OH, -C 1-5 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-5 -alkyl, -NH2, -C 1-5 -alkylene-NH2, -NH(C 1-5 -alkyl), -N(3-8 membered cycloalkyl)(C 1-5 -alkyl), -C 1-5 -alkylene-NH(C 1-5 -alkyl), -N(C 1-5 -alkyl)2, -NH-C 1-5 -alkylene-C(=O)-NH2, 5-NH-C(=O)-C 1-5 -alkyl, -N(C 1-5 -alkyl)-C(=O)-C 1-5 -alkyl, -NH-C(=O)-C 1-5 -alkylene-OH, -NH-C(=O)-C 1-5 -alkylene-OC 1-5-alkyl, -NH-C(=O)-C 1-5 -alkylene-NH2, -NH-C(=O)-C 1-5 -alkylene-NH(C 1-5 -alkyl), -NH-C(=O)-C 1-5 -alkylene-N(C 1-5 -alkyl)2, -S(=O)2-C 1-5 -alkyl, -NH-S(=O)2-C 1-5 -alkyl, -NH-S(=O)2-(3-8 membered cycloalkyl), -NH-S(=O)2-C 1-5 -alkylene-(3-8 membered cycloalkyl), -NH-S(=O)2-C 1-5 -alkylene-OH, -NH-S(=O)2-OC 1-5 -alkyl, -C(=O)-C 1-5 -alkyl, -C(=O)-OC 1-5 -alkyl, -C(=O)-NH2. 7. A compound according to any one of the preceding statements, wherein A represents 3-14 membered cycloalkyl selected from the group consisting of cyclopropyl, cyclopropenyl, cyclobutyl, cyclobutenyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cycloheptenyl, cyclooctyl, cyclooctenyl, 1,3-cyclohexadienyl, 1,4-cyclohexadienyl, 1,5-cyclooctadienyl, bicyclo[2.2.1]hept-2-yl, (1S,4R)-norbornan-2-yl, (1R,4R)-norbornan-2-yl, (1S,4S)-norbornan-2-yl, (1R,4S)-norbornan-2-yl, decalinyl, adamantyl, each of which is unsubstituted, replaced by R 2 monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl selected from the group consisting of azepane, 1,4-oxazepane, azetidine, azetidine, aziridine, azolane, diazepane, dioxane, dioxolane, dithiane, dithiolane, imidazolidine, isothiazolidine, isoxazolidine, morpholine, oxazolidine, oxazoline, isoxazoline, oxetane, oxetane, oxirane, piperazine, piperidine, pyrazolidine, pyrrolidine, quinuclidine, tetrahydrofuran, tetrahydropyran, tetrahydrothiopyran, thiazolidine, thietane, thio heterocyclopropane, thiolane, thiomorpholine, indoline, dihydrobenzofuran, dihydrobenzothiophene, 1,1-dioxothiocyclohexane, 2-azaspiro[3.3]heptane, 2-oxaspiro[3.3]heptane, 7-azaspiro[3.5]nonane, 8-azabicyclo[3.2.1]octane, 9-azabicyclo[3.3.1]nonane, hexahydro-1H-pyrrolazine, hexahydrocyclopenta[c]pyrrole, octahydrocyclopenta[c]pyrrole and octahydropyrrolo[1,2-a]pyrazine; which are in each case unsubstituted, replaced by R 2 monosubstituted or polysubstituted; -phenyl, which is unsubstituted, replaced by R 2 mono- or poly-substituted; or a 5-14 membered heteroaryl group selected from the group consisting of benzimidazole, benzisoxazole, benzoxazole, benzodioxole, benzofuran, benzothiadiazole, benzothiazole, benzothiophene, carbazole, cinnoline, dibenzofuran, furan, furazan, imidazole, imidazopyridine, indazole, indole, indolizine, isobenzofuran, isoindole, isoquinoline, isothiazole, isoxazole, naphthyridine, oxadiazole, oxazole, oxindole, phthalazine, purine, pyrazine, pyrazole, pyridazine, pyridine, pyrimidine, pyrrole, quinazoline, quinoline, quinoxaline, tetrazole, thiadiazole, thiazole, thiophene, triazine, triazole, and [1,2,4]triazolo[4,3-a]pyrimidine; each of which is unsubstituted, replaced by R 2 Monosubstituted or polysubstituted. 8. A compound according to any one of the preceding statements, wherein A represents 3-14 membered cycloalkyl selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, bicyclo[2.2.1]hept-2-yl, (1S,4R)-norbornan-2-yl, (1R,4R)-norbornan-2-yl, (1S,4S)-norbornan-2-yl, (1R,4S)-norbornan-2-yl, decalinyl, adamantyl, each of which is unsubstituted, replaced by R 2 monosubstituted, disubstituted or trisubstituted; a 3-14 membered heterocycloalkyl group selected from the group consisting of azepane, azetidine, diazepane, dioxane, dioxolane, dithiolane, imidazolidine, isothiazolidine, isoxazolidine, morpholine, oxazolidine, oxazoline, isoxazoline, oxirane, piperazine, piperidine, pyrazolidine, pyrrolidine, tetrahydrofuran, tetrahydropyran, tetrahydrothiopyran, thiazolidine, thiolane, thiomorpholine, indoline, dihydrobenzofuran, dihydrobenzo Thiophene, 1,1-dioxothiocyclohexane, 2-azaspiro[3.3]heptane, 2-oxaspiro[3.3]heptane, 7-azaspiro[3.5]nonane, 8-azabicyclo[3.2.1]octane, 9-azabicyclo[3.3.1]nonane, hexahydro-1H-pyrrolazine, hexahydrocyclopenta[c]pyrrole, octahydrocyclopenta[c]pyrrole and octahydropyrrolo[1,2-a]pyrazine; each of which is unsubstituted, replaced by R 2 monosubstituted or polysubstituted; -phenyl, which is unsubstituted, replaced by R 2 mono-, di- or tri-substituted; or a 5- to 14-membered heteroaryl group selected from the group consisting of benzimidazole, benzisoxazole, benzoxazole, benzodioxole, benzofuran, benzothiadiazole, benzothiazole, benzothiophene, carbazole, cinnoline, dibenzofuran, furan, furazan, imidazole, imidazopyridine, indazole, indole, indolizine, isobenzofuran, isoindole, isoquinoline, isothiazole, isoxazole, 1,2,3-oxadiazole, 1,2,4-oxadiazole, 1,2,5-oxadiazole, 1,3,4-oxadiazole, oxazole, oxindole, pyrazine, pyrazole, pyridazine, pyridine, pyrimidine, pyrrole, tetrazole, thiadiazole, thiazole, thiophene, triazine, triazole, and [1,2,4]triazolo[4,3-a]pyrimidine; each of which is unsubstituted, replaced by R 2 Mono-, di- or tri-substituted. 9. A compound according to any one of the preceding statements, wherein A represents 3- to 14-membered cycloalkyl selected from the group consisting of cyclopropyl, cyclopropenyl, cyclobutyl, cyclobutenyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cycloheptenyl, cyclooctyl, cyclooctenyl, 1,3-cyclohexadienyl, 1,4-cyclohexadienyl, 1,5-cyclooctadienyl, bicyclo[2.2.1]hept-2-yl, (1S,4R)-norbornan-2-yl, (1R,4R)-norbornan-2-yl, (1S,4S)-norbornan-2-yl, (1R,4S)-norbornan-2-yl, decalinyl, adamantyl, which are in each case unsubstituted, monosubstituted or polysubstituted, independently of one another, by substituents selected from the group consisting of -F, -Cl, -Br, -I, -CN, =O, -C 1-6-alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-5 -alkyl, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-OH, -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-C 1-6 -alkyl, -C(=O)-OC 1-6-alkyl, -C(=O)-NH2; specifically 3-14 membered cycloalkyl selected from the group consisting of cyclopropyl, cyclopropenyl, cyclobutyl, cyclobutenyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cycloheptenyl, cyclooctyl, cyclooctenyl, 1,3-cyclohexadienyl, 1,4-cyclohexadienyl, 1,5-cyclooctadienyl, bicyclo[2.2.1]hept-2-yl, (1S, 4R)-norbornan-2-yl, (1R,4R)-norbornan-2-yl, (1S,4S)-norbornan-2-yl, (1R,4S)-norbornan-2-yl, decalinyl, adamantyl, which are in each case unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CN, ═O, -C 1-6 -alkyl, -C 1-5 -Alkylene-CF3, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-5 -alkyl, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-C1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-OH, -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-C 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl, -C(=O)-NH2; 3-14 membered heterocycloalkyl selected from the group consisting of azepane, 1,4-oxazepane, azetidine, azetidine, aziridine, azoline, diazepane, dioxane, dioxolane, dithiane, dithiolane, imidazolidine, isothiazolidine, isoxazolidine, morpholine, oxazolidine, oxazoline, oxetane, oxetane, oxirane, piperazine, piperidine, pyrazolidine, pyrrolidine, quinuclidine, tetrahydrofuran, tetrahydropyran, tetrahydrothiopyran, thiazolidine, thietane, thiirane, thiolane, thiomorpholine, indoline, dihydrobenzofuran, dihydrobenzothiophene, 1,1-dioxothiocyclohexane, 2-azaspiro[3.3]heptane, 2-oxaspiro[3.3]heptane, 7-azaspiro[3.5]nonane, 8-azabicyclo[3.2.1]octane, 9-azabicyclo[3.3.1]nonane, hexahydro-1H-pyrrolazine, hexahydrocyclopenta[c]pyrrole, octahydrocyclopenta[c]pyrrole and octahydropyrrolo[1,2-a]pyrazine; which are in each case unsubstituted, monosubstituted or polysubstituted, independently of one another, by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CN, ═O, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-5 -alkyl, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6-alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-OH, -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-C 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl, -C(=O)-NH2; specifically 3-14 membered heterocycloalkyl, which is selected from the group consisting of azepane, 1,4-oxazepane, azetidine, azetidine, aziridine, azoccan, diazepane, dioxane, dioxolane, dithiane, dithiolane, imidazolidine, isothiazolidine, isoxazolidine, morpholine, oxazolidine, oxazoline, oxhexane, oxetane, oxetane, piperazine, piperidine, pyrazolidine, pyrrolidine, quinuclidine, tetrahydrofuran, tetrahydropyran, tetrahydrothiopyran, thiazolidine, thietane, thiirane, thiolane, thiomorpholine, indole phenoxy benzophenone, dihydrobenzofuran, dihydrobenzothiophene, 1,1-dioxothiocyclohexane, 2-azaspiro[3.3]heptane, 2-oxaspiro[3.3]heptane, 7-azaspiro[3.5]nonane, 8-azabicyclo[3.2.1]octane, 9-azabicyclo[3.3.1]nonane, hexahydro-1H-pyrrolazine, hexahydrocyclopenta[c]pyrrole, octahydrocyclopenta[c]pyrrole and octahydropyrrolo[1,2-a]pyrazine; which are in each case unsubstituted, monosubstituted or polysubstituted, independently of one another, by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CN, ═O, -C 1-6 -alkyl, -C 1-5 -Alkylene-CF3, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-5-alkyl, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-OH, -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-C 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl, -C(=O)-NH2; -phenyl, which is unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CN, =O, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-5 -alkyl, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-OH, -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-C 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl, -C(=O)-NH2; in particular phenyl, which is unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CN, =O, -C 1-6 -alkyl, -C 1-5 -Alkylene-CF3, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-5 -alkyl, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-OH, -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-C 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl, -C(=O)-NH2; or 5-14 membered heteroaryl selected from the group consisting of benzimidazole, benzisoxazole, benzoxazole, benzodioxole, benzofuran, benzothiadiazole, benzothiazole, benzothiophene, carbazole, cinnoline, dibenzofuran, furan, furazan, imidazole, imidazopyridine, indazole, indole, indolizine, isobenzofuran, isoindole, isoquinoline, isothiazole, isoxazole, naphthyridine, oxadiazole, oxazole, oxindole, Phthalidinyl, purine, pyrazine, pyrazole, pyridazine, pyridine, pyrimidine, pyrrole, quinazoline, quinoline, quinoxaline, tetrazole, thiadiazole, thiazole, thiophene, triazine, triazole and [1,2,4]triazolo[4,3-a]pyrimidine; which are in each case unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CN, =O, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-5-alkyl, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-OH, -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-C 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl, -C(=O)-NH2; specifically 5-14 membered heteroaryl, which is selected from the group consisting of benzimidazole, benzisoxazole, benzoxazole, benzodioxole, benzofuran, benzothiadiazole, benzothiazole, benzothiophene, carbazole, cinnoline, dibenzofuran, furan, furazan, imidazole, imidazopyridine, indazole, indole, indolizine, isobenzofuran, isoindole, isoquinoline, isothiazole, isoxazole, naphthyridine, oxadi ... benzothiophene, benzothiazole, benzothiophene, benzothiazole, benzothiophene, benzothiazole, benzothiophene, benzothiazole, benzothiophene, benzothiazole, benzothiophene, benzothiazole, benzothiophene, benzothiazole, benzothiophene, benzothiazole, benzothiazole, benzothiophene, benzothiazole, benzothiazole, benzothiophene, benzothiazole, benzothiazole, benzothiazole, benzothiophene, benzothiazole, benzothiazole, benzothiazole, benzothiazole, benzothiazole, benzothiazole, benzothiazole, benzothiazole, benzothiazole, benzothiazole, benzothiazole, benzothiazole, benzothiazole, oxazole, oxazole, oxindole, phthalazine, purine, pyrazine, pyrazole, pyridazine, pyridine, pyrimidine, pyrrole, quinazoline, quinoline, quinoxaline, tetrazole, thiadiazole, thiazole, thiophene, triazine, triazole and [1,2,4]triazolo[4,3-a]pyrimidine; which are in each case unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CN, ═O, -C1-6 -alkyl, -C 1-5 -Alkylene-CF3, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-5 -alkyl, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-OH, -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-C 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl, -C(=O)-NH2;. 10. A compound according to any one of the preceding statements, wherein R 1 express -H, -F, -Cl, -Br, -I, CN; -C 1-6- alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C1-C6-heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -OH; -OC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -NH2; -NHC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -N(C 1-6 -alkyl) 2, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -NHC(=O)C 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -NC 1-6 -alkylC(=O)C 1-6 - alkyl, which is in each case saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -SH; -SC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C(=O)C 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C(=O)OC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C(=O)NH2; -C(=O)NHC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C(=O)N(C 1-6 -alkyl) 2, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -S(=O)C 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -S(=O)2-C 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C1-C6-heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; or 3-14 membered cycloalkyl, which is saturated or non-aromatically unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered heterocycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted. 11. A compound according to any one of the preceding statements, wherein R 1 express -H, -F, -Cl, -Br, -I, CN; -C 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C1-C6-heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -OH; -OC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -NH2; -NHC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -N(C 1-6 -alkyl) 2, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -NHC(=O)C 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -NC 1-6 -alkylC(=O)C 1-6 - alkyl, which is in each case saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -SH; -SC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C(=O)C 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C(=O)OC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C(=O)NH2; -C(=O)NHC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C(=O)N(C 1-6 -alkyl) 2, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -S(=O)C 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -S(=O)2-C 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C1-C6-heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; or 3-14 membered saturated cycloalkyl, which is unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered saturated cycloalkyl is optionally linked via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered heterocycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted. 12. A compound according to any one of the preceding statements, wherein R 1 Indicates -H, -F, -Cl, -Br, -I, -CN, -C 1-6 -alkyl, -OC 1-6 -alkyl, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NH(C 1-6 -alkyl), -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C 1-6 -alkylene-CF2H, -C 1-6 -alkylene-CFH2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C1-6 -alkylene-CF3, -C(=O)C 1-6 -alkyl, -C(=O)OC 1-6 -alkyl, -C(=O)NH2; -C(=O)NHC 1-6 -alkyl, -C(=O)N(C 1-6 -alkyl)2, -S(=O)-C 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -OC 1-6 -alkyl, unsubstituted-cyclopropyl, unsubstituted cyclobutyl, unsubstituted cyclopentyl or unsubstituted cyclohexyl. 13. A compound according to any one of the preceding statements, wherein R 1 Indicates -H, -C 1-6 -alkyl, -C 1-6 -alkylene-OC 1-6 -alkyl, -CHF2, -CF3 or unsubstituted-cyclopentyl. 14. A compound according to any one of the preceding statements, wherein W represents 3-14 membered cycloalkyl, which is saturated or unsaturated; unsubstituted, monosubstituted or disubstituted, specifically 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated; unsubstituted, monosubstituted or disubstituted; 6-14 membered aryl, which is unsubstituted, monosubstituted or disubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated; unsubstituted, monosubstituted or disubstituted; 5-14 membered heteroaryl, which is unsubstituted, monosubstituted or disubstituted; or -C1-C6-alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl; which are in each case unsubstituted, monosubstituted or disubstituted. 15. A compound according to any one of the preceding statements, wherein W represents 3-14 membered saturated cycloalkyl, 5-14 membered cycloalkenyl, 8-14 membered cycloalkynyl, which are unsubstituted, monosubstituted or disubstituted; preferably 3-12 membered saturated cycloalkyl, 5-12 membered cycloalkenyl, 8-12 membered cycloalkynyl, which are unsubstituted, monosubstituted or disubstituted; preferably 3-10 membered saturated cycloalkyl, 5-10 membered cycloalkenyl, 8-10 membered cycloalkynyl, which are unsubstituted, monosubstituted or disubstituted; preferably 3-8 membered saturated cycloalkyl, 5-8 membered cycloalkenyl, 8 membered cycloalkynyl, which are unsubstituted, monosubstituted or disubstituted; 6-14 membered aryl, which is unsubstituted, monosubstituted or disubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated; unsubstituted, monosubstituted or disubstituted; 5-14 membered heteroaryl, which is unsubstituted, monosubstituted or disubstituted; or -C1-C6-alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl; which are in each case unsubstituted, monosubstituted or disubstituted. 16. A compound according to any one of the preceding statements, wherein W represents 3-14 membered cycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted independently by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6-alkyl) 2, 3-14 membered cycloalkyl, 3-14 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 14 membered heteroaryl, specifically 3-14 membered cycloalkyl, which is saturated or non-aromatically unsaturated, unsubstituted, monosubstituted or polysubstituted by substituents independently selected from the group consisting of: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, 3-14 membered cycloalkyl, 3-14 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 14 membered heteroaryl; 6-14 membered aryl, which is unsubstituted, independently selected from the following mono- or polysubstituted: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6-alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, 3-14 membered cycloalkyl, 3-14 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 14 membered heteroaryl; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, independently selected from the following mono- or polysubstituted: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, 3-14 membered cycloalkyl, 3-14 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 14 membered heteroaryl; 5-14 membered heteroaryl, which is unsubstituted, independently selected from the following mono- or polysubstituted: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6-alkyl, -NHC(=O)OC 1-6 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, 3-14 membered cycloalkyl, 3-14 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 14 membered heteroaryl; or -C1-C6-alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl; which are in each case unsubstituted, monosubstituted or polysubstituted independently by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6-alkyl), -S(=O)2-N(C 1-6 -alkyl)2, 3-14 membered cycloalkyl, 3-14 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 14 membered heteroaryl. 17. A compound according to any one of the preceding statements, wherein W represents 3-10 membered cycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted independently by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl) 2, 3-14 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 14 membered heteroaryl, specifically 3-10 membered cycloalkyl, which is saturated or non-aromatically unsaturated, unsubstituted, mono- or polysubstituted by substituents independently selected from the group consisting of: -F, -Cl, -Br, -I, -C 1-6-alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, 3-14 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 14 membered heteroaryl; or 6-12 membered aryl, which is unsubstituted, independently selected from the following mono- or polysubstituted: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, 3-14 membered cycloalkyl, 3-14 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 14 membered heteroaryl; 3-10 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, independently selected from the following mono- or polysubstituted: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, 3-14 membered cycloalkyl, 3-14 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 14 membered heteroaryl; 5-10 membered heteroaryl, which is unsubstituted, independently selected from the following mono- or polysubstituted: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6-alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, 3-14 membered cycloalkyl, 3-14 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 14 membered heteroaryl; or -C1-C6-alkyl, which is unsubstituted, monosubstituted or polysubstituted by substituents independently selected from the group consisting of: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, 3-14 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 14 membered heteroaryl. 18. A compound according to any one of the preceding statements, wherein W represents 3-10 membered cycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted, disubstituted or trisubstituted independently by substituents selected from the group consisting of: -F, -Cl, -Br, -C 1-5 -alkyl, -CF3, -CF2H, -CFH2, -C(=O)-C 1-5 -alkyl, -C(=O)OH, -C(=O)-OC 1-5 -alkyl, -OH, =O, -OC 1-5 -alkyl, -NH2, -NHC 1-5 -alkyl, -N(C 1-5 -alkyl)2, -C 1-5 -alkylene-NH2, -C 1-5 -alkylene-OH, -C 1-5 -alkylene-OC 1-5 -alkyl, -C 1-5 -alkylene-NHC(=O)OC 1-5 -alkyl, -NHC(=O)OC 1-5 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-5 -alkyl, -C(=O)-N(C 1-5 -alkyl)2, -S(=O)2C 1-5 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-5 -alkyl), 3-8 membered cycloalkyl, 3-10 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 10 membered heteroaryl, specifically 3-10 membered cycloalkyl, which is saturated or non-aromatically unsaturated, unsubstituted, mono-, di- or tri-substituted by substituents independently selected from: -F, -Cl, -Br, -C 1-5 -alkyl, -CF3, -CF2H, -CFH2, -C(=O)-C 1-5 -alkyl, -C(=O)OH, -C(=O)-OC 1-5 -alkyl, -OH, =O, -OC 1-5 -alkyl, -NH2, -NHC 1-5 -alkyl, -N(C 1-5 -alkyl)2, -C 1-5 -alkylene-NH2, -C 1-5 -alkylene-OH, -C 1-5 -alkylene-OC 1-5 -alkyl, -C 1-5 -alkylene-NHC(=O)OC 1-5 -alkyl, -NHC(=O)OC 1-5 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-5-alkyl, -C(=O)-N(C 1-5 -alkyl)2, -S(=O)2C 1-5 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-5 -alkyl), 3-8 membered cycloalkyl, 3-10 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 10 membered heteroaryl; 6-12 membered aryl groups which are unsubstituted, independently selected from the following mono-, di- or tri-substituted: -F, -Cl, -Br, -C 1-5 -alkyl, -CF3, -CF2H, -CFH2, -C(=O)-C 1-5 -alkyl, -C(=O)OH, -C(=O)-OC 1-5 -alkyl, -OH, =O, -OC 1-5 -alkyl, -NH2, -NHC 1-5 -alkyl, -N(C 1-5 -alkyl)2, -C 1-5 -alkylene-NH2, -C 1-5 -alkylene-OH, -C 1-5 -alkylene-OC 1-5 -alkyl, -C 1-5 -alkylene-NHC(=O)OC 1-5 -alkyl, -NHC(=O)OC 1-5 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-5 -alkyl, -C(=O)-N(C 1-5 -alkyl)2, -S(=O)2C 1-5 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-5 -alkyl), 3-8 membered cycloalkyl, 3-10 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 10 membered heteroaryl; 3-10 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, independently selected from the following mono-, di- or tri-substituted: -F, -Cl, -Br, -C 1-5 -alkyl, -CF3, -CF2H, -CFH2, -C(=O)-C 1-5 -alkyl, -C(=O)OH, -C(=O)-OC 1-5 -alkyl, -OH, =O, -OC 1-5 -alkyl, -NH2, -NHC 1-5 -alkyl, -N(C 1-5 -alkyl)2, -C 1-5 -alkylene-NH2, -C 1-5 -alkylene-OH, -C1-5 -alkylene-OC 1-5 -alkyl, -C 1-5 -alkylene-NHC(=O)OC 1-5 -alkyl, -NHC(=O)OC 1-5 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-5 -alkyl, -C(=O)-N(C 1-5 -alkyl)2, -S(=O)2C 1-5 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-5 -alkyl), 3-8 membered cycloalkyl, 3-10 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 10 membered heteroaryl; 5-10 membered heteroaryl, which is unsubstituted, independently selected from the following monosubstituted, disubstituted or trisubstituted: -F, -Cl, -Br, -C 1-5 -alkyl, -CF3, -CF2H, -CFH2, -C(=O)-C 1-5 -alkyl, -C(=O)OH, -C(=O)-OC 1-5 -alkyl, -OH, =O, -OC 1-5 -alkyl, -NH2, -NHC 1-5 -alkyl, -N(C 1-5 -alkyl)2, -C 1-5 -alkylene-NH2, -C 1-5 -alkylene-OH, -C 1-5 -alkylene-OC 1-5 -alkyl, -C 1-5 -alkylene-NHC(=O)OC 1-5 -alkyl, -NHC(=O)OC 1-5 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-5 -alkyl, -C(=O)-N(C 1-5 -alkyl)2, -S(=O)2C 1-5 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-5 -alkyl), 3-8 membered cycloalkyl, 3-10 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 10 membered heteroaryl; or -C1-C6-alkyl, which is unsubstituted, monosubstituted, disubstituted or trisubstituted independently by substituents selected from the group consisting of: -F, -Cl, -Br, -C 1-5 -alkyl, -CF3, -CF2H, -CFH2, -C(=O)-C 1-5 -alkyl, -C(=O)OH, -C(=O)-OC1-5 -alkyl, -OH, =O, -OC 1-5 -alkyl, -NH2, -NHC 1-5 -alkyl, -N(C 1-5 -alkyl)2, -C 1-5 -alkylene-NH2, -C 1-5 -alkylene-OH, -C 1-5 -alkylene-OC 1-5 -alkyl, -C 1-5 -alkylene-NHC(=O)OC 1-5 -alkyl, -NHC(=O)OC 1-5 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-5 -alkyl, -C(=O)-N(C 1-5 -alkyl)2, -S(=O)2C 1-5 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-5 -alkyl), 3-8 membered cycloalkyl, 3-10 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 10 membered heteroaryl. 19. A compound according to any one of the preceding statements, wherein W represents 3-14 membered cycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted independently by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -OH, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-OH, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6-alkyl) 2, specifically 3-14 membered cycloalkyl, which is saturated or non-aromatically unsaturated, unsubstituted, monosubstituted or polysubstituted independently by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -OH, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-OH, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, 6-14 membered aryl, which is unsubstituted, independently selected from the following mono- or polysubstituted: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -OH, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-OH, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6-alkyl)2; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, independently selected from the following mono- or polysubstituted: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -OH, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-OH, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2; 5-14 membered heteroaryl, which is unsubstituted, independently selected from the following mono- or polysubstituted: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -OH, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-OH, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6-alkyl)2; or -C1-C6-alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl; which are in each case unsubstituted, monosubstituted or polysubstituted independently by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -OH, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-OH, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2. 20. A compound according to any one of the preceding statements, wherein W represents 3-10 membered cycloalkyl, which is saturated, unsubstituted, monosubstituted or disubstituted independently by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -OH, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-OH, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6-alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, 6-14 membered aryl, which is unsubstituted, independently selected from the following mono- or polysubstituted: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -OH, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-OH, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2; 3-10 membered heterocycloalkyl, which is saturated, unsubstituted, mono- or di-substituted independently selected from: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -OH, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-OH, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6-alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2; 5-10 membered heteroaryl, which is unsubstituted, independently selected from the following mono- or di-substituted: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -OH, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-OH, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2; or -C1-C6-alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl; which are in each case unsubstituted, monosubstituted or disubstituted independently by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -OH, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-OH, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6-alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2. 21. A compound according to any of the preceding statements, wherein R 5 and R 5 'Independently express -H; - C1-C6-alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C1-C6-heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 3-14 membered cycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted, specifically 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted. 22. A compound according to any of the preceding statements, wherein n is an integer selected from 1, 2 or 3; and R 5 and R 5 'Independently express -H; - C1-C6-alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C1-C6-heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 3-14 membered cycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted, specifically 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted. 23. A compound according to any one of the preceding statements, wherein R 5 and R 5 ' independently of one another represent -H, -C1-C6-alkyl or -C1-C6-alkylene-N(C1-C6-alkyl)2. 24. A compound according to any of the preceding statements, wherein R 6 、R 7 and R 8 Independently express -H; -F, -Cl, -Br, -I, -OH, -SH, -SF5, -CN, -NO2, -C(=O)OH, -NH2; -C 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -OC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -NHC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -N(C 1-6 -alkyl) 2, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C(=O)OC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -OC(=O)C 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C 1-6 - heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted. 25. A compound according to any of the preceding statements, wherein R 6 、R 7 and R 8 Independently express -H, -F, -Cl, -Br, -I, -OH, -SH, -SF5, -CN, -NO2, -C(=O)OH, -NH2, -C 1-6 -alkyl, -CF3, -CHF2, -CH2F, -OC 1-6 -alkyl, -OCF3, -OCHF2, -OCH2F, -NHC 1-6-alkyl, which is unsubstituted or substituted by one or more substituents independently selected from the group consisting of: -OH, =O, -F, -Cl, -Br, -I, -SH, =S, -CN, -CF3, -CHF2, -CH2F, -OCF3, -OCHF2, -OCH2F, SF5, -NO2, -C(=O)OH, -NH2 and -C(=O)NH2; -N(C 1-6 -alkyl)2, which is unsubstituted or substituted by one or more substituents independently selected from the group consisting of: -OH, =O, -F, -Cl, -Br, -I, -SH, =S, -CN, -CF3, -CHF2, -CH2F, -OCF3, -OCHF2, -OCH2F, SF5, -NO2, -C(=O)OH, -NH2 and -C(=O)NH2; -C(=O)OC 1-6 -alkyl, which is unsubstituted or substituted by one or more substituents independently selected from the group consisting of: -OH, =O, -F, -Cl, -Br, -I, -SH, =S, -CN, -CF3, -CHF2, -CH2F, -OCF3, -OCHF2, -OCH2F, SF5, -NO2, -C(=O)OH, -NH2 and -C(=O)NH2; -OC(=O)C 1-6 -alkyl, which is unsubstituted or substituted by one or more substituents independently selected from the group consisting of: -OH, =O, -F, -Cl, -Br, -I, -SH, =S, -CN, -CF3, -CHF2, -CH2F, -OCF3, -OCHF2, -OCH2F, SF5, -NO2, -C(=O)OH, -NH2 and -C(=O)NH2; or -C 1-6 -heteroalkyl, which is unsubstituted or substituted by one or more substituents independently selected from the group consisting of: -OH, =O, -F, -Cl, -Br, -I, -SH, =S, -CN, -CF3, -CHF2, -CH2F, -OCF3, -OCHF2, -OCH2F, SF5, -NO2, -C(=O)OH, -NH2 and -C(=O)NH2. 26. A compound according to any of the preceding statements, wherein R 6 represents -H, -F, -Cl, -CN or -C1-C6-alkyl. 27. A compound according to any of the preceding statements, wherein R 6 -H is not indicated. 28. A compound according to any of the preceding statements, wherein R 7represents -H, -F, -Cl, -CN or -C1-C6-alkyl. 29. A compound according to any of the preceding statements, wherein R 7 -H is not indicated. 30. A compound according to any of the preceding statements, wherein R 8 represents -H, -F, -Cl, -CN or -C1-C6-alkyl. 31. A compound according to any of the preceding statements, wherein R 8 -H is not indicated. 32. A compound according to any of the preceding statements, wherein (i)R 6 、R 7 and R 8 each represents -H; or (ii)R 6 、R 7 and R 8 The two in the table represent -H, and R 6 、R 7 and R 8 The other of represents -F, -Cl, -CN or -CH3; or (iii)R 6 、R 7 and R 8 One of them represents -H, and R 6 、R 7 and R 8 The other of each independently represents -F, -Cl, -CN or -CH3. 33. A compound according to any of the preceding statements, selected from the group consisting of Cpd 001 to Cpd 028 as mentioned herein and physiologically acceptable salts thereof. 34. The compound according to any of the preceding statements, which is selected from the group consisting of Cpd 001 to Cpd 032 as mentioned herein and physiologically acceptable salts thereof. 35. A compound according to any of the preceding statements, wherein R 1 represents H, -CH3, -CH2F, -CHF2 or -CF3; T represents -O-, and U represents -(CR 5 R 5 ') n -; A means 3-14 membered cycloalkyl, which is saturated or unsaturated; unsubstituted, monosubstituted or polysubstituted, specifically 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated; unsubstituted, monosubstituted or polysubstituted; 6-14 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated; or 5-14 membered heteroaryl; which is in each case unsubstituted, replaced by R 2 monosubstituted, disubstituted or trisubstituted; Each R 2 independently selected from -F, -Cl, -Br, -I, -CN, -NO, -NO2, =O, -C(=O)-OH, -S(=O)2-OH, -R Y4 、-OR Y5 、-OC(=O)R Y5 、-NR Y5 R Z 、-NR Y5 C(=O)R Z 、-S(=O)2R Y5 、-NR Y5 S(=O)2R Z 、-C(=O)OR Y5 or -C(=O)NR Y5 R Z ; R 5 and R 5 'Independently represent -H, -C1-C6-alkyl or -C1-C6-alkylene-N(C1-C6-alkyl)2; R 6 、R 7 and R 8 independently of one another represent -H, -F, -Cl, -CN or -C1-C6-alkyl; W stands for 3-14 membered cycloalkyl, which is saturated or unsaturated; unsubstituted, monosubstituted or polysubstituted, specifically 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated; unsubstituted, monosubstituted or polysubstituted; 6-14 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, monosubstituted or polysubstituted; 5-14 membered heteroaryl, which is mono- or polysubstituted; or -C1-C6-alkyl; which is unsubstituted, monosubstituted or polysubstituted. 36. A compound according to any of the preceding statements, wherein R 1 represents H, -CH3, -CH2F, -CHF2 or -CF3; T represents -O-, and U represents -(CR 5 R 5 ') n -; A means 3-14 membered cycloalkyl, which is saturated or unsaturated; unsubstituted, monosubstituted or polysubstituted, specifically 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated; unsubstituted, monosubstituted or polysubstituted; 6-14 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated; or 5-14 membered heteroaryl; which is in each case unsubstituted, replaced by R 2 monosubstituted, disubstituted or trisubstituted; Each R 2 independently selected from -F, -Cl, -Br, -I, -CN, =O, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C 1-6 -alkylene-CF2H, -C 1-6 -alkylene-CFH2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, O-(3-14 membered cycloalkyl), -C 1-6 -alkylene-OC 1-6 -alkyl, -OC 1-6 -alkylene-NH2, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C 1-6-alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-C 1-6 -alkylene-C(=O)-NH2, -N(C 1-6 -alkyl)-C 1-6 -alkylene-C(=O)-NH-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-NH2, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C(=O)-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-OC 1-6 -alkyl, -SH, -C 1-6 -alkylene-SH, -SC 1-6-alkyl, -S(=O)-C 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-(6-14 membered aryl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-OH, -NH-S(=O)2-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkylene-NH2, -NH-S(=O)2-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-S(=O)2-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-NH2, -NH-S(=O)2-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-C 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)-NH2, -C(=O)-NH(C 1-6 -alkyl); R 5 and R 5 'Independently represent -H, -C1-C6-alkyl or -C1-C6-alkylene-N(C1-C6-alkyl)2; R 6 、R 7 and R 8 independently of one another represent -H, -F, -Cl, -CN or -C1-C6-alkyl; W stands for 3-14 membered cycloalkyl, which is saturated or unsaturated; unsubstituted, monosubstituted or polysubstituted, specifically 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated; unsubstituted, monosubstituted or polysubstituted; 6-14 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, monosubstituted or polysubstituted; 5-14 membered heteroaryl, which is mono- or polysubstituted; or -C1-C6-alkyl; which is unsubstituted, monosubstituted or polysubstituted. 37. A compound according to any of the preceding statements, wherein R 1 represents H, -CH3, -CH2F, -CHF2 or -CF3; T represents -O-, and U represents -(CR 5 R 5 ') n -; A means 3-14 membered saturated cycloalkyl, 5-14 membered cycloalkenyl, 8-14 membered cycloalkynyl; which are unsubstituted, monosubstituted or polysubstituted; 6-14 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated; or 5-14 membered heteroaryl; which is in each case unsubstituted, replaced by R 2 monosubstituted, disubstituted or trisubstituted; Each R 2 independently selected from -F, -Cl, -Br, -I, -CN, =O, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C 1-6 -alkylene-CF2H, -C 1-6 -alkylene-CFH2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, O-(3-14 membered cycloalkyl), -C 1-6 -alkylene-OC 1-6 -alkyl, -OC 1-6 -alkylene-NH2, -NH2, -C 1-6 -alkylene-NH2, -NH(C1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-C 1-6 -alkylene-C(=O)-NH2, -N(C 1-6 -alkyl)-C 1-6 -alkylene-C(=O)-NH-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-NH2, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-NH(C 1-6-alkyl), -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C(=O)-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-OC 1-6 -alkyl, -SH, -C 1-6 -alkylene-SH, -SC 1-6 -alkyl, -S(=O)-C 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-(6-14 membered aryl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-OH, -NH-S(=O)2-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkylene-NH2, -NH-S(=O)2-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-S(=O)2-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-NH2, -NH-S(=O)2-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-C 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)-NH2, -C(=O)-NH(C 1-6 -alkyl); R5 and R 5 'Independently represent -H, -C1-C6-alkyl or -C1-C6-alkylene-N(C1-C6-alkyl)2; R 6 、R 7 and R 8 independently of one another represent -H, -F, -Cl, -CN or -C1-C6-alkyl; W stands for 3-14 membered saturated cycloalkyl, 5-14 membered cycloalkenyl, 8-14 membered cycloalkynyl, each of which is unsubstituted, monosubstituted or polysubstituted; 6-14 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, monosubstituted or polysubstituted; 5-14 membered heteroaryl, which is mono- or polysubstituted; or -C1-C6-alkyl; which is unsubstituted, monosubstituted or polysubstituted. 38. A pharmaceutical composition or medicament comprising a compound according to any one of the preceding statements. 39. A compound according to any of the preceding statements or a pharmaceutical composition according to statement 38 for use as a medicament. 40. A compound according to any preceding statement or a pharmaceutical composition according to statement 38 for use in the treatment of pain or epilepsy; preferably, pain and epileptic encephalopathy. 41. The compound for use or pharmaceutical composition for use of statement 40, wherein the pain is selected from nociceptive pain, inflammatory pain, and neuropathic pain. 42. The compound for use or pharmaceutical composition for use of statement 41, wherein the pain is postoperative pain. 43. A method for preventing and / or treating a TRPM3-mediated disorder, the method comprising administering to a subject an effective amount of a compound according to any one of statements 1 to 37 or a pharmaceutical composition according to claim 38. 44. A method for preventing and / or treating pain or epilepsy; preferably pain and epileptic encephalopathy, the method comprising administering to a subject an effective amount of a compound according to any one of statements 1 to 37 or a pharmaceutical composition according to claim 38. 45. The method of statement 44 wherein the pain is selected from the group consisting of nociceptive pain, inflammatory pain, and neuropathic pain.

[0060] The first aspect of the present invention is to provide a compound of formula (I), its stereoisomeric form, physiologically acceptable salt, solvate and / or polymorph in R 1 Indicates -F, -Cl, -Br, -I, -CN, -R W 、-OR W 、-OC(=O)R W 、-NR W R X 、-NR W C(=O)R X 、-SR W 、-S(=O)R W 、-S(=O)2R W 、-C(=O)R W 、-C(=O)OR W or -C(=O)NR W R X ; A means 3-14 membered cycloalkyl, which is saturated or unsaturated; unsubstituted, monosubstituted or polysubstituted, specifically 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated; unsubstituted, monosubstituted or polysubstituted; 6-14 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated; or 5-14 membered heteroaryl; which is in each case unsubstituted, replaced by R 2 monosubstituted or polysubstituted; Each R 2 independently selected from -F, -Cl, -Br, -I, -CN, -NO, -NO2, =O, =S, -SF5, -C(=O)-OH, -S(=O)2-OH, -R Y4 、-OR Y5 、-OC(=O)R Y5 、-NR Y5 R Z 、-NR Y5 C(=O)R Z 、-SR Y5 、-S(=O)R Y5 、-S(=O)2R Y5 、-NR Y5 S(=O)2R Z 、-C(=O)R Y5 、-C(=O)ORY5 or -C(=O)NR Y5 R Z ; T represents -O-, and U represents -(CR 5 R 5 ') n -;or T stands for -(CR 5 R 5 ') n -, and U represents -O-; n is an integer selected from 1, 2, 3, 4 or 5; R 5 and R 5 'Independently represent -R Y4 ; R 6 、R 7 and R 8 independently represent -F, -Cl, -Br, -I, -CN, -NO2, -SF5, -R W 、-OR W 、-OC(=O)R W 、-NR W R X 、-NR W C(=O)R X 、-SR W 、-S(=O)R W 、-S(=O)2R W 、-C(=O)R W 、-C(=O)OR W or -C(=O)NR W R X ; W stands for 3-14 membered cycloalkyl, which is saturated or unsaturated; unsubstituted, monosubstituted or polysubstituted, specifically 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated; unsubstituted, monosubstituted or polysubstituted; 6-14 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 5-14 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; or -C1-C6-alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl; which are in each case unsubstituted, monosubstituted or polysubstituted; in R W and R X Independently of each other, expressed independently in each case -H; - C1-C6-alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C1-C6-heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 3-14 membered cycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted, specifically 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; or 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered heterocycloalkyl is optionally linked via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; R Y4 、R Y5 and R Z Independently of each other, expressed independently in each case -H; - C1-C6-alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C1-C6-heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 3-14 membered cycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted, specifically 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered heterocycloalkyl is optionally linked via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 6-14 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; wherein the 6-14 membered aryl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; or 5-14 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; wherein the 5-14 membered heteroaryl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; and wherein "mono- or polysubstituted" independently in each case means substituted by one or more substituents independently selected from the group consisting of: -F, -Cl, -Br, -I, -CN, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C 1-6 -alkylene-CF2H, -C 1-6 -alkylene-CFH2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-C 1-6 -alkyl, -C(=O)OH, -C 1-6 -alkylene-C(=O)-OH, -C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)-NH2, -C 1-6 -alkylene-C(=O)-NH2, -C(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -C(=O)-N(C 1-6-alkyl)2, -C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -C(=O)-NH(OH), -C 1-6 -alkylene-C(=O)-NH(OH), -OH, -C 1-6 -alkylene-OH, =O, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -C 1-6 -alkylene-OC 1-6 -alkyl, -OC 1-6 -alkylene-OC 1-6 -alkyl, -OC 1-6 -alkylene-NH2, -OC 1-6 -alkylene-NH-C 1-6 -alkyl, -OC 1-6 -alkylene-N(C 1-6 -alkyl)2, -OC(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-OC(=O)-C 1-6 -alkyl, -OC(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-OC(=O)-OC 1-6 -alkyl, -OC(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-OC(=O)-NH(C 1-6 -alkyl), -OC(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-OC(=O)-N(C 1-6 -alkyl)2, -OS(=O)2-NH2, -C 1-6 -alkylene-OS(=O)2-NH2, -OS(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-OS(=O)2-NH(C 1-6 -alkyl), -OS(=O)2-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-OS(=O)2-N(C 1-6 -alkyl)2, -NH2, -NO, -NO2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C1-6 -alkyl), -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-NH-C(=O)-C 1-6 -alkyl, -NH-C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-NH-C(=O)-OC 1-6 -alkyl, -NH-C(=O)-NH2, -C 1-6 -alkylene-NH-C(=O)-NH2, -NH-C(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-NH-C(=O)-NH(C 1-6 -alkyl), -NH-C(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C(=O)-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-NH2, -N(C 1-6 -alkyl)-C(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)-C(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-N(C 1-6-alkyl)2, -NH-S(=O)2OH, -C 1-6 -alkylene-NH-S(=O)2OH, -NH-S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-OC 1-6 -alkyl, -C 1-6 -alkylene-NH-S(=O)2-OC 1-6 -alkyl, -NH-S(=O)2-NH2, -C 1-6 -alkylene-NH-S(=O)2-NH2, -NH-S(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-NH-S(=O)2-NH(C 1-6 -alkyl), -NH-S(=O)2N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-S(=O)2N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-S(=O)2-OH, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-OH, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-NH2, -N(C 1-6 -alkyl)-S(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)-S(=O)2-N(C 1-6 -alkyl)2, -C1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-N(C 1-6 -alkyl)2, -SH, =S, -SF5, -SCF3, -SCF2H, -SCFH2, -SC 1-6 -alkyl, -C 1-6 -alkylene-SC 1-6 -alkyl, -S(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-S(=O)-C 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-S(=O)2-C 1-6 -alkyl, -S(=O)2-OH, -C 1-6 -alkylene-S(=O)2-OH, -S(=O)2-OC 1-6 -alkyl, -C 1-6 -alkylene-S(=O)2-OC 1-6 -alkyl, -S(=O)2-NH2, -C 1-6 -alkylene-S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-S(=O)2-N(C 1-6 -alkyl) 2, 3-14 membered cycloalkyl, -C 1-6 -alkylene-(3-14 membered cycloalkyl), 3 to 14 membered heterocycloalkyl, -C 1-6 -alkylene-(3 to 14 membered heterocycloalkyl), -phenyl, -C 1-6 -alkylene-phenyl, 5- to 14-membered heteroaryl, -C 1-6 -alkylene-(5- to 14-membered heteroaryl), -O-(3- to 14-membered cycloalkyl), -O-(3- to 14-membered heterocycloalkyl), -O-phenyl, -O-(5- to 14-membered heteroaryl), -C(═O)-(3- to 14-membered cycloalkyl), -C(═O)-(3- to 14-membered heterocycloalkyl), -C(═O)-phenyl, -C(═O)-(5- to 14-membered heteroaryl), -S(═O)2-(3- to 14-membered cycloalkyl), -S(═O)2-(3- to 14-membered heterocycloalkyl), -S(═O)2-phenyl, or -S(═O)2-(5- to 14-membered heteroaryl); Specifically, when R 1 When it is hydrogen, A is not and wherein the compound is not:

[0061] In some embodiments, T represents -O-, U represents -(CR 5 R 5 ') n -; and n is an integer selected from 1, 2 or 3.

[0062] In some embodiments, R 1 express -H, -F, -Cl, -Br, -I, CN; -C 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C1-C6-heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -OH; -OC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -NH2; -NHC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -N(C 1-6 -alkyl) 2, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -NHC(=O)C 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -NC 1-6 -alkylC(=O)C 1-6 - alkyl, which is in each case saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -SH; -SC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C(=O)C 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C(=O)OC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C(=O)NH2; -C(=O)NHC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C(=O)N(C 1-6 -alkyl) 2, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -S(=O)C 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -S(=O)2-C 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C1-C6-heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; or 3-14 membered cycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted, specifically 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered heterocycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted.

[0063] In some embodiments, R 1 express -H, -F, -Cl, -Br, -I, CN; -C 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C1-C6-heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -OH; -OC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -NH2; -NHC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -N(C 1-6-alkyl) 2, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -NHC(=O)C 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -NC 1-6 -alkylC(=O)C 1-6 - alkyl, which is in each case saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -SH; -SC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C(=O)C 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C(=O)OC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C(=O)NH2; -C(=O)NHC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C(=O)N(C 1-6 -alkyl) 2, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -S(=O)C 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -S(=O)2-C 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C1-C6-heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; or 3-14 membered saturated cycloalkyl, 5-14 membered cycloalkenyl, 8-14 membered cycloalkynyl, which are unsubstituted, monosubstituted or polysubstituted; wherein each of the 3-14 membered cycloalkyl, 5-14 membered cycloalkenyl, 8-14 membered cycloalkynyl is optionally linked through -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered heterocycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted. In some embodiments, R 1 express -H, -F, -Cl, -Br, -I, CN; -C 1-6 -alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl, which are in each case unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl; -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2; -C1-C6-heteroalkyl, which is unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6-alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl; -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2; -OH; -OC 1-6 -alkyl, -O-C2-C6-alkenyl, -O-C2-C6-alkynyl, which are in each case unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6-alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl; -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2; -NH2; -NHC 1-6 -alkyl, which is unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6-alkyl, -NHC(=O)OC 1-6 -alkyl; -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2; -N(C 1-6 -alkyl) 2, which is in each case unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl; -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2; -NHC(=O)C 1-6-alkyl, which is unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl; -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2; -NC 1-6 -alkylC(=O)C 1-6 -alkyl, which is in each case unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl; -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2; -SH; -SC 1-6 -alkyl, -S-C2-C6-alkenyl, -S-C2-C6-alkynyl, which are in each case unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6-alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl; -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2; -C(=O)C 1-6 -alkyl, which is unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl; -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6-alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2; -C(=O)OC 1-6 -alkyl, which is unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl; -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2; -C(=O)NH2; -C(=O)NHC 1-6-alkyl, which is unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl; -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2; -C(=O)N(C 1-6 -alkyl) 2, which is in each case unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6-alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl; -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2; -S(=O)C 1-6 -alkyl, which is unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl; -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2; -S(=O)2-C 1-6 -alkyl, which is unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl; -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2; -C1-C6-heteroalkyl, which is unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl; -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2; or 3-14 membered cycloalkyl, which is unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally linked via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6-alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl; -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered heterocycloalkyl is optionally linked via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted, unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6-alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl; -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2.

[0064] In some embodiments, R 1 Indicates -H, -F, -Cl, -Br, -I, -CN, -C 1-6 -alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl, -OH, -OC 1-6 -alkyl, -SH, -NH2, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NH(C 1-6 -alkyl), -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C 1-6 -alkylene-CF2H, -C 1-6 -alkylene-CFH2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C 1-6 -alkylene-CF3, -C(=O)C 1-6 -alkyl, -C(=O)OC1-6 -alkyl, -C(=O)NH2, -C(=O)NHC 1-6 -alkyl, -C(=O)N(C 1-6 -alkyl)2, -S(=O)-C 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -OC 1-6 -alkyl, unsubstituted 3-14 membered cycloalkyl or unsubstituted 3-14 membered heterocycloalkyl. 1 Indicates -H, -F, -Cl, -Br, -I, CN, -C 1-6 -alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl, -OH, -OC 1-6 -alkyl, -SH, -NH2, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NH(C 1-6 -alkyl), -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C 1-6 -alkylene-CF2H, -C 1-6 -alkylene-CFH2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C 1-6 -alkylene-CF3, -C(=O)C 1-6 -alkyl, -C(=O)OC 1-6 -alkyl, -C(=O)NH2, -C(=O)NHC 1-6 -alkyl, -C(=O)N(C 1-6 -alkyl)2, -S(=O)-C 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -OC 1-6 -alkyl, unsubstituted-cyclopropyl, unsubstituted cyclobutyl, unsubstituted cyclopentyl or unsubstituted cyclohexyl.

[0065] In some embodiments, R 1 Indicates -H, CN, -C 1-6 -alkyl, -C 1-6 -alkylene-OC 1-6-alkyl, -CH2F, -CHF2, -CF3, -C(=O)NH2, unsubstituted-cyclopropyl, unsubstituted cyclobutyl, unsubstituted cyclopentyl or unsubstituted cyclohexyl. Preferably, R 1 represents -H, -CH2F, -CHF2, -CF3, -C(=O)NH2, -CN, unsubstituted-cyclopropyl, unsubstituted cyclobutyl, unsubstituted cyclopentyl or unsubstituted cyclohexyl. Preferably, R 1 Indicates H, -C 1-6 -alkyl, -C(=O)NH2, -CHF2, unsubstituted-cyclopropyl, unsubstituted cyclobutyl, unsubstituted cyclopentyl or unsubstituted cyclohexyl.

[0066] Preferably, R 1 Indicates -H, -CN, -C 1-3 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-3 -alkylene-CF3, -C 1-3 -alkylene-CF2H, -C(=O)NH2 or -C 1-3 -alkylene-CFH2; more specifically -H, -CH3 or -CF2H,.

[0067] In some embodiments, A represents 3-14 membered cycloalkyl, wherein the 3-14 membered cycloalkyl is selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl, each of which is saturated or unsaturated, each of which is unsubstituted, and R 2 monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, wherein the 3-14 membered heterocycloalkyl is selected from the group consisting of azepane, 1,4-oxazepane, azetidine, aziridine, azocane, diazepane, dioxane, dioxolane, dithiane, dithiolane, imidazolidine, isothiazolidine, isoxazolidine, morpholine, oxazoline, oxazolidine, oxhexane, oxetane, oxirane, piperazine, piperidine, pyrazolidine, pyrrolidine, quinuclidine, tetrahydrofuran, tetrahydropyran, tetrahydrothiopyran, thiazolidine, thietane alkyl, thiirane, thiolane, thiomorpholine, indoline, dihydrobenzofuran, dihydrobenzothiophene, 1,1-dioxothiocyclohexane, 2-azaspiro[3.3]heptane, 2-oxaspiro[3.3]heptane, 7-azaspiro[3.5]nonane, 8-azabicyclo[3.2.1]octane, 9-azabicyclo[3.3.1]nonane, hexahydro-1H-pyrrolazine, hexahydrocyclopenta[c]pyrrole, octahydrocyclopenta[c]pyrrole and octahydropyrrolo[1,2-a]pyrazine; which are in each case unsubstituted, replaced by R2 monosubstituted or polysubstituted; -phenyl, which is unsubstituted, replaced by R 2 monosubstituted or polysubstituted; 5-14 membered heteroaryl, wherein the 5-14 membered heteroaryl is selected from the group consisting of benzimidazole, benzisoxazole, benzoxazole, benzofuran, benzothiadiazole, benzothiazole, benzothiophene, carbazole, cinnoline, dibenzofuran, furan, furazan, imidazole, imidazopyridine, indazole, indole, indolizine, isobenzofuran, isoindole, isoquinoline, isothiazole, isoxazole, naphthyridine, oxadiazole, oxazole, oxindole, phthalazine, purine, pyrazine, pyrazole, pyridazine, pyridine, pyrimidine, pyrrole, quinazoline, quinoline, quinoxaline, tetrazole, thiadiazole, thiazole, thiophene, triazine, triazole and [1,2,4]triazolo[4,3-a]pyrimidine; which is unsubstituted, substituted or replaced by R 2 Monosubstituted or polysubstituted.

[0068] In some embodiments, A represents 3-14 membered cycloalkyl, wherein the 3-14 membered cycloalkyl is selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl, which are in each case saturated or unsaturated, which are in each case unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of -F, -Cl, -Br, -CN, =O, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -N(C1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -SH, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl-C(=O)-NH2; 3-14 membered heterocycloalkyl, wherein the 3-14 membered heterocycloalkyl is selected from the group consisting of azepane, 1,4-oxazepane, azetidine, aziridine, azocane, diazepane, dioxane, dioxolane, dithiane, dithiolane, imidazolidine, isothiazolidine, isoxazolidine, morpholine, oxazoline, oxazolidine, oxhexane, oxetane, oxetane, piperazine, piperidine, pyrazolidine, pyrrolidine, quinuclidine, tetrahydrofuran, tetrahydropyran, tetrahydrothiopyran, thiazolidine, thietane, thiirane, thiolane, thiomorpholine, indoline, dihydrobenzofuran, dihydrobenzothiophene, 1,1-dioxothiocyclohexane, 2-azaspiro[3.3]heptane, 2-oxaspiro[3.3]heptane, 7-azaspiro[3.5]nonane, 8-azabicyclo[3.2.1]octane, 9-azabicyclo[3.3.1]nonane, hexahydro-1H-pyrrolazine, hexahydrocyclopenta[c]pyrrole, octahydrocyclopenta[c]pyrrole and octahydropyrrolo[1,2-a]pyrazine; which are in each case unsubstituted, monosubstituted or polysubstituted, independently of one another, by substituents selected from the group consisting of: -F, -Cl, -Br, -CN, ═O, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -NH2, -C 1-6-alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -SH, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl-C(=O)-NH2; -phenyl, which is unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -CN, =O, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6-alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -SH, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl-C(=O)-NH2; 5-14 membered heteroaryl, wherein the 5-14 membered heteroaryl is in each case selected from the group consisting of benzimidazole, benzisoxazole, benzoxazole, benzofuran, benzothiadiazole, benzothiazole, benzothiophene, carbazole, cinnoline, dibenzofuran, furan, furazan, imidazole, imidazopyridine, indazole, indole, indolizine, isobenzofuran, isoindole, isoquinoline, isothiazole, isoxazole, naphthyridine, oxadiazole, oxazole , oxindole, phthalazine, purine, pyrazine, pyrazole, pyridazine, pyridine, pyrimidine, pyrrole, quinazoline, quinoline, quinoxaline, tetrazole, thiadiazole, thiazole, thiophene, triazine, triazole and [1,2,4]triazolo[4,3-a]pyrimidine; which are in each case unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -CN, ═O, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6-alkyl)2, -SH, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl-C(=O)-NH2.

[0069] In some embodiments, A represents 3-14 membered cycloalkyl, which is saturated, unsubstituted, monosubstituted or disubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -CN, =O, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6-alkylene-N(C 1-6 -alkyl)2, -SH, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl-C(=O)-NH2; in particular 3-14 membered cycloalkyl, which is saturated, unsubstituted, mono- or di-substituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -CN, =O, -C 1-6 -alkyl, -C 1-6 -alkylene-CF3, -CF3, -CF2H, -CFH2, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C1-6 -alkyl)2, -SH, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl-C(=O)-NH2; 3-14 membered heterocycloalkyl, wherein the 3-14 membered heterocycloalkyl is selected from azetidine, 1,4-oxazepane, pyrrolidine, piperidine, azepane, diazepane, tetrahydrofuran, tetrahydropyran, oxazoline, oxetane, morpholine, piperazine, hexahydrocyclopenta[c]pyrrole, octahydrocyclopenta[c]pyrrole, octahydropyrrolo[1,2-a]pyrazine, 8-azabicyclo[3.2.1]octane, 9-azabicyclo[3.3.1]nonane, quinuclidine, hexahydro-1H-pyrrolazine, 2-oxaspiro[3.3]heptane, 2-azaspiro[3.3]heptane, 7-azaspiro[3.5]nonane, 1,1-dioxothiocyclohexane, which are in each case unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -CN, =O, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -N(C 1-6-alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -SH, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl-C(=O)-NH2; unsubstituted -phenyl; specifically 3-14 membered heterocycloalkyl, wherein the 3-14 membered heterocycloalkyl is selected from azetidine, 1,4-oxazepane, pyrrolidine, piperidine, azepane, diazepane, tetrahydrofuran, tetrahydropyran, oxazoline, oxetane, morpholine, piperazine, hexahydrocyclopenta[c]pyrrole, octahydrocyclopenta[c]pyrrole, octahydropyrrolo[1,2-a]pyrazine, 8-azabicyclo[3,2 .1] octane, 9-azabicyclo[3.3.1]nonane, quinuclidine, hexahydro-1H-pyrrolazine, 2-oxaspiro[3.3]heptane, 2-azaspiro[3.3]heptane, 7-azaspiro[3.5]nonane, 1,1-dioxothiocyclohexane, which are in each case unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -CN, ═O, -C 1-6 -alkyl, -C 1-6 -alkylene-CF3, -CF3, -CF2H, -CFH2, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6-alkylene-C(=O)-NH2, -NH-C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -SH, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl-C(=O)-NH2; unsubstituted-phenyl; 5-14 membered heteroaryl, the 5-14 membered heteroaryl being in each case selected from the group consisting of pyridine, pyridazine, pyrazine, pyrazole, isoxazole, oxazole, imidazole, triazole, tetrazole and [1,2,4]triazolo[4,3-a]pyrimidine, which are in each case unsubstituted, monosubstituted or disubstituted independently of one another by substituents selected from the group consisting of -F, -Cl, -Br, -CN, =O, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6-alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -SH, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl-C(═O)-NH2; 5- to 14-membered heteroaryl, each of which is selected from the group consisting of pyridine, pyridazine, pyrazine, pyrazole, isoxazole, oxazole, imidazole, triazole, tetrazole and [1,2,4]triazolo[4,3-a]pyrimidine, each of which is unsubstituted, monosubstituted or disubstituted independently of one another by substituents selected from the group consisting of -F, -Cl, -Br, -CN, ═O, -C 1-6 -alkyl, -C 1-6 -alkylene-CF3, -CF3, -CF2H, -CFH2, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC1-6 -alkyl, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -SH, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl-C(=O)-NH2.

[0070] In some embodiments, A represents 3-14 membered cycloalkyl, which is saturated, unsubstituted, and R 2 Monosubstituted or polysubstituted; preferably 3-13 membered cycloalkyl, which is saturated, unsubstituted, R 2 Monosubstituted or polysubstituted; preferably 3-12 membered cycloalkyl, which is saturated, unsubstituted, R 2Monosubstituted or polysubstituted; preferably 3-11 membered cycloalkyl, which is saturated, unsubstituted, R 2 Monosubstituted or polysubstituted; preferably 3-10 membered cycloalkyl, which is saturated, unsubstituted, R 2 Mono- or polysubstituted; preferably represents a cycloalkyl residue selected from the group consisting of: or; 3-14 membered heterocycloalkyl, which is saturated, unsaturated, unsubstituted, or replaced by R 2 Monosubstituted or polysubstituted; preferably 3-13 membered heterocycloalkyl, which is saturated, unsaturated, unsubstituted, or R 2 Monosubstituted or polysubstituted; preferably 3-12 membered heterocycloalkyl, which is saturated, unsaturated, unsubstituted, or R 2 Monosubstituted or polysubstituted; preferably 3-11 membered heterocycloalkyl, which is saturated, unsaturated, unsubstituted, or replaced by R 2 Monosubstituted or polysubstituted; preferably 3-10 membered heterocycloalkyl, which is saturated, unsaturated, unsubstituted, R 2 Mono- or polysubstituted; preferably represents a heterocycloalkyl residue selected from the group consisting of: or 6-14 membered aryl, which is unsubstituted, replaced by R 2 Monosubstituted or polysubstituted; preferably 6-12 membered aryl, which is unsubstituted, R 2 Monosubstituted or polysubstituted; preferably 6-10 membered aryl, which is unsubstituted, R 2 Monosubstituted or polysubstituted; preferably 6-8 membered aryl, which is unsubstituted, R 2 Monosubstituted or polysubstituted; preferably phenyl, which is unsubstituted, replaced by R 2 mono- or poly-substituted; or 5-14 membered heteroaryl, which is unsubstituted, replaced by R 2 Monosubstituted or polysubstituted; preferably 5-12 membered heteroaryl, which is unsubstituted, replaced by R 2 Monosubstituted or polysubstituted; preferably 5-10 membered heteroaryl, which is unsubstituted, replaced by R 2 Monosubstituted or polysubstituted; preferably 5-9 membered heteroaryl, which is unsubstituted, replaced by R 2 Mono- or polysubstituted; preferably represents a residue selected from the group consisting of:

[0071] In some embodiments, R 2 Indicates -F, -Cl, -Br, -I, -CN, -NO, -NO2, =O, =S, -SF5, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C 1-6 -alkylene-CF2H, -C 1-6 -alkylene-CFH2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, O-(3-14 membered cycloalkyl), O-(6-14 membered aryl), O-(3-14 membered heterocycloalkyl), O-(5-14 membered heteroaryl), -C 1-6 -alkylene-OC 1-6 -alkyl, -OC 1-6 -alkylene-NH2, -OC(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-OC(=O)-C 1-6 -alkyl, -OC(=O)-OC 1-6 -alkyl, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-C 1-6 -alkylene-C(=O)-NH2, -N(C 1-6 -alkyl)-C 1-6-alkylene-C(=O)-NH-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -NH-C(=O)-(3-14 membered cycloalkyl), -NH-C(=O)-(6-14 membered aryl), -NH-C(=O)-(3-14 membered heterocycloalkyl), -NH-C(=O)-(5-14 membered heteroaryl), -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-(3-14 membered cycloalkyl), -N(C 1-6 -alkyl)-C(=O)-(6-14 membered aryl), -N(C 1-6 -alkyl)-C(=O)-(3-14 membered heterocycloalkyl), -N(C 1-6 -alkyl)-C(=O)-(5-14 membered heteroaryl), -NH-C(=O)-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-NH2, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C(=O)-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-OC1-6 -alkyl, -SH, -C 1-6 -alkylene-SH, -SCF3, -SCF2H, -SCFH2, -SC 1-6 -alkyl, -S-(3-14 membered cycloalkyl), -S-(6-14 membered aryl), -S-(3-14 membered heterocycloalkyl), -S-(5-14 membered heteroaryl), -S(=O)-C 1-6 -alkyl, -S(=O)-(3-14 membered cycloalkyl), -S(=O)-(6-14 membered aryl), -S(=O)-(3-14 membered heterocycloalkyl), -S(=O)-(5-14 membered heteroaryl), -S(=O)2-C 1-6 -alkyl, -S(=O)2-(3-14-membered cycloalkyl), -S(=O)2-(6-14-membered aryl), -S(=O)2-(3-14-membered heterocycloalkyl), -S(=O)2-(5-14-membered heteroaryl), -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14-membered cycloalkyl), -NH-S(=O)2-(6-14-membered aryl), -NH-S(=O)2-(3-14-membered heterocycloalkyl), -NH-S(=O)2-(5-14-membered heteroaryl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-(3-14 membered cycloalkyl), -N(C 1-6 -alkyl)-S(=O)2-(6-14 membered aryl), -N(C 1-6 -alkyl)-S(=O)2-(3-14 membered heterocycloalkyl), -N(C 1-6 -alkyl)-S(=O)2-(5-14 membered heteroaryl), -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-OH, -NH-S(=O)2-C 1-6 -alkylene-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-S(=O)2-C 1-6-alkylene-NH2, -NH-S(=O)2-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-S(=O)2-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-NH2, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-S(=O)2-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-C 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)-O(3-14 membered cycloalkyl), -C(=O)-O(6-14 membered aryl), -C(=O)-O(3-14 membered heterocycloalkyl), -C(=O)-O(5-14 membered heteroaryl), -C(=O)-NH2, -C(=O)-NH(C 1-6 -alkyl), -C(=O)-NH (3-14 membered cycloalkyl), -C(=O)-NH- (6-14 membered aryl), -C(=O)-NH (3-14 membered heterocycloalkyl), -C(=O)-NH (5-14 membered heteroaryl), -C(=O)-N(C 1-6 -alkyl)2, -C(=O)-N(C 1-6 -alkyl)(3-14 membered cycloalkyl); preferably R 2 Selected from: -F, -Cl, -Br, -I, -CN, -NO, -NO2, =O, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C 1-6 -alkylene-CF2H, -C 1-6 -alkylene-CFH2, -OH, -C1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, O-(3-14 membered cycloalkyl), O-(6-14 membered aryl), O-(3-14 membered heterocycloalkyl), O-(5-14 membered heteroaryl), -C 1-6 -alkylene-OC 1-6 -alkyl, -OC 1-6 -alkylene-NH2, -OC(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-OC(=O)-C 1-6 -alkyl, -OC(=O)-OC 1-6 -alkyl, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-C 1-6 -alkylene-C(=O)-NH2, -N(C 1-6 -alkyl)-C 1-6 -alkylene-C(=O)-NH-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-NH2, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C(=O)-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-OC 1-6 -alkyl, -SH, -C 1-6 -alkylene-SH, -SCF3, -SCF2H, -SCFH2, -SC 1-6 -alkyl, -S(=O)-C 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -S(=O)2-(3-14-membered cycloalkyl), -S(=O)2-(6-14-membered aryl), -S(=O)2-(3-14-membered heterocycloalkyl), -S(=O)2-(5-14-membered heteroaryl), -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14-membered cycloalkyl), -NH-S(=O)2-(6-14-membered aryl), -NH-S(=O)2-(3-14-membered heterocycloalkyl), -NH-S(=O)2-(5-14-membered heteroaryl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-OH, -NH-S(=O)2-C1-6 -alkylene-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkylene-NH2, -NH-S(=O)2-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-S(=O)2-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-NH2, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-S(=O)2-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-C 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)-O(3-14 membered cycloalkyl), -C(=O)-O(6-14 membered aryl), -C(=O)-O(3-14 membered heterocycloalkyl), -C(=O)-O(5-14 membered heteroaryl), -C(=O)-NH2, -C(=O)-NH(C 1-6 -alkyl), -C(=O)-NH (3-14 membered cycloalkyl), -C(=O)-NH- (6-14 membered aryl), -C(=O)-NH (3-14 membered heterocycloalkyl), -C(=O)-NH (5-14 membered heteroaryl), -C(=O)-N(C 1-6 -alkyl)2, -C(=O)-N(C 1-6 -alkyl)(3-14 membered cycloalkyl); preferably R 2 Selected from: -F, -Cl, -Br, -I, -CN, =O, -C1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C 1-6 -alkylene-CF2H, -C 1-6 -alkylene-CFH2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, O-(3-14 membered cycloalkyl), O-(6-14 membered aryl), -C 1-6 -alkylene-OC 1-6 -alkyl, -OC 1-6 -alkylene-NH2, -OC(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-OC(=O)-C 1-6 -alkyl, -OC(=O)-OC 1-6 -alkyl, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-C 1-6 -alkylene-C(=O)-NH2, -N(C 1-6 -alkyl)-C 1-6 -alkylene-C(=O)-NH-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C1-6 -alkylene-OH, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-NH2, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C(=O)-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-OC 1-6 -alkyl, -SH, -C 1-6 -alkylene-SH, -SC 1-6 -alkyl, -S(=O)-C 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -S(=O)2-(3-14 membered cycloalkyl), -S(=O)2-(6-14 membered aryl), -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-(6-14 membered aryl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-OH, -NH-S(=O)2-C1-6 -alkylene-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkylene-NH2, -NH-S(=O)2-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-S(=O)2-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-NH2, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-S(=O)2-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-C 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)-NH2, -C(=O)-NH(C 1-6 -alkyl), -C(=O)-N(C 1-6 -alkyl)2, -C(=O)-N(C 1-6 -alkyl)(3-14 membered cycloalkyl); preferably R 2 Selected from: -F, -Cl, -Br, -I, -CN, =O, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C 1-6 -alkylene-CF2H, -C 1-6 -alkylene-CFH2, -OH, -C 1-6-alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, O-(3-14 membered cycloalkyl), -C 1-6 -alkylene-OC 1-6 -alkyl, -OC 1-6 -alkylene-NH2, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-C 1-6 -alkylene-C(=O)-NH2, -N(C 1-6 -alkyl)-C 1-6 -alkylene-C(=O)-NH-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-NH2, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C(=O)-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-OC 1-6 -alkyl, -SH, -C 1-6 -alkylene-SH, -SC 1-6 -alkyl, -S(=O)-C 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-(6-14 membered aryl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-OH, -NH-S(=O)2-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkylene-NH2, -NH-S(=O)2-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-S(=O)2-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkylene-NH2, -NH-S(=O)2-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -C(=O)-C 1-6 -alkyl, -C 1-6-alkylene-C(=O)-C 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)-NH2, -C(=O)-NH(C 1-6 -alkyl); preferably R 2 Selected from: -F, -Cl, -Br, -I, -CN, =O, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C 1-6 -alkylene-CF2H, -C 1-6 -alkylene-CFH2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -C 1-6 -alkylene-OC 1-6 -alkyl, -OC 1-6 -alkylene-NH2, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6-alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-OC 1-6 -alkyl, -SH, -C 1-6 -alkylene-SH, -SC 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-(6-14 membered aryl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-OH, -NH-S(=O)2-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkylene-NH2, -NH-S(=O)2-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-S(=O)2-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-C 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)-NH2, -C(=O)-NH(C 1-6 -alkyl); preferably R 2 Selected from: -F, -Cl, -Br, -I, -CN, =O, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC1-6 -alkyl, -C 1-6 -alkylene-OC 1-6 -alkyl, -OC 1-6 -alkylene-NH2, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C(=O)-OC 1-6 -alkyl, -SH, -C 1-6 -alkylene-SH, -SC 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-OH, -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-C 1-6 -alkyl, -C1-6 -alkylene-C(=O)-C 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)-NH2; preferably R 2 Selected from: -F, -Cl, -Br, -CN, =O, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -SH, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14 membered cycloalkyl), -NH-S(=O)2-C1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl-C(=O)-NH2.

[0072] In some embodiments, R 5 and R 5 'Independently express -H; - C1-C6-alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C1-C6-heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 3-14 membered cycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted, specifically 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted.

[0073] Preferably, R 5 and R 5 ' independently of one another represent -H, -C1-C6-alkyl or -C1-C6-alkylene-N(C1-C6-alkyl)2.

[0074] In some embodiments, R 5 and R 5 At least one of ' is not -H.

[0075] In some embodiments, R 5 and R 5 'Both are -H.

[0076] In a preferred embodiment, T represents -O-, and U represents -(CR 5 R 5 ') n , and the resulting portion -O-(CR 5 R 5 ') n - represents a residue selected from the group consisting of:

[0077] In some embodiments, R5 Indicates -H, and R 5 ' represents a residue selected from the group consisting of: -H, -C 1-3 -alkyl, -CF3, -CF2H, -CFH2, -C 1-3 -alkylene-CF3, -C 1-3 -alkylene-CF2H, -C 1-3 -alkylene-CFH2 and -C 1-3 -alkylene-OH; preferably -H or C 1-3 -alkyl.

[0078] In some embodiments, R 6 、R 7 and R 8 Independently express -H; -F, -Cl, -Br, -I, -OH, -SH, -SF5, -CN, -NO2, -C(=O)OH, -NH2; -C 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -OC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -NHC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -N(C 1-6 -alkyl) 2, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C(=O)OC 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -OC(=O)C 1-6 - alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; -C 1-6 - heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted.

[0079] In some embodiments, R 6 、R 7 and R 8 Independently express -H; -F, -Cl, -Br, -I, -OH, -SH, -SF5, -CN, -NO2, -C(=O)OH, -NH2; -C 1-6-alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl, which are in each case saturated or unsaturated, unsubstituted, mono- or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -C 1-6 -alkyl, -C 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -NHC(=O)OC 1-6 -alkyl, -N(C 1-6 -alkyl)C(=O)OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)NH2, -C(=O)NH(C 1-6 -alkyl), -C(=O)N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -phenyl, -C 1-6 -alkylene-phenyl, saturated or unsaturated, unsubstituted 3-14 membered heterocycloalkyl; and unsubstituted 5-14 membered heteroaryl; -OC 1-6 -alkyl, which is saturated or unsaturated, unsubstituted, mono- or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -C 1-6 -alkyl, -C 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6-alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -NHC(=O)OC 1-6 -alkyl, -N(C 1-6 -alkyl)C(=O)OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)NH2, -C(=O)NH(C 1-6 -alkyl), -C(=O)N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -phenyl, -C 1-6 -alkylene-phenyl, saturated or unsaturated, unsubstituted 3-14 membered heterocycloalkyl; and unsubstituted 5-14 membered heteroaryl; -NHC 1-6 -alkyl, which is saturated or unsaturated, unsubstituted, mono- or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -C 1-6 -alkyl, -C 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -NHC(=O)OC 1-6 -alkyl, -N(C 1-6 -alkyl)C(=O)OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -C 1-6 -alkylene-NH2, -C 1-6-alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)NH2, -C(=O)NH(C 1-6 -alkyl), -C(=O)N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -phenyl, -C 1-6 -alkylene-phenyl, saturated or unsaturated, unsubstituted 3-14 membered heterocycloalkyl; and unsubstituted 5-14 membered heteroaryl; -N(C 1-6 -alkyl) 2, which is saturated or unsaturated, unsubstituted, mono- or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -C 1-6 -alkyl, -C 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -NHC(=O)OC 1-6 -alkyl, -N(C 1-6 -alkyl)C(=O)OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)OC 1-6 -alkyl, -C(=O)OC 1-6-alkylene-CF3, -C(=O)NH2, -C(=O)NH(C 1-6 -alkyl), -C(=O)N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -phenyl, -C 1-6 -alkylene-phenyl, saturated or unsaturated, unsubstituted 3-14 membered heterocycloalkyl; and unsubstituted 5-14 membered heteroaryl; -C(=O)OC 1-6 -alkyl, which is saturated or unsaturated, unsubstituted, mono- or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -C 1-6 -alkyl, -C 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -NHC(=O)OC 1-6 -alkyl, -N(C 1-6 -alkyl)C(=O)OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)NH2, -C(=O)NH(C 1-6 -alkyl), -C(=O)N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -phenyl, -C 1-6 -alkylene-phenyl, saturated or unsaturated, unsubstituted 3-14 membered heterocycloalkyl; and unsubstituted 5-14 membered heteroaryl; -OC(=O)C 1-6-alkyl, which is saturated or unsaturated, unsubstituted, mono- or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -C 1-6 -alkyl, -C 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -NHC(=O)OC 1-6 -alkyl, -N(C 1-6 -alkyl)C(=O)OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)NH2, -C(=O)NH(C 1-6 -alkyl), -C(=O)N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -phenyl, -C 1-6 -alkylene-phenyl, saturated or unsaturated, unsubstituted 3-14 membered heterocycloalkyl; and unsubstituted 5-14 membered heteroaryl -C 1-6 -heteroalkyl, which is saturated or unsaturated, unsubstituted, mono- or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -C 1-6 -alkyl, -C 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -NH2, -NHC 1-6-alkyl, -N(C 1-6 -alkyl)2, -NHC(=O)OC 1-6 -alkyl, -N(C 1-6 -alkyl)C(=O)OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)NH2, -C(=O)NH(C 1-6 -alkyl), -C(=O)N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -phenyl, -C 1-6 -alkylene-phenyl, saturated or unsaturated, unsubstituted 3-14 membered heterocycloalkyl; and unsubstituted 5-14 membered heteroaryl.

[0080] Preferably, R 6 、R 7 and R 8 Independently express -H, -F, -Cl, -Br, -I, -OH, -SH, -SF5, -CN, -NO2, -C(=O)OH, -NH2, -C 1-6 -alkyl, -CF3, -CHF2, -CH2F, -OC 1-6 -alkyl, -OCF3, -OCHF2, -OCH2F, -NHC1-6-alkyl, which is unsubstituted or substituted by one or more substituents independently selected from the group consisting of -OH, =O, -F, -Cl, -Br, -I, -SH, =S, -CN, -CF3, -CHF2, -CH2F, -OCF3, -OCHF2, -OCH2F, SF5, -NO2, -C(=O)OH, -NH2 and -C(=O)NH2; -N(C1-6-alkyl)2, which is unsubstituted or substituted by one or more substituents independently selected from the group consisting of: -OH, =O, -F, -Cl, -Br, -I, -SH, =S, -CN, -CF3, -CHF2, -CH2F, -OCF3, -OCHF2, -OCH2F, SF5, -NO2, -C(=O)OH, -NH2 and -C(=O)NH2; -C(=O)OC 1-6 -alkyl, which is unsubstituted or substituted by one or more substituents independently selected from the group consisting of: -OH, =O, -F, -Cl, -Br, -I, -SH, =S, -CN, -CF3, -CHF2, -CH2F, -OCF3, -OCHF2, -OCH2F, SF5, -NO2, -C(=O)OH, -NH2 and -C(=O)NH2; -OC(=O)C 1-6 -alkyl, which is unsubstituted or substituted by one or more substituents independently selected from the group consisting of: -OH, =O, -F, -Cl, -Br, -I, -SH, =S, -CN, -CF3, -CHF2, -CH2F, -OCF3, -OCHF2, -OCH2F, SF5, -NO2, -C(=O)OH, -NH2 and -C(=O)NH2; or -C 1-6 -heteroalkyl, which is unsubstituted or substituted by one or more substituents independently selected from the group consisting of: -OH, =O, -F, -Cl, -Br, -I, -SH, =S, -CN, -CF3, -CHF2, -CH2F, -OCF3, -OCHF2, -OCH2F, SF5, -NO2, -C(=O)OH, -NH2 and -C(=O)NH2.

[0081] In some embodiments, R 6 、R 7 and R 8 represent, independently of one another, a residue selected from the group consisting of: -H, -F, -Cl, -Br, -I, -CN, C 1-3 -alkyl, -CF3, -CF2H and -CFH2; preferably -H or -F.

[0082] In some embodiments, R 6 represents -H, -F, -Cl, -CN or -C1-C6-alkyl.

[0083] In some embodiments, R 6 represents a residue selected from the group consisting of: -H, -F, -Cl, -CN or -CH3; preferably -H, -F, -CN or -CH3.

[0084] In some embodiments, R 6 -H is not indicated.

[0085] In some embodiments, R 7 represents -H, -F, -Cl, -CN or -C1-C6-alkyl.

[0086] In some embodiments, R 7 -H is not indicated.

[0087] In some embodiments, R 7 represents a residue selected from the group consisting of: -H, -F, -Cl, -CN or CH3; preferably -H, -F, -Cl or -CH3.

[0088] In some embodiments, R 6 、R 7 and R 8 represent, independently of one another, a residue selected from the group consisting of -H, or

[0089] In some embodiments, R 8 represents -H, -F, -Cl, -CN or -C1-C6-alkyl.

[0090] In some embodiments, R 8 -H is not indicated.

[0091] In some embodiments, R 8 represents a residue selected from the group consisting of: -H, -F, -Cl, -CN or CH3; preferably -F.

[0092] In some embodiments (i)R 6 、R 7 and R 8 each represents -H; or (ii)R 6 、R 7 and R 8 The two in the table represent -H, and R 6 、R 7 and R 8 The other of represents -F, -Cl, -CN or -CH3; or (iii)R 6 、R 7 and R 8 One of them represents -H, and R 6 、R 7 and R 8The other of each independently represents -F, -Cl, -CN or -CH3.

[0093] In some embodiments, W represents 3-14 membered cycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-12 membered cycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-10 membered cycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-8 membered cycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-6 membered cycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the cycloalkyl is unsubstituted, monosubstituted or trisubstituted; preferably the cycloalkyl is unsubstituted, monosubstituted or disubstituted, specifically 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-12 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-10 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-8 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-6 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the cycloalkyl is unsubstituted, monosubstituted or trisubstituted; preferably the cycloalkyl is unsubstituted, monosubstituted or disubstituted; 6-14 membered aryl which is unsubstituted, monosubstituted or polysubstituted; preferably 6-12 membered aryl which is unsubstituted, monosubstituted or polysubstituted; preferably 6-10 membered aryl which is unsubstituted, monosubstituted or polysubstituted; wherein the aryl is unsubstituted, monosubstituted or trisubstituted; preferably the aryl is unsubstituted, monosubstituted or disubstituted; or 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-12 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-10 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-8 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-6 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the heterocycloalkyl is unsubstituted, monosubstituted or trisubstituted; preferably the heterocycloalkyl is unsubstituted, monosubstituted or disubstituted; 5-14 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; preferably 5-12 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; preferably 5-10 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; preferably 5-9 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; preferably 5-8 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; wherein the heteroaryl is unsubstituted, monosubstituted or trisubstituted; preferably the heteroaryl is unsubstituted, monosubstituted or disubstituted; -C1-C6-alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl; wherein the alkyl, alkenyl or alkynyl is unsubstituted, monosubstituted or trisubstituted; preferably the alkyl, alkenyl or alkynyl is unsubstituted, monosubstituted or disubstituted.

[0094] In some embodiments, W represents 3-14 membered saturated cycloalkyl, 5-14 membered cycloalkenyl, 8-14 membered cycloalkynyl, which are unsubstituted, monosubstituted or polysubstituted; preferably 3-12 membered saturated cycloalkyl, 5-12 membered cycloalkenyl, 8-12 membered cycloalkynyl, which are unsubstituted, monosubstituted or polysubstituted; preferably 3-10 membered saturated cycloalkyl, 5-10 membered cycloalkenyl, 8-10 membered cycloalkynyl, which are unsubstituted, monosubstituted or polysubstituted; preferably 3-8 membered saturated cycloalkyl, 5-8 membered cycloalkenyl, 8 membered cycloalkynyl, which are unsubstituted, monosubstituted or polysubstituted; preferably 3-6 membered saturated cycloalkyl, 5-6 membered cycloalkenyl, which are unsubstituted, monosubstituted or polysubstituted; wherein the cycloalkyl is unsubstituted, monosubstituted or trisubstituted; preferably the cycloalkyl is unsubstituted, monosubstituted or disubstituted; 6-14 membered aryl which is unsubstituted, monosubstituted or polysubstituted; preferably 6-12 membered aryl which is unsubstituted, monosubstituted or polysubstituted; preferably 6-10 membered aryl which is unsubstituted, monosubstituted or polysubstituted; wherein the aryl is unsubstituted, monosubstituted or trisubstituted; preferably the aryl is unsubstituted, monosubstituted or disubstituted; or 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-12 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-10 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-8 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-6 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the heterocycloalkyl is unsubstituted, monosubstituted or trisubstituted; preferably the heterocycloalkyl is unsubstituted, monosubstituted or disubstituted; 5-14 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; preferably 5-12 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; preferably 5-10 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; preferably 5-9 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; preferably 5-8 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; wherein the heteroaryl is unsubstituted, monosubstituted or trisubstituted; preferably the heteroaryl is unsubstituted, monosubstituted or disubstituted; -C1-C6-alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl; wherein the alkyl, alkenyl or alkynyl is unsubstituted, monosubstituted or trisubstituted; preferably the alkyl, alkenyl or alkynyl is unsubstituted, monosubstituted or disubstituted. In some embodiments, W represents 3-14 membered cycloalkyl, which is saturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-12 membered cycloalkyl, which is saturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-10 membered cycloalkyl, which is saturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-8 membered cycloalkyl, which is saturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-6 membered cycloalkyl, which is saturated, unsubstituted, monosubstituted or polysubstituted; wherein the cycloalkyl is unsubstituted, monosubstituted or trisubstituted; preferably the cycloalkyl is unsubstituted, monosubstituted or disubstituted; 6-14 membered aryl which is unsubstituted, monosubstituted or polysubstituted; preferably 6-12 membered aryl which is unsubstituted, monosubstituted or polysubstituted; preferably 6-10 membered aryl which is unsubstituted, monosubstituted or polysubstituted; wherein the aryl is unsubstituted, monosubstituted or trisubstituted; preferably the aryl is unsubstituted, monosubstituted or disubstituted; or 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-12 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-10 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-8 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-6 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the heterocycloalkyl is unsubstituted, monosubstituted or trisubstituted; preferably the heterocycloalkyl is unsubstituted, monosubstituted or disubstituted; 5-14 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; preferably 5-12 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; preferably 5-10 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; preferably 5-9 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; preferably 5-8 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; wherein the heteroaryl is unsubstituted, monosubstituted or trisubstituted; preferably the heteroaryl is unsubstituted, monosubstituted or disubstituted; -C1-C6-alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl; which are in each case unsubstituted, monosubstituted or disubstituted wherein the substituents are independently selected from the group consisting of: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6-alkyl)2, 3-14 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 14 membered heteroaryl.

[0095] In some embodiments, W represents a 3-10 membered cycloalkyl group which is unsubstituted, monosubstituted or polysubstituted, a 6-12 membered aryl group which is unsubstituted, monosubstituted or polysubstituted, a 3-10 membered heterocycloalkyl group which is saturated or unsaturated, monosubstituted or polysubstituted, a 5-12 membered heteroaryl group which is monosubstituted or polysubstituted, a -C1-C6-alkyl group, a halo-C 1-6 alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl; preferably W represents a 3-10 membered cycloalkyl group which is unsubstituted, monosubstituted or disubstituted, a 6-12 membered aryl group which is unsubstituted, monosubstituted or disubstituted, a 3-10 membered heterocycloalkyl group which is saturated or unsaturated, monosubstituted or disubstituted, a 5-12 membered heteroaryl group which is monosubstituted or disubstituted or -C1-C6-alkyl, a halogenated C 1-6 alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl, which are in each case unsubstituted, monosubstituted or disubstituted; preferably W represents 3-10 membered cycloalkyl, which is unsubstituted, monosubstituted or disubstituted, 6-12 membered aryl, which is unsubstituted, monosubstituted or disubstituted, 3-10 membered heterocycloalkyl, which is saturated or unsaturated, monosubstituted or disubstituted, 5-12 membered heteroaryl, which is monosubstituted or disubstituted, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl and tert-butyl; pentyl, hexyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -CCl3, -C 1-6 -alkylene-CCl3 or -C 1-6 -alkylene-CF3.

[0096] In some embodiments, W represents 3-14 membered cycloalkyl, which is saturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-13 membered cycloalkyl, which is saturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-12 membered cycloalkyl, which is saturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-11 membered cycloalkyl, which is saturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-10 membered cycloalkyl, which is saturated, unsubstituted, monosubstituted or polysubstituted; preferably represents a cycloalkyl residue selected from the group consisting of: 6-14 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; preferably 6-12 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; preferably 6-10 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; preferably 6-8 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; preferably represents a phenyl residue selected from the group consisting of: or 3-14 membered heterocycloalkyl, which is saturated, unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-13 membered heterocycloalkyl, which is saturated, unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-12 membered heterocycloalkyl, which is saturated, unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-11 membered heterocycloalkyl, which is saturated, unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably 3-10 membered heterocycloalkyl, which is saturated, unsaturated, unsubstituted, monosubstituted or polysubstituted; preferably represents a heterocycloalkyl residue selected from the group consisting of: ; More preferably selected from the group consisting of: or 5-14 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; preferably 5-12 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; preferably 5-10 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; preferably 5-9 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; more preferably represents a residue selected from the group consisting of: More preferably represents a residue selected from the group consisting of: or -C1-C6-alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl; which are in each case unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6-alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, 3-14 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 14 membered heteroaryl.

[0097] In some embodiments, the 5-14 membered heteroaryl group within the definition of W is selected from benzimidazole, benzisoxazole, benzoxazole, benzodioxole, benzofuran, benzothiadiazole, benzothiazole, benzothiophene, carbazole, cinnoline, dibenzofuran, furan, furazan, imidazole, imidazopyridine, indazole, indole, indolizine, isobenzofuran, isoindole, isoquinoline, isothiazole, isoxazole, naphthyridine, oxadiazole, oxazole, oxindole, phthalazine, purine, pyrazine, pyrazole, pyridazine, pyridine, pyrimidine, pyrrole, quinazoline, quinoline, quinoxaline, pyrimidine, benzoimidazole, benzoisoxazole, benzodioxole, benzofuran, benzothiazole, benzothiophene, cinnoline, dibenzofuran, furan, thiophene, furazan, imidazole, imidazopyridine, indole, isobenzofuran, isoindole, isoquinoline, isoxazole, oxadiazole, oxazole, oxindole, pyrazine, pyrazole, pyridazine, pyridine , pyrimidine, pyrrole, quinoline, tetrazole, thiadiazole, thiazole, thiophene, triazine, triazole and [1,2,4]triazolo[4,3-a]pyrimidine; which are in each case unsubstituted, monosubstituted or polysubstituted; preferably defined in the group consisting of furan, thiophene, imidazole, pyrazole, oxazole, isoxazole, thiazole, triazole, pyridine, isoquinoline, benzothiazole, pyridazine, pyrimidine, imidazopyridine; which are in each case unsubstituted, monosubstituted or polysubstituted; preferably defined in the group consisting of furan-2-yl, furan-3-yl, thiophene- 2-yl, thien-3-yl, pyrazol-5-yl, oxazol-5-yl, isoxazol-4-yl, thiazol-2-yl, thiazol-5-yl, 1,2,4-triazol-3-yl, 1,2,3-triazol-4-yl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, isoquinolin-1-yl, isoquinolin-5-yl, benzo[d]thiazol-2-yl, pyridazin-3-yl, pyrimidin-5-yl and imidazo[1,2-a]pyridin-6-yl, which are in each case unsubstituted, monosubstituted or polysubstituted.

[0098] In some embodiments, the 3-14 membered heterocycloalkyl group within the definition of W is selected from azepane, 1,4-oxazepane, azetidine, aziridine, azocane, diazepane, dioxane, dioxolane, dithiane, dithiolane, imidazolidine, isothiazolidine, isoxazolidine, morpholine, oxazolidine, oxetane, oxetane, oxirane, piperazine, piperidine, pyrazolidine, pyrrolidine, quinuclidine, tetrahydrofuran, tetrahydropyran, tetrahydrothiopyran, thiazolidine, thietane, thiirane, thiolane, thiomorpholine, indoline, dihydrobenzofuran, dihydrobenzothiophene, 1,1-dioxothiocyclohexane, 2-azaspiro[3.3]heptane, 2 -oxaspiro[3.3]heptane, 7-azaspiro[3.5]nonane, 8-azabicyclo[3.2.1]octane, 9-azabicyclo[3.3.1]nonane, hexahydro-1H-pyrrolazine, hexahydrocyclopenta[c]pyrrole, octahydrocyclopenta[c]pyrrole and octahydropyrrolo[1,2-a]pyrazine; which are in each case unsubstituted, monosubstituted or polysubstituted; preferably defined from the group consisting of azepane, azetidine, aziridine, diazepane, dioxane, dioxolane, dithiane, dithiolane, imidazolidine, isoxazolidine, morpholine, oxazolidine, oxetane, oxetane, oxirane, piperazine, piperidine, pyrazolidine, pyrrolidine, quinuclidine, tetracycline substituted benzophenone, 2-azaspiro[3.3]heptane, 2-oxaspiro[3.3]heptane, 7-azaspiro[3.5]nonane, hexahydro-1H-pyrrolizine, hexahydrocyclopenta[c]pyrrole, octahydrocyclopenta[c]pyrrole and octahydropyrrolo[1,2-a]pyrazine; which are in each case unsubstituted, monosubstituted or polysubstituted; preferably defined as azepane, azetidine, aziridine, diazepane, dioxane, dioxolane, dithiolane, imidazolidine, isoxazolidine, morpholine, oxazolidine, oxetane, oxetane, oxirane, piperazine, piperazine, 1-yl, tetrahydrofuran-2-yl, tetrahydropyran-1-yl, tetrahydropyran-2-yl, tetrahydropyran-3-yl, tetrahydropyran-4-yl, thiazolidine, thiolane and indoline, which are each unsubstituted, monosubstituted or polysubstituted.

[0099] In some embodiments, the 5-14 membered heteroaryl group within the definition of W represents a residue according to formula (E) in Y E1 Indicates -N=, -NR E2 -, S, O, or -CR E3 =;Y E2 Indicates -N=, -NR E3 -, S, O, or -CR E4 =, and Y E3 Indicates -N=, -NR E4 -, S, O, or -CR E5 =; condition is Y E1 、Y E2 and Y E3 At least one of them is not -CR E3 =, -CR E4 = and -CR E5 = In another preferred embodiment, W represents a residue according to formula (E) wherein YE1 represents -N=, -NRE2-, S or -CRE3=; YE2 represents -N=, -NRE3-, S or -CRE4=; and YE3 represents -N=, -NRE4-, S or -CRE5=; provided that at least one of YE1, YE2 and YE3 is not -CRE3=, -CRE4= and -CRE5=, respectively. R E1 、R E2 、R E3 and R E4 independently of one another represent -H, -CH3, -CH2-cyclopropyl, -CH2CF3, -CH2CHF2 or -CF3; more specifically R E1 、R E2 、R E3 and R E4 independently represent -H, -CH3 or -CF3; preferably with the proviso that R E1 、R E2 、R E3 and R E4 Only one of represents a residue other than -H.

[0100] In some embodiments, the 5-14 membered heteroaryl group within the definition of W represents a residue according to the general formula (F') in Y F1 Indicates -N= or -CR F4 =; and Y F2 Indicates -N= or -CR F5 =; and Y F3 Indicates -N= or -CRF3 =; condition is Y F1 and Y F2 At least one of them is not -CR F4 = and -CR F5 =; R F1 、R F2 、R F3 、R F4 and R F5 independently of one another represent -H, -CH3, -CF3, -OH, -OCH3, -OCH2CH3, -Cl or -azetidinyl; preferably with the proviso that R F1 、R F2 、R F3 、R F4 and R F5 Only one of represents a residue other than -H.

[0101] In some embodiments, the 5-14 membered heteroaryl group within the definition of W represents a residue according to formula (F) in Y F1 Indicates -N= or -CR F4 =; and Y F2 Indicates -N= or -CR F5 =; condition is Y F1 and Y F2 At least one of them is not -CR F4 = and -CR F5 =; R F1 、R F2 、R F3 、R F4 and R F5 independently of one another represent -H, -CH3, -CF3, -OH, -OCH3, -OCH2CH3, -Cl or -azetidinyl; preferably with the proviso that R F1 、R F2 、R F3 、R F4 and R F5 Only one of represents a residue other than -H.

[0102] In some embodiments, the 5-14 membered heteroaryl group within the definition of W represents a residue according to formula (G) or (H) where R G1 and R H1is selected from the group consisting of: -H, -CH3, -CF3, -OH, -OCH3, -OCH2CH3, -Cl, azetidinyl, -cyclopropyl, -O-cyclopropyl, and -CHF2; or wherein R G1 and R H1 Selected from the group consisting of: -H, -CH3, -CF3, -OH, -OCH3, -OCH2CH3, -Cl and azetidinyl.

[0103] In some embodiments, the 5-14 membered heteroaryl group within the definition of W represents a residue according to formula (G') or (H') where R G1 and R H1 is selected from the group consisting of: -H, -CH3, -CF3, -OH, -OCH3, -OCH2CH3, -Cl, azetidinyl, -cyclopropyl, -O-cyclopropyl, and -CHF2; or wherein R G1 and R H1 Selected from the group consisting of: -H, -CH3, -CF3, -OH, -OCH3, -OCH2CH3, -Cl and azetidinyl;

[0104] In some embodiments, 5-14 membered heteroaryl within the definition of W represents a residue according to formula (E), (F), (F'), (G), (H), (G'), or (H') as defined above.

[0105] In some embodiments, the term "mono- or poly-substituted" independently in each instance means substituted with one or more substituents independently selected from the group consisting of: -F, -Cl, -Br, -I, -CN, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C 1-6 -alkylene-CF2H, -C 1-6 -alkylene-CFH2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-C 1-6 -alkyl, -C(=O)OH, -C 1-6 -alkylene-C(=O)-OH, -C(=O)-OC 1-6-alkyl, -C 1-6 -alkylene-C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)-NH2, -C 1-6 -alkylene-C(=O)-NH2, -C(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -C(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -C(=O)-NH(OH), -C 1-6 -alkylene-C(=O)-NH(OH), -OH, -C 1-6 -alkylene-OH, =O, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -C 1-6 -alkylene-OC 1-6 -alkyl, -OC 1-6 -alkylene-OC 1-6 -alkyl, -OC 1-6 -alkylene-NH2, -OC 1-6 -alkylene-NH-C 1-6 -alkyl, -OC 1-6 -alkylene-N(C 1-6 -alkyl)2, -OC(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-OC(=O)-C 1-6 -alkyl, -OC(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-OC(=O)-OC 1-6 -alkyl, -OC(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-OC(=O)-NH(C 1-6 -alkyl), -OC(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-OC(=O)-N(C 1-6 -alkyl)2, -OS(=O)2-NH2, -C 1-6 -alkylene-OS(=O)2-NH2, -OS(=O)2-NH(C 1-6 -alkyl), -C1-6 -alkylene-OS(=O)2-NH(C 1-6 -alkyl), -OS(=O)2-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-OS(=O)2-N(C 1-6 -alkyl)2, -NH2, -NO, -NO2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-NH-C(=O)-C 1-6 -alkyl, -NH-C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-NH-C(=O)-OC 1-6 -alkyl, -NH-C(=O)-NH2, -C 1-6 -alkylene-NH-C(=O)-NH2, -NH-C(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-NH-C(=O)-NH(C 1-6 -alkyl), -NH-C(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C(=O)-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-NH2, -N(C 1-6-alkyl)-C(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)-C(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-N(C 1-6 -alkyl)2, -NH-S(=O)2OH, -C 1-6 -alkylene-NH-S(=O)2OH, -NH-S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-OC 1-6 -alkyl, -C 1-6 -alkylene-NH-S(=O)2-OC 1-6 -alkyl, -NH-S(=O)2-NH2, -C 1-6 -alkylene-NH-S(=O)2-NH2, -NH-S(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-NH-S(=O)2-NH(C 1-6 -alkyl), -NH-S(=O)2N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-S(=O)2N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-S(=O)2-OH, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-OH, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-NH2, -C 1-6-alkylene-N(C 1-6 -alkyl)-S(=O)2-NH2, -N(C 1-6 -alkyl)-S(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)-S(=O)2-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-N(C 1-6 -alkyl)2, -SH, =S, -SF5, -SCF3, -SCF2H, -SCFH2, -SC 1-6 -alkyl, -C 1-6 -alkylene-SC 1-6 -alkyl, -S(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-S(=O)-C 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-S(=O)2-C 1-6 -alkyl, -S(=O)2-OH, -C 1-6 -alkylene-S(=O)2-OH, -S(=O)2-OC 1-6 -alkyl, -C 1-6 -alkylene-S(=O)2-OC 1-6 -alkyl, -S(=O)2-NH2, -C 1-6 -alkylene-S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-S(=O)2-N(C 1-6 -alkyl) 2, 3-14 membered cycloalkyl, -C 1-6 -alkylene-(3-14 membered cycloalkyl), 3 to 14 membered heterocycloalkyl, -C 1-6 -alkylene-(3 to 14 membered heterocycloalkyl), -phenyl, -C 1-6 -alkylene-phenyl, 5- to 14-membered heteroaryl, -C 1-6-alkylene-(5- to 14-membered heteroaryl), -O-(3- to 14-membered cycloalkyl), -O-(3- to 14-membered heterocycloalkyl), -O-phenyl, -O-(5- to 14-membered heteroaryl), -C(═O)-(3- to 14-membered cycloalkyl), -C(═O)-(3- to 14-membered heterocycloalkyl), -C(═O)-phenyl, -C(═O)-(5- to 14-membered heteroaryl), -S(═O)2-(3- to 14-membered cycloalkyl), -S(═O)2-(3- to 14-membered heterocycloalkyl), -S(═O)2-phenyl or -S(═O)2-(5- to 14-membered heteroaryl); preferably the terms independently in each case mean substituted by one or more substituents independently of one another selected from the group consisting of: -F, -Cl, -Br, -I, -CN, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C 1-6 -alkylene-CF2H, -C 1-6 -alkylene-CFH2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C 1-6 -alkylene-CF3, -C(=O)OH, -C 1-6 -alkylene-C(=O)-OH, -C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)-NH2, -C 1-6 -alkylene-C(=O)-NH2, -C(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -C(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -OH, -C 1-6 -alkylene-OH, =O, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -C 1-6 -alkylene-OC 1-6 -alkyl, -OC(=O)-C 1-6 -alkyl, -C 1-6-alkylene-OC(=O)-C 1-6 -alkyl, -OC(=O)-NH(C 1-6 -alkyl), -NH2, -NO, -NO2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-NH-C(=O)-C 1-6 -alkyl, -NH-C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-NH-C(=O)-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-NH2, -NH-S(=O)2OH, -C 1-6 -alkylene-NH-S(=O)2OH, -NH-S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-OC 1-6 -alkyl, -C 1-6 -alkylene-NH-S(=O)2-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-OH, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-OH, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-N(C1-6 -alkyl)-S(=O)2-C 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-NH2, -N(C 1-6 -alkyl)-S(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)-S(=O)2-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-N(C 1-6 -alkyl)2, -SH, =S, -SF5, -SCF3, -SCF2H, -SCFH2, -SC 1-6 -alkyl, -C 1-6 -alkylene-SC 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-S(=O)2-C 1-6 -alkyl, -S(=O)2-OH, -C 1-6 -alkylene-S(=O)2-OH, -S(=O)2-OC 1-6 -alkyl, -C 1-6 -alkylene-S(=O)2-OC 1-6 -alkyl, -S(=O)2-NH2, -C 1-6 -alkylene-S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-S(=O)2-N(C 1-6 -alkyl) 2, 3-14 membered cycloalkyl, -C 1-6-alkylene-(3-14 membered cycloalkyl), 3 to 14 membered heterocycloalkyl, -C 1-6 -alkylene-(3 to 14 membered heterocycloalkyl), -phenyl, -C 1-6 -alkylene-phenyl, 5- to 14-membered heteroaryl, -C 1-6 -alkylene-(5- to 14-membered heteroaryl), -O-(3- to 14-membered cycloalkyl), -O-(3- to 14-membered heterocycloalkyl), -O-phenyl, -O-(5- to 14-membered heteroaryl), -S(=O)2-(3- to 14-membered cycloalkyl), -S(=O)2-(3- to 14-membered heterocycloalkyl), -S(=O)2-phenyl or -S(=O)2-(5- to 14-membered heteroaryl); preferably, the terms independently in each case mean substituted by one or more substituents independently of one another selected from the group consisting of: -F, -Cl, -Br, -I, -CN, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C 1-6 -alkylene-CF2H, -C 1-6 -alkylene-CFH2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C 1-6 -alkylene-CF3, -C(=O)OH, -C 1-6 -alkylene-C(=O)-OH, -C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)-NH2, -C 1-6 -alkylene-C(=O)-NH2, -C(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -C(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -OH, -C 1-6 -alkylene-OH, =O, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -C 1-6 -alkylene-OC 1-6-alkyl, -OC(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-OC(=O)-C 1-6 -alkyl, -OC(=O)-NH(C 1-6 -alkyl), -NH2, -NO, -NO2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-OH, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-NH2, -N(C 1-6 -alkyl)-S(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)-S(=O)2-N(C 1-6-alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-N(C 1-6 -alkyl)2, -SH, -SC 1-6 -alkyl, -C 1-6 -alkylene-SC 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-S(=O)2-C 1-6 -alkyl, -S(=O)2-OH, -C 1-6 -alkylene-S(=O)2-OH, -S(=O)2-OC 1-6 -alkyl, -C 1-6 -alkylene-S(=O)2-OC 1-6 -alkyl, -S(=O)2-NH2, -C 1-6 -alkylene-S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-S(=O)2-N(C 1-6 -alkyl) 2, 3-14 membered cycloalkyl, -C 1-6 -alkylene-(3-14 membered cycloalkyl), 3 to 14 membered heterocycloalkyl, -C 1-6 -alkylene-(3 to 14 membered heterocycloalkyl), -phenyl, -C 1-6 -alkylene-phenyl, 5- to 14-membered heteroaryl, -C 1-6 -alkylene-(5- to 14-membered heteroaryl), -O-(3- to 14-membered cycloalkyl), -O-(3- to 14-membered heterocycloalkyl), -O-phenyl, -S(=O)2-(3- to 14-membered cycloalkyl), -S(=O)2-(3- to 14-membered heterocycloalkyl), -S(=O)2-phenyl or -S(=O)2-(5- to 14-membered heteroaryl); preferably, the terms independently in each case mean substituted by one or more substituents independently of one another selected from the group consisting of: -F, -Cl, -Br, -I, -CN, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C 1-6 -alkylene-CF2H, -C 1-6 -alkylene-CFH2, -C 1-6 -alkylene-NH-C 1-6-alkylene-CF3, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C 1-6 -alkylene-CF3, -C(=O)OH, -C 1-6 -alkylene-C(=O)-OH, -C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)-NH2, -C 1-6 -alkylene-C(=O)-NH2, -C(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -C(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -OH, -C 1-6 -alkylene-OH, =O, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -C 1-6 -alkylene-OC 1-6 -alkyl, -OC(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-OC(=O)-C 1-6 -alkyl, -OC(=O)-NH(C 1-6 -alkyl), -NH2, -NO2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -N(C1-6 -alkyl)-S(=O)2-C 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -SH, -SC 1-6 -alkyl, -C 1-6 -alkylene-SC 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-S(=O)2-C 1-6 -alkyl, -S(=O)2-OH, -C 1-6 -alkylene-S(=O)2-OH, -S(=O)2-OC 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl) 2, 3-12 membered cycloalkyl, -C 1-6 -alkylene-(3-12 membered cycloalkyl), 3 to 12 membered heterocycloalkyl, -C 1-6 -alkylene-(3 to 12 membered heterocycloalkyl), -phenyl, -C 1-6 -alkylene-phenyl, 5- to 12-membered heteroaryl, -C 1-6 -alkylene-(5- to 12-membered heteroaryl); preferably the term independently in each case means substituted by one or more substituents independently of one another selected from the group consisting of: -F, -Cl, -Br, -I, -CN, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C 1-6 -alkylene-CF2H, -C 1-6 -alkylene-CFH2, -C 1-6 -alkylene-NH-C 1-6 -alkylene-CF3, -C(=O)OH, -C 1-6 -alkylene-C(=O)-OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)-NH2, -C(=O)-NH(C 1-6 -alkyl), C(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -OH, -C 1-6-alkylene-OH, =O, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -OC(=O)-C 1-6 -alkyl, -OC(=O)-NH(C 1-6 -alkyl), -NH2, -NO2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -SH, -SC 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -S(=O)2-OH, -S(=O)2-OC 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl) 2, 3-12 membered cycloalkyl, -C 1-6 -alkylene-(3-12 membered cycloalkyl), 3 to 12 membered heterocycloalkyl, -C 1-6 -alkylene-(3 to 12 membered heterocycloalkyl), -phenyl, -C 1-6 -alkylene-phenyl, 5- to 12-membered heteroaryl, -C 1-6 -alkylene-(5- to 12-membered heteroaryl); preferably the term independently in each case means substituted by one or more substituents independently of one another selected from the group consisting of: -F, -Cl, -Br, -I, -CN, -C 1-5 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-5 -alkylene-CF3, -C 1-5 -alkylene-NH-C 1-5 -alkylene-CF3, -C(=O)OH, -C 1-5 -alkylene-C(=O)-OH, -C(=O)-OC 1-5 -alkyl, -C(=O)-NH2, -C(=O)-NH(C 1-5 -alkyl), C(=O)-N(C 1-5-alkyl)2, -OH, -C 1-5 -alkylene-OH, =O, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-5 -alkyl, -OC(=O)-C 1-5 -alkyl, -OC(=O)-NH(C 1-6 -alkyl), -NH2, -NO2, -C 1-5 -alkylene-NH2, -NH(C 1-5 -alkyl), -C 1-5 -alkylene-NH(C 1-5 -alkyl), -N(C 1-5 -alkyl)2, -C 1-5 -alkylene-N(C 1-5 -alkyl)2, -N(C 1-5 -alkyl)-S(=O)2-C 1-5 -alkyl, -N(C 1-5 -alkyl)-S(=O)2-OC 1-5 -alkyl, -SH, -SC 1-5 Alkyl, -S(=O)2-C 1-5 Alkyl, -S(=O)2-OH, -S(=O)2-OC 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl) 2, 3-10 membered cycloalkyl, -C 1-5 -alkylene-(3-10 membered cycloalkyl), 3 to 10 membered heterocycloalkyl, -C 1-5 -alkylene-(3 to 10 membered heterocycloalkyl), -phenyl, -C 1-5 -alkylene-phenyl, 5- to 10-membered heteroaryl, -C 1-5 -alkylene-(5- to 10-membered heteroaryl).

[0106] In some embodiments, the 3-14 membered cycloalkyl group within the definition of W is unsubstituted, monosubstituted, or disubstituted with a substituent selected from the group consisting of: -F, -Cl, -Br, -I, -CN, C 1-3 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-3 -alkylene-CF3, -C 1-3 -alkylene-CF2H, -C 1-3 -alkylene-CFH 2、 -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-3-alkyl, -C 1-3 -alkylene-OC 1-3 -alkyl and -C 1-3 -Alkylene-OH; preferably -F, -Cl, -Br, -I, -CN, -CH3, -CF3, -CF2H, -CFH2, -OCF3 and -OCH3.

[0107] In some embodiments, the 6-14 membered aryl group within the definition of W is unsubstituted, monosubstituted, or disubstituted with a substituent selected from the group consisting of: -F, -Cl, -Br, -I, -CN, C 1-3 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-3 -alkylene-CF3, -C 1-3 -alkylene-CF2H, -C 1-3 -alkylene-CFH 2、 -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-3 -alkyl, -C 1-3 -alkylene-OC 1-3 -alkyl and -C 1-3 -Alkylene-OH; preferably -F, -Cl, -Br, -I, -CN, -CH3, -CF3, -CF2H, -CFH2, -OCF3 and -OCH3.

[0108] In some embodiments, the 5-14 membered heteroaryl group within the definition of W is unsubstituted, monosubstituted, or disubstituted with a substituent selected from the group consisting of: -F, -Cl, -Br, -I, -CN, C 1-3 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-3 -alkylene-CF3, -C 1-3 -alkylene-CF2H, -C 1-3 -alkylene-CFH 2、 -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-3 -alkyl, -C 1-3 -alkylene-OC 1-3 -alkyl and -C 1-3 -Alkylene-OH; preferably -F, -Cl, -Br, -I, -CN, -CH3, -CF3, -CF2H, -CFH2, -OCF3 and -OCH3.

[0109] In some embodiments, the -C1-C6-alkyl group within the definition of W is unsubstituted, monosubstituted, or disubstituted with a substituent selected from the group consisting of: -F, -Cl, -Br, -I, -CN, C 1-3 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-3 -alkyl and -OH; preferably -F, -Cl, -Br, -I, -CN, -CH3, -CF3, -CF2H, -CFH2, -OCF3 and -OCH3.

[0110] In some embodiments, the 3-14 membered heterocycloalkyl group within the definition of W is unsubstituted, monosubstituted, or disubstituted with a substituent selected from the group consisting of: -F, -Cl, -Br, -I, -CN, C 1-3 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-3 -alkylene-CF3, -C 1-3 -alkylene-CF2H, -C 1-3 -alkylene-CFH 2、 -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-3 -alkyl, -C 1-3 -alkylene-OC 1-3 -alkyl and -C 1-3 -Alkylene-OH; preferably -F, -Cl, -Br, -I, -CN, -CH3, -CF3, -CF2H, -CFH2, -OCF3 and -OCH3.

[0111] In some embodiments of the present invention, the compound is selected from the group consisting of Cpd 001-[1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropyl]methanol; Cpd 002-(2-{2-methyl-5-[(4-methyl-1,3-thiazol-5-yl)methoxy]-1-benzofuran-3-yl}-1,3-oxazol-5-yl)methanol; Cpd 003-2-hydroxy-N-[1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropyl]acetamide; Cpd 004-(1-{2-methyl-5-[(4-methyl-1,3-thiazol-5-yl)methoxy]-1-benzofuran-3-yl}cyclopropyl)methanol; Cpd 005-N-[1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropyl]cyclopropanesulfonamide; Cpd 006-N-[1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropyl]methanesulfonamide; Cpd 007-(2-{2-methyl-5-[(4-methyl-1,3-thiazol-5-yl)methoxy]-1-benzofuran-3-yl}-1H-imidazol-4-yl)methanol; Cpd 008-3-methoxy-N-[1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropyl]propionamide; Cpd 009-2-hydroxy-2-methyl-N-[1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropyl]propionamide; Cpd 010-2-methoxy-N-[1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropyl]acetamide; Cpd 011-1-{2-methyl-5-[(4-methyl-1,3-thiazol-5-yl)methoxy]-1-benzofuran-3-yl}cyclopropane-1-carbonitrile; Cpd 012-2-{[1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropyl]amino}acetamide; Cpd 013-1-cyclopropyl-N-[1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropyl]methanesulfonamide; Cpd 014-1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropane-1-amine; Cpd 015-2-{[1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropyl]amino}propanamide; Cpd 016-1-[1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropyl]methanamine; Cpd 017-2-hydroxy-N-(1-{2-methyl-5-[(4-methyl-1,3-thiazol-5-yl)methoxy]-1-benzofuran-3-yl}cyclopropyl)acetamide; Cpd 018-3-[({3-[4,4-bis(hydroxymethyl)-4,5-dihydro-1,3-oxazol-2-yl]-2-methyl-1-benzofuran-5-yl}oxy)methyl]pyridin-2-ol; Cpd 019-1-[5-(Benzyloxy)-2-methyl-1-benzofuran-3-yl]cyclopropane-1-carbonitrile; Cpd 020-N-(2-hydroxyethyl)-1-{2-methyl-5-[(4-methyl-1,3-thiazol-5-yl)methoxy]-1-benzofuran-3-yl}cyclopropane-1-carboxamide; Cpd 021-{1-[5-(benzyloxy)-2-methyl-1-benzofuran-3-yl]cyclopropyl}methanol; Cpd 022-1-{2-methyl-5-[(4-methyl-1,3-thiazol-5-yl)methoxy]-1-benzofuran-3-yl}cyclopropane-1-carboxamide; Cpd 023-5-{5-[(2-chloro-6-fluorophenyl)methoxy]-2-methyl-1-benzofuran-3-yl}-2H-1,2,3,4-tetrazolyl; Cpd 024-1-{2-methyl-5-[(pyridin-2-yl)methoxy]-1-benzofuran-3-yl}cyclopropane-1-amine; Cpd 025-1-[5-(cyclopropylmethoxy)-2-methyl-1-benzofuran-3-yl]cyclopropane-1-amine; Cpd 026-1-{2-methyl-5-[(2-methyl-1,3-thiazol-5-yl)methoxy]-1-benzofuran-3-yl}cyclopropane-1-amine; Cpd 027-1-{2-methyl-5-[(4-methyl-1,3-thiazol-5-yl)methoxy]-1-benzofuran-3-yl}cyclopropane-1-amine; Cpd 028-5-{5-[(2-chloro-6-fluorophenyl)methoxy]-2-methyl-1-benzofuran-3-yl}-3-methyl-1,2,4-oxadiazole; Cpd 029-2-[5-(benzyloxy)-2-methyl-1-benzofuran-3-yl]-6-(2,2,2-trifluoroethyl)pyrazine; Cpd 030-2-[5-(benzyloxy)-2-methyl-1-benzofuran-3-yl]-4-(2,2,2-trifluoroethyl)pyrimidine; Cpd 031-{6-[5-(Benzyloxy)-2-methyl-1-benzofuran-3-yl]pyrazin-2-yl}methanol; Cpd 032-{2-[5-(Benzyloxy)-2-methyl-1-benzofuran-3-yl]pyrimidin-4-yl}methanol; and physiologically acceptable salts thereof.

[0112] The present invention also encompasses pharmaceutical compositions comprising at least one compound of the present invention.The present invention also encompasses a pharmaceutical composition comprising at least one compound of the present invention and at least one acceptable carrier, excipient or diluent for pharmaceutical purposes.

[0113] In some embodiments, the present invention relates to the use of at least one compound of formula (I) or any subgroup thereof for the prevention and / or treatment of pain or epilepsy; preferably pain or epileptic encephalopathy (for the preparation of a composition thereof).

[0114] In some embodiments, the present invention relates to a method for preventing and / or treating metabolic pain, wherein the pain is selected from nociceptive pain, inflammatory pain, and neuropathic pain; preferably postoperative pain.

[0115] A, T, U, W, R 1 、R 2 、R 5 、R 5 ',n,R 6 、R 7 、R 8 All definitions, preferred embodiments and preferred meanings of, including preferred substituents, also apply analogously to the compounds according to the present invention, which are not necessarily limited to use for the treatment of pain or epilepsy. Therefore, this aspect of the invention relates to the compounds of the present invention themselves, compositions comprising the compounds of the present invention, medicaments comprising the compounds of the present invention, and compounds of the present invention for preventing and / or treating TRPM3-mediated conditions such as pain, epilepsy and / or inflammatory hypersensitivity; and / or for combating pain, epilepsy and / or inflammatory hypersensitivity. Preferably, the pain is selected from nociceptive pain, inflammatory pain and neuropathic pain. More preferably, the pain is postoperative pain.

[0116] In some embodiments of the present invention, the compound is selected from the group consisting of the above-mentioned Cpd 001 to Cpd 032 and physiologically acceptable salts thereof.

[0117] Another aspect of the present invention relates to a pharmaceutical composition or medicament comprising a compound according to the invention as described above.

[0118] The compounds of the present invention have been shown to be antagonists of TRPM3, and therefore the present invention provides the compounds themselves for use as medicaments, more particularly for use as medicaments for preventing or treating TRPM3-mediated disorders in a subject using a therapeutically effective amount of a compound of the present invention.

[0119] In some embodiments, the compounds of the present invention are the sole pharmacologically active compound administered for therapy. In another embodiment of the present invention, the compounds of the present invention may be used in combination with other therapeutic agents to treat or prevent TRPM3-mediated disorders. Therefore, the present invention also relates to the use of a composition comprising: - one or more compounds of the formulae and examples herein, and - one or more additional therapeutic or prophylactic agents for the prevention or treatment of TRPM3-mediated disorders as biologically active agents in the form of a combined preparation for simultaneous, separate or sequential use.

[0120] The pharmaceutical composition or combined preparation according to the present invention can contain the compound of the present invention in a wide content range according to the intended use and the expected effect of the preparation. Typically, the content of the compound of the present invention of the combined preparation is in the range of 0.1 to 99.9 weight %, preferably 1 to 99 weight %, more preferably 5 to 95 weight %.

[0121] In view of the fact that, when several active ingredients are used in combination, they do not necessarily produce their combined therapeutic effect simultaneously in the mammal to be treated, the corresponding composition can also be in the form of a medical kit or package containing the two components in separate but adjacent reservoirs or compartments. In the latter case, each active ingredient can therefore be formulated in a manner suitable for a route of administration different from that of the other ingredients, for example, one of the active ingredients can be in the form of an oral or parenteral formulation, while the other active ingredient is in the form of an ampoule or aerosol for intravenous injection.

[0122] Those skilled in the art will also recognize that the compounds of the present invention can exist in many different protonation states, depending, among other things, on the pH of their environment. While the structural formulas provided herein depict compounds in only one of several possible protonation states, it should be understood that these structures are merely illustrative, and the present invention is not limited to any particular protonation state—any and all protonated forms of the compounds are intended to fall within the scope of the present invention.

[0123] As used herein, the term "pharmaceutically acceptable salts" refers to the therapeutically active non-toxic salt forms that the compounds of the formulae herein are able to form. Thus, the compounds of the present invention optionally include salts of the compounds herein, especially those containing, for example, Na+ 、Li + , K + , Ca 2+ and Mg 2+ Pharmaceutically acceptable non-toxic salts of. Such salts may include salts derived from a combination of appropriate cations (such as alkali and alkaline earth metal ions or ammonium and quaternary amino ions) with an acid anion moiety (typically a carboxylic acid). The compounds of the present invention may carry multiple positive or negative charges. The net charge of the compounds of the present invention may be positive or negative. Any relevant counterions are generally determined by the synthesis and / or separation methods used to obtain the compounds. Typical counterions include, but are not limited to, ammonium, sodium, potassium, lithium, halides, acetates, trifluoroacetates, and the like, and mixtures thereof. It should be understood that the identity of any associated counterion is not a key feature of the present invention, and the present invention encompasses compounds associated with any type of counterion. In addition, since compounds can exist in a variety of different forms, the present invention is intended to encompass not only forms of compounds associated with counterions (e.g., dry salts), but also forms not associated with counterions (e.g., aqueous or organic solutions). Metal salts are typically prepared by reacting metal hydroxides with compounds of the present invention. Examples of metal salts prepared in this manner are compounds containing Li + 、Na + and K + Salts of less soluble metal salts can be precipitated from solutions of more soluble salts by adding suitable metal compounds. In addition, salts can be formed by acid addition of certain organic and inorganic acids with basic centers (usually amines) or with acidic groups. Examples of such suitable acids include, for example, inorganic acids (such as hydrohalic acids), such as hydrochloric acid or hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, etc.; or organic acids, such as acetic acid, propionic acid, glycolic acid, 2-hydroxypropionic acid, 2-oxopropionic acid, lactic acid, pyruvic acid, oxalic acid (i.e., oxalic acid), malonic acid, succinic acid (i.e., butanedioic acid), maleic acid, fumaric acid, malic acid, tartaric acid, citric acid, methanesulfonic acid, ethanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, cyclamic acid, salicylic acid (i.e., 2-hydroxybenzoic acid), p-aminosalicylic acid, etc. In addition, this term also includes solvates that the compounds of the formula herein and their salts can form, such as hydrates, alcoholates, etc. Finally, it is understood that the compositions herein comprise the compounds of the present invention in their unionized and zwitterionic forms, as well as in the form of hydrates, in combination with a stoichiometric amount of water.

[0124] Also included within the scope of the present invention are salts of the parent compound with one or more amino acids, particularly salts of naturally occurring amino acids found as components of proteins. Amino acids are typically amino acids that carry a side chain having a basic or acidic group (e.g., lysine, arginine, or glutamic acid) or a neutral group (e.g., glycine, serine, threonine, alanine, isoleucine, or leucine).

[0125] The compounds of the present invention also include physiologically acceptable salts thereof. Examples of physiologically acceptable salts of the compounds of the present invention include salts derived from appropriate bases such as alkali metals (e.g., sodium), alkaline earth metals (e.g., magnesium), ammonium and NX4. + (where X is -C 1-6 -alkyl). Physiologically acceptable salts of hydrogen atoms or amino groups include salts of organic carboxylic acids (such as acetic acid, benzoic acid, lactic acid, fumaric acid, tartaric acid, maleic acid, malonic acid, malic acid, isethionic acid, lactobionic acid and succinic acid); organic sulfonic acids (such as methanesulfonic acid, ethanesulfonic acid, benzenesulfonic acid and p-toluenesulfonic acid); and inorganic acids (such as hydrochloric acid, sulfuric acid, phosphoric acid and aminosulfonic acid). Physiologically acceptable salts of compounds containing hydroxyl groups include salts of the anion of the compound with a suitable cation (such as Na + and NX4 + (wherein X is typically independently selected from -H or -C 1-4 -alkyl)). However, salts of acids or bases that are not physiologically acceptable may also be used, for example, to prepare or purify physiologically acceptable compounds. All salts, whether or not derived from physiologically acceptable acids or bases, are within the scope of the present invention.

[0126] As used herein, unless otherwise indicated, the term "enantiomer" means each individual optically active form of a compound of the invention having an optical purity or enantiomeric excess (determined by standard methods in the art) of at least 80% (i.e., at least 90% of one enantiomer and at most 10% of the other enantiomer), preferably at least 90%, and more preferably at least 98%.

[0127] As used herein, the term "isomer" means all possible isomeric forms that a compound of the formula herein may have, including tautomers and stereochemical forms, but excluding positional isomers. Typically, the structures shown herein illustrate only one tautomer or resonance form of a compound, but corresponding alternative configurations are also envisioned. Unless otherwise indicated, the chemical name of a compound represents a mixture of all possible stereochemical isomeric forms, containing all diastereomers and enantiomers of the basic molecular structure (because the compound of the formula herein can have at least one chiral center), as well as stereochemically pure or enriched compounds. More specifically, a stereocenter can have an R configuration or an S configuration, and multiple bonds can have a cis configuration or a trans configuration.

[0128] A pure isomerically pure form of the compound is defined as an isomer that is substantially free of other enantiomeric or diastereomeric forms of the same basic molecular structure. In particular, the term "stereomerically pure" or "chirally pure" relates to a compound having a stereoisomeric excess of at least about 80% (i.e., at least 90% of one isomer and up to 10% of other possible isomers), preferably at least 90%, more preferably at least 94%, and most preferably at least 97%. The terms "enantiomerically pure" and "diastereomerically pure" should be understood in a similar manner, taking into account the enantiomeric excess, diastereomeric excess, respectively, of a mixture.

[0129] Separation of stereoisomers is accomplished by standard methods known to those skilled in the art. One enantiomer of the compounds of the present invention can be separated, substantially free of its opposite enantiomer, by methods such as forming diastereomers using an optically active resolving agent ("Stereochemistry of Carbon Compounds", (1962) E. L. Eiliel, McGraw Hill; Lochmuller, CH, (1975) J. Chromatogr., 113: (3) 283-302). Separation of isomers in a mixture can be achieved by any suitable method, including: (1) forming ionic diastereomeric salts with chiral compounds and separating by fractional crystallization or other methods, (2) forming diastereomeric compounds with chiral derivatizing agents, separating diastereomers and converting them into pure enantiomers, or (3) enantiomers can be separated directly under chiral conditions. In method (1), diastereomeric salts can be formed by reacting an enantiomerically pure chiral base (such as brucine, quinine, ephedrine, strychnine, a-methyl-b-phenylethylamine (amphetamine), etc.) with an asymmetric compound carrying an acidic functional group (such as carboxylic acid and sulfonic acid). The diastereomeric salts can be induced to separate by fractional crystallization or ion chromatography. In order to separate the optical isomers of amino compounds, the addition of chiral carboxylic or sulfonic acids (such as camphorsulfonic acid, tartaric acid, mandelic acid or lactic acid) can lead to the formation of diastereomeric salts. Alternatively, by method (2), the substrate to be resolved can be reacted with one enantiomer of the chiral compound to form a diastereomeric pair (Eliel, E. and Wilen, S. (1994) Stereochemistry of Organic Compounds, John Wiley & Sons, Inc. (Wiley & Sons, Inc.), p. 322). Diastereomeric compounds can be formed by reacting an asymmetric compound with an enantiomerically pure chiral derivatizing agent (e.g., a menthyl derivative), followed by separation of the diastereomers and hydrolysis to produce the free enantiomerically enriched compound. Methods for determining optical purity involve preparing a chiral ester of the racemic mixture, such as the menthyl ester or Mosher ester, α-methoxy-α-(trifluoromethyl)phenyl acetate (Jacob III. (1982) J. Org. Chem. 47:4165), and analyzing the NMR spectrum for the presence of the two atropisomeric diastereomers.According to the method for separating atropisomers of naphthyl-isoquinolines (Hoye, T., WO 96 / 15111), stable diastereomers can be separated and isolated by normal-phase and reverse-phase chromatography. Under method (3), the racemic mixture of two asymmetric enantiomers is separated by chromatography using a chiral stationary phase. Suitable chiral stationary phases are, for example, polysaccharides, in particular cellulose or amylose derivatives. Commercially available chiral stationary phases based on polysaccharides are CA, OA, OB5, OC5, OD, OF, OG, OJ, and OK, and AD, AS, OP(+) and OT(+). Suitable eluents or mobile phases for use in combination with the polysaccharide chiral stationary phase are hexane modified with an alcohol (e.g., ethanol, isopropanol, etc.). ("Chiral Liquid Chromatography" (1989) edited by W. J. Lough, Chapman and Hall, New York; Okamoto Co., Ltd. (1990) "Optical resolution of dihydropyridine enantiomers by high-performance liquid chromatography using phenylcarbamates of polysaccharides as a chiral stationary phase", Journal of Chromatogr. 513: 375-378).

[0130] The terms cis and trans are used herein according to Chemical Abstracts nomenclature and include reference to the position of substituents on ring moieties. The absolute stereochemical configuration of compounds of the formulae described herein can be readily determined by one skilled in the art using well-known methods such as X-ray diffraction.

[0131] When a compound is crystallized from a solution or slurry, it can crystallize in different spatially arranged lattices (this property is called "polymorphism") to form crystals with different crystalline forms, each of which is called a "polymorph". Thus, as used herein, the term "polymorph" refers to a crystalline form of a compound of formula (I) in which the molecules are located in three-dimensional lattice sites. Different polymorphs of a compound of formula (I) may differ from one another in one or more physical properties, such as solubility and dissolution rate, true specific gravity, crystal form, accumulation pattern, flowability and / or solid state stability, etc.

[0132] The compounds of the present invention and their physiologically acceptable salts (hereinafter collectively referred to as active ingredients) can be administered by any route suitable for the condition to be treated, including oral, rectal, nasal, topical (including ocular, buccal and sublingual), vaginal and parenteral (including subcutaneous, intramuscular, intranasal, intravenous, intraarterial, intradermal, intrathecal and epidural). The preferred route of administration may vary depending on, for example, the condition of the recipient.

[0133] A therapeutically effective amount of a formulation of a compound, in particular for the treatment of TRPM3-mediated disorders in humans and other mammals or animals, is preferably a TRPM3 ion channel inhibiting amount of the compound as defined herein and corresponds to an amount that ensures plasma levels of between 1 μg / ml and 100 mg / ml, optionally 10 mg / ml.

[0134] Suitable dosages of the compounds or compositions of the present invention are used to treat or prevent TRPM3-mediated disorders in a subject. Depending on the pathological condition to be treated and the condition of the patient, the effective amount may be divided into several subunits per day or may be administered at intervals of more than one day.

[0135] The present invention further provides (pharmaceutical) compositions comprising one or more compounds of the present invention, more particularly compounds of all formula (I) and other formulas and embodiments described herein and more specific aspects or embodiments thereof. In addition, the present invention provides compounds or (pharmaceutical) compositions of the present invention, more particularly compounds or (pharmaceutical) compositions of all formula (I) and other formulas and embodiments described herein and more specific aspects or embodiments thereof, for use as a medicament, more particularly for the treatment of pain or epilepsy. TRPM3-mediated conditions are selected from pain, epilepsy and inflammatory hypersensitivity conditions.

[0136] The compounds of the present invention can be formulated with conventional carriers and excipients, which are selected according to conventional practice. Tablets will contain excipients, glidants, fillers, binding agents, etc. Aqueous formulations are prepared in sterile form and, when intended to be delivered by a method other than oral administration, will generally be isotonic. The formulations optionally contain excipients such as those described in "Handbook of Pharmaceutical Excipients" (1986).

[0137] Subsequently, as used herein, the term "pharmaceutically acceptable carrier" means any material or substance with which the active ingredient is formulated to facilitate its application or distribution to the area to be treated, for example by dissolving, dispersing or spreading the composition, and / or facilitating its storage, transport or handling without impairing its effectiveness. A pharmaceutically acceptable carrier can be a solid or a liquid or a gas that has been compressed to form a liquid, i.e., the composition of the present invention can be suitably used as a concentrate, emulsion, solution, granules, powder, spray, aerosol, suspension, ointment, cream, tablet, pill or powder.

[0138] The suitable pharmaceutical carrier for the pharmaceutical composition and its formulation is well known to those skilled in the art, and is not particularly limited to its selection within the present invention. It can also include additives, such as wetting agents, dispersants, adhesives, binders, emulsifiers, surfactants, solvents, coatings, antibacterials and antifungals, isotonic agents, etc., with the condition that it is consistent with pharmaceutical practice, i.e., carrier and additives can not produce permanent damage to mammals. The pharmaceutical composition of the present invention can be prepared in any known manner, such as by uniformly mixing, coating and / or grinding active ingredient with selected carrier material and other additives (such as surfactants) when appropriate in one or more step procedures. It can also be prepared by micronization, such as in order to obtain the pharmaceutical composition in the form of microspheres generally having about 1 to 10 gm diameter, i.e., for the preparation of microcapsules for controlled or sustained release active ingredient.

[0139] Although the compounds of the present invention can be administered alone, it is preferred that the compounds exist as pharmaceutical formulations. The formulations of the present invention for both veterinary and human use comprise at least one active ingredient as described above and therefore one or more pharmaceutically acceptable carriers and optionally other therapeutic ingredients. The carrier is optimally "acceptable" in the sense that it is compatible with the other ingredients of the formulation and harmless to its recipient. The formulations include formulations suitable for oral, rectal, nasal, topical (including buccal and sublingual), vaginal or parenteral (including subcutaneous, intramuscular, intravenous, intradermal, intrathecal and epidural) administration. The formulations can be conveniently presented in unit dosage form and can be prepared by any method well known in the pharmaceutical industry. Such methods include the step of associating the active ingredient with a carrier constituting one or more auxiliary ingredients. Typically, the formulation is prepared by uniformly and tightly associating the active ingredient with a liquid carrier or a finely dispersed solid carrier or both and then shaping the product when necessary.

[0140] Formulations of the present invention suitable for oral administration may be presented as discrete units such as capsules, cachets, or tablets, each containing a predetermined amount of the active ingredient; as a powder or granules; as a solution or suspension in an aqueous or non-aqueous liquid; or as an oil-in-water liquid emulsion or a water-in-oil liquid emulsion. The active ingredient may also be presented as a bolus, electuary, or paste.

[0141] Tablets can be prepared by optionally compressing or molding together with one or more auxiliary ingredients. Compressed tablets can be prepared by compressing an active ingredient in a free-flowing form (such as powder or granular form) optionally mixed with a binding agent, lubricant, inert diluent, preservative, surfactant or dispersant in a suitable machine. Molded tablets can be prepared by molding a mixture of a powdered compound moistened with an inert liquid diluent in a suitable machine. Tablets can be optionally coated or scored and can be formulated to provide slow or controlled release of the active ingredient therein. For infections of the eye or other external tissues (e.g., mouth and skin), the formulation is optionally applied as a topical ointment or cream containing, for example, 0.075 to 20% w / w (including a range between 0.1% and 20% active ingredient in increments of 0.1% w / w, such as 0.6% w / w, 0.7% w / w, etc.), preferably 0.2 to 15% w / w, and most preferably 0.5 to 10% w / w of the active ingredient. When formulated as an ointment, the active ingredient can be used with a paraffin or water-miscible ointment base. Alternatively, the active ingredient can be formulated into a cream with an oil-in-water cream base. If desired, the aqueous phase of the cream base can include, for example, at least 30% w / w of a polyol, i.e., an alcohol having two or more hydroxyl groups, such as propylene glycol, 1,3-diol, mannitol, sorbitol, glycerol, and polyethylene glycol (including PEG 400), and mixtures thereof. Topical formulations may desirably include compounds that enhance the absorption or penetration of the active ingredient through the skin or other affected area. Examples of such transdermal penetration enhancers include dimethyl sulfoxide and related analogs.

[0142] The oil phase of the emulsion of the present invention can be made up of known ingredients in a known manner. Although the phase can only contain an emulsifier (also known as an emulsifier), it desirably contains at least one emulsifier and a fat or oil or a mixture of both fat and oil. Optionally, a hydrophilic emulsifier is included together with a lipophilic emulsifier acting as a stabilizer. It is also preferred to include both oil and fat. The emulsifier with or without a stabilizer together constitutes a so-called emulsifying wax, and the wax, together with the oil and fat, constitutes a so-called emulsifying ointment base, which forms the oily dispersed phase of the cream formulation.

[0143] For formulation, select suitable oil or fat based on realizing desired cosmetic properties, because the solubility of active compound in most of oils that may be used for pharmaceutical emulsion formulation is very low.Therefore, emulsifiable paste should optionally be non-greasy, non-dying and washable product with suitable density to avoid leaking from pipe or other container.Can use straight or branched, monobasic or dibasic alkyl ester, as the blend of diisoadipate, isocetyl stearate, coconut fatty acid propylene glycol diester, isopropyl myristate, decyl oleate, isopropyl palmitate, butyl stearate, 2-ethylhexyl palmitate or the branched ester that is called CrodamolCAP, three kinds of latter are preferred esters.According to required character, these can be used alone or be used in combination.Alternatively, can use as high melting point lipid or other mineral oils such as white soft paraffin and / or liquid paraffin.

[0144] Formulations suitable for topical administration to the eye also include eye drops in which the active ingredient is dissolved or suspended in a suitable carrier, especially an aqueous solvent for the active ingredient. The active ingredient is optionally present in such formulations at a concentration of 0.5 to 20%, advantageously 0.5 to 10%, in particular about 1.5% w / w. Formulations suitable for topical administration in the mouth include lozenges comprising the active ingredient in a flavored base (usually sucrose and acacia or tragacanth); pastilles comprising the active ingredient in an inert base (such as gelatin and glycerin or sucrose and acacia); and mouthwashes comprising the active ingredient in a suitable liquid carrier.

[0145] Formulations for rectal administration can be presented as suppositories with a suitable matrix comprising, for example, cocoa butter or salicylates. Formulations suitable for nasal administration, in which the carrier is a solid, include coarse powders having a particle size, for example, in the range of 20 to 500 microns (including particle sizes in the range between 20 and 500 microns in increments of 5 microns, such as 30 microns, 35 microns, etc.), which are administered in a nasal inhalation manner, i.e., rapidly inhaled through the nasal passages from a powder container close to the nose. Suitable formulations for administration as, for example, nasal sprays or nasal drops, in which the carrier is a liquid, include aqueous or oily solutions of the active ingredient. Formulations suitable for aerosol administration can be prepared according to conventional methods and can be delivered together with other therapeutic agents.

[0146] Formulations suitable for vaginal administration may be presented as pessaries, tampons, creams, gels, pastes, foams or spray formulations containing in addition to the active ingredient such carriers as are known in the art to be appropriate.

[0147] Formulations suitable for parenteral administration include aqueous and non-aqueous sterile injection solutions, which may contain antioxidants, buffers, bacteriostats, and solutes that make the formulation isotonic with the blood of the intended recipient; and aqueous and non-aqueous sterile suspensions, which may include suspending agents and thickening agents. The formulations may be present in unit dose or multi-dose containers (e.g., sealed ampoules and vials) and may be stored in freeze-dried (lyophilized) conditions requiring only the addition of a sterile liquid carrier (e.g., water for injection) immediately prior to use. Extemporaneous injection solutions and suspensions may be prepared from sterile powders, granules, and tablets of the types described previously.

[0148] Preferred unit dosage formulations are those containing a daily dose or unit daily sub-dose, as herein above recited, or an appropriate fraction thereof, of the active ingredient.

[0149] It should be understood that in addition to the ingredients particularly mentioned above, the formulations of this invention may include other agents conventional in the art having regard to the type of formulation in question, for example those suitable for oral administration may include flavoring agents.

[0150] The compounds of the present invention can be used to provide controlled-release pharmaceutical formulations ("controlled-release formulations") containing one or more compounds of the present invention as active ingredients, wherein the release of the active ingredient can be controlled and regulated to allow less frequent dosing or to improve the pharmacokinetic or toxicity profile of a given compound of the present invention. Controlled-release formulations suitable for oral administration containing discrete units of one or more compounds of the present invention can be prepared according to conventional methods.

[0151] Another embodiment of the present invention relates to various precursors or "prodrug" forms of the compounds of the present invention. It may be desirable to formulate the compounds of the present invention in the form of chemical species that do not themselves have significant biological activity, but when the compound is delivered to an animal, mammal or human, it will undergo a chemical reaction catalyzed by the normal functions of the body, particularly enzymes present in the stomach or serum, which has the effect of releasing the compound as defined herein. Therefore, the term "prodrug" refers to these species that are converted into the active pharmaceutical ingredient in vivo.

[0152] The prodrugs of the compounds of the present invention may have any form suitable for the compounder, for example, esters are non-limiting common prodrug forms. However, in the present case, the prodrug may necessarily exist in a form in which the covalent bond is cleaved by the action of an enzyme present at the target locus. For example, a C—C covalent bond may be selectively cleaved by one or more enzymes at the target locus, and therefore, prodrugs in forms other than readily hydrolyzable precursors, particularly esters, amides, etc., may be used. The counterparts of the active pharmaceutical ingredient in the prodrug may have different structures, such as amino acid or peptide structures, alkyl chains, sugar moieties, and other structures known in the art.

[0153] For the purposes of the present invention, the term "therapeutically suitable prodrug" is defined herein as "a compound that is modified in such a way that it is converted in vivo to its...

Claims

1. A compound of formula (I), its stereoisomeric form, physiologically acceptable salt, solvate and / or polymorph in R 1 represents -F, -Cl, -Br, -I, -CN, -R W , -OR W , -OC(=O)R W , -NR W R X , -NR W C(=O)R X , -SR W 、 -S(=O)R W 、 -S(=O)2R W 、 -C(=O)R W 、 -C(=O)OR W or -C(=O)NR W R X ; A means 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated; unsubstituted, monosubstituted or polysubstituted; 6-14 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated; or 5-14 membered heteroaryl; which is in each case unsubstituted, replaced by R 2 mono- or poly-substituted; Each R 2 independently selected from -F, -Cl, -Br, -I, -CN, -NO, -NO2, =O, =S, -SF5, -C(=O)-OH, -S(=O)2-OH, -R Y4 、-OR Y5 、-OC(=O)R Y5 、-NR Y5 R Z 、-NR Y5 C(=O)R Z 、- SR Y5 、 -S(=O)R Y5 、 -S(=O)₂R Y5 、 -NR Y5 S(=O)₂R Z 、 -C(=O)R Y5 、 -C(=O)OR Y5 or - C(=O)NR Y5 R Z ; T stands for -O-, and U stands for -(CR 5 R 5 ') n -; or T means -(CR 5 R 5 ') n -, and U represents -O-; n is an integer selected from 1, 2, 3, 4 or 5; R 5 and R 5 'Independently represent -R Y4 ; R 6 , R 7 and R 8 Independently represent -F, -Cl, -Br, -I, -CN, -NO2, -SF5, -R W 、-OR W 、-OC(=O)R W 、-NR W R X 、-NR W C(=O)R X 、-SR W 、-S(=O)R W 、-S(=O)2R W 、-C(=O)R W 、-C(=O)OR W or -C(=O)NR W R X ; W stands for 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated; unsubstituted, monosubstituted or polysubstituted; 6-14 membered aryl which is unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 5-14 membered heteroaryl which is unsubstituted, monosubstituted or polysubstituted; or -C1-C6-alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl; which are in each case unsubstituted, monosubstituted or polysubstituted; in R W and R X Independently of each other, in each case independently -H； - C1-C6-alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; - C1-C6-heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; or 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered heterocycloalkyl is optionally linked via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; R Y4 , R Y5 and R Z Independently of each other, in each case independently -H； - C1-C6-alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; - C1-C6-heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered heterocycloalkyl is optionally linked via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 6-14 membered aryl, which is unsubstituted, monosubstituted or polysubstituted; wherein the 6-14 membered aryl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; or 5-14 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted; wherein the 5-14 membered heteroaryl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; and wherein "mono- or polysubstituted" in each case independently means substitution by one or more substituents independently selected from the group consisting of: -F, -Cl, -Br, -I, -CN, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C 1-6 -alkylene-CF2H, -C 1-6 -alkylene-CFH2, -C 1-6 -Alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-C 1-6 -alkyl, -C(=O)OH, -C 1-6 -alkylene-C(=O)-OH, -C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)-NH2, -C 1-6 -alkylene-C(=O)-NH2, -C(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -C(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -C(=O)-NH(OH), -C 1-6 -alkylene-C(=O)-NH(OH), -OH, -C 1-6 -alkylene-OH, =O, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -C 1-6 -Alkylene-OC 1-6 -alkyl, -OC 1-6 -Alkylene-OC 1-6 -alkyl, -OC 1-6 -Alkylene-NH2, -OC 1-6 -Alkylene-NH-C 1-6 -alkyl, -OC 1-6 -alkylene-N(C 1-6 -alkyl)2, -OC(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-OC(=O)-C 1-6 -alkyl, -OC(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-OC(=O)-OC 1-6 -alkyl, -OC(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-OC(=O)-NH(C 1-6 -alkyl), -OC(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-OC(=O)-N(C 1-6 -alkyl)2, -OS(=O)2-NH2, -C 1-6 -alkylene-OS(=O)2-NH2, -OS(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-OS(=O)2-NH(C 1-6 -alkyl), -OS(=O)2-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-OS(=O)2-N(C 1-6 -alkyl)2, -NH2, -NO, -NO2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-NH-C(=O)-C 1-6 -alkyl, -NH-C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-NH-C(=O)-OC 1-6 -alkyl, -NH-C(=O)-NH2, -C 1-6 -alkylene-NH-C(=O)-NH2, -NH-C(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-NH-C(=O)-NH(C 1-6 -alkyl), -NH-C(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-C(=O)-N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-NH2, -N(C 1-6 -alkyl)-C(=O)-NH(C 1-6 -alkyl), -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)-C(=O)-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C(=O)-N(C 1-6 -alkyl)2, -NH-S(=O)2OH, -C 1-6 -alkylene-NH-S(=O)2OH, -NH-S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-OC 1-6 -alkyl, -C 1-6 -Alkylene-NH-S(=O)2-OC 1-6 -alkyl, -NH-S(=O)2-NH2, -C 1-6 -alkylene-NH-S(=O)2-NH2, -NH-S(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-NH-S(=O)2-NH(C 1-6 -alkyl), -NH-S(=O)2N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH-S(=O)2N(C 1-6 -alkyl)2, -N(C 1-6 -alkyl)-S(=O)2-OH, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-OH, -N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-C 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-OC 1-6 -alkyl, -N(C 1-6 -alkyl)-S(=O)2-NH2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-NH2, -N(C 1-6 -alkyl)-S(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)-S(=O)2-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-N(C 1-6 -alkyl)-S(=O)2-N(C 1-6 -alkyl)2, -SH, =S, -SF5, -SCF3, -SCF2H, -SCFH2, -SC 1-6 -alkyl, -C 1-6 -Alkylene-SC 1-6 -alkyl, -S(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-S(=O)-C 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -C 1-6 -alkylene-S(=O)2-C 1-6 -alkyl, -S(=O)2-OH, -C 1-6 -alkylene-S(=O)2-OH, -S(=O)2-OC 1-6 -alkyl, -C 1-6 -Alkylene-S(=O)2-OC 1-6 -alkyl, -S(=O)2-NH2, -C 1-6 -alkylene-S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -C 1-6 -alkylene-S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, -C 1-6 -alkylene-S(=O)2-N(C 1-6 -alkyl)2,3-14-membered cycloalkyl, -C 1-6 -alkylene-(3-14 membered cycloalkyl), 3 to 14 membered heterocycloalkyl, -C 1-6 -alkylene-(3 to 14-membered heterocycloalkyl), -phenyl, -C 1-6 -alkylene-phenyl, 5- to 14-membered heteroaryl, -C 1-6 -alkylene-(5- to 14-membered heteroaryl), -O-(3- to 14-membered cycloalkyl), -O-(3- to 14-membered heterocycloalkyl), -O-phenyl, -O-(5- to 14-membered heteroaryl), -C(=O)-(3- to 14-membered cycloalkyl), -C(=O)-(3- to 14-membered heterocycloalkyl), -C(=O)-phenyl, -C(=O)-(5- to 14-membered heteroaryl), -S(=O)2-(3- to 14-membered cycloalkyl), -S(=O)2-(3- to 14-membered heterocycloalkyl), -S(=O)2-phenyl, or -S(=O)2-(5- to 14-membered heteroaryl); When R 1 is hydrogen, A is not and Wherein the compound is not:

2. The compound according to claim 1, wherein T represents -O-, and U represents -(CR 5 R 5 ') n -.

3. The compound according to any one of claims 1 or 2, wherein n is 1.

4. A compound according to any one of claims 1 to 3, wherein A represents 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, mono- or poly-substituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CN, =O, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -C 1-6 -Alkylene-OC 1-6 -alkyl, -OC 1-6 -alkylene-NH2, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -Alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C(=O)-OC 1-6 -alkyl, -SH, -C 1-6 -alkylene-SH, -SC 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14-membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-OH, -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-C 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)-NH2; 6-14 membered aryl, which is unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CN, =O, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -C 1-6 -Alkylene-OC 1-6 -alkyl, -OC 1-6 -alkylene-NH2, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -Alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C(=O)-OC 1-6 -alkyl, -SH, -C 1-6 -alkylene-SH, -SC 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14-membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-OH, -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-C 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)-NH2; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, mono- or poly-substituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CN, =O, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -C 1-6 -Alkylene-OC 1-6 -alkyl, -OC 1-6 -alkylene-NH2, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -Alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C(=O)-OC 1-6 -alkyl, -SH, -C 1-6 -alkylene-SH, -SC 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14-membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-OH, -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-C 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -C(=O)-NH2; 5-14 membered heteroaryl, which is unsubstituted, monosubstituted or polysubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CN, =O, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OH, -C 1-6 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-6 -alkyl, -C 1-6 -Alkylene-OC 1-6 -alkyl, -OC 1-6 -alkylene-NH2, -NH2, -C 1-6 -alkylene-NH2, -NH(C 1-6 -alkyl), -N(3-14 membered cycloalkyl)(C 1-6 -alkyl), -C 1-6 -alkylene-NH(C 1-6 -alkyl), -N(C 1-6 -alkyl)2, -NH-C 1-6 -alkylene-C(=O)-NH2, -NH-C 1-6 -alkylene-C(=O)-NH(C 1-6 -alkyl), -NH-C 1-6 -alkylene-C(=O)-N(C 1-6 -alkyl)2, -NH-C(=O)-C 1-6 -alkyl, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-OH, -N(C 1-6 -alkyl)-C(=O)-C 1-6 -alkylene-OH, -NH-C(=O)-C 1-6 -Alkylene-OC 1-6 -alkyl, -NH-C(=O)-C 1-6 -alkylene-NH2, -NH-C(=O)-C 1-6 -alkylene-NH(C 1-6 -alkyl), -NH-C(=O)-C 1-6 -alkylene-N(C 1-6 -alkyl)2, -NH-C(=O)-OC 1-6 -alkyl, -SH, -C 1-6 -alkylene-SH, -SC 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-C 1-6 -alkyl, -NH-S(=O)2-(3-14-membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-(3-14 membered cycloalkyl), -NH-S(=O)2-C 1-6 -alkylene-OH, -NH-S(=O)2-OC 1-6 -alkyl, -C(=O)-C 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-C 1-6 -alkyl, -C(=O)-OC 1-6 -alkyl, -C 1-6 -alkylene-C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -Alkylene-CF3, -C(=O)-NH2.

5. A compound according to any one of claims 1 to 4, wherein A represents 3-10 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, mono-, di- or tri-substituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CN, =O, -C 1-5 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OH, -C 1-5 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-5 -alkyl, -NH2, -C 1-5 -alkylene-NH2, -NH(C 1-5 -alkyl), -N(3-8 membered cycloalkyl)(C 1-5 -alkyl), -C 1-5 -alkylene-NH(C 1-5 -alkyl), -N(C 1-5 -alkyl)2, -NH-C 1-5 -alkylene-C(=O)-NH2, 5-NH-C(=O)-C 1-5 -alkyl, -N(C 1-5 -alkyl)-C(=O)-C 1-5 -alkyl, -NH-C(=O)-C 1-5 -alkylene-OH, -NH-C(=O)-C 1-5 -Alkylene-OC 1-5 -alkyl, -NH-C(=O)-C 1-5 -alkylene-NH2, -NH-C(=O)-C 1-5 -alkylene-NH(C 1-5 -alkyl), -NH-C(=O)-C 1-5 -alkylene-N(C 1-5 -alkyl)2, -S(=O)2-C 1-5 -alkyl, -NH-S(=O)2-C 1-5 -alkyl, -NH-S(=O)2-(3-8 membered cycloalkyl), -NH-S(=O)2-C 1-5 -alkylene-(3-8 membered cycloalkyl), -NH-S(=O)2-C 1-5 -alkylene-OH, -NH-S(=O)2-OC 1-5 -alkyl, -C(=O)-C 1-5 -alkyl, -C(=O)-OC 1-5 -alkyl, -C(=O)-NH2; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, mono-, di- or tri-substituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CN, =O, -C 1-5 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OH, -C 1-5 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-5 -alkyl, -NH2, -C 1-5 -alkylene-NH2, -NH(C 1-5 -alkyl), -N(3-8 membered cycloalkyl)(C 1-5 -alkyl), -C 1-5 -alkylene-NH(C 1-5 -alkyl), -N(C 1-5 -alkyl)2, -NH-C 1-5 -alkylene-C(=O)-NH2, 5-NH-C(=O)-C 1-5 -alkyl, -N(C 1-5 -alkyl)-C(=O)-C 1-5 -alkyl, -NH-C(=O)-C 1-5 -alkylene-OH, -NH-C(=O)-C 1-5 -Alkylene-OC 1-5 -alkyl, -NH-C(=O)-C 1-5 -alkylene-NH2, -NH-C(=O)-C 1-5 -alkylene-NH(C 1-5 -alkyl), -NH-C(=O)-C 1-5 -alkylene-N(C 1-5 -alkyl)2, -S(=O)2-C 1-5 -alkyl, -NH-S(=O)2-C 1-5 -alkyl, -NH-S(=O)2-(3-8 membered cycloalkyl), -NH-S(=O)2-C 1-5 -alkylene-(3-8 membered cycloalkyl), -NH-S(=O)2-C 1-5 -alkylene-OH, -NH-S(=O)2-OC 1-5 -alkyl, -C(=O)-C 1-5 -alkyl, -C(=O)-OC 1-5 -alkyl, -C(=O)-NH2; 5-14 membered heteroaryl, which is unsubstituted, monosubstituted, disubstituted or trisubstituted independently of one another by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -CN, =O, -C 1-5 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -OH, -C 1-5 -alkylene-OH, -OCF3, -OCF2H, -OCFH2, -OCF2Cl, -OCFCl2, -OC 1-5 -alkyl, -NH2, -C 1-5 -alkylene-NH2, -NH(C 1-5 -alkyl), -N(3-8 membered cycloalkyl)(C 1-5 -alkyl), -C 1-5 -alkylene-NH(C 1-5 -alkyl), -N(C 1-5 -alkyl)2, -NH-C 1-5 -alkylene-C(=O)-NH2, 5-NH-C(=O)-C 1-5 -alkyl, -N(C 1-5 -alkyl)-C(=O)-C 1-5 -alkyl, -NH-C(=O)-C 1-5 -alkylene-OH, -NH-C(=O)-C 1-5 -Alkylene-OC 1-5 -alkyl, -NH-C(=O)-C 1-5 -alkylene-NH2, -NH-C(=O)-C 1-5 -alkylene-NH(C 1-5 -alkyl), -NH-C(=O)-C 1-5 -alkylene-N(C 1-5 -alkyl)2, -S(=O)2-C 1-5 -alkyl, -NH-S(=O)2-C 1-5 -alkyl, -NH-S(=O)2-(3-8 membered cycloalkyl), -NH-S(=O)2-C 1-5 -alkylene-(3-8 membered cycloalkyl), -NH-S(=O)2-C 1-5 -alkylene-OH, -NH-S(=O)2-OC 1-5 -alkyl, -C(=O)-C 1-5 -alkyl, -C(=O)-OC 1-5 -alkyl, -C(=O)-NH2.

6. A compound according to any one of claims 1 to 5, wherein W represents 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, mono-substituted or poly-substituted independently by substituents selected from the group consisting of -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -Alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -Alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -Alkylene-OC 1-6 -alkyl, -C 1-6 -Alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, 3-14 membered cycloalkyl, 3-14 membered heterocycloalkyl, unsubstituted -phenyl, 5- to 14-membered heteroaryl; 6-14 membered aryl, which is unsubstituted, independently selected from the following mono- or poly-substituted: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -Alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -Alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -Alkylene-OC 1-6 -alkyl, -C 1-6 -Alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, 3-14 membered cycloalkyl, 3-14 membered heterocycloalkyl, unsubstituted -phenyl, 5- to 14-membered heteroaryl; 3-14 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, independently selected from the following mono- or poly-substituted: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -Alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -Alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -Alkylene-OC 1-6 -alkyl, -C 1-6 -Alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, 3-14 membered cycloalkyl, 3-14 membered heterocycloalkyl, unsubstituted -phenyl, 5- to 14-membered heteroaryl; 5-14 membered heteroaryl, which is unsubstituted, independently selected from the following mono- or poly-substituted: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -Alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -Alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -Alkylene-OC 1-6 -alkyl, -C 1-6 -Alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, 3-14 membered cycloalkyl, 3-14 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 14 membered heteroaryl; or -C1-C6-alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl; which are in each case unsubstituted, monosubstituted or polysubstituted independently by substituents selected from the group consisting of: -F, -Cl, -Br, -I, -C 1-6 -alkyl, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C(=O)-C 1-6 -alkyl, -C(=O)OH, -C(=O)-OC 1-6 -alkyl, -C(=O)OC 1-6 -alkylene-CF3, -OH, =O, -OC 1-6 -alkyl, -NH2, -NHC 1-6 -alkyl, -N(C 1-6 -alkyl)2, -C 1-6 -alkylene-NH2, -C 1-6 -Alkylene-NH-C 1-6 -alkyl, -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -C 1-6 -Alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-OH, -C 1-6 -Alkylene-OC 1-6 -alkyl, -C 1-6 -Alkylene-NHC(=O)OC 1-6 -alkyl, -NHC(=O)OC 1-6 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-6 -alkyl, -C(=O)-N(C 1-6 -alkyl)2, -S(=O)2C 1-6 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-6 -alkyl), -S(=O)2-N(C 1-6 -alkyl)2, 3-14 membered cycloalkyl, 3-14 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 14 membered heteroaryl.

7. A compound according to any one of claims 1 to 6, wherein W represents 3-10 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, mono-, di- or tri-substituted independently by substituents selected from: -F, -Cl, -Br, -C 1-5 -alkyl, -CF3, -CF2H, -CFH2, -C(=O)-C 1-5 -alkyl, -C(=O)OH, -C(=O)-OC 1-5 -alkyl, -OH, =O, -OC 1-5 -alkyl, -NH2, -NHC 1-5 -alkyl, -N(C 1-5 -alkyl)2, -C 1-5 -alkylene-NH2, -C 1-5 -alkylene-OH, -C 1-5 -Alkylene-OC 1-5 -alkyl, -C 1-5 -Alkylene-NHC(=O)OC 1-5 -alkyl, -NHC(=O)OC 1-5 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-5 -alkyl, -C(=O)-N(C 1-5 -alkyl)2, -S(=O)2C 1-5 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-5 -alkyl), 3-8 membered cycloalkyl, 3-10 membered heterocycloalkyl, unsubstituted -phenyl, 5- to 10-membered heteroaryl; 6-12 membered aryl groups which are unsubstituted, independently selected from the following mono-, di- or tri-substituted: -F, -Cl, -Br, -C 1-5 -alkyl, -CF3, -CF2H, -CFH2, -C(=O)-C 1-5 -alkyl, -C(=O)OH, -C(=O)-OC 1-5 -alkyl, -OH, =O, -OC 1-5 -alkyl, -NH2, -NHC 1-5 -alkyl, -N(C 1-5 -alkyl)2, -C 1-5 -alkylene-NH2, -C 1-5 -alkylene-OH, -C 1-5 -Alkylene-OC 1-5 -alkyl, -C 1-5 -Alkylene-NHC(=O)OC 1-5 -alkyl, -NHC(=O)OC 1-5 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-5 -alkyl, -C(=O)-N(C 1-5 -alkyl)2, -S(=O)2C 1-5 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-5 -alkyl), 3-8 membered cycloalkyl, 3-10 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 10 membered heteroaryl; 3-10 membered heterocycloalkyl, which is saturated or unsaturated, unsubstituted, independently selected from the following mono-, di- or tri-substituted: -F, -Cl, -Br, -C 1-5 -alkyl, -CF3, -CF2H, -CFH2, -C(=O)-C 1-5 -alkyl, -C(=O)OH, -C(=O)-OC 1-5 -alkyl, -OH, =O, -OC 1-5 -alkyl, -NH2, -NHC 1-5 -alkyl, -N(C 1-5 -alkyl)2, -C 1-5 -alkylene-NH2, -C 1-5 -alkylene-OH, -C 1-5 -Alkylene-OC 1-5 -alkyl, -C 1-5 -Alkylene-NHC(=O)OC 1-5 -alkyl, -NHC(=O)OC 1-5 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-5 -alkyl, -C(=O)-N(C 1-5 -alkyl)2, -S(=O)2C 1-5 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-5 -alkyl), 3-8 membered cycloalkyl, 3-10 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 10 membered heteroaryl; 5-10 membered heteroaryl, which is unsubstituted, independently selected from the following mono-, di- or tri-substituted: -F, -Cl, -Br, -C 1-5 -alkyl, -CF3, -CF2H, -CFH2, -C(=O)-C 1-5 -alkyl, -C(=O)OH, -C(=O)-OC 1-5 -alkyl, -OH, =O, -OC 1-5 -alkyl, -NH2, -NHC 1-5 -alkyl, -N(C 1-5 -alkyl)2, -C 1-5 -alkylene-NH2, -C 1-5 -alkylene-OH, -C 1-5 -Alkylene-OC 1-5 -alkyl, -C 1-5 -Alkylene-NHC(=O)OC 1-5 -alkyl, -NHC(=O)OC 1-5 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-5 -alkyl, -C(=O)-N(C 1-5 -alkyl)2, -S(=O)2C 1-5 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-5 -alkyl), 3-8 membered cycloalkyl, 3-10 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 10 membered heteroaryl; or -C1-C6-alkyl, which is unsubstituted, monosubstituted, disubstituted or trisubstituted by substituents independently selected from the group consisting of: -F, -Cl, -Br, -C 1-5 -alkyl, -CF3, -CF2H, -CFH2, -C(=O)-C 1-5 -alkyl, -C(=O)OH, -C(=O)-OC 1-5 -alkyl, -OH, =O, -OC 1-5 -alkyl, -NH2, -NHC 1-5 -alkyl, -N(C 1-5 -alkyl)2, -C 1-5 -alkylene-NH2, -C 1-5 -alkylene-OH, -C 1-5 -Alkylene-OC 1-5 -alkyl, -C 1-5 -Alkylene-NHC(=O)OC 1-5 -alkyl, -NHC(=O)OC 1-5 -alkyl, -C(=O)NH2, -C(=O)-NH-C 1-5 -alkyl, -C(=O)-N(C 1-5 -alkyl)2, -S(=O)2C 1-5 -alkyl, -S(=O)2-NH2, -S(=O)2-NH(C 1-5 -alkyl), 3-8 membered cycloalkyl, 3-10 membered heterocycloalkyl, unsubstituted -phenyl, 5 to 10 membered heteroaryl.

8. A compound according to any one of claims 1 to 7, wherein R 1 Indicates -H, -F, -Cl, -Br, -I, -CN, -C 1-6 -alkyl, -OC 1-6 -alkyl, -C 1-6 -Alkylene-OC 1-6 -alkyl, -C 1-6 -alkylene-NH(C 1-6 -alkyl), -C 1-6 -alkylene-N(C 1-6 -alkyl)2, -CF3, -CF2H, -CFH2, -CF2Cl, -CFCl2, -C 1-6 -alkylene-CF3, -C 1-6 -alkylene-CF2H, -C 1-6 -alkylene-CFH2, -C 1-6 -Alkylene-NH-C 1-6 -alkylene-CF3, -C 1-6 -alkylene-N(C 1-6 -alkyl)-C 1-6 -alkylene-CF3, -C(=O)C 1-6 -alkyl, -C(=O)OC 1-6 -alkyl, -C(=O)NHC 1-6 -alkyl, -C(=O)NH2, -C(=O)N(C 1-6 -alkyl)2, -S(=O)-C 1-6 -alkyl, -S(=O)2-C 1-6 -alkyl, -OC 1-6 -alkyl, unsubstituted-cyclopropyl, unsubstituted cyclobutyl, unsubstituted cyclopentyl or unsubstituted cyclohexyl.

9. A compound according to any one of claims 1 to 8, wherein R 5 and R 5 'Independently express -H； - C1-C6-alkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; - C1-C6-heteroalkyl, which is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted; 3-14 membered cycloalkyl, which is saturated or non-aromatic unsaturated, unsubstituted, monosubstituted or polysubstituted; wherein the 3-14 membered cycloalkyl is optionally attached via -C1-C6-alkylene- or -C1-C6-heteroalkylene-, which in each case is saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted.

10. A compound according to any one of claims 1 to 9, wherein R 6 , R 7 and R 8 Independently express -H, -F, -Cl, -Br, -I, -OH, -SH, -SF5, -CN, -NO2, -C(=O)OH, -NH2, -C 1-6 -alkyl, -CF3, -CHF2, -CH2F, -OC 1-6 -alkyl, -OCF3, -OCHF2, -OCH2F, -NHC 1-6 -alkyl, which is unsubstituted or substituted by one or more substituents independently selected from the following: -OH, =O, -F, -Cl, -Br, -I, -SH, =S, -CN, -CF3, -CHF2, -CH2F, -OCF3, -OCHF2, -OCH2F, SF5, -NO2, -C(=O)OH, -NH2 and -C(=O)NH2; -N(C 1-6 -alkyl)2, which is unsubstituted or substituted by one or more substituents independently selected from the following: -OH, =O, -F, -Cl, -Br, -I, -SH, =S, -CN, -CF3, -CHF2, -CH2F, -OCF3, -OCHF2, -OCH2F, SF5, -NO2, -C(=O)OH, -NH2 and -C(=O)NH2; -C(=O)OC 1-6 -alkyl, which is unsubstituted or substituted by one or more substituents independently selected from the following: -OH, =O, -F, -Cl, -Br, -I, -SH, =S, -CN, -CF3, -CHF2, -CH2F, -OCF3, -OCHF2, -OCH2F, SF5, -NO2, -C(=O)OH, -NH2 and -C(=O)NH2; -OC(=O)C 1-6 -alkyl, which is unsubstituted or substituted by one or more substituents independently selected from the following: -OH, =O, -F, -Cl, -Br, -I, -SH, =S, -CN, -CF3, -CHF2, -CH2F, -OCF3, -OCHF2, -OCH2F, SF5, -NO2, -C(=O)OH, -NH2 and -C(=O)NH2; or -C 1-6 -heteroalkyl, which is unsubstituted or substituted by one or more substituents independently selected from the following: -OH, =O, -F, -Cl, -Br, -I, -SH, =S, -CN, -CF3, -CHF2, -CH2F, -OCF3, -OCHF2, -OCH2F, SF5, -NO2, -C(=O)OH, -NH2 and -C(=O)NH2.

11. A compound according to any one of claims 1 to 10, selected from the group consisting of Cpd 001-[1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropyl]methanol; Cpd 002-(2-{2-methyl-5-[(4-methyl-1,3-thiazol-5-yl)methoxy]-1-benzofuran-3-yl}-1,3-oxazol-5-yl)methanol; Cpd 003-2-hydroxy-N-[1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropyl]acetamide; Cpd 004-(1-{2-methyl-5-[(4-methyl-1,3-thiazol-5-yl)methoxy]-1-benzofuran-3-yl}cyclopropyl)methanol; Cpd 005-N-[1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropyl]cyclopropanesulfonamide; Cpd 006-N-[1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropyl]methanesulfonamide; Cpd 007-(2-{2-methyl-5-[(4-methyl-1,3-thiazol-5-yl)methoxy]-1-benzofuran-3-yl}-1H-imidazol-4-yl)methanol; Cpd 008-3-methoxy-N-[1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropyl]propanamide; Cpd 009-2-hydroxy-2-methyl-N-[1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropyl]propanamide; Cpd 010-2-methoxy-N-[1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropyl]acetamide; Cpd 011-1-{2-methyl-5-[(4-methyl-1,3-thiazol-5-yl)methoxy]-1-benzofuran-3-yl}cyclopropane-1-carbonitrile; Cpd 012-2-{[1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropyl]amino}acetamide; Cpd 013-1-cyclopropyl-N-[1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropyl]methanesulfonamide; Cpd 014-1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropane-1-amine; Cpd 015-2-{[1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropyl]amino}propanamide; Cpd 016-1-[1-(2-methyl-5-{[2-(trifluoromethyl)pyridin-3-yl]methoxy}-1-benzofuran-3-yl)cyclopropyl]methanamine; Cpd 017-2-hydroxy-N-(1-{2-methyl-5-[(4-methyl-1,3-thiazol-5-yl)methoxy]-1-benzofuran-3-yl}cyclopropyl)acetamide; Cpd 018-3-[({3-[4,4-bis(hydroxymethyl)-4,5-dihydro-1,3-oxazol-2-yl]-2-methyl-1-benzofuran-5-yl}oxy)methyl]pyridin-2-ol; Cpd 019-1-[5-(Benzyloxy)-2-methyl-1-benzofuran-3-yl]cyclopropane-1-carbonitrile; Cpd 020-N-(2-hydroxyethyl)-1-{2-methyl-5-[(4-methyl-1,3-thiazol-5-yl)methoxy]-1-benzofuran-3-yl}cyclopropane-1-carboxamide; Cpd 021-{1-[5-(Benzyloxy)-2-methyl-1-benzofuran-3-yl]cyclopropyl}methanol; Cpd 022-1-{2-methyl-5-[(4-methyl-1,3-thiazol-5-yl)methoxy]-1-benzofuran-3-yl}cyclopropane-1-carboxamide; Cpd 023-5-{5-[(2-chloro-6-fluorophenyl)methoxy]-2-methyl-1-benzofuran-3-yl}-2H-1,2,3,4-tetrazolyl; Cpd 024-1-{2-methyl-5-[(pyridin-2-yl)methoxy]-1-benzofuran-3-yl}cyclopropane-1-amine; Cpd 025-1-[5-(cyclopropylmethoxy)-2-methyl-1-benzofuran-3-yl]cyclopropane-1-amine; Cpd 026-1-{2-methyl-5-[(2-methyl-1,3-thiazol-5-yl)methoxy]-1-benzofuran-3-yl}cyclopropane-1-amine; Cpd 027-1-{2-methyl-5-[(4-methyl-1,3-thiazol-5-yl)methoxy]-1-benzofuran-3-yl}cyclopropane-1-amine; Cpd 028-5-{5-[(2-chloro-6-fluorophenyl)methoxy]-2-methyl-1-benzofuran-3-yl}-3-methyl-1,2,4-oxadiazole; Cpd 029-2-[5-(Benzyloxy)-2-methyl-1-benzofuran-3-yl]-6-(2,2,2-trifluoroethyl)pyrazine; Cpd 030-2-[5-(Benzyloxy)-2-methyl-1-benzofuran-3-yl]-4-(2,2,2-trifluoroethyl)pyrimidine; Cpd 031-{6-[5-(Benzyloxy)-2-methyl-1-benzofuran-3-yl]pyrazin-2-yl}methanol; Cpd 032-{2-[5-(Benzyloxy)-2-methyl-1-benzofuran-3-yl]pyrimidin-4-yl}methanol; and physiologically acceptable salts thereof.

12. A pharmaceutical composition comprising a compound according to any one of claims 1 to 11.

13. A compound according to any one of claims 1 to 11 or a pharmaceutical composition according to claim 12 for use as a medicament.

14. A compound according to any one of claims 1 to 11 or a pharmaceutical composition according to claim 12 for use in the treatment of pain or epilepsy.

15. The compound for use or pharmaceutical composition for use according to claim 14, wherein the pain is selected from nociceptive pain, inflammatory pain and neuropathic pain; preferably postoperative pain.

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