Ultrafiltration concentration device for vaccine stock solution processing
By designing an ultrafiltration concentration device, using the regulation of fluid pressure, centrifugal separation and backflushing technology, the pollution and waste problems in the concentration process in vaccine production are solved, efficient separation and concentration of vaccine stock solution is achieved, and the ecological environment is protected.
Patent Information
- Application Number
- CN202411889289.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-20
- Publication Date
- 2025-08-08
- Estimated Expiration
- 2044-12-20
AI Technical Summary
During the vaccine production process, there are problems of vaccine stock solution pollution, waste and ecological threats during the concentration process, and the existing ultrafiltration concentration process is difficult to effectively solve.
The ultrafiltration concentration device is adopted that includes a concentration barrel, a concentration cover, a feed pipe, a temperature control layer, a concentration motor, a separator, a drain pipe and a backwash assembly. By adjusting the fluid pressure, centrifugal separation and backwashing, the efficient separation and concentration of the vaccine stock solution can be achieved.
It reduces the pollution and waste of vaccine stock solution, reduces the threat to the ecological environment, and improves the concentration efficiency and product quality.
Smart Images
Figure CN119488805B_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of vaccine production, in particular to an ultrafiltration concentration device for treating vaccine stock solution. Background Art
[0002] In the vaccine production workshop, the virus must go through six major steps, including cultivation, inactivation, purification, concentration, filling, and packaging before it can finally be actually used by people.
[0003] The concentration process has always been taken very seriously. During concentration, it is necessary to pay close attention to the degree of concentration and the threatening problems caused by concentration. The usual solution to this problem is the ultrafiltration concentration process. Usually, this process also represents the first step in separating the product from large pieces of debris, while maximizing product output and quality. In this process, if there is a problem of residual deterioration, the vaccine concentrate is likely to be contaminated on a large scale, leading to fatal problems in product production. At the same time, the concentration process may also be accompanied by a lot of waste and harm to the surrounding ecology. These problems need to be urgently resolved. Summary of the Invention
[0004] The object of the present invention is to provide an ultrafiltration and concentration device for treating vaccine stock solution to solve the problems raised in the above-mentioned background technology.
[0005] In order to solve the above technical problems, the present invention provides the following technical solution: an ultrafiltration and concentration device for processing vaccine stock solution.
[0006] The concentrating device comprises a concentrating barrel and a concentrating cover, the concentrating cover and the concentrating barrel are engaged with each other through a thread, a sealing ring is provided on the concentrating cover, a feed port is provided on the concentrating cover, a feed pipe is provided on the feed port, a control valve is provided on the feed pipe, an adjusting component is provided in the feed pipe, a temperature control layer is provided in the concentrating barrel, a temperature control plate is provided in the temperature control layer, the temperature control plate is connected with the temperature control pipe group through a conduit, a concentrating layer is provided in the concentrating barrel, a concentrating motor is provided in the concentrating motor, a separator is provided on the concentrating barrel, a water outlet and a discharge port are provided on the concentrating barrel, a drainage pipe is provided on the water outlet, a discharge pipe is provided on the discharge port, and a backwash component is provided in the discharge pipe. During the concentrating process, the raw materials are first fed into the concentrating barrel and then fed into the The concentration barrel is fully sealed by the concentration cover, and the sealing valve is used to control the entry of the vaccine concentrate. During the delivery process, the adjustment component can fully adjust the fluid pressure in the feed pipe to reduce residue. When the vaccine concentrate enters the concentration layer, the concentration motor will drive the separator to rotate, thereby causing the vaccine concentrate to centrifuge. The heavier cell membranes and impurity proteins will be separated to the farthest position and discharged to the drain outlet. These materials are then sent to the drainage pipe. The concentrated vaccine concentrate will then be sent to the discharge outlet, and then the discharge outlet will be sent to the discharge pipe. During the transportation process, the backwash component will backwash the inner wall of the discharge pipe to avoid blockage in the discharge pipe.
[0007] The adjustment component includes multiple pressure-sensitive rings, each of which is arranged in the feed pipe, and the pressure-sensitive ring is provided with a circulation hole, and a circulation impeller is provided in the circulation hole. The circulation impeller is rotatably connected to the pressure-sensitive ring, and a lifting column is provided in the pressure-sensitive ring. A sliding rod and a lifting spring are provided in the lifting column. The two ends of the lifting spring respectively press against the lifting column and the sliding rod, and the sliding rod is slidably connected to the inner wall of the lifting column. An elastic switch is provided in the lifting column. During the transportation of vaccine concentrate, the vaccine concentrate will flow in the discharge pipe and in the pressure-sensitive ring, and drive the flow impeller to rotate. During the rotation, the flow impeller will drive the sliding rod to move in the lifting column. The lifting spring is responsible for timely resetting the sliding rod in the lifting column and continuously triggering the elastic switch. The flow speed of the vaccine concentrate can be known through the triggering frequency of the elastic switch. By utilizing its perception of the flow speed, the pressure and flow rate in the feed pipe can be fully adjusted.
[0008] A boost ring is provided in the feed pipe, and multiple boost holes and multiple flow holes are respectively provided on both sides of the boost ring. An extrusion ring is rotatably connected in the boost ring, and teeth are provided on the extrusion ring. An extrusion motor is provided on the feed pipe, and the teeth on the extrusion ring are engaged with the output end of the extrusion motor. The extrusion motor is electrically connected to the elastic switch through a wire. An extrusion chute is provided on the extrusion ring. During the transmission of the vaccine concentrate, the extrusion motor will be affected by the elastic switch. The higher the trigger frequency of the elastic switch, the faster the rotation speed of the extrusion motor, and the faster the flow speed of the vaccine concentrate in the feed pipe, thereby avoiding the accumulation of cell membranes and impurity proteins in the feed pipe for a long time during feeding, which will cause pollution to the vaccine concentrate to be concentrated, and the extrusion chute on the extrusion ring will also accelerate the vaccine concentrate.
[0009] The concentration barrel is provided with a heat-insulating cover, which is provided with a connecting groove. A discharge tray and a debris removal tray are provided in the concentration barrel, which are rotatably connected to the discharge tray, and the separator is rotatably connected to the discharge tray. The separator is connected to the feed pipe. A plurality of separation chambers are provided in the separator, which are connected to the discharge tray. A discharge trough is provided on the discharge tray, and a debris removal hole is provided on the separation chamber, which is connected to the debris removal tray. During the concentration process, the separation chamber in the separator can be controlled to perform centrifugal separation. After centrifugation, the vaccine concentrate will be sent to the discharge tray, and the waste liquid after centrifugation will also be sent to the debris removal tray. The debris removal tray will send out the waste liquid after centrifugation, and the waste liquid after centrifugation will be discharged into the drainage pipe.
[0010] A feedback shrapnel net and a feedback switch group are provided in the debris discharge disk. The feedback shrapnel net is rotationally connected to the debris discharge disk. The feedback switch group includes multiple feedback tubes and feedback columns. Each feedback column is slidingly connected to the corresponding feedback tube. A feedback resistor is provided in the feedback tube, and a sliding sleeve is provided on the feedback column. The sliding sleeve is sleeved on the feedback resistor and slidingly connected to the feedback resistor. A sliding spring is provided in the feedback tube, and the two ends of the sliding spring respectively press against the feedback tube and the sliding sleeve. During the discharge process, the waste liquid after centrifugation will flow through the feedback shrapnel net. When the concentration of the vaccine stock solution is high, the sliding sleeve will fully move on the feedback resistor under the action of the feedback shrapnel net. At this time, the current transmitted will be large, and it can be directly discharged at this time. When the concentration of the vaccine stock solution is low, the impact on the feedback shrapnel net is small. At this time, the waste liquid after centrifugation is not completely impure protein, etc., and needs to be recovered secondary. At this time, the waste liquid after centrifugation is sent to the water storage tank and wait for recovery again.
[0011] The discharge tray is connected with the discharge port through a conduit. A collection trough is provided at the bottom of the concentration barrel, which is connected with the drain port. A booster pump is provided at the drain port. An electric discharge valve is provided on the drainage pipe. The electric discharge valve is electrically connected with the feedback resistor through a wire. A recovery pipe is provided on the drainage pipe. The waste liquid after centrifugation will enter the collection trough. The booster pump in the collection trough will start to operate. The booster pump will send the liquid into the near drainage pipe. According to the feedback current change of the feedback resistor, the electric control valve will choose to discharge the waste liquid after centrifugation directly or send it into the water storage tank to reduce waste and reduce the threat to the ecology caused by the leaked vaccine concentrate.
[0012] A storage tank and a water storage tank are provided at one end of the discharge pipe away from the discharge port. The water storage tank is connected to the recovery pipe. An ultrafiltration membrane is provided in the water storage tank. An ultrafiltration pipe network is provided on the upper end of the ultrafiltration membrane. The ultrafiltration pipe network is connected to the recovery pipe. A reflux pipe is provided on the water storage tank, and the reflux pipe is connected to the feed pipe. The concentrated vaccine stock solution will be fed into the storage pipe, and the liquid discharged after concentration will also be fed into the water storage tank. The discharged liquid will be fed into the ultrafiltration pipe network. The ultrafiltration pipe network will flow into the ultrafiltration membrane at high speed, thereby completing the ultrafiltration operation, and the ultrafiltered stock solution will be fed into the feed pipe, waiting for centrifugation again.
[0013] The backwash assembly includes a backwash pipe and a backwash pump. The input end of the backwash pump is connected to the storage tank. The backwash pipe passes through the wall of the discharge pipe and is connected to the backwash pump. A backwash ring is provided on the backwash pipe. The backwash ring is provided with multiple flow holes. The backwash pipe is provided with threads. The backwash ring is engaged with the backwash pipe through the threads. The backwash pipe is provided with multiple backwash holes. The direction of the backwash holes is spiral. During backwashing, the backwash pump will send the vaccine concentrate that has been transferred to the storage tank into the backwash pipe, and then the vaccine concentrate will be discharged to the inner wall of the discharge pipe. When the backwash ring moves on the backwash pipe, it will also rotate on the backwash pipe under the restriction of the threads, and the backwash holes will act on the backwash ring under the action of the spiral.
[0014] A backwash groove is provided on the backwash ring, a backwash support is provided on the backwash ring, a speed-sensitive paddle is provided in the backwash ring, the speed-sensitive paddle is rotatably connected to the backwash ring, a thread is provided on the backwash support, the speed-sensitive paddle is connected to the backwash support through a spring rod, and the spring rod is a telescopic rod with an elastic recovery function. The backwash support is engaged with the backwash ring. During the backwash process, the liquid will be ejected from the backwash hole and hit the backwash groove on the backwash ring, so that the backwash ring can move on the drainage pipe. When the backwash ring moves, the relative speed between the backwash ring and the discharged vaccine concentrate increases, so that the speed-sensitive paddle is completely moved and rests on the spring rod. Under the power transmission of the spring rod, the backwash support is extended out of the backwash ring, thereby removing the silt accumulated in the discharge pipe.
[0015] Compared with the prior art, the beneficial effects achieved by the present invention are: 1. The present invention adopts a structural component with the ability to adjust the transport pressure, which can fully solve the problem of siltation of the unconcentrated vaccine concentrate due to fluid pressure problems during transportation, and reduce the problem of contamination of the vaccine concentrate by deteriorated proteins and siltation.
[0016] 2. The present invention adopts a structure capable of identifying the concentration of the vaccine stock solution, which can fully centrifuge the vaccine stock solution, fully concentrate the vaccine stock solution, and automatically adjust the processing sequence according to the concentration of its waste liquid, thereby solving the problem of vaccine stock solution waste caused by incomplete centrifugal separation and reducing the possibility of leakage problems affecting the ecological environment.
[0017] 3. The present invention adopts a structural component with backwashing function, which can fully backwash the problem of insufficient flow of vaccine concentrate during transportation, reduce the problem of accumulation and residue of vaccine concentrate, and avoid the problem that these impurities will cause pollution and waste of vaccine concentrate. BRIEF DESCRIPTION OF THE DRAWINGS
[0018] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:
[0019] Figure 1 It is a schematic diagram of the three-dimensional structure of the present invention;
[0020] Figure 2 This is a schematic diagram of the internal structure of the concentration barrel of the present invention;
[0021] Figure 3 yes Figure 2 The structural diagram of the partially enlarged A in the middle;
[0022] Figure 4It is a schematic structural diagram of the regulating assembly of the present invention;
[0023] Figure 5 yes Figure 4 The structural diagram of the partial enlargement of B in the middle;
[0024] Figure 6 It is a schematic diagram of the internal structure of the water storage tank of the present invention;
[0025] Figure 7 It is a schematic structural diagram of the backwash assembly of the present invention;
[0026] Figure 8 yes Figure 7 The structural diagram of C is partially enlarged in the middle;
[0027] Figure 9 It is a schematic diagram of the pipeline layout structure of the present invention;
[0028] In the figure: 1. Concentration barrel; 101. Insulation cover; 102. Connecting slot; 103. Discharge tray; 104. Discharge tray; 105. Separation chamber; 106. Feedback spring net; 107. Feedback switch group; 108. Feedback pipe; 109. Feedback column; 110. Feedback resistor; 112. Sliding spring; 111. Sliding sleeve; 113. Collecting trough; 114. Booster pump; 115. Electric discharge valve; 2. Concentration cover; 3. Feeding port; 4. Feeding pipe; 5. Control valve; 6. Adjustment assembly; 601. Pressure-sensitive ring; 602. Circulation impeller; 603. Lifting column; 604. Sliding rod; 605. Lifting spring; 606. 06. Elastic switch; 607. Booster ring; 608. Extrusion ring; 609. Extrusion motor; 7. Temperature control layer; 8. Temperature control pipeline group; 9. Concentration motor; 10. Separator; 11. Water outlet; 12. Discharge port; 13. Drain pipe; 14. Discharge pipe; 15. Backwash assembly; 1501. Backwash pipe; 1502. Backwash pump; 1503. Backwash ring; 1504. Backwash hole; 1505. Backwash support; 1506. Speed-sensing paddle; 1507. Spring rod; 16. Recovery pipeline; 17. Storage tank; 18. Water storage tank; 19. Ultrafiltration membrane; 20. Ultrafiltration pipeline network; 21. Return pipeline. DETAILED DESCRIPTION
[0029] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.
[0030] The concentrating device comprises a concentrating barrel 1 and a concentrating cover 2, the concentrating cover 2 and the concentrating barrel 1 are engaged with each other through threads, a sealing ring is provided on the concentrating cover 2, a feed port 3 is provided on the feed port 3, a feed pipe 4 is provided on the feed pipe 4, a control valve 5 is provided on the feed pipe 4, an adjusting component 6 is provided in the feed pipe 4, a temperature control layer 7 is provided in the concentrating barrel 1, a temperature control plate is provided in the temperature control layer 7, the temperature control plate is connected to the temperature control pipe group 8 through a conduit, a concentrating layer is provided in the concentrating barrel 1, a concentrating motor 9 is provided in the concentrating motor 9, a separator 10 is provided on the concentrating barrel 1, a water outlet 11 and a discharge port 12 are provided on the concentrating barrel 1, a drainage pipe 13 is provided on the water outlet 11, a discharge pipe 14 is provided on the discharge port 12, and a backwash component 15 is provided in the discharge pipe 14. During the concentration process, first, The raw materials are fed into the concentration barrel through the feed pipe and then into the concentration barrel, and are fully sealed by the concentration cover, and the sealing valve is used to control whether the vaccine concentrate is introduced. During the feeding process, the regulating component can fully adjust the fluid pressure in the feed pipe to reduce the residue. When the vaccine concentrate enters the concentration layer, the concentration motor will drive the separator to rotate, thereby causing the vaccine concentrate to centrifuge. The heavier cell membranes and impurity proteins will be separated to the farthest position and discharged to the drain outlet. These materials are then fed into the drainage pipe, and the concentrated vaccine concentrate will be fed into the discharge outlet, and then the discharge outlet will be fed into the discharge pipe. During the transportation process, the backwash component will backwash the inner wall of the discharge pipe to avoid blockage in the discharge pipe.
[0031] The adjustment component 6 includes a plurality of pressure-sensitive rings 601, each of which is arranged in the feed pipe 4, and a flow hole is provided on the pressure-sensitive ring 601, and a flow impeller 602 is provided in the flow hole, and the flow impeller 602 is rotatably connected to the pressure-sensitive ring 601, and a lifting column 603 is provided in the pressure-sensitive ring 601, and a sliding rod 604 and a lifting spring 605 are provided in the lifting column 603, and the two ends of the lifting spring 605 respectively press against the lifting column 603 and the sliding rod 604, and the sliding rod 604 is slidably connected to the inner wall of the lifting column 603, and the lifting column 603 is provided There is an elastic switch 606. During the transportation of vaccine concentrate, the vaccine concentrate will flow in the discharge pipe and in the pressure-sensitive ring, and drive the flow impeller to rotate. During the rotation, the flow impeller will drive the sliding rod to move in the lifting column. The lifting spring is responsible for the timely reset of the sliding rod in the lifting column and continuously triggers the elastic switch. The flow speed of the vaccine concentrate can be known through the triggering frequency of the elastic switch. By utilizing its perception of the flow speed, the pressure and flow rate in the feed pipe can be fully adjusted.
[0032] A boost ring 607 is provided in the feed pipe 4, and multiple boost holes and multiple flow holes are respectively provided on both sides of the boost ring 607. An extrusion ring 608 is rotatably connected in the boost ring 607, and teeth are provided on the extrusion ring 608. An extrusion motor 609 is provided on the feed pipe 4. The teeth on the extrusion ring 608 are engaged with the output end of the extrusion motor 609. The extrusion motor 609 is electrically connected to the elastic switch 606 through a wire. An extrusion chute is provided on the extrusion ring 608. During the transmission of the vaccine concentrate, the extrusion motor will be affected by the elastic switch. The higher the trigger frequency of the elastic switch, the faster the rotation speed of the extrusion motor, and the faster the flow speed of the vaccine concentrate in the feed pipe, thereby avoiding the accumulation of cell membranes and impurity proteins in the feed pipe for a long time during feeding, causing pollution to the vaccine concentrate to be concentrated, and the extrusion chute on the extrusion ring will also accelerate the vaccine concentrate.
[0033] The concentration barrel 1 is provided with a heat-insulating cover 101, and a connecting groove 102 is provided on the heat-insulating cover 101. A discharge tray 103 and a debris removal tray 104 are provided in the concentration barrel 1, and the debris removal tray 104 is rotatably connected to the discharge tray 103. The separator 10 is rotatably connected to the discharge tray 103. The separator 10 is connected with the feed pipe 4. A plurality of separation chambers 105 are provided in the separator 10, and the separation chamber 105 is connected with the discharge tray 103. A discharge trough is provided on the discharge tray 103, and a debris removal hole is provided on the separation chamber 105. The debris removal hole is connected with the debris removal tray 104. During the concentration process, the separation chamber in the separator can be controlled to perform centrifugal separation. After centrifugal separation, the vaccine concentrate will be sent to the discharge tray, and the waste liquid after centrifugation will also be sent to the debris removal tray. The debris removal tray will send out the waste liquid after centrifugation, and the waste liquid after centrifugation will be discharged into the drainage pipe.
[0034] A feedback spring net 106 and a feedback switch group 107 are provided in the debris removal disc 104. The feedback spring net 106 is rotatably connected to the debris removal disc 104. The feedback switch group 107 includes a plurality of feedback tubes 108 and feedback columns 109. Each feedback column 109 is slidably connected to the corresponding feedback tube 108. A feedback resistor 110 is provided in the feedback tube 108. A sliding sleeve 111 is provided on the feedback column 109. The sliding sleeve 111 is sleeved on the feedback resistor 110 and slidably connected to the feedback resistor 110. A sliding spring 112 is provided in the feedback tube 108. The two ends of the sliding spring 112 are respectively connected. Do not press against the feedback tube 108 and the sliding sleeve 111. During the discharge process, the waste liquid after centrifugation will flow through the feedback shrapnel net. When the concentration of the vaccine stock solution is high, the sliding sleeve will fully move on the feedback resistor under the action of the feedback shrapnel net. At this time, the current transmitted will be large. At this time, you can choose to discharge it directly. When the concentration of the vaccine stock solution is low, the impact on the feedback shrapnel net is small. At this time, the waste liquid after centrifugation is not completely impure protein, etc., and needs to be recovered for the second time. At this time, choose to send the waste liquid after centrifugation into the water storage tank and wait for recycling again.
[0035] The discharge tray 103 is connected with the discharge port 12 through a conduit. A collection trough 113 is provided at the bottom of the concentration barrel 1, and the collection trough 113 is connected with the drain port. A booster pump 114 is provided at the drain port. An electric discharge valve 115 is provided on the drainage pipe 13. The electric discharge valve 115 is electrically connected to the feedback resistor 110 through a wire. A recovery pipe 16 is provided on the drainage pipe 13. The waste liquid after centrifugation will enter the collection trough, and the booster pump in the collection trough will start to operate. The booster pump will send the liquid into the near drainage pipe. According to the feedback current change of the feedback resistor, the electric control valve will choose to discharge the waste liquid after centrifugation directly or send it into the water storage tank to reduce waste and reduce the threat of leaked vaccine concentrate to the ecology.
[0036] The discharge pipe 14 is provided with a storage tank 17 and a water storage tank 18 at one end away from the discharge port 12. The water storage tank 18 is connected to the recovery pipe 16. An ultrafiltration membrane 19 is provided in the water storage tank 18. An ultrafiltration pipe network 20 is provided on the upper end of the ultrafiltration membrane 19. The ultrafiltration pipe network 20 is connected to the recovery pipe 16. A reflux pipe 21 is provided on the water storage tank 18, and the reflux pipe 21 is connected to the feed pipe 4. When the concentrated vaccine stock solution will be fed into the storage pipe, the liquid discharged after concentration will also be fed into the water storage tank, and the discharged liquid will be fed into the ultrafiltration pipe network. The ultrafiltration pipe network will flow into the ultrafiltration membrane at high speed, thereby completing the ultrafiltration operation, and the stock solution after ultrafiltration will be fed into the feed pipe, waiting for centrifugation again.
[0037] The backwash assembly 15 includes a backwash pipe 1501 and a backwash pump 1502. The input end of the backwash pump 1502 is connected to the storage tank 17. The backwash pipe 1501 passes through the wall of the discharge pipe 14 and is connected to the backwash pump 1502. A backwash ring 1503 is provided on the backwash pipe 1501. The backwash ring 1503 is provided with a plurality of flow holes. The backwash pipe 1501 is provided with a thread. The backwash ring 1503 is engaged with the backwash pipe 1501 through the thread. There are multiple backwash holes 1504 on it, and the direction of the backwash holes 1504 is spiral. When backwashing is performed, the backwash pump will send the vaccine concentrate that has been transferred to the storage tank into the backwash pipe, and then the vaccine concentrate will be discharged to the inner wall of the discharge pipe. When the backwash ring moves on the backwash pipe, it will also rotate on the backwash pipe under the restriction of the thread, and the backwash hole will act on the backwash ring under the action of the spiral.
[0038] The recoil ring 1503 is provided with a backwash groove, a backwash support 1505 is provided on the recoil ring 1503, a speed-sensitive paddle 1506 is provided inside the recoil ring 1503, the speed-sensitive paddle 1506 is rotatably connected to the recoil ring 1503, the backwash support 1505 is provided with a thread, the speed-sensitive paddle 1506 is connected to the backwash support 1505 via a spring rod 1507, the spring rod 1507 is a telescopic rod with an elastic recovery function, and the backwash support 1505 is engaged with the recoil ring 1503. During the backwash process, liquid will be ejected from the backwash hole and hit the backwash groove on the backwash ring, so that the backwash ring can move on the drainage pipe. When the backwash ring moves, the relative speed between the backwash ring and the discharged vaccine concentrate increases, so that the speed-sensitive paddle is fully moved and rests on the spring rod. Under the power transmission of the spring rod, the backwash support extends out of the backwash ring, thereby removing the silt accumulated in the discharge pipe.
[0039] Working principle of the present invention: Figure 9, where D represents the controller of the water storage tank, which controls the water content and temperature in the water storage tank; E represents the temperature and humidity control of the storage tank; F represents the refrigerant supply in the concentration tank, which needs to control the temperature of the concentration tank during concentration. The temperature of the refrigerant is -5°C; and G represents the temperature of the refrigerant after the work is completed. Its temperature should be 0°C. If there is a change, the speed of the refrigerant supply needs to be adjusted. H represents the supply of the vaccine concentrate. During the concentration process, the raw materials are first fed into the concentration barrel 1 and then fed into the concentration barrel 1 through the feed pipe 4. The vaccine concentrate will be It flows in the discharge pipe 4 and flows in the pressure-sensitive ring 601, thereby sensing the flow rate of the liquid. By sensing the trigger frequency of the elastic switch 606, the extrusion speed of the extrusion motor 609 will also change accordingly, and it is fully sealed by the concentration cover 2, and the sealing valve is used to control whether the vaccine stock solution is passed in. During the feeding process, when the vaccine stock solution enters the concentration layer, the concentration motor 9 will drive the separator 10 to rotate, and the separation chamber in the separator 10 can be controlled to perform centrifugal separation, and the centrifuged vaccine stock solution is fed to the discharge tray 103. At the same time, the temperature control pipe group 8 and the temperature control layer 7 are used to ensure the separation temperature. Subsequently, the waste liquid after centrifugation will also be sent to the impurity removal disk 104, and the impurity removal disk 104 will send out the waste liquid after centrifugation. The waste liquid after centrifugation will be discharged into the drainage pipe 13, and the booster pump 114 in the collection tank 113 will be operated. The booster pump 114 will send the liquid into the near drainage pipe 13. According to the feedback current change of the feedback resistor 110, the electric control valve 115 will select the processing technology, and the discharged liquid will be sent to the ultrafiltration pipe network 20, and the ultrafiltration pipe network 20 will be sent to the ultrafiltration membrane 1 9 flows at high speed to complete the ultrafiltration operation, and the concentrated vaccine concentrate will be sent to the discharge port 12, and then the discharge port 12 will be sent to the discharge pipe 14. During the transportation process, the backwash component 15 will backwash the inner wall of the discharge pipe 14, and the backwash pump 1502 will send the vaccine concentrate that has been transferred to the storage tank 17 into the backwash pipe 1501, and then the vaccine concentrate will be discharged to the inner wall of the discharge pipe 14, and the backwash ring 1503 will move on the backwash pipe and can also rotate to avoid blockage in the discharge pipe 14.
[0040] It should be noted that, in this document, relational terms such as first and second, etc., are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that includes a list of elements includes not only those elements but also other elements not explicitly listed, or elements inherent to such process, method, article, or apparatus.
[0041] Finally, it should be noted that the above descriptions are merely preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art will be able to modify the technical solutions described in the aforementioned embodiments or substitute equivalents for some of the technical features. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention shall be included within the scope of protection of the present invention.
Claims
1. An ultrafiltration and concentration device for treating vaccine stock solution, characterized in that: The concentrating device comprises a concentrating barrel (1) and a concentrating cover (2), wherein the concentrating cover (2) and the concentrating barrel (1) are engaged with each other through a thread, a sealing ring is provided on the concentrating cover (2), a feed port (3) is provided on the feed port (3), a feed pipe (4) is provided on the feed pipe (4), a control valve (5) is provided on the feed pipe (4), an adjusting component (6) is provided in the feed pipe (4), a temperature control layer (7) is provided in the concentrating barrel (1), a temperature control plate is provided in the temperature control layer (7), and the concentrating barrel (1) is provided with a temperature control layer (7). The temperature control plate is connected to the temperature control pipe group (8) through a conduit, a concentration layer is provided in the concentration barrel (1), a concentration motor (9) is provided in the concentration barrel (1), a separator (10) is provided on the concentration motor (9), a water outlet (11) and a discharge port (12) are provided on the concentration barrel (1), a drainage pipe (13) is provided on the water outlet (11), a discharge pipe (14) is provided on the discharge port (12), and a backwash component (15) is provided in the discharge pipe (14); The regulating assembly (6) includes a plurality of pressure-sensitive rings (601), each of the pressure-sensitive rings (601) is arranged in the feed pipe (4), a circulation hole is provided on the pressure-sensitive ring (601), a circulation impeller (602) is provided in the circulation hole, the circulation impeller (602) is rotatably connected to the pressure-sensitive ring (601), a lifting column (603) is provided in the pressure-sensitive ring (601), a sliding rod (604) and a lifting spring (605) are provided in the lifting column (603), two ends of the lifting spring (605) respectively abut against the lifting column (603) and the sliding rod (604), the sliding rod (604) is slidably connected to the inner wall of the lifting column (603), and an elastic switch (606) is provided in the lifting column (603); A boost ring (607) is provided in the feed pipe (4), and a plurality of boost holes and a plurality of flow holes are provided on both sides of the boost ring (607). An extrusion ring (608) is rotatably connected in the boost ring (607), and the extrusion ring (608) is provided with teeth. An extrusion motor (609) is provided on the feed pipe (4), and the teeth on the extrusion ring (608) are engaged with the output end of the extrusion motor (609). The extrusion motor (609) is electrically connected to the elastic switch (606) through a wire. An extrusion chute is provided on the extrusion ring (608).
2. The ultrafiltration concentration device for treating a vaccine stock solution according to claim 1, characterized in that: The concentration barrel (1) is provided with a heat-insulating cover (101), and a connecting groove (102) is provided on the heat-insulating cover (101). A discharge tray (103) and a debris removal tray (104) are provided in the concentration barrel (1), and the debris removal tray (104) is rotatably connected to the discharge tray (103). The separator (10) is rotatably connected to the discharge tray (103). The separator (10) is communicated with the feed pipe (4). A plurality of separation chambers (105) are provided in the separator (10), and the separation chambers (105) are communicated with the discharge tray (103). A discharge trough is provided on the discharge tray (103), and a debris removal hole is provided on the separation chamber (105), and the debris removal hole is communicated with the debris removal tray (104).
3. The ultrafiltration concentration device for treating a vaccine stock solution according to claim 2, characterized in that: A feedback spring net (106) and a feedback switch group (107) are provided in the debris removal disc (104), the feedback spring net (106) is rotatably connected to the debris removal disc (104), the feedback switch group (107) comprises a plurality of feedback tubes (108) and feedback columns (109), each of the feedback columns (109) is slidably connected to the corresponding feedback tube (108), a feedback resistor (110) is provided in the feedback tube (108), a sliding sleeve (111) is provided on the feedback column (109), the sliding sleeve (111) is sleeved on the feedback resistor (110) and is slidably connected to the feedback resistor (110), a sliding spring (112) is provided in the feedback tube (108), and two ends of the sliding spring (112) respectively press against the feedback tube (108) and the sliding sleeve (111).
4. The ultrafiltration concentration device for treating a vaccine stock solution according to claim 3, characterized in that: The discharge tray (103) is connected to the discharge port (12) through a conduit. A collecting trough (113) is provided at the bottom end of the concentration barrel (1). The collecting trough (113) is connected to the drain port. A booster pump (114) is provided at the drain port. An electric discharge valve (115) is provided on the drain pipe (13). The electric discharge valve (115) is electrically connected to the feedback resistor (110) through a wire. A recovery pipe (16) is provided on the drain pipe (13).
5. The ultrafiltration concentration device for treating a vaccine stock solution according to claim 4, characterized in that: A material storage tank (17) and a water storage tank (18) are provided at one end of the discharge pipe (14) away from the discharge port (12); the water storage tank (18) is communicated with the recovery pipe (16); an ultrafiltration membrane (19) is provided in the water storage tank (18); an ultrafiltration pipe network (20) is provided at the upper end of the ultrafiltration membrane (19); the ultrafiltration pipe network (20) is communicated with the recovery pipe (16); a return pipe (21) is provided on the water storage tank (18); and the return pipe (21) is communicated with the feed pipe (4).
6. The ultrafiltration concentration device for treating a vaccine stock solution according to claim 5, characterized in that: The backwash assembly (15) includes a backwash pipe (1501) and a backwash pump (1502), the input end of the backwash pump (1502) is connected to the storage tank (17), the backwash pipe (1501) passes through the wall of the discharge pipe (14) and is connected to the backwash pump (1502), the backwash pipe (1501) is provided with a backwash ring (1503), the backwash ring (1503) is provided with a plurality of flow holes, the backwash pipe (1501) is provided with a thread, the backwash ring (1503) is engaged with the backwash pipe (1501) through the thread, the backwash pipe (1501) is provided with a plurality of backwash holes (1504), and the direction of the backwash holes (1504) is spiral.
7. The ultrafiltration concentration device for treating a vaccine stock solution according to claim 6, characterized in that: The recoil ring (1503) is provided with a backwash groove, the recoil ring (1503) is provided with a backwash support (1505), a speed-sensitive paddle (1506) is provided in the recoil ring (1503), the speed-sensitive paddle (1506) is rotatably connected to the recoil ring (1503), the backwash support (1505) is provided with a thread, the speed-sensitive paddle (1506) is connected to the backwash support (1505) via a spring rod (1507), the spring rod (1507) is a telescopic rod with an elastic recovery function, and the backwash support (1505) is engaged with the recoil ring (1503).
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